Johnson & Johnson Innovation - JJDC

TECLens, LLC is a development stage company based in St. James, New York, focused on designing and manufacturing medical contact lenses for myopia treatment. Established in 2013, the company has developed a non-invasive therapy involving the use of its product, the CXLens (Corneal Crosslinking Lens), which is worn for just half an hour in a doctor's office. This innovative lens features real-time ultrasound sensing and a high oxygen concentration environment to ensure precise targeting and stability during treatment. TECLens aims to address various vision issues, including progressive myopia in children and vision problems in adults, such as hyperopia and low-order myopia. Its technology is designed to improve patients' eye health and potentially reduce the long-term risks associated with traditional corrective lenses.

Cala Health, Inc. is a bioelectronic medicine company based in Burlingame, California, founded in 2013. It specializes in developing wearable neuromodulation therapies aimed at treating chronic diseases. The company's flagship product, Cala Trio, is a non-invasive prescription therapy designed to provide transient relief from hand tremors in adults with essential tremor. By integrating advancements in neuroscience and technology, Cala Health focuses on delivering individualized peripheral nerve stimulation. In addition to its work on essential tremor, the company is also developing therapies for other neurological conditions, including Parkinson's disease, as well as applications in psychiatry, cardiology, and autoimmune disorders.

G.I. Windows, Inc. is a clinical-stage company based in West Bridgewater, Massachusetts, specializing in the manufacture of medical devices that utilize surgical anastomotic technology. Founded in 2012, the company aims to revolutionize surgical procedures by developing less invasive techniques for treating obesity and type 2 diabetes. G.I. Windows is focused on creating innovative solutions that not only enhance patient outcomes but also contribute to cost reduction in the healthcare system. Through its commitment to advancing surgical technology, the company seeks to establish a new category in healthcare, enabling the development of procedures that are novel and less invasive.

Spectrawave, Inc. is a medical device company based in Waltham, Massachusetts, founded in 2017. The company specializes in developing and manufacturing optical diagnostic and therapeutic devices aimed at enhancing the diagnosis and treatment of cardiovascular diseases. One of its key innovations is a spectroscopy catheter that integrates advanced imaging technologies to improve outcomes for patients with coronary artery disease (CAD). This cutting-edge imaging system provides interventional cardiologists with crucial optical and computational insights, enabling them to identify patients and plaque formations that may pose risks for future coronary complications. Through its focus on photonics, Spectrawave aims to optimize stent interventions and improve overall patient care in the field of cardiovascular medicine.

HistoSonics, Inc. is a medical technology company based in Plymouth, Minnesota, specializing in non-invasive tumor ablation systems. The company has developed the Edison Platform, which employs advanced imaging and proprietary sensing technology to deliver precise sonic beam therapy. This innovative platform utilizes histotripsy and focused sound energy to liquefy and destroy targeted tissues at the sub-cellular level, enabling personalized treatments. HistoSonics' technology allows physicians to monitor the treatment in real time, offering a safe alternative to traditional interventional and surgical methods, minimizing undesirable side effects often associated with these approaches. Incorporated in 2009, HistoSonics aims to enhance treatment outcomes through its pioneering non-invasive solutions.

Loci Orthopaedics Limited, based in Upper Newcastle, Ireland, specializes in developing innovative medical technologies to address significant unmet clinical needs in orthopedics. Founded in 2017, the company focuses on creating surgical implants, particularly the InDx implant, which is designed to treat arthritis in the thumb base joint. This implant uniquely mimics the natural motions of the thumb joint, offering a less invasive and easier insertion method compared to existing surgical options. Additionally, Loci Orthopaedics is known for its Osteoanchor surface architecture, which is based on evidence-based designs, enabling clinicians to effectively address challenges in orthopedic extremities.

