Phytolon Ltd, located in Misgav, Israel, specializes in the development of technology for producing natural food colorants. Founded in 2000, the company utilizes baker's yeast cells as bio-factories to create these colorants through a fermentation process. Phytolon's innovative approach aims to provide sustainable and natural alternatives for the food and beverage industry, addressing the growing demand for clean-label products.
SetBone Medical develops a new bone cement for the treatment of VCF and primarily caused by osteoporosis.
FruitSpec Ltd. designs and manufactures hyperspectral sensor system for fruit yield estimation. The company provides FruitSpec sensor pods that scan and analyze the trees. It also offer FruitSpec, a software solution that connected with sensor system that enables to count the number of fruits, estimate fruit sizes, and estimate fruit yield. It serves farmers, distributors, and insurance companies. FruitSpec Ltd. was founded in 2016 and is based in Tel Aviv, Israel.
Currently, after surgical removal of tumors found in the bladder, a drug is instilled into the bladder via a catheter. This treatment method is inefficient and ineffective: Urinary bladder cancer has the highest recurrence rates among all types of cancer (70%). Using Vensica’s device, the drug will be instilled in a quick, pain-free procedure subsequent to the delivery of ultrasound to the urinary bladder. Ultrasound improves the uptake of the drug and its penetration into the bladder wall and is expected to improve the treatment and reduce recurrence rates.
Fidmi Medical is an Israeli start-up company founded in 2014 that is dedicated to developing enhanced feeding devices that offer easy insertion, replacement, and removal.
CoreBone has developed a highly bioactive, 100% mineral, strong bone graft material for dental, orthopedic and spine applications. The patented technology embeds bioactive minerals (e.g., silicium) into the skeleton of corals during their growth process, accelerating healing and providing better bone connectivity. CoreBone was founded by CEO Ohad Schwartz and CTO Prof. Itzhak Binederman. It is one of the portfolio companies of The Trendlines Group. CoreBone has issued patents and substantial know-how in regard to growing coral for medical purposes.
AgroScout Ltd. is an agricultural technology company based in Misgav, Israel, founded in 2017. It specializes in developing an artificial intelligence-based system for the rapid detection and monitoring of crop diseases across entire fields. The AgroScout platform integrates data from various sensors, including weather, satellite, and local sources, along with machine learning and deep learning algorithms. This technology allows for accurate identification of diseases and pests, providing farmers with actionable insights delivered via cloud-based access on computers and mobile devices. The system not only enhances disease management but also supports sustainable farming practices by improving crop yields and reducing pesticide use. Through its innovative approach, AgroScout empowers farmers with better decision-making tools to optimize crop health and productivity.
Equinom is a seed-breeding technology company dedicated to creating superior food ingredients through precision breeding methods. By leveraging DNA sequencing, big data processing, and proprietary algorithms, Equinom enhances the nutritional profiles of grains and develops new varieties that exemplify natural quality. This innovative approach makes their breeding process significantly more accurate than traditional techniques and reduces the time required to bring products to market. Equinom targets two primary areas: sesame and legumes. In sesame, the company has developed high-yield, mechanically harvestable varieties that have transformed the market. In legumes, Equinom focuses on creating varieties with protein levels 40% higher than currently available options, addressing the increasing global demand for sustainable protein sources. By partnering with stakeholders across the food ingredients supply chain, Equinom aims to deliver tailored crop varieties that support sustainable development in the food industry while providing substantial economic benefits.
IBI-Ag is a biotechnology company developing a new class of bioinsecticides. IBI-Ag is focused on the discovery and development of new types of biological solutions that utilize environmentally friendly technology to control insects. IBI-Ag utilizes breakthrough technology to produce efficient, selective, and safe bio-insect control solutions. IBI-Ag technology is highly cost-effective due to its fermentation suitability enabling farmers to produce agricultural produce at a low cost.
ViAqua Therapeutics Ltd develops drugs and therapeutics for aquaculture. The company was founded in 2014 and is based in Israel.ViAqua Therapeutics is developing the first orally administered treatment for aquaculture.The Company’s management bring a broad range of business development, technology development, management, and industrial biotech experience.
The ZygoFix is a medical device company.
