E12 Ventures

Founded in 2018, First Resonance develops a manufacturing software platform designed for modern manufacturers. Its factory operating system accelerates manufacturing processes, tracks parts and processes from prototype to full-scale production, and provides real-time insights into manufacturing process bottlenecks.

one.bio is a biotechnology company spun out from UC Davis that develops naturally derived oligosaccharides using proprietary technology to convert natural products into novel ingredients. The focus is on producing oligosaccharides that modulate the microbiome and immune function for applications in food, agriculture, and biopharmaceuticals. By supplying clients with novel prebiotics, symbiotics, and immunomodulatory ingredients, the company aims to support health outcomes in humans and animals. Leveraging its specialized platform, one.bio pursues ingredients that can influence gut microbiota, nutrient absorption, and immune responses, positioning itself at the intersection of nutrition and therapeutics.

Unspun, Inc. is a digital apparel company based in San Francisco, California, founded in 2015. It specializes in creating custom jeans tailored to individual consumers using advanced body scanning technology, fit algorithms, and additive manufacturing. The company aims to address environmental challenges by minimizing pattern-cutting waste and unsold inventory, thus contributing to a reduction in global carbon emissions. Unspun's innovative approach enables on-demand production of jeans in under ten minutes, utilizing localized manufacturing processes designed to be zero-waste. Its technology has gained recognition, including being named one of TIME's Best Inventions of 2019, and supports a B2B platform that facilitates digital customization for major apparel brands.

Ciba Health is a personalized digital therapeutics and virtual care platform that focuses on treating and reversing chronic conditions through a precision health approach. The company empowers patients by promoting self-care and offering a patient-centered, root-cause methodology. Ciba Health emphasizes a value-based care delivery model that integrates full-spectrum care, providing convenient access to multidisciplinary teams. By leveraging advanced technology, it implements individualized treatment plans that address the physical, mental, and lifestyle needs of patients, fostering improvements in overall well-being.