Asceneuron SA is a biotechnology company based in Lausanne, Switzerland, founded in 2012, that focuses on discovering and developing therapeutics for neurodegenerative disorders with significant unmet medical needs. The company targets conditions such as progressive supranuclear palsy, orphan tauopathies, Alzheimer’s disease, and Parkinson’s disease. Asceneuron aims to develop orally bioavailable small molecule drugs that address both symptomatic relief and disease progression for these debilitating conditions. Tauopathies, characterized by the accumulation of tau protein deposits in the brain, are a key area of focus, as they currently lack effective treatments. With the increasing prevalence of Alzheimer's disease posing a major healthcare challenge, Asceneuron aspires to become a leading entity in the biotech sector by providing innovative and more effective therapeutic options for patients suffering from neurodegenerative diseases. The company operates as a subsidiary of Merck KGaA.

Astraveus is transforming cell and gene therapy (CGT) manufacturing through its Lakhesys™ platform, an innovative cell foundry that leverages deep process optimization and microfluidic bioprocessors. This technology allows for the production of personalized biological therapies with minimal infrastructure requirements, ultimately reducing costs and addressing logistical challenges in the industry. By automating autologous bioproduction, the platform enhances the efficiency of transforming cells into therapeutic agents, enabling healthcare providers to scale the development and manufacturing of CGT solutions. Astraveus aims to improve patient access to these vital therapies while minimizing environmental impact.

Solenic Medical, Inc. is a medical device company founded in 2019 and based in College Station, Texas. It specializes in developing a non-invasive treatment for infected metallic implants using a technology that employs alternating magnetic fields generated by external coils. This innovative approach targets biofilm on the surfaces of medical implants, which is a significant complication in surgeries like knee and hip replacements, as well as in trauma-related procedures involving plates and rods. The technology has the potential to replace the costly and risky two-step revision surgical procedure currently used to address chronic infections in medical implants, thereby offering a safer and more effective solution for patients.

HistoSonics, Inc. is a medical technology company based in Plymouth, Minnesota, specializing in non-invasive tumor ablation systems. The company has developed the Edison Platform, which employs advanced imaging and proprietary sensing technology to deliver precise sonic beam therapy. This innovative platform utilizes histotripsy and focused sound energy to liquefy and destroy targeted tissues at the sub-cellular level, enabling personalized treatments. HistoSonics' technology allows physicians to monitor the treatment in real time, offering a safe alternative to traditional interventional and surgical methods, minimizing undesirable side effects often associated with these approaches. Incorporated in 2009, HistoSonics aims to enhance treatment outcomes through its pioneering non-invasive solutions.

DocSpera is an integrated surgical coordination platform that enhances workflow efficiencies and patient care by streamlining synchronization across various sites and teams. Its proprietary technology automates pre-surgical coordination and facilitates real-time, secure case and image synchronization among surgeons, care teams, and device suppliers, utilizing electronic health record (EHR) data. The platform also provides real-time patient insights and operating room dashboards, enabling continuous monitoring of patients from the surgical decision point through recovery. Headquartered in Sunnyvale, California, DocSpera operates under Compliant Innovations Inc.

V-Wave Ltd. is a private company that develops percutaneous implantable therapeutic devices for patients suffering from chronic heart failure. Founded in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave has created a proprietary interatrial shunt designed to alleviate symptoms associated with both preserved and reduced ejection fraction heart failure. This biocompatible implant regulates left atrial pressure, addressing a key factor in the deterioration of heart failure. The device aims to enhance patients' quality of life by reducing hospitalizations and improving exercise capacity. V-Wave's team consists of experienced engineers and medical scientists dedicated to advancing treatment options for individuals who continue to experience debilitating symptoms despite optimal medical care.

Mauna Kea Technologies, established in 2000 and based in Paris, France, specializes in developing and marketing medical devices for cancer and other disease diagnosis and treatment. Its core product, Cellvizio, is a real-time, cellular-level imaging platform used by physicians and researchers worldwide. This platform, based on confocal laser endomicroscopy, enables precise, in vivo visualization of tissues during standard procedures, aiding in early-stage pathology detection and informed therapeutic decisions. The company generates revenue through the sale of Cellvizio products and accessories, serving customers in Europe, the Middle East, Africa, the Americas, and Asia.

