CTI Life Sciences Fund L.P.

Glycomine, Inc. is a biotech company focused on developing nanomedicines for rare genetic disorders, particularly those related to protein and lipid glycosylation, which can severely impact patients' health. Established in 2014 and located in San Carlos, California, Glycomine aims to address the significant unmet medical need for effective treatments in the realm of rare diseases, where approximately 95% lack any FDA-approved therapies. The company specializes in creating replacement therapies that utilize a combination of substrates, enzymes, and proteins, delivered through bio-nano materials that target specific cells within clinically relevant organs. By innovating in this area, Glycomine seeks to provide new therapeutic options for patients suffering from disorders of metabolism and protein misfolding.

Epitopea is a biotechnology company focused on developing innovative immunotherapies for cancer treatment by targeting a new class of tumor-specific antigens. The company employs a proprietary approach that combines immunopeptidomics, mass spectrometry, genomics, and bioinformatics to identify conserved, aberrantly expressed tumor-specific antigens hidden within cancer's non-coding DNA. This technology aims to create therapies that effectively eliminate malignant cells while minimizing damage to healthy tissue, thereby reducing side effects and providing lasting benefits for patients. Research conducted by Drs. Claude Perreault and Pierre Thibault at the Institute for Research in Immunology and Cancer at Université de Montréal has been instrumental in the discovery of these novel antigens, known as Cryptigen™ TSAs, which are shared among patients with the same cancer type.

Find Therapeutics Inc. is a biotechnology company focused on developing therapies for inflammatory and fibrotic rare diseases affecting the airways, liver, and gastrointestinal systems. Founded in 2020 and based in Saint-Laurent, Canada, the company specializes in creating peptide-based therapies and GPCR allosteric modulators aimed at treating autoimmune conditions. Utilizing a peptide discovery engine, Find Therapeutics designs peptides that target critical transmembrane domains of receptors involved in essential biological processes. Through its innovative approach, the company aims to advance next-generation treatments for a range of inflammatory diseases.

Ability Pharmaceuticals is a drug discovery and development company based in Barcelona, Spain. It develops human therapeutics targeting cell membranes to treat cancer and other indications with unmet medical needs. Ability Pharmaceuticals is focused on developing new drugs for the treatment of lung cancer and pancreatic cancer. The company develops Lipid Analogue Therapeutics, a new drug class that modifies the composition of the cell membrane and displays a capacity to influence the local organization of lipid structures in the cell membrane, inducing the formation of non-lamellar phase structures. Its development pipeline includes ABTL0812 product in preclinical development; and ABTL1014, a drug candidate in preclinical characterization.

DalCor Pharmaceuticals is focused on developing precision treatments for cardiovascular disease by targeting specific genetic profiles to enhance clinical outcomes. Its primary program, dalcetrapib, aims to reduce cardiovascular events in patients with a distinct genetic marker. A pharmacogenomic analysis from a significant study indicated that patients with acute coronary syndrome possessing an AA polymorphism in the ADCY9 gene experienced fewer cardiovascular events when treated with dalcetrapib, a CETP inhibitor, compared to those receiving a placebo. The company has secured an exclusive worldwide license from Roche for dalcetrapib and the associated ADCY9 genetic marker. By integrating clinical, biological, and genetic insights, DalCor seeks to address the residual cardiovascular risk in genetically defined patient populations, thereby maximizing therapeutic benefits.

Domain Therapeutics SA is a biopharmaceutical company based in Illkirch-Graffenstaden, France, focused on the discovery and early development of therapeutic drugs targeting G protein-coupled receptors (GPCRs), which are key drug targets in various diseases. Founded in 2001, the company specializes in developing small molecules for the treatment of central nervous system (CNS) disorders and cancer. It employs its proprietary technology platform, DTect-All, which enables the identification of orthosteric and allosteric ligands, including Silent Allosteric Modulators (SAMs) that are challenging to discover using conventional methods. In addition, Domain Therapeutics offers BioSens-All, a platform to explore the signaling complexities associated with GPCR activation, enhancing its ability to address difficult targets, such as orphan and peptidic GPCRs.

