Delphi Ventures

Arrow Markets operates a decentralized financial market options protocol designed to democratize returns for option market makers. By eliminating intermediaries such as brokers and clearinghouses, the platform streamlines the entire options trading process, facilitating market making, brokering, and settlement directly on its protocol. This approach allows liquidity providers to engage in hedging activities similar to those of traditional market makers while benefiting from reduced costs. The protocol employs cash settlement for all contingent claims, enhancing efficiency and accessibility in options trading.

MyShell is a decentralized and comprehensive platform for discovering, creating, and staking AI-native apps.

Builders of Citrea, Bitcoin's First ZK Rollup. The last few decades of innovation were defined by the internet. We believe Bitcoin and blockchains will shape the coming decades. We are a blockchain infrastructure company focused on Bitcoin, Ethereum, and Zero Knowledge technology.

Nous Research develops human-centric language models and simulators, focusing on AI flexibility and adaptability.

HYTOPIA is a metaverse platform that integrates social functions and offers developers a Minecraft-inspired game creation toolkit with flexible monetization.

FastLane is a developer of a platform aimed at enhancing network efficiency and user experience in the blockchain space. The protocol focuses on generating revenue for validators while optimizing the performance of algorithmic traders. It employs ecosystem-friendly MEV relays to minimize transaction spam and bolster network health. This approach not only safeguards user interactions but also boosts the yield of liquid staking derivatives, improving the chances of success for beneficial trading bots. By simplifying the integration of sentry nodes through a single command line, FastLane aims to streamline operations for users and contribute to a more effective and sustainable blockchain environment.

Karate Combat is a professional organization focused on revitalizing the martial art of karate through a dynamic combat sports league. It organizes full-contact events held in various exotic locations worldwide, allowing fighters to compete under rules designed to promote continuous action. The organization aims to deliver high-quality, engaging fights akin to Hollywood productions, enhancing the viewer experience. In addition to hosting tournaments and events, Karate Combat also provides training opportunities and sells tickets for its competitions. For inquiries, the organization offers contact via phone and email.

Mirage is focused on developing an augmented reality infrastructure and artist tooling platform aimed at enhancing digital art and media services. The company creates tools that enable digital artists to easily create, distribute, and store augmented reality content. This platform facilitates the engagement of creators and audiences, allowing them to build and curate a decentralized trans-digital reality that seamlessly connects the physical and digital realms. Through its innovative approach, Mirage aims to empower artists and enhance the overall experience of digital art.

Skylock is a Canadian post-seed startup committed to securing the future of DeFi by proactively defending against smart-contract hacks. Recognizing the industry's need for stability, Skylock leverages cutting-edge technology to detect and block malicious transactions in real-time, protecting DeFi protocols and their users. Skylock was founded in 2022 in Ottawa, Canada.

Godmode is the AI-native sales enablement tools. Helps you connect and build with genuine human relationships and proactively finds you leads based on your ideal customer profile and signals on the web.

Suberra is a company that specializes in facilitating cryptocurrency payments for businesses, aiming to enhance the user experience in this evolving financial landscape. It offers a range of services, including the acceptance of crypto payments for commerce, one-time transactions, and subscription models. Suberra's payment infrastructure is designed to enable safe and secure transactions, providing both consumers and merchants with a streamlined process for using cryptocurrencies and stablecoins. This approach not only simplifies payment acceptance for businesses but also empowers consumers to transact more freely and efficiently in their everyday purchases.

Jito Labs is a blockchain infrastructure company focused on maximizing rewards for validators on the Solana network while mitigating the negative impacts associated with miner extractable value (MEV). The company develops an open-source validator client and a block engine designed to create efficient and profitable blocks, enhancing the trading capabilities of validators. By providing these tools, Jito Labs enables users to optimize their revenue streams and make better use of their hardware resources.

AMGI Studios is an animation technology agency that focuses on integrating animation with gaming. The company develops and produces both traditional entertainment and Web3 native properties, utilizing proprietary technology and innovations in real-time animation. By offering services in animation, art direction, and puppeteering, AMGI supports existing studio pipelines and enhances the landscape of animated content. Their approach merges artistry with technology, allowing animators to create compelling animated art efficiently.

Tatsumeeko is a Discord-first fantasy massively multiplayer online role-playing game (MMORPG).

ZGEN is a software firm that builds smart contracts on web3 applications for DeFi and DAO communities. They also involve in tobBuilding essentials for internet communities.

Voyage Finance is a company that specializes in providing decentralized loans tailored for gamers and gaming guilds within the Web3 ecosystem. Its platform is designed to facilitate financial support for users by offering in-game services and enabling the purchase of yield-generating assets. Additionally, it features a "play and repay" mechanism that allows gamers to manage their loans conveniently while engaging in their gaming activities. This approach aims to enhance the financial capabilities of gamers and guilds, making it easier for them to participate in the growing landscape of online gaming.

Pollen Mobile operates a decentralized mobile network that is owned and managed by its users, leveraging blockchain technology to enhance mobile connectivity. The network utilizes citizens broadband radio service (CBRS) and incorporates a crypto-economy centered around Pollen Coin, Magma, and various open-source protocols. By offering a user-owned and operated alternative, Pollen Mobile aims to provide reliable, affordable, and privacy-focused mobile services, distinguishing itself from traditional mobile carriers.

