The Aurora Funds

The Aurora Funds, Inc., established in 1994, is a venture capital firm based in Cary, North Carolina, with an additional office in Durham. It specializes in seed and early-stage financings, typically investing in healthcare and information technology companies. Within healthcare, it focuses on biotechnology, medical devices, healthcare services, and healthcare IT. Within IT, it invests in internet infrastructure, software, data communications, semiconductors, and emerging technologies like photonics and nanotechnology. The firm prefers to be the lead or co-lead investor and aims to invest between $50,000 in seed rounds to $8 million across multiple rounds, targeting companies with enterprise values between $2 million and $40 million and EBITDA up to $75 million. It seeks board seats in its portfolio companies and is committed to providing resources to help early-stage companies reach their full potential.

Scott Albert

Co-Founder and Venture Partner

Chris Kroeger

Partner

71 past transactions

CardioFocus

Debt Financing in 2014
CardioFocus, Inc. is a biotechnology company based in Marlborough, Massachusetts, that specializes in the development of innovative medical devices for the treatment of cardiac disorders, particularly atrial fibrillation. The company offers a range of products, including the HeartLight Endoscopic Ablation System, which utilizes visually guided laser balloon technology to achieve precise pulmonary vein isolation. This system is complemented by the HeartLight Excalibur Balloon, designed for stable contact and effective lesion creation through direct tissue visualization, and the HeartLight X3 System, which allows for controlled lesion formation. CardioFocus focuses on providing electrophysiologists with advanced tools that enhance the precision and control of ablation treatments, utilizing disposable fiber optic catheters for improved visualization of cardiac anatomy and the treatment of arrhythmias. Founded in 1990, CardioFocus continues to pursue advancements in ablation technologies to better meet the needs of patients and healthcare providers.

Metabolon

Series E in 2014
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

Argos Therapeutics

Series E in 2013
Argos Therapeutics, Inc. was a biotechnology company based in Durham, North Carolina, focused on developing personalized immunotherapies for cancer, infectious diseases, and autoimmune disorders. It utilized its proprietary Arcelis technology platform to create individualized treatments, including rocapuldencel-T, which was undergoing Phase III clinical trials for metastatic renal cell carcinoma, and AGS-004, in Phase II trials for human immunodeficiency virus. The company's product pipeline also included therapies aimed at transplant rejection and autoimmune conditions. Founded in 1997 and originally named Merix Bioscience, Argos Therapeutics aimed to address significant unmet medical needs in the field of immuno-oncology. However, on September 24, 2019, the company filed for Chapter 7 bankruptcy, leading to its cessation of operations.

Regado Biosciences

Series E in 2012
Regado Biosciences is a biopharmaceutical company focused on the discovery and development of aptamer-based therapeutics, particularly those that offer antidote-controlled solutions for managing anticoagulation. Founded in 2001 and headquartered in Durham, North Carolina, the company has developed REG1, a treatment for patients with acute coronary syndrome undergoing procedures such as coronary artery bypass grafting and percutaneous coronary intervention. Regado's innovative approach involves the use of antithrombotic aptamers combined with controlling agents, which target both arterial and venous thrombosis, aiming to enhance patient safety and treatment efficacy.

Cardioxyl Pharmaceuticals

Series B in 2012
Cardioxyl Pharmaceuticals is a privately held, clinical stage biopharmaceutical company focused on developing therapies for cardiovascular disease. The company specializes in nitroxyl technology, which is aimed at addressing areas of cardiovascular treatment where existing therapies are lacking or ineffective. Cardioxyl has developed a robust portfolio of pre-clinical and clinical candidates, with its lead compound, CXL-1020, currently in clinical development for Acute Decompensated Heart Failure, a prevalent condition among patients over 65 years of age that often leads to hospitalization. Through its innovative approach, Cardioxyl aims to enhance treatment options for patients suffering from cardiovascular diseases.

Argos Therapeutics

Series D in 2012
Argos Therapeutics, Inc. was a biotechnology company based in Durham, North Carolina, focused on developing personalized immunotherapies for cancer, infectious diseases, and autoimmune disorders. It utilized its proprietary Arcelis technology platform to create individualized treatments, including rocapuldencel-T, which was undergoing Phase III clinical trials for metastatic renal cell carcinoma, and AGS-004, in Phase II trials for human immunodeficiency virus. The company's product pipeline also included therapies aimed at transplant rejection and autoimmune conditions. Founded in 1997 and originally named Merix Bioscience, Argos Therapeutics aimed to address significant unmet medical needs in the field of immuno-oncology. However, on September 24, 2019, the company filed for Chapter 7 bankruptcy, leading to its cessation of operations.