Epitopea is a biotechnology company focused on developing innovative immunotherapies for cancer treatment by targeting a new class of tumor-specific antigens. The company employs a proprietary approach that combines immunopeptidomics, mass spectrometry, genomics, and bioinformatics to identify conserved, aberrantly expressed tumor-specific antigens hidden within cancer's non-coding DNA. This technology aims to create therapies that effectively eliminate malignant cells while minimizing damage to healthy tissue, thereby reducing side effects and providing lasting benefits for patients. Research conducted by Drs. Claude Perreault and Pierre Thibault at the Institute for Research in Immunology and Cancer at Université de Montréal has been instrumental in the discovery of these novel antigens, known as Cryptigen™ TSAs, which are shared among patients with the same cancer type.

Phenomic AI Inc. is a biotechnology company based in Toronto, Canada, founded in 2017. The company specializes in developing artificial intelligence solutions to enhance drug discovery and the creation of therapies for cancer. Its innovative platform utilizes AI, computer vision, and high-content screening to analyze phenotypes in complex disease models, such as high-content co-culture and three-dimensional assays. By focusing on the tumor stroma, Phenomic AI aims to optimize the discovery and development of new medicines, streamlining the process for pharmaceutical companies to identify potential drug candidates more effectively.

Find Therapeutics Inc. is a biotechnology company focused on developing therapies for inflammatory and fibrotic rare diseases affecting the airways, liver, and gastrointestinal systems. Founded in 2020 and based in Saint-Laurent, Canada, the company specializes in creating peptide-based therapies and GPCR allosteric modulators aimed at treating autoimmune conditions. Utilizing a peptide discovery engine, Find Therapeutics designs peptides that target critical transmembrane domains of receptors involved in essential biological processes. Through its innovative approach, the company aims to advance next-generation treatments for a range of inflammatory diseases.

Phenomic AI Inc. is a biotechnology company based in Toronto, Canada, founded in 2017. The company specializes in developing artificial intelligence solutions to enhance drug discovery and the creation of therapies for cancer. Its innovative platform utilizes AI, computer vision, and high-content screening to analyze phenotypes in complex disease models, such as high-content co-culture and three-dimensional assays. By focusing on the tumor stroma, Phenomic AI aims to optimize the discovery and development of new medicines, streamlining the process for pharmaceutical companies to identify potential drug candidates more effectively.

Vaxcyte, Inc. is a biotechnology company focused on developing innovative vaccines to prevent and treat infectious diseases globally. The company’s lead candidate, VAX-24, is a 24-valent investigational pneumococcal conjugate vaccine. Additionally, Vaxcyte is advancing VAX-XP, which targets emerging strains that contribute to invasive pneumococcal disease and antibiotic resistance. Other notable candidates include VAX-A1, designed to protect against Group A Streptococcus infections, and VAX-PG, a therapeutic vaccine aimed at treating periodontal disease caused by Porphyromonas gingivalis. Vaxcyte utilizes a proprietary cell-free protein synthesis platform that enables the creation of protein carriers and antigens, enhancing vaccine development beyond conventional methods. Founded in 2013 and headquartered in Foster City, California, the company was previously known as SutroVax, Inc. before rebranding in May 2020.

Phenomic AI Inc. is a biotechnology company based in Toronto, Canada, founded in 2017. The company specializes in developing artificial intelligence solutions to enhance drug discovery and the creation of therapies for cancer. Its innovative platform utilizes AI, computer vision, and high-content screening to analyze phenotypes in complex disease models, such as high-content co-culture and three-dimensional assays. By focusing on the tumor stroma, Phenomic AI aims to optimize the discovery and development of new medicines, streamlining the process for pharmaceutical companies to identify potential drug candidates more effectively.

Visterra, Inc. is a clinical-stage biopharmaceutical company focused on developing precision antibody-based treatments for difficult-to-treat diseases, particularly infectious diseases. Utilizing its Hierotope platform, Visterra designs monoclonal antibodies such as VIS410, aimed at treating hospitalized patients with influenza A, and VIS513 for Dengue fever. The company is also advancing VIS705, an antibody-drug conjugate for Pseudomonas aeruginosa infections, and VIS649, which targets Immunoglobulin A Nephropathy (IgAN). Founded in 2007 and based in Waltham, Massachusetts, Visterra was previously known as Parasol Therapeutics, Inc. The company operates as a subsidiary of Otsuka America, Inc. and emphasizes innovative therapeutic solutions to address significant unmet medical needs.

