PTV Healthcare Capital

PTV Healthcare Capital is a Texas-based venture capital firm founded in 2003, specializing in investments in growth-stage companies within the healthcare sector. The firm is based in Austin and comprises a team of professionals with extensive experience in both investing and operating life science companies. PTV focuses on mid-to-late stage companies that present lower technical, regulatory, and financial risks, aligning with healthcare economics to enhance patient outcomes while reducing costs. The firm targets markets with significant unmet clinical needs, aiming to support healthcare entrepreneurs and foster global innovation.

Matt Crawford

Founding Managing Director

34 past transactions

Cardiva Medical

Debt Financing in 2018
Cardiva Medical, Inc. is a medical device company that specializes in vascular access management products aimed at facilitating the body's natural healing process after percutaneous catheterization procedures. Its product lineup includes VASCADE VCS, a bioabsorbable femoral access closure system that promotes rapid hemostasis and reduces complications. Additionally, Cardiva offers the Catalyst manual compression assistance device, which supports temporary hemostasis and improves coagulation for patients needing manual compression. The company also manufactures VASCADE MVP, a vascular closure system for multi-site venous closure during electrophysiology procedures such as cardiac ablation. Founded in 2002 and headquartered in Santa Clara, California, Cardiva Medical serves physicians and cardiac centers across the United States.

Intuity Medical

Debt Financing in 2018
Intuity Medical develops blood glucose monitoring systems for diabetes management. Their POGO Automatic Blood Glucose Monitoring System is the world’s first FDA-cleared automatic, one-step blood glucose meter that combines lancing, blood collection, and analysis into a single 10-test cartridge. It provides a convenient and discreet solution for millions of patients who need to regularly test their blood glucose. The company was founded in 2002 and is headquartered in Fremont, California.

Cardiva Medical

Venture Round in 2017
Cardiva Medical, Inc. is a medical device company that specializes in vascular access management products aimed at facilitating the body's natural healing process after percutaneous catheterization procedures. Its product lineup includes VASCADE VCS, a bioabsorbable femoral access closure system that promotes rapid hemostasis and reduces complications. Additionally, Cardiva offers the Catalyst manual compression assistance device, which supports temporary hemostasis and improves coagulation for patients needing manual compression. The company also manufactures VASCADE MVP, a vascular closure system for multi-site venous closure during electrophysiology procedures such as cardiac ablation. Founded in 2002 and headquartered in Santa Clara, California, Cardiva Medical serves physicians and cardiac centers across the United States.

Intuity Medical

Venture Round in 2016
Intuity Medical develops blood glucose monitoring systems for diabetes management. Their POGO Automatic Blood Glucose Monitoring System is the world’s first FDA-cleared automatic, one-step blood glucose meter that combines lancing, blood collection, and analysis into a single 10-test cartridge. It provides a convenient and discreet solution for millions of patients who need to regularly test their blood glucose. The company was founded in 2002 and is headquartered in Fremont, California.

Apollo Endosurgery

Convertible Note in 2015
Apollo Endosurgery is a medical technology company specializing in the design, development, and commercialization of devices aimed at enhancing gastrointestinal therapeutic endoscopy. Founded in 2005 and headquartered in Austin, Texas, the company offers a range of products, including the OverStitch Endoscopic Suturing System and the Orbera intragastric balloon system. These devices enable physicians to perform advanced endoscopic procedures, such as placing full-thickness sutures and reducing stomach capacity to aid in weight loss. Additionally, Apollo provides aftercare support through the Orbera Coach program. The company's products are utilized by gastroenterologists and bariatric surgeons across the United States, Brazil, Australia, and various European countries, addressing conditions like gastrointestinal perforations, chronic fistulas, and abnormal lesions. Apollo Endosurgery's innovations are rooted in collaboration with a network of leading gastroenterologists and surgeons who have sought to advance the field of therapeutic flexible endoscopy since 1998.

Cardiva Medical

Venture Round in 2014
Cardiva Medical, Inc. is a medical device company that specializes in vascular access management products aimed at facilitating the body's natural healing process after percutaneous catheterization procedures. Its product lineup includes VASCADE VCS, a bioabsorbable femoral access closure system that promotes rapid hemostasis and reduces complications. Additionally, Cardiva offers the Catalyst manual compression assistance device, which supports temporary hemostasis and improves coagulation for patients needing manual compression. The company also manufactures VASCADE MVP, a vascular closure system for multi-site venous closure during electrophysiology procedures such as cardiac ablation. Founded in 2002 and headquartered in Santa Clara, California, Cardiva Medical serves physicians and cardiac centers across the United States.

