Founded in 2015, Underscore.VC is a Boston-based venture capital firm focusing on seed to series A investments. It primarily invests in technology companies with an emphasis on sensor-related technologies, software for factories and home automation, healthcare infrastructure, data storage databases, and cloud-based marketing/commerce software.

Insight Partners is a global software investor that partners with growth-stage technology and software companies. The firm focuses on growth-stage software, internet, and data services, with emphasis on fintech, cybersecurity, artificial intelligence and machine learning, DevOps, and healthcare. Based in New York City with offices in London, Tel Aviv, and Palo Alto, Insight Partners has backed more than 750 companies worldwide and has more than 55 portfolio companies that have achieved an IPO. As of 2022, the firm reports over $75 billion in assets under management. It seeks to fund and work closely with visionary executives, providing practical, hands-on software expertise to support growth from initial investment through to IPO.

MassVentures is a venture capital firm based in Waltham, Massachusetts, established in 1978 as a quasi-public corporation by the Massachusetts Legislature. The firm focuses on providing seed and early-stage funding to high-growth startups, facilitating their transition from concept to commercialization. MassVentures invests primarily in sectors such as information technology, healthcare, cybersecurity, e-commerce, mobile, manufacturing, and robotics. With a governance structure that includes an independent Board of Directors and management by experienced venture capitalists, MassVentures leverages the state's entrepreneurial spirit and innovation centers to support the Massachusetts innovation economy. The firm also offers accelerator programs to further assist emerging companies in their growth journey.

WindSail Capital Group, LLC is a private equity and venture capital firm based in Boston, Massachusetts, established in 2013. The firm specializes in providing growth capital to companies focused on energy innovation and sustainability across various industries. WindSail offers a range of financing solutions, including senior secured loans, junior secured loans, stretch loans, and bridge loans, primarily targeting U.S.-based businesses. With an investment strategy that emphasizes flexible financing options, WindSail aims to support companies that are either revenue-generating or in the early stages of commercial development. The firm typically invests equity ranging from $2 million to $8 million and debt from $2 million to $10 million, ensuring its portfolio companies have the necessary resources to facilitate growth while minimizing equity dilution.

Samsung Venture Investment Corporation is the corporate venture arm of Samsung Electronics, founded in 1999 and based in Seoul. It maintains a global presence with activity in innovation hubs such as the San Francisco Bay Area, Boston, London, Tel Aviv, Bangalore, Tokyo, and Beijing, and it backs emerging technology startups across Europe, Asia, and North America. The firm sources and invests in technology companies at multiple stages, from early-stage to pre-IPO, focusing on areas including semiconductors, materials, mobile services, internet, software, security, and enterprise solutions, as well as bioengineering and medical tech. Its investment approach targets companies developing AI, robotics, augmented and virtual reality, cybersecurity, 5G, next generation displays, battery technology, digital health, and insurtech, among others, to support shaping future technologies.

Avalon Ventures is a venture capital firm established in 1983 with operations in San Diego and Boston. The firm concentrates on seed and early-stage investments in technology and life sciences companies across the United States. It supports founders pursuing disruptive ideas in rapidly changing markets and seeks opportunities in information technology, software, telecommunications, and biopharma areas. Avalon often collaborates with other investors to expand opportunities and provides strategic guidance during the critical development phase of portfolio companies. The firm emphasizes a hands-on approach, leveraging its entrepreneurs-turned-investors background to help early ventures navigate product, market, and regulatory challenges.

Omega Funds is a Boston-based venture capital and private equity firm founded in 2004 that concentrates on early-stage investments in healthcare and biotech across North America and Western Europe, backing companies in life sciences, digital health, immunology, rare diseases, precision medicine, oncology, cybersecurity, and software-as-a-service.

Founded in Boston in 2004, RA Capital is an investment firm specializing in life sciences and drug development. Its team, with backgrounds in biology, chemistry, medicine, and industry experience, invests in early-stage companies with promising technologies and products across healthcare and life science sectors.