Metabolon

Series D in 2011
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

Digitalsmiths

Series C in 2011
Digitalsmiths is a technology company based in Durham, North Carolina, specializing in video indexing and digital content publishing. Founded in 2006, it provides video providers with the tools to access video archives and deliver personalized viewing experiences through precise and actionable video metadata. Its solutions are versatile, supporting various content formats and devices, which enhances user engagement and monetization opportunities across mobile, broadband, tablet, and television platforms. Digitalsmiths serves prominent clients in the entertainment industry, including major Hollywood studios, broadcasters, and publishers. The company's innovative algorithms facilitate effective video search and interpretation, allowing content owners and advertisers to maximize the value of their digital video assets.

CardioFocus

Series C in 2011
CardioFocus, Inc. is a biotechnology company based in Marlborough, Massachusetts, that specializes in the development of innovative medical devices for the treatment of cardiac disorders, particularly atrial fibrillation. The company offers a range of products, including the HeartLight Endoscopic Ablation System, which utilizes visually guided laser balloon technology to achieve precise pulmonary vein isolation. This system is complemented by the HeartLight Excalibur Balloon, designed for stable contact and effective lesion creation through direct tissue visualization, and the HeartLight X3 System, which allows for controlled lesion formation. CardioFocus focuses on providing electrophysiologists with advanced tools that enhance the precision and control of ablation treatments, utilizing disposable fiber optic catheters for improved visualization of cardiac anatomy and the treatment of arrhythmias. Founded in 1990, CardioFocus continues to pursue advancements in ablation technologies to better meet the needs of patients and healthcare providers.

Cardioxyl Pharmaceuticals

Venture Round in 2010
Cardioxyl Pharmaceuticals is a privately held, clinical stage biopharmaceutical company focused on developing therapies for cardiovascular disease. The company specializes in nitroxyl technology, which is aimed at addressing areas of cardiovascular treatment where existing therapies are lacking or ineffective. Cardioxyl has developed a robust portfolio of pre-clinical and clinical candidates, with its lead compound, CXL-1020, currently in clinical development for Acute Decompensated Heart Failure, a prevalent condition among patients over 65 years of age that often leads to hospitalization. Through its innovative approach, Cardioxyl aims to enhance treatment options for patients suffering from cardiovascular diseases.

StrikeIron

Venture Round in 2010
StrikeIron specializes in Data-as-a-Service (DaaS), providing a comprehensive suite of data quality solutions through its cloud platform, IronCloud. The company offers services such as address verification, email verification, phone validation, phone append, SMS text messaging, and sales tax solutions, catering to a diverse range of industries. Its web services can be seamlessly integrated into various applications and systems, enhancing data accuracy and communication efficiency. Additionally, StrikeIron's solutions are pre-integrated with prominent platforms, including Salesforce and Magento, allowing for streamlined deployment and use. The company aims to support businesses in improving their data management and communication processes through its innovative cloud-based offerings.

Centice

Series C in 2010
Centice Corporation specializes in developing devices for drug detection and identification. The company offers solutions for identifying prescription drugs, illicit substances, and mixtures, as well as addressing issues related to narcotics enforcement and counterfeiting. Its notable product, the PASS Rx system, enhances the verification process for dispensed medications by capturing the spectral signature of drugs and comparing it to a known database. Founded in 2003 and headquartered in Morrisville, North Carolina, Centice operates through a network of distributors both domestically and internationally, providing vital tools for drug verification and safety. The company was formerly known as Optopo, Inc. and rebranded to Centice Corporation in February 2008.

Regado Biosciences

Series D in 2009
Regado Biosciences is a biopharmaceutical company focused on the discovery and development of aptamer-based therapeutics, particularly those that offer antidote-controlled solutions for managing anticoagulation. Founded in 2001 and headquartered in Durham, North Carolina, the company has developed REG1, a treatment for patients with acute coronary syndrome undergoing procedures such as coronary artery bypass grafting and percutaneous coronary intervention. Regado's innovative approach involves the use of antithrombotic aptamers combined with controlling agents, which target both arterial and venous thrombosis, aiming to enhance patient safety and treatment efficacy.

Metabolon

Series C in 2009
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

Metabolon

Series C in 2009
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

StrikeIron

Series D in 2009
StrikeIron specializes in Data-as-a-Service (DaaS), providing a comprehensive suite of data quality solutions through its cloud platform, IronCloud. The company offers services such as address verification, email verification, phone validation, phone append, SMS text messaging, and sales tax solutions, catering to a diverse range of industries. Its web services can be seamlessly integrated into various applications and systems, enhancing data accuracy and communication efficiency. Additionally, StrikeIron's solutions are pre-integrated with prominent platforms, including Salesforce and Magento, allowing for streamlined deployment and use. The company aims to support businesses in improving their data management and communication processes through its innovative cloud-based offerings.

