3x5 Partners

3×5 Partners is a venture capital firm based in Portland, Oregon, founded in 2011. The firm specializes in investments within the life sciences and resource-driven sectors, focusing on companies that contribute to the sustainable consumption of resources such as energy, food, waste, and water. It aims to improve patient outcomes through innovations in biopharma and medical devices. 3×5 Partners seeks to identify solution leaders in these fields, believing they will emerge as significant and valuable companies in the future. The firm has managed over 20 companies and has deployed approximately $390 million across its funds and special purpose vehicles. Its investment strategy includes targeting discovery tools in healthcare, biotechnology, energy, and climate tech, with a preference for minority stake investments in companies with transaction values ranging from $15 million to $20 million.

Anthony Louis Arnerich

Co-Founder and Managing Partner

14 past transactions

Kaleidoscope

Series A in 2022
Kaleidoscope Group PBC is a Minneapolis-based company that specializes in providing a cloud-based software platform for designing, building, and managing scholarship programs. The platform connects scholarship funders with students, facilitating a streamlined marketplace that matches qualified candidates with tailored scholarship opportunities. By offering a comprehensive scholarship management solution, Kaleidoscope allows various organizations and individuals, including fund leaders, artists, entrepreneurs, and professionals, to effectively administer and host their scholarship initiatives. Founded in 2016 by Gregory Dehn, Kaleidoscope Group aims to create a frictionless experience in scholarship management.

Koya Medical

Series B in 2022
Koya Medical, Inc. is a company based in Oakland, California, founded in 2018. It focuses on developing a connected wearable platform designed to address the significant unmet needs in the treatment of cancer-related chronic lymphedema and venous diseases. The technology aims to provide a drug-free solution for patients suffering from these conditions, enhancing their quality of life through innovative medical devices.

Good Therapeutics

Series B in 2021
Good Therapeutics, Inc. is a biotechnology company based in Seattle, Washington, founded in 2016. The company specializes in the development of biotherapeutics and self-regulating drugs that deliver therapeutic effects precisely when and where needed. Its innovative approach involves creating context-dependent protein drugs that can sense biomarkers and respond accordingly, thus minimizing systemic toxicity while maintaining therapeutic efficacy. Good Therapeutics employs an algorithm designed for allosterically-regulated proteins, which alter their shape upon binding with specific biomarkers or metabolites, activating their therapeutic functions. The company's primary focus is on applications within immuno-oncology, aiming to enhance treatment outcomes while ensuring patient safety.

Claros Technologies

Series A in 2021
Claros Technologies is an advanced materials company that develops safe and sustainable products with zero toxic waste. It strives to lead the industry towards a holistic approach to materials design and innovation. It was founded in 2018 and is based in St Paul, Minnesota.

Fervo Energy

Series B in 2021
Fervo Energy is a next-generation geothermal developer generating clean power in new places. Fervo Energy commercializes proprietary technology to own, develop, and operate geothermal assets as the dispatchable foundation to a 100% clean energy future.

SOURCE

Series C in 2020
Developer of a hydro panel technology designed to provide safe, clean drinking water for industrial, commercial, residential, and community applications. The company's technology utilizes advanced materials science to pull water from even the driest conditions, producing pure water that is mineralized and delivered to various taps, enabling individuals and businesses to get clean water essentially anywhere.

Amplyx Pharmaceuticals

Series C in 2020
Amplyx Pharmaceuticals is a small molecule drug development company focused on creating innovative therapies for life-threatening infections, particularly in patients with compromised immune systems. Founded in 2006 and based in San Diego, California, the company specializes in developing oral and injectable anti-infective drugs, including antifungal agents aimed at treating invasive fungal infections caused by pathogens such as Candida and Aspergillus. Amplyx employs a unique platform approach that enhances the efficacy and reduces the toxicity of existing drugs by combining them with additional small molecules. This strategy addresses critical treatment needs in hospital settings and provides effective therapy options for patients after discharge, particularly those undergoing chemotherapy and other immunosuppressive treatments.