Polemos is a global Gaming company that has developed advanced proprietary asset management solutions, non-collateralised lending solutions, proprietary learning management systems (LMS), advanced game/player data analytics solutions, and range of gaming focussed media and entertainment assets. Polemos was ideated and launched in early 2020 by five international cofounders that have investment and business interests in strategically aligned industry sectors. Commonly confused as a 'blockchain' business, Polemos delivers solutions to all traditional and emerging strategy gaming verticals. Led by renown global technology executive Richard McLaren, most well known for his roles as Managing Director of Microsoft NineMSN (APAC), Head of MoneySupermarket.com, Global Director at McKinsey and BCG, and as Managing Director of ThoughtWorks, and Hal Crawford - former Chief Editor and Publisher at Microsoft NineMSN, and Global CEO at Mediaworks, the business is expanding rapidly into a large number of globally distributed markets - not dissimilar to those markets pursued by Microsoft for its content business originally. Cofounders of Polemos include: Tom Hall - Former CEO of Playtech and Asian Logic, CEO of Sporting News (https://www.linkedin.com/in/tomhallhk/) - Tom Hall is recognised as a pioneer and one of the world’s leading experts in the field of online gaming software development, specialising in interactive gaming and is a regular key note speaker at investor forums and gaming conferences around the World. Tom is known globally for his role as Co-Founder and CEO of Asianlogic, an Asian-facing gaming group established in 2002. He also led Playtech as Group CEO and oversaw the successful floatation of the Company on the UK AIM market in 2006. Playtech was the world’s largest publicly quoted gaming software provider (UK:PTEC - USD3.5Bn+ Market Cap). Of Eurasian Hong Kong origin, Tom was responsible for overseeing global customer growth and the development of customised software solutions for the Asia Pacific marketplace. He retired in 2020 as Chairman to pursue his interests in the media sector. Previously publicly listed in the UK, ALOG was taken private in 2009 and grew to become one of the Top 10 Global online gaming companies with 2500 staff across 6 countries. Since 2014, Hall has spent most of his time building Pax Holdings Limited, a family office focussed on sports media, fintech, gaming, leisure-related real estate and asset management platform software development. As at 2020, his core focus is Pax’s digital media expansion, most recently leading the acquisition of The Sporting News, www.sportingnews.com, the digital evolution of the US's oldest sports newspaper founded in 1886. He has also recently joined the Board of Leisurerights.com, a newly formed rights management collective. Zac Rosenberg - Managing Partner at Capzed (https://www.linkedin.com/in/zac-rosenberg-079a34/) - Zac co-founded Capital Zed in January 2015. Previously was Managing Director/Head of Investment Banking from 2012 to 2015 at Canaccord Genuity (Melbourne), Managing Director/Head of Investment Banking from 2009 to 2012 at Keefe, Bruyette & Woods (Hong Kong), Managing Director/ Head of Investment Banking at Fox-Pitt, Kelton (Hong Kong) from 2005 to 2009 and Executive Director at CIBC World Markets (Hong Kong/Singapore) from 2000 to 2005 His current Board roles include Mobi2Go (New Zealand), The Influential Network (USA), Predictive Hire (Australia), Fresho (Australia), Campaign Agent (Australia), as well as several private investment companies and vehicles. Zac holds a Bachelor of Commerce from Monash University. Darren Smorgon - Managing Director of Sandbar Investments (https://www.linkedin.com/in/darren-smorgon-20214713/) - Darren is Managing Director of Sandbar Investments, a Sydney based family office with investments in private equity, equities, property and alternative investments including venture capital and crypto currency. Until 2015, Darren was a Director, member of the advisory board and partner at CHAMP Private Equity where he was responsible for portfolio companies including oOh!media, Study Group, Golding Contractors and LCR Group. Darren is currently Chairman of Hub Australia, Non Executive Director of Total Drains Group and Swift Networks, Co-Founder and Non Executive Director of Arrowpoint Capital. He is also actively involved in several philanthropic activities including as a member of the Allocations Committee of the JCA and the Chairman of Nextthink. Kevin O’Hara - Managing Director of Sentor Investments and Partner at Trivian Capital Management (https://www.linkedin.com/in/kevino23/) - Kevin has an extensive history as an investor and founder. In 2005 Kevin founded OCTIEF Group (Acquired by IHG and Tulla Private Equity) and in 2010 Kevin founded the OCTFOLIO SaaS based Enterprise Governance, Risk and Compliance Management (eGRCM) Solution (acquired by HRL and ALS Global Limited). Kevin has an MBA with a major in Digital Transformation and Business Intelligence and is currently Managing Director of Sentor Investments, Venture Partner at SDGx Climate Technology Fund, Venture Partner and IC Member at Primal Capital and IC Member at Newzone Ventures in Portugal. Scott Plowman - Managing Director of Mozaik Capital (https://www.linkedin.com/in/scottplowman/) - Scott is the Managing Director of Mozaik Capital based in Singapore, Co-Founder of Polemos.io, acting DAO Key Controller for the Polemos DAO, and Foundation Partner and Investor in Herradura Ventures. Mozaik Capital is most well known as one of the original Venture focussed Web3 investors, with multiple exits across Axie Infinity, Algorand, DFinity, STEPN, Yield Guild and Kava to name a few. In the web3 investing space, Scott is known for the establishment and management of large scale project validator and node structures, including for the Algorand protocol in 2018.. Today Scott is also actively involved at the foundation level of numerous technology companies. Scott’s background is in the establishment, administration and portfolio management for numerous large-scale funds and financial services organisations, and in high level technical/quantitative market analysis and derivatives trading.

Crypto Raiders is a highly-interactive dungeon crawler game built on the blockchain. Players have the ability to buy characters and mobs, go on missions, build teams in a virtual universe all while discovering NFTs they then own. Crypto Raiders is built on the Polygon blockchain, and all NFT loot is randomized, ensuring that the value of all discovered loot is random as well.

Crypto Unicorns is a Web3 game development and research and development studio.

MetalCore is a maker of computer games. They provide services for fighting games. They provide products that include mechs, infantry, aircraft, and vehicles.

Squads is a developer of a decentralized program that enables the establishment of better and easier decentralized autonomous groups. The company's application combines all of the key components of a decentralized autonomous organization, such as deployment, treasury, vault management, on-chain voting, and chat, into a single portal with an easy-to-use interface, allowing users to streamline daily operations using a decentralized autonomous organization structure.

Jambo is a company focused on creating an extensive on-chain mobile network, centered around its flagship product, the JamboPhone, a powerful mobile device designed for the crypto-native market. With a foundation of over 800,000 mobile nodes spanning more than 120 countries, Jambo aims to accelerate decentralization and enhance network effects for various applications, such as validators and peer-to-peer networking. The JamboApp serves as a gateway for millions of users to engage with the on-chain economy, offering innovative earning opportunities, a decentralized application (dApp) store, and a multi-chain wallet. By integrating blockchain technology into its products, Jambo empowers users to participate in gaming, cryptocurrency trading, and decentralized finance, particularly benefiting individuals in emerging markets. Central to Jambo's ecosystem is the Jambo Token, which facilitates rewards, discounts, and other incentives, positioning the company as a key player in the evolving landscape of blockchain technology.

EnterDAO is a decentralized autonomous organization focused on developing products that facilitate new markets within the Web3 metaverse economy. It offers a cross-platform web3-enabled desktop application that serves as a centralized access point for various metaverse games. This application allows users to efficiently manage and interact with virtual land while providing seamless onboarding into different metaverse experiences. EnterDAO aims to enhance user engagement and streamline interactions within the evolving landscape of the metaverse.

DOOMSDAYX is a creative technology studio dedicated to supporting web3 artists and their fans, with an emphasis on transforming culture through on-chain innovations. The studio specializes in educating artists about non-fungible tokens (NFTs) and the broader web3 ecosystem. By offering a range of services, DOOMSDAYX empowers artists to connect with the native crypto community and reach a wider retail audience. Additionally, the company fosters deeper engagement between fans and their favorite artists, enhancing the overall experience within the web3 landscape.

Hubble Protocol is a decentralized financial platform that facilitates long-term borrowing, lending, and the creation of structured financial products. It aims to democratize access to decentralized finance by offering a range of sustainable financial services. The protocol's software supports multi-asset collateral and enables zero-interest borrowing, allowing users to leverage yield-bearing assets for loans. Additionally, Hubble enhances yield generation on deposits of various tokens, providing clients with optimized financial opportunities while minimizing costs associated with loans.