PreciThera, Inc. is a biotechnology company based in Montreal, Canada, dedicated to developing biological therapeutics for rare bone diseases. Founded in 2016, the company focuses on heterogeneous genetic disorders that primarily lead to bone dysfunction. By leveraging computational technology alongside a comprehensive understanding of disease pathology, PreciThera aims to create targeted therapies that address both skeletal and extraskeletal symptoms in affected patients. The company seeks to enhance treatment options through innovative approaches, including traditional protein replacement therapies, to improve the quality of life for individuals with these rare conditions.

PHEMI Systems Corporation specializes in developing a comprehensive privacy, security, governance, and data management system optimized for Microsoft Azure. Founded in 2013 and based in Vancouver, Canada, the company focuses on the healthcare sector, offering the PHEMI Data Privacy Manager. This cloud-based platform addresses the critical need for healthcare organizations to secure, manage, and control access to sensitive information while ensuring compliance with privacy regulations. Built on a privacy-by-design architecture, PHEMI’s software facilitates data sharing and integrates seamlessly with numerous data sources, as well as popular data science and business analysis tools. The platform is designed to scale according to the organization's size and offers a flexible usage-based pricing model.

Vaxcyte, Inc. is a biotechnology company focused on developing innovative vaccines to prevent and treat infectious diseases globally. The company’s lead candidate, VAX-24, is a 24-valent investigational pneumococcal conjugate vaccine. Additionally, Vaxcyte is advancing VAX-XP, which targets emerging strains that contribute to invasive pneumococcal disease and antibiotic resistance. Other notable candidates include VAX-A1, designed to protect against Group A Streptococcus infections, and VAX-PG, a therapeutic vaccine aimed at treating periodontal disease caused by Porphyromonas gingivalis. Vaxcyte utilizes a proprietary cell-free protein synthesis platform that enables the creation of protein carriers and antigens, enhancing vaccine development beyond conventional methods. Founded in 2013 and headquartered in Foster City, California, the company was previously known as SutroVax, Inc. before rebranding in May 2020.

CellAegis Devices Inc. is a Toronto-based company that develops, manufactures, and commercializes medical devices aimed at enhancing cardiovascular care. Its flagship product, the autoRIC Device, delivers remote ischemic conditioning (RIC) in a non-invasive manner, providing critical therapy to minimize heart damage during heart attacks and various cardiovascular procedures. Additionally, the company offers CRICtrac, a mobile application that enables clinicians to administer self-delivered chronic RIC therapy to patients at home. CellAegis Devices caters to a wide range of settings, including hospitals, ambulances, and home care, and serves markets in Canada, Europe, and the United States.

Ilkos Therapeutic is a company focused on developing an oral compound specifically designed to treat venous lower limb ulcers, a condition primarily affecting older adults. The firm capitalizes on Quebec's strong life sciences sector, leveraging its quality research and development infrastructure alongside available capital to advance new therapeutic solutions. By providing an effective treatment option for this challenging medical issue, Ilkos Therapeutic aims to enhance patient care and improve outcomes for those suffering from venous lower limb ulcers.

IMV Inc. is a clinical-stage biopharmaceutical company based in Dartmouth, Canada, focused on developing innovative cancer immunotherapies and vaccines for infectious diseases. The company utilizes its patented DepoVax platform to enhance immune responses, allowing for controlled and prolonged exposure of antigens. Its lead candidate, DPX-Survivac, is a targeted T cell therapy that has shown promising results in multiple Phase 1 and 1b trials for late-stage ovarian cancer and relapsed/refractory diffuse large B cell lymphoma (DLBCL). IMV is currently conducting Phase 2 trials for DPX-Survivac across several cancer indications and exploring its use in combination with Merck's Keytruda. Additionally, IMV is developing a DPX-based vaccine candidate against COVID-19 and a vaccine targeting the respiratory syncytial virus. The company also has a diverse pipeline of vaccine candidates for various infectious diseases, including malaria and anthrax, and maintains partnerships in the animal health sector.