Good Therapeutics

Series A in 2020
Good Therapeutics, Inc. is a biotechnology company based in Seattle, Washington, founded in 2016. The company specializes in the development of biotherapeutics and self-regulating drugs that deliver therapeutic effects precisely when and where needed. Its innovative approach involves creating context-dependent protein drugs that can sense biomarkers and respond accordingly, thus minimizing systemic toxicity while maintaining therapeutic efficacy. Good Therapeutics employs an algorithm designed for allosterically-regulated proteins, which alter their shape upon binding with specific biomarkers or metabolites, activating their therapeutic functions. The company's primary focus is on applications within immuno-oncology, aiming to enhance treatment outcomes while ensuring patient safety.

Adarza BioSystems

Series D in 2020
Adarza BioSystems is an early-stage medical diagnostics company developing a rapid and label-free biological assay platform for measuring clinical and point-of-care (POC) samples. In addition to performing sophisticated clinical tests within minutes, this technology potentially allowing hundreds of tests to be run simultaneously on a single chip. It was founded in 2008 and headquartered in St Louis, Missouri.

Smart Wires

Series E in 2019
Smart Wires Inc. is a company that specializes in manufacturing and distributing modular power flow control products and grid optimization solutions for transmission organizations globally. Founded in 2010 and headquartered in Union City, California, with additional offices in the United Kingdom and Australia, Smart Wires focuses on enhancing the reliability of electricity transmission grids. Its patented technology enables utilities to manage congestion, improve power transfer capacity, and support renewable energy connections. The company’s solutions address short-term grid challenges, facilitate construction and maintenance projects, and aim to minimize environmental and community disruption. By leveraging advanced power electronics hardware and software, Smart Wires works to optimize grid capacity and adapt to the evolving energy landscape.

InterVene

Series B in 2019
InterVene, Inc. is a medical device company based in South San Francisco, California, focused on developing innovative catheter-based therapies for chronic venous insufficiency (CVI) caused by deep vein valve failure. Founded in 2011, InterVene aims to transform the treatment of severe venous disease in the legs by introducing a novel, non-implantable catheter approach that enables physicians to create new vein valves. This technology addresses a significant unmet need for patients suffering from painful venous stasis ulcers and other debilitating symptoms associated with deep vein reflux. By providing an effective therapy for CVI, InterVene seeks to improve the quality of life for millions of Americans affected by this condition.

Good Therapeutics

Series A in 2019
Good Therapeutics, Inc. is a biotechnology company based in Seattle, Washington, founded in 2016. The company specializes in the development of biotherapeutics and self-regulating drugs that deliver therapeutic effects precisely when and where needed. Its innovative approach involves creating context-dependent protein drugs that can sense biomarkers and respond accordingly, thus minimizing systemic toxicity while maintaining therapeutic efficacy. Good Therapeutics employs an algorithm designed for allosterically-regulated proteins, which alter their shape upon binding with specific biomarkers or metabolites, activating their therapeutic functions. The company's primary focus is on applications within immuno-oncology, aiming to enhance treatment outcomes while ensuring patient safety.

Allakos

Series B in 2017
Allakos Inc. is a clinical-stage biopharmaceutical company based in Redwood City, California, founded in 2012. The company specializes in developing antibody-based therapeutics aimed at treating various diseases linked to dysregulation of the T-helper type 2 immune response, including allergic diseases, inflammation, and conditions characterized by excessive inflammatory cell production. Its lead therapeutic candidate, antolimab (AK002), targets conditions such as eosinophilic gastritis, eosinophilic gastroenteritis, chronic urticaria, indolent systemic mastocytosis, and severe allergic conjunctivitis. Additionally, Allakos is advancing another program, AK006, which targets the Siglec-6 receptor on mast cells to modulate their activity and reduce excessive activation. Through these initiatives, Allakos aims to address significant unmet medical needs in immunological health.

Fishpeople

Series B in 2017
Fishpeople Seafood is a food production company that specializes in providing grocery retail, and sustainable seafood. The company is a dynamic organization experiencing rapid growth and is disrupting the seafood industry status quo by introducing innovative and sustainable seafood products. Fishpeople Seafood was founded in 2012 and is headquartered in Portland, Oregon.
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