CLI Ventures

CLI Ventures is a global venture capital and private equity investment firm founded in 2010 and based in Mountain View, California. The firm focuses on supporting exceptional entrepreneurs in building innovative healthcare and data analytics companies. With $1 billion under management, CLI Ventures invests across various stages of company development, particularly in the areas of diagnostics, therapeutics, and data applications. The firm operates offices in major cities including Palo Alto, New York, Boston, San Diego, Los Angeles, Beijing, Shanghai, Shenzhen, and Wuhan. CLI Ventures has established a robust team with extensive investment, operational, and scientific expertise, enabling a proactive approach to company development. It has been instrumental in forming over 200 portfolio companies that have contributed to advancements in human health, including products approved in the U.S. and China. The firm has also pioneered successful investment strategies, such as U.S.-China cross-border licensing, and is actively collaborating with health ministries and local governments in China to foster new opportunities.

Zhi Li

Managing Partner and Founding Partner

Zhongmin Pi

Managing Partner

Jeffrey Su Ph.D

Partner and Chief Strategy Officer

24 past transactions

Sentieon

Series B in 2021
Sentieon, Inc. is a biotechnology company founded in 2014 and headquartered in Mountain View, California, specializing in cloud-based bioinformatics solutions for the life sciences and clinical markets. The company develops a suite of bioinformatics tools designed for the efficient processing of genomics data, focusing on high accuracy and computational efficiency. Key products include Sentieon DNAseq, which facilitates germline DNA analysis, and Sentieon TNseq, used for detecting somatic variants in tumor-normal samples. Sentieon's software solutions are characterized by their scalability, deployability, and upgradability, allowing them to adapt to various user needs. The company's advanced algorithms and robust software implementation ensure rapid turnaround times and consistent results, benefiting scientists, clinicians, and patients by enhancing precision in genomic data analysis.

Synlogic

Series C in 2017
Synlogic, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, specializing in the discovery and development of synthetic biotic medicines aimed at treating metabolic, inflammatory, and cancer-related diseases. The company’s lead therapeutic program, SYNB1618, is an oral therapy currently in Phase I/IIa clinical trials for the treatment of phenylketonuria. Additionally, Synlogic is developing SYNB1891, an intratumoral synthetic biotic medicine that is undergoing Phase I clinical trials for the treatment of solid tumors and lymphoma. The company is also exploring synthetic biotics for more common conditions, including inflammatory bowel disease and secondary hyperoxaluria. Synlogic has established a collaboration with Ginkgo Bioworks to advance its development of these innovative therapies.

Immune-Onc Therapeutics

Series A in 2016
Immune-Onc Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Palo Alto, California, founded in 2016. The company specializes in the discovery and development of innovative biologic therapies aimed at treating cancer. Immune-Onc Therapeutics focuses on the tumor microenvironment and immune suppressive pathways, utilizing advanced scientific insights to create novel immuno-oncology products. The company employs a targeted approach to develop first-in-class therapeutic antibodies that disarm immune suppression in tumors, thereby enhancing the immune response against cancer. Through its differentiated pipeline, Immune-Onc Therapeutics aims to provide new treatment options for cancer patients, addressing critical needs in the field of immunology and oncology.

Eonite Perception

Seed Round in 2016
Eonite Perception Inc. specializes in developing inside-out positional tracking software, which facilitates three-dimensional mapping and ego-tracking using commodity dense depth sensors. This technology is applied in various sectors, including augmented and virtual reality, home-scale 3D scanning, and more. The company's offerings include a positional tracking system designed for headsets and a software development kit for creating applications across multiple industries, such as entertainment, robotics, architecture, engineering, construction, and geographical information systems. Founded in 2015 and headquartered in Palo Alto, California, Eonite Perception aims to enhance machine perception, enabling computers to better understand the real world, which is crucial for the future of virtual and augmented reality, as well as robotics and drones.

Medigo

Series A in 2016
Headquartered in Berlin, Medigo enables global access to quality healthcare. Their flagship product was a very popular medical travel platform that simplified the process of arranging treatment abroad. As a third party administrator (TPA), Medigo helps organisations navigate healthcare across the globe with an international provider network, tech-driven cost containment, and an excellent member experience. Medigo is supported by leading VCs such as Accel Partners and Atlantic Labs, and employs a driven team of 50+ people from 25 countries.

Aria Pharmaceuticals

Seed Round in 2015
Aria Pharmaceuticals is a preclinical-stage pharmaceutical company focused on discovering and developing novel small molecule therapies for complex and hard-to-treat diseases. The company leverages an innovative drug discovery approach that significantly accelerates the development process and enhances success rates compared to traditional methods. Aria's technology enables it to build a robust pipeline of therapeutic candidates while also collaborating with biotechnology and pharmaceutical companies to jointly discover and develop new drug candidates. The company aims to address over 1,000 diseases, responding to the urgent need for breakthrough treatments for patients facing challenging health conditions. Incorporated in 2014 and based in Mountain View, California, Aria Pharmaceuticals is committed to advancing healthcare through its advanced drug discovery capabilities.