Visterra, Inc. is a clinical-stage biopharmaceutical company focused on developing precision antibody-based treatments for difficult-to-treat diseases, particularly infectious diseases. Utilizing its Hierotope platform, Visterra designs monoclonal antibodies such as VIS410, aimed at treating hospitalized patients with influenza A, and VIS513 for Dengue fever. The company is also advancing VIS705, an antibody-drug conjugate for Pseudomonas aeruginosa infections, and VIS649, which targets Immunoglobulin A Nephropathy (IgAN). Founded in 2007 and based in Waltham, Massachusetts, Visterra was previously known as Parasol Therapeutics, Inc. The company operates as a subsidiary of Otsuka America, Inc. and emphasizes innovative therapeutic solutions to address significant unmet medical needs.

DalCor Pharmaceuticals is focused on developing precision treatments for cardiovascular disease by targeting specific genetic profiles to enhance clinical outcomes. Its primary program, dalcetrapib, aims to reduce cardiovascular events in patients with a distinct genetic marker. A pharmacogenomic analysis from a significant study indicated that patients with acute coronary syndrome possessing an AA polymorphism in the ADCY9 gene experienced fewer cardiovascular events when treated with dalcetrapib, a CETP inhibitor, compared to those receiving a placebo. The company has secured an exclusive worldwide license from Roche for dalcetrapib and the associated ADCY9 genetic marker. By integrating clinical, biological, and genetic insights, DalCor seeks to address the residual cardiovascular risk in genetically defined patient populations, thereby maximizing therapeutic benefits.

Zymeworks Inc. is a clinical-stage biopharmaceutical company based in Vancouver, Canada, focused on the discovery, development, and commercialization of innovative biotherapeutics for cancer treatment. The company's lead candidates include ZW25, a bispecific antibody undergoing Phase I and II clinical trials for various tumors, including biliary tract and gastroesophageal adenocarcinomas, and ZW49, a bispecific antibody-drug conjugate in Phase I trials for advanced HER2-expressing cancers. Zymeworks employs a computational biotechnology approach, utilizing proprietary molecular modeling and simulation technologies to optimize therapeutic antibodies and other protein-based therapeutics. The company has established strategic partnerships with notable organizations such as Merck, Eli Lilly, and Bristol-Myers Squibb, as well as collaborations aimed at advancing antibody discovery and development. Founded in 2003, Zymeworks is dedicated to addressing unmet medical needs through its advanced therapeutic platforms and integrated drug development capabilities.

PHEMI Systems Corporation specializes in developing a comprehensive privacy, security, governance, and data management system optimized for Microsoft Azure. Founded in 2013 and based in Vancouver, Canada, the company focuses on the healthcare sector, offering the PHEMI Data Privacy Manager. This cloud-based platform addresses the critical need for healthcare organizations to secure, manage, and control access to sensitive information while ensuring compliance with privacy regulations. Built on a privacy-by-design architecture, PHEMI’s software facilitates data sharing and integrates seamlessly with numerous data sources, as well as popular data science and business analysis tools. The platform is designed to scale according to the organization's size and offers a flexible usage-based pricing model.

Vaxcyte, Inc. is a biotechnology company focused on developing innovative vaccines to prevent and treat infectious diseases globally. The company’s lead candidate, VAX-24, is a 24-valent investigational pneumococcal conjugate vaccine. Additionally, Vaxcyte is advancing VAX-XP, which targets emerging strains that contribute to invasive pneumococcal disease and antibiotic resistance. Other notable candidates include VAX-A1, designed to protect against Group A Streptococcus infections, and VAX-PG, a therapeutic vaccine aimed at treating periodontal disease caused by Porphyromonas gingivalis. Vaxcyte utilizes a proprietary cell-free protein synthesis platform that enables the creation of protein carriers and antigens, enhancing vaccine development beyond conventional methods. Founded in 2013 and headquartered in Foster City, California, the company was previously known as SutroVax, Inc. before rebranding in May 2020.

