MassChallenge

Stellar Project is a space technology startup that offers game-changing solutions for light satellites. It specializes in laser communication in the space and space economy. It is located in Padua, Veneto.

Developer of an interferometry technology platform designed to generate images. The company's platform specializes in microfabrication, X-ray, and neutron grating interferometry which can generate information through the interaction of electromagnetic waves, enabling industries to improve the performance of gratings with support structures.

FLITE has a laser-based technology that changes the surface topology of familiar materials (glass, plastic, metal, ceramics and semiconductors) to make them attract or repel water and oil - without the use of chemical coatings.

Spirecut specializes in the development of innovative surgical instruments aimed at improving hand surgery standards and enhancing patient recovery. The company's flagship product, the patented Sono-Instruments, enables percutaneous release procedures under sonographic guidance in adult patients. Typically performed in outpatient settings using local anesthesia, these procedures feature minimal morbidity, allowing patients to quickly return to their normal activities. The Sono-Instruments enhance traditional needling techniques used by surgeons and radiologists, providing a specially designed tool that facilitates the safe release of thickened tissue while ensuring effective preoperative sonographic tracking. This improved visualization during surgery reduces the risk of unintentional injury to surrounding anatomical structures, ultimately optimizing surgical outcomes.

SlitLED Israel is a 3D & digital, mobile eye-examination system operating remotely and in real-time.

Rayito de Luna is a Mexican company that develops beauty and personal care products for women and men. It is an eco-friendly 100% natural personal care brand, that practices fair trade and supports the development of local independent producers.

TomoWave is a company focused on developing innovative imaging technologies for clinical medicine and preclinical research. Utilizing its proprietary optoacoustic and laser ultrasonic imaging modalities, TomoWave aims to enhance cancer detection, guide medical interventions, and monitor the effectiveness of cancer therapies. The company's technology, which captures images by "listening to the sound of light," allows for highly detailed visualization of tissues, particularly in relation to vascular and blood-related conditions. Founded by Dr. Alexander Oraevsky, a pioneer in biomedical optoacoustics, TomoWave has a strong emphasis on generating intellectual property and advancing it from concept to validated clinical prototypes. The company is committed to bringing its technologies to market through appropriate regulatory certifications, thus contributing to improved diagnostic capabilities in healthcare.

EarlySight SA is a Swiss company, established in 2016 and based in Lausanne, that focuses on developing innovative medical devices for the early detection and treatment of eye diseases. The company has created an advanced eye fundus camera that enhances retinal imaging through precise illumination and real-time correction of ocular aberrations. This device utilizes cellular-level imaging technology to identify subtle structural changes in the retina, allowing for effective monitoring of treatment outcomes in a quick and non-invasive manner. By facilitating the visualization of cell morphology within the retina, EarlySight aims to improve the capabilities of eye specialists in diagnosing and managing ocular conditions.

VisusNano Ltd. is a pre-clinical company based in London, United Kingdom, focused on developing a drug-eluting intraocular lens implant for cataract surgery. Founded in 2016, the company aims to enhance patient outcomes by reducing the risks associated with cataract procedures, such as intraocular inflammation, infection, and opacification. This innovative lens technology eliminates the need for postoperative eye drops and laser treatments, positioning it as a potential game-changer in both human and veterinary cataract surgery markets. Through its advancements, VisusNano seeks to revolutionize the standard of care in ophthalmic procedures.

Lab-on-Fiber GmbH engages in the development, commercialization, and production of fiber delivery and laser systems. It offers surgical fiber probes and urology fiber probes. Lab-on-Fiber GmbH is based in Halle, Germany.