Intersect ENT

Series D in 2013
Intersect ENT is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions in the United States. The company specializes in drug delivery products, including the PROPEL and PROPEL mini drug-releasing implants, designed for individuals undergoing sinus surgery to address chronic sinusitis. Additionally, it offers PROPEL Contour, a steroid-releasing implant aimed at treating frontal and maxillary sinus ostia. Intersect ENT also provides SINUVA, a steroid-releasing implant intended for use in the physician's office for patients with refractory disease. Founded in 2003 and headquartered in Menlo Park, California, the company was previously known as Sinexus before rebranding in 2009.

Tryton Medical

Venture Round in 2013
Tryton Medical, Inc. is a medical device company based in Durham, North Carolina, specializing in the development and manufacturing of side branch stent systems designed to treat coronary bifurcation lesions in patients with cardiovascular diseases. Founded in 2003, the company provides its innovative Tryton Side Branch Stent System, which targets atherosclerotic lesions at bifurcation sites. Tryton Medical distributes its products through a global network of distributors and also addresses investigational needs within the United States. The company's offerings are available in several countries, including Austria, Belgium, Denmark, Ireland, Luxembourg, the Netherlands, Norway, Poland, Portugal, Spain, and the United Kingdom.

Mirna Therapeutics

Series C in 2012
Mirna Therapeutics, Inc. is a discovery-stage biopharmaceutical company that specializes in developing miRNA-directed therapies for human oncology. With a strong focus on research and a deep understanding of microRNA and cancer biology, Mirna is positioned to advance the emerging field of miRNA-based therapeutics. The company boasts a robust intellectual property portfolio that supports its innovative approach to cancer treatment.

Cardiva Medical

Venture Round in 2012
Cardiva Medical, Inc. is a medical device company that specializes in vascular access management products aimed at facilitating the body's natural healing process after percutaneous catheterization procedures. Its product lineup includes VASCADE VCS, a bioabsorbable femoral access closure system that promotes rapid hemostasis and reduces complications. Additionally, Cardiva offers the Catalyst manual compression assistance device, which supports temporary hemostasis and improves coagulation for patients needing manual compression. The company also manufactures VASCADE MVP, a vascular closure system for multi-site venous closure during electrophysiology procedures such as cardiac ablation. Founded in 2002 and headquartered in Santa Clara, California, Cardiva Medical serves physicians and cardiac centers across the United States.

Apollo Endosurgery

Series B in 2012
Apollo Endosurgery is a medical technology company specializing in the design, development, and commercialization of devices aimed at enhancing gastrointestinal therapeutic endoscopy. Founded in 2005 and headquartered in Austin, Texas, the company offers a range of products, including the OverStitch Endoscopic Suturing System and the Orbera intragastric balloon system. These devices enable physicians to perform advanced endoscopic procedures, such as placing full-thickness sutures and reducing stomach capacity to aid in weight loss. Additionally, Apollo provides aftercare support through the Orbera Coach program. The company's products are utilized by gastroenterologists and bariatric surgeons across the United States, Brazil, Australia, and various European countries, addressing conditions like gastrointestinal perforations, chronic fistulas, and abnormal lesions. Apollo Endosurgery's innovations are rooted in collaboration with a network of leading gastroenterologists and surgeons who have sought to advance the field of therapeutic flexible endoscopy since 1998.

Cardiva Medical

Venture Round in 2011
Cardiva Medical, Inc. is a medical device company that specializes in vascular access management products aimed at facilitating the body's natural healing process after percutaneous catheterization procedures. Its product lineup includes VASCADE VCS, a bioabsorbable femoral access closure system that promotes rapid hemostasis and reduces complications. Additionally, Cardiva offers the Catalyst manual compression assistance device, which supports temporary hemostasis and improves coagulation for patients needing manual compression. The company also manufactures VASCADE MVP, a vascular closure system for multi-site venous closure during electrophysiology procedures such as cardiac ablation. Founded in 2002 and headquartered in Santa Clara, California, Cardiva Medical serves physicians and cardiac centers across the United States.

Intersect ENT

Series C in 2010
Intersect ENT is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions in the United States. The company specializes in drug delivery products, including the PROPEL and PROPEL mini drug-releasing implants, designed for individuals undergoing sinus surgery to address chronic sinusitis. Additionally, it offers PROPEL Contour, a steroid-releasing implant aimed at treating frontal and maxillary sinus ostia. Intersect ENT also provides SINUVA, a steroid-releasing implant intended for use in the physician's office for patients with refractory disease. Founded in 2003 and headquartered in Menlo Park, California, the company was previously known as Sinexus before rebranding in 2009.

