IndieBio, founded in 2014 and based in San Francisco, is the world’s first accelerator dedicated to startups that leverage biology to address significant global challenges. As part of SOSV, a global venture capital firm, IndieBio focuses on nurturing seed-stage and early-stage companies across various sectors, including healthcare, life sciences, biotechnology, and consumer products. The accelerator provides funding and support to innovative ventures aiming to create impactful solutions in areas such as pharmaceuticals, oncology, and advanced manufacturing. By fostering emerging technologies and biological applications, IndieBio plays a crucial role in advancing the next generation of startups that seek to make a positive difference in society.
Capro-X Inc. is an ag-tech company focused on enhancing sustainability in the dairy industry by addressing the issue of acid whey waste, particularly from Greek yogurt production. Founded in 2017 and based in Ithaca, New York, Capro-X has developed a fermentation bioprocess technology known as WheyAway. This innovative treatment utilizes naturally occurring, non-GMO microbes to convert dairy waste streams into clean water and valuable bio-oils. The process occurs at the site of waste generation, allowing for efficient management of by-products. Capro-X also produces caproic acid, marketed as CPRX1060, which further contributes to the upcycling of dairy waste into useful materials. Through its solutions, the company aims to promote sustainability and improve operational efficiency within the dairy sector.
Materia Bioworks sees a future in which sustainability and innovation coexist. They envision a time when advanced biomaterials will be easily accessible and will spur constructive transformation in a variety of industries.
Prellis Biologics, Inc. specializes in creating human tissues for drug development and the eventual production of human organs for transplantation. Founded in 2016 and based in San Francisco, California, the company employs advanced bioprinting technology to develop vascularized human tissues and organs, aiming to overcome the challenges associated with microvasculature. Its innovative products include TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X. Prellis Biologics also focuses on accurately replicating the human immune response through lymph node organoids, which can be utilized for various applications such as antibody discovery and immunogenicity assessment. By addressing critical issues in early-stage drug development and translational pharmacology, Prellis Biologics seeks to improve patient outcomes in healthcare.
CKapur develops a biological product that specializes in the agricultural sector. It focuses on improving crop nutrition using extremophile microorganisms. It is located in Buenos Aires, Argentina.
Particella specializes in the development of innovative lipid nanoparticle technology designed for the oral delivery of mRNA and other nucleic acids. This proprietary approach aims to transform the way biological medicines are administered by utilizing the intestinal tract to secrete proteins into the bloodstream, effectively allowing for the conversion of protein biologics into oral drugs. The company’s technology seeks to address existing limitations in the delivery of biological medicines, presenting potential advancements in preventing gastrointestinal diseases in patients.
Ten63 Therapeutics is a biotechnology company focused on developing innovative therapeutics for challenging diseases, particularly those involving targets previously considered undruggable. Founded in 2017 and based in Chapel Hill, North Carolina, the company utilizes its proprietary platform, COPPER, which integrates advanced artificial intelligence and state-of-the-art physical models to explore vast chemical spaces. By employing low-residual, machine learning-based computational chemistry alongside superlinear search algorithms, Ten63 Therapeutics aims to identify and optimize drug candidates effectively. Their approach includes proprietary scaffold redesign and hopping technology, enabling the screening of trillions of molecules to predict resistance and redesign antibodies. This combination of techniques positions Ten63 Therapeutics at the forefront of developing durable treatments for some of the most lethal diseases.
Farm Minerals is rewriting the rules of agriculture. We’ve built the world’s first emissions-free NPK fertilizers at market price — no green premium, no tradeoffs. Powered by our proprietary carbon capsule tech, we deliver nutrients in their most bioavailable form, boosting efficiency by up to 100x compared to traditional inputs. We don’t use the outdated, emission-heavy Haber-Bosch process. That means zero CO₂ in production, no runoff, no waste — targeted delivery, healthier soil, and bigger yields with less input. Our product line combines essential macroelements for plant growth with a full spectrum of microelements that boost crop performance and support animal health — all designed for maximum impact from seed to harvest.
Giraffe Bio is a developer of biomolecular technology to improve efficiency and sustainability in critical mineral extraction. The company’s platform customizes biomolecules to each mine’s unique geology, enhancing metal recovery, reducing water use, and minimizing environmental impact.
AlkaLi Labs is a biotechnology research company based in San Francisco, California, established in 2023. The company focuses on developing biological solutions to harness domestic mineral resources. Currently operating in stealth mode, AlkaLi Labs aims to innovate in the field of biotechnology, leveraging biological processes to unlock valuable minerals.