Friktion Labs is a developer of a decentralized finance (DeFi) portfolio management platform focused on sustainable and intelligent investing. The organization comprises a team of quantitative traders, researchers, and crypto engineers with expertise in commodities, treasuries, volatility products, and crypto-assets. Friktion offers an automated portfolio manager (APM) that allows investors to input their existing portfolio information, including spot trading, perpetual, and liquidity positions. This tool helps users optimize their investment strategies by generating profits across various market cycles and enabling them to monitor profit fluctuations in different markets. The team includes experienced professionals from notable trading firms, enhancing its capabilities in the competitive DeFi landscape.

Suberra is a company that specializes in facilitating cryptocurrency payments for businesses, aiming to enhance the user experience in this evolving financial landscape. It offers a range of services, including the acceptance of crypto payments for commerce, one-time transactions, and subscription models. Suberra's payment infrastructure is designed to enable safe and secure transactions, providing both consumers and merchants with a streamlined process for using cryptocurrencies and stablecoins. This approach not only simplifies payment acceptance for businesses but also empowers consumers to transact more freely and efficiently in their everyday purchases.

Hubble Protocol is a decentralized financial platform that facilitates long-term borrowing, lending, and the creation of structured financial products. It aims to democratize access to decentralized finance by offering a range of sustainable financial services. The protocol's software supports multi-asset collateral and enables zero-interest borrowing, allowing users to leverage yield-bearing assets for loans. Additionally, Hubble enhances yield generation on deposits of various tokens, providing clients with optimized financial opportunities while minimizing costs associated with loans.

Beta Finance is a decentralized finance protocol that facilitates lending, borrowing, and short-selling of cryptocurrency assets. Designed as a permissionless money market, it seeks to mitigate the inherent volatility of the crypto market and enhance overall market stability. The platform provides a user-friendly, one-click solution, allowing traders without technical expertise to easily manage and update their short positions. It presents all relevant token information directly on the interface, empowering users to make informed decisions in the dynamic crypto landscape.

LayerZero Labs is a developer of a blockchain messaging protocol that enables decentralized applications to function across multiple blockchains. The company's platform focuses on interoperability, facilitating data exchange between disparate blockchains. Unlike traditional methods that require sequential storage of all block headers, LayerZero employs an on-chain light node for validation, allowing block headers to be streamed on-demand by decentralized oracles. This innovative approach enhances speed, security, and cost-efficiency, providing clients with a low-level communication primitive necessary for cross-chain applications.

Tessera's mission is to curate the most extraordinary collective ownership experiences produced by the greatest creators, builders, and leaders. Tessera's vision is a world where anyone can have the opportunity to collectively own and govern things they value, without reliance on central gatekeepers to execute decisions and actions on their behalf.

Pontem Network is a product studio focused on developing foundational decentralized applications (dApps) for the Aptos blockchain. Its flagship product, the Pontem Wallet, is a secure wallet available on multiple platforms, including Chrome, Firefox, iOS, and Android, allowing users to store and send tokens on the Aptos network. The wallet is integrated with various services, including the Liquidswap decentralized exchange, NFT marketplaces like Topaz and Souffl3, and liquid staking platforms such as Ditto and Tortuga. Additionally, Pontem Network offers tools for developers, including the Move Playground browser code editor, the Move IntelliJ IDE plugin, and ByteBabel, a Solidity-to-Move code translator that enables Ethereum Virtual Machine compatibility on Aptos. Through these products, Pontem Network aims to facilitate innovation and support the growth of the Aptos ecosystem.

Bright Star Studios is an independent game development company located in Swatar, Malta, specializing in the creation of multiplayer online video games. The studio focuses on developing original MMO game franchises using its proprietary engine and aims to innovate the MMORPG landscape across platforms, including PC, mobile, and browsers. Its flagship title, Ember Sword, represents a modern approach to gaming, emphasizing a player-owned economy and community engagement. By promoting competitive gameplay and instant playability, Bright Star Studios seeks to foster a gaming environment that prioritizes skill and user involvement, challenging traditional business models in the industry.

Fractal is a financial technology company that provides digital assets and blockchain adoption services. They also develop tools for institutional investors to access decentralized financing.

Fully permissionless protocol for decentralized perpetual swaps

XDEFI Wallet is a non-custodial cryptocurrency wallet that enables users to securely store, send, and swap digital assets, including NFTs, across 30 different blockchains. The wallet is designed to facilitate interaction with various decentralized finance (DeFi) protocols, making it a vital tool for users looking to engage in the growing DeFi ecosystem. With over 200,000 users, XDEFI Wallet provides a user-friendly platform that allows seamless access to decentralized marketplaces and NFT applications directly through web browsers. Its chain-agnostic capabilities and robust features position XDEFI Wallet as an essential resource for individuals participating in the evolving landscape of digital finance and asset management.

Covalent is the leading modular data infrastructure layer dedicated to solving major challenges in blockchain and AI, including verifiability, decentralized AI inference, and Long-Term Data Availability. Its large reservoir of structured, verifiable data enhances decentralized training and inference, reducing the risk of manipulated or biased AI models. Additionally, the Covalent Network's Ethereum Wayback Machine ensures secure, decentralized access to Ethereum’s transaction data. Trusted by over 3,000 leading organizations, Covalent powers AI, DeFi, GameFi, and more with unfettered access to on-chain data from over 225 blockchains. Learn about the EWM: Technical | Non-Technical For more information, check out Covalent’s: Official Website | Twitter/X | Linktree

Anchor Protocol is a savings platform that provides crypto natives, fintech companies, and investors a stable, high interest rate finance. The company was founded in 2020 and is headquartered in Seoul, South Korea.

Armor develops a dynamic cover brokerage protocol for decentralized finance to serve cryptocurrency investors. Founded in 2021, Armor is a DeFi coverage aggregator that makes securing your DeFi assets against hacks as easy as possible. Ease wants to make DeFi as easy and safe as possible. They aim to cover every dollar in DeFi so that users can finally feel at ease.

Caravan Wellness specializes in corporate wellness programs and online education solutions aimed at promoting healthier lifestyles. The company offers a variety of wellness lessons, training classes, and challenges led by experts, focusing on nutrition, fitness, mindfulness, and productivity. By utilizing science-based methods and impact tracking, Caravan Wellness helps individuals and organizations cultivate better habits and enhance overall performance. Through brand partnerships and collaborations with influencers, the company aims to deliver exclusive digital content that supports employee wellness and fosters a culture of health within organizations.

LeddarTech Inc. is a Canadian company that specializes in developing advanced detection and ranging systems, utilizing time-of-flight measurement technology with infrared LEDs. Its product offerings include smart sensor modules for various applications, such as single-element and multi-element sensor modules, LED-based traffic management sensors, and sensor evaluation kits. These solutions are designed for a wide range of applications, including advanced driver assistance systems (ADAS), autonomous driving, public safety, and industrial monitoring. LeddarTech's flagship platform, LeddarVision™, integrates multiple sensor types to create comprehensive 3D environmental models, facilitating improved perception and navigation capabilities in vehicles. The company aims to address critical sensing challenges for OEMs and automotive suppliers, helping them enhance performance while reducing development time and costs. Founded in 2007 and headquartered in Quebec City, Canada, LeddarTech maintains a research and development office in Toronto and has secured numerous patents in the field of remote sensing technologies.

