Fifty Years

Fifty Years Industries, LLC is a venture capital firm founded in 2016 and based in San Francisco, California. The firm focuses on seed and early-stage investments in a variety of sectors, including synthetic biology, food technology, education, health, civic, community, energy, hardware, software, and robotics, without restricting itself to specific industries. Fifty Years aims to support founders who leverage technology to address significant global challenges, aligning its investments with the Sustainable Development Goals. The firm typically commits to investments for a duration of five years or more, primarily targeting companies in North America and Europe.

Seth Bannon

Founding Partner

Ela Madej

Co-Founder and Partner

David Phoenix

Partner

Alex Teng

Partner

131 past transactions

MultiOmic Health

Seed Round in 2023
Operator of an artificial intelligence-driven drug discovery (AIDD) based precision medicine company intended to address metabolic syndrome-related diseases. The company's platform applies systems biology to discover therapeutics and diagnostics for treating metabolic syndrome patients, it combines integrated multi-omics analysis and computational systems biology modeling with targeted wet laboratory experiments to originate novel precision therapeutic concepts that commercialize via partnerships with established biopharma companies, enabling diagnostic companies to get access to new therapeutic and diagnostic research and development programs for subsequent co-developmentmore

Noya

Series A in 2023
Noya captures CO2 from the sky and re-sells it for 2x cheaper than existing options. We do this by retrofitting existing industrial equipment like cooling towers and converting them into CO2 capture machines.

Persephone Biosciences

Seed Round in 2022
Persephone Biome, Inc. is a San Diego-based company focused on researching and developing products and therapies that modify gut microbial metabolism, particularly in relation to cancer treatment. Established in 2017, the company is creating innovative solutions aimed at enhancing the efficacy of oncology drugs by retuning the gut microbiome. This includes the development of a pill containing beneficial gut bacteria. In addition to its therapeutics, Persephone Biome aims to offer nutritional products that support the human gut microbiome, producing functional foods and beverages that cater to the growing consumer demand for health-oriented products. The company has plans to enter clinical trials to further advance its initiatives in the field of microbiome-directed therapies.

Manifold Bio

Series A in 2022
Manifold Biotechnologies, Inc. is a biotechnology company that specializes in developing platforms for the pharmacological measurement of various therapeutic protein variants. By integrating DNA technologies with machine learning, the company aims to create protein drugs that address challenging diseases. Manifold Bio's innovative approach includes a protein barcoding platform designed to enable multiplexed quantitation of protein therapeutics, thereby generating extensive data that enhances the drug development process. Founded in 2019 and located in Allston, Massachusetts, the company is focused on advancing measurement-driven design in the field of protein therapeutics.

Octant Bio

Series B in 2022
Octant Bio is focused on advancing health and treating complex diseases through innovative synthetic technology. The company utilizes a combination of synthetic biology, genome engineering, next-generation sequencing, and computational methods to assess the activity of numerous receptor pathways within human cells. This approach allows for the development of multi-targeted small molecule drug leads by leveraging machine learning to engineer compounds that interact with multiple receptors. By generating extensive multi-receptor pathway data, Octant Bio aims to enhance rational drug design and uncover new therapeutic possibilities. Founded in 2017 and based in Los Angeles, California, Octant Bio is dedicated to transforming the landscape of drug discovery and development.

Octant Bio

Series B in 2022
Octant Bio is focused on advancing health and treating complex diseases through innovative synthetic technology. The company utilizes a combination of synthetic biology, genome engineering, next-generation sequencing, and computational methods to assess the activity of numerous receptor pathways within human cells. This approach allows for the development of multi-targeted small molecule drug leads by leveraging machine learning to engineer compounds that interact with multiple receptors. By generating extensive multi-receptor pathway data, Octant Bio aims to enhance rational drug design and uncover new therapeutic possibilities. Founded in 2017 and based in Los Angeles, California, Octant Bio is dedicated to transforming the landscape of drug discovery and development.

Ansa Biotechnologies

Series A in 2022
Ansa Biotechnologies, Inc. is a biotechnology company based in Berkeley, California, focused on developing innovative DNA synthesis technology utilizing enzymes. Established in 2018, the company aims to improve upon traditional chemical methods of DNA synthesis that have remained largely unchanged for decades. Ansa's enzymatic approach offers significant advantages, including increased speed, accuracy, and cleanliness in the production of DNA fragments such as oligonucleotides. This technology enhances the capabilities of biological research, therapeutics, diagnostics, and biomanufacturing by enabling the synthesis of gene-length oligonucleotides. Through its advancements, Ansa Biotechnologies seeks to facilitate innovation in the fields of biological research and engineering, ultimately providing valuable services to medical researchers and contributing to the broader biotechnology landscape.

BillionToOne

Series C in 2022
BillionToOne Inc. develops a genetic testing platform that detects and measures disease at the molecular level. It offers UNITY, a noninvasive prenatal screening that tests fetal cell-free DNA for cystic fibrosis and spinal muscular atrophy through a single sample of the mother's blood. The company serves doctors and expecting mothers. BillionToOne Inc. was incorporated in 2016 and is based in Menlo Park, California.

Antora Energy

Series A in 2022
Developer of thermal batteries designed to support the widespread integration of renewable resources on the electricity grid. The company's batteries use solar panels to efficiently convert heat energy to electric energy and also electrify heavy industry with thermal energy storage for zero-carbon heat and power, enabling users to ensure convenient, sustainable and reliable electricity on a global scale while reducing carbon emissions.