Unlocked Labs specializes in developing innovative probiotics aimed at addressing chronic health conditions by utilizing genetically optimized microbial strains. The company focuses on activating dormant microbial abilities to effectively digest compounds that can lead to health issues. Their first product targets the risk of kidney stones by breaking down stone-forming compounds derived from healthy foods like leafy vegetables. Unlocked Labs employs alternative regulatory pathways to expedite the availability of safe and effective probiotic solutions for consumers. By harnessing the natural detoxifying capabilities of symbiotic microbes, their products aim to reduce acid levels in the body, making them both affordable and accessible to a wide audience.
VIAN Therapeutics is an early-stage biotechnology company dedicated to innovating treatments for retinal diseases. The company is developing a first-in-class, non-invasive eyedrop intended to replace traditional injections for conditions such as age-related macular degeneration and diabetic macular edema. With robust preclinical data and ongoing clinical trials, VIAN aims to meet significant unmet medical needs in the retinal disease market, which is valued at $15 billion. Additionally, the company is engaged in the creation of peptide drugs that enhance efficacy and safety for treating both ophthalmic and oncology-related conditions by targeting angiogenesis, thereby offering patients improved health outcomes.
Asterix Foods is a biotechnology company based in Tel Aviv, Israel, founded in 2022. The company specializes in developing protein production using plant-cell culture techniques. Its platform focuses on creating bioactive proteins for food that are scalable, functional, and complex. Asterix Foods aims to provide users with plant cell-cultured and animal-free proteins, contributing to innovative and sustainable food solutions.
Sci-Lume Labs creates new biobased and biodegradable fibres to replace traditional petrochemical fibres such as nylon and polyester. This high-performance, drop-in ready fibre will be used by textile and apparel manufacturers to address the environmental concerns associated with synthetic fibres while maintaining the performance and versatility of conventional synthetics.
Sun Genomics is a precision nutrition company focused on curing dysbiosis through the gut microflora and personalized solutions. Its flagship product Floré, is a microbiome test and custom synbiotics solution that utilizes whole-genome sequencing to evaluate different digestive system data points and ensure that customers receive a completely personalized product based on their unique gut profiles. The company also offers: Floré Tots, Kids, and Baby, available for kids up to age 0-12, and comes in an easy digestive powder to mix with their favorite drink. Floré Clinical, which is specifically for professional practitioners and their patients. Floré Defense, Balance, and Performance for sports teams and athletes.
Capra Biosciences is a biotechnology company focused on the efficient and low-carbon production of everyday chemicals through innovative bioreactor technology. The company has developed a biofilm bioreactor platform that aims to enhance the bio-manufacturing process by significantly reducing downstream processing requirements and associated costs. This technology facilitates the production of a variety of bio-based chemicals, including hydrophobic products like retinol and performance lubricants, thus advancing sustainable practices in the chemical industry.
Laguna Bio provides a drug discovery platform designed that activates and expands the innate immune system against cancer. It focuses on providing a specific type of T cell for the immune system to fight solid tumors by increasing the response rate of a bispecific antibody drug. Laguna Biotherapeutics was founded in 2022 and is headquartered in Berkeley, California.
Bactery specializes in the production of bacteria-powered batteries, which are capable of self-recharging through microbial processes found in soil. These environmentally friendly batteries offer a continuous supply of clean electricity, independent of weather conditions or geographical location. This innovative technology serves as an ideal power source for remote applications, particularly in agricultural settings, where it can effectively support field sensors and Internet of Things (IoT) devices. Bactery's commitment to sustainable energy solutions positions it as a key player in the renewable energy sector.
Huue is a company focused on providing sustainable dyeing solutions for the denim and textile industries, specifically through the use of bio-synthesized indigo dyes. By employing fermentation biotechnology, the company utilizes naturally occurring microorganisms to produce colors, which significantly reduces the reliance on toxic chemicals traditionally used in dye production. This innovative approach not only enhances the environmental sustainability of the denim supply chain but also offers a greener alternative for fashion and textile manufacturers seeking to create eco-friendly products. Huue's commitment to harnessing renewable resources positions it as a leader in the movement towards more sustainable practices in the industry.
Minutia is focused on developing innovative solutions for Type 1 Diabetes through stem cell-derived transplants that incorporate nanosensors. The company specializes in creating subcutaneous insulin-producing cell transplants that are immune-evasive and capable of real-time monitoring via proprietary cell-based sensors. This approach aims to address common challenges associated with transplants and seeks to provide a functional cure for diabetes. By advancing both transplantation techniques and monitoring capabilities, Minutia aspires to transform the clinical landscape of diabetes management and cell replacement therapies.