Founded in Toronto in 2007, Lumira Ventures is a venture capital firm focusing on investments in biotechnology, biopharmaceuticals, medical devices, digital health, and consumer health companies. With offices across North America, the firm invests primarily in Canada and the United States, typically allocating between USD 5 million to USD 15 million per investment. Lumira Ventures actively supports its portfolio companies by facilitating access to funding sources, partners, and market opportunities.

Boston Seed Capital is a seed- and early-stage venture capital firm based in Massachusetts, with offices in Boston and Wellesley Hills. Founded in 2010, it focuses on funding internet-enabled and technology-driven startups across the United States, including consumer products, B2B software as a service, cybersecurity, e-commerce, big data, artificial intelligence and machine learning, marketplaces, and related services. The firm backs early-stage companies, often in information technology and SaaS, providing capital and strategic support to help companies scale from initial traction to growth.

Battery Ventures is a technology-focused investment firm founded in 1983 and based in Boston, Massachusetts. It engages in venture capital and private equity investments in technology companies, with emphasis on software (including application and infrastructure software), IT infrastructure technologies, consumer internet and mobile services, industrial technologies, and life science tools. The firm seeks to back category-defining businesses with potential for scalable growth, often supporting companies through multiple stages and across select global regions.

Accomplice is a Boston-based venture capital firm, with an additional office in San Francisco, specializing in seed and early-stage investments in technology startups. It primarily invests in companies focused on cybersecurity, eSports, data analytics, SMB class software, emerging hardware platforms, and marketplaces. Accomplice uniquely leverages community platforms like AngelList, Boston Syndicates, and Maiden Lane to empower and fund exceptional founders. With a majority of its investments in Boston and additional investments throughout the U.S., Canada, and the E.U., Accomplice is one of the most active early-stage firms in New England.

Boston-based venture capital firm founded in 2005 that focuses on early-stage and select growth investments in information technology and related services. The firm backs enterprise IT companies, emphasizing information security, cloud infrastructure, data analytics, and software-as-a-service models, as well as technology-enabled business services and digital health, and it also targets healthcare IT, fintech, mobile software, and next-generation software. It prefers open source and SaaS delivery. Typically investing initial rounds of 2 to 5 million and totaling 6 to 10 million per company, it seeks board representation and often serves as lead or first institutional investor, with minority to majority stakes ranging from 20 to 80 percent. The firm reserves capital for opportunistic investments in more mature companies where its team has prior experience and focuses on opportunities in the Northeast United States.

Matrix Partners is a venture capital firm founded in 1977 and based in San Francisco that backs early-stage and Series A technology companies across sectors such as artificial intelligence, B2B software, consumer technology, fintech, health tech, infrastructure, and semiconductors. The firm emphasizes practical, founder-centered collaboration, often supporting concepts from idea stage through Series A and taking board seats to help portfolio companies scale. It operates globally, including Matrix Partners China, which focuses on long-term relationships with entrepreneurs in China and has a track record of IPOs and strategic exits. The team combines former founders and experienced investors to bring local execution and global perspective. Notable investments span across the technology landscape, reflecting a history of involvement with companies like FedEx, Apple, Oculus, Canva, Zendesk, HubSpot, Postmates, Fivetran, Sila, and GOAT, illustrating the firm’s ability to support companies from early development to scale.

Silversmith Capital Partners is a Boston-based growth equity firm founded in 2015 that partners with technology and healthcare companies to support growth and profitability. It targets investments in software, information technology and services, healthcare information technology and services, and other technology-enabled healthcare businesses, providing growth capital and strategic guidance to help companies scale, innovate, and expand market reach.

Romulus Capital, established in 2008, is a Boston-based venture capital firm that specializes in seed and early-stage investments, primarily in technology startups across the United States, with a focus on the East Coast, and select opportunities in London, Israel, and India. The firm invests in a broad range of sectors, including software, big data, healthcare IT, education, and energy technology, with a preference for B2B and B2B2C models. Romulus Capital typically invests between $100,000 and $1 million initially, with the ability to scale up to $5 million over time as companies grow. The firm is known for its company-building approach, partnering with brilliant, often first-time entrepreneurs frequently affiliated with top universities and incubators.