MultiOmic Health

Seed Round in 2022
Operator of an artificial intelligence-driven drug discovery (AIDD) based precision medicine company intended to address metabolic syndrome-related diseases. The company's platform applies systems biology to discover therapeutics and diagnostics for treating metabolic syndrome patients, it combines integrated multi-omics analysis and computational systems biology modeling with targeted wet laboratory experiments to originate novel precision therapeutic concepts that commercialize via partnerships with established biopharma companies, enabling diagnostic companies to get access to new therapeutic and diagnostic research and development programs for subsequent co-developmentmore

Athelas

Venture Round in 2022
Athelas, Inc. develops and manufactures an innovative in-home blood diagnostic device designed to monitor the immune system using just a drop of blood. Founded in 2016 and based in Mountain View, California, the company's portable optical unit analyzes blood cells and generates diagnostic reports. This technology assists healthcare providers in early identification of conditions such as leukemia, infections, and inflammatory diseases, allowing patients to monitor their immunity levels conveniently from home. Athelas operates as a subsidiary of MerLion Pharmaceuticals Pte. Ltd.

64x Bio

Series A in 2022
64x Bio is a biotechnology company based in San Francisco, California, founded in 2017 by Alexis Rovner, George Church, Jeffrey Way, and Pamela Silver. The company specializes in designing microorganisms with enhanced properties to facilitate advanced applications in biomanufacturing, bioremediation, and health. By creating cells tailored for specific purposes, 64x Bio aims to enable innovative solutions that were previously unattainable in these fields.

InVivo AI

Seed Round in 2021
InVivo AI is a Montreal-based company founded in 2017 that specializes in using artificial intelligence to enhance pharmaceutical research and development. The company primarily focuses on preclinical toxicology, aiming to improve the efficiency and effectiveness of drug development processes. By leveraging advanced AI technologies, InVivo AI seeks to transform traditional methodologies in the pharmaceutical industry, ultimately contributing to faster and more reliable outcomes in drug safety assessments.

Nabla Bio

Seed Round in 2021
Nabla is an autoreverse platform that enables the rapid discovery of previously unattainable protein variants with supernatural qualities.Nabla Bio makes new medicines and improve nutrition by engineering novel proteins.

Planet A Foods

Seed Round in 2021
QOA manufactures chocolate that is cocoa-free. The company offers chocolate production practices that are made using traditional and precise fermentation.The company was founded in 2021 and is headquartered in Munich, Bavaria.

Superdao

Pre Seed Round in 2021
Developer of a decentralized autonomous organization management platform designed to start and operate decentralized independent organizations. The company's platform uses a hybrid governance system for incentivized collaborative management of disruptive, economically viable decentralized application ventures, and in one click, add and customize intelligent contracts, use a built-in member directory, treasury dashboard, contributor management, newsfeed to do even more with third-party apps, enabling businesses to improve decision-making and governance structure for the decentralized autonomous organizations.

Worldcoin

Venture Round in 2021
Worldcoin is a global digital currency initiative aimed at distributing a free share of its currency to every individual on Earth. The platform focuses on enhancing privacy and transparency through a permissionless blockchain. Worldcoin employs an iris-scanning device that creates a unique digital identity known as World ID. This system not only facilitates the issuance of its digital currency but also securely stores biometric information, which helps prevent fraudulent account creation by discouraging spammers from registering multiple times. Through these innovations, Worldcoin seeks to promote equitable access to digital currency while maintaining user privacy.

Journey Clinical

Seed Round in 2021
Journey Clinical is a platform that provides services to member psychotherapy practices that are independently owned and operated, and in no way owns, directs, or controls the mental healthcare clinicians providing care.

Solugen

Series C in 2021
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Solugen

Series C in 2021
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Pnoe

Funding Round in 2021
PNOE focuses on democratizing cardio-metabolic analysis, providing comprehensive health assessments through its innovative device that delivers clinically accurate measurements of metabolic, cardiac, and pulmonary health. In just ten minutes, this analysis reveals critical insights necessary for creating tailored nutrition and workout plans. PNOE's technology is the first of its kind to be scientifically validated for mass market use, positioning it as a leader in the field of metabolic testing. The company is supported by experts in metabolic analysis and cardiovascular health, and its dedicated engineering team is committed to making cardio-metabolic analysis accessible to a broader audience.

Nabla Bio

Pre Seed Round in 2021
Nabla is an autoreverse platform that enables the rapid discovery of previously unattainable protein variants with supernatural qualities.Nabla Bio makes new medicines and improve nutrition by engineering novel proteins.

unspun

Convertible Note in 2021
Unspun, Inc. is a technology-driven company based in San Francisco, California, specializing in the production of customized jeans using advanced body scanning technology and fit algorithms. Founded in 2015, Unspun aims to revolutionize the apparel industry by reducing global carbon emissions through automated and localized manufacturing processes. The company offers a B2B software platform that enables digital customization for various large apparel brands. Recognized for its innovation, Unspun's technology was featured in TIME's list of Best Inventions of 2019. The company is supported by several notable investors and is actively working on the future of additive and automated apparel production, positioning itself as a leader in the quest for sustainable fashion.

Talus Bio

Pre Seed Round in 2021
Talus Bio is a biotechnology startup specializing in drug discovery, particularly in the field of oncology. The company has developed a data-enabled platform that integrates cell processing with high-sensitivity quantitative proteomics and machine learning analytics. This innovative approach allows for the study of gene regulatory proteins within living cells, facilitating targeted small molecule drug development. By focusing on the mechanisms of gene regulation, Talus Bio aims to enhance drug development processes for clients in the healthcare sector, ultimately advancing therapies for cancer treatment.

Nobell Foods

Series B in 2021
Nobell Foods is a biotech company based in San Francisco, California, that specializes in developing and producing animal-based food substitutes using plant materials. Founded in 2016, the company aims to transform plants into bioreactors to generate protein, unlocking their potential to create innovative food alternatives. By focusing on plant-based solutions, Nobell Foods seeks to provide sustainable options that can replace traditional animal products, contributing to a more environmentally friendly food system.