Sóliome is a Biotechnology company that develops protein-based sunscreens that are safe. The company was founded in 2021 and is based in San Francisco, California.
Gatehouse Bio is a biotechnology company based in Waltham, Massachusetts, focused on the accelerated development of therapies utilizing small ribonucleic acid (RNA) and advanced bioinformatics. Founded in 2016, the company has developed a platform that employs artificial intelligence to identify error-free RNA biomarkers and discover disease-associated mutations. This platform enables precise classification of patient samples, which aids in the design of targeted therapeutics aimed at addressing various diseases, particularly in areas characterized by known heterogeneity such as fibrosis, inflammation, and neurodegeneration. By analyzing small RNA genes, Gatehouse Bio aims to unlock the potential for innovative treatments that could significantly enhance patient outcomes.
Calyx develops advanced sensor platforms that monitor various parameters in poultry and livestock, utilizing cutting-edge technology to address complex challenges in the industry. The company specializes in gas sensor technology that detects airborne chemical emissions through innovative sensors patterned with viruses that bind to specific gas molecules. These sensors provide high specificity and sensitivity, changing color in response to different gases and their concentrations. By integrating artificial intelligence, computer vision technology, and data science, Calyx aims to enhance environmental monitoring and improve health outcomes for livestock and poultry, offering commercial customers effective solutions to track daily environmental changes.
PhytoGenesis leverages plant-based compounds to develop safe and non-toxic alternatives to fungicides and other pesticides. The technology ensures efficacy across a wide range of grain, feed, fiber, oil, vegetable, and fruit crops. The company focuses on providing sustainable agricultural solutions that minimize environmental impact while maintaining crop health and productivity.
microTERRA is focused on creating sustainable food ingredients by utilizing the unique properties of Lemna, an aquatic plant known for its ability to purify water while generating valuable functional ingredients. One of its key products, Flora, enhances sweetness perception and allows for reduced sugar content in food formulations, effectively masking undesirable flavors from high-intensity sweeteners. This innovative approach positions microTERRA within a substantial market opportunity in the food industry. As an ingredient platform, the company aims to develop additional specialty ingredients in a sustainable manner, contributing to a more environmentally friendly food supply chain.
Capro-X Inc. is an ag-tech company focused on enhancing sustainability in the dairy industry by addressing the issue of acid whey waste, particularly from Greek yogurt production. Founded in 2017 and based in Ithaca, New York, Capro-X has developed a fermentation bioprocess technology known as WheyAway. This innovative treatment utilizes naturally occurring, non-GMO microbes to convert dairy waste streams into clean water and valuable bio-oils. The process occurs at the site of waste generation, allowing for efficient management of by-products. Capro-X also produces caproic acid, marketed as CPRX1060, which further contributes to the upcycling of dairy waste into useful materials. Through its solutions, the company aims to promote sustainability and improve operational efficiency within the dairy sector.
Oobli specializes in the development of healthy, protein-based sweeteners sourced from exotic plants. These unique compounds offer a flavorful experience without the calories typically associated with sugar, making them a suitable alternative for health-conscious consumers. The protein sweeteners are produced through fermentation, ensuring they have no glycemic impact and do not disrupt the gut microbiome. Oobli has successfully obtained regulatory approvals, including FDA "no questions" letters and GRAS status for several of its proteins, reinforcing their commitment to safety and quality. By providing a delicious and low-calorie option, Oobli aims to transform the way individuals approach sweeteners, allowing for healthier choices in everyday consumption.
CellCrine
Seed Round in 2024
CellCrine focuses on discovering enzymes that transform cell culture for the cell-based meats industry. CellCrine was founded in 2021and was headquartered in United, States.
MycoWorks is a biotechnology company focused on developing sustainable, non-plastic and non-animal materials. Utilizing fungal mycelium, the company creates biodegradable alternatives to plastic foams, synthetic textiles, engineered woods, and leather. Their innovative products are designed for various applications, including aerospace, automobiles, apparel, and architectural interiors. By leveraging agricultural byproducts in a carbon-negative process, MycoWorks enables clients to access new types of leather that are grown rapidly and sustainably. This approach not only addresses environmental concerns but also offers practical solutions for industries seeking eco-friendly materials.
NovoNutrients is focused on converting industrial waste carbon dioxide emissions into high-value protein and additives for food and feed. The company has developed a fermentation platform that utilizes proprietary microbes and advanced gas fermentation systems to transform CO2, along with hydrogen and oxygen, into safe and natural single-cell protein ingredients. This innovative approach enables the food industry to access sustainable protein sources, addressing the needs of a growing global population while also contributing to climate change mitigation through effective carbon capture and utilization.
