ARK Investment Management

Hammerspace is a company that offers a software-defined data orchestration and storage solution designed to provide unified file access across various storage types and locations. Its core technology, the Parallel Global File System, enables organizations to treat data as a global resource, facilitating direct multi-protocol access to files regardless of the underlying storage infrastructure, whether it be on-premises, public cloud, or private cloud. This system efficiently manages metadata, ensuring that all users access the same file information without creating duplicate copies across different storage silos. By leveraging machine learning, Hammerspace virtualizes and abstracts data from the underlying infrastructure, allowing for agile file data-as-a-service capabilities that support seamless application workloads and uninterrupted operations. This innovative approach helps organizations streamline data management and enhance productivity by eliminating complexities associated with traditional storage solutions.

Coinbase Global, established in 2012, operates a leading cryptocurrency exchange platform in the United States. The company facilitates transactions, buying, selling, and storage of digital currencies such as Bitcoin, Ethereum, and Litecoin for both consumers and merchants. Coinbase offers a range of products including Coinbase.com, a user-friendly platform for bitcoin transactions, a global digital asset exchange, merchant tools, and custodial services. The company, headquartered in San Francisco, California, aims to provide a safe and regulation-compliant entry point into the cryptocurrency economy.

Lucra Sports is a social sports gaming platform that combines elements of sports gaming and fantasy sports. It allows users to create fantasy leagues and engage in skill-based activities across various domains, including sports, yard games, drinking games, board games, and video games. The platform facilitates friendly competition by enabling users to stake money on the performances of players, enhancing the social aspect of gaming while fostering a community of sports enthusiasts.

Sortium is an entertainment technology startup that merges artificial intelligence and Web3 to create a content generation platform. This platform facilitates the real-time production and modification of 3D assets and textures through natural language processing. By automating the tokenization of game content, Sortium enables simulated live gameplay balance while allowing users to streamline economic simulations and behavioral modeling. The company's innovative approach enhances the efficiency and quality of content creation for businesses involved in gaming and virtual productions.

Relation Therapeutics is a biotechnology company focused on advancing drug discovery and development. It utilizes human genetics and clinical omics data, alongside patient-derived tissue samples, to identify and validate therapeutic programs. The company employs machine learning to explore the relationships between genes, proteins, and drugs, generating insights that have real translational validity. By combining single-cell multi-omics from patient tissues with functional assays, Relation Therapeutics aims to deepen the understanding of biological processes in human health and disease. This approach enables healthcare providers to discover and develop novel treatments, particularly in areas with unmet medical needs.

Shield AI Inc is an artificial intelligence robotics company based in San Diego, California, focused on developing advanced AI-powered systems for national security and first responders. Incorporated in 2015, the company specializes in creating technologies that enhance the safety of military personnel and civilians. Its flagship products include Nova, an autonomous quadcopter drone equipped with lidar technology that operates effectively in GPS-denied environments, and Hivemind, an AI framework that allows various unmanned vehicles to learn from real and synthetic experiences, enabling autonomous operations without direct human control. Additionally, Shield AI has developed the V-BAT, a vertical takeoff and landing aircraft that can navigate contested environments and has been utilized in regions like the Black Sea and the Middle East. The company aims to transform defense operations by leveraging cutting-edge AI and machine learning technologies to execute complex tasks in dynamic and denied environments.

Humata is an AI research assistant that provides answers to questions asked by the user on files such as technical papers and reports. It also allows users to upload files and documents.

Rize ETF is committed to challenging orthodoxy and providing investors with seamless access to the most ground-breaking megatrends shaping the planet.

Palantir Technologies, established in 2003, specializes in developing data integration and analysis platforms. The company offers two primary products: Palantir Gotham, designed for enterprises to manage, secure, and analyze data, and Palantir Metropolis, focused on quantitative data analysis. Palantir serves a wide range of sectors, including government, defense, finance, healthcare, and others, helping them make sense of large, complex data sets. The company is headquartered in Palo Alto, California.

Archer is an aerospace company based in the San Francisco Bay Area, dedicated to advancing sustainable air mobility. The company specializes in designing, manufacturing, and operating all-electric vertical takeoff and landing aircraft aimed at enhancing urban mobility. Archer's flagship aircraft is designed to carry four passengers for up to 60 miles at speeds of up to 150 mph, with minimal noise production.

Hammerspace is a company that offers a software-defined data orchestration and storage solution designed to provide unified file access across various storage types and locations. Its core technology, the Parallel Global File System, enables organizations to treat data as a global resource, facilitating direct multi-protocol access to files regardless of the underlying storage infrastructure, whether it be on-premises, public cloud, or private cloud. This system efficiently manages metadata, ensuring that all users access the same file information without creating duplicate copies across different storage silos. By leveraging machine learning, Hammerspace virtualizes and abstracts data from the underlying infrastructure, allowing for agile file data-as-a-service capabilities that support seamless application workloads and uninterrupted operations. This innovative approach helps organizations streamline data management and enhance productivity by eliminating complexities associated with traditional storage solutions.