Nodar, Inc. specializes in manufacturing advanced sensors for various transportation modes, including cars, trucks, drones, ships, trains, and aircraft. The company offers innovative LiDAR technology and a 3D stereo vision system called Nodar Longbow, which is designed to enhance the capabilities of autonomous vehicles. Founded in 2018 and based in Boston, Massachusetts, Nodar aims to provide a cost-effective and high-performance solution for the automotive, marine, and railway industries. Their products, including the Hammerhead system, utilize off-the-shelf cameras to deliver precise depth sensing, targeting applications for level 3 and level 4 autonomous vehicles. This technology supports functions such as collision warning, path planning, and automatic emergency braking, contributing to improved safety and performance in the automotive sector.

LuminDx, Inc. is a Boston-based company that specializes in developing a mobile application designed to assist physicians in visually diagnosing skin conditions through the use of computer vision and artificial intelligence. The application allows patients to take photographs of their skin issues, answer straightforward questions, and receive immediate feedback on similar skin diseases along with guidance on relevant inquiries for further evaluation. By leveraging a database of one million diagnosed images, LuminDx aims to enhance the diagnostic capabilities of healthcare providers, helping to analyze clinical symptoms and potentially reduce unnecessary prescriptions, treatments, and referrals to dermatologists. Incorporated in 2017, LuminDx is focused on improving patient outcomes in the realm of dermatology.

Dermafence develops an innovative technology for the treatment of energy-mediated skin injuries and burns. Its devices are a kind of liquid bandages that form a thin layer on skin upon application and prevent the progression of wounds after burns following the absorption of any kind of energy that include thermal, mechanical, radiation, and laser-mediated burn injuries. It was founded in 2017 and is based in Jerusalem, Yerushalayim, Israel.

Lymphatica Medtech SA is a medical device company based in Lausanne, Switzerland, founded in 2017. The company specializes in developing minimally invasive solutions for chronic lymphedema, a condition characterized by persistent swelling in the limbs due to a blockage in the lymphatic system. This blockage commonly results from lymph node damage during cancer treatment. Lymphatica offers the LymphoDrain system, which includes an implantable magnetically controlled micropump and various components such as subcutaneous catheters and a wearable controller. This innovative device aims to restore lymphatic circulation by internally draining lymphatic fluid from multiple points in the affected limb, providing patients with an effective long-term solution to manage their condition and improve their quality of life.

Cellino Biotech, Inc. is a biotechnology company based in Cambridge, Massachusetts, founded in 2017. It specializes in intracellular delivery lasers and nanotechnology specifically for gene editing applications. The company has developed an AI-guided laser editing platform that automates the generation of personalized, autologous cell therapies, significantly reducing the development time of engineered cells from years to weeks. By integrating advanced tools from optics, biology, and computation, Cellino makes stem cell differentiation a digital process, allowing healthcare providers to efficiently produce functionally mature cells at scale. This innovative approach aims to enhance the accessibility of life-saving medicines for patients.

LambdaVision, Incorporated is focused on developing a protein-based artificial retina aimed at restoring vision for individuals affected by advanced retinal degenerative diseases, such as retinitis pigmentosa and age-related macular degeneration. Founded in 2009 and located in Farmington, Connecticut, the company is working to commercialize its retinal implant technology, which employs a light-activated protein known as bacteriorhodopsin. This innovative approach targets the stimulation of retinas in patients who have experienced significant sight loss, with the goal of enhancing their quality of life. Through its advancements, LambdaVision seeks to address the needs of millions who suffer from these debilitating conditions.

Plasmatica uses a very unique technology that help save patients lives and maintain the surgeon peace of mind. Plasmatica solves the problem in laparoscopic surgeries - camera fogging. Laparoscopy has evolved into a surgical standard with many of open surgeries shifting steadily to this surgical procedure, currently surgeries are performed annually worldwide. Using breakthrough plasma technology, Plasmatica eliminates the problem and maintain a clear view for the whole operation. By a simple and single pre-op treatment, done by the nurse, they make the surgeon forget the problem ever existed.

LightForce Orthodontics addresses this problem by applying patented, next-generation manufacturing technology adapted for use in orthodontic treatment by the industry's leading experts. It enables orthodontists to utilize its 3D-printing technology to create custom braces for each individual patient, significantly reducing the number of adjustment visits needed.