Limaca Medical is developing a game-changer in endoscopic ultrasound-guided biopsy for Precision Medicine.
Phytolon Ltd, located in Misgav, Israel, specializes in the development of technology for producing natural food colorants. Founded in 2000, the company utilizes baker's yeast cells as bio-factories to create these colorants through a fermentation process. Phytolon's innovative approach aims to provide sustainable and natural alternatives for the food and beverage industry, addressing the growing demand for clean-label products.
Vessi Medical, an Israeli medical device startup, brings a new approach to treat Non-Muscle-Invasive Bladder Cancer (NMIBC). Vessi uses surface cryotherapy, a treatment that utilizes extreme cold, to freeze and destroy abnormal tissue. Categorized as surface cancer on the inside lining of the bladder, NMIBC affects 2 million people globally with 300,000 new cases reported every year. TransUrethral Resection of Bladder Tumor (TURBT) is the leading first-line therapy. Yet, this invasive surgical procedure, requiring a costly hospital stay performed under general anesthesia, can often be inadequate. In up to 80% of cases the cancer returns, with increased complications as patients need multiple repeat procedures that further reduce quality of life. Vessi's minimally invasive NMIBC solution provides a new, first-line, office-based therapy alternative to surgery. The company's patent-pending, bladder-specific cryotherapy technology eliminates costly and problematic repeat surgeries seen with TURBT, reducing the need for hospital stay by providing in office or ambulatory treatment. The technology successfully ablates unwanted tissue, reduces the risk of dispersed cancers cells, all while causing no bladder damage. The Vessi system consists of a standalone console and a disposable catheter that is inserted into the bladder. Vessi is backed by the Trendlines Group, a leading Israeli early stage investor, and led by seasoned medical device and cryotherapy veterans. The company has already demonstrated promising proof of concept in animals with its Alpha product. Vessi’s first application will initially target the $1.2 billion NMIBC market, with future applications for the treatment of overactive bladder and urinary tract infections, both billion-dollar markets.
Saturas Ltd. develops and manufactures SWP sensor-based irrigation sensor systems for farmers to provide an accurate indication of water status in crops. Its embedding sensors in the trunk provide direct contact with water tissues for accurate and continuous water status measurement. The company’s agriculture sensing system includes miniature implanted sensors, wireless transponders, and delivery of information to the farmer’s Internet device (computer, tablet, or smartphone). Saturas Ltd. was founded in 2013 and is based in Misgav, Israel.
AgroScout Ltd. is an agricultural technology company based in Misgav, Israel, founded in 2017. It specializes in developing an artificial intelligence-based system for the rapid detection and monitoring of crop diseases across entire fields. The AgroScout platform integrates data from various sensors, including weather, satellite, and local sources, along with machine learning and deep learning algorithms. This technology allows for accurate identification of diseases and pests, providing farmers with actionable insights delivered via cloud-based access on computers and mobile devices. The system not only enhances disease management but also supports sustainable farming practices by improving crop yields and reducing pesticide use. Through its innovative approach, AgroScout empowers farmers with better decision-making tools to optimize crop health and productivity.
OrthoSpin is developing innovative robotic external fixation system that will improve patient treatment and allow a real-time review to reduce complications and improve clinical outcomes. Dynamic external fixators are mainly used for trauma, bone lengthening and congenital deformities correction. Those systems are cumbersome, painful and require high maintenance.
With OrthoSpin’s smart system, physicians are assured that the prescribed course of treatment is being followed. The Company’s proprietary software program allows physicians to chart patient progress and, if required, to easily change the treatment schedule.
AlgaHealth specializes in the development of microalgal sources for high-quality fucoxanthin, a compound utilized in health and cosmetics. The company employs a novel microalgae cultivation algorithm that enhances efficiency by 15% to 50% and has established processing protocols to produce large quantities of natural fucoxanthin at a significantly reduced cost. In addition to fucoxanthin, AlgaHealth also aims to produce polysaccharides as a valuable by-product, contributing to a diverse range of high-value microalgal products. This innovative approach to growing microalgae inland and the use of unique microalgal strains positions AlgaHealth to meet the increasing market demand for quality additives in health supplements and skincare, while promoting sustainable biotechnology practices.