FlexDex Inc. is a company focused on developing minimally invasive surgery (MIS) devices. Its innovative platform technology allows for the translation of a surgeon's hand, wrist, and arm movements from outside the patient into precise movements of an end-effector inside the body, thereby enhancing the functionality of MIS instruments and endoscopes. The company collaborates with distributors to serve healthcare professionals both in the United States and internationally. Founded in 2010 and based in Brighton, Michigan, FlexDex aims to improve surgical outcomes through its advanced medical device technology.

Thirty Madison, Inc. is a digital health company based in Astoria, New York, that focuses on providing specialized healthcare solutions for patients with chronic conditions. Founded in 2016, the company operates several condition-specific brands, including Keeps, which offers a subscription-based service for men’s hair loss prevention; Cove, which provides online consultations and prescriptions for migraine treatment; Picnic, targeting allergies; Facet for skin conditions; and NURX for sexual health. Each brand is designed to address the unique needs of its community, offering personalized treatments and support. Thirty Madison emphasizes a human-centered approach, empowering individuals with accessible and effective healthcare solutions tailored to their ongoing conditions.

Cue Health Inc. is a healthcare technology company based in San Diego, California, specializing in the development and manufacturing of diagnostic screening devices for home use. Founded in 2010, the company offers a connected diagnostic platform known as the Cue Health Monitoring System, which allows users to conduct self-serve tests that provide lab-quality results. This platform enables individuals to track key health indicators, including inflammation, vitamin D, fertility, influenza, and testosterone, through a user-friendly device that connects to a smartphone app. The Cue app not only displays test results but also integrates data on lifestyle factors such as activity and sleep, facilitating a comprehensive view of health at a molecular level. Additionally, Cue Health provides various services for healthcare professionals, including tools for managing patient test histories and telemedicine consultations. The company's innovative approach empowers consumers and healthcare providers alike to access critical health information easily and effectively.

TechsoMed is an Israeli medical device company focused on developing ultrasound-based real-time monitoring systems specifically for thermal ablation procedures. This technology addresses the high failure rates associated with these minimally invasive treatments, which are used in various applications, including tumor destruction, heart arrhythmia management, and blood pressure regulation. By providing real-time monitoring and control of tissue destruction, TechsoMed's system enhances the effectiveness of ablation procedures, offering significant benefits to patients, physicians, and insurance companies. The integration of their imaging and analysis unit with standard ultrasound devices allows physicians to better predict the progression of tissue destruction, thereby improving treatment outcomes in a market that has significant growth potential.

Paige, founded in 2017 by Thomas Fuchs and colleagues from Memorial Sloan Kettering Cancer Center, specializes in computational pathology products that enhance cancer diagnostics. The company has developed a platform utilizing advanced deep learning algorithms to improve diagnostic stratification and cancer detection, particularly for breast and prostate cancers. This innovative technology aims to empower patients and their care teams to make informed treatment decisions by providing pathologists with critical insights for more accurate diagnoses. Paige's user-friendly platform minimizes the burden on IT resources while ensuring patient safety and data privacy. As a pioneer in the field, Paige has achieved FDA breakthrough designation for its computational pathology products, positioning itself at the forefront of transforming pathology workflows and increasing diagnostic confidence.

V-Wave Ltd. is a private company that develops percutaneous implantable therapeutic devices for patients suffering from chronic heart failure. Founded in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave has created a proprietary interatrial shunt designed to alleviate symptoms associated with both preserved and reduced ejection fraction heart failure. This biocompatible implant regulates left atrial pressure, addressing a key factor in the deterioration of heart failure. The device aims to enhance patients' quality of life by reducing hospitalizations and improving exercise capacity. V-Wave's team consists of experienced engineers and medical scientists dedicated to advancing treatment options for individuals who continue to experience debilitating symptoms despite optimal medical care.