Lux Labs develops advanced optical materials using cutting edge nanophotonics and polymer fabrication methods.

uSonik is designed to clean all your teeth in seconds.

Luminopia has created an unparalleled, proprietary treatment device that is safe, fun, and fast in order to improve both vision and quality of life. The company offers treatment for eyes using virtual reality and promotes binocular vision by ensuring that the user sees the content with both eyes.

At SteriLux, they are convinced that their technology will make a real impact on the improvement of the quality of medical care. They are commited to establish an ecological and economical system, which is compliant with all the most demanding medical norms and which is adapatable to every environment.

Rayform SA specializes in advanced light redirection technology that enhances the design potential of luxury products and packaging. Founded in 2016 and located in Ecublens, Switzerland, the company utilizes a proprietary computer algorithm to calculate the three-dimensional surfaces required to project specific target images using light. By adjusting the shape of transparent or reflective surfaces based on these calculations, Rayform enables the redirection of incoming light to create vivid and detailed images on adjacent surfaces. This innovative technology not only offers unique design opportunities for artists and brands but also serves as a means to enhance product security and counterfeiting prevention.

LuminOva aims to provide an accurate method, by offering a device to IVF clinics that images eggs/embryos and illuminates new features associated to viability. They hope to improve success rates by incorporating these features in a selection algorithm that indicates embryo quality.

Orange Photonics, Inc. specializes in providing quality control and data analytics products for the legal cannabis industry. Based in Elkins, New Hampshire, the company develops solutions for a variety of stakeholders, including growers, dispensaries, regulators, and manufacturers of infused products. Its flagship product, the LightLab, is a portable, lab-grade cannabis potency analyzer designed for on-site testing and tracking of cannabis potency. This innovative tool aims to set a new standard for accurate, repeatable, and cost-effective potency testing. In addition to the LightLab, Orange Photonics plans to offer services that facilitate data collection and analysis, enabling customers to make informed, data-driven decisions to enhance their operations within the cannabis market.

Danger!Awesome is designing and launching the world’s first super-powered professional solid-state laser cutter at a consumer price point. Unlike CO2-based laser systems, their device cuts metal and achieves much higher power on all materials, without the $25K-$75K price tag. Hundreds of thousands of users rely on these devices daily - design firms, architects, and universities - are shopping to replace their laser devices with more modern, more powerful, and less expensive machines. They’re now joined by libraries, schools, and community spaces, buying new laser cutters in incredible numbers.

Oral cancer patients often suffer from debilitating damage to healthy tissue during treatment. OralSave's radiation delivery device aims to protect healthy oral tissue, allowing for non surgical, pinpoint radiation therapy with no need for a specially trained maxillofacial prosthodontist. The device is patient-specific and manufactured rapidly using 3D printing. For patients around the world, this could result in retaining the ability to eat, taste, swallow and produce saliva.

Newton Photonics is developing a truly non-invasive blood glucose monitor for diabetes patients. Newton Photonics is developing a non-invasive glucose monitor for diabetes patients. Their mission is to make self-testing of blood glucose as convenient and painless as blood oxygen testing with a pulse oximeter. Their glucose monitor is based on the company's proprietary optical sensing technology, which has been validated in two blind human trials. They currently seeks $200,000 to build and test their next generation prototype that will be more accurate, faster and smaller.

Keraderm Corp. is dedicated to harnessing the healing power of light to treat a wide variety of skin and nail infections and disorders. There proprietary phototherapy treatment has shown potential efficacy in pilot clinical trials and is the only germicidal light nail treatment that has been awarded patents.

Fluorescent Nanoscopy is a breakthrough technology for optical microscopy suited for live cell imaging with tens times enhanced resolution. It helps develop new drugs and materials, achieve breakthrough results in fundamental research and to improve clinical and QA tests. This can be done by both increasing resolution in cell research and increasing data density on surfaces of microarrays. The technology has a strong IP protection and gives an opportunity to create new markets.