Equinom is a seed-breeding technology company dedicated to creating superior food ingredients through precision breeding methods. By leveraging DNA sequencing, big data processing, and proprietary algorithms, Equinom enhances the nutritional profiles of grains and develops new varieties that exemplify natural quality. This innovative approach makes their breeding process significantly more accurate than traditional techniques and reduces the time required to bring products to market. Equinom targets two primary areas: sesame and legumes. In sesame, the company has developed high-yield, mechanically harvestable varieties that have transformed the market. In legumes, Equinom focuses on creating varieties with protein levels 40% higher than currently available options, addressing the increasing global demand for sustainable protein sources. By partnering with stakeholders across the food ingredients supply chain, Equinom aims to deliver tailored crop varieties that support sustainable development in the food industry while providing substantial economic benefits.
AquiNovo is focused on addressing the expanding aquaculture industry, which is facing challenges due to the depletion of marine resources and rising fish consumption. The company develops feed additives that accelerate fish growth through a platform of non-genetically modified, non-hormonal peptides. These additives improve gut performance and health in fish, leading to higher production yields. Additionally, the technology has potential applications in treating gastrointestinal conditions in both production and companion animals. By providing sustainable solutions, AquiNovo aims to enhance fish farming practices and help meet the increasing global demand for fish protein.
BioFishency is developing a cost-effective, all-in-one water treatment system for land-based aquaculture. The system operates with all different aquaculture methods: extensive (land ponds), intensive (constructed ponds), and recirculated. It enables fish farms to double or triple production while continuing to use installed infrastructure.
BioFishency overcomes the two key aquaculture challenges: limited water availability and buildup of toxic ammonia (excreted by the fish). It enhances the water conditions to increase the ability of the fish to survive, grow, and reproduce. With BioFishency’s system, farmers increase fish production with minimal investment, significantly increasing profitability and sustainability.
Saturas Ltd. develops and manufactures SWP sensor-based irrigation sensor systems for farmers to provide an accurate indication of water status in crops. Its embedding sensors in the trunk provide direct contact with water tissues for accurate and continuous water status measurement. The company’s agriculture sensing system includes miniature implanted sensors, wireless transponders, and delivery of information to the farmer’s Internet device (computer, tablet, or smartphone). Saturas Ltd. was founded in 2013 and is based in Misgav, Israel.
AlgaHealth specializes in the development of microalgal sources for high-quality fucoxanthin, a compound utilized in health and cosmetics. The company employs a novel microalgae cultivation algorithm that enhances efficiency by 15% to 50% and has established processing protocols to produce large quantities of natural fucoxanthin at a significantly reduced cost. In addition to fucoxanthin, AlgaHealth also aims to produce polysaccharides as a valuable by-product, contributing to a diverse range of high-value microalgal products. This innovative approach to growing microalgae inland and the use of unique microalgal strains positions AlgaHealth to meet the increasing market demand for quality additives in health supplements and skincare, while promoting sustainable biotechnology practices.
ElastiMed Ltd. develops innovative medical devices focused on compression therapy, specifically addressing conditions like Chronic Venous Insufficiency and Deep Venous Thrombosis. Founded in 2015 and based in M.P. Misgav, Israel, the company has created a wearable, smart compression device designed to enhance circulation in the legs. Utilizing proprietary technology and advanced smart materials, ElastiMed's device functions as a sock that compresses and massages the legs when stimulated by an electric pulse. This product aims to provide patients with a comfortable, effective, and affordable treatment option to alleviate symptoms such as swelling, blood clots, and leg ulcers.
FruitSpec Ltd. designs and manufactures hyperspectral sensor system for fruit yield estimation. The company provides FruitSpec sensor pods that scan and analyze the trees. It also offer FruitSpec, a software solution that connected with sensor system that enables to count the number of fruits, estimate fruit sizes, and estimate fruit yield. It serves farmers, distributors, and insurance companies. FruitSpec Ltd. was founded in 2016 and is based in Tel Aviv, Israel.
Gordian Surgical was founded at the end of 2012 and operates within the framework of the Misgav Venture Accelerator, part of The Trendlines Group.