G.I. Windows, Inc. is a clinical-stage company based in West Bridgewater, Massachusetts, specializing in the manufacture of medical devices that utilize surgical anastomotic technology. Founded in 2012, the company aims to revolutionize surgical procedures by developing less invasive techniques for treating obesity and type 2 diabetes. G.I. Windows is focused on creating innovative solutions that not only enhance patient outcomes but also contribute to cost reduction in the healthcare system. Through its commitment to advancing surgical technology, the company seeks to establish a new category in healthcare, enabling the development of procedures that are novel and less invasive.

Thirty Madison, Inc. is a digital health company based in Astoria, New York, that focuses on providing specialized healthcare solutions for patients with chronic conditions. Founded in 2016, the company operates several condition-specific brands, including Keeps, which offers a subscription-based service for men’s hair loss prevention; Cove, which provides online consultations and prescriptions for migraine treatment; Picnic, targeting allergies; Facet for skin conditions; and NURX for sexual health. Each brand is designed to address the unique needs of its community, offering personalized treatments and support. Thirty Madison emphasizes a human-centered approach, empowering individuals with accessible and effective healthcare solutions tailored to their ongoing conditions.

Cue Health Inc. is a healthcare technology company based in San Diego, California, specializing in the development and manufacturing of diagnostic screening devices for home use. Founded in 2010, the company offers a connected diagnostic platform known as the Cue Health Monitoring System, which allows users to conduct self-serve tests that provide lab-quality results. This platform enables individuals to track key health indicators, including inflammation, vitamin D, fertility, influenza, and testosterone, through a user-friendly device that connects to a smartphone app. The Cue app not only displays test results but also integrates data on lifestyle factors such as activity and sleep, facilitating a comprehensive view of health at a molecular level. Additionally, Cue Health provides various services for healthcare professionals, including tools for managing patient test histories and telemedicine consultations. The company's innovative approach empowers consumers and healthcare providers alike to access critical health information easily and effectively.

HistoSonics, Inc. is a medical technology company based in Plymouth, Minnesota, specializing in non-invasive tumor ablation systems. The company has developed the Edison Platform, which employs advanced imaging and proprietary sensing technology to deliver precise sonic beam therapy. This innovative platform utilizes histotripsy and focused sound energy to liquefy and destroy targeted tissues at the sub-cellular level, enabling personalized treatments. HistoSonics' technology allows physicians to monitor the treatment in real time, offering a safe alternative to traditional interventional and surgical methods, minimizing undesirable side effects often associated with these approaches. Incorporated in 2009, HistoSonics aims to enhance treatment outcomes through its pioneering non-invasive solutions.

GATT Technologies BV, established in 2011 and headquartered in Nijmegen, the Netherlands, specializes in developing innovative medical devices. The company focuses on creating synthetic surgical hemostat and sealant products designed to control severe bleeding and organ leakages during surgical procedures. Their product portfolio includes GATT-Patch, a hemostatic sealing patch for general surgery; GATT-Tape, an adhesive tape for preventing intestinal anastomotic leakage; GATT-Spray, an elastic sealant for general surgery; and GATT-Powder, a hemostatic sealing powder. These products are based on a patented synthetic technology, aiming to address challenging surgical bleeding and leakage issues.

OrthoSpin Limited, founded in 2014 and based in Misgav, Israel, specializes in the development of an innovative robotic external fixation system designed to enhance treatment for patients with bone injuries and limb deformities. The company’s dynamic external fixators offer a significant improvement over traditional systems, which are often cumbersome and painful. OrthoSpin’s system features a lightweight motorized strut and a control box integrated into a circular hexapod fixation frame, allowing for automatic and continuous pre-programmed adjustments without requiring patient involvement. This smart system not only ensures adherence to prescribed treatment plans but also enables real-time monitoring of patient progress through proprietary software. By facilitating timely adjustments to treatment schedules, OrthoSpin aims to reduce complications and improve clinical outcomes for orthopedic patients, thereby accelerating their recovery process.

