Deerfield Capital

Pleno is a biotechnology company based in San Diego, California, founded in 2017. The company focuses on accelerating disease diagnosis and treatment through its innovative Hypercoding technology, which utilizes signal processing techniques from the telecommunications industry. Pleno has developed a multi-omic instrument for biological target detection that significantly enhances clinical testing and biomedical research. This platform is capable of monitoring minimal residual disease and facilitating early multi-cancer screenings. It also detects a wide array of analytical targets, including DNA, RNA, and protein biomarkers, with exceptional speed and precision. Additionally, Pleno employs advanced microfluidics to automate sample preparation and analysis, thereby providing healthcare providers with diverse health monitoring technologies.

Spectrawave, Inc. is a medical device company based in Waltham, Massachusetts, founded in 2017. The company specializes in developing and manufacturing optical diagnostic and therapeutic devices aimed at enhancing the diagnosis and treatment of cardiovascular diseases. One of its key innovations is a spectroscopy catheter that integrates advanced imaging technologies to improve outcomes for patients with coronary artery disease (CAD). This cutting-edge imaging system provides interventional cardiologists with crucial optical and computational insights, enabling them to identify patients and plaque formations that may pose risks for future coronary complications. Through its focus on photonics, Spectrawave aims to optimize stent interventions and improve overall patient care in the field of cardiovascular medicine.

R3 Vascular specializes in developing and manufacturing innovative medical devices aimed at treating peripheral arterial disease. The company focuses on bioresorbable scaffold technology, specifically creating vascular scaffolds that incorporate a sirolimus coating known for its anti-inflammatory properties. This technology is designed to balance strength and flexibility, enhancing treatment outcomes for patients. One of their notable products, the magnitude BRS device, is recognized as the thinnest bioresorbable scaffold tested in clinical settings, featuring a strut thickness of just 98 microns across various diameters. Through its proprietary polymer technologies, R3 Vascular aims to improve the management of peripheral arterial diseases, particularly in challenging areas such as below the knee.

MMI S.r.l. is an Italian company that specializes in the manufacture and development of advanced micro instruments designed for surgical interventions. Founded in 2015 and based in Calci, Italy, MMI focuses on creating wristed micro instruments and their associated fabrication processes. The company also offers a proprietary robotic platform that enhances the capabilities of these instruments, facilitating complex reconstruction procedures following traumatic injuries and tumor removals in areas such as the breast, head, and bones. MMI aims to support surgeons globally by providing innovative tools that improve surgical outcomes while also reducing costs for patients and healthcare systems.

Reprieve Cardiovascular, Inc. is a medical device company based in Milford, Massachusetts, founded in 2018. The company specializes in developing innovative fluid management technologies aimed at treating congestive heart failure, particularly for patients experiencing acute decompensated heart failure (ADHF). Its flagship product, Reprieve technology, offers a solution that allows clinicians to precisely control and manage a patient's fluid volume, which is crucial for improving cardiac care and facilitating the decongestion of ADHF patients. Reprieve Cardiovascular operates as a subsidiary of CardioRenal Systems, Inc.

Presidio Medical, Inc. is a clinical-stage medical device company based in South San Francisco, California, that focuses on developing a neuromodulation technology platform aimed at treating chronic pain and other disorders affecting neuronal activity. Founded in 2017, the company is dedicated to creating a new class of therapeutic medical devices through its innovative bioelectronic medicine. This platform is designed to provide patients with effective remedies for conditions related to neural activity, positioning Presidio Medical at the forefront of advancements in medtech and bioengineering.

Abeona Therapeutics is a clinical-stage biopharmaceutical company focused on developing gene and cell therapies for life-threatening rare genetic diseases. Its lead programs include EB-101, an autologous, gene-corrected cell therapy for recessive dystrophic epidermolysis bullosa; ABO-102, an adeno-associated virus-based gene therapy for Sanfilippo syndrome type A; and ABO-101, an AAV-based gene therapy for Sanfilippo syndrome type B. The company also develops therapies for Batten disease, cystic fibrosis, and genetic eye disorders. Additionally, Abeona Therapeutics is advancing the AIM Vector Platform, which includes over 100 next-generation AAV capsids for delivering gene therapies to various organs. The company operates a manufacturing facility producing therapies and vectors for preclinical and clinical studies.

Sientra is a medical device company based in Santa Barbara, California, specializing in breast implant treatments for both augmentation and reconstruction. Founded by Hani Zeini, the company develops innovative implantable devices that cater to the needs of plastic surgeons. Sientra's product offerings include silicone gel breast implants, breast tissue expanders, and silicone scar treatment solutions, focusing on providing elegant and intuitive options for cosmetic and reconstructive surgery. The company's commitment to quality and innovation positions it as a significant player in the surgical aesthetics market.

Pleno is a biotechnology company based in San Diego, California, founded in 2017. The company focuses on accelerating disease diagnosis and treatment through its innovative Hypercoding technology, which utilizes signal processing techniques from the telecommunications industry. Pleno has developed a multi-omic instrument for biological target detection that significantly enhances clinical testing and biomedical research. This platform is capable of monitoring minimal residual disease and facilitating early multi-cancer screenings. It also detects a wide array of analytical targets, including DNA, RNA, and protein biomarkers, with exceptional speed and precision. Additionally, Pleno employs advanced microfluidics to automate sample preparation and analysis, thereby providing healthcare providers with diverse health monitoring technologies.

MMI S.r.l. is an Italian company that specializes in the manufacture and development of advanced micro instruments designed for surgical interventions. Founded in 2015 and based in Calci, Italy, MMI focuses on creating wristed micro instruments and their associated fabrication processes. The company also offers a proprietary robotic platform that enhances the capabilities of these instruments, facilitating complex reconstruction procedures following traumatic injuries and tumor removals in areas such as the breast, head, and bones. MMI aims to support surgeons globally by providing innovative tools that improve surgical outcomes while also reducing costs for patients and healthcare systems.

