Christopher (Chris) Alafi

Managing Partner

Moshe Alafi

General Partner

Bill Weiss

CFO

13 past transactions

Bolt Threads

Series C in 2016
Bolt is a materials company that invents and scales materials that put the planet on a path towards a better future. Biofabricated silk fibers MicrosilkTM - based on proteins found in nature, produced using Bolt Threads proprietary technology and revolutionary bioengineering concepts. Next-generation of performance fibers, fabrics and luxury products that represent cutting-edge technology in science, while raising the bar for quality, performance, and design.

Assurerx Health

Series D in 2015
Assurex Health is a personalized medicine company dedicated to helping clinicians determine the right medication for individual patients with medical conditions. Assurex Health’s proprietary Genesight® technology is based on pharmacogenomics – the study of the genetic factors that influence an individual’s response to drug treatments – as well as evidence-based medicine and clinical pharmacology.

Bolt Threads

Series B in 2015
Bolt is a materials company that invents and scales materials that put the planet on a path towards a better future. Biofabricated silk fibers MicrosilkTM - based on proteins found in nature, produced using Bolt Threads proprietary technology and revolutionary bioengineering concepts. Next-generation of performance fibers, fabrics and luxury products that represent cutting-edge technology in science, while raising the bar for quality, performance, and design.

Kreatech Diagnostics

Series B in 2010
Kreatech Holding BV is a molecular diagnostics company focused on the development and commercialization of innovative detection products. These are used for diagnostic and research applications in the life sciences and healthcare industry.

Kreatech Diagnostics

Venture Round in 2009
Kreatech Holding BV is a molecular diagnostics company focused on the development and commercialization of innovative detection products. These are used for diagnostic and research applications in the life sciences and healthcare industry.

Arcxis Biotechnologies

Series B in 2009
Arcxis Biotechnologies is focused on developing elegant, integrated and compact solutions to molecular diagnostic challenges. From proprietary microfluidics to advanced detection methods; streamlined sample preparation to comprehensive automation technology, we are in the business of making molecular methods more reliable, robust and accessible.

Natera

Series B in 2009
Natera is a diagnostic and research company specializing in genetic testing services, primarily focused on preconception and prenatal testing. Its flagship product, Panorama, is a non-invasive prenatal test that screens for chromosomal abnormalities in fetuses through a blood draw from the mother, including assessments for twin pregnancies. Other offerings include Vistara, which tests for single-gene disorders, and Horizon carrier screening to identify carrier status for various genetic diseases. Natera also provides the Anora test for analyzing fetal chromosomes in cases of miscarriage and non-invasive paternity testing. Additionally, the company has developed Signatera, a technology that detects circulating tumor DNA to monitor cancer recurrence. Natera utilizes a direct sales force and a network of approximately 100 laboratory and distribution partners for product distribution. The company was founded in 2003, has undergone several name changes, and is headquartered in San Carlos, California. Its collaborations with organizations like BGI Genomics and Foundation Medicine further enhance its capabilities in genetic testing and personalized medicine.

Isto Technologies

Series E in 2007
ISTO Technologies, Inc., an orthobiologics company, develops biologic products to regenerate and restore function to damaged cartilage and bone. It offers InQu, a resorbable bone graft extender and substitute; NuQu, a cell-based injectable therapy for disc regeneration; and DeNovo ET, an engineered cartilage implant for the repair and regeneration of knee cartilage. The company provides its products through distributors. ISTO Technologies, Inc. was founded in 1997 and is based in St. Louis, Missouri.

Stereotaxis

Venture Round in 2003
Stereotaxis focuses on the development of robotic cardiology instrument navigation systems designed to enhance the treatment of arrhythmias and coronary disease, as well as information management solutions for the interventional lab. With over 100 patents for use in a hospital's interventional surgical suite, Stereotaxis helps physicians around the world provide unsurpassed patient care with robotic precision and safety, improved lab efficiency and productivity, and enhanced collaboration of life-saving information. Stereotaxis' core technologies are the Niobe® ES Remote Magnetic Navigation system, the Odyssey™ portfolio of lab optimization, networking and patient information management systems and the Vdrive™ Robotic Mechanical Navigation system and consumables.

Leegur Oy

Venture Round in 2002
Leegur Oy develops real time adaptation software tools for mobile and fixed Internet services. The company also offers planning, implementation, and customer support services.

Direct Conversion

Venture Round in 2002
Direct Conversion AB specializes in the research, development, manufacturing, and marketing of advanced X-ray imaging sensors that utilize photon counting and hybridized semiconductor technology. Its products cater to various sectors, including dental, medical, welding, food, security, and industrial applications. The company offers a range of photon counting products under the XCounter brand, including the XC-Hydra, XC-Thor, XC-TDI, and XC-Actaeon series. Additionally, it provides charge integrating detectors under the AJAT brand, featuring models such as SNAP 225 and ARISTO. Direct Conversion also develops cadmium telluride direct conversion detectors. Founded in 1997 and headquartered in Danderyd, Sweden, the company operates additional offices in London, Espoo, and Munich. In December 2016, it changed its name from XCounter AB to Direct Conversion AB and is currently a subsidiary of Varex Imaging Corporation.

Hybrigenics

Series B in 2001
Hybrigenics Pharma is a bio-pharmaceutical company with a focus on research and development of new targets and therapies against cancer.Hybrigenics Pharma has stopped the development of inecalcitol, a vitamin D receptor agonist.Hybrigenics Pharma's research program investigates the action of enzymes called Deubiquitinating Enzymes (DUBs) in the recycling of onco-proteins and the potential activity of proprietary patented DUB inhibitors against various cancer indications.
Coley Pharmaceutical Group operates as a biopharmaceutical company developing therapeutics and drug candidates that direct the human immune system to fight cancers, asthma and allergy, autoimmune disorders, and to enhance the effectiveness of vaccines. The company was formerly known as CpG ImmunoPharmaceuticals, Inc. and in August 2000 it changed its name to Coley Pharmaceutical Group, Inc. The company was founded in 1997 and is based in Wellesley, Massachusetts. As of December 28, 2007, Coley Pharmaceutical Group, Inc. operates as a subsidiary of Pfizer Inc.
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