Digitalsmiths

Series B in 2008
Digitalsmiths is a technology company based in Durham, North Carolina, specializing in video indexing and digital content publishing. Founded in 2006, it provides video providers with the tools to access video archives and deliver personalized viewing experiences through precise and actionable video metadata. Its solutions are versatile, supporting various content formats and devices, which enhances user engagement and monetization opportunities across mobile, broadband, tablet, and television platforms. Digitalsmiths serves prominent clients in the entertainment industry, including major Hollywood studios, broadcasters, and publishers. The company's innovative algorithms facilitate effective video search and interpretation, allowing content owners and advertisers to maximize the value of their digital video assets.

Unitrends

Series C in 2008
Unitrends, Inc. is a developer and provider of comprehensive enterprise backup and continuity solutions based in Burlington, Massachusetts. Founded in 1989, the company offers a range of products designed to protect and recover data across physical, virtual, and cloud environments. Its flagship Recovery Series backup appliance integrates enterprise backup, ransomware detection, and cloud continuity into a single platform. Additional offerings include specialized backup software for VMware, automation tools for cloud migration, and solutions for long-term data retention and compliance management. Unitrends also provides Recovery-as-a-Service, advanced security features utilizing machine learning, and analytics to enhance disaster recovery planning. The company markets its products through a network of partners both in the United States and internationally, enabling clients to focus on their core business while ensuring robust data protection. Unitrends operates as a subsidiary of Kaseya Limited.

Aldagen

Series D in 2008
Aldagen is a biopharmaceutical company focused on developing proprietary regenerative cell therapies to address significant unmet medical needs. The company has four product candidates currently in clinical trials. The most advanced candidate, ALD-101, is undergoing a pivotal Phase 3 clinical trial to assess its efficacy in enhancing umbilical cord blood transplants for pediatric patients with inherited metabolic diseases. In addition, Aldagen is conducting or supporting Phase 1 or Phase 1/2 clinical trials for three other candidates: ALD-151, aimed at improving cord blood transplants for leukemia treatment; ALD-301, designed to address critical limb ischemia; and ALD-201, which targets ischemic heart failure.

Centice

Series B in 2007
Centice Corporation specializes in developing devices for drug detection and identification. The company offers solutions for identifying prescription drugs, illicit substances, and mixtures, as well as addressing issues related to narcotics enforcement and counterfeiting. Its notable product, the PASS Rx system, enhances the verification process for dispensed medications by capturing the spectral signature of drugs and comparing it to a known database. Founded in 2003 and headquartered in Morrisville, North Carolina, Centice operates through a network of distributors both domestically and internationally, providing vital tools for drug verification and safety. The company was formerly known as Optopo, Inc. and rebranded to Centice Corporation in February 2008.

Casenet

Series B in 2007
Casenet specializes in customizable care management software solutions aimed at enhancing both individual and population health. The company's platform is designed for payers and care coordinators, enabling effective collaboration between consumers and their healthcare providers in clinical decision-making. Key offerings include case management, disease management, utilization management, and extended enterprise solutions. The software facilitates efficient care delivery coordination and features unique workflow management that integrates various data sources. This comprehensive approach allows clinicians to gain a holistic view of each member, making it easier to identify coordination opportunities, ultimately improving productivity and care outcomes.

Altiris Therapeutics

Series B in 2007
Altiris Therapeutics develops and commercializes drugs to treat metastatic cancer. The company offers CXCR4 receptor, which acts as a mediator of cellular and chemical trafficking; and Emtriva, which is used for the treatment of HIV Infection. Altiris Therapeutics was founded in 2005 and is based in Atlanta, Georgia.

Digitalsmiths

Series A in 2007
Digitalsmiths is a technology company based in Durham, North Carolina, specializing in video indexing and digital content publishing. Founded in 2006, it provides video providers with the tools to access video archives and deliver personalized viewing experiences through precise and actionable video metadata. Its solutions are versatile, supporting various content formats and devices, which enhances user engagement and monetization opportunities across mobile, broadband, tablet, and television platforms. Digitalsmiths serves prominent clients in the entertainment industry, including major Hollywood studios, broadcasters, and publishers. The company's innovative algorithms facilitate effective video search and interpretation, allowing content owners and advertisers to maximize the value of their digital video assets.