Acutus Medical, Inc. is an arrhythmia management company specializing in the development of medical technologies for the diagnosis and treatment of complex cardiac arrhythmias. Founded in 2011 and headquartered in Carlsbad, California, the company designs, manufactures, and markets a comprehensive range of tools for catheter-based ablation procedures. Its product portfolio includes advanced imaging and navigation systems, such as the AcQMap console and workstation, alongside various diagnostic and therapeutic devices like mapping and ablation catheters. Acutus Medical's innovative platform enables electrophysiologists to visualize the heart's activation patterns, facilitating more effective treatment strategies. The company collaborates with medical scientists and engineers in both the U.S. and Europe to enhance its offerings. Acutus Medical markets its products worldwide, primarily targeting hospitals and electrophysiologists engaged in arrhythmia care.

Hyperfine is a medical device company that developed Swoop, the first FDA-cleared point-of-care MRI system designed to enhance patient access to diagnostic imaging. Swoop operates at a lower magnetic field strength than traditional MRI machines, producing high-quality images quickly and efficiently. This portable system can be easily wheeled to a patient's bedside, plugged into a standard electrical outlet, and operated via an iPad, making it suitable for various clinical environments such as emergency departments and intensive care units. Hyperfine generates revenue through the sale of MRI devices and service sales, which include subscriptions for bundled devices, maintenance, and software. By providing rapid imaging capabilities at a fraction of the cost of conventional MRIs, Hyperfine aims to facilitate timely diagnoses and treatments for patients, regardless of their location or resources.

V-Wave Ltd. is a private company that develops percutaneous implantable therapeutic devices for patients suffering from chronic heart failure. Founded in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave has created a proprietary interatrial shunt designed to alleviate symptoms associated with both preserved and reduced ejection fraction heart failure. This biocompatible implant regulates left atrial pressure, addressing a key factor in the deterioration of heart failure. The device aims to enhance patients' quality of life by reducing hospitalizations and improving exercise capacity. V-Wave's team consists of experienced engineers and medical scientists dedicated to advancing treatment options for individuals who continue to experience debilitating symptoms despite optimal medical care.

Strata Oncology, Inc. is a precision oncology company focused on improving cancer care by increasing patient access to clinical trials and expediting drug approvals. The company operates a national precision oncology platform that connects patient screening to streamlined enrollment in mutation-matched clinical trials. Strata collaborates with major healthcare systems to facilitate the genomic sequencing of cancer patients' biopsies in high-throughput laboratories, providing oncologists with timely tumor profiles that inform treatment decisions. Its offerings include The Strata Trial, StrataNGS for targeted DNA and RNA sequencing, and StrataPOINT, which integrates electronic medical records with molecular data to ensure comprehensive testing and follow-up for eligible patients. Strata also manages a portfolio of pharmaceutical-sponsored trials tailored to specific biomarkers and operates the Strata Precision Oncology Network, a collaborative effort among cancer centers to advance precision medicine. Founded in 2015 and headquartered in Ann Arbor, Michigan, Strata was previously known as Strata Oncology Research, Inc. until its name change in May 2016.

Spectrawave, Inc. is a medical device company based in Waltham, Massachusetts, founded in 2017. The company specializes in developing and manufacturing optical diagnostic and therapeutic devices aimed at enhancing the diagnosis and treatment of cardiovascular diseases. One of its key innovations is a spectroscopy catheter that integrates advanced imaging technologies to improve outcomes for patients with coronary artery disease (CAD). This cutting-edge imaging system provides interventional cardiologists with crucial optical and computational insights, enabling them to identify patients and plaque formations that may pose risks for future coronary complications. Through its focus on photonics, Spectrawave aims to optimize stent interventions and improve overall patient care in the field of cardiovascular medicine.

MIVI Neuroscience, Inc. is a medical device company based in Eden Prairie, Minnesota, that specializes in developing and commercializing solutions for neurointerventional procedures. Founded in 2013, the company offers a range of innovative products designed to enhance patient outcomes by improving the safety and efficacy of treatments for ischemic stroke. Its product portfolio includes high flow tubing, diagnostic and guide catheters, and aspiration pumps, as well as embolic protection and clot retrieval devices. MIVI Neuroscience aims to reduce complications and procedure times, thereby expanding treatment options for healthcare professionals and their patients.

V-Wave Ltd. is a private company that develops percutaneous implantable therapeutic devices for patients suffering from chronic heart failure. Founded in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave has created a proprietary interatrial shunt designed to alleviate symptoms associated with both preserved and reduced ejection fraction heart failure. This biocompatible implant regulates left atrial pressure, addressing a key factor in the deterioration of heart failure. The device aims to enhance patients' quality of life by reducing hospitalizations and improving exercise capacity. V-Wave's team consists of experienced engineers and medical scientists dedicated to advancing treatment options for individuals who continue to experience debilitating symptoms despite optimal medical care.

Reprieve Cardiovascular, Inc. is a medical device company based in Milford, Massachusetts, founded in 2018. The company specializes in developing innovative fluid management technologies aimed at treating congestive heart failure, particularly for patients experiencing acute decompensated heart failure (ADHF). Its flagship product, Reprieve technology, offers a solution that allows clinicians to precisely control and manage a patient's fluid volume, which is crucial for improving cardiac care and facilitating the decongestion of ADHF patients. Reprieve Cardiovascular operates as a subsidiary of CardioRenal Systems, Inc.

Liquid Wire Inc. specializes in the design and manufacture of liquid metal circuits, utilizing non-toxic printable liquid metals applied to plastic and textile substrates. Founded in 2016 and based in Beaverton, Oregon, the company focuses on creating dynamically stretchable and flexible electronics. Its proprietary Metal Gel circuits are specifically developed for performance apparel and medical wearables, ensuring comfort and durability while maintaining high pliability. Liquid Wire's gallium-based circuitry operates at room temperature and is self-healing, making it highly conductive and suitable for integrating wearable sensors and power transmission into various textile materials. This innovative approach positions Liquid Wire at the forefront of the emerging market for softer and more flexible electronics.

AdaptHealth is a provider of patient-centered healthcare-at-home solutions, specializing in home medical equipment (HME), medical supplies, and associated services. The company distributes a wide range of clinically driven products designed to support patients in living independently, including sleep and respiratory therapy equipment, mobility aids, wound care supplies, and nutrition services. AdaptHealth also offers vital services such as continuous glucose monitoring and insulin pumps for diabetes management, as well as oxygen and chronic therapy services. Founded in 2012 and headquartered in Phoenixville, Pennsylvania, the company serves patients and healthcare institutions across several states, including Pennsylvania, New Jersey, New York, Maryland, and Delaware. Additionally, AdaptHealth provides online bill payment services to assist patients in managing their medical equipment expenses.

