Codon Capital

Codon Capital is a venture capital firm established in 2013 and located in San Francisco, California. The firm specializes in investing in biotechnology companies, particularly in the fields of Therapeutics and Synthetic Biology. It aims to connect entrepreneurs and researchers to explore strategies for transforming innovative ideas into viable products and startup enterprises. By concentrating on these two key areas of biology, Codon Capital seeks to leverage the potential of the new biology design revolution, which is poised to significantly impact healthcare and agriculture.

Karl Handelsman

Managing Partner

7 past transactions

Seismic Therapeutic

Series B in 2023
Seismic Therapeutic is a biotechnology company focused on advancing immunology drug development through the integration of machine learning in the biologics discovery process. Utilizing its proprietary IMPACTâ„¢ platform, Seismic Therapeutic addresses critical challenges in the development of biologics by combining machine learning with structural biology, protein engineering, and translational immunology. This innovative approach aims to create optimized therapies for patients more efficiently. The company is developing a pipeline of biologics specifically targeting adaptive immune system dysregulation to treat various autoimmune diseases.

AIRNA

Series A in 2023
AIRNA is a biotechnology company specializing in the development of RNA editing therapies. Its platform enables the creation of therapeutics designed to treat both rare and common diseases, with the goal of improving patients' health.

EpiBiologics

Series A in 2023
EpiBiologics is a biotechnology company focused on developing antibody-based targeted therapies aimed at membrane and extracellular proteins that contribute to various diseases. Utilizing its proprietary EpiTAC platform, EpiBiologics creates therapeutics designed to degrade these disease-driving proteins, addressing the underlying biology of a wide range of disorders. The company's innovative approach enables researchers to manipulate cellular proteostasis, offering potential advancements in the treatment of challenging health conditions.

Bonum Therapeutics

Series A in 2022
Bonum Therapeutics is a biotechnology company focused on developing protein-based drugs aimed at treating various diseases, with a primary emphasis on cancer. The company has established a technology platform that enables the creation of drugs capable of sensing their local environment and transitioning from an inactive to an active form. This innovative approach allows for the development of therapeutics that can be tailored to respond to specific conditions, thereby enhancing the potential for effective treatment of diseases that currently lack viable cures. In addition to cancer, Bonum Therapeutics also targets metabolic diseases, immunological disorders, and pain management.

Ansa Biotechnologies

Series A in 2022
Founded in 2018, Ansa Biotechnologies develops an innovative DNA synthesis technology based on enzymes. This novel approach aims to accelerate biological research and engineering by producing gene-length oligonucleotides more efficiently than traditional chemical methods.

Good Therapeutics

Series A in 2020
Good Therapeutics, Inc. is a biotechnology company based in Seattle, Washington, founded in 2016. The company specializes in developing innovative biotherapeutics and self-regulating drugs that provide therapeutic activity in a context-dependent manner. Their core technology involves designing allosterically-regulated proteins that can detect specific biomarkers and respond accordingly, activating therapeutic functions only when and where needed. This approach aims to enhance drug safety and efficacy by reducing systemic toxicity while maintaining therapeutic effectiveness. Currently, Good Therapeutics is primarily focused on applications within immuno-oncology, aiming to create safer and more effective treatment options that optimize patient outcomes.

Pivot Bio

Series C in 2020
Founded in 2010, Pivot Bio is a biotechnology company specializing in microbial nitrogen fertilizers. It harnesses naturally occurring microbes to provide nutrients to crops sustainably, aiming to reduce the need for petrochemical fertilizers and improve crop yield.
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