Atom Computing

Series A in 2021
Atom Computing Inc. is a company based in Berkeley, California, that focuses on manufacturing scalable quantum computers utilizing individual atoms. Founded in 2018, the company harnesses the quantum mechanical properties of atoms to process information and address complex problems that traditional computers cannot solve. Atom Computing's technology allows for the optical control, scaling, and stabilization of these atoms, facilitating efficient quantum calculations in various fields, including drug design, computational chemistry, and general computing. Through its innovative approach, Atom Computing aims to advance the development of quantum technology and expand its applications across multiple industries.

Varda

Series A in 2021
Varda Space Industries, Inc. is a space manufacturing startup founded in 2020 and based in San Francisco, California. The company focuses on creating products in space that can be utilized for terrestrial applications, leveraging the advantages of low gravity. Varda aims to establish an infrastructure that facilitates the harvesting of materials from space, particularly through asteroid mining, to produce new products. The founders of the company are Delian Asparouhov and Trae Stephens.

Meati

Series B in 2021
Meati, also known as Emergy Foods, is a consumer goods company based in Boulder, Colorado, founded in 2016. The company specializes in producing whole muscle, nutritious plant-based meats designed to promote healthier lifestyles and environmental sustainability. By utilizing proprietary, clean technologies, Meati offers nutrient-dense meat alternatives that aim to appeal to a wide audience, ensuring that consumers can enjoy meals that are both good for their health and the planet.

Mindset Health

Seed Round in 2021
Mindset Health Pty Ltd is a digital therapeutics company based in Melbourne, Australia, founded in 2017. It specializes in providing an application that utilizes hypnotherapy to address various mental health issues and chronic conditions. The platform focuses on managing irritable bowel syndrome (IBS) without requiring dietary changes, while also offering solutions for improving sleep, reducing anxiety and stress, and enhancing cognitive behavioral therapy. Mindset Health aims to deliver a rapid, cost-effective, non-addictive, and safe alternative for individuals seeking treatment for chronic pain, anxiety, and depression, making mental health support more accessible to those with a smartphone.

Yuri

Seed Round in 2021
Developer of end-to-end space mission platform intended for microgravity research and experiments. The company offers services including mission definition, hardware selection and development, launch and return, enabling researchers to avail a quick and affordable combination of experiment hardware, facilities and microgravity platform.

Faction

Seed Round in 2021
Faction specializes in the development of driverless electric vehicles that combine the speed and performance of cars with the affordability of motorcycles. The company focuses on micro-delivery and ride-on-demand services, utilizing a model that integrates remote human supervision alongside autonomous technology. This approach allows Faction to bypass the limitations of fully autonomous systems, enabling quicker deployment of its services. The vehicles are designed with networked data capabilities, over-the-air software updates, and safety-critical autonomy features, ensuring a cost-effective and reliable driverless solution for clients. After completing its first prototypes, Faction is set to commence trials to further refine its offerings in the transportation sector.

Gridware

Seed Round in 2021
Gridware provides a grid monitoring system of sensors and software for the power distribution grid. The system centers around a low-cost hardware platform that is easily and permanently deployed to power poles. The platform detects and predicts faults that ignite wildfires, expedites repairs during a power outage, and helps utilities demonstrate risk reduction to regulators through comprehensive asset health profiles.

Multiply Labs

Series A in 2021
Multiply Labs specializes in the manufacturing of personalized pharmaceutical capsules tailored to the specific needs of individual patients. By integrating pharmaceutical science with advanced robotics technology, the company has developed a unique robotic manufacturing facility that allows for the production of these capsules efficiently and cost-effectively. Multiply Labs is notable for being the first company to successfully introduce 3D printed capsules to the market, enabling the pharmaceutical industry to deliver medications that align with the unique metabolic requirements of patients.

Substack

Series B in 2021
Substack Inc. is an online platform that facilitates the creation and publication of both paid and free subscription newsletters for writers. Founded in 2017 and based in San Francisco, the company provides tools that enable writers to simultaneously publish content to an email list and a website while managing subscriber payments. Substack's all-in-one solution is designed to simplify the process of monetizing writing, offering user-friendly editing software, customizable templates, and features that help stories reach broader audiences beyond subscription paywalls. This approach allows writers to connect directly with their readers and generate revenue through their newsletters.

Substack

Series B in 2021
Substack Inc. is an online platform that facilitates the creation and publication of both paid and free subscription newsletters for writers. Founded in 2017 and based in San Francisco, the company provides tools that enable writers to simultaneously publish content to an email list and a website while managing subscriber payments. Substack's all-in-one solution is designed to simplify the process of monetizing writing, offering user-friendly editing software, customizable templates, and features that help stories reach broader audiences beyond subscription paywalls. This approach allows writers to connect directly with their readers and generate revenue through their newsletters.

Faction

Seed Round in 2021
Faction specializes in the development of driverless electric vehicles that combine the speed and performance of cars with the affordability of motorcycles. The company focuses on micro-delivery and ride-on-demand services, utilizing a model that integrates remote human supervision alongside autonomous technology. This approach allows Faction to bypass the limitations of fully autonomous systems, enabling quicker deployment of its services. The vehicles are designed with networked data capabilities, over-the-air software updates, and safety-critical autonomy features, ensuring a cost-effective and reliable driverless solution for clients. After completing its first prototypes, Faction is set to commence trials to further refine its offerings in the transportation sector.

Brave Care

Series A in 2021
Brave Care, Inc. is a healthcare provider specializing in urgent pediatric services. Founded in 2017 and based in Portland, Oregon, the company operates clinics that address a variety of childhood illnesses and injuries. Services offered include treatment for allergies, asthma, coughs, ear pain, eye problems, fever, and urinary tract infections. Brave Care also provides care for minor fractures, strains, sprains, and head trauma, along with pediatric-specific laboratory services and on-site x-ray capabilities. The clinics are equipped to perform procedures such as stitches and tissue glue application for wound closure, as well as mild sedation for uncomfortable treatments.