IDEV Technologies

Series D in 2010
IDEV Technologies is an emerging growth medical device company focused on the development of products for endovascular and interventional applications. Currently, IDEV markets SUPERA, a novel self-expanding nitinol stent. Using a patented interwoven design, SUPERA offers improved flexibility, radial strength, and kink and crush resistance compared to other marketed stents. SUPERA is currently approved for use in the treatment of biliary strictures in the US. IDEV is currently enrolling patients in the SUPERB IDE trial to study SUPERA's safety and efficacy when used in the superficial femoral artery (SFA).

Tryton Medical

Series D in 2010
Tryton Medical, Inc. is a medical device company based in Durham, North Carolina, specializing in the development and manufacturing of side branch stent systems designed to treat coronary bifurcation lesions in patients with cardiovascular diseases. Founded in 2003, the company provides its innovative Tryton Side Branch Stent System, which targets atherosclerotic lesions at bifurcation sites. Tryton Medical distributes its products through a global network of distributors and also addresses investigational needs within the United States. The company's offerings are available in several countries, including Austria, Belgium, Denmark, Ireland, Luxembourg, the Netherlands, Norway, Poland, Portugal, Spain, and the United Kingdom.

Ortho Kinematics

Series A in 2010
Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.

Ortho Kinematics

Venture Round in 2009
Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.

Alereon

Venture Round in 2008
Alereon is a fabless semiconductor company developing innovative Ultrawideband (UWB) wireless chipsets. Their mission is to simplify networking by removing cables, allowing effortless connections between PCs, consumer electronics, peripherals and mobile devices. We want to change the way consumers connect to the world.

Cameron Health

Series E in 2008
Cameron Health, Inc. is a development stage medical device company focused on creating advanced implantable electronic devices. The company specializes in the development of the subcutaneous implantable defibrillator (S-ICD) system, designed to protect patients from sudden cardiac arrest. By leveraging state-of-the-art technologies and a team of experienced professionals, Cameron Health aims to address complex medical challenges and provide innovative treatment options that have been previously unattainable with existing therapies.

Intersect ENT

Series B in 2008
Intersect ENT is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions in the United States. The company specializes in drug delivery products, including the PROPEL and PROPEL mini drug-releasing implants, designed for individuals undergoing sinus surgery to address chronic sinusitis. Additionally, it offers PROPEL Contour, a steroid-releasing implant aimed at treating frontal and maxillary sinus ostia. Intersect ENT also provides SINUVA, a steroid-releasing implant intended for use in the physician's office for patients with refractory disease. Founded in 2003 and headquartered in Menlo Park, California, the company was previously known as Sinexus before rebranding in 2009.

Cardiva Medical

Series D in 2008
Cardiva Medical, Inc. is a medical device company that specializes in vascular access management products aimed at facilitating the body's natural healing process after percutaneous catheterization procedures. Its product lineup includes VASCADE VCS, a bioabsorbable femoral access closure system that promotes rapid hemostasis and reduces complications. Additionally, Cardiva offers the Catalyst manual compression assistance device, which supports temporary hemostasis and improves coagulation for patients needing manual compression. The company also manufactures VASCADE MVP, a vascular closure system for multi-site venous closure during electrophysiology procedures such as cardiac ablation. Founded in 2002 and headquartered in Santa Clara, California, Cardiva Medical serves physicians and cardiac centers across the United States.

IDEV Technologies

Series C in 2008
IDEV Technologies is an emerging growth medical device company focused on the development of products for endovascular and interventional applications. Currently, IDEV markets SUPERA, a novel self-expanding nitinol stent. Using a patented interwoven design, SUPERA offers improved flexibility, radial strength, and kink and crush resistance compared to other marketed stents. SUPERA is currently approved for use in the treatment of biliary strictures in the US. IDEV is currently enrolling patients in the SUPERB IDE trial to study SUPERA's safety and efficacy when used in the superficial femoral artery (SFA).

Accumetrics

Series D in 2008
Accumetrics is a privately-held company based in San Diego, California, specializing in the development, manufacturing, and marketing of the VerifyNow System. This system comprises a comprehensive suite of assays designed for the assessment of platelet function, which is crucial in various medical applications, particularly in cardiovascular care. Founded in 1996, Accumetrics was initially sold to Radiometer in 2000 but was repurchased by its management and investors in 2003. The company continues to focus on providing essential tools for healthcare professionals to improve patient outcomes through effective monitoring of platelet activity.