Founded in 2013, Bolt is a venture capital firm based in Boston, Massachusetts. It specializes in seed and early-stage investments in technology and data-driven sectors.

Tiger Global Management is a New York based investment firm that manages public and private market strategies to pursue technology-driven growth opportunities worldwide. Founded in 2001 by Charles (Chase) Coleman, the firm invests in leading global companies across various industries, with a particular emphasis on technology-enabled growth. In public markets it employs long/short and growth strategies, while in private markets it targets opportunities from early to late stage. The firm operates globally, including the United States, China, India, Latin America, and Eastern Europe, and works with portfolio companies across their lifecycle to drive long-term value.

LRVHealth is a Boston-based venture capital firm founded in 2000 with additional offices in Marlborough and Amherst, Massachusetts. It concentrates on technology and healthcare investments across seed, early, and growth stages, including Series A and Series B rounds. The firm backs software, software-as-a-service, digital health, healthcare information technology, technology-enabled services, medical devices, diagnostics, and biotechnology, typically investing between $0.5 million and $5 million and often pursuing co-investments. While it seeks opportunities in the United States, it has a regional emphasis on Massachusetts. LRVHealth combines capital with operating experience and industry insight to help portfolio companies grow. It positions itself as an Inside Healthcare network, linking providers, payers, and vendors to identify and adopt innovative solutions addressing the industry's needs. Exits are commonly achieved through trade sales. The firm seeks to support early healthcare and tech-enabled companies by providing strategic guidance, market access, and operational support alongside capital.

Founded in 2018, EduLab Capital Partners is a Boston-based venture capital firm focused on seed-stage investments in the education market. The firm invests in innovative business models that transcend traditional education landscapes and provides foundational support to entrepreneurs for customer base expansion, early-stage hiring, and raising additional capital.

Founded in 1989, OrbiMed is a New York-based healthcare-dedicated investment firm managing approximately $5 billion in assets. It invests across the spectrum of healthcare companies, from private start-ups to large multinational corporations, focusing on biopharmaceuticals, life sciences, digital health, medical devices, and diagnostics sectors globally.

Founded in 1973, Abingworth is an international investment group dedicated to collaborating with life sciences entrepreneurs. With over $1 billion under management, it invests across all stages of development and sectors within the life sciences industry. The company supports its portfolio companies with a team of 27 based in London, Menlo Park, and Boston.

Logos Capital is a hedge fund manager based in San Francisco, founded in 2019, specializing in fundamental biotechnology investments. The firm combines in-house data analytics with scientific and clinical expertise to rigorously evaluate potential therapies and treatment platforms. It uses fundamental and sector-focused equity strategies and applies statistical modeling of clinical data to strengthen diligence and identify compelling opportunities with the aim of delivering uncorrelated returns. By integrating medical, scientific, and statistical perspectives, Logos Capital seeks to deepen its conviction in investment ideas and maintain disciplined risk management.

Morningside is a venture capital firm based in the greater Boston area, specializing in investments in companies that focus on innovative science and technology. Established in 1986 as a family office for the Chan family, Morningside emphasizes a long-term approach to company-building and maintains a strong commitment to ethical practices. The firm is staffed by a team of experienced investment professionals with expertise in various sectors, including life sciences, digital health, artificial intelligence, materials, and technology. In addition to its investment activities, Morningside is dedicated to philanthropic efforts, supporting education, research, and healthcare initiatives such as the Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.