Meditrina, Inc. is a medical device company based in San Jose, California, specializing in tissue removal solutions for intrauterine pathology. Founded in 2016, the company has developed the Aveta System, an all-in-one solution designed for hysteroscopic diagnostic and therapeutic procedures. This system enables healthcare professionals to perform tasks such as the removal of polyps and fibroids in both office and operating room settings. The Aveta System features wide-angle HD hysteroscopy with electronic image-lock, advanced fluid management for better pressure and fluid control, and a compact design that allows for seamless integration into various medical environments. By providing advanced, convenient, and cost-effective options, Meditrina aims to enhance the care experience for both patients and physicians.

CorVent Medical, Inc., established in 2020 and headquartered in New York, specializes in developing and manufacturing ventilators for critical care applications. Its flagship product, the RESPOND Ventilator, is a compact, single-use device designed to meet a wide range of patient respiratory needs. Weighing 15 pounds (7 kg), it is easy to deploy and has been tested to meet international ICU ventilation standards. The RESPOND Ventilator is designed for maintenance-free use, ensuring reliability and a long shelf life, thereby reducing total cost of ownership. Additionally, CorVent offers ventilator tubing connectors and accessories to complement its core product offerings.

Intersect ENT, Inc. is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions. Founded in 2003 and headquartered in Menlo Park, California, the company specializes in drug delivery products aimed at enhancing treatment outcomes for chronic sinusitis and other related ailments. Its key offerings include the PROPEL and PROPEL mini drug-releasing implants, designed for patients undergoing sinus surgery, as well as the PROPEL Contour implant, which targets frontal and maxillary sinus ostia. Additionally, Intersect ENT provides SINUVA, a steroid-releasing implant intended for use in a physician office setting to address refractory disease. The company was previously known as Sinexus, Inc. before rebranding in 2009.

LetsGetChecked is a healthcare technology company that facilitates at-home health testing. It connects users with regulated laboratories worldwide for various tests, including general wellness, sexual health, women's health, men's health, and COVID-19. Users collect samples at home using provided kits and mail them back for analysis; results are then accessible online. The platform aims to empower individuals to proactively manage their health, offering services across the United States, Canada, and Europe.

Element Science, Inc. is a medical device and digital health company focused on developing solutions for high-risk cardiovascular patients. The company's flagship product is a patch-based wearable cardioverter defibrillator that continuously monitors heart activity to protect against sudden cardiac death. This device integrates advanced data science and machine learning algorithms with strict electromechanical medical device standards, creating a proprietary digital platform that enhances patient care as individuals transition from hospital to home. Founded in 2011 and headquartered in San Francisco, California, Element Science aims to address critical health needs and reduce hospitalization rates associated with heart disease. The company was previously known as Revive Defibrillation Systems, Inc. before adopting its current name in 2014.

Farapulse, Inc. develops and commercializes catheter-based tools specifically designed for the treatment of atrial fibrillation. Founded in 2012 and based in Menlo Park, California, the company offers an innovative product known as FARAWAVE, which utilizes advanced tissue-selective pulsed field ablation (PFA) therapy. This therapy is available on both catheter and surgical platforms for endocardial and epicardial applications. Farapulse's product range includes various catheter types, such as over-the-wire, deflectable, linear, and circumferential lesion catheters, which enable doctors to isolate pulmonary veins safely and effectively. The company's mission is to enhance the safety, speed, accessibility, and affordability of atrial fibrillation ablation for patients worldwide.

AdaptHealth is a provider of patient-centered healthcare-at-home solutions, specializing in home medical equipment (HME), medical supplies, and associated services. The company distributes a wide range of clinically driven products designed to support patients in living independently, including sleep and respiratory therapy equipment, mobility aids, wound care supplies, and nutrition services. AdaptHealth also offers vital services such as continuous glucose monitoring and insulin pumps for diabetes management, as well as oxygen and chronic therapy services. Founded in 2012 and headquartered in Phoenixville, Pennsylvania, the company serves patients and healthcare institutions across several states, including Pennsylvania, New Jersey, New York, Maryland, and Delaware. Additionally, AdaptHealth provides online bill payment services to assist patients in managing their medical equipment expenses.

Graybug Vision, Inc. is a clinical-stage biopharmaceutical company dedicated to developing innovative treatments for diseases affecting the retina and optic nerve. Founded in 2011 and based in Redwood City, California, the company focuses on chronic vision-threatening conditions. Its lead product candidate, GB-102, is an intravitreal injection undergoing clinical trials for wet age-related macular degeneration and diabetic macular edema. Additionally, Graybug is advancing GB-103, a once-a-year formulation aimed at treating diabetic retinopathy, and GB-401, a depot formulation targeting primary open-angle glaucoma. The company utilizes proprietary micro- and nanoparticle controlled release technologies to enhance drug delivery in ocular tissues, thereby improving patient compliance and clinical outcomes. Graybug Vision was previously known as Graybug LLC before its rebranding in 2016.

Axon Therapies specializes in developing innovative healthcare devices aimed at addressing heart failure by targeting the sympathetic nervous system. The company's primary offering is the SAVM procedure, which employs a small catheter inserted through the groin to ablate the right greater splanchnic nerve. This technique effectively reduces sympathetic nerve activity, helping to restore balance in the circulatory system. By shifting blood volume from the heart to the splanchnic bed, it alleviates pressure in the heart, thereby enhancing treatment efficacy. Clinicians can utilize this approach to initiate patient care rapidly, increasing the likelihood of successful outcomes.

Acutus Medical, Inc. is an arrhythmia management company specializing in the development of medical technologies for the diagnosis and treatment of complex cardiac arrhythmias. Founded in 2011 and headquartered in Carlsbad, California, the company designs, manufactures, and markets a comprehensive range of tools for catheter-based ablation procedures. Its product portfolio includes advanced imaging and navigation systems, such as the AcQMap console and workstation, alongside various diagnostic and therapeutic devices like mapping and ablation catheters. Acutus Medical's innovative platform enables electrophysiologists to visualize the heart's activation patterns, facilitating more effective treatment strategies. The company collaborates with medical scientists and engineers in both the U.S. and Europe to enhance its offerings. Acutus Medical markets its products worldwide, primarily targeting hospitals and electrophysiologists engaged in arrhythmia care.