Asuragen

Series B in 2007
Asuragen, Inc. is a molecular diagnostics company based in Austin, Texas, specializing in patient management solutions for oncology and genetic disorders. Founded in 2005, Asuragen focuses on the development and commercialization of diagnostic products for clinical laboratories and pharmaceutical partners. Its product portfolio includes a variety of assays for cancer detection and genetic testing, such as the AmplideX FMR1 PCR reagents for fragile X syndrome and the Signature® line of tests for various cancer mutations. The company utilizes patented technologies, including Armored RNA®, to enhance the accuracy and reliability of its diagnostics. Additionally, Asuragen provides testing services and operates a cGMP manufacturing facility, enabling a comprehensive approach to molecular oncology that encompasses discovery, testing, production, and commercialization. Asuragen's commitment to innovation aids the medical community in improving treatment outcomes through precise diagnostic solutions.

Apollo Endosurgery

Series A in 2007
Apollo Endosurgery is a medical technology company specializing in the design, development, and commercialization of devices aimed at enhancing gastrointestinal therapeutic endoscopy. Founded in 2005 and headquartered in Austin, Texas, the company offers a range of products, including the OverStitch Endoscopic Suturing System and the Orbera intragastric balloon system. These devices enable physicians to perform advanced endoscopic procedures, such as placing full-thickness sutures and reducing stomach capacity to aid in weight loss. Additionally, Apollo provides aftercare support through the Orbera Coach program. The company's products are utilized by gastroenterologists and bariatric surgeons across the United States, Brazil, Australia, and various European countries, addressing conditions like gastrointestinal perforations, chronic fistulas, and abnormal lesions. Apollo Endosurgery's innovations are rooted in collaboration with a network of leading gastroenterologists and surgeons who have sought to advance the field of therapeutic flexible endoscopy since 1998.

LDR Holding

Series C in 2007
LDR Holding Corporation develops and markets implantable spine systems and instrumentation for patients and the surgeon community in the United States and internationally. Its spinal surgery solutions include cervical and lumbar artificial disc systems, pedicle screw systems, implant systems, cervical cages, synthetic bone substitutes, and ALIF and TLIF devices, as well as VerteBRIDGE product, a direct lateral and oblique lumbar system for surgical applications. The company offers its products through partnerships with surgeons and distributors in Australia, Argentina, Austria, Belgium, Denmark, Greece, the Netherlands, Italy, Japan, Korea, Mexico, Malaysia, Peru, Portugal, South Africa, Spain, China, Switzerland, Taiwan, Thailand, Turkey, and the United Kingdom. LDR Holding Corporation was formerly known as LDR Spine USA, Inc. and changed its name after acquiring LDR Médical. The company was founded in 2004 and is based in Austin, Texas with additional offices in Troyes, France; Beijing, China; Sao Paolo, Brazil; and Munich, Germany.

Alereon

Series B in 2007
Alereon is a fabless semiconductor company developing innovative Ultrawideband (UWB) wireless chipsets. Their mission is to simplify networking by removing cables, allowing effortless connections between PCs, consumer electronics, peripherals and mobile devices. We want to change the way consumers connect to the world.

On-X

Venture Round in 2007
On-X Life Technologies develops, manufactures, and offers artificial heart valve replacement and repair products. The company’s product portfolio includes Aortic Heart Valve with Standard Sewing Ring, Aortic Heart Valve with Conform-X Sewing Ring, Aortic Heart Valve with Anatomic Sewing Ring, Mitral Heart Valve with Standard Sewing Ring, Mitral Heart Valve with Conform-X Sewing Ring, Ascending Aortic Prosthesis, Chord-XTM ePTFE Suture, CO2 diffusion catheters, and more. On-X Life Technologies was incorporated in 1994 and is based in Austin, Texas.

BioSET

Venture Round in 2007
BioSET, Inc., founded in 2001 and based in Rockville, Maryland, specializes in the research and development of synthetic bioactive peptides for medical applications. The company focuses on creating proprietary therapeutic peptides and implantable devices designed to enhance bone and soft tissue repair, particularly in orthobiologics. Its flagship product, Amplex, is an implantable device that combines a peptide with a synthetic ceramic scaffold, serving as a surgical bone graft implant for various spinal and orthopedic surgeries, including lumbar degenerative disc disease and foot and ankle fusion procedures. Additionally, BioSET develops products for sports medicine and offers peptide signaling molecules along with diverse scaffold biomaterials to support musculoskeletal applications, including trauma and fracture repair. As of February 2015, BioSET operates as a subsidiary of Ferring Pharmaceuticals Inc.