Mythical Games Inc. is a game technology studio founded in 2018 and based in Sherman Oaks, California, with an additional office in Seattle, Washington. The company develops blockchain-based games and aims to create a new generation of gaming experiences by enabling true ownership of digital assets, verifiable scarcity, and integrated secondary markets. Its flagship title, Blankos, is a casual multiplayer game where players can buy, trade, and sell their unique designs. Mythical Games also provides tools for content creators and brands, allowing them to customize and own game assets. By fostering a decentralized gaming ecosystem, the company brings players, developers, and content creators together, promoting personalized experiences and driving consumer adoption of distributed ledger technology through innovative gaming products.

CrowdStrike, Inc. is a leading cybersecurity company that specializes in providing advanced cloud-based security solutions. Founded in 2011 and headquartered in Irvine, California, the company offers its flagship platform, CrowdStrike Falcon, which integrates various cybersecurity functions including IT hygiene, antivirus, endpoint detection and response, managed threat hunting, and threat intelligence. This platform serves to protect critical areas of enterprise risk, including endpoints, cloud workloads, identity, and data. In addition to its core offerings, CrowdStrike provides proactive services such as incident response and M&A cyber risk assessments, as well as professional training programs to enhance cybersecurity skills. The company caters to a diverse clientele, including public sector entities, financial institutions, healthcare providers, and large corporations across the globe, with operations extending to regions such as the United Kingdom, Australia, New Zealand, Asia Pacific, and the Middle East.

Grayscale Investments, established over a decade ago, is an asset management firm specializing in cryptocurrency investments. It offers more than 25 crypto investment products, providing financial and tax advisors with familiar structures for investing in digital currencies. The company enables investors to gain exposure to cryptocurrencies like Bitcoin (BTC) through traditional investment vehicles, eliminating the challenges of direct ownership, storage, and safekeeping.

Coinbase Global, established in 2012, operates a leading cryptocurrency exchange platform in the United States. The company facilitates transactions, buying, selling, and storage of digital currencies such as Bitcoin, Ethereum, and Litecoin for both consumers and merchants. Coinbase offers a range of products including Coinbase.com, a user-friendly platform for bitcoin transactions, a global digital asset exchange, merchant tools, and custodial services. The company, headquartered in San Francisco, California, aims to provide a safe and regulation-compliant entry point into the cryptocurrency economy.

Nvidia, established in 1993, is a leading technology company specializing in the design and manufacture of graphics processing units (GPUs). Its primary business segments are GPU and Tegra Processors. The GPU segment caters to various markets, including gaming (GeForce), professional visualization (Quadro), artificial intelligence (Tesla), cloud-based gaming (GeForce NOW), and data center (DGX, EGX). The Tegra Processor segment focuses on mobile-cloud computing, AI, and edge devices, serving markets such as gaming (SHIELD), autonomous vehicles (DRIVE AGX), medical instruments (Clara AGX), and robotics (Jetson AGX). Nvidia's products are sold to a wide range of customers, including original equipment manufacturers, system builders, retailers, and automotive manufacturers, among others. The company's headquarters are in Santa Clara, California.

Leisen performs R&D of industry-leading radar technologies and products for solid protection for the safety of urban low airspace.

Adaptive Biotechnologies Corporation is a commercial-stage company focused on advancing immune-driven medicine by leveraging the biology of the adaptive immune system to enhance disease diagnosis and treatment. Established in 2009 and headquartered in Seattle, Washington, the company offers a range of products and services, including its FDA-authorized clonoSEQ diagnostic test, which is designed for the detection and monitoring of minimal residual disease in patients with specific blood cancers, such as multiple myeloma and chronic lymphocytic leukemia. In addition to clonoSEQ, Adaptive Biotechnologies provides immunoSEQ research services and kits to support scientific research and the discovery of new diagnostic signals. The company also has a pipeline of clinical products aimed at diagnosing and managing various diseases, including cancers, autoimmune disorders, and infectious diseases. It maintains strategic collaborations with notable partners such as Genentech and Microsoft to develop innovative therapies and diagnostic tests.

Burning Rock Biotech Limited specializes in developing and providing cancer therapy selection tests in the People's Republic of China. The company offers a range of next-generation sequencing-based tests applicable to various cancer types, including lung, gastrointestinal, prostate, breast, and others, using tissue and liquid biopsy samples. Its key products include OncoScreen Plus for therapy and immunotherapy guidance, LungPlasma for non-small cell lung cancer, ColonCore for gastrointestinal cancers, and HRDCore for homologous recombination deficiency testing. Burning Rock collaborates with major pharmaceutical companies like AstraZeneca and BeiGene for clinical trials and research studies, primarily through central laboratory and companion diagnostics services. Founded in 2014, the company is headquartered in Guangzhou, with a focus on providing individualized cancer treatment guidance using NGS and biomedical informatics.

