Bill & Melinda Gates Foundation

Phase Genomics, Inc. is a biotechnology company founded in 2015 and located in Seattle, Washington. The company specializes in advanced genomic technologies, particularly ProxiMeta Hi-C genome assembly and metagenome deconvolution. Its mission is to assist scientists in making significant discoveries by delivering highly complete and accurate genomes and metagenomes. Through its innovative approaches, Phase Genomics aims to enhance the understanding of complex biological systems, facilitating research in various fields of life sciences.

CRISPR Therapeutics AG is a gene editing company dedicated to developing transformative gene-based medicines for serious human diseases using its proprietary CRISPR/Cas9 technology. This revolutionary platform allows for precise modifications to genomic DNA, enabling the company to target a variety of disease areas, including hemoglobinopathies, oncology, regenerative medicine, and rare diseases. The lead product candidate, CTX001, is an ex vivo CRISPR gene-edited therapy aimed at treating transfusion-dependent beta thalassemia and severe sickle cell disease by engineering patients' hematopoietic stem cells to produce elevated levels of fetal hemoglobin. Additionally, CRISPR Therapeutics is advancing other therapies, including CTX110, an allogeneic CAR-T therapy for certain malignancies, and additional programs targeting conditions such as multiple myeloma, solid tumors, diabetes, and various genetic disorders. The company collaborates with strategic partners such as Bayer Healthcare, Vertex Pharmaceuticals, and ViaCyte, and is headquartered in Zug, Switzerland.

A-Alpha Bio, Inc., founded in 2017 and based in Seattle, Washington, specializes in synthetic biology with a focus on drug development that targets multiple proteins. The company's flagship platform, AlphaSeq, offers innovative cell-based tools for quantitative and high-throughput measurement of protein interactions. This technology accelerates processes such as target discovery, library screening, and preclinical drug characterization, addressing significant bottlenecks in the industry. By providing biologics and molecular glue discovery and optimization services, A-Alpha Bio supports pharmaceutical companies in enhancing binding and specificity for various target proteins. The team comprises experts in synthetic biology, structural biology, and next-generation sequencing, all dedicated to advancing drug discovery methodologies.

BioNTech is a biotechnology company focused on developing and commercializing immunotherapies for cancer and infectious diseases. Founded in 2008 and headquartered in Mainz, Germany, the company has pioneered innovative therapies through advanced computational discovery and drug development platforms. BioNTech's oncology pipeline includes various neoantigen-targeted therapies, such as NEO-PV-01 for advanced non-small cell lung cancer and multiple FixVac product candidates for different cancers, including melanoma, prostate cancer, and HPV-positive head and neck cancers. The company also explores mRNA vaccine candidates for infectious diseases and maintains collaborations with prominent pharmaceutical firms. BioNTech Cell & Gene Therapies GmbH, a subsidiary, specializes in developing T cell immunotherapies for cancer treatment.

Phase Genomics, Inc. is a biotechnology company founded in 2015 and located in Seattle, Washington. The company specializes in advanced genomic technologies, particularly ProxiMeta Hi-C genome assembly and metagenome deconvolution. Its mission is to assist scientists in making significant discoveries by delivering highly complete and accurate genomes and metagenomes. Through its innovative approaches, Phase Genomics aims to enhance the understanding of complex biological systems, facilitating research in various fields of life sciences.

Evolve Biosystems, Inc. is a biotechnology company based in Davis, California, that focuses on developing probiotic-based biotherapeutics aimed at establishing, restoring, and maintaining a healthy human microbiome. The company specializes in addressing gut dysbiosis across all stages of life, with particular emphasis on supporting the microbiome of newborn infants. Evolve Biosystems offers both consumer-directed home use products and hospital-based solutions for neonatal intensive care units. With a discovery platform that also addresses microbiome issues in production animals, the company aims to meet various unmet clinical needs. Founded in 2011, Evolve Biosystems is committed to advancing microbiome health through innovative probiotic solutions.

Boragen Inc. is a biotechnology company based in Durham, North Carolina, that specializes in designing and developing multifunctional small molecule boron solutions for applications in crop protection, animal health, and human health. Founded in 2015, the company focuses on creating next-generation fungicides through its synthetic chemistry platforms, which aim to promote sustainable farming practices. Boragen's product pipeline includes BAG8, a boron-based multisite fungicide, and BN2266, which targets mRNA processing as a crop protection fungicide. Additionally, the company is developing a dual-function nematicide-fungicide designed for root protection and endo-parasiticides that address resistance challenges. Through its innovative approach, Boragen seeks to enhance agricultural efficiency while minimizing chemical usage.