LDR Holding

Series B in 2006
LDR Holding Corporation develops and markets implantable spine systems and instrumentation for patients and the surgeon community in the United States and internationally. Its spinal surgery solutions include cervical and lumbar artificial disc systems, pedicle screw systems, implant systems, cervical cages, synthetic bone substitutes, and ALIF and TLIF devices, as well as VerteBRIDGE product, a direct lateral and oblique lumbar system for surgical applications. The company offers its products through partnerships with surgeons and distributors in Australia, Argentina, Austria, Belgium, Denmark, Greece, the Netherlands, Italy, Japan, Korea, Mexico, Malaysia, Peru, Portugal, South Africa, Spain, China, Switzerland, Taiwan, Thailand, Turkey, and the United Kingdom. LDR Holding Corporation was formerly known as LDR Spine USA, Inc. and changed its name after acquiring LDR Médical. The company was founded in 2004 and is based in Austin, Texas with additional offices in Troyes, France; Beijing, China; Sao Paolo, Brazil; and Munich, Germany.

GlycoMimetics

Series B in 2006
GlycoMimetics, Inc. is a clinical-stage biotechnology company dedicated to the discovery and development of innovative glycomimetic drugs aimed at addressing significant unmet medical needs associated with diseases influenced by carbohydrate biology. The company’s lead drug candidate, rivipansel, is a pan-selectin antagonist that has completed Phase III clinical trials for treating vaso-occlusive crises in sickle cell disease. Additionally, GlycoMimetics is developing uproleselan, an E-selectin inhibitor that is being tested in combination with chemotherapy for acute myeloid leukemia (AML) and in a Phase III trial for relapsed/refractory AML. The company also offers GMI-1359, which targets E-selectin and a chemokine receptor, having completed Phase I clinical trials, and is involved in developing other candidates, including GMI-1687 and Galectin-3. GlycoMimetics has established research collaborations, including an agreement with the National Cancer Institute and a partnership with Apollomics for the commercialization of uproleselan and GMI-1687. Founded in 2003, the company is headquartered in Rockville, Maryland.

Biomimetic Therapeutics

Series C in 2005
BioMimetic Therapeutics is a biotechnology company focused on developing biologically active drug-device combination products that stimulate the body's natural tissue regenerative processes. Founded in 1999 and headquartered in Franklin, Tennessee, the company offers a range of products targeting various orthopedic and sports medicine conditions. These include Augment Injectable and Augment Rotator Cuff, which are designed for applications such as foot and ankle fusions, wrist fracture healing, and rotator cuff tear surgical treatment. Additionally, the Augment Tendinopathy Injection addresses injuries related to tendon overuse. Through its innovative approaches, BioMimetic Therapeutics aims to improve healing outcomes for patients with skeletal and associated tissue injuries.

GlycoMimetics

Series A in 2004
GlycoMimetics, Inc. is a clinical-stage biotechnology company dedicated to the discovery and development of innovative glycomimetic drugs aimed at addressing significant unmet medical needs associated with diseases influenced by carbohydrate biology. The company’s lead drug candidate, rivipansel, is a pan-selectin antagonist that has completed Phase III clinical trials for treating vaso-occlusive crises in sickle cell disease. Additionally, GlycoMimetics is developing uproleselan, an E-selectin inhibitor that is being tested in combination with chemotherapy for acute myeloid leukemia (AML) and in a Phase III trial for relapsed/refractory AML. The company also offers GMI-1359, which targets E-selectin and a chemokine receptor, having completed Phase I clinical trials, and is involved in developing other candidates, including GMI-1687 and Galectin-3. GlycoMimetics has established research collaborations, including an agreement with the National Cancer Institute and a partnership with Apollomics for the commercialization of uproleselan and GMI-1687. Founded in 2003, the company is headquartered in Rockville, Maryland.

Alereon

Series A in 2004
Alereon is a fabless semiconductor company developing innovative Ultrawideband (UWB) wireless chipsets. Their mission is to simplify networking by removing cables, allowing effortless connections between PCs, consumer electronics, peripherals and mobile devices. We want to change the way consumers connect to the world.
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