Acutus Medical, Inc. is an arrhythmia management company specializing in the development of medical technologies for the diagnosis and treatment of complex cardiac arrhythmias. Founded in 2011 and headquartered in Carlsbad, California, the company designs, manufactures, and markets a comprehensive range of tools for catheter-based ablation procedures. Its product portfolio includes advanced imaging and navigation systems, such as the AcQMap console and workstation, alongside various diagnostic and therapeutic devices like mapping and ablation catheters. Acutus Medical's innovative platform enables electrophysiologists to visualize the heart's activation patterns, facilitating more effective treatment strategies. The company collaborates with medical scientists and engineers in both the U.S. and Europe to enhance its offerings. Acutus Medical markets its products worldwide, primarily targeting hospitals and electrophysiologists engaged in arrhythmia care.

CathWorks Ltd. is a medical technology company that specializes in enhancing percutaneous coronary intervention (PCI) therapy decisions through its advanced computational science platform. Founded in 2013 and headquartered in Kfar-Saba, Israel, with an additional office in the United States, the company has developed the CathWorks FFRangio, a non-invasive device that provides objective, multi-vessel physiologic measurements. This tool transforms coronary angiography from a subjective visual assessment into an objective decision-making framework based on fractional flow reserve (FFR) metrics. By utilizing sophisticated algorithms to process visual information, CathWorks aims to improve the efficiency of cath lab operations and support healthcare providers in making data-driven clinical decisions.

Itamar Medical Ltd. is a medical device company based in Caesarea, Israel, specializing in the research, development, marketing, and sale of non-invasive medical devices for the cardiology market. Founded in 1997, the company utilizes its proprietary Peripheral Arterial Tone (PAT) signal technology to create devices that assess various cardiovascular and respiratory conditions. Its flagship products include the WatchPAT device, which facilitates home testing for sleep disorders such as obstructive sleep apnea, and the EndoPAT device, which is designed to diagnose endothelial dysfunction and evaluate the risk of coronary artery disease. Itamar Medical operates across multiple regions, including the United States, Europe, Canada, Japan, and the Asia Pacific. The company also collaborates with SoClean Inc. to enhance the distribution of its home sleep apnea test and digital health services through direct-to-consumer channels.

PQ Bypass, Inc. is a medical device company based in Milpitas, California, that specializes in developing innovative solutions for the treatment of peripheral vascular disease through minimally invasive procedures. Founded in 2009, the company focuses on addressing long-segment femoropopliteal disease with its advanced products, including the DETOUR System, PQ Snare, PQ Crossing Device, and TORUS Stent Graft System. PQ Bypass aims to transform the treatment landscape for peripheral artery disease by providing effective endovascular solutions. The executive team brings extensive experience from leading firms in the medical device sector, enhancing the company's ability to innovate and deliver impactful medical technologies.

NeoChord, Inc. is a medical technology company based in St. Louis Park, Minnesota, that focuses on developing innovative devices for the treatment of degenerative mitral valve disease (DMR). Founded in 2007, the company has created the NeoChord Artificial Chordae Delivery System, a disposable device designed for minimally invasive mitral valve repair. This system allows surgeons to replace damaged chordae through a small incision of 2 to 3 inches between the ribs, enabling the procedure to be performed on a beating heart. This approach contrasts sharply with traditional methods, which typically involve larger incisions and stopping the heart, thus reducing recovery time and associated complications. NeoChord's technology aims to improve surgical outcomes for patients suffering from severe mitral regurgitation, which can lead to serious conditions such as atrial fibrillation and congestive heart failure.

Orchard Therapeutics is a biopharmaceutical company based in London, focused on developing innovative gene therapies for serious and life-threatening rare diseases. The company employs an autologous ex vivo gene therapy approach, which aims to modify a patient's hematopoietic stem cells to create a personalized treatment through a single administration. Orchard's product portfolio includes Strimvelis, the first gene therapy approved by the European Medicines Agency for adenosine deaminase-severe combined immunodeficiency (ADA-SCID). The company is advancing several clinical programs, including OTL-101 for ADA-SCID, OTL-200 for metachromatic leukodystrophy, OTL-103 for Wiskott-Aldrich syndrome, OTL-102 for X-linked chronic granulomatous disease, and OTL-300 for transfusion-dependent beta-thalassemia. Additionally, Orchard has a robust preclinical pipeline targeting various mucopolysaccharidosis types. Founded in 2015, Orchard Therapeutics collaborates with leading institutions in the field to enhance its research and development efforts.

MedAvail Holdings, Inc. is a technology-enabled pharmacy company based in Mississauga, Canada, specializing in the integration of automated pharmacy services within clinics and other healthcare settings. The company operates primarily through two segments: Retail Pharmacy Services and Pharmacy Technology. Its Retail Pharmacy Services segment generates most of its revenue by operating SpotRx, a full-service retail pharmacy that utilizes MedAvail's automated technology, primarily serving Medicare patients in the United States. The Pharmacy Technology segment focuses on the development and commercialization of the MedAvail MedCenter, an advanced robotic dispensing platform that can be sold or leased to third-party clients. Additionally, MedAvail offers telehealth solutions, enabling remote consultations with pharmacists via on-site kiosks and home delivery services.

Strata Oncology, Inc. is a precision oncology company focused on improving cancer care by increasing patient access to clinical trials and expediting drug approvals. The company operates a national precision oncology platform that connects patient screening to streamlined enrollment in mutation-matched clinical trials. Strata collaborates with major healthcare systems to facilitate the genomic sequencing of cancer patients' biopsies in high-throughput laboratories, providing oncologists with timely tumor profiles that inform treatment decisions. Its offerings include The Strata Trial, StrataNGS for targeted DNA and RNA sequencing, and StrataPOINT, which integrates electronic medical records with molecular data to ensure comprehensive testing and follow-up for eligible patients. Strata also manages a portfolio of pharmaceutical-sponsored trials tailored to specific biomarkers and operates the Strata Precision Oncology Network, a collaborative effort among cancer centers to advance precision medicine. Founded in 2015 and headquartered in Ann Arbor, Michigan, Strata was previously known as Strata Oncology Research, Inc. until its name change in May 2016.