Hyperfine is a medical device company that developed Swoop, the first FDA-cleared point-of-care MRI system designed to enhance patient access to diagnostic imaging. Swoop operates at a lower magnetic field strength than traditional MRI machines, producing high-quality images quickly and efficiently. This portable system can be easily wheeled to a patient's bedside, plugged into a standard electrical outlet, and operated via an iPad, making it suitable for various clinical environments such as emergency departments and intensive care units. Hyperfine generates revenue through the sale of MRI devices and service sales, which include subscriptions for bundled devices, maintenance, and software. By providing rapid imaging capabilities at a fraction of the cost of conventional MRIs, Hyperfine aims to facilitate timely diagnoses and treatments for patients, regardless of their location or resources.

Mynaric AG specializes in laser communication solutions for high data rate and long-distance wireless data transmission between moving objects. Founded in 2009 and headquartered in Gilching, Germany, the company develops a range of products including air-to-ground, air-to-air, and space terminals, as well as optical ground stations. These systems are essential for aerospace communication networks, enabling ultra-high data rates and secure connectivity for applications across terrestrial, airborne, and space environments. Mynaric operates in two primary segments: Air, which includes HAWK terminals, and Space, featuring CONDOR terminals. Its innovative technology supports a variety of applications such as satellite constellations and high-altitude networks, positioning the company at the forefront of the communication equipment sector. Additional locations in Los Angeles and Washington, D.C. expand its operational reach.

Nextdoor, Inc. is a social networking platform based in San Francisco that facilitates local conversations among residents. Founded in 2007, the company aims to foster connections within neighborhoods by allowing users to share recommendations, news updates, and resources while also promoting local businesses and services. Nextdoor enhances community engagement by offering features like the Help Map, which enables neighbors to offer assistance to those in need, particularly during crises such as the Covid-19 pandemic. With a presence in multiple countries, including the United States, the United Kingdom, and several European nations, Nextdoor seeks to create a sense of belonging and support among neighbors, emphasizing the importance of community in people's lives.

Zoom is a software company that offers a communications platform that connects people through video, voice, chat, and content sharing. It has an easy, reliable cloud platform for video and audio conferencing, collaboration, chat, and webinars across mobile devices, desktops, telephones, and room systems.

Palantir Technologies, established in 2003, specializes in developing data integration and analysis platforms. The company offers two primary products: Palantir Gotham, designed for enterprises to manage, secure, and analyze data, and Palantir Metropolis, focused on quantitative data analysis. Palantir serves a wide range of sectors, including government, defense, finance, healthcare, and others, helping them make sense of large, complex data sets. The company is headquartered in Palo Alto, California.

NearPad is a software development company. They offer to help developers deliver innovations at scale while enabling users to experience developments that scale within their needs. Their platform focuses on blockchain, gaming, art, and DeFi.

Quantum-Si is focused on revolutionizing the growing field of proteomics. The company’s suite of technologies are powered by a first-of-its-kind semiconductor chip designed to enable single-molecule next-generation protein sequencing and genomics, and digitize proteomic research in order to advance drug discovery and diagnostics beyond what has been possible with DNA sequencing.

InterCure Ltd. is a medical device company that specializes in the development of innovative technologies for the treatment of cardiovascular and pulmonary diseases. Founded in 1994 and based in Hadera, Israel, InterCure has created a patented technology platform known as "Interactive Respiratory-Pacing." This platform has led to the development of product lines that offer non-drug treatments for prevalent conditions such as hypertension and heart failure. The company's flagship product, RESPeRATE, is the only FDA-cleared medical device shown to effectively reduce high blood pressure without side effects. Additionally, InterCure's heart failure treatment, InTone™, has successfully completed phase 2a clinical trials and is awaiting regulatory approval for market launch. With a strong management team and an esteemed Scientific Advisory Board, InterCure aims to lead the market in patient-focused medical devices that address significant health challenges without reliance on pharmaceuticals.

Evogene Ltd. is a computational biology company headquartered in Rehovot, Israel, focused on the discovery and development of life-science products across various industries, including agriculture, human health, and industrial applications. Utilizing its Computational Predictive Biology (CPB) platform, Evogene combines deep biological insights with big data and artificial intelligence to enhance product development efficiency and efficacy. The Agriculture segment works on seed traits and ag-chemical products aimed at improving crop performance for species such as corn, soybean, and cotton. In the Human Health sector, the company develops microbiome-based therapeutics targeting immuno-oncology and gastrointestinal disorders, along with medical cannabis products. The Industrial Applications segment concentrates on enhancing castor bean seeds for biofuel production. Evogene operates globally, with a presence in the United States, Israel, and Brazil, and maintains strategic collaborations and licensing agreements with major agricultural firms. Founded in 1999, the company leverages advanced technologies to transform life-science product development processes.