Noya

Seed Round in 2021
Noya captures CO2 from the sky and re-sells it for 2x cheaper than existing options. We do this by retrofitting existing industrial equipment like cooling towers and converting them into CO2 capture machines.

ReturnSafe

Pre Seed Round in 2020
ReturnSafe Inc. is a BioSecurity company based in Austin, Texas, established in 2020. It specializes in providing solutions aimed at enhancing workplace safety by offering services such as screening, contact tracing, testing management, and vaccine status management. ReturnSafe's offerings include daily symptom screening, contact tracing methods, and vaccine management integrations. The company caters to various sectors, including general business, higher education, long-term care, manufacturing, and travel and hospitality. Founded by Tarun Nimmagadda and Jason Story, ReturnSafe aims to help organizations prevent viral outbreaks, particularly in the context of Covid-19, thereby ensuring a safer environment for employees and visitors.

Oolu

Series B in 2020
Oolu Inc. is a solar energy company based in Dakar, Senegal, with an additional office in San Francisco, California. It specializes in providing solar home systems, technical support, and maintenance services to households in West Africa, particularly targeting off-grid communities in rural areas. Oolu's offerings include installations of solar systems that feature adjustable lights and USB charging capabilities, powered by rechargeable batteries. The company employs a monthly payment model, which makes energy access more affordable for customers while also ensuring ongoing maintenance and support. By fostering trust within local communities, Oolu aims to enhance the quality of life for its clients by providing them with reliable and sustainable energy solutions.

Varda

Seed Round in 2020
Varda Space Industries, Inc. is a space manufacturing startup founded in 2020 and based in San Francisco, California. The company focuses on creating products in space that can be utilized for terrestrial applications, leveraging the advantages of low gravity. Varda aims to establish an infrastructure that facilitates the harvesting of materials from space, particularly through asteroid mining, to produce new products. The founders of the company are Delian Asparouhov and Trae Stephens.

Deepcell

Series A in 2020
Deepcell, Inc. is a company based in Mountain View, California, focused on advancing diagnostic technologies through a non-invasive approach. Founded in 2015, it has developed a microfluidic imaging platform that leverages artificial intelligence to classify cells by their visual features. This technology allows for the isolation of viable cells based on their morphological characteristics, facilitating detailed genetic health assessments from standard blood samples. By enabling insights at the single-cell level, Deepcell aims to improve the diagnosis and treatment of various diseases, offering researchers a valuable alternative to invasive diagnostic methods.

Kenota Inc.

Series A in 2020
Kenota Health develops next-generation rapid point-of-care system intended to be used for allergy testing in humans. Kenota's diagnostic tools are safe, simple, and offer a cheaper alternative to allergy testing using a thorough non-invasive technology, enabling physicians to improve patient outcomes.

64x Bio

Seed Round in 2020
64x Bio is a biotechnology company based in San Francisco, California, founded in 2017 by Alexis Rovner, George Church, Jeffrey Way, and Pamela Silver. The company specializes in designing microorganisms with enhanced properties to facilitate advanced applications in biomanufacturing, bioremediation, and health. By creating cells tailored for specific purposes, 64x Bio aims to enable innovative solutions that were previously unattainable in these fields.

Brightseed

Venture Round in 2020
Brightseed, Inc. is a biotechnology company that specializes in discovering clinically beneficial molecules found in plants through its innovative Forager platform. Founded in 2017 and based in San Francisco, California, the company employs artificial intelligence and machine learning algorithms to screen plant genes, identifying the most effective sources for addressing various health conditions. By uncovering naturally occurring compounds with potential health benefits, Brightseed aims to enhance the quality of life and support chronic disease management. The company’s mission is to strengthen the connection between people and plants, ultimately facilitating a healthier future for individuals and communities.

Manifold Bio

Seed Round in 2020
Manifold Biotechnologies, Inc. is a biotechnology company that specializes in developing platforms for the pharmacological measurement of various therapeutic protein variants. By integrating DNA technologies with machine learning, the company aims to create protein drugs that address challenging diseases. Manifold Bio's innovative approach includes a protein barcoding platform designed to enable multiplexed quantitation of protein therapeutics, thereby generating extensive data that enhances the drug development process. Founded in 2019 and located in Allston, Massachusetts, the company is focused on advancing measurement-driven design in the field of protein therapeutics.

Meati

Series A in 2020
Meati, also known as Emergy Foods, is a consumer goods company based in Boulder, Colorado, founded in 2016. The company specializes in producing whole muscle, nutritious plant-based meats designed to promote healthier lifestyles and environmental sustainability. By utilizing proprietary, clean technologies, Meati offers nutrient-dense meat alternatives that aim to appeal to a wide audience, ensuring that consumers can enjoy meals that are both good for their health and the planet.

Cover

Series A in 2020
Cover Technologies Inc. specializes in the design, manufacturing, and installation of prefabricated homes, with a particular focus on custom backyard structures such as studios, home offices, guest houses, and hobby spaces. Founded in 2014 and based in Gardena, California, Cover employs proprietary design software and a precision manufacturing system to create energy-efficient and well-designed living spaces. The company aims to make thoughtfully built homes accessible to a broader audience, offering a streamlined process that significantly reduces the time required for traditional construction. Cover has initiated operations in Los Angeles and is currently accepting pre-orders for its products worldwide.

Geltor

Series B in 2020
Geltor, Inc. produces bioactive animal free collagens and other proteins for beauty, nutrition, and other applications. It offers Collume, a bio-designed collagen technology for skincare cellular regeneration, protection, and derma-collagen synthesis; and HumaColl21, a collagen product that delivers collagen, elastin, laminin, and fibronectin boosting effect for skin care. The company also provides vegan collagen peptides and other novel proteins for functional food and nutraceutical formulas. Geltor, Inc. was incorporated in 2015 and is based in San Leandro, California.