Civil Maps

Convertible Note in 2015
Civil Maps, a geospatial technology company, provides artificial intelligence based mapping solutions that enables computers to interpret and act on the physical world. The company operates as an on-demand perception and actuation technology company. It serves heavy-industry and governmental customers; Fortune 100 clients; and customers in electrical utilities, oil and gas, solar, telecommunications, transportation, rail, forestry, and more markets. The company is based in Berkeley, California.

Skydrop

Venture Round in 2015
Flirtey Technology Pty Ltd specializes in drone delivery services, focusing on urgent medical supplies, retail items, and food delivery across the United States. Founded in 2013 and headquartered in Reno, Nevada, the company aims to enhance lifestyles by providing instant delivery solutions. Flirtey has achieved significant milestones in the drone delivery industry, being the first to conduct an FAA-approved drone delivery, the first to perform a fully autonomous delivery to a home, and the first to launch a commercial drone delivery service.

Genalyte

Series C in 2015
Genalyte, Inc. is a clinical and diagnostic life science company based in San Diego, California, specializing in rapid diagnostic testing solutions. Founded in 2007, Genalyte has developed an innovative technology platform that utilizes silicon photonic biosensors to quantify biomolecular interactions, such as those between antibodies and proteins. This platform, known as the Maverick, allows for the direct measurement of protein binding and nucleic acid hybridization. Genalyte's technology is employed by healthcare providers, pharmaceutical companies, and academic researchers to monitor autoimmune diseases, screen for cancer biomarkers, detect anti-drug antibodies, and test for infectious agents, including Ebola. The company aims to enhance patient care by enabling rapid diagnostics, with tests typically completed in under thirty minutes, and providing mobile laboratory solutions for real-time diagnostics.

Genalyte

Series C in 2015
Genalyte, Inc. is a clinical and diagnostic life science company based in San Diego, California, specializing in rapid diagnostic testing solutions. Founded in 2007, Genalyte has developed an innovative technology platform that utilizes silicon photonic biosensors to quantify biomolecular interactions, such as those between antibodies and proteins. This platform, known as the Maverick, allows for the direct measurement of protein binding and nucleic acid hybridization. Genalyte's technology is employed by healthcare providers, pharmaceutical companies, and academic researchers to monitor autoimmune diseases, screen for cancer biomarkers, detect anti-drug antibodies, and test for infectious agents, including Ebola. The company aims to enhance patient care by enabling rapid diagnostics, with tests typically completed in under thirty minutes, and providing mobile laboratory solutions for real-time diagnostics.

iMicrobes

Pre Seed Round in 2015
Industrial Microbes designs and builds microbes that produce better chemicals with lower costs and lower carbon emissions. We use greenhouse gases as the raw materials, including biogas, natural gas, and carbon dioxide. We scale our process with global chemical producers.

CoPromote

Series A in 2015
CoPromote, Inc. operates a social exchange platform designed to assist individuals and organizations in expanding their audience. The platform allows users to promote their content within a community, connect with other content creators, and share recommended promotions across various networks. It enables users to discover and share relevant content while facilitating real-time engagement with fans of other influencers. The service caters to a diverse range of content creators, including artists, bloggers, brands, businesses, musicians, and tastemakers. Founded in 2009 and headquartered in New York, CoPromote was previously known as Headliner.fm Corp. before rebranding in February 2014.

InsideMaps

Seed Round in 2015
InsideMaps Inc. specializes in creating 3D models and floor plans of home interiors, allowing potential buyers to visualize properties and enabling homeowners to experiment with furniture arrangements and home improvements in a virtual environment. Established in 2013 and based in Mountain View, California, the company offers a smartphone and tablet application that simplifies the process of generating photorealistic 3D models and virtual tours. This user-friendly app provides innovative tools for visualizing interiors, including options for changing paint and flooring or arranging furniture from retailers. InsideMaps aims to enhance the home buying and renovation experience by providing high-definition photography, detailed floor plans, and immersive 3D environments, making it accessible for anyone to create and explore their ideal living space.

Propel

Seed Round in 2015
Propel(x), Inc. operates an online investment platform that connects investors with early-stage companies in the life sciences, computer sciences, energy/clean-tech, and materials/chemicals sectors. Founded in 2014 and headquartered in Palo Alto, California, the platform facilitates interaction between investors and industry experts, customers, and startup executives, helping to demystify technology and accelerate fundraising efforts for startups. Propel(x) is dedicated to enabling investments in innovative technologies that contribute to scientific advancement and societal progress. The platform empowers individual investors to source, evaluate, and fund pioneering startups, thereby fostering growth and innovation in key sectors.