AEGEA Medical, Inc. is a medical technology company based in Menlo Park, California, focused on improving women's healthcare through innovative treatment options. The company has developed a water vapor ablation system, known as Mara, which provides a safe and effective method for endometrial ablation to treat heavy menstrual bleeding, or menorrhagia. This FDA-approved technology allows for a straightforward, office-based procedure that typically takes only minutes to perform. AEGEA is dedicated to enhancing patient outcomes and expanding access to effective therapies, while also supporting physicians in delivering these procedures with confidence and ease. Founded in 2008, AEGEA Medical is committed to pioneering advancements in women’s health.

AEGEA Medical, Inc. is a medical technology company based in Menlo Park, California, focused on improving women's healthcare through innovative treatment options. The company has developed a water vapor ablation system, known as Mara, which provides a safe and effective method for endometrial ablation to treat heavy menstrual bleeding, or menorrhagia. This FDA-approved technology allows for a straightforward, office-based procedure that typically takes only minutes to perform. AEGEA is dedicated to enhancing patient outcomes and expanding access to effective therapies, while also supporting physicians in delivering these procedures with confidence and ease. Founded in 2008, AEGEA Medical is committed to pioneering advancements in women’s health.

Cardeas Pharma is focused on developing a novel antibiotic formulation that combines two drugs to effectively target highly resistant Gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, as well as carbapenem-resistant Enterobacteriaceae. This formulation is also effective against biofilms and Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The antibiotics are delivered through a single-patient use nebulizer that produces small, uniform aerosol droplets, allowing for targeted delivery to the small airways and alveoli. By integrating this innovative antibiotic formulation with advanced drug-delivery technology, Cardeas Pharma aims to improve clinical outcomes for patients suffering from serious, hospital-acquired respiratory infections.

EBR Systems, Inc. is focused on developing innovative implantable devices for cardiac rhythm management, specifically aimed at treating patients with heart failure and cardiac arrhythmias. The company's flagship product, the Wireless Cardiac Stimulation of the Left Ventricle System, utilizes proprietary wireless technology to provide endocardial pacing for cardiac resynchronization therapy. This approach enhances the heart's pumping efficiency by synchronizing the contractions of the left and right ventricles. Founded in 2003 and headquartered in Sunnyvale, California, EBR Systems is committed to advancing therapeutic options for patients suffering from cardiac rhythm diseases through its novel technologies.

EBR Systems, Inc. is focused on developing innovative implantable devices for cardiac rhythm management, specifically aimed at treating patients with heart failure and cardiac arrhythmias. The company's flagship product, the Wireless Cardiac Stimulation of the Left Ventricle System, utilizes proprietary wireless technology to provide endocardial pacing for cardiac resynchronization therapy. This approach enhances the heart's pumping efficiency by synchronizing the contractions of the left and right ventricles. Founded in 2003 and headquartered in Sunnyvale, California, EBR Systems is committed to advancing therapeutic options for patients suffering from cardiac rhythm diseases through its novel technologies.

Senseonics Holdings, Inc. is a medical technology company based in Germantown, Maryland, specializing in the development and commercialization of continuous glucose monitoring (CGM) systems for individuals with diabetes. Founded in 1996, the company focuses on innovative and long-term implantable glucose monitoring solutions that utilize advanced fluorescence sensing technology. Its flagship products, Eversense and Eversense XL, are implantable CGM systems designed to monitor glucose levels for up to 90 and 180 days, respectively. These products aim to provide users with a reliable and stable means of glucose management, enhancing their ability to live confidently and manage their diabetes effectively. The majority of Senseonics' revenue comes from international markets, reflecting its strong presence in Europe.

Sotera Wireless, Inc. is a medical device company dedicated to the development, marketing and sale of a new generation of comprehensive vital signs monitoring. Sotera’s mission is to improve patient safety by empowering clinicians to detect early signs of deterioration in virtually any care setting and enable early intervention and rapid response, all without limiting the patient’s freedom of movement.

ForSight VISION5, founded in 2010 as part of ForSight Labs, specializes in developing innovative drug delivery technologies aimed at treating various eye conditions. The company focuses on creating non-invasive products designed to replace traditional eye drops, offering sustained therapy for significant eye diseases such as glaucoma, dry eye, and allergies. Currently, ForSight VISION5 is in its second Phase 2 clinical study for its lead product, the Helios insert, which represents a significant advancement in ocular treatment options.

Sequent Medical, Inc. is a medical device company focused on developing catheter-based neurovascular technologies. Founded in 2007 and headquartered in Aliso Viejo, California, with operations in Bonn, Germany, the company has created the proprietary Microbraid technology, which is integral to its WEB Aneurysm Embolization System. This system provides a versatile option for treating both ruptured and unruptured intracranial aneurysms and has received CE mark approval. The WEB device has been successfully used to treat nearly 600 aneurysms across Europe, Latin America, and New Zealand, although it is not available for sale or use in the United States. Sequent Medical, Inc. operates as a subsidiary of MicroVention, Inc.

Ivantis Inc. is a medical device company based in Irvine, California, focused on developing innovative treatments for primary open-angle glaucoma. Founded in 2007, the company specializes in a minimally invasive intracanalicular scaffold that alleviates high intraocular pressure by restoring the natural outflow pathway in Schlemm's canal. This device aims to provide a less invasive and more effective solution for the over 60 million individuals worldwide affected by this condition. In addition to its primary focus on glaucoma, Ivantis intends to explore innovative treatments for other ophthalmic diseases as it expands its product offerings. The company also provides a Session Persistence Server to support clinical trials, ensuring data protection for telnet task workers and terminal emulation users across various devices and operating systems.

TriVascular Technologies, Inc. is a medical device company focused on developing and commercializing technologies for the minimally invasive treatment of abdominal aortic aneurysms (AAA) and thoracic aortic conditions. The company is known for its Ovation System, which includes a stent graft platform designed for endovascular aortic repair. Key components of the Ovation System feature an aortic body, iliac limbs, and polymer fill, which contribute to its effectiveness in treating AAA. TriVascular markets its products through direct sales in the United States and several European countries, as well as via distributors in other regions. Founded in 2007 and headquartered in Santa Rosa, California, TriVascular has been recognized for its innovative approach to addressing unmet clinical needs in aortic disease treatment. The company operates as a subsidiary of Endologix Inc.

Calithera Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule drugs targeting tumor metabolism and immunology for cancer treatment. The company's lead candidate, CB-839, is a glutaminase inhibitor currently in Phase II clinical trials aimed at treating solid tumors. Additionally, Calithera is advancing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology. Other notable projects include CB-280, intended for cystic fibrosis treatment, and CB-708, an inhibitor of CD73. The company has established collaborations, including a license agreement with Mars, Inc. for the development of arginase inhibitors and a clinical trial partnership with Bristol-Myers Squibb to evaluate nivolumab in combination with CB-839. Founded in 2010, Calithera is focused on building a pipeline of innovative cancer therapeutics that address critical pathways necessary for tumor growth and survival.