Ansa Biotechnologies

Seed Round in 2020
Ansa Biotechnologies, Inc. is a biotechnology company based in Berkeley, California, focused on developing innovative DNA synthesis technology utilizing enzymes. Established in 2018, the company aims to improve upon traditional chemical methods of DNA synthesis that have remained largely unchanged for decades. Ansa's enzymatic approach offers significant advantages, including increased speed, accuracy, and cleanliness in the production of DNA fragments such as oligonucleotides. This technology enhances the capabilities of biological research, therapeutics, diagnostics, and biomanufacturing by enabling the synthesis of gene-length oligonucleotides. Through its advancements, Ansa Biotechnologies seeks to facilitate innovation in the fields of biological research and engineering, ultimately providing valuable services to medical researchers and contributing to the broader biotechnology landscape.

Octant Bio

Series A in 2020
Octant Bio is focused on advancing health and treating complex diseases through innovative synthetic technology. The company utilizes a combination of synthetic biology, genome engineering, next-generation sequencing, and computational methods to assess the activity of numerous receptor pathways within human cells. This approach allows for the development of multi-targeted small molecule drug leads by leveraging machine learning to engineer compounds that interact with multiple receptors. By generating extensive multi-receptor pathway data, Octant Bio aims to enhance rational drug design and uncover new therapeutic possibilities. Founded in 2017 and based in Los Angeles, California, Octant Bio is dedicated to transforming the landscape of drug discovery and development.

Manifold Bio

Pre Seed Round in 2020
Manifold Biotechnologies, Inc. is a biotechnology company that specializes in developing platforms for the pharmacological measurement of various therapeutic protein variants. By integrating DNA technologies with machine learning, the company aims to create protein drugs that address challenging diseases. Manifold Bio's innovative approach includes a protein barcoding platform designed to enable multiplexed quantitation of protein therapeutics, thereby generating extensive data that enhances the drug development process. Founded in 2019 and located in Allston, Massachusetts, the company is focused on advancing measurement-driven design in the field of protein therapeutics.

54gene

Series A in 2020
54gene develops a pan-African biobank to identify new drug targets, and develop diagnostics and treatments for diseases. The company targets multiple disease states, including cancer, cardiovascular disease, and neuro-degenerative disease. It also provides genetic testing and molecular diagnostics services. The company was founded in 2019 and is based in San Francisco, California with an additional offices in Lagos, Nigeria.

Rebellyous Foods

Series A in 2020
Rebellyous Foods is a food manufacturing technology and production company defined solely to catapult meat alternative production toward price parity with animal-based meat. Rebellyous Foods implements novel food manufacturing equipment and processes in large-scale production to produce low-cost plant-based meat at high volumes. These goals are achieved through uniquely designed food products, the use of high-throughput manufacturing automation and ‘smart’ production centers, and the development and utilization of new innovative low-energy manufacturing tools. Working closely with industry partners, Rebellyous Foods makes plant-based meat sustainable, affordable, and widely available.

Catalog

Series A in 2020
Catalog Technologies Inc. is a Boston-based company that specializes in a DNA-based platform designed for digital data storage and computation. Founded in 2016, Catalog's innovative platform encodes digital information into DNA, providing a new approach to long-term data archiving. This method not only enhances data storage capacity but also offers a cost-effective solution for managing vast amounts of information. By integrating advanced synthetic biology technologies, Catalog aims to revolutionize the way digital data is archived and processed, making DNA a viable medium for future data storage needs.

Microverse

Seed Round in 2020
Microverse Enterprises, Inc. is an online education platform founded in 2018 and based in San Francisco, California, specializing in training software developers. The company aims to educate and connect one million individuals with remote job opportunities by 2030. Microverse offers full-stack web development programs that utilize income share agreements, allowing students to pay tuition after securing employment. The platform emphasizes collaborative learning, where students from diverse backgrounds work in small distributed teams, engage in remote pair programming, and participate in open source and freelance projects. This approach fosters accountability and teamwork, enabling students to develop the skills necessary to become professional remote software developers while providing companies with access to a global talent pool.

BillionToOne

Series A in 2020
BillionToOne Inc. develops a genetic testing platform that detects and measures disease at the molecular level. It offers UNITY, a noninvasive prenatal screening that tests fetal cell-free DNA for cystic fibrosis and spinal muscular atrophy through a single sample of the mother's blood. The company serves doctors and expecting mothers. BillionToOne Inc. was incorporated in 2016 and is based in Menlo Park, California.

Astranis

Series B in 2020
Astranis Space Technologies Corp. is a San Francisco-based company that designs and manufactures small telecommunications satellites aimed at enhancing Internet connectivity. Founded in 2015, Astranis specializes in its MicroGEO technology for geostationary orbit, enabling efficient data transmission to specific terrestrial locations. The company's primary mission is to bridge the digital divide by providing high-speed, reliable internet access to underserved regions at a significantly lower cost than traditional methods. By focusing on connecting the four billion people worldwide who currently lack internet access, Astranis aims to empower governments and businesses to expand internet connectivity and facilitate communication across the globe.

Advano

Series A in 2020
Advano, operating under NanoStar, Inc., is a New Orleans-based company specializing in silicon nanotechnology. Founded in 2014, Advano develops and produces functionalized silicon nanoparticles and quantum dots for various applications. Notably, its products enhance the energy density of lithium-ion batteries by 30-40%, making them suitable for electric vehicles, consumer electronics, and IoT devices, all without compromising battery life or increasing costs. Additionally, Advano's technology is applied in CO2 carbon capture, super hydrophobic coatings, and printable electronics, serving industries such as telecommunications.