Regado Biosciences

Series C in 2007
Regado Biosciences is a biopharmaceutical company focused on the discovery and development of aptamer-based therapeutics, particularly those that offer antidote-controlled solutions for managing anticoagulation. Founded in 2001 and headquartered in Durham, North Carolina, the company has developed REG1, a treatment for patients with acute coronary syndrome undergoing procedures such as coronary artery bypass grafting and percutaneous coronary intervention. Regado's innovative approach involves the use of antithrombotic aptamers combined with controlling agents, which target both arterial and venous thrombosis, aiming to enhance patient safety and treatment efficacy.

Agility Healthcare Solutions

Series A in 2007
Agility Healthcare Solutions specializes in providing RFID-enabled workflow management solutions tailored for the healthcare sector. The company develops real-time location system technologies that enable hospitals to track the physical location of patients, assets, and staff. Its product offerings include AgileTrac Access, which helps healthcare organizations manage mobile assets, and AgileTrac Asset Manager, designed to monitor the usage and status of various assets. Additionally, AgileTrac Patient Flow gathers data on the movement of patients and assets within facilities, facilitating better care direction. Other solutions include AgileTrac Bed Manager for automating bed management processes, AgileTrac ED for emergency department control, and AgileTrac Surgical Services for managing surgical patient flow and resources. Founded in 2002, Agility Healthcare Solutions is based in Glen Allen, Virginia.

Recordant

Series B in 2007
Recordant, Inc. develops and markets audio-capture technology that empowers organizations to improve sales and customer service by recording, analyzing, and transforming face-to-face conversations between associates and the public into actionable intelligence. It offers archival, analytics, consulting, training, assessments, capture, playback, and forensics solutions in the areas of market research, sales force optimization, compliance, training retention and reinforcement, and risk management. The company also provides personal recording devices, aggregators, desktop aggregators, handset interface devices, microphone interface devices, and USB interface devices, as well as SoundMirror, a Web-based application that ensures access to business recordings and data. Recordant, Inc. serves automotive, retail, government, hospitality, law enforcement, financial services, and higher education markets. The company was founded in 2005 and is headquartered in Alpharetta, Georgia. On February 10, 2009, Recordant, Inc. filed a voluntary petition for liquidation under Chapter 7 in the U.S. Bankruptcy Court for the Northern District of Georgia, Atlanta.

Aldagen

Series C in 2006
Aldagen is a biopharmaceutical company focused on developing proprietary regenerative cell therapies to address significant unmet medical needs. The company has four product candidates currently in clinical trials. The most advanced candidate, ALD-101, is undergoing a pivotal Phase 3 clinical trial to assess its efficacy in enhancing umbilical cord blood transplants for pediatric patients with inherited metabolic diseases. In addition, Aldagen is conducting or supporting Phase 1 or Phase 1/2 clinical trials for three other candidates: ALD-151, aimed at improving cord blood transplants for leukemia treatment; ALD-301, designed to address critical limb ischemia; and ALD-201, which targets ischemic heart failure.

Cardioxyl Pharmaceuticals

Series A in 2006
Cardioxyl Pharmaceuticals is a privately held, clinical stage biopharmaceutical company focused on developing therapies for cardiovascular disease. The company specializes in nitroxyl technology, which is aimed at addressing areas of cardiovascular treatment where existing therapies are lacking or ineffective. Cardioxyl has developed a robust portfolio of pre-clinical and clinical candidates, with its lead compound, CXL-1020, currently in clinical development for Acute Decompensated Heart Failure, a prevalent condition among patients over 65 years of age that often leads to hospitalization. Through its innovative approach, Cardioxyl aims to enhance treatment options for patients suffering from cardiovascular diseases.

Cantex Pharmaceuticals

Series B in 2006
Cantex Pharmaceuticals is a biotechnology company focused on developing innovative cancer treatments by modifying existing therapies. The company has two primary development programs that utilize known chemical entities to address significant unmet medical needs in oncology. One of its key products is ODSH, a low anticoagulant heparin derivative aimed at mitigating the adverse effects of chemotherapy on platelet counts. Additionally, Cantex offers Disulfiram-Copper Chelate, which employs multiple mechanisms to target cancer stem cells, making it a potential treatment option for metastatic breast cancer, pancreatic cancer, and glioblastoma. Established in 2002 and based in Weston, Florida, Cantex Pharmaceuticals is dedicated to creating safer and more effective therapeutic options for patients facing life-threatening disorders.

Visitar

Series A in 2006
Visitar is a world wide network of travel websites that aim to inform.