The company has three U.S. patents that cover the laparoscopic trocar and fascial closure systems and methods and suture anchor deployment systems and methods. Gordian has developed an initial prototype and will start preclinical trials in mid-2013.
EdenShield Ltd. is an Israel-based AgTech company founded in 2012, specializing in the development of nontoxic insect control products for greenhouse crops. The company offers a range of organic and chemical-free solutions, including EdenNet, EdenDirect, and EdenForte, which are formulated from botanical extracts and nutrients derived from native Israeli semi-desert plants. These products utilize proprietary aromatic ingredients that mask plant odors and reduce insect attraction, effectively preventing pest-related damage and the spread of viruses. EdenShield's innovative approach helps growers enhance the yield and health of crops, including cannabis, vegetables, and flowers, while promoting environmentally friendly agricultural practices.
MetoMotion is developing a multipurpose robotic system, GRoW, for labor-intensive tasks in greenhouses to reduce the reliance on and high costs of human labor in greenhouse vegetable production. The Company’s first application is greenhouse tomatoes.
Hargol™ FoodTech is the world's first commercial grasshopper farm! Grasshoppers are nature's most efficient protein source. Hargol™ FoodTech revolutionize the protein ingredient industry by providing a healthier and more sustainable and affordable alternative, becoming the leading intensive rearing company of grasshoppers in the world. The company is at the forefront of high quality nutrients and healthy grasshoppers supply to markets around the world, improving current market wild-harvested supply by providing year-round availability, nutrients content & quality and costs reduction. For its first line of products, Hargol FoodTech relies on methods and technologies of intensive breeding and growing of three grasshopper species that are processed into protein powders. The company is offering grasshopper based protein ingredient in North America markets to food/ingredient manufacturers and whole grasshoppers. Hargol™ FoodTech have thus far been attracting the interest of food producers, distributors and retailers in the North America, Europe and other regions of the world with whole grasshoppers, grasshopper’s nutrient-rich powder and innovative food products. With the expected 70% rise in demand for animal source protein over the next decades and with existing animal source protein taking a big toll on the environment there is a need for an alternative – Both sustainable and affordable for populations around the globe. Enhanced by their vegetarian diet grasshoppers’ nutrient content is superior compare to other insects or animal source protein: Over 70% whole protein, Omega-3 & Omega-6, Zinc, Iron, & Folic acid. Grasshoppers are also the only Kosher and Halal insect in the world!
Saturas Ltd. develops and manufactures SWP sensor-based irrigation sensor systems for farmers to provide an accurate indication of water status in crops. Its embedding sensors in the trunk provide direct contact with water tissues for accurate and continuous water status measurement. The company’s agriculture sensing system includes miniature implanted sensors, wireless transponders, and delivery of information to the farmer’s Internet device (computer, tablet, or smartphone). Saturas Ltd. was founded in 2013 and is based in Misgav, Israel.
EdenShield Ltd. is an Israel-based AgTech company founded in 2012, specializing in the development of nontoxic insect control products for greenhouse crops. The company offers a range of organic and chemical-free solutions, including EdenNet, EdenDirect, and EdenForte, which are formulated from botanical extracts and nutrients derived from native Israeli semi-desert plants. These products utilize proprietary aromatic ingredients that mask plant odors and reduce insect attraction, effectively preventing pest-related damage and the spread of viruses. EdenShield's innovative approach helps growers enhance the yield and health of crops, including cannabis, vegetables, and flowers, while promoting environmentally friendly agricultural practices.
Catalyst AgTech Ltd. develops technology for the agriculture sector. The company develops a customizable technology with a self-destruction mechanism for use in persistent pesticides, herbicides, and fungicides. Its technology platform helps in preventing agrochemical contamination. Catalyst AgTech Ltd. is based in Misgav, Israel.
Valentis Nanotech, founded in 2013 and part of Trendlines Agtech, specializes in the development of polymeric films, coatings, and compounds. The company has patented a technology that utilizes cellulose nanocrystals combined with nanoparticles to create biodegradable, transparent films derived from plant pulp waste. These films exhibit enhanced strength, improved spectral control, and effective barriers against UV rays, oxygen, and moisture. Valentis collaborates with a leading agricultural thermoplastics company in Israel to advance product development, enabling the creation of tailored materials suitable for various applications across multiple industries. The innovative approach of Valentis positions it as a key player in the field of sustainable materials.