Xagenic Inc. is a Toronto-based molecular diagnostics company focused on developing innovative technology for decentralized and rapid diagnostic testing. The company aims to enhance patient care by enabling on-demand, near-patient molecular testing, which allows clinicians to make informed treatment decisions during the initial consultation. Xagenic's technology facilitates rapid, enzyme-free detection of nucleic acids from clinical samples, yielding results in just 20 minutes. By commercializing a simple and fully automated platform, Xagenic is positioned to revolutionize diagnostic testing by enabling it to be conducted outside of traditional clinical laboratories. The company is also working on tests for infectious diseases that provide clinically actionable results in a timely manner, thereby improving overall healthcare efficiency and reducing costs.

XTuit Pharmaceuticals, Inc. is a biopharmaceutical company focused on developing therapeutics that target the disease-promoting microenvironment associated with fibrotic diseases and cancer. Established in 2011 and based in Waltham, Massachusetts, the company is engaged in creating pharmaceutical preparations aimed at diagnosing and treating oncological, tumor, and inflammatory diseases. XTuit Pharmaceuticals employs novel strategies to enhance cancer therapy by specifically addressing the tumor microenvironment. Its drug development pipeline includes innovative approaches that inhibit extracellular matrix synthesis and stabilize activated stromal cells, utilizing a clinical biomarker platform for effective treatment outcomes.

Profound Medical Corp. is a medical technology company based in Mississauga, Canada, specializing in the development of innovative, incision-free therapeutic systems for the image-guided ablation of diseased tissue. The company’s flagship product, the TULSA-PRO system, integrates real-time magnetic resonance imaging with robotically driven thermal ultrasound to precisely ablate prostate tissue. Additionally, Profound Medical offers the Sonalleve platform, which is designed for treating uterine fibroids and managing palliative pain associated with bone metastases. By leveraging existing MRI infrastructure, the company aims to provide customizable and non-invasive treatment options that address the unmet needs of patients and clinicians. Profound Medical is committed to enhancing the standard of care through its advanced technologies and has established a co-development agreement with GE Healthcare to broaden access to its TULSA-PRO system.

Zymeworks Inc. is a clinical-stage biopharmaceutical company based in Vancouver, Canada, focused on the discovery, development, and commercialization of innovative biotherapeutics for cancer treatment. The company's lead candidates include ZW25, a bispecific antibody undergoing Phase I and II clinical trials for various tumors, including biliary tract and gastroesophageal adenocarcinomas, and ZW49, a bispecific antibody-drug conjugate in Phase I trials for advanced HER2-expressing cancers. Zymeworks employs a computational biotechnology approach, utilizing proprietary molecular modeling and simulation technologies to optimize therapeutic antibodies and other protein-based therapeutics. The company has established strategic partnerships with notable organizations such as Merck, Eli Lilly, and Bristol-Myers Squibb, as well as collaborations aimed at advancing antibody discovery and development. Founded in 2003, Zymeworks is dedicated to addressing unmet medical needs through its advanced therapeutic platforms and integrated drug development capabilities.

Visterra, Inc. is a clinical-stage biopharmaceutical company focused on developing precision antibody-based treatments for difficult-to-treat diseases, particularly infectious diseases. Utilizing its Hierotope platform, Visterra designs monoclonal antibodies such as VIS410, aimed at treating hospitalized patients with influenza A, and VIS513 for Dengue fever. The company is also advancing VIS705, an antibody-drug conjugate for Pseudomonas aeruginosa infections, and VIS649, which targets Immunoglobulin A Nephropathy (IgAN). Founded in 2007 and based in Waltham, Massachusetts, Visterra was previously known as Parasol Therapeutics, Inc. The company operates as a subsidiary of Otsuka America, Inc. and emphasizes innovative therapeutic solutions to address significant unmet medical needs.

GLyPharma Therapeutics, founded in Montréal in August 2012, focuses on developing innovative therapies for rare gastrointestinal diseases, including short bowel syndrome. The company has established a strategic partnership with Ferring Pharmaceuticals, a European firm specializing in peptide development, along with FONDS de solidarité FTQ and CTI Life Sciences Fund. GLyPharma's lead compound, FE 203799, is a long-acting Glucagon-Like Peptide-2 (GLP-2) receptor agonist that exhibits intestine-trophic and protective properties. This compound is being developed under an exclusive worldwide license from Ferring for its potential use in supportive care for oncology patients, specifically aimed at mitigating chemotherapy-induced intestinal mucositis.