Metabolon

Series B in 2006
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

StrikeIron

Series B in 2005
StrikeIron specializes in Data-as-a-Service (DaaS), providing a comprehensive suite of data quality solutions through its cloud platform, IronCloud. The company offers services such as address verification, email verification, phone validation, phone append, SMS text messaging, and sales tax solutions, catering to a diverse range of industries. Its web services can be seamlessly integrated into various applications and systems, enhancing data accuracy and communication efficiency. Additionally, StrikeIron's solutions are pre-integrated with prominent platforms, including Salesforce and Magento, allowing for streamlined deployment and use. The company aims to support businesses in improving their data management and communication processes through its innovative cloud-based offerings.

Cropsolution

Series C in 2005
Cropsolution uses chemistry technology to discover and develop agrochemicals to protect crops from diseases, weeds, and pests.

Synchris

Venture Round in 2005
Synchris (formerly MAP ROI Systems) is a developer of G-Force(TM), the most effective integrated, collaborative, end-to-end web based system for identifying, qualifying, proposing and managing government contracts.

ALN Medical Management

Series A in 2005
ALN Medical Management, LLC offers revenue cycle management and electronic medical record (EMR) services primarily to physician practices across the United States. Founded in 2000 and headquartered in Littleton, Colorado, the company provides a range of services, including cloud-based PM/EMR hosting, compliance support, billing and coding assistance, and data security. Its EMR services encompass business intelligence, standard and custom reporting, and support for various reimbursement models, particularly those beyond fee-for-service arrangements. ALN Medical Management caters to a diverse clientele in multiple clinical specialties, including pain management, pediatrics, and orthopedics. With over 130 employees and operational centers in Nebraska, Oklahoma, and California, the company is dedicated to helping physicians maintain independence and effectively manage their practices.

Nextreme Thermal Solutions

Series A in 2005
Nextreme designs and manufactures micro-scale thermal and power management products for the semiconductor, photonics, consumer, automotive and defense/aerospace industries. The company has embedded cooling and power generation capabilities into the widely accepted copper pillar bumping process used in high-volume electronic packaging. Nextreme’s breakthrough addresses the most challenging thermal and power management constraints in electronics today, and delivers the only fully-scalable technology solution by leveraging the existing, high-volume flip chip manufacturing infrastructure. By minimizing the need for manufacturing changes and focusing on developing a seamless design-in solution, Nextreme is changing the future of thermal and power management for the entire electronics industry.

StrikeIron

Series A in 2005
StrikeIron specializes in Data-as-a-Service (DaaS), providing a comprehensive suite of data quality solutions through its cloud platform, IronCloud. The company offers services such as address verification, email verification, phone validation, phone append, SMS text messaging, and sales tax solutions, catering to a diverse range of industries. Its web services can be seamlessly integrated into various applications and systems, enhancing data accuracy and communication efficiency. Additionally, StrikeIron's solutions are pre-integrated with prominent platforms, including Salesforce and Magento, allowing for streamlined deployment and use. The company aims to support businesses in improving their data management and communication processes through its innovative cloud-based offerings.

Neotropix

Series A in 2005
Neotropix, Inc. is a biotechnology company based in Malvern, Pennsylvania, focused on the development and commercialization of oncolytic viruses for the treatment of neuroendocrine cancers. Founded in 2003, the company is advancing its lead product, NTX010, a naturally-occurring virus designed to selectively attack and destroy cancer cells associated with various neuroendocrine tumors, including small cell lung cancer, carcinoid, and neuroblastoma. By harnessing the therapeutic potential of these viruses, Neotropix aims to provide effective treatment options for patients with challenging cancer types.

HyperBranch Medical Technology

Series A in 2005
HyperBranch Medical Technology, Inc. is a medical device company focused on developing and marketing innovative products for traumatic and surgically induced wounds. Its flagship product, OcuSeal, is a liquid ocular bandage that provides an immediate protective barrier for the eye by covering openings on its surface. The company also produces Adherus Dural Sealant, which assists in dural repair during cranial and spinal surgeries, including treatments for intracranial aneurysms and tumors. Additionally, HyperBranch offers Adherus Hernia Mesh Fixation, a device designed to replace traditional methods such as tacks and sutures in hernia repair procedures. The company's biosurgical devices aim to enhance patient recovery by reducing complications during surgery.

Unitrends

Series B in 2005
Unitrends, Inc. is a developer and provider of comprehensive enterprise backup and continuity solutions based in Burlington, Massachusetts. Founded in 1989, the company offers a range of products designed to protect and recover data across physical, virtual, and cloud environments. Its flagship Recovery Series backup appliance integrates enterprise backup, ransomware detection, and cloud continuity into a single platform. Additional offerings include specialized backup software for VMware, automation tools for cloud migration, and solutions for long-term data retention and compliance management. Unitrends also provides Recovery-as-a-Service, advanced security features utilizing machine learning, and analytics to enhance disaster recovery planning. The company markets its products through a network of partners both in the United States and internationally, enabling clients to focus on their core business while ensuring robust data protection. Unitrends operates as a subsidiary of Kaseya Limited.