OncoPrecision is a company that focuses on improving cancer therapy outcomes by utilizing a patient micro avatar platform. This innovative platform employs single-cell high-throughput biology and machine learning to generate comprehensive patient-derived phenotypic biomarkers. By doing so, it enables oncologists to make informed, data-driven decisions regarding the selection of cancer therapies tailored to individual patients. The approach aims to increase the success rates of cancer treatments by ensuring that the right therapy is matched to the right patient, thus enhancing overall patient care and treatment effectiveness.
Avalo is a plant biology company that employs interpretable machine learning, genomic discovery, and evolutionary theory to innovate crop development for future agricultural needs. Utilizing AI-assisted plant breeding, Avalo ensures that all its products are non-GMO and promote natural biodiversity. The company's core technology is a discovery engine that efficiently identifies the genetic foundations of complex traits, significantly shortening the time and reducing the costs associated with developing new crops. By focusing on traits such as drought tolerance, water-use efficiency, and nutrient density, Avalo's platform enhances crop evolution to adapt to changing climate conditions. This approach allows researchers to improve crop quality while providing diagnostic forecasting and gene discovery capabilities, ultimately advancing agricultural practices.
Farm Minerals is rewriting the rules of agriculture. We’ve built the world’s first emissions-free NPK fertilizers at market price — no green premium, no tradeoffs. Powered by our proprietary carbon capsule tech, we deliver nutrients in their most bioavailable form, boosting efficiency by up to 100x compared to traditional inputs. We don’t use the outdated, emission-heavy Haber-Bosch process. That means zero CO₂ in production, no runoff, no waste — targeted delivery, healthier soil, and bigger yields with less input. Our product line combines essential macroelements for plant growth with a full spectrum of microelements that boost crop performance and support animal health — all designed for maximum impact from seed to harvest.
Helex, founded in 2021 and based in New York, specializes in developing innovative genomic medicines specifically for renal conditions. The company leverages its proprietary genomics data and bioinformatics platform to create, verify, and distribute therapy-specific guide RNAs (gRNAs). By employing data-driven deep-learning models and high throughput next-generation sequencing data from CRISPR edits on human cell lines, Helex provides reliable predictions and validations in-house. This approach supports clients in expediting the development of CRISPR-based drug discovery and cell and gene therapies, emphasizing non-viral targeted delivery and genome editing for kidney-related therapies.
Developing increasingly challenging vaccine targets requires increasingly sophisticated technologies. Over the last century, vaccines have made essential contributions to the doubling of human life expectancy. Calder engineers next-generation vaccines that will further protect against the most intractable and life-threatening viruses. Viruses have evolved to become shapeshifters that can evade and distract our immune system by hiding some of their most vulnerable sites. History has shown that pandemics are not only lethal but also inevitable. Currently, the vaccines we know best poorly protect against pandemics and other viral outbreaks and leave many at-risk populations unprotected. By combining structure-based design as part of a novel manufacturing process, Calder’s unique 3D-Vaxlock technology generates molecular staples that lock vaccines into their most potent shape. Their initial focus is on generating a universal flu vaccine that protects against all seasonal strains and an RSV vaccine specifically for the elderly. With this platform, they have the ability to create treatments that better protect against life-threatening diseases with exceptional safety, efficacy, and durability. Calder’s next generation vaccines will prevent severe disease and deaths, alleviate a substantial burden on the healthcare system, and allow billions of people to lead healthy lives.
ClimateCrop is an agriculture technology company founded in 2021 and based in Ness Ziona. The company specializes in gene editing to enhance the ability of plants to store carbon and energy, thereby increasing crop yields in biomass and fruit production. By improving the resilience of crops to extreme weather conditions, ClimateCrop enables agricultural companies to better adapt to current and future climate challenges, ultimately leading to more sustainable and productive farming practices.
Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on growing marine-animal cells to create alternatives to traditional fish and seafood, including bluefin tuna. By offering a variety of responsibly produced food options, Finless Foods aims to cater to diverse tastes and dietary needs while promoting sustainability and better ocean health. The company's innovative approach provides consumers with healthy and accessible seafood alternatives, enabling them to maintain a balanced diet without compromising on flavor or variety.
Bloomlabs provides a method to catalyze waste value by regenerating it as adaptable and appealing bio-plastics and textile fibers. It envisions a future in which outmoded, resource-intensive processes are phased out in favor of cutting-edge, sustainable, and scalable alternatives.