Kodiak Venture Partners is a venture capital firm that specializes in seed and early-stage investments, primarily in emerging technology sectors. The firm focuses on communications and wireless, semiconductor and equipment, software and services, Internet and new media, and life technology companies. Kodiak Venture Partners is based in Boston, Massachusetts, and primarily invests in Eastern North America, with particular attention to Boston, New York, and Eastern Canada. The firm typically makes investments ranging from $100,000 to $3 million and emphasizes building strong relationships with entrepreneurs to help develop business strategies, management teams, and essential alliances. Founded in 1999, Kodiak Venture Partners has a reputation for fostering high-growth industry leaders through a hands-on investment approach.

Founded in 2010, BOLDstart Ventures is a venture capital firm based in Miami, Florida. It focuses on investing in early-stage technology companies, particularly those working on enterprise infrastructure and SaaS. The firm often partners with technical founders from the inception stage, providing lead investment and support to help them achieve product-market fit.

186 Ventures is an early-stage technology investor and venture capital firm based in Boston, Massachusetts. Founded in 2018, it backs agile teams solving disruptive problems and Invests across consumer, enterprise, and technology sectors.

Established in 2011 and headquartered in Boston, Gutbrain Ventures is an independent venture capital firm specializing in investments within the enterprise software sector.

Founded in 2015, Sapir Venture Partners is a venture capital firm based in Jerusalem, Israel. It focuses on pre-seed stage investments in biotech and deep-technology sectors, providing mentorship to founders leveraging cutting-edge science for positive impact.

TA Ventures is a global venture capital firm that backs early-stage technology startups and select growth-stage opportunities. It writes initial equity checks and provides follow-on investment capacity to help portfolio companies scale, focusing on sectors including digital health, mobility and logistics, fintech, consumer tech, and enterprise software, as well as AI-enabled applications. The firm emphasizes swift execution and active support, leveraging its international network to connect portfolio companies with high-quality co-investors and to access cost-efficient R&D talent. Headquartered in Kyiv, TA Ventures operates across Europe, North America and other regions with additional offices in Frankfurt, Boston, Zurich, Grand Cayman, Nicosia and elsewhere, reflecting a global footprint. The firm shows a preference for opportunities in Ukraine and Israel, and aims to help Western market entrants in local ecosystems through collaboration, while typically avoiding board seats in some investments.

Founded in 2012, Fraser McCombs Capital is a venture capital firm headquartered in Boulder, Colorado. It specializes in early to mid-stage investments, focusing primarily on innovative automotive technology and niche mobile technologies within specific verticals.

Walnut Ventures is a venture capital firm headquartered in Boston, Massachusetts, that focuses on investing in seed and early-stage companies, primarily within the information technology sector. The firm is particularly interested in areas such as home entertainment software, data processing, online services, and internet marketing. It typically invests between $250,000 and $1 million in companies located in the New England region and aims to take an active role by seeking a board seat in its portfolio companies. Established in 1997, Walnut Ventures comprises a network of experienced entrepreneurs and investors who are dedicated to helping talented entrepreneurs build sustainable businesses in rapidly growing markets. The firm offers not only financial investment but also support in refining business plans, enhancing management teams, developing financing strategies, and facilitating strategic partnerships.

Headquartered in San Francisco with offices globally, Citi Ventures explores, incubates, and invests in innovative ideas across fintech, data analytics, commerce, security, marketing, property tech, distributed ledger technology, and digital assets. It collaborates with Citi colleagues, clients, and the broader innovation community to drive discovery of new value.

IA Ventures, established in 2010, is a New York-based venture capital firm focusing on seed and early-stage investments. It specializes in financial services, fintech, fraud detection, healthcare, and data privacy sectors, with a particular interest in companies utilizing machine learning, predictive analytics, and data-driven technologies. The firm invests in the U.S. East Coast, Israel, and the United Kingdom, with transaction sizes ranging from $0.25 million to $0.75 million.

LaunchCapital, established in 2008, is a venture capital firm headquartered in New Haven, Connecticut, with additional offices in Boston, New York, and San Francisco. The company invests in early-stage startups, focusing on seed rounds with investments typically ranging from $50,000 to $150,000. LaunchCapital supports entrepreneurs across various sectors, including commerce, marketplace, consumer, media, entertainment, enterprise software, emerging tech, data, finance, healthcare, and medical technology. The firm employs two distinct investment strategies: LaunchCapital Ventures, which follows a traditional equity model for high-growth opportunities, and LaunchCapital Small Business, which offers a blend of equity and debt financing for businesses with linear growth expectations and local or regional reach.