V-Wave Ltd. is a private company that develops percutaneous implantable therapeutic devices for patients suffering from chronic heart failure. Founded in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave has created a proprietary interatrial shunt designed to alleviate symptoms associated with both preserved and reduced ejection fraction heart failure. This biocompatible implant regulates left atrial pressure, addressing a key factor in the deterioration of heart failure. The device aims to enhance patients' quality of life by reducing hospitalizations and improving exercise capacity. V-Wave's team consists of experienced engineers and medical scientists dedicated to advancing treatment options for individuals who continue to experience debilitating symptoms despite optimal medical care.

Fractyl Health, based in Lexington, Massachusetts, specializes in developing innovative medical device solutions for metabolic diseases, particularly type 2 diabetes and obesity. The company’s primary offering, Revita DMR, is a minimally invasive therapy that utilizes hydrothermal ablation to rejuvenate the duodenal lining, which can become compromised due to high-fat and high-sugar diets. By focusing on durable disease-modifying therapies rather than just symptomatic management, Fractyl Health aims to address the underlying causes of metabolic diseases, improving patient outcomes and reducing healthcare burdens. Founded in 2010 and originally named MedCatalyst, Inc., the company envisions a future where less invasive, device-based therapies provide effective solutions for large populations affected by metabolic disorders.

Phoenix, LLC specializes in designing and manufacturing advanced nuclear and particle accelerator technologies, with a focus on high-yield neutron generators. These generators serve diverse applications, including neutron radiography, cargo screening, explosives detection, special nuclear material detection, and medical isotope production. The company also produces compact neutron generators used for nuclear fuel scanning and fast neutron radiography. Founded in 2005 and located in Madison, Wisconsin, Phoenix aims to commercialize nuclear technologies for practical uses across various sectors, including aerospace, defense, medical, and semiconductor industries. Additionally, the company is committed to its long-term vision of developing clean fusion energy solutions.

MIVI Neuroscience, Inc. is a medical device company based in Eden Prairie, Minnesota, that specializes in developing and commercializing solutions for neurointerventional procedures. Founded in 2013, the company offers a range of innovative products designed to enhance patient outcomes by improving the safety and efficacy of treatments for ischemic stroke. Its product portfolio includes high flow tubing, diagnostic and guide catheters, and aspiration pumps, as well as embolic protection and clot retrieval devices. MIVI Neuroscience aims to reduce complications and procedure times, thereby expanding treatment options for healthcare professionals and their patients.

Farapulse, Inc. develops and commercializes catheter-based tools specifically designed for the treatment of atrial fibrillation. Founded in 2012 and based in Menlo Park, California, the company offers an innovative product known as FARAWAVE, which utilizes advanced tissue-selective pulsed field ablation (PFA) therapy. This therapy is available on both catheter and surgical platforms for endocardial and epicardial applications. Farapulse's product range includes various catheter types, such as over-the-wire, deflectable, linear, and circumferential lesion catheters, which enable doctors to isolate pulmonary veins safely and effectively. The company's mission is to enhance the safety, speed, accessibility, and affordability of atrial fibrillation ablation for patients worldwide.

Elutia is a commercial-stage regenerative medicine company dedicated to developing innovative products aimed at enhancing patient outcomes during surgical procedures, particularly for those receiving implantable medical devices. The company focuses on several key areas, including Device Protection, Women's Health, and Cardiovascular health, with the Women's Health segment generating the highest revenue. Utilizing proprietary tissue processing platforms, Elutia has created a range of advanced regenerative medical products that closely resemble natural biological materials. These products are designed to address unmet clinical needs by promoting healthy tissue formation and minimizing complications commonly associated with medical device implants, such as scar tissue formation and capsular contraction.

SteadyMed Therapeutics, Inc. is a specialty pharmaceutical company focused on developing and commercializing innovative therapeutic products for pain relief and chronic conditions. The company is known for its PatchPump, a customizable, pre-filled, and pre-programmed disposable delivery platform designed for large volume and viscous formulations. Key offerings include Trevyent, a single-use PatchPump pre-filled with treprostinil for treating pulmonary arterial hypertension, and SMT-201, which enables subcutaneous delivery of Ketorolac, a non-steroidal anti-inflammatory drug. Additionally, SMT-301 delivers bupivacaine directly into surgical wounds for effective local pain relief. Founded in 2005 and headquartered in San Ramon, California, with a research and development center in Rehovot, Israel, SteadyMed operates as a subsidiary of United Therapeutics Corporation. The company collaborates with pharmaceutical and device partners to tailor applications of its drug-infusion patches to meet specific therapeutic needs.

Endologix, Inc. is a medical device company that specializes in developing, manufacturing, marketing, and selling innovative solutions for the treatment of abdominal aortic aneurysms (AAA) both in the United States and internationally. The company offers a range of minimally invasive endovascular aneurysm repair (EVAR) products, including the AFX Endovascular AAA System, VELA Proximal Endograft, and Ovation abdominal stent graft system. Additionally, Endologix provides an endovascular aneurysm sealing (EVAS) system designed to seal aneurysms while maintaining blood flow to the legs. Their product offerings also include various extensions and accessories to tailor treatments to individual patient anatomies. Founded in 1992 and headquartered in Irvine, California, Endologix has a direct sales force as well as a network of third-party distributors and agents to market its products. The company was previously known as Radiance Medical Systems, Inc. until its name change in May 2002.

ShockWave Medical, Inc. is a medical device company based in Santa Clara, California, focused on developing and commercializing intravascular lithotripsy technology to treat calcified plaque associated with peripheral vascular, coronary vascular, and heart valve diseases. The company offers a range of catheters, including M5 for above-the-knee peripheral artery disease, C2 for coronary artery disease, and S4 for below-the-knee peripheral artery disease. Its Lithoplasty™ technology utilizes sonic pressure waves to facilitate the treatment of rigid vascular and valvular lesions, allowing for improved angioplasty outcomes and reduced reliance on stents. This innovative approach enhances vessel preparation before procedures such as drug eluting balloon placement and trans-catheter aortic valve replacement. ShockWave Medical serves a diverse clientele, including interventional cardiologists, vascular surgeons, and interventional radiologists, through a network of sales representatives, managers, and distributors across the United States and Europe. Incorporated in 2009, the company is committed to transforming cardiovascular care and improving patient outcomes.