Cayuga Biotech is a startup focused on developing innovative hemostatic drugs and devices aimed at reducing uncontrollable bleeding, a leading cause of death from traumatic injuries. The company utilizes a polyphosphate-based drug that enhances the body's natural clotting ability, effectively promoting clot formation at injury sites while minimizing potential side effects. Cayuga's product pipeline includes a clinic-ready drug for life-threatening bleeding and therapeutics in the discovery stage for rare inherited bleeding disorders, central nervous system bleeding, severe burns, and non-healing wounds. By harnessing the body's innate coagulation response, Cayuga Biotech aims to improve survival rates and reduce disability associated with trauma.
California Cultured is a food company creating sustainable, lab-grown cocoa that is less bitter and requires less sugar to be tasty. It produces cocoa intended to provide cocoa that is less bitter and requires less sugar. The company's product entices cocoa cells to grow by stimulation by food ingredients that are found in any grocery store and produce cocoa cells that is good for human health, enabling customers to avail premium quality cocoa products. California Cultured was founded in 2020 and is headquartered in Davis, California.
NuKoKo is a bean-to-bar manufacturing company specializing in cocoa-free chocolate. By utilizing ingredients sourced from the UK, the company has developed a patent-pending technology that allows for the production of a novel type of chocolate. This innovative product is designed to be healthier and has a significantly reduced environmental impact compared to traditional chocolate production methods. NuKoKo's offerings are characterized by low carbon emissions, low sugar content, and high protein, catering to consumers seeking sustainable and nutritious alternatives in the chocolate market.
AquaLith Advanced Materials specializes in the development of innovative lithium-ion battery materials. The company has secured exclusive rights to a portfolio of patents from the University of Maryland, which focus on advancements made by researchers in the field of chemical and materials engineering. AquaLith's technology includes an ultra-high energy cathode, a novel silicon anode, and a non-flammable aqueous electrolyte, all designed to enhance the performance of lithium-ion batteries. This technology addresses key challenges such as efficiency in low temperatures, faster charging times, and improved safety by reducing fire risks associated with short circuits. The company's materials aim to provide high energy density while being cost-effective and abundant, ultimately benefiting consumer electronics and other applications in need of reliable battery solutions.
Avisa Myko Inc. is a biotechnology company based in San Francisco, California, specializing in the production of natural, water-soluble melanin. The company has developed a patented technology that allows for the large-scale and cost-effective manufacturing of melanin, which is used across various industries, including cosmetics, biomedicine, and environmental applications. Avisa Myko's melanin offers protection against ionizing radiation and is integrated into products such as latex, fabrics, laminated plastics, and glass. Additionally, the company is working on formulating a sunscreen that utilizes melanin as a natural ultraviolet blocker, eliminating the need for traditional chemical or mineral UV filters. By focusing on sustainable solutions, Avisa Myko aims to enhance human health and environmental safety through its innovative melanin products.
Producer of plant-based protein intended to decarbonize supply chains by creating valuable products from underutilized waste from other industries. The company offers a sustainable plant-based protein that is produced from spent grains by transforming the unused part of the grain from beer manufacturing into functional vegan protein, enabling clients to get products that replace the need for soy and pea protein in meat and dairy replacements
Bioeutectics focuses on creating environmentally friendly industrial products by providing high-performance, natural solvents. Utilizing proprietary eutectic technology, the company produces solvents that mimic the natural processes of plants, using 100% renewable resources. This innovation allows Bioeutectics to replace traditional petrochemical solvents in various industrial applications, promoting sustainability. Their product line caters to diverse sectors, including food, pharmaceuticals, and personal care, and is designed to be non-toxic, biodegradable, and customizable to meet specific industry needs. Through these advancements, Bioeutectics aims to lead the market in offering sustainable alternatives that enhance environmental responsibility in industrial processes.
ZymoChem, Inc. is a biotechnology company based in Emeryville, California, founded in 2013. It specializes in the development of eco-friendly chemicals and bioprocesses using engineered microbes to convert renewable feedstocks, such as sugars, into industrial chemicals. The company’s bio-manufacturing platform aims to produce bio-based materials while minimizing carbon emissions during production, thereby supporting a carbon-efficient economy. By establishing cost-effective bioprocesses and novel biosynthetic pathways, ZymoChem enables clients to reduce production costs and enhance their competitiveness in the market. Through its innovative approach, the company contributes to sustainable manufacturing practices and the advancement of a real-zero economy.
Chronus Health, Inc. is a company that specializes in developing a portable diagnostic platform aimed at delivering rapid point-of-care lab results, specifically for complete blood count and comprehensive metabolic panel tests. Founded in 2017 and based in Mountain View, California, the company's innovative system utilizes microfluidics and semiconductor technology, combined with data analytics, to provide healthcare providers with real-time test results. This capability allows for immediate diagnosis at the point of care, enhancing the efficiency of treatment and significantly improving patient outcomes. By enabling doctors to obtain lab results in minutes, Chronus Health facilitates timely decision-making in clinical settings.
