CLI Ventures

CLI Ventures is a global venture capital and private equity investment firm based in Mountain View, California, with additional offices in Palo Alto, New York, Boston, San Diego, Beijing, and Shenzhen. Founded in 2010, the firm manages approximately $1 billion and has invested in over 200 portfolio companies. CLI Ventures focuses on sectors including healthcare, real estate, software, and services, aiming to support innovative companies in these fields.

Zhi Li

Managing Partner and Founding Partner

Zhongmin Pi

Managing Partner

Jeffrey Su Ph.D

Partner and Chief Strategy Officer

23 past transactions

Sentieon

Series B in 2021
Sentieon, Inc. is a bioinformatics company based in Mountain View, California, founded in 2014. It specializes in developing and commercializing cloud-based solutions for the life sciences and clinical markets. Sentieon offers a range of bioinformatics tools designed for processing genomics data with a focus on accuracy, efficiency, and quick turnaround times. Its notable products include Sentieon DNAseq, which aids in germline DNA analysis, and Sentieon TNseq, designed for detecting tumor-normal somatic variants. These software-only tools boast scalability and upgradeability, leveraging optimized algorithms to improve computing performance. Sentieon aims to enhance the capabilities of scientists and clinicians by providing precision tools that facilitate comprehensive tumor characterization and other critical bioinformatics processes.

Synlogic

Series C in 2017
Synlogic, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, specializing in the development of synthetic biotic medicines aimed at treating metabolic, inflammatory, and cancer-related diseases. The company’s lead therapeutic program, SYNB1618, is currently undergoing Phase I/IIa clinical trials for the treatment of phenylketonuria, a rare genetic metabolic disorder. Additionally, Synlogic is advancing SYNB1891, an intratumoral synthetic biotic medicine in Phase I clinical trials targeting solid tumors and lymphoma. The company employs a proprietary approach that utilizes engineered probiotics, specifically Escherichia coli Nissle 1917, to create GI-restricted oral therapies that are non-colonizing and reversible, facilitating easier administration and storage. Synlogic is also exploring treatments for other conditions, including secondary hyperoxaluria, inflammatory bowel disease, and various metabolic disorders, and has established a collaboration with Ginkgo Bioworks to further its development efforts.

Immune-Onc Therapeutics

Series A in 2016
Immune-Onc Therapeutics, Inc. is a biopharmaceutical company based in Palo Alto, California, founded in 2016. The company specializes in the discovery and development of innovative biologic treatments, particularly aiming to create therapeutic antibodies for cancer. Immune-Onc Therapeutics leverages scientific insights related to the tumor microenvironment and immune suppressive pathways to develop first-in-class biotherapeutics. By targeting myeloid cells, it aims to disarm immune suppression within tumors, facilitating new immunomodulatory approaches for cancer treatment. The company's focus on advancing novel immuno-oncology products positions it to provide effective new treatment options for cancer patients.

Eonite Perception

Seed Round in 2016
Eonite Perception Inc. is a technology company based in Palo Alto, California, specializing in the development of advanced inside-out positional tracking software. Founded in 2015, Eonite creates three-dimensional mapping and ego-tracking systems that utilize commodity dense depth sensors. Their products cater to various markets, including augmented and virtual reality, home-scale 3D scanning, and robotics. The company offers a proprietary software development kit that enables developers to create applications across multiple industries, such as entertainment, architecture, engineering, and geographical information systems. Eonite’s AI-based software employs advanced computer vision algorithms to achieve sub-millimeter accuracy, facilitating improved localization and obstacle detection for robots and drones while maintaining low power consumption.

Medigo

Series A in 2016
Medigo, headquartered in Berlin, operates a digital platform that facilitates medical travel. It connects users with clinics worldwide, enabling them to search, compare, and coordinate medical procedures. The platform offers features like clinic browsing by procedure or country, filtering by facility type, sorting by price or rating, and clinic comparison based on staff expertise and patient reviews. Medigo also acts as a third-party administrator, supporting organizations in global healthcare navigation, cost containment, and member experience enhancement. It maintains an international provider network and is backed by prominent venture capital firms, employing a diverse team of over 50 individuals.

Aria Pharmaceuticals

Seed Round in 2015
Aria Pharmaceuticals is a preclinical-stage pharmaceutical company focused on discovering and developing novel small molecule therapies for complex and hard-to-treat diseases. Utilizing an artificial intelligence-driven drug discovery platform, Aria aims to redefine traditional drug development processes, significantly reducing the time required for discovery and increasing success rates by up to 30 times. The company builds its own pipeline of therapeutic candidates while also collaborating with biotechnology and pharmaceutical companies to identify and develop new drug candidates. Aria's innovative approach allows it to address a wide array of therapeutic areas and aims to provide breakthrough treatments for over 1,000 diseases. Founded in 2014 and based in Mountain View, California, Aria Pharmaceuticals is committed to advancing healthcare solutions for patients in urgent need.