Karyopharm Therapeutics Inc. is a clinical-stage biopharmaceutical company based in Newton, Massachusetts, specializing in the discovery, development, and commercialization of novel drugs targeting nuclear export mechanisms for the treatment of cancer and other diseases. Its lead drug, XPOVIO (selinexor), is an approved treatment for multiple hematologic malignancies, particularly in patients with heavily pretreated multiple myeloma. The company is advancing several clinical trials for its products, including BOSTON and STORM for multiple myeloma, SADAL for relapsed or refractory diffuse large B-cell lymphoma, and SEAL for liposarcoma. Karyopharm is also exploring treatments for endometrial cancer and glioblastoma multiforme. Additionally, the company has partnerships to investigate low-dose selinexor for hospitalized COVID-19 patients and collaborates with the National Cancer Institute for cancer therapy evaluations. Karyopharm utilizes a proprietary platform to develop small molecule drugs that modulate key cellular pathways involved in cancer and inflammation.

ForSight Labs is dedicated to developing innovative ophthalmic technologies aimed at enhancing the sight and quality of life for visually impaired patients. The organization collaborates with entrepreneurs, investors, and clinicians to drive advancements in eye care through the creation and commercialization of high-impact solutions. With millions of individuals in the U.S. suffering from vision impairment and the associated economic burden exceeding $50 billion annually, ForSight Labs addresses a significant public health challenge. Their focus includes developing treatments for conditions such as glaucoma, which can lead to irreversible blindness in adults. By fostering a creative and cooperative environment, ForSight Labs strives to deliver effective solutions to the ophthalmic community and the patients it serves.

ForSight VISION5, founded in 2010 as part of ForSight Labs, specializes in developing innovative drug delivery technologies aimed at treating various eye conditions. The company focuses on creating non-invasive products designed to replace traditional eye drops, offering sustained therapy for significant eye diseases such as glaucoma, dry eye, and allergies. Currently, ForSight VISION5 is in its second Phase 2 clinical study for its lead product, the Helios insert, which represents a significant advancement in ocular treatment options.

Karyopharm Therapeutics Inc. is a clinical-stage biopharmaceutical company based in Newton, Massachusetts, specializing in the discovery, development, and commercialization of novel drugs targeting nuclear export mechanisms for the treatment of cancer and other diseases. Its lead drug, XPOVIO (selinexor), is an approved treatment for multiple hematologic malignancies, particularly in patients with heavily pretreated multiple myeloma. The company is advancing several clinical trials for its products, including BOSTON and STORM for multiple myeloma, SADAL for relapsed or refractory diffuse large B-cell lymphoma, and SEAL for liposarcoma. Karyopharm is also exploring treatments for endometrial cancer and glioblastoma multiforme. Additionally, the company has partnerships to investigate low-dose selinexor for hospitalized COVID-19 patients and collaborates with the National Cancer Institute for cancer therapy evaluations. Karyopharm utilizes a proprietary platform to develop small molecule drugs that modulate key cellular pathways involved in cancer and inflammation.

Revance Therapeutics is a biotechnology company that focuses on developing, manufacturing, and commercializing neuromodulators for aesthetic and therapeutic applications. Its primary product, DaxibotulinumtoxinA for injection (DAXI), is undergoing various clinical trials for treating conditions such as glabellar lines, cervical dystonia, adult upper limb spasticity, and plantar fasciitis, while also being explored for chronic migraine treatment. Additionally, Revance is developing topical formulations of DAXI and a biosimilar to BOTOX. The company has established collaborations for the development and commercialization of these products. Revance also offers a portfolio of aesthetic products, including the RHA Collection of dermal fillers and the HintMD platform. Founded in 1999 and headquartered in Newark, California, Revance Therapeutics was previously known as Essentia Biosystems.

PTC Therapeutics, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of orally administered small-molecule therapeutics for the treatment of rare disorders and cancer. The company offers Translarna, used for nonsense mutation Duchenne muscular dystrophy in ambulatory patients, and Emflaza, a corticosteroid for the same condition. PTC Therapeutics is advancing several candidates in clinical development, including Translarna for other rare genetic conditions, RG7916 and RO7034067 for spinal muscular atrophy, and PTC596 and PTC299, which target cancer through dihydrooratate dehydrogenase inhibition. Additionally, the company is developing a gene therapy candidate, PTC-AADC, for Aromatic L-amino acid decarboxylase deficiency. PTC Therapeutics collaborates with various organizations, including F. Hoffman-La Roche Ltd and Massachusetts General Hospital, to further its research and commercialization efforts. Founded in 1998, the company is headquartered in South Plainfield, New Jersey.

Sotera Wireless, Inc. is a medical device company dedicated to the development, marketing and sale of a new generation of comprehensive vital signs monitoring. Sotera’s mission is to improve patient safety by empowering clinicians to detect early signs of deterioration in virtually any care setting and enable early intervention and rapid response, all without limiting the patient’s freedom of movement.

Ivantis Inc. is a medical device company based in Irvine, California, focused on developing innovative treatments for primary open-angle glaucoma. Founded in 2007, the company specializes in a minimally invasive intracanalicular scaffold that alleviates high intraocular pressure by restoring the natural outflow pathway in Schlemm's canal. This device aims to provide a less invasive and more effective solution for the over 60 million individuals worldwide affected by this condition. In addition to its primary focus on glaucoma, Ivantis intends to explore innovative treatments for other ophthalmic diseases as it expands its product offerings. The company also provides a Session Persistence Server to support clinical trials, ensuring data protection for telnet task workers and terminal emulation users across various devices and operating systems.

Labcyte Inc. is a laboratory instrumentation company based in San Jose, California, specializing in acoustic droplet ejection (ADE) technology for life sciences applications. Established in 2000, Labcyte develops innovative solutions for drug discovery, genomic research, cancer research, and personalized medicine through its precise liquid dispensing technology. This technology utilizes focused acoustic energy to eject nanoliter-scale droplets of fluid, allowing for high accuracy and reduced consumption of materials. Labcyte's product offerings include automation systems, laboratory workstations, and control software aimed at enhancing research efficiency and data reliability. The company operates as a subsidiary of Beckman Coulter, Inc. and maintains additional offices across multiple countries, including Canada, the United Kingdom, and Japan.

Calithera Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule drugs targeting tumor metabolism and immunology for cancer treatment. The company's lead candidate, CB-839, is a glutaminase inhibitor currently in Phase II clinical trials aimed at treating solid tumors. Additionally, Calithera is advancing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology. Other notable projects include CB-280, intended for cystic fibrosis treatment, and CB-708, an inhibitor of CD73. The company has established collaborations, including a license agreement with Mars, Inc. for the development of arginase inhibitors and a clinical trial partnership with Bristol-Myers Squibb to evaluate nivolumab in combination with CB-839. Founded in 2010, Calithera is focused on building a pipeline of innovative cancer therapeutics that address critical pathways necessary for tumor growth and survival.