Voyage Foods is focused on creating sustainable and scalable alternatives to popular food products that face challenges due to health, environmental, and social issues. The company utilizes natural, sustainable, and upcycled ingredients along with proprietary technology and food science to develop new food items that replicate the taste and appearance of traditional favorites. Their product offerings include Nut-Free Spreads, Cocoa-Free Chocolate, and Bean-Free Coffee, all designed to provide the same enjoyment without compromising individual health or environmental integrity. This innovative approach allows consumers to savor their favorite foods while contributing to a more responsible food system.
Sun Genomics is a precision nutrition company focused on curing dysbiosis through the gut microflora and personalized solutions. Its flagship product Floré, is a microbiome test and custom synbiotics solution that utilizes whole-genome sequencing to evaluate different digestive system data points and ensure that customers receive a completely personalized product based on their unique gut profiles. The company also offers: Floré Tots, Kids, and Baby, available for kids up to age 0-12, and comes in an easy digestive powder to mix with their favorite drink. Floré Clinical, which is specifically for professional practitioners and their patients. Floré Defense, Balance, and Performance for sports teams and athletes.
Unlocked Labs specializes in developing innovative probiotics aimed at addressing chronic health conditions by utilizing genetically optimized microbial strains. The company focuses on activating dormant microbial abilities to effectively digest compounds that can lead to health issues. Their first product targets the risk of kidney stones by breaking down stone-forming compounds derived from healthy foods like leafy vegetables. Unlocked Labs employs alternative regulatory pathways to expedite the availability of safe and effective probiotic solutions for consumers. By harnessing the natural detoxifying capabilities of symbiotic microbes, their products aim to reduce acid levels in the body, making them both affordable and accessible to a wide audience.
RyboDyn is a biotechnology research company focused on developing innovative therapeutics aimed at training the immune system to detect and eliminate cancer from within the body. The company is dedicated to advancing scientific breakthroughs that lead to new classes of treatments, providing significant improvements in medicine. RyboDyn's work is particularly concentrated on creating upgraded therapies for serious diseases, including terminal conditions, with the goal of enhancing patient outcomes and expanding treatment options.
Prellis Biologics, Inc. specializes in creating human tissues for drug development and the eventual production of human organs for transplantation. Founded in 2016 and based in San Francisco, California, the company employs advanced bioprinting technology to develop vascularized human tissues and organs, aiming to overcome the challenges associated with microvasculature. Its innovative products include TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X. Prellis Biologics also focuses on accurately replicating the human immune response through lymph node organoids, which can be utilized for various applications such as antibody discovery and immunogenicity assessment. By addressing critical issues in early-stage drug development and translational pharmacology, Prellis Biologics seeks to improve patient outcomes in healthcare.
Hypercell Technologies develops tools to control infectious diseases in animals. Hypercell believes that the best chance to stop a future pandemic in humans is to prevent it by proactively controlling viruses in production animal reservoirs.
Lillianah is a team of scientists dedicated to addressing environmental challenges through innovative carbon capture technology. Their focus is on optimizing the biological pump in oceans to restore balance to marine ecosystems adversely affected by pollution, fertilizer runoff, and various external factors. By harnessing the potential of oceans, Lillianah aims to reverse the negative impacts on the environment, contributing to a healthier planet.
BioFluff specializes in the production of plant-based fur aimed at replacing traditional animal and plastic furs in the fashion industry. Utilizing a patented process along with retrofitted equipment for faux-fur manufacturing, the company is establishing a scalable production model for its sustainable materials. BioFluff's products are made from organic renewable fiber plants and are developed without gene splicing, gene editing, or the use of petrochemicals and unsustainable raw-oil derivatives. Additionally, the company offers customization services, allowing customers to personalize various aspects of their products, including fur length, fiber density, color, and insulation properties. This commitment to sustainability positions BioFluff as a leader in providing luxury materials that align with eco-friendly practices.
Pyrone Systems is a company focused on developing biopesticides that integrate biological and chemical principles to create safe and effective products. Founded in 2021, the company employs scalable methodologies to produce bio-based solutions that aim to replace harmful petrochemicals. By prioritizing sustainability, Pyrone Systems seeks to offer environmentally friendly alternatives in the agrochemical industry, thereby contributing to a reduction in the use of hazardous substances.