LapSpace Medical Ltd. is a company based in Misgav, Israel, that specializes in the development of medical devices for laparoscopic surgery. Founded in 2011, it operates under the Misgav Venture Accelerator, which is part of The Trendines Group. The team at LapSpace Medical brings together a blend of business acumen and medical expertise to create innovative solutions aimed at enhancing surgical procedures.
ApiFix Ltd. is focused on developing a minimally invasive scoliosis deformity correction system specifically designed for adolescents suffering from Adolescent Idiopathic Scoliosis (AIS). Targeting patients categorized as Lenke Type 1 or Type 5 with a Cobb angle between 35 and 55 degrees, ApiFix's innovative approach differs from traditional scoliosis surgeries by allowing for gradual correction over several months, rather than a single invasive procedure. This system utilizes a miniature ratchet mechanism to facilitate incremental adjustments as the patient bends in the corrective direction, combined with specialized physical therapy to enhance outcomes. Founded in 2011 and based in Misgav, Israel, ApiFix operates as a subsidiary of OrthoPediatrics Corp. since April 2020.
MitrAssist introduces a minimally invasive approach to MR treatment. Its mitral valve implant works in unison with the natural mitral valve without harming its functionality. MitrAssist has developed a new approach to treating MR that is neither repair nor replacement. Instead, its proprietary valve implant is placed on top of the natural valve to work in unison with it and to enhance valve functionality. MitrAssist’s “valve-in-valve” approach overcomes the various challenges of MR and offers an improved treatment solution for all MR patients. It has significant advantages over minimally invasive solutions – both existing and in development.
Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy products aimed at treating cancer and infectious diseases in adult patients. The company specializes in therapies that utilize living immune cells as active components. Its notable products include AlloStim, which features activated T-Stim cells for infusion; CryoVax, an in-situ therapeutic cancer vaccine targeting metastatic tumors; CRCL, a source of patient-specific tumor antigens; and AlloVax, a personalized anti-cancer vaccine designed to educate the immune system during cancer remission. Immunovative Therapies addresses various indications, including hematological malignancies, prostate cancer, breast cancer, glioblastoma, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. Established in 2004, the company has received financial support from the Israel Office of the Chief Scientist and is recognized as a graduate of the Misgav Venture Accelerator program.
InnoLap Surgical
Venture Round in 2012
InnoLap Surgical develops a device for scarless laparoscopic procedures. The device comprises a handle, thin 3 mm needle, and 5-10 mm detachable and replaceable operating heads. The company was founded in 2012 and is based in Misgav, Israel. As of September 30, 2013, InnoLap Surgical Ltd. operates as a subsidiary of Teleflex Incorporated.
Polytouch Medical focuses on advancing minimally invasive surgery by developing innovative solutions for laparoscopic procedures, particularly in hernia repair. The company specializes in hernia mesh placement technologies, with its flagship product, PatchAssist, designed to enhance the deployment and positioning of mesh during surgery. This technology primarily targets ventral hernias, enabling patients to initiate treatment more swiftly and improving the chances of successful outcomes. Polytouch Medical collaborates closely with physicians to ensure that their products effectively address clinical needs, while a dedicated team of employees and medical advisors work together to transform innovative ideas into practical solutions.
Nephera (Israeli) a development-stage medical device company focused on kidney function in CHF patients. Nephera offers a treatment for acute heart failure patients by protecting kidney function through the modulation of sympathetic nerve activity. The company’s unique technology, in the exciting field of neurohormonal modulation, is based on electrical stimulation of the urinary tract for controlled inhibition of renal sympathetic nerve activity. The clinical outcome is preserved renal function and enhanced diuretic therapy.
Inspiro Medical Ltd. is a medical device company dedicated to the development of a global inhalation platform designed to deliver both small molecules such as corticosteroids or beta agonists; and macromolecules such as antibodies or vaccines. The Company is currently performing clinical trials with asthmatic children using Inspiromatic, its proprietary dry powder inhaler.