Aria Pharmaceuticals

Seed Round in 2015
Aria Pharmaceuticals is a preclinical-stage pharmaceutical company focused on discovering and developing novel small molecule therapies for complex and hard-to-treat diseases. The company leverages an innovative drug discovery approach that significantly accelerates the development process and enhances success rates compared to traditional methods. Aria's technology enables it to build a robust pipeline of therapeutic candidates while also collaborating with biotechnology and pharmaceutical companies to jointly discover and develop new drug candidates. The company aims to address over 1,000 diseases, responding to the urgent need for breakthrough treatments for patients facing challenging health conditions. Incorporated in 2014 and based in Mountain View, California, Aria Pharmaceuticals is committed to advancing healthcare through its advanced drug discovery capabilities.

HireTeamMate

Seed Round in 2015
HireTeamMate owns and develops Hiretual, the top recommended recruiting tool by recruiter community leaders. Please get more details by visiting us: https://hiretual.com

Voxel

Seed Round in 2015
Voxel is a company that specializes in a virtualization platform designed to enhance mobile application development. Founded in 2013 and based in Palo Alto, California, Voxel enables users to build applications that run in the cloud, streaming seamlessly to client devices. The company also focuses on transforming mobile advertising by allowing users to engage with apps before making a purchase decision. This "try before they buy" approach enhances the app discovery process, ensuring that each visit to the app store is intentional and contributes to a higher lifetime value for users.

CStorePro

Series A in 2015
CStorePro Inc. is a software company based in Sugar Land, Texas, that specializes in providing online store management and back-office solutions for convenience store and gas station owners in the United States. Founded in 2013, the company offers a user-friendly software-as-a-service (SaaS) platform that enables operators to monitor sales, manage inventory, and generate daily reports directly from their smartphones or tablets. Its solutions facilitate the management of various operational tasks, including pricing adjustments, merchandise sales, and financial transactions, while ensuring compliance with regulatory standards. By integrating operational and sales data, CStorePro helps retailers optimize their pricing, purchasing, and human resources, making it an essential tool for thousands of store owners and operators seeking to streamline their retail operations.

Publet

Seed Round in 2015
Publet, Inc. is a content marketing software company based in San Francisco, California. The firm specializes in amplifying B2B white papers and collateral through social and mobile platforms to generate sales leads. Its software transforms static PDF reports into engaging multimedia content by extracting quotes and text snippets that can be easily shared on social media. When potential leads interact with these posts, Publet tracks their engagement and directs them to a traditional paywall and contact form upon clicking the link. This approach enhances the visibility and accessibility of professional publications while facilitating lead generation for organizations.

Droplet Inc.

Convertible Note in 2015
Droplet Inc. specializes in developing a robotic water sprinkler system designed to optimize plant irrigation. By utilizing data from weather stations, soil samples, and biological plant information, the system intelligently decides when, where, and how much water to deliver. This innovative solution caters to a variety of plant types, including grass, trees, and potted plants, and is applicable for use in gardens and lawns by homeowners. Founded in 2013 and based in the United States, Droplet Inc. aims to enhance irrigation efficiency while conserving water, leveraging advancements in robotics and cloud computing to transform traditional sprinkler systems.

Arthena

Seed Round in 2014
Arthena is a venture-backed financial technology company which has pioneered quantitative strategies for asset acquisition, allowing for targeting investment decisions. Arthena is committed to bringing transparency to art investing, enabling investors to view and learn about acquired assets and artists.

popSLATE

Convertible Note in 2014
popSLATE Media, Inc. is a San Francisco-based company that specializes in a smart digital case designed to enhance the smartphone user experience. This innovative device features an always-on ePaper screen on the back of the phone, allowing users to display images from various sources such as their gallery, camera, friends, artist channels, and social media platforms like Instagram. By integrating the functionalities of a smartwatch, battery case, and e-reader, popSLATE provides a second screen that enables individuals to access and share their favorite content seamlessly.

Weft

Seed Round in 2014
Weft, Inc. is a global logistics data company based in Cambridge, Massachusetts, that specializes in providing real-time asset intelligence to enhance supply chain operations. Established in 2013 and operating as a subsidiary of Genscape, Inc., Weft integrates various tracking technologies, including Wi-Fi, BLE, GPS, satellite, and GPRS, to offer insights into logistics processes. The company's platform allows users to monitor and manage their assets, setting alerts for conditions such as location, temperature, and vibrations. By leveraging predictive analytics, Weft helps shippers anticipate potential bottlenecks by analyzing current locations and planned routes against historical data, enabling proactive adjustments to improve delivery timelines. The platform is accessible through web and mobile applications, and it collaborates with ERP providers, telecommunications companies, and logistics firms to extend its reach and capabilities within the industry.

Ntirety

Series B in 2008
Ntirety is a leader in delivering managed hybrid and multi-cloud solutions to 3200 enterprise customers throughout the globe, serving customers globally from four continents and 14 data centers worldwide. Formed in 2018 through the merger of Hostway and HOSTING, Ntirety is now a powerhouse with over 20 years of experience and unmatched customer service and support. With combined specializations in managing compliant, mission-critical workloads, Ntirety delivers highly secure and always available solutions to thousands of customers around the globe, enabling business to move faster with less risk.
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