UPSIDE Foods

Series B in 2020
UPSIDE Foods, formerly known as Memphis Meats, is a company headquartered in San Francisco, California, that specializes in producing cultured meat directly from animal cells. Founded in 2015 by Uma Valeti and Nicholas Genovese, the company focuses on developing products such as hot dogs, sausages, burgers, and meatballs without the need to raise and slaughter animals. This innovative approach to meat production requires significantly less caloric input, water, land, and energy compared to traditional methods, while also aiming to provide consumers with cleaner meat products that are free from harmful chemicals.

Arpeggio

Seed Round in 2020
Arpeggio Biosciences, Inc. is a biotechnology company based in Boulder, Colorado, founded in 2017. It specializes in developing software that captures and analyzes cellular RNA activity through a unique combination of biological assays and machine learning algorithms. This technology allows for low-depth sequencing to generate high-resolution snapshots of cellular dynamics in response to drug treatments. By revealing the biological networks that influence a drug's function, Arpeggio's platform aids pharmaceutical and biotechnology companies in understanding the mechanisms behind therapeutics. The company’s approach enhances the identification of new drug targets and increases the likelihood of success in clinical advancements. Arpeggio Biosciences is composed of a diverse team of molecular biologists, computer scientists, and biotechnology enthusiasts dedicated to advancing the understanding of drug mechanisms.

Rad AI

Seed Round in 2019
Rad AI empowers radiologists for the future.

Lively

Series B in 2019
Lively is a modern Health Savings Account (HSA) platform for employers and individuals. Lively’s user-centric solution creates an intuitive user experience allowing consumers to get the most out of their HSA.

Microverse

Seed Round in 2019
Microverse Enterprises, Inc. is an online education platform founded in 2018 and based in San Francisco, California, specializing in training software developers. The company aims to educate and connect one million individuals with remote job opportunities by 2030. Microverse offers full-stack web development programs that utilize income share agreements, allowing students to pay tuition after securing employment. The platform emphasizes collaborative learning, where students from diverse backgrounds work in small distributed teams, engage in remote pair programming, and participate in open source and freelance projects. This approach fosters accountability and teamwork, enabling students to develop the skills necessary to become professional remote software developers while providing companies with access to a global talent pool.

Brave Care

Seed Round in 2019
Brave Care, Inc. is a healthcare provider specializing in urgent pediatric services. Founded in 2017 and based in Portland, Oregon, the company operates clinics that address a variety of childhood illnesses and injuries. Services offered include treatment for allergies, asthma, coughs, ear pain, eye problems, fever, and urinary tract infections. Brave Care also provides care for minor fractures, strains, sprains, and head trauma, along with pediatric-specific laboratory services and on-site x-ray capabilities. The clinics are equipped to perform procedures such as stitches and tissue glue application for wound closure, as well as mild sedation for uncomfortable treatments.

Earth AI

Series A in 2019
Earth AI Pty Ltd. is an innovative mineral exploration company based in Parramatta, Australia, founded in 2016. The company specializes in developing artificial intelligence-based software that identifies potential areas of mineralization in remote locations lacking pre-existing geological data. By using AI mineral targeting technology, Earth AI provides geologists with location suggestions for mineral exposure and automatically generates detailed geological maps from satellite, geophysical, and geochemical datasets. This approach allows Earth AI to discover new metal deposits valued between $10 million and $100 million significantly faster and at a lower cost than traditional methods. The company's field-proven system is reported to be 50 times more successful in identifying mineralized prospects and achieves five times cheaper field operations through hardware automation and streamlined processes. Earth AI focuses on various metals, including copper, lead, zinc, nickel, cobalt, vanadium, and rare earth elements, effectively enhancing the chances of successful mineral discovery while minimizing operational risks and expenses.

Nurx

Series C in 2019
Nurx Inc. is a healthcare services company that operates a mobile health platform designed to provide easy access to a variety of everyday medications, including contraceptives, travel medications, and treatments for sexual health issues. The platform offers services such as doctor prescription and review, home HPV screening tests, and at-home STI testing. Users can manage their healthcare needs conveniently, with options for automatic prescription refills and renewals, all without the necessity of in-person consultations. Nurx aims to empower individuals, particularly women, by offering transparent pricing and judgment-free care, allowing them to take control of their health decisions. The company serves residents across multiple states, including California, Florida, New York, and Texas. Founded in 2015 and based in San Francisco, Nurx emphasizes personalized care through specialized providers and innovative technology.

Earth AI

Seed Round in 2019
Earth AI Pty Ltd. is an innovative mineral exploration company based in Parramatta, Australia, founded in 2016. The company specializes in developing artificial intelligence-based software that identifies potential areas of mineralization in remote locations lacking pre-existing geological data. By using AI mineral targeting technology, Earth AI provides geologists with location suggestions for mineral exposure and automatically generates detailed geological maps from satellite, geophysical, and geochemical datasets. This approach allows Earth AI to discover new metal deposits valued between $10 million and $100 million significantly faster and at a lower cost than traditional methods. The company's field-proven system is reported to be 50 times more successful in identifying mineralized prospects and achieves five times cheaper field operations through hardware automation and streamlined processes. Earth AI focuses on various metals, including copper, lead, zinc, nickel, cobalt, vanadium, and rare earth elements, effectively enhancing the chances of successful mineral discovery while minimizing operational risks and expenses.

Advano

Series A in 2019
Advano, operating under NanoStar, Inc., is a New Orleans-based company specializing in silicon nanotechnology. Founded in 2014, Advano develops and produces functionalized silicon nanoparticles and quantum dots for various applications. Notably, its products enhance the energy density of lithium-ion batteries by 30-40%, making them suitable for electric vehicles, consumer electronics, and IoT devices, all without compromising battery life or increasing costs. Additionally, Advano's technology is applied in CO2 carbon capture, super hydrophobic coatings, and printable electronics, serving industries such as telecommunications.