Xagenic Inc. is a Toronto-based molecular diagnostics company focused on developing innovative technology for decentralized and rapid diagnostic testing. The company aims to enhance patient care by enabling on-demand, near-patient molecular testing, which allows clinicians to make informed treatment decisions during the initial consultation. Xagenic's technology facilitates rapid, enzyme-free detection of nucleic acids from clinical samples, yielding results in just 20 minutes. By commercializing a simple and fully automated platform, Xagenic is positioned to revolutionize diagnostic testing by enabling it to be conducted outside of traditional clinical laboratories. The company is also working on tests for infectious diseases that provide clinically actionable results in a timely manner, thereby improving overall healthcare efficiency and reducing costs.

Medicago Inc. is a biotechnology company based in Quebec City, Canada, specializing in the research, development, production, and commercialization of vaccines. The company employs proprietary plant-based manufacturing and Virus-Like Particle (VLP) technologies to create innovative vaccines and therapeutics aimed at infectious diseases and public health challenges. Medicago's product pipeline includes a candidate for the H5N1 pandemic influenza VLP vaccine, which has successfully completed a Phase I clinical trial, as well as an H1N1 VLP vaccine and seasonal influenza vaccines. The company has established collaboration agreements with organizations such as Viridis S.A. and Genopole biopark for the manufacturing of its vaccines, and with Philip Morris International to develop a therapeutic protein. Medicago was incorporated in 1997 and continues to focus on addressing emerging health threats through its advanced vaccine technologies.

NeurAxon, Inc. is a Canadian company focused on discovering and developing therapeutics for pain management by targeting neuronal nitric oxide synthase. Founded in 2004 and headquartered in Toronto, NeurAxon is advancing a pipeline of oral products aimed at treating various pain conditions, including acute migraine, neuropathic pain, chronic daily headache, inflammatory pain, migraine prophylaxis, and severe pain. By utilizing selective inhibitors of nitric oxide synthase, the company seeks to provide effective solutions for individuals suffering from these conditions.

Somnus Therapeutics, Inc. is a drug development company focused on creating therapeutics for patients suffering from insomnia. Founded in 2007 and headquartered in Bedminster, New Jersey, the company specializes in developing products that aim to prevent midnight awakenings without causing next-day hangovers. By addressing this common issue, Somnus Therapeutics seeks to facilitate quicker treatment initiation and increase the chances of successful outcomes for insomnia patients.

Chlorion Pharma is a biotechnology start-up focused on developing innovative therapeutics aimed at treating neuropathic pain and epilepsy. The company's approach centers on addressing neuronal hyperactivity by restoring proper chloride homeostasis, which is crucial for normal nerve function. By targeting these underlying mechanisms, Chlorion Pharma aims to provide effective solutions for patients suffering from these debilitating conditions.

Enobia Pharma focuses on developing therapies for serious genetic bone disorders that currently lack approved treatments. The company specifically targets conditions such as hypophosphatasia (HPP), a rare metabolic disorder that affects bone mineralization and can lead to severe skeletal deformities and other health complications. Through its innovative research and development efforts, Enobia aims to provide effective solutions for patients suffering from these debilitating conditions.

TargeGen, Inc. is a biopharmaceutical company based in San Diego, California, that specializes in the discovery and development of small molecule kinase inhibitors targeting vascular leakage, angiogenesis, and inflammation. Founded in 2002, TargeGen focuses on creating treatments for various serious medical conditions, including heart attacks, cancer, and eye diseases. The company's products address issues such as vascular leakage, edema, the abnormal growth of new blood vessels, and conditions like pleural effusions, arthritis, pulmonary edema, transplant ischemia, acute respiratory distress syndrome, brain inflammation, and hypovolemia. TargeGen also serves specific markets related to macular degeneration, diabetic macular edema, and diabetic retinopathy. The company was acquired in 2010, which has further enhanced its capabilities in addressing critical health challenges.