Mauna Kea Technologies, established in 2000 and based in Paris, France, specializes in developing and marketing medical devices for cancer and other disease diagnosis and treatment. Its core product, Cellvizio, is a real-time, cellular-level imaging platform used by physicians and researchers worldwide. This platform, based on confocal laser endomicroscopy, enables precise, in vivo visualization of tissues during standard procedures, aiding in early-stage pathology detection and informed therapeutic decisions. The company generates revenue through the sale of Cellvizio products and accessories, serving customers in Europe, the Middle East, Africa, the Americas, and Asia.

TechsoMed is an Israeli medical device company focused on developing ultrasound-based real-time monitoring systems specifically for thermal ablation procedures. This technology addresses the high failure rates associated with these minimally invasive treatments, which are used in various applications, including tumor destruction, heart arrhythmia management, and blood pressure regulation. By providing real-time monitoring and control of tissue destruction, TechsoMed's system enhances the effectiveness of ablation procedures, offering significant benefits to patients, physicians, and insurance companies. The integration of their imaging and analysis unit with standard ultrasound devices allows physicians to better predict the progression of tissue destruction, thereby improving treatment outcomes in a market that has significant growth potential.

Cala Health, Inc. is a bioelectronic medicine company based in Burlingame, California, founded in 2013. It specializes in developing wearable neuromodulation therapies aimed at treating chronic diseases. The company's flagship product, Cala Trio, is a non-invasive prescription therapy designed to provide transient relief from hand tremors in adults with essential tremor. By integrating advancements in neuroscience and technology, Cala Health focuses on delivering individualized peripheral nerve stimulation. In addition to its work on essential tremor, the company is also developing therapies for other neurological conditions, including Parkinson's disease, as well as applications in psychiatry, cardiology, and autoimmune disorders.

OrthoSpin Limited, founded in 2014 and based in Misgav, Israel, specializes in the development of an innovative robotic external fixation system designed to enhance treatment for patients with bone injuries and limb deformities. The company’s dynamic external fixators offer a significant improvement over traditional systems, which are often cumbersome and painful. OrthoSpin’s system features a lightweight motorized strut and a control box integrated into a circular hexapod fixation frame, allowing for automatic and continuous pre-programmed adjustments without requiring patient involvement. This smart system not only ensures adherence to prescribed treatment plans but also enables real-time monitoring of patient progress through proprietary software. By facilitating timely adjustments to treatment schedules, OrthoSpin aims to reduce complications and improve clinical outcomes for orthopedic patients, thereby accelerating their recovery process.

Zebra Medical Vision Ltd. is a company that develops an imaging analytics platform aimed at enhancing patient care in healthcare institutions. Founded in 2014 and based in Shefayim, Israel, the platform utilizes advanced learning and computer vision algorithms to assist clinicians in identifying patients at risk of various diseases. This technology supports healthcare providers in implementing effective risk management and preventative care strategies. Zebra Medical Vision also supplies tools and datasets for machine-learning researchers, facilitating the rapid development of decision support tools and diagnostic solutions. The company has established strategic partnerships with organizations such as USARAD Holdings and TELUS Ventures, and has secured a total of $52 million in funding from notable investors, including Khosla Ventures and Nvidia. Its AI-driven products are FDA cleared and are utilized in hospitals across multiple regions, including the U.S., Europe, Australia, India, and Latin America, positioning Zebra Medical Vision as a leader in the field of medical imaging and analytics.

Cala Health, Inc. is a bioelectronic medicine company based in Burlingame, California, founded in 2013. It specializes in developing wearable neuromodulation therapies aimed at treating chronic diseases. The company's flagship product, Cala Trio, is a non-invasive prescription therapy designed to provide transient relief from hand tremors in adults with essential tremor. By integrating advancements in neuroscience and technology, Cala Health focuses on delivering individualized peripheral nerve stimulation. In addition to its work on essential tremor, the company is also developing therapies for other neurological conditions, including Parkinson's disease, as well as applications in psychiatry, cardiology, and autoimmune disorders.