Ethic

Series A in 2019
Ethic operates as a tech-driven asset manager that powers the creation of investment portfolios. It builds separately managed accounts (SMAs) optimized to track the market, align with one’s investment allocation, and outperform on a client’s chosen sustainability criteria. The company was founded in 2015 and is headquartered in New York, United States.

Meati

Venture Round in 2019
Meati, also known as Emergy Foods, is a consumer goods company based in Boulder, Colorado, founded in 2016. The company specializes in producing whole muscle, nutritious plant-based meats designed to promote healthier lifestyles and environmental sustainability. By utilizing proprietary, clean technologies, Meati offers nutrient-dense meat alternatives that aim to appeal to a wide audience, ensuring that consumers can enjoy meals that are both good for their health and the planet.

Substack

Series A in 2019
Substack Inc. is an online platform that facilitates the creation and publication of both paid and free subscription newsletters for writers. Founded in 2017 and based in San Francisco, the company provides tools that enable writers to simultaneously publish content to an email list and a website while managing subscriber payments. Substack's all-in-one solution is designed to simplify the process of monetizing writing, offering user-friendly editing software, customizable templates, and features that help stories reach broader audiences beyond subscription paywalls. This approach allows writers to connect directly with their readers and generate revenue through their newsletters.

54gene

Seed Round in 2019
54gene develops a pan-African biobank to identify new drug targets, and develop diagnostics and treatments for diseases. The company targets multiple disease states, including cancer, cardiovascular disease, and neuro-degenerative disease. It also provides genetic testing and molecular diagnostics services. The company was founded in 2019 and is based in San Francisco, California with an additional offices in Lagos, Nigeria.

Solugen

Series B in 2019
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

unspun

Seed Round in 2019
Unspun, Inc. is a technology-driven company based in San Francisco, California, specializing in the production of customized jeans using advanced body scanning technology and fit algorithms. Founded in 2015, Unspun aims to revolutionize the apparel industry by reducing global carbon emissions through automated and localized manufacturing processes. The company offers a B2B software platform that enables digital customization for various large apparel brands. Recognized for its innovation, Unspun's technology was featured in TIME's list of Best Inventions of 2019. The company is supported by several notable investors and is actively working on the future of additive and automated apparel production, positioning itself as a leader in the quest for sustainable fashion.

Kin Euphorics

Venture Round in 2019
Kin Euphorics is a New York-based company, founded in 2017, that specializes in non-alcoholic beverages designed to enhance social experiences. The company's offerings include ready-to-drink tonics made from a combination of nootropics, adaptogens, and botanicals. These functional beverages aim to promote a sense of focused relaxation, helping consumers unwind without inducing sleepiness or compromising cognitive function. Kin Euphorics targets individuals seeking a balanced and nourishing alternative to traditional alcoholic drinks, allowing them to enjoy social interactions while supporting their mental well-being.

Boundary Layer Technologies

Seed Round in 2019
Boundary Layer Technologies is a startup established in 2018 that specializes in the development of high-speed container ships utilizing hydrofoil technology. This innovative approach allows the vessels to generate lift, elevating the hull above the water and significantly reducing drag. As a result, these ships offer a faster alternative for the logistics industry, particularly in ocean freight, compared to traditional methods. By focusing on enhancing delivery speeds, Boundary Layer Technologies aims to disrupt the existing airfreight market and provide a more efficient solution for transporting shipments across oceans.

BillionToOne

Series A in 2019
BillionToOne Inc. develops a genetic testing platform that detects and measures disease at the molecular level. It offers UNITY, a noninvasive prenatal screening that tests fetal cell-free DNA for cystic fibrosis and spinal muscular atrophy through a single sample of the mother's blood. The company serves doctors and expecting mothers. BillionToOne Inc. was incorporated in 2016 and is based in Menlo Park, California.

Quantstamp

Seed Round in 2019
Quantstamp, Inc. is a company that specializes in enhancing the security of blockchain technology. Founded in 2017 and based in Dover, Delaware, Quantstamp develops scalable security-audit solutions for blockchain developers and projects. The company's software is designed to monitor and audit various components of decentralized applications, including smart contracts, off-chain activities, networking, and front-end interfaces. By providing thorough security assessments, Quantstamp enables users to implement rigorous auditing processes for their blockchain projects, ensuring they are well-prepared for launch and future developments.

Rebellyous Foods

Seed Round in 2018
Rebellyous Foods is a food manufacturing technology and production company defined solely to catapult meat alternative production toward price parity with animal-based meat. Rebellyous Foods implements novel food manufacturing equipment and processes in large-scale production to produce low-cost plant-based meat at high volumes. These goals are achieved through uniquely designed food products, the use of high-throughput manufacturing automation and ‘smart’ production centers, and the development and utilization of new innovative low-energy manufacturing tools. Working closely with industry partners, Rebellyous Foods makes plant-based meat sustainable, affordable, and widely available.

Ansa Biotechnologies

Pre Seed Round in 2018
Ansa Biotechnologies, Inc. is a biotechnology company based in Berkeley, California, focused on developing innovative DNA synthesis technology utilizing enzymes. Established in 2018, the company aims to improve upon traditional chemical methods of DNA synthesis that have remained largely unchanged for decades. Ansa's enzymatic approach offers significant advantages, including increased speed, accuracy, and cleanliness in the production of DNA fragments such as oligonucleotides. This technology enhances the capabilities of biological research, therapeutics, diagnostics, and biomanufacturing by enabling the synthesis of gene-length oligonucleotides. Through its advancements, Ansa Biotechnologies seeks to facilitate innovation in the fields of biological research and engineering, ultimately providing valuable services to medical researchers and contributing to the broader biotechnology landscape.

