Two River Group

Two River Group, founded in 2004 and based in New York, is a venture capital firm focused on the life sciences and healthcare sectors. The company partners with experienced management teams to create, finance, and operate development-stage companies aimed at improving health outcomes and quality of life. Two River Group specializes in investing in firms with strong intellectual property and proven leadership, particularly those that have successfully developed innovative technologies. The firm's expertise encompasses a range of areas, including oncology, cardiovascular disease, ophthalmology, neurological disorders, and animal health. Two River Group is dedicated to fostering close collaborations with its portfolio companies, assisting them in product development, regulatory strategy, corporate strategy, and daily operations to ensure mutual success.

Arie Belldegrun

Chairman and Partner

Joshua Kazam

Co-Founder and Partner

23 past transactions

Candid Therapeutics

Series A in 2024
Candid Therapeutics is a biotechnology company that focuses on the treatment of a range of immunological conditions.

ByHeart

Venture Round in 2024
ByHeart operates as a fully integrated infant nutrition company. It is dedicated to translating leading nutrition science and breastmilk research into evolved foods and formulas to support babies’ health and parents’ peace of mind. Its products strive to be next to nature made from hand-picked ingredients using small-batch blending and sit at the forefront of immune, microbiome, cognitive, and digestive health. The company was founded in 2016 and is headquartered in New York.

ByHeart

Series B in 2021
ByHeart operates as a fully integrated infant nutrition company. It is dedicated to translating leading nutrition science and breastmilk research into evolved foods and formulas to support babies’ health and parents’ peace of mind. Its products strive to be next to nature made from hand-picked ingredients using small-batch blending and sit at the forefront of immune, microbiome, cognitive, and digestive health. The company was founded in 2016 and is headquartered in New York.

IconOVir Bio

Series A in 2021
IconOVir Bio is a preclinical-stage biotechnology company focused on developing innovative oncolytic virus therapies for cancer treatment. The company's proprietary platform aims to overcome the limitations associated with first- and second-generation oncolytic viruses, thereby enhancing the therapeutic options available to healthcare professionals. By prioritizing personalized therapy, IconOVir Bio seeks to improve treatment outcomes for cancer patients, positioning itself at the forefront of advancements in oncology.

Neogene Therapeutics

Series A in 2020
Neogene Therapeutics, Inc. is a biotechnology company based in New York, founded in 2018, that focuses on developing T cell therapies for cancer treatment. The company specializes in creating personalized engineered T cells that target neo-antigens, which are mutated proteins present in cancer cells due to DNA mutations. By leveraging advanced technologies, Neogene isolates T cell receptor (TCR) genes specific to these neo-antigens from tumor biopsies routinely collected from patients. This process utilizes high-sensitivity DNA sequencing and genetic screening to identify TCRs that can effectively recognize and attack cancer cells. Neogene's innovative approach aims to enhance the precision and efficacy of cancer therapies, offering improved treatment options for patients facing a broad spectrum of cancers.

ByHeart

Series A in 2020
ByHeart operates as a fully integrated infant nutrition company. It is dedicated to translating leading nutrition science and breastmilk research into evolved foods and formulas to support babies’ health and parents’ peace of mind. Its products strive to be next to nature made from hand-picked ingredients using small-batch blending and sit at the forefront of immune, microbiome, cognitive, and digestive health. The company was founded in 2016 and is headquartered in New York.

Kronos Bio

Series A in 2019
Kronos Bio, Inc. is a clinical-stage biopharmaceutical company dedicated to discovering and developing innovative cancer therapeutics. Founded in 2017 and headquartered in San Mateo, California, the company focuses on targeting dysregulated transcription factors and oncogenic signaling pathways. Its lead candidate, entospletinib, is a selective inhibitor of spleen tyrosine kinase aimed at treating acute myeloid leukemia. Additionally, Kronos Bio is developing KB-0742, an orally bioavailable inhibitor of cyclin-dependent kinase 9, intended for MYC-amplified solid tumors. By leveraging advanced technologies such as high-throughput small-molecule microarrays and targeted protein degradation, Kronos Bio aims to identify effective compounds that can modulate historically undruggable cancer targets, ultimately striving to improve patient outcomes through precision medicine.