Founded in 1969, F-Prime Capital is a venture capital firm based in Cambridge, Massachusetts. It invests globally in technology and healthcare sectors, supporting entrepreneurs with its extensive domain expertise and relationships.

Established in 2021, Workshop Ventures is a Boston-based venture studio focused on investing in and supporting early-stage companies within the education (edtech) and climate technology sectors.

Ten Eleven Ventures is a cybersecurity-focused, global venture capital firm that backs cybersecurity companies across stages worldwide, addressing digital security needs. The firm identifies, funds, and helps grow top cybersecurity businesses by leveraging its team, network, and experience. Since its founding, it has raised over $1 billion and completed around 40 cybersecurity investments, including KnowBe4, Darktrace, Twistlock, Verodin, Cylance, and Ping Identity.

Pillar VC is a Boston-based venture capital firm established in 2016 that provides early capital and supports founders from inception through growth. It backs university spinouts led by first-time founders as well as serial entrepreneurs, aiming to build meaningful, scalable companies. The firm focuses on high-potential ventures across machine intelligence, AI, hardware, enterprise software, blockchain, quantum, digital health, and synthetic biology, and offers connections, coaching, and a community to help founders develop personally and professionally. Pillar VC is open to ventures of various types and emphasizes hands-on support and collaboration to accelerate progress.

TVM Capital is a private equity and venture capital firm established in 1983 and headquartered in Munich, with offices across Europe, the United States, the Middle East and Asia. It provides early-stage through growth investments in life sciences, including biopharma, diagnostics, medtech, digital health, and in information and communications technology spanning software, semiconductors, telecommunications and related services. The firm typically invests between modest seven figures and low tens of millions of euros, often taking majority stakes in portfolio companies and supporting growth to market readiness, licensing, or global expansion. Exits are pursued through initial public offerings or sales to strategic buyers. The firm favors investments in Western markets, with attention to cross-border licenses and international collaboration.

Longwood Fund is a Boston-based venture capital firm that creates and invests in science-based companies developing novel solutions for important medical problems. The firm concentrates on healthcare and life sciences, including biotechnology, pharmaceuticals, oncology, and healthtech, supporting ventures from discovery through development with capital and strategic guidance. Established in 2010, Longwood seeks to translate laboratory advances into clinically meaningful products by backing companies built on strong scientific foundations and collaborations with leading research institutions. Through its investments, the firm aims to advance therapies and technologies that address unmet medical needs and improve patient outcomes.

Asahi Kasei Corporate Venture Capital is the venture capital arm of Asahi Kasei Corporation. It makes multi-stage investments in global start-ups and growth companies that are strategically aligned with Asahi Kasei's businesses, focusing on materials, homes, and healthcare, with emphasis on energy, environment, dialysis, and bioprocess fields. The firm seeks innovative companies that can create long-term opportunities for the parent company and deliver synergies with its core operations. It is based in Menlo Park, California, with offices in Boston and Tokyo to source deals and support portfolio companies across major markets.

Founded in 2007, Mass Medical Angels is a venture capital firm based in Brookline, Massachusetts. It specializes in seed and early-stage investments, focusing on life science and healthcare sectors including medical devices, therapeutics, diagnostics, health services, health information technologies, and relevant research-related tools.

Established in 2021, Reflect Ventures is a Boston-based venture capital firm focusing on seed and early-stage investments. It identifies promising startups globally, with an emphasis on emerging markets, and supports them through strategic partnerships and expert networks.