Metabolon

Series A in 2004
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

StrikeIron

Series A in 2004
StrikeIron specializes in Data-as-a-Service (DaaS), providing a comprehensive suite of data quality solutions through its cloud platform, IronCloud. The company offers services such as address verification, email verification, phone validation, phone append, SMS text messaging, and sales tax solutions, catering to a diverse range of industries. Its web services can be seamlessly integrated into various applications and systems, enhancing data accuracy and communication efficiency. Additionally, StrikeIron's solutions are pre-integrated with prominent platforms, including Salesforce and Magento, allowing for streamlined deployment and use. The company aims to support businesses in improving their data management and communication processes through its innovative cloud-based offerings.

WiDeFi

Series A in 2004
WideFi Networks, LLC is a technology company with a vision to create a safer internet. Their mission is to create the safest and simplest products that help you protect your family online. WideFi's "Best in Class" cloud-based software SaferNet offers complete online protection and a full-featured online protection system for your family that includes: All devices, Anywhere Protection (Wi-Fi or cellular networks worldwide), Unlimited Schedules and off times, 84 Content filters, GPS Tracking, White or Blacklist Apps & URLs with an on/off toggle, as well as the ability to Monitor everything coming across your network and devices. We also send real-time alerts when someone wanders to risky sites and Unlimited Admins for accountability. All this and more for as little as $7.99 a month.

PsiloQuest

Series B in 2004
PsiloQuest develops and commercializes CMP polishing pads for the semiconductor industry.

Metabolon

Series A in 2003
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

XActional

Venture Round in 2003
XActional

StemCo Biomedical

Series B in 2003
StemCo Biomedical, Inc. was founded in 1999 and is located in the Research Triangle Park area of NC. The Company is engaged in the development, manufacture and distribution of a series of medical products designed to improve therapeutic transplantation of adult hematopoetic stem and progenitor cells derived from bone marrow, peripheral blood or umbilical cord blood. Addressing a market of more than $1 billion annually, the Company will have a series of products on the market starting in 2002 that identify, sort and custom-engineer stem cell grafts based upon cellular expression of ALDH resulting in what may be better, more effective stem cell transplants in the future.

Regado Biosciences

Series A in 2003
Regado Biosciences is a biopharmaceutical company focused on the discovery and development of aptamer-based therapeutics, particularly those that offer antidote-controlled solutions for managing anticoagulation. Founded in 2001 and headquartered in Durham, North Carolina, the company has developed REG1, a treatment for patients with acute coronary syndrome undergoing procedures such as coronary artery bypass grafting and percutaneous coronary intervention. Regado's innovative approach involves the use of antithrombotic aptamers combined with controlling agents, which target both arterial and venous thrombosis, aiming to enhance patient safety and treatment efficacy.

VetCentric

Venture Round in 2002
VetCentric, Inc., based near Baltimore, MD, is a national veterinary-focused pharmacy that specializes in home delivery of FDA- and EPA-approved pharmaceuticals, compounded medications, and therapeutic diets for pets. The company provides a comprehensive range of services that includes customized online stores, home delivery, and client communication tools for veterinary practices. VetCentric is accredited by Vet-VIPPS and emphasizes the importance of the Veterinarian-Client-Patient relationship in its operations, allowing veterinarians to maintain a central role in patient care. By enhancing service quality, promoting compliance, and reducing operational costs for veterinary practices, VetCentric aims to improve the overall experience for both veterinarians and pet owners.

TriVirix International

Series D in 2002
TriVirix International is a U.S.-based manufacturer and designer of electro-mechanical medical devices, diagnostic tools, and life-science equipment. Headquartered in Milaca, Minnesota, the company specializes in producing a range of products, including ribo printers, point-of-care blood testing analyzers, volumetric infusion pumps, and vital sign monitors. TriVirix International focuses on delivering innovative solutions for the healthcare industry, addressing the needs of medical professionals and enhancing patient care through advanced technology.

PhyFlex Networks

Series B in 2002
PhyFlex Networks is a business services software and broadband access company that creates new business models for cable operators through its True Broadband solution. True Broadband includes a comprehensive software suite for the creation, provisioning, and management of end-to-end broadband services dynamically and on demand.

Cropsolution

Series A in 2002
Cropsolution uses chemistry technology to discover and develop agrochemicals to protect crops from diseases, weeds, and pests.