Civil Maps

Convertible Note in 2015
Civil Maps is a geospatial technology company based in Berkeley, California, specializing in artificial intelligence-driven mapping solutions. The company provides a sensor-agnostic platform for creating high-accuracy, low-cost 3D HD maps that assist heavy-industry clients and governmental agencies, as well as Fortune 100 companies across various sectors including utility, oil and gas, solar, telecommunications, transportation, and forestry. Their innovative technology supports autonomous driving initiatives by allowing vehicles to develop a "mental model" of their surroundings, utilizing proprietary Fingerprint Basemap Technology for effective sensor fusion and centimeter-accurate localization. This capability enhances vehicles' environmental awareness and safety, while also significantly lowering the costs and energy demands associated with the large-scale deployment of autonomous systems like delivery bots.

Skydrop

Seed Round in 2015
Flirtey Technology Pty Ltd specializes in drone delivery services, focusing on urgent medical supplies, retail items, and food delivery across the United States. Founded in 2013 and headquartered in Reno, Nevada, the company aims to enhance lifestyles by providing instant delivery solutions. Flirtey has achieved significant milestones in the drone delivery industry, being the first to conduct an FAA-approved drone delivery, the first to perform a fully autonomous delivery to a home, and the first to launch a commercial drone delivery service.

Genalyte

Series C in 2015
Genalyte, Inc. is a clinical and diagnostic life sciences company based in San Diego, California, that specializes in rapid diagnostic testing solutions for healthcare providers, patients, and researchers. Founded in 2007, Genalyte has developed a unique technology platform employing silicon photonic biosensors to quantify the interactions between biomolecules, such as antibodies and proteins. This innovative approach allows for the direct measurement of protein binding and nucleic acid hybridization, facilitating the monitoring of autoimmune diseases, cancer biomarker screening, and the detection of infectious agents, including Ebola. The company's Maverick platform enables rapid testing in various healthcare settings, with results typically available in under thirty minutes, thereby enhancing patient care and improving resource efficiency within the healthcare system.

iMicrobes

Pre Seed Round in 2015
Industrial Microbes designs and builds microbes that produce better chemicals with lower costs and lower carbon emissions. We use greenhouse gases as the raw materials, including biogas, natural gas, and carbon dioxide. We scale our process with global chemical producers.

CoPromote

Series A in 2015
CoPromote, Inc. operates a social exchange platform designed to assist individuals in expanding their audiences. Founded in 2009 and based in New York, the platform enables users, including artists, bloggers, brands, businesses, and musicians, to promote their content through a community-driven approach. Users can connect with other content creators who recommend promotions to their own networks, find content to share, and engage with new fans. The platform facilitates real-time interactions, allowing users to reach the followers of various influencers and encouraging content exchange through promotions. CoPromote was previously known as Headliner.fm Corp. and rebranded in February 2014.

Propel

Seed Round in 2015
Propel(x), Inc. is an online investment platform that connects investors with early-stage companies in the life sciences, computer sciences, energy, clean technology, and materials sectors. Founded in 2014 and based in Palo Alto, California, Propel(x) focuses on facilitating investments in startups centered around scientific discovery and innovative technologies. The platform enables investors to interact with industry experts, startup executives, and customers, which helps clarify complex technologies and accelerates fundraising efforts for emerging companies. Propel(x) aims to support the growth of pioneering ventures that contribute to significant advancements in various fields.

InsideMaps

Seed Round in 2015
InsideMaps Inc. is a technology company that specializes in creating photorealistic 3D models and floor plans of home interiors, facilitating an enhanced visualization experience for potential home buyers and homeowners. Founded in 2013 and based in Mountain View, California, InsideMaps offers a user-friendly smartphone and tablet application that allows users to generate immersive, web-based 3D environments of their homes. This platform enables users to experiment with virtual interior design, including changing paint colors, flooring, and arranging furniture, as well as customizing retailer offerings. By combining high-definition photography with detailed floor plans, InsideMaps provides clients and real estate owners with comprehensive tools for visualizing properties and planning interior improvements.

Aria Pharmaceuticals

Seed Round in 2015
Aria Pharmaceuticals is a preclinical-stage pharmaceutical company focused on discovering and developing novel small molecule therapies for complex and hard-to-treat diseases. Utilizing an artificial intelligence-driven drug discovery platform, Aria aims to redefine traditional drug development processes, significantly reducing the time required for discovery and increasing success rates by up to 30 times. The company builds its own pipeline of therapeutic candidates while also collaborating with biotechnology and pharmaceutical companies to identify and develop new drug candidates. Aria's innovative approach allows it to address a wide array of therapeutic areas and aims to provide breakthrough treatments for over 1,000 diseases. Founded in 2014 and based in Mountain View, California, Aria Pharmaceuticals is committed to advancing healthcare solutions for patients in urgent need.