SentreHEART, Inc., located in Redwood City, California, is a privately held medical device company specializing in innovative catheter-based technologies for suturing soft tissues. The company has developed the LARIAT Suture Delivery Device, which allows physicians to remotely deliver a pre-tied 40mm suture loop for effective soft tissue closure through access points as small as 4.3mm, without leaving behind any metal, clips, or fabrics. This technology is designed to enhance patient safety by reducing the risk of thromboembolism. SentreHEART has obtained regulatory clearance for its devices for soft tissue ligation and approximation in the United States, Europe, and Canada.

SteadyMed Therapeutics, Inc. is a specialty pharmaceutical company focused on developing and commercializing innovative therapeutic products for pain relief and chronic conditions. The company is known for its PatchPump, a customizable, pre-filled, and pre-programmed disposable delivery platform designed for large volume and viscous formulations. Key offerings include Trevyent, a single-use PatchPump pre-filled with treprostinil for treating pulmonary arterial hypertension, and SMT-201, which enables subcutaneous delivery of Ketorolac, a non-steroidal anti-inflammatory drug. Additionally, SMT-301 delivers bupivacaine directly into surgical wounds for effective local pain relief. Founded in 2005 and headquartered in San Ramon, California, with a research and development center in Rehovot, Israel, SteadyMed operates as a subsidiary of United Therapeutics Corporation. The company collaborates with pharmaceutical and device partners to tailor applications of its drug-infusion patches to meet specific therapeutic needs.

Graybug Vision, Inc. is a clinical-stage biopharmaceutical company dedicated to developing innovative treatments for diseases affecting the retina and optic nerve. Founded in 2011 and based in Redwood City, California, the company focuses on chronic vision-threatening conditions. Its lead product candidate, GB-102, is an intravitreal injection undergoing clinical trials for wet age-related macular degeneration and diabetic macular edema. Additionally, Graybug is advancing GB-103, a once-a-year formulation aimed at treating diabetic retinopathy, and GB-401, a depot formulation targeting primary open-angle glaucoma. The company utilizes proprietary micro- and nanoparticle controlled release technologies to enhance drug delivery in ocular tissues, thereby improving patient compliance and clinical outcomes. Graybug Vision was previously known as Graybug LLC before its rebranding in 2016.

Acutus Medical, Inc. is an arrhythmia management company specializing in the development of medical technologies for the diagnosis and treatment of complex cardiac arrhythmias. Founded in 2011 and headquartered in Carlsbad, California, the company designs, manufactures, and markets a comprehensive range of tools for catheter-based ablation procedures. Its product portfolio includes advanced imaging and navigation systems, such as the AcQMap console and workstation, alongside various diagnostic and therapeutic devices like mapping and ablation catheters. Acutus Medical's innovative platform enables electrophysiologists to visualize the heart's activation patterns, facilitating more effective treatment strategies. The company collaborates with medical scientists and engineers in both the U.S. and Europe to enhance its offerings. Acutus Medical markets its products worldwide, primarily targeting hospitals and electrophysiologists engaged in arrhythmia care.

Advantia Health, LLC is a healthcare delivery company based in Arlington, Virginia, founded in 2014. It specializes in providing comprehensive services in obstetrics and gynecology, primary care, and mental wellness, primarily focused on women's health and that of their families. The company operates additional locations in Virginia, Maryland, Illinois, and Missouri. Advantia Health utilizes technology to deliver high-quality, efficient care through outpatient facilities and offers telehealth services, enabling patients to connect with healthcare providers via web and mobile applications. This approach ensures that patients receive timely and appropriate medical guidance tailored to their needs.

Fractyl Health, based in Lexington, Massachusetts, specializes in developing innovative medical device solutions for metabolic diseases, particularly type 2 diabetes and obesity. The company’s primary offering, Revita DMR, is a minimally invasive therapy that utilizes hydrothermal ablation to rejuvenate the duodenal lining, which can become compromised due to high-fat and high-sugar diets. By focusing on durable disease-modifying therapies rather than just symptomatic management, Fractyl Health aims to address the underlying causes of metabolic diseases, improving patient outcomes and reducing healthcare burdens. Founded in 2010 and originally named MedCatalyst, Inc., the company envisions a future where less invasive, device-based therapies provide effective solutions for large populations affected by metabolic disorders.

NeoChord, Inc. is a medical technology company based in St. Louis Park, Minnesota, that focuses on developing innovative devices for the treatment of degenerative mitral valve disease (DMR). Founded in 2007, the company has created the NeoChord Artificial Chordae Delivery System, a disposable device designed for minimally invasive mitral valve repair. This system allows surgeons to replace damaged chordae through a small incision of 2 to 3 inches between the ribs, enabling the procedure to be performed on a beating heart. This approach contrasts sharply with traditional methods, which typically involve larger incisions and stopping the heart, thus reducing recovery time and associated complications. NeoChord's technology aims to improve surgical outcomes for patients suffering from severe mitral regurgitation, which can lead to serious conditions such as atrial fibrillation and congestive heart failure.

EndoChoice is a medical technology company specializing in the design and commercialization of products and services for gastrointestinal (GI) care. Headquartered in Alpharetta, Georgia, EndoChoice offers a comprehensive range of products, including single-use devices, infection control solutions, diagnostics, and advanced imaging systems. The company's proprietary product portfolio features the Full Spectrum Endoscopy™ System, known as Fuse™, which includes colonoscopes and gastroscopes equipped with multiple imagers. This innovative system enables physicians to achieve a 330-degree field of view, significantly improving the detection of polyps compared to traditional endoscopes. With a direct sales organization serving over 2,000 customers in the United States and partnerships with 34 distributors globally, EndoChoice has established a strong presence in the market. Founded in 2008, the company experienced rapid growth and was recognized by Inc. Magazine as one of the fastest-growing companies in the U.S. before its acquisition by Boston Scientific in 2016.

SteadyMed Therapeutics, Inc. is a specialty pharmaceutical company focused on developing and commercializing innovative therapeutic products for pain relief and chronic conditions. The company is known for its PatchPump, a customizable, pre-filled, and pre-programmed disposable delivery platform designed for large volume and viscous formulations. Key offerings include Trevyent, a single-use PatchPump pre-filled with treprostinil for treating pulmonary arterial hypertension, and SMT-201, which enables subcutaneous delivery of Ketorolac, a non-steroidal anti-inflammatory drug. Additionally, SMT-301 delivers bupivacaine directly into surgical wounds for effective local pain relief. Founded in 2005 and headquartered in San Ramon, California, with a research and development center in Rehovot, Israel, SteadyMed operates as a subsidiary of United Therapeutics Corporation. The company collaborates with pharmaceutical and device partners to tailor applications of its drug-infusion patches to meet specific therapeutic needs.