Tandem Diabetes Care, Inc. is a medical device company headquartered in San Diego, California, which specializes in the design, development, and commercialization of insulin delivery systems for individuals with insulin-dependent diabetes. Its flagship product, the t:slim X2 insulin delivery system, includes a pump, a 300-unit disposable insulin cartridge, and an infusion set. The company offers advanced features such as Basal-IQ Technology and Control-IQ Technology, along with the Tandem Device Updater for software enhancements. Additionally, Tandem provides the t:connect web-based data management application and the Sugarmate mobile app to support diabetes management for users and their caregivers. Tandem Diabetes Care entered the insulin pump market in 2012 and has since expanded its product line, including the recent launch of the smaller Mobi pump and development of a tubeless pump. The majority of the company’s revenue is generated in the United States, with additional sales from other developed countries.

Relypsa, Inc. is a biopharmaceutical company based in Redwood City, California, specializing in the development and commercialization of late-stage medicines for conditions primarily in the iron deficiency, nephrology, and cardio-renal therapeutic areas. The company is known for its product VELTASSA, a potassium binder designed to treat hyperkalemia. Relypsa focuses on discovering and developing non-absorbed polymeric drugs that address cardiovascular and renal diseases, particularly conditions that are often overlooked or undertreated. Established in 2007, Relypsa operates as a subsidiary of Vifor Pharma Ltd.

PTC Therapeutics, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of orally administered small-molecule therapeutics for the treatment of rare disorders and cancer. The company offers Translarna, used for nonsense mutation Duchenne muscular dystrophy in ambulatory patients, and Emflaza, a corticosteroid for the same condition. PTC Therapeutics is advancing several candidates in clinical development, including Translarna for other rare genetic conditions, RG7916 and RO7034067 for spinal muscular atrophy, and PTC596 and PTC299, which target cancer through dihydrooratate dehydrogenase inhibition. Additionally, the company is developing a gene therapy candidate, PTC-AADC, for Aromatic L-amino acid decarboxylase deficiency. PTC Therapeutics collaborates with various organizations, including F. Hoffman-La Roche Ltd and Massachusetts General Hospital, to further its research and commercialization efforts. Founded in 1998, the company is headquartered in South Plainfield, New Jersey.

Relypsa, Inc. is a biopharmaceutical company based in Redwood City, California, specializing in the development and commercialization of late-stage medicines for conditions primarily in the iron deficiency, nephrology, and cardio-renal therapeutic areas. The company is known for its product VELTASSA, a potassium binder designed to treat hyperkalemia. Relypsa focuses on discovering and developing non-absorbed polymeric drugs that address cardiovascular and renal diseases, particularly conditions that are often overlooked or undertreated. Established in 2007, Relypsa operates as a subsidiary of Vifor Pharma Ltd.

Astute Medical, Inc. is a life science tools company specializing in the discovery and development of protein biomarkers for rapid diagnosis and risk assessment of acute medical conditions. Founded in 2007 and based in San Diego, California, with a location in Paris, France, the company focuses on validating prognostic biomarkers related to conditions such as abdominal pain, acute coronary syndromes, cerebrovascular injury, kidney injury, and sepsis. Its primary product, NephroCheck, is a single-use cartridge designed to detect biomarkers of acute kidney injury, while the Astute140 meter converts the fluorescent signals from the NephroCheck cartridge into a single numerical result. Astute Medical's products are marketed in the United States and Europe and aim to enhance clinical decision-making and patient outcomes. As of April 2018, Astute Medical operates as a subsidiary of bioMérieux S.A.

TriVascular Technologies, Inc. is a medical device company focused on developing and commercializing technologies for the minimally invasive treatment of abdominal aortic aneurysms (AAA) and thoracic aortic conditions. The company is known for its Ovation System, which includes a stent graft platform designed for endovascular aortic repair. Key components of the Ovation System feature an aortic body, iliac limbs, and polymer fill, which contribute to its effectiveness in treating AAA. TriVascular markets its products through direct sales in the United States and several European countries, as well as via distributors in other regions. Founded in 2007 and headquartered in Santa Rosa, California, TriVascular has been recognized for its innovative approach to addressing unmet clinical needs in aortic disease treatment. The company operates as a subsidiary of Endologix Inc.

Alder BioPharmaceuticals is a clinical-stage biopharmaceutical company focused on discovering, developing, and commercializing therapeutic antibodies to improve treatment for migraine patients in the United States, Australia, and Ireland. The company's lead candidate, eptinezumab, is a monoclonal antibody targeting calcitonin gene-related peptide, currently in late-stage clinical development for migraine prevention. Alder is also developing ALD1910, a preclinical monoclonal antibody aimed at inhibiting pituitary adenylate cyclase-activating polypeptide-38 for similar purposes, and Clazakizumab, which targets the pro-inflammatory cytokine interleukin-6 and has completed two Phase 2b trials. In addition to its product development efforts, Alder engages in strategic collaborations, notably with CSL Limited for advancing clazakizumab as a treatment for solid organ transplant rejection. Incorporated in 2002 and headquartered in Bothell, Washington, Alder operates primarily in the United States, where it generates most of its revenue.

Sequent Medical, Inc. is a medical device company focused on developing catheter-based neurovascular technologies. Founded in 2007 and headquartered in Aliso Viejo, California, with operations in Bonn, Germany, the company has created the proprietary Microbraid technology, which is integral to its WEB Aneurysm Embolization System. This system provides a versatile option for treating both ruptured and unruptured intracranial aneurysms and has received CE mark approval. The WEB device has been successfully used to treat nearly 600 aneurysms across Europe, Latin America, and New Zealand, although it is not available for sale or use in the United States. Sequent Medical, Inc. operates as a subsidiary of MicroVention, Inc.

Calithera Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule drugs targeting tumor metabolism and immunology for cancer treatment. The company's lead candidate, CB-839, is a glutaminase inhibitor currently in Phase II clinical trials aimed at treating solid tumors. Additionally, Calithera is advancing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology. Other notable projects include CB-280, intended for cystic fibrosis treatment, and CB-708, an inhibitor of CD73. The company has established collaborations, including a license agreement with Mars, Inc. for the development of arginase inhibitors and a clinical trial partnership with Bristol-Myers Squibb to evaluate nivolumab in combination with CB-839. Founded in 2010, Calithera is focused on building a pipeline of innovative cancer therapeutics that address critical pathways necessary for tumor growth and survival.

Pivot Medical is a privately held medical device company that specializes in developing and marketing innovative technologies for the orthopedic market. The company focuses on creating minimally invasive hip-replacement devices and advancing arthroscopic surgery techniques. Its products are designed to enhance surgical access and reduce recovery times for patients. Pivot Medical aims to address the needs of active individuals seeking effective treatment options while minimizing the impact of surgery on their daily lives.

Relypsa, Inc. is a biopharmaceutical company based in Redwood City, California, specializing in the development and commercialization of late-stage medicines for conditions primarily in the iron deficiency, nephrology, and cardio-renal therapeutic areas. The company is known for its product VELTASSA, a potassium binder designed to treat hyperkalemia. Relypsa focuses on discovering and developing non-absorbed polymeric drugs that address cardiovascular and renal diseases, particularly conditions that are often overlooked or undertreated. Established in 2007, Relypsa operates as a subsidiary of Vifor Pharma Ltd.