BioAesthetics LLC, founded in 2015 as a spin-out from Tulane University, is focused on developing innovative reconstruction options for breast cancer patients following mastectomies. The company specializes in a tissue-engineered nipple-areolar complex (NAC) that serves as an acellular graft to be used by plastic and reconstructive surgeons during the breast reconstruction phase. This product allows the patient's own cells to integrate with the graft, facilitating the regeneration of a natural nipple and areola. Currently in the pre-clinical phase, this patent-pending technology aims to provide a more effective and aesthetically pleasing solution for patients who have experienced incomplete or removed NACs due to illness, surgery, or congenital conditions. BioAesthetics is headquartered in Research Triangle Park, North Carolina.
Gatehouse Bio is a biotechnology company based in Waltham, Massachusetts, focused on the accelerated development of therapies utilizing small ribonucleic acid (RNA) and advanced bioinformatics. Founded in 2016, the company has developed a platform that employs artificial intelligence to identify error-free RNA biomarkers and discover disease-associated mutations. This platform enables precise classification of patient samples, which aids in the design of targeted therapeutics aimed at addressing various diseases, particularly in areas characterized by known heterogeneity such as fibrosis, inflammation, and neurodegeneration. By analyzing small RNA genes, Gatehouse Bio aims to unlock the potential for innovative treatments that could significantly enhance patient outcomes.
Diptera.ai, based in Jerusalem, Israel, specializes in innovative mosquito control solutions. The company focuses on a biological method that utilizes sterile insect techniques, specifically by releasing sterile male mosquitoes through a ready-to-use module over a period of weeks. This technology incorporates advanced optics, computer vision, and artificial intelligence, making it both affordable and accessible for municipal corporations. By eliminating the need for mosquito rearing and sorting facilities, Diptera.ai enables large-scale mosquito control efforts, addressing public health concerns efficiently.
Developing increasingly challenging vaccine targets requires increasingly sophisticated technologies. Over the last century, vaccines have made essential contributions to the doubling of human life expectancy. Calder engineers next-generation vaccines that will further protect against the most intractable and life-threatening viruses. Viruses have evolved to become shapeshifters that can evade and distract our immune system by hiding some of their most vulnerable sites. History has shown that pandemics are not only lethal but also inevitable. Currently, the vaccines we know best poorly protect against pandemics and other viral outbreaks and leave many at-risk populations unprotected. By combining structure-based design as part of a novel manufacturing process, Calder’s unique 3D-Vaxlock technology generates molecular staples that lock vaccines into their most potent shape. Their initial focus is on generating a universal flu vaccine that protects against all seasonal strains and an RSV vaccine specifically for the elderly. With this platform, they have the ability to create treatments that better protect against life-threatening diseases with exceptional safety, efficacy, and durability. Calder’s next generation vaccines will prevent severe disease and deaths, alleviate a substantial burden on the healthcare system, and allow billions of people to lead healthy lives.
BryoSphere is a company specializing in the manufacturing of specialty chemicals, employing moss plants and biotechnology methods in the production of their goods. The company is currently focused on the development of two key products: one for addressing skin hyperpigmentation in topical treatments, and another as an anti-cancer drug.
Xias Bio is a biotechnology startup focused on producing recombinant proteins that enhance the delivery of functional ingredients for various sectors, including research, beauty, and healthcare. The company specializes in developing non-immunogenic natural motifs, which provide a superior platform for creating soluble and active ingredients with desirable properties such as improved gel and film formation and antioxidant effects. By offering an adaptable, animal product-free biomaterial, Xias Bio delivers tailored biological functionalities that outperform traditional synthetic and animal-based products. This innovation enables pharmaceutical and cosmetic companies to access non-toxic, non-immunogenic alternatives for a wide range of applications.
Producer of plant-based protein intended to decarbonize supply chains by creating valuable products from underutilized waste from other industries. The company offers a sustainable plant-based protein that is produced from spent grains by transforming the unused part of the grain from beer manufacturing into functional vegan protein, enabling clients to get products that replace the need for soy and pea protein in meat and dairy replacements
Veloz Bio is a biotechnology company that uses molecular farming to create and manufacture animal-free and alternative proteins. The company was founded in 2021 and is based in Monterrey, Nuevo León.
QuantumCyte, Inc. is a technology platform company based in Sunnyvale, California, that specializes in cell analysis systems aimed at predicting drug efficacy and improving cancer treatment outcomes. Founded in 2014, QuantumCyte develops automated microdissection solutions for molecular pathology, utilizing digital tissue maps to isolate regions of interest that contain important biomarkers. By harnessing artificial intelligence in digital pathology, the company enables healthcare providers to perform precise single-cell analysis, enhancing the understanding of immune system and cancer biology.