HireTeamMate

Seed Round in 2015
HireTeamMate is an employment agency developing a recommended tool throughout the recruiting community.

Voxel

Seed Round in 2015
Voxel is a technology company based in Palo Alto, California, founded in 2013. It specializes in developing a virtualization platform that allows users to build and run mobile applications in the cloud, streaming them directly to client devices. Voxel enhances the mobile app discovery process by creating engaging and interactive mobile advertisements, enabling users to experience applications before making a purchase decision. This approach not only increases user engagement but also contributes to higher lifetime value for users visiting the app store through Voxel's platform.

Publet

Seed Round in 2015
Publet Inc., headquartered in San Francisco, specializes in content marketing software for B2B companies. Its platform transforms traditional white papers and collateral into interactive digital formats, facilitating easy sharing via social media and mobile platforms. When potential leads engage with shared content, Publet tracks interactions and presents a paywall-contact form upon link clicks to capture sales leads.

CStorePro

Series A in 2015
CStorePro Inc. is a software company that offers an online store management and back-office solution tailored for convenience store and gas station owners in the United States. Based in Sugar Land, Texas, CStorePro provides a user-friendly SaaS platform that allows operators to monitor sales, inventory, and daily reports from mobile devices. The software enables users to access register reports, manage merchandise and gas prices, and oversee various financial transactions, including payments and inventory management. Founded in 1997, CStorePro aims to simplify retail operations by combining operational and sales data, thereby helping store owners optimize pricing, purchasing, and regulatory compliance. With thousands of users, the company is committed to equipping retailers with modern tools for efficient management of their businesses.

Droplet Robotics

Convertible Note in 2015
Droplet Inc. specializes in developing a robotic water sprinkler system designed to optimize plant irrigation. By utilizing data from weather stations, soil samples, and biological plant information, the system intelligently decides when, where, and how much water to deliver. This innovative solution caters to a variety of plant types, including grass, trees, and potted plants, and is applicable for use in gardens and lawns by homeowners. Founded in 2013 and based in the United States, Droplet Inc. aims to enhance irrigation efficiency while conserving water, leveraging advancements in robotics and cloud computing to transform traditional sprinkler systems.

Arthena

Seed Round in 2014
Arthena is a financial technology company that specializes in creating quantitative investment strategies for the art market. By leveraging data science, Arthena has developed a platform that allows investors to access art as an asset class. The company focuses on enhancing transparency in art investing, providing insights into acquired assets and artists. Through its platform, investors can pool their capital to form syndicates, enabling them to invest in diversified collections of fine art tailored to their risk tolerance. This innovative approach opens up opportunities for individuals to participate in the art world, traditionally reserved for a select few.

popSLATE

Convertible Note in 2014
popSLATE Media, Inc. specializes in innovative smartphone accessories by offering a smart digital case that enhances the user experience. Based in San Francisco, the company has developed an integrated digital smartphone cover featuring an always-on ePaper screen located on the back of the phone. This unique device allows users to display images from a variety of sources, including their photo gallery, camera, social media, and dedicated popSLATE artist channels. By combining the functionalities of a smartwatch, battery case, and e-reader, popSLATE enhances how individuals interact with their smartphones, providing an additional screen for easy access to personalized content and media.

Weft

Seed Round in 2014
Weft, Inc. is a global logistics data company based in Cambridge, Massachusetts, established in 2013. It leverages a combination of sensors and supply chain analytics to enhance real-time asset intelligence, helping businesses minimize disruptions and boost operational productivity. The Weft platform offers insights and visibility through a user-friendly web and mobile interface, enabling clients to track assets in real time using various technologies such as Wi-Fi, BLE, GPS, satellite, and GPRS. It provides analytical capabilities that assess routes, fuel consumption, potential disruptions, and environmental conditions, allowing users to proactively manage logistics challenges. By integrating data from both its own sensors and third-party systems, Weft empowers companies to identify bottlenecks and make informed decisions, ultimately increasing the likelihood of on-time deliveries.

Ntirety

Series B in 2008
Ntirety, Inc. is a provider of comprehensive database management and cloud hosting services, specializing in remote and onsite solutions for businesses. Founded in 2001 and based in Dedham, Massachusetts, the company offers a wide range of services, including remote database administration, database assessment, and on-demand architectural and developer support. Ntirety also focuses on data consulting, providing services such as database consolidation, performance tuning, migration, and compliance audits. With over 20 years of experience, the company emphasizes compliant security embedded throughout its services, supported by three 24/7 US-based security operations centers. This strategic approach helps businesses manage security and compliance effectively, enabling resilient and adaptive operations while ensuring comprehensive data protection.
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