PolyRemedy offers integrated wound management systems designed to increase consistency by extending wound care expertise to the point of care. The PolyRemedy Personalized Woundcare System (PWS) enables clinicians to document care through easy-to-use, web-based assessment tools and order personalized wound dressings, while also providing critical and unprecedented visibility into wound care data. It was founded in 2004 and is headquartered in Concord, Massachusetts.

AEGEA Medical, Inc. is a medical technology company based in Menlo Park, California, focused on improving women's healthcare through innovative treatment options. The company has developed a water vapor ablation system, known as Mara, which provides a safe and effective method for endometrial ablation to treat heavy menstrual bleeding, or menorrhagia. This FDA-approved technology allows for a straightforward, office-based procedure that typically takes only minutes to perform. AEGEA is dedicated to enhancing patient outcomes and expanding access to effective therapies, while also supporting physicians in delivering these procedures with confidence and ease. Founded in 2008, AEGEA Medical is committed to pioneering advancements in women’s health.

Cameron Health, Inc. is a development-stage medical device company focused on creating advanced implantable electronic devices aimed at improving patient care in the field of cardiac health. The company specializes in the development and manufacturing of subcutaneous implantable defibrillator (S-ICD) systems designed for patients at risk of life-threatening ventricular tachyarrhythmias. Their product line includes the SQ-RX pulse generator, which is essential for managing cardiac arrhythmias, and the Q-TRAK subcutaneous electrode, designed for optimal placement within the body. Additionally, the Q-TECH programmer enables wireless communication with the SQ-RX device, enhancing device functionality. Cameron Health's mission is to address unmet medical needs through innovative technology, leveraging the expertise of its team to tackle complex medical challenges.

PixelOptics was founded in 2005 as the world's first composite lens company. Their unique and proprietary approach to lens design combines sound lens design principles and well-known, proven lens materials to create entirely new categories of eyeglass lenses.

Astute Medical, Inc. is a life science tools company specializing in the discovery and development of protein biomarkers for rapid diagnosis and risk assessment of acute medical conditions. Founded in 2007 and based in San Diego, California, with a location in Paris, France, the company focuses on validating prognostic biomarkers related to conditions such as abdominal pain, acute coronary syndromes, cerebrovascular injury, kidney injury, and sepsis. Its primary product, NephroCheck, is a single-use cartridge designed to detect biomarkers of acute kidney injury, while the Astute140 meter converts the fluorescent signals from the NephroCheck cartridge into a single numerical result. Astute Medical's products are marketed in the United States and Europe and aim to enhance clinical decision-making and patient outcomes. As of April 2018, Astute Medical operates as a subsidiary of bioMérieux S.A.

EBR Systems, Inc. is focused on developing innovative implantable devices for cardiac rhythm management, specifically aimed at treating patients with heart failure and cardiac arrhythmias. The company's flagship product, the Wireless Cardiac Stimulation of the Left Ventricle System, utilizes proprietary wireless technology to provide endocardial pacing for cardiac resynchronization therapy. This approach enhances the heart's pumping efficiency by synchronizing the contractions of the left and right ventricles. Founded in 2003 and headquartered in Sunnyvale, California, EBR Systems is committed to advancing therapeutic options for patients suffering from cardiac rhythm diseases through its novel technologies.

ELENZA, Inc. is a medical technology company specializing in the development and commercialization of electro-active AutoFocal intraocular lenses (IOLs) aimed at addressing the cataract extraction market and the correction of presbyopia. Founded in 2008 and headquartered in Roanoke, Virginia, with an additional office in Zürich, Switzerland, ELENZA's innovative IOLs are designed to provide patients with a complete visual range, effectively correcting near, intermediate, and distance vision. Utilizing a proprietary combination of liquid-crystal chemistry, electricity, and integrated circuitry, these lenses feature an electro-active switchable element that automatically adjusts focusing power in milliseconds, ensuring constant in-focus vision across various working conditions and light environments. The technology is powered by a micro-sized power cell with an anticipated rechargeable cycle life exceeding 50 years, positioning ELENZA at the forefront of the multi-billion dollar IOL market.

NeurAxon, Inc. is a Canadian company focused on discovering and developing therapeutics for pain management by targeting neuronal nitric oxide synthase. Founded in 2004 and headquartered in Toronto, NeurAxon is advancing a pipeline of oral products aimed at treating various pain conditions, including acute migraine, neuropathic pain, chronic daily headache, inflammatory pain, migraine prophylaxis, and severe pain. By utilizing selective inhibitors of nitric oxide synthase, the company seeks to provide effective solutions for individuals suffering from these conditions.

Relypsa, Inc. is a biopharmaceutical company based in Redwood City, California, specializing in the development and commercialization of late-stage medicines for conditions primarily in the iron deficiency, nephrology, and cardio-renal therapeutic areas. The company is known for its product VELTASSA, a potassium binder designed to treat hyperkalemia. Relypsa focuses on discovering and developing non-absorbed polymeric drugs that address cardiovascular and renal diseases, particularly conditions that are often overlooked or undertreated. Established in 2007, Relypsa operates as a subsidiary of Vifor Pharma Ltd.

NeuroVista Corporation is a medical device company based in Seattle, Washington, focused on developing innovative technologies for the management and treatment of epilepsy, a condition impacting approximately 3 million individuals in the United States. The company provides advisory technologies designed to reduce the uncertainty surrounding the onset of epileptic seizures, which can vary in severity from brief lapses of awareness to severe convulsions. Founded in 2002 and originally known as BioNeuronics Corporation, NeuroVista rebranded in 2007 to emphasize its commitment to addressing the challenges faced by those affected by epilepsy, a neurological disorder that predominantly affects individuals aged 15 to 64.

TriVascular Technologies, Inc. is a medical device company focused on developing and commercializing technologies for the minimally invasive treatment of abdominal aortic aneurysms (AAA) and thoracic aortic conditions. The company is known for its Ovation System, which includes a stent graft platform designed for endovascular aortic repair. Key components of the Ovation System feature an aortic body, iliac limbs, and polymer fill, which contribute to its effectiveness in treating AAA. TriVascular markets its products through direct sales in the United States and several European countries, as well as via distributors in other regions. Founded in 2007 and headquartered in Santa Rosa, California, TriVascular has been recognized for its innovative approach to addressing unmet clinical needs in aortic disease treatment. The company operates as a subsidiary of Endologix Inc.

BARRX Medical, Inc. specializes in developing endoscopic treatment solutions for Barrett's esophagus, a precancerous condition linked to gastroesophageal reflux disease (GERD). The company offers advanced ablation systems, including HALOFLEX, HALO360, and HALO90, which utilize a balloon-based electrode to deliver a uniform and controlled ablation effect aimed at removing diseased tissue and promoting the regrowth of healthy cells. Clinical studies have demonstrated the effectiveness of these systems, showing high rates of complete eradication of dysplasia and intestinal metaplasia, along with a significant reduction in disease progression and cancer development. The HALO systems have received FDA clearance for use in the United States and hold CE Mark approval for Europe. To date, more than 58,000 procedures have been successfully performed in over 400 hospitals globally. Founded in 2000 and based in Sunnyvale, California, BARRX Medical is a privately-held company committed to addressing chronic gastroenterological diseases.