NuKoKo is a bean-to-bar manufacturing company specializing in cocoa-free chocolate. By utilizing ingredients sourced from the UK, the company has developed a patent-pending technology that allows for the production of a novel type of chocolate. This innovative product is designed to be healthier and has a significantly reduced environmental impact compared to traditional chocolate production methods. NuKoKo's offerings are characterized by low carbon emissions, low sugar content, and high protein, catering to consumers seeking sustainable and nutritious alternatives in the chocolate market.
Cell BioEngines, Inc. is a clinical-stage biotechnology company dedicated to the development of allogeneic "off-the-shelf" stem cell therapies for the treatment of various human diseases, with a particular focus on oncology. The company has created a blood stem cell-derived epigenetic platform designed to address challenges related to donor source availability, cellular potency, and the complexities of manufacturing clinical-grade cell products. By leveraging this innovative platform, Cell BioEngines aims to produce cell-based therapies that can provide long-lasting benefits to patients, ultimately striving to transform cancer into a curable disease.
CroBio Ltd is an agricultural biotechnology company based in Macclesfield, United Kingdom, founded in 2019 by experts in microbiology and engineering. The company focuses on developing environmentally sustainable solutions to combat global agricultural drought. Its technology leverages genetically engineered root-associated bacteria that produce a sponge-like biomaterial, facilitating biologically active water retention in soil. This innovative approach aims to improve soil health and enhance water management in agricultural practices.
Avisa Myko Inc. is a biotechnology company based in San Francisco, California, specializing in the production of natural, water-soluble melanin. The company has developed a patented technology that allows for the large-scale and cost-effective manufacturing of melanin, which is used across various industries, including cosmetics, biomedicine, and environmental applications. Avisa Myko's melanin offers protection against ionizing radiation and is integrated into products such as latex, fabrics, laminated plastics, and glass. Additionally, the company is working on formulating a sunscreen that utilizes melanin as a natural ultraviolet blocker, eliminating the need for traditional chemical or mineral UV filters. By focusing on sustainable solutions, Avisa Myko aims to enhance human health and environmental safety through its innovative melanin products.
Re-Fresh Global specializes in textile waste management, offering innovative solutions that contribute to the circular economy in textiles. The company employs a patented method to tackle the challenges of textile waste, facilitating smart collection, separation, and low-cost upcycling of large quantities of low-value materials. In addition to its technologies, Re-Fresh Global initiates and implements circular economy projects, providing training and fostering international cooperation. Their services aim to transform textile waste into valuable raw materials, addressing customer inquiries through various channels, including phone, email, and online applications.
Cereswaves is an Agri-Tech startup focused on the research, development, and manufacturing of machinery for the mining, agriculture, and construction sectors. Currently operating in stealth mode, the company aims to innovate within the agricultural technology landscape by creating advanced solutions that enhance efficiency and productivity in these industries.
Bloomlabs provides a method to catalyze waste value by regenerating it as adaptable and appealing bio-plastics and textile fibers. It envisions a future in which outmoded, resource-intensive processes are phased out in favor of cutting-edge, sustainable, and scalable alternatives.
TippingPoint Biosciences is focused on developing therapeutics that address diseases linked to defects in DNA packaging, including various cancers and neurodegenerative disorders. Utilizing a drug discovery platform, the company aims to identify innovative treatments that specifically target unique genome packaging states associated with these diseases. This approach not only facilitates the treatment of cancers but also supports the development of stem cell therapies by addressing the underlying issues of dysfunctional genome packaging. Through its efforts, TippingPoint Biosciences seeks to advance medical care and improve patient outcomes in complex genetic conditions.
Carbonade is a chemical manufacturing company based in Ness Ziona, Israel, founded in 2022. The company specializes in innovative electro-chemical technologies for carbon capture, utilization, and storage (CCUS), focusing on the reduction of carbon dioxide emissions to address climate change. By leveraging renewable electricity, Carbonade's patented solutions offer a scalable method for converting CO2 into valuable carbon-based products such as fuels, plastics, and chemicals. This approach not only mitigates environmental impact but also provides clients with sustainable alternatives in the chemical manufacturing sector.
California Cultured is a food company creating sustainable, lab-grown cocoa that is less bitter and requires less sugar to be tasty. It produces cocoa intended to provide cocoa that is less bitter and requires less sugar. The company's product entices cocoa cells to grow by stimulation by food ingredients that are found in any grocery store and produce cocoa cells that is good for human health, enabling customers to avail premium quality cocoa products. California Cultured was founded in 2020 and is headquartered in Davis, California.
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