Breathe Technologies, Inc. is a medical technology company based in Irvine, California, that specializes in developing and manufacturing innovative respiratory therapies for treating respiratory insufficiency diseases. Founded in 2005, the company focuses on creating non-invasive open ventilation systems aimed at helping patients with conditions such as interstitial lung diseases, neuromuscular disorders, and those undergoing lung transplants. Their lightweight, volume-control mechanical ventilators are designed to enhance patient mobility and are suitable for use in various healthcare settings, including general medical units, intensive care, and pulmonary rehabilitation. As a subsidiary of Hill-Rom, Breathe Technologies is committed to providing reliable and accessible solutions that optimize breathing and improve the quality of life for patients both in hospital and home environments.

MedAvail Holdings, Inc. is a technology-enabled pharmacy company based in Mississauga, Canada, specializing in the integration of automated pharmacy services within clinics and other healthcare settings. The company operates primarily through two segments: Retail Pharmacy Services and Pharmacy Technology. Its Retail Pharmacy Services segment generates most of its revenue by operating SpotRx, a full-service retail pharmacy that utilizes MedAvail's automated technology, primarily serving Medicare patients in the United States. The Pharmacy Technology segment focuses on the development and commercialization of the MedAvail MedCenter, an advanced robotic dispensing platform that can be sold or leased to third-party clients. Additionally, MedAvail offers telehealth solutions, enabling remote consultations with pharmacists via on-site kiosks and home delivery services.

Alphatec Spine, Inc. is a medical technology company specializing in surgical solutions for spine disorders, particularly those affecting the aging population. Founded in 1990 and headquartered in Carlsbad, California, the company designs, develops, and manufactures a comprehensive range of products. Its offerings include various spinal fixation systems, interbody fusion products, and biologics such as amniotic tissue barriers and osteoconductive scaffolds. Alphatec Spine also features minimally invasive solutions and specialized devices for treating thoracolumbar and cervicothoracic conditions. The company's products are primarily marketed in the United States and distributed through a direct sales force in select European countries, as well as through independent distributors globally. With an emphasis on innovative technologies and treatment options, Alphatec Spine strives to enhance surgical outcomes for patients with spine-related issues.

TriVascular Technologies, Inc. is a medical device company focused on developing and commercializing technologies for the minimally invasive treatment of abdominal aortic aneurysms (AAA) and thoracic aortic conditions. The company is known for its Ovation System, which includes a stent graft platform designed for endovascular aortic repair. Key components of the Ovation System feature an aortic body, iliac limbs, and polymer fill, which contribute to its effectiveness in treating AAA. TriVascular markets its products through direct sales in the United States and several European countries, as well as via distributors in other regions. Founded in 2007 and headquartered in Santa Rosa, California, TriVascular has been recognized for its innovative approach to addressing unmet clinical needs in aortic disease treatment. The company operates as a subsidiary of Endologix Inc.

IMRIS is a company that designs, manufactures, and markets image-guided therapy systems aimed at enhancing the effectiveness of medical treatments. Its primary product, the VISIUS Surgical Theatre, integrates advanced imaging technologies such as magnetic resonance imaging, computed tomography, and fluoroscopy into multi-purpose surgical suites. This setup allows for intra-operative imaging, providing timely information to clinicians during surgical and interventional procedures. IMRIS primarily serves hospitals that offer clinical services in the neurosurgical, interventional neurovascular, spinal, and cardiovascular fields. The company operates globally, with a presence in North America, Europe, the Middle East, and the Asia-Pacific region, focusing on improving visualization and the overall therapy delivery process.

Foundation Medicine, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in providing molecular information products for cancer diagnosis and treatment. The company utilizes advanced genomic profiling technologies to analyze tumor specimens, enabling healthcare providers to gain insights into individual patients' cancer profiles. This information assists in optimizing treatment strategies, particularly for targeted therapies and immunotherapies. Foundation Medicine’s product offerings include FoundationOne for solid tumors, FoundationOne Heme for blood-based cancers, and various diagnostic assays to support clinical decision-making in oncology. The company also maintains a knowledgebase, FoundationCORE, to disseminate scientific advancements and strengthen collaborations within the oncology community. Foundation Medicine has established strategic partnerships with major pharmaceutical companies and research organizations to enhance precision medicine initiatives and develop companion diagnostics for specific therapies. Founded in 2009, Foundation Medicine operates as a subsidiary of Roche Holdings, Inc.

Mako Surgical is a medical device company based in Florida, specializing in advanced robotic arm solutions and orthopedic implants for minimally invasive procedures, particularly in knee and hip surgeries. The company’s flagship offering, MAKOplasty, is a restorative surgical solution designed to assist orthopedic surgeons in treating early to mid-stage osteoarthritic conditions in patients. Mako Surgical's robotic arm interactive orthopedic system (RIO) features a tactile robotic arm and an integrated bone cutting instrument, providing pre-operative and intra-operative guidance to enhance surgical precision. This technology facilitates tissue-sparing bone removal and accurate implant insertion and alignment, ultimately improving patient outcomes. Founded in 2004, Mako Surgical has gained recognition in the medical technology field, having been named the fastest growing technology company by Deloitte and receiving multiple awards for customer excellence and innovation.

iCAD, Inc., established in 1984 and headquartered in Nashua, New Hampshire, specializes in cancer detection and therapy solutions. It offers a range of software tools for digital breast tomosynthesis and breast density analysis, along with AI-driven algorithms for detecting malignant soft-tissue densities and calcifications in mammography images. The company also provides radiation therapy systems, such as the Xoft Axxent electronic brachytherapy system, used to treat early-stage cancers. iCAD serves healthcare centers worldwide through direct sales and partnerships with OEMs, distributors, and resellers.