Calithera Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule drugs targeting tumor metabolism and immunology for cancer treatment. The company's lead candidate, CB-839, is a glutaminase inhibitor currently in Phase II clinical trials aimed at treating solid tumors. Additionally, Calithera is advancing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology. Other notable projects include CB-280, intended for cystic fibrosis treatment, and CB-708, an inhibitor of CD73. The company has established collaborations, including a license agreement with Mars, Inc. for the development of arginase inhibitors and a clinical trial partnership with Bristol-Myers Squibb to evaluate nivolumab in combination with CB-839. Founded in 2010, Calithera is focused on building a pipeline of innovative cancer therapeutics that address critical pathways necessary for tumor growth and survival.

Anulex Technologies focus on developing proprietary medical technology to repair and seal the soft tissue of the spine (anulus) for patients undergoing a surgical procedure to remove a herniated disc (discectomy).

Breathe Technologies, Inc. is a medical technology company based in Irvine, California, that specializes in developing and manufacturing innovative respiratory therapies for treating respiratory insufficiency diseases. Founded in 2005, the company focuses on creating non-invasive open ventilation systems aimed at helping patients with conditions such as interstitial lung diseases, neuromuscular disorders, and those undergoing lung transplants. Their lightweight, volume-control mechanical ventilators are designed to enhance patient mobility and are suitable for use in various healthcare settings, including general medical units, intensive care, and pulmonary rehabilitation. As a subsidiary of Hill-Rom, Breathe Technologies is committed to providing reliable and accessible solutions that optimize breathing and improve the quality of life for patients both in hospital and home environments.

Astute Medical, Inc. is a life science tools company specializing in the discovery and development of protein biomarkers for rapid diagnosis and risk assessment of acute medical conditions. Founded in 2007 and based in San Diego, California, with a location in Paris, France, the company focuses on validating prognostic biomarkers related to conditions such as abdominal pain, acute coronary syndromes, cerebrovascular injury, kidney injury, and sepsis. Its primary product, NephroCheck, is a single-use cartridge designed to detect biomarkers of acute kidney injury, while the Astute140 meter converts the fluorescent signals from the NephroCheck cartridge into a single numerical result. Astute Medical's products are marketed in the United States and Europe and aim to enhance clinical decision-making and patient outcomes. As of April 2018, Astute Medical operates as a subsidiary of bioMérieux S.A.

Tandem Diabetes Care, Inc. is a medical device company headquartered in San Diego, California, which specializes in the design, development, and commercialization of insulin delivery systems for individuals with insulin-dependent diabetes. Its flagship product, the t:slim X2 insulin delivery system, includes a pump, a 300-unit disposable insulin cartridge, and an infusion set. The company offers advanced features such as Basal-IQ Technology and Control-IQ Technology, along with the Tandem Device Updater for software enhancements. Additionally, Tandem provides the t:connect web-based data management application and the Sugarmate mobile app to support diabetes management for users and their caregivers. Tandem Diabetes Care entered the insulin pump market in 2012 and has since expanded its product line, including the recent launch of the smaller Mobi pump and development of a tubeless pump. The majority of the company’s revenue is generated in the United States, with additional sales from other developed countries.

EBR Systems, Inc. is focused on developing innovative implantable devices for cardiac rhythm management, specifically aimed at treating patients with heart failure and cardiac arrhythmias. The company's flagship product, the Wireless Cardiac Stimulation of the Left Ventricle System, utilizes proprietary wireless technology to provide endocardial pacing for cardiac resynchronization therapy. This approach enhances the heart's pumping efficiency by synchronizing the contractions of the left and right ventricles. Founded in 2003 and headquartered in Sunnyvale, California, EBR Systems is committed to advancing therapeutic options for patients suffering from cardiac rhythm diseases through its novel technologies.

PTC Therapeutics, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of orally administered small-molecule therapeutics for the treatment of rare disorders and cancer. The company offers Translarna, used for nonsense mutation Duchenne muscular dystrophy in ambulatory patients, and Emflaza, a corticosteroid for the same condition. PTC Therapeutics is advancing several candidates in clinical development, including Translarna for other rare genetic conditions, RG7916 and RO7034067 for spinal muscular atrophy, and PTC596 and PTC299, which target cancer through dihydrooratate dehydrogenase inhibition. Additionally, the company is developing a gene therapy candidate, PTC-AADC, for Aromatic L-amino acid decarboxylase deficiency. PTC Therapeutics collaborates with various organizations, including F. Hoffman-La Roche Ltd and Massachusetts General Hospital, to further its research and commercialization efforts. Founded in 1998, the company is headquartered in South Plainfield, New Jersey.

TriVascular Technologies, Inc. is a medical device company focused on developing and commercializing technologies for the minimally invasive treatment of abdominal aortic aneurysms (AAA) and thoracic aortic conditions. The company is known for its Ovation System, which includes a stent graft platform designed for endovascular aortic repair. Key components of the Ovation System feature an aortic body, iliac limbs, and polymer fill, which contribute to its effectiveness in treating AAA. TriVascular markets its products through direct sales in the United States and several European countries, as well as via distributors in other regions. Founded in 2007 and headquartered in Santa Rosa, California, TriVascular has been recognized for its innovative approach to addressing unmet clinical needs in aortic disease treatment. The company operates as a subsidiary of Endologix Inc.

BaroSense is focused on developing and commercializing innovative medical devices aimed at addressing obesity, a significant healthcare challenge in the United States. The company aims to provide safe, simple, and effective alternatives to surgical treatments for obesity, catering to individuals who require assistance beyond traditional dieting methods and wish to avoid extensive and irreversible surgical options. BaroSense's product offerings include minimally invasive therapeutic procedures and devices, such as a trans-oral endoscopic restrictive implant system, designed to facilitate weight loss in a less invasive manner.

VytronUS, Inc. specializes in the manufacture and marketing of cardiac medical devices aimed at treating cardiac arrhythmias. Founded in 2006 and located in Sunnyvale, California, the company focuses on leveraging ultrasound energy to enhance the imaging and therapeutic capabilities of its devices. These innovative products allow for precise non-contact energy delivery and facilitate the production of high-resolution maps of cardiac anatomy. By providing physicians with tools that enable visualization, precision, flexibility, and automation, VytronUS aims to improve the treatment of complex arrhythmias.

Anulex Technologies focus on developing proprietary medical technology to repair and seal the soft tissue of the spine (anulus) for patients undergoing a surgical procedure to remove a herniated disc (discectomy).

PhotoThera is currently hiring for the following positions: Sr. Software Engineer Mechanical Engineer Configuration Management Engineer Sr. Electrical Engineer Send your resume and cover letter to ktitano@photothera.com, or go to www.photothera.com for further information. Specialties laser, medical device, eschemic, stroke, infrared