Norak Biosciences

Series B in 2002
Norak Biosciences, Inc., headquartered in Research Triangle Park, NC, is a private biotechnology company. Norak is utilizing its proprietary Transfluor technology to become a world leader in the discovery and development of drugs that regulate G protein-coupled receptors.

Regado Biosciences

Seed Round in 2002
Regado Biosciences is a biopharmaceutical company focused on the discovery and development of aptamer-based therapeutics, particularly those that offer antidote-controlled solutions for managing anticoagulation. Founded in 2001 and headquartered in Durham, North Carolina, the company has developed REG1, a treatment for patients with acute coronary syndrome undergoing procedures such as coronary artery bypass grafting and percutaneous coronary intervention. Regado's innovative approach involves the use of antithrombotic aptamers combined with controlling agents, which target both arterial and venous thrombosis, aiming to enhance patient safety and treatment efficacy.

Zambeel,Inc.

Series B in 2001
Zambeel, Inc. is building an enterprise-class storage system to address today’s high-growth data environments, where up to hundreds of terabytes of data need to be stored reliably, managed efficiently, and accessed through high-speed networks.

TriVirix International

Series C in 2001
TriVirix International is a U.S.-based manufacturer and designer of electro-mechanical medical devices, diagnostic tools, and life-science equipment. Headquartered in Milaca, Minnesota, the company specializes in producing a range of products, including ribo printers, point-of-care blood testing analyzers, volumetric infusion pumps, and vital sign monitors. TriVirix International focuses on delivering innovative solutions for the healthcare industry, addressing the needs of medical professionals and enhancing patient care through advanced technology.

StemCo Biomedical

Series A in 2000
StemCo Biomedical, Inc. was founded in 1999 and is located in the Research Triangle Park area of NC. The Company is engaged in the development, manufacture and distribution of a series of medical products designed to improve therapeutic transplantation of adult hematopoetic stem and progenitor cells derived from bone marrow, peripheral blood or umbilical cord blood. Addressing a market of more than $1 billion annually, the Company will have a series of products on the market starting in 2002 that identify, sort and custom-engineer stem cell grafts based upon cellular expression of ALDH resulting in what may be better, more effective stem cell transplants in the future.

Porivo Technologies

Venture Round in 2000
Porivo Technologies, Inc. is developing an Internet-enabled distributed computing platform to harness the unused processing power of idle PCs. By aggregating this tremendous underutilized resource, and creating a sizeable network of users, Porivo's software will create a massively parallel meta-computer with incredible processing power.

Alerts.com

Series B in 2000
Alerts.com remotely monitors Web sites to deliver personalized, persistent search results via wireless devices, interactive voice, text and email. The Alerts.com system offers both content alerting capabilities and delivery of content directly to wireless devices using SMS or WAP protocols. Offered as a service through our partners and through Alerts.com's own Internet site, users request to be notified when specific Web content - like a news story or a product price - satisfies the user's alert parameters. The Alerts.com system provides business-to-business and business-to-consumer markets with a seamless, diligent infrastructure service that helps build and manage customer relationships by delivering information when and where people need it. The service, by exposing and delivering dynamic content notifications, generates qualified repeat visits to partners' sites and serves an indispensable role in opt-in, affinity-based marketing efforts.

Engenia Software

Series C in 2000
Engenia Software, developer of an XML-based, Web-enabled, out-of-the-box "Intelligent Dashboard" for the computer desktop.

Interadnet

Venture Round in 2000
Interadnet Inc. is a company that specializes in automated ad tracking technology and digital advertising services. It provides an internet advertising platform designed to enhance the effectiveness of online advertising campaigns. By optimizing and tracking advertising investments, Interadnet enables clients to efficiently manage their digital marketing efforts, ensuring better performance and return on investment.

Emageon

Series B in 2000
Emageon specializes in enterprise-level information technology solutions for the management and analysis of digital medical images within healthcare organizations. The company develops software that enables physicians and healthcare professionals to efficiently manage, access, and visualize a wide range of medical content. Its offerings include advanced visualization tools, clinical content management systems, and streamlined clinical workflows, all designed to enhance the delivery of healthcare services. Emageon's focus is on optimizing the handling of multi-specialty medical information, thereby improving patient care and operational efficiency for healthcare providers.