Keeps

Series A in 2018
2 out of 3 men will start to lose their hair by the age of 35 - but the earlier you take action, the more hair you keep. Keeps is a full-service healthcare company focused exclusively on helping men keep their hair. From expert diagnosis to affordable treatment, patient support to education, Keeps provides a regimen specific to each customer's condition through a seamless digital experience, allowing men to manage hair loss from start to finish. Keeps’ licensed physicians review each customer's information in order to identify and prescribe a unique treatment plan of FDA-approved products, and we sell them at half the price customers would pay at their local pharmacy. With Keeps, customers receive exactly what they need, and nothing they don’t. Keeps is the first brand from Thirty Madison, which is rebuilding the healthcare experience for the modern consumer.

Thirty Madison

Series A in 2018
Thirty Madison, Inc. is a digital health company based in Astoria, New York, that operates web-based platforms tailored to patients with chronic conditions. Founded in 2016, the company offers a range of specialized healthcare brands, including Keeps for men’s hair loss, Cove for migraines, Picnic for allergies, Facet for skin conditions, and NURX for sexual health. Each brand is designed to provide personalized treatments and care, addressing the unique needs of its community. By focusing on specific ongoing conditions, Thirty Madison seeks to empower individuals through accessible and effective healthcare solutions, facilitating exceptional outcomes for patients over a lifetime of care.

Willow

Seed Round in 2018
Willow is stylish affordable disposable underwear that offers comfort, confidence, and leak-free protection, delivered discreetly to your door at a fraction of the price. Current options on the market are either expensive or bulky and generally lacking in style — plus, you have to purchase them at the store. Willow’s product is the thinnest and most absorbent on the market, and has better odor control than other products. It’s extremely "breathable” and wicks liquid away from skin, just like sportswear. Best of all, Willow’s stylish products cost less than others because they are sold directly to the consumer, with no mark up by stores.

HUBBLE

Venture Round in 2018
See, Easy. We believe buying contact lenses and glasses should be simple. Full stop. That’s why our goal is to deliver the easiest, most hassle-free contact lens and glasses experience in the world. Here’s how we see it at Hubble Contacts. If you’re spending all your time arguing with customer service reps, endlessly searching for the right pair of glasses, or trying to remember to reorder your contacts before they run out (again), you’re not focused on all the things the world has to offer. Like that incredible sunset outside your window, the text convos on your phone that make you laugh (until you cry), or the gummy, toothless grin smiling at you from across her highchair. Hubble Contacts was created out of the desire to make contact lenses accessible and affordable to as many people as possible. Over the years, we have continued to evolve and adapt to the changing needs of our customers, and expand our product line along the way to also include high quality eyeglasses and sunglasses. With a passion for eye care and a dedication to customer service, our mission remains making a difference in the industry. So, let Hubble’s world-class team take care of you — and your contacts and glasses. And you? You keep your eyes on the prize.

Allogene Therapeutics

Series A in 2018
Allogene Therapeutics is a clinical stage immuno-oncology company. It is mainly engaged in the development and commercialization of genetically engineered allogeneic T cell therapies for the treatment of cancer. The company is involved in developing a pipeline of multiple allogeneic T cell product candidates utilizing validated gene editing and advanced proprietary cell manufacturing technologies. Its pipeline includes UCART19 which is developed for the treatment of relapsed or refractory acute lymphoblastic leukemia (ALL), as well as several preclinical allogeneic CAR T therapies.

Andie

Seed Round in 2018
Andie Co. is an online retailer specializing in women's swimwear, founded in 2016 and based in New York, New York. The company designs and manufactures a range of products, including one-piece and two-piece swimsuits, as well as accessories and gift cards. By operating as a direct-to-consumer brand, Andie eliminates retail middlemen, allowing women to purchase designer-quality swimwear at accessible prices. The eCommerce platform enables customers to try on swimsuits at home, ensuring they can find the right fit. With a focus on high-design and luxurious materials, Andie aims to provide a compelling alternative to traditional options in the swimwear market, catering to women's needs for both style and affordability.