Stimatix GI is an early stage startup company founded in June 2009. The Company operates under the auspices of the Misgav Venture Accelerator, and is jointly funded by the Office of the Chief Scientist and the Misgav Venture Accelerator. Stimatix GI has developed the Artificial Ostomy Sphincter (AOS) product line with its AOS-1000™ and AOS-C2000™ products, unique colostomy devices that provide voluntary bowel evacuation. Aesthetically designed and easy to use, the AOS products seal the stoma and eliminate the problems inherent in wearing traditional adhesive bags. These proprietary low- profile colostomy appliances allow people with stoma to decide, at their convenience, when and where to evacuate. With the AOS products, evacuation routine is easier, quicker, and cleaner than ever. And, as the stoma is hermetically sealed, skin irritation and folliculitis are eliminated.
The URINFO 2000 fluid monitoring system is the only feasible solution for the accurate, real-time, and continuous monitoring of urine output. The product is based on FlowSense’s patented optical flow sensing technology. URINFO2000 has been used in the critical care setting to optimize fluid and electrolyte balance, treat acute kidney injury, and prevent renal failure.
ETView Medical Ltd. specializes in innovative airway management solutions by integrating continuous direct airway visualization into its products. The company manufactures single-use endotracheal tubes, both single and double-lumen, which are equipped with a high-resolution video imaging system. This technology is particularly beneficial for medical professionals dealing with challenging intubation scenarios, as it enhances visibility and control during procedures. ETView's product line includes various imaging systems, such as the VivaSight SL and DL, designed to improve patient safety and outcomes in airway management.
VivoText is a creative digital speech platform for entertainment and media. VivoText's platform is for the creative crafting of expressive speech with virtual human voices. VivoText's virtual voices offer scalability, interactivity and personalization which are not possible with pre-recorded content, and preserves the need of authors to maintain creative control over the expression and emotion of the speech output. It empowers content creators to fully engage in the speech creation process in order to achieve the expression and emotion that reflect their sensibilities and preferences. VivoText's target industries are publishing, gaming, marketing, and others where personalization and scalability are paramount.
LifeBond Ltd. specializes in the development and manufacturing of absorbable bio-surgical medical devices aimed at enhancing tissue repair and improving patient recovery. Founded in 2006 and based in Caesarea, Israel, the company offers innovative products such as LifeSeal, a surgical sealant designed to reinforce staple lines in bariatric and colorectal surgeries, thereby minimizing complications like leakage. Another key product is LifeMesh, a self-fixating mesh intended for hernia repair, which is currently in pre-clinical development. LifeBond’s portfolio also includes tissue adhesives and absorbable hemostats. The company's devices are designed to meet various surgical needs, leveraging their natural origin, elasticity, adhesiveness, and durability. LifeBond's products are available in multiple regions, including China, the United States, and Europe, although they are still under investigation and have not received market approval.
BioSight Ltd. is a biopharmaceutical company focused on the development of innovative cancer-targeted chemotherapy pro-drugs. Founded in 1999 and based in Lod, Israel, BioSight specializes in creating treatments that minimize systemic toxicity while effectively delivering chemotherapy directly to cancer cells. One of its notable products is a non-toxic conjugate of cytarabine and asparagine designed for treating acute myeloid leukemia. The company's proprietary technology, S2DOT, supports its pipeline of targeted pro-drugs, aiming to revolutionize cancer treatment by enhancing efficacy and reducing side effects associated with traditional chemotherapy. Since its relaunch in 2009, BioSight has pursued advancements in the research and development of these targeted therapies.
Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy products aimed at treating cancer and infectious diseases in adult patients. The company specializes in therapies that utilize living immune cells as active components. Its notable products include AlloStim, which features activated T-Stim cells for infusion; CryoVax, an in-situ therapeutic cancer vaccine targeting metastatic tumors; CRCL, a source of patient-specific tumor antigens; and AlloVax, a personalized anti-cancer vaccine designed to educate the immune system during cancer remission. Immunovative Therapies addresses various indications, including hematological malignancies, prostate cancer, breast cancer, glioblastoma, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. Established in 2004, the company has received financial support from the Israel Office of the Chief Scientist and is recognized as a graduate of the Misgav Venture Accelerator program.