Opsware

Series B in 2000
Opsware, Inc. is a software company located in Sunnyvale, California, specializing in data center automation products aimed at enterprise customers, government agencies, and service providers across various industries. Originally founded as Loudcloud in 1999, the company transitioned to Opsware after divesting its managed services division in 2002. Opsware's offerings focus on server and network device provisioning, configuration, and management, leveraging automated server life-cycle management technology developed in-house. The company expanded its capabilities through strategic acquisitions, including Tangram Enterprise Solutions in 2003 for asset management, Rendition Networks in 2004 for network device configuration, CreekPath in 2006 for storage provisioning, and iConclude in 2007 for run-book automation. In July 2007, HP announced its intention to acquire Opsware for $1.6 billion, marking one of its largest acquisitions.

Blackboard

Venture Round in 2000
Blackboard Inc. is a leading provider of enterprise technology and innovative solutions for the education sector, catering to higher education, K-12, business, and government markets. Founded in 1997 and headquartered in Reston, Virginia, the company offers a diverse range of products designed to enhance the teaching and learning experience. Its flagship platform, Blackboard Learn, supports academic goals through a comprehensive learning management system, while Blackboard Collaborate facilitates interactive and mobile learning. Additional offerings include Blackboard Analytics, which converts data into actionable insights, and Blackboard SafeAssign, which helps identify plagiarism in student submissions. The company also provides tools for accessibility, student support, and community engagement, such as Blackboard Ally and Blackboard Connect. With a global presence, Blackboard aims to improve educational outcomes and institutional performance by leveraging technology to streamline processes and enhance communication among educational stakeholders.

TriVirix International

Series B in 2000
TriVirix International is a U.S.-based manufacturer and designer of electro-mechanical medical devices, diagnostic tools, and life-science equipment. Headquartered in Milaca, Minnesota, the company specializes in producing a range of products, including ribo printers, point-of-care blood testing analyzers, volumetric infusion pumps, and vital sign monitors. TriVirix International focuses on delivering innovative solutions for the healthcare industry, addressing the needs of medical professionals and enhancing patient care through advanced technology.

Technauts

Series B in 1999
Technauts to meet the demand of small to medium businesses, departments and branch offices for simple affordable.

TriVirix International

Series A in 1999
TriVirix International is a U.S.-based manufacturer and designer of electro-mechanical medical devices, diagnostic tools, and life-science equipment. Headquartered in Milaca, Minnesota, the company specializes in producing a range of products, including ribo printers, point-of-care blood testing analyzers, volumetric infusion pumps, and vital sign monitors. TriVirix International focuses on delivering innovative solutions for the healthcare industry, addressing the needs of medical professionals and enhancing patient care through advanced technology.

Engenia Software

Series B in 1999
Engenia Software, developer of an XML-based, Web-enabled, out-of-the-box "Intelligent Dashboard" for the computer desktop.

Alerts.com

Series A in 1999
Alerts.com remotely monitors Web sites to deliver personalized, persistent search results via wireless devices, interactive voice, text and email. The Alerts.com system offers both content alerting capabilities and delivery of content directly to wireless devices using SMS or WAP protocols. Offered as a service through our partners and through Alerts.com's own Internet site, users request to be notified when specific Web content - like a news story or a product price - satisfies the user's alert parameters. The Alerts.com system provides business-to-business and business-to-consumer markets with a seamless, diligent infrastructure service that helps build and manage customer relationships by delivering information when and where people need it. The service, by exposing and delivering dynamic content notifications, generates qualified repeat visits to partners' sites and serves an indispensable role in opt-in, affinity-based marketing efforts.

Accipiter

Series A in 1997
Accipiter offers online advertising solutions and services worldwide. It offers AdManager, an ad management solution that allows to increase targeting capabilities to speed ad delivery and to monitor and control inventory projections in real-time; Ad Trafficking, which provides AdManager hosted clients with outsourced and customized solution to administer the campaign management process; AdMarket, a real-time bid-for-placement technology enabling publishers to operate branded online advertising marketplaces and transact with advertisers who are requesting a pay-per-click pricing model; and Visitor Interest Behavioral Engine, a behavioral targeting solution that delivers promotions and content to interested prospects. Accipiter is based in Raleigh, North Carolina with an additional office in London, United Kingdom.

Accipiter

Seed Round in 1996
Accipiter offers online advertising solutions and services worldwide. It offers AdManager, an ad management solution that allows to increase targeting capabilities to speed ad delivery and to monitor and control inventory projections in real-time; Ad Trafficking, which provides AdManager hosted clients with outsourced and customized solution to administer the campaign management process; AdMarket, a real-time bid-for-placement technology enabling publishers to operate branded online advertising marketplaces and transact with advertisers who are requesting a pay-per-click pricing model; and Visitor Interest Behavioral Engine, a behavioral targeting solution that delivers promotions and content to interested prospects. Accipiter is based in Raleigh, North Carolina with an additional office in London, United Kingdom.
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