Batavia Biosciences is a biotechnology company that specializes in accelerating the development of biopharmaceutical products, including viral and bacterial vaccines, recombinant proteins, antibodies, and gene therapy products. The company offers a comprehensive range of services that encompass candidate selection, production of research materials, and both upstream and downstream process development. Additionally, Batavia Biosciences provides assay development, product characterization, and clinical manufacturing. By leveraging unique technologies such as STEP® protein expression technology and SCOUT® high throughput process technology, the company aims to enhance the efficiency and cost-effectiveness of the early stages of product development. This focus allows Batavia Biosciences to help clients complete their preclinical phases more quickly while improving the likelihood of success in transitioning to clinical trials.

Genocea Biosciences, Inc. is a biopharmaceutical company specializing in the discovery and development of innovative cancer immunotherapies and vaccines to address significant unmet medical needs. Based in Cambridge, Massachusetts, the company utilizes its proprietary ATLAS platform to profile patients' CD4+ and CD8+ T cell immune responses to identify potential targets within their tumors. Genocea's key programs include GEN-009, an adjuvanted neoantigen peptide vaccine currently in phase I/IIa clinical trials, GEN-011, a neoantigen adoptive T cell therapy, and GEN-010, a neoantigen vaccine initiative. The company also develops immunotherapies for other conditions, such as GEN-003, which targets genital herpes, and maintains pre-clinical programs focused on personalized cancer vaccines. Through its AnTigen Lead Acquisition System, Genocea is committed to advancing vaccine and immunotherapy solutions for various diseases.

TetraGenetics, Inc. is a biotechnology company focused on developing therapeutic proteins and vaccines for the biopharmaceutical industry. Established in 2004 and headquartered in Arlington, Massachusetts, the company utilizes its proprietary TetraExpress system to produce recombinant human ion channel proteins and other complex proteins. TetraGenetics offers products such as IchVax, a recombinant subunit vaccine aimed at preventing white-spot disease in freshwater fish. The company's platform leverages the protist Tetrahymena thermophila to efficiently generate properly folded, functional transmembrane proteins, which are often difficult to express using traditional methods. This technology supports the development of vaccine antigens, monoclonal antibodies, and therapeutic proteins for both human and animal health. Additionally, TetraGenetics has formed a strategic research and development collaboration with Imbrium Therapeutics L.P. to further enhance its offerings in the field of autoimmune diseases and pain management.

Genocea Biosciences, Inc. is a biopharmaceutical company specializing in the discovery and development of innovative cancer immunotherapies and vaccines to address significant unmet medical needs. Based in Cambridge, Massachusetts, the company utilizes its proprietary ATLAS platform to profile patients' CD4+ and CD8+ T cell immune responses to identify potential targets within their tumors. Genocea's key programs include GEN-009, an adjuvanted neoantigen peptide vaccine currently in phase I/IIa clinical trials, GEN-011, a neoantigen adoptive T cell therapy, and GEN-010, a neoantigen vaccine initiative. The company also develops immunotherapies for other conditions, such as GEN-003, which targets genital herpes, and maintains pre-clinical programs focused on personalized cancer vaccines. Through its AnTigen Lead Acquisition System, Genocea is committed to advancing vaccine and immunotherapy solutions for various diseases.

TetraGenetics, Inc. is a biotechnology company focused on developing therapeutic proteins and vaccines for the biopharmaceutical industry. Established in 2004 and headquartered in Arlington, Massachusetts, the company utilizes its proprietary TetraExpress system to produce recombinant human ion channel proteins and other complex proteins. TetraGenetics offers products such as IchVax, a recombinant subunit vaccine aimed at preventing white-spot disease in freshwater fish. The company's platform leverages the protist Tetrahymena thermophila to efficiently generate properly folded, functional transmembrane proteins, which are often difficult to express using traditional methods. This technology supports the development of vaccine antigens, monoclonal antibodies, and therapeutic proteins for both human and animal health. Additionally, TetraGenetics has formed a strategic research and development collaboration with Imbrium Therapeutics L.P. to further enhance its offerings in the field of autoimmune diseases and pain management.