Lively

Series A in 2018
Lively is a modern Health Savings Account (HSA) platform for employers and individuals. Lively’s user-centric solution creates an intuitive user experience allowing consumers to get the most out of their HSA.

Geltor

Series A in 2018
Geltor, Inc. produces bioactive animal free collagens and other proteins for beauty, nutrition, and other applications. It offers Collume, a bio-designed collagen technology for skincare cellular regeneration, protection, and derma-collagen synthesis; and HumaColl21, a collagen product that delivers collagen, elastin, laminin, and fibronectin boosting effect for skin care. The company also provides vegan collagen peptides and other novel proteins for functional food and nutraceutical formulas. Geltor, Inc. was incorporated in 2015 and is based in San Leandro, California.

Solugen

Series A in 2018
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Garten

Seed Round in 2018
Garten, Inc. distributes vegan, gluten free, organic, and non GMO food products for individuals and offices in Silicon Valley, California. The company offers healthy snacks, coffee and tea, fresh produce, beverages, dairy products, and equipment. It also provides a slack wellness application that enables employees behavior across nutrition, rest, yoga, meditate, exercise, detox, and emotional wellbeing dimensions. Garten, Inc. was formerly known as Oh My Green, Inc. and changed its name to Garten, Inc. in June, 2020. The company was incorporated in 2014 and is based in San Mateo, California.

Atom Computing

Seed Round in 2018
Atom Computing Inc. is a company based in Berkeley, California, that focuses on manufacturing scalable quantum computers utilizing individual atoms. Founded in 2018, the company harnesses the quantum mechanical properties of atoms to process information and address complex problems that traditional computers cannot solve. Atom Computing's technology allows for the optical control, scaling, and stabilization of these atoms, facilitating efficient quantum calculations in various fields, including drug design, computational chemistry, and general computing. Through its innovative approach, Atom Computing aims to advance the development of quantum technology and expand its applications across multiple industries.

Tierra Biosciences

Seed Round in 2018
Tierra Biosciences is a biotechnology company that specializes in developing cell-free technologies to facilitate the discovery of challenging molecules that traditional laboratory cell methods struggle to produce. Utilizing automation, computation, and high-throughput cell-free expression techniques, the company enables the expression of DNA from various microbial sources. Its Next Generation Expression platform enhances bio-discovery by allowing for rapid and experimentally validated data collection. Founded in 2015 and originally named Synvitrobio, the company rebranded to Tierra Biosciences in September 2018. It is headquartered in San Francisco, California.

Tierra Biosciences

Seed Round in 2018
Tierra Biosciences is a biotechnology company that specializes in developing cell-free technologies to facilitate the discovery of challenging molecules that traditional laboratory cell methods struggle to produce. Utilizing automation, computation, and high-throughput cell-free expression techniques, the company enables the expression of DNA from various microbial sources. Its Next Generation Expression platform enhances bio-discovery by allowing for rapid and experimentally validated data collection. Founded in 2015 and originally named Synvitrobio, the company rebranded to Tierra Biosciences in September 2018. It is headquartered in San Francisco, California.

Mylk Guys

Seed Round in 2018
Mylk Guys, Inc. is an online vegan grocery store based in San Francisco, California, established in 2018. The company specializes in a wide range of plant-based products, including bakery items, cheese, frozen foods, pantry staples, prepared meals, desserts, and snacks. Mylk Guys offers consumers the convenience of purchasing natural and plant-based foods from both local and national brands, delivering these items directly to their doorsteps. The marketplace emphasizes a diverse selection that caters to the growing demand for vegan and health-conscious options.

Lygos

Series B in 2018
Lygos is a biotechnology company focused on providing sustainable solutions for renewable chemical production. Founded in 2011 and headquartered in Berkeley, California, Lygos engineers microbes to convert sugars into high-value industrial chemicals, emphasizing cost-effectiveness compared to traditional petrochemical processes. By utilizing advanced throughput screening and strain construction techniques, the company rapidly optimizes biological pathways to transform inexpensive and renewable feedstock into valuable chemical products. Lygos aims to replace persistent and often toxic chemicals with cleaner, more efficient alternatives, catering to business-to-business customers and fostering high-performing, sustainable solutions across the chemical industry.

Nurx

Series B in 2018
Nurx Inc. is a healthcare services company that operates a mobile health platform designed to provide easy access to a variety of everyday medications, including contraceptives, travel medications, and treatments for sexual health issues. The platform offers services such as doctor prescription and review, home HPV screening tests, and at-home STI testing. Users can manage their healthcare needs conveniently, with options for automatic prescription refills and renewals, all without the necessity of in-person consultations. Nurx aims to empower individuals, particularly women, by offering transparent pricing and judgment-free care, allowing them to take control of their health decisions. The company serves residents across multiple states, including California, Florida, New York, and Texas. Founded in 2015 and based in San Francisco, Nurx emphasizes personalized care through specialized providers and innovative technology.

Geltor

Series A in 2018
Geltor, Inc. produces bioactive animal free collagens and other proteins for beauty, nutrition, and other applications. It offers Collume, a bio-designed collagen technology for skincare cellular regeneration, protection, and derma-collagen synthesis; and HumaColl21, a collagen product that delivers collagen, elastin, laminin, and fibronectin boosting effect for skin care. The company also provides vegan collagen peptides and other novel proteins for functional food and nutraceutical formulas. Geltor, Inc. was incorporated in 2015 and is based in San Leandro, California.

Skip Scooters

Series A in 2018
Skip Scooters operates shared electric scooters for reliable last-mile transportation. The company works with cities to ensure our fleets are operated with the support of the surrounding communities, and they stand behind their riders by providing vehicles, safety education, and training, and world-class support. The scooter rental company is based in San Francisco, California. It is formerly known by its Y Combinator codename, Waybots.
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