Tesaro, Inc. is an oncology-focused biopharmaceutical company established in 2010 and headquartered in Waltham, Massachusetts. The company is dedicated to developing and commercializing cancer therapeutics and supportive care products. Its primary offerings include ZEJULA, a potent oral poly polymerase inhibitor for the maintenance treatment of recurrent ovarian, fallopian tube, or primary peritoneal cancer, and VARUBI, a neurokinin-1 receptor antagonist designed to prevent chemotherapy-induced nausea and vomiting. Additionally, Tesaro is engaged in the development of several immunotherapy antibody candidates, including TSR-042, TSR-022, and TSR-033, all currently in phase I clinical trials. The company collaborates with various organizations, such as AnaptysBio, Janssen Biotech, and Merck Sharp & Dohme, to enhance its research and development efforts. Tesaro aims to leverage its management team's expertise to identify and commercialize innovative treatments that improve the lives of cancer patients. As of January 2019, Tesaro operates as a subsidiary of GlaxoSmithKline.

CardioMEMS is a medical device company focused on the development and commercialization of proprietary wireless sensing and communication technology aimed at enhancing the management of severe chronic cardiovascular diseases, including heart failure, hypertension, and aneurysms. The company's innovative platform features miniature wireless sensors that can be implanted using minimally invasive techniques. These sensors transmit vital data, such as cardiac output, blood pressure, and heart rate, which are essential for effective patient management. By providing continuous monitoring, CardioMEMS' technology aims to improve patient outcomes and facilitate timely medical interventions.

CardioMEMS is a medical device company focused on the development and commercialization of proprietary wireless sensing and communication technology aimed at enhancing the management of severe chronic cardiovascular diseases, including heart failure, hypertension, and aneurysms. The company's innovative platform features miniature wireless sensors that can be implanted using minimally invasive techniques. These sensors transmit vital data, such as cardiac output, blood pressure, and heart rate, which are essential for effective patient management. By providing continuous monitoring, CardioMEMS' technology aims to improve patient outcomes and facilitate timely medical interventions.

Insulet Corporation, established in 2000, specializes in the development, manufacturing, and sale of insulin delivery systems for individuals with insulin-dependent diabetes. Its flagship product, the Omnipod System, comprises a self-adhesive, disposable, and tubeless device worn on the body for up to three days, along with a wireless, handheld personal diabetes manager. The company primarily sells its products through independent distributors, pharmacies, and directly to patients, with a presence in the United States, Canada, Europe, and the Middle East. Insulet's mission is to enhance the lives of people with diabetes by providing a user-friendly, pain-free, and automated insulin delivery solution.

ISTA Pharmaceuticals is a commercial-stage pharmaceutical company based in Irvine, California, focused on developing and marketing treatments for various eye diseases and conditions. Founded in 1992, the company specializes in remedies for ocular inflammation, glaucoma, dry eye, and allergies. Its marketed products include BROMDAY, an ophthalmic solution for postoperative inflammation and pain, BEPREVE for allergic conjunctivitis, ISTALOL for glaucoma, and VITRASE, used as a spreading agent in ocular treatments. ISTA is also engaged in developing several products, including over-the-counter artificial tears, PROLENSA for postoperative pain relief, and various nasal sprays for allergic rhinitis. The company sells its products to a broad range of customers, including drug wholesalers, retail pharmacies, hospitals, and managed healthcare providers. As of June 2012, ISTA Pharmaceuticals operates as a subsidiary of Bausch & Lomb Incorporated.

NxStage Medical, Inc., established in 1998 and headquartered in Lawrence, Massachusetts, specializes in the development, manufacturing, and marketing of medical technologies for treating end-stage renal disease (ESRD) and acute kidney failure. The company's primary product is the System One, a portable hemodialysis system designed for home use. Additionally, NxStage offers water purification systems, chronic cartridges for flexible renal replacement therapy, and a telehealth platform called Nx2me Connected Health. The company also provides a range of disposable products such as bloodlines, needles, and dialysis fluids, along with dialysis services and operates dialysis centers. Since February 2019, NxStage has been a subsidiary of Fresenius Medical Care Holdings, Inc.

Third Wave Technologies, Inc. specializes in the development and marketing of molecular diagnostic products aimed at DNA and RNA analysis applications. The company provides innovative solutions for physicians and researchers focused on disease analysis and treatment. Its proprietary Invader chemistry is utilized across various segments, including women's health, infectious diseases, genetics, pharmacogenetics, and oncology. Third Wave primarily offers in vitro diagnostic devices and analyte specific reagents, which enable laboratories to create customized assays for hepatitis C virus genotyping, inherited disorders, and other genetic mutations. Additionally, the company develops products for research and agricultural biotechnology markets. Its clientele includes clinical laboratories, pharmaceutical and biotechnology firms, academic institutions, and healthcare providers. Third Wave distributes its products through a combination of direct sales personnel and collaborative partnerships in the United States and Europe. Founded in 1993 and based in Madison, Wisconsin, Third Wave Technologies operates as a subsidiary of Hologic, Inc. as of 2008.

Novare Surgical Systems, Inc. develops, manufactures, and markets devices for minimally invasive surgery. It offers motion hand-held laparoscopic instruments, which includes graspers, dissectors, cautery, and needle holders. The company's products are used in acid reflux treatment, adrenal gland removal, colon resection, gastric bypass, hysterectomy, lung lobe removal, ovary removal, prostate removal, achalasia treatment, appendix removal, gall bladder removal, hernia repair, lymph node extraction, kidney removal, pelvic mass removal, and spleen removal procedures. It provides its products through its sales representatives in the United States, Austria, Belgium, Canada, Denmark, Greece, Israel, Italy, Korea, Sweden, Switzerland, and Turkey. Novare Surgical Systems, Inc. was founded in 1999 and is headquartered in Cupertino, California.

Breathe Technologies, Inc. is a medical technology company based in Irvine, California, that specializes in developing and manufacturing innovative respiratory therapies for treating respiratory insufficiency diseases. Founded in 2005, the company focuses on creating non-invasive open ventilation systems aimed at helping patients with conditions such as interstitial lung diseases, neuromuscular disorders, and those undergoing lung transplants. Their lightweight, volume-control mechanical ventilators are designed to enhance patient mobility and are suitable for use in various healthcare settings, including general medical units, intensive care, and pulmonary rehabilitation. As a subsidiary of Hill-Rom, Breathe Technologies is committed to providing reliable and accessible solutions that optimize breathing and improve the quality of life for patients both in hospital and home environments.