HUBBLE

Series A in 2017
See, Easy. We believe buying contact lenses and glasses should be simple. Full stop. That’s why our goal is to deliver the easiest, most hassle-free contact lens and glasses experience in the world. Here’s how we see it at Hubble Contacts. If you’re spending all your time arguing with customer service reps, endlessly searching for the right pair of glasses, or trying to remember to reorder your contacts before they run out (again), you’re not focused on all the things the world has to offer. Like that incredible sunset outside your window, the text convos on your phone that make you laugh (until you cry), or the gummy, toothless grin smiling at you from across her highchair. Hubble Contacts was created out of the desire to make contact lenses accessible and affordable to as many people as possible. Over the years, we have continued to evolve and adapt to the changing needs of our customers, and expand our product line along the way to also include high quality eyeglasses and sunglasses. With a passion for eye care and a dedication to customer service, our mission remains making a difference in the industry. So, let Hubble’s world-class team take care of you — and your contacts and glasses. And you? You keep your eyes on the prize.

HUBBLE

Series A in 2017
See, Easy. We believe buying contact lenses and glasses should be simple. Full stop. That’s why our goal is to deliver the easiest, most hassle-free contact lens and glasses experience in the world. Here’s how we see it at Hubble Contacts. If you’re spending all your time arguing with customer service reps, endlessly searching for the right pair of glasses, or trying to remember to reorder your contacts before they run out (again), you’re not focused on all the things the world has to offer. Like that incredible sunset outside your window, the text convos on your phone that make you laugh (until you cry), or the gummy, toothless grin smiling at you from across her highchair. Hubble Contacts was created out of the desire to make contact lenses accessible and affordable to as many people as possible. Over the years, we have continued to evolve and adapt to the changing needs of our customers, and expand our product line along the way to also include high quality eyeglasses and sunglasses. With a passion for eye care and a dedication to customer service, our mission remains making a difference in the industry. So, let Hubble’s world-class team take care of you — and your contacts and glasses. And you? You keep your eyes on the prize.

HUBBLE

Seed Round in 2016
See, Easy. We believe buying contact lenses and glasses should be simple. Full stop. That’s why our goal is to deliver the easiest, most hassle-free contact lens and glasses experience in the world. Here’s how we see it at Hubble Contacts. If you’re spending all your time arguing with customer service reps, endlessly searching for the right pair of glasses, or trying to remember to reorder your contacts before they run out (again), you’re not focused on all the things the world has to offer. Like that incredible sunset outside your window, the text convos on your phone that make you laugh (until you cry), or the gummy, toothless grin smiling at you from across her highchair. Hubble Contacts was created out of the desire to make contact lenses accessible and affordable to as many people as possible. Over the years, we have continued to evolve and adapt to the changing needs of our customers, and expand our product line along the way to also include high quality eyeglasses and sunglasses. With a passion for eye care and a dedication to customer service, our mission remains making a difference in the industry. So, let Hubble’s world-class team take care of you — and your contacts and glasses. And you? You keep your eyes on the prize.

Cell Design Labs

Venture Round in 2016
Cell Design Labs, Inc. is a biotherapeutics company based in San Francisco, California, focused on developing innovative cell-based therapies for cancer and other serious diseases. Established in 2015, the company aims to harness the immune system's capabilities to create advanced treatments that offer improved power, precision, safety, and durability. Cell Design Labs specializes in disruptive T cell receptor therapies, which modify the body's immune cells to specifically recognize and eliminate malignant cells. This approach enables researchers to efficiently develop effective cell-based therapies that address some of the most challenging medical conditions. The company operates as a subsidiary of Gilead Sciences, Inc.

HUBBLE

Seed Round in 2016
See, Easy. We believe buying contact lenses and glasses should be simple. Full stop. That’s why our goal is to deliver the easiest, most hassle-free contact lens and glasses experience in the world. Here’s how we see it at Hubble Contacts. If you’re spending all your time arguing with customer service reps, endlessly searching for the right pair of glasses, or trying to remember to reorder your contacts before they run out (again), you’re not focused on all the things the world has to offer. Like that incredible sunset outside your window, the text convos on your phone that make you laugh (until you cry), or the gummy, toothless grin smiling at you from across her highchair. Hubble Contacts was created out of the desire to make contact lenses accessible and affordable to as many people as possible. Over the years, we have continued to evolve and adapt to the changing needs of our customers, and expand our product line along the way to also include high quality eyeglasses and sunglasses. With a passion for eye care and a dedication to customer service, our mission remains making a difference in the industry. So, let Hubble’s world-class team take care of you — and your contacts and glasses. And you? You keep your eyes on the prize.
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