Vinyl Capital is a venture capital firm established in 2021 and located in Boston, Massachusetts. The company focuses on investing in innovative businesses within the business-to-consumer (B2C) sector, as well as in media, advertising technology, gaming, technology, and telecommunications. Vinyl Capital aims to support the evolution of consumer purchasing experiences by backing companies that are poised to shape the future of these industries.

SIP Global Partners is a venture capital firm headquartered in Tokyo, Japan, with an additional office in New York. Founded in 2019, it focuses on cross-border investments in early and growth-stage technology companies. The firm backs ventures spanning digital media, immersive technologies such as virtual, augmented and mixed reality, and related areas including Internet of Things, big data and edge computing, smart cities, robotics, fintech, cybersecurity, and digital health. Its investment scope also encompasses AI applications and infrastructure, automation and mobility, advanced manufacturing, quantum computing, new energy and grid technology, network software and security.

Boston Capital Ventures, established in 1982, is a Boston-based private equity firm focused on early-stage investments in the technology sector within the United States. The firm manages private venture capital partnership funds for individual and institutional investors, targeting information technology and software companies.

Hongtai Capital Holdings is a private equity and venture capital firm that specializes direct and fund of funds investments through Aplus Fund and Aplus Capital. For Aplus Fund, it specializes in direct investments covering angel and growth capital stage investments in big data, artificial intelligence, financial technology, consumer education, medical healthcare, cultural entertainment, internet of things, and intelligent manufacturing sectors. For Aplus Capital, it specializes in direct and fund of funds investments through mature stage investments, acquisitions, and industry consolidation in healthcare, new healthcare, health, medical treatment, biotechnology, healthcare education, next generation health diagnostics, alternative energy, advanced manufacturing in Shandong Province, China. For Aplus Capital, the firm prefers to invest in companies with IPO potential. For acquisitions, it typically makes joint acquisitions and acquire majority stakes in portfolio companies. For acquisition of majority stakes, the firm seeks to exit though selling or injecting into listed companies. For industry consolidation, it acquires minority stakes and prefers to exit through reorganization and listing. The firm also specializes in incubation, seed, start-up, early, middle, expansion, late stage, mergers and acquisitions investments. It typically invests in relaxation entertainment, media, culture, education, cultural sports, technology, information technology, mobile internet, network security, smart hardware, telecommunication, consumer, online consumer, food, beverage, leisure, environmental protection, pharmaceuticals, mobile agriculture, environment-friendly new materials, creativity, chain-style business, retail, and sensor technology, finance, internet finance, mobile internet products overturning industry models, new consumer, new technology, new finance, and new education sectors. The firm invests in non-listed companies and in companies listed in the new third board. It seeks to invest in Silicon Valley and Boston, U.S.A. The firm typically invests CNY 0.5 million (USD 74,903.00) to CNY 500 million (USD 81.61 million) per portfolio company. It prefers to invest in companies with a maximum valuation of USD 100 million. Hongtai Capital Holdings was founded on November 26, 2014 and is based in Beijing, China.

Brewer Lane Ventures is an early-stage venture capital firm based in Boston, Massachusetts. It focuses on investing in insurance technology and financial technology companies, backing founders who aim to transform the market for companies and consumers. The firm emphasizes that technology should improve people’s lives and partners with entrepreneurs dedicated to meaningful industry change. Founded in 2019, Brewer Lane Ventures seeks to support initiatives that advance efficiency, accessibility, and innovation in insurance and finance.

Mendoza Ventures is a venture capital firm based in Boston that focuses on seed and early-stage investments in financial technology, information technology, artificial intelligence and cybersecurity. Led by Adrian and Senofer Mendoza, the firm emphasizes diverse leadership in its portfolio, supporting startups led by immigrants, people of color, and women. Since its inception in 2016, Mendoza Ventures has built a team of operating partners from large organizations and engages strategic investors to help portfolio companies scale. The firm expanded with a San Francisco office in 2022 and has pursued a third fund anchored by Bank of America to back Series A to C rounds. Mendoza Ventures aims to back founders across the fintech and technology sectors, leveraging sector expertise and a network to help early-stage companies grow.