Massachusetts Capital Resource Company, founded in 1977 and based in Boston, Massachusetts, serves as a private investment firm focused on addressing the funding gap for growing companies. The company provides risk capital in the form of mezzanine financing, long-term debt, and equity investments, specifically targeting emerging growth and middle-market firms. Its primary sectors of interest include manufacturing, distribution, service, and technology. By offering tailored investment solutions, Massachusetts Capital complements the financing available from senior lenders and equity investors, thereby supporting the growth and acquisition needs of companies operating in Massachusetts.

MassChallenge is a global startup accelerator supporting early-stage entrepreneurs across various industries. Founded in 2009, it provides mentorship, resources, and networking opportunities through its programs worldwide.

The National Science Foundation (NSF) is an independent federal agency established in 1950 and based in Alexandria, Virginia. It is dedicated to supporting research and education in science and engineering across a wide range of disciplines. The NSF provides significant non-dilutive funding, up to $1.5 million, to startups and small businesses through its America's Seed Fund initiative, which is part of the Small Business Innovation Research (SBIR) program mandated by Congress. With an operating budget of approximately $7.8 billion, the NSF is committed to advancing fundamental research and education, thus fostering innovation and technological development in the United States.

MassVentures is a venture capital firm based in Waltham, Massachusetts, established in 1978 as a quasi-public corporation by the Massachusetts Legislature. The firm focuses on providing seed and early-stage funding to high-growth startups, facilitating their transition from concept to commercialization. MassVentures invests primarily in sectors such as information technology, healthcare, cybersecurity, e-commerce, mobile, manufacturing, and robotics. With a governance structure that includes an independent Board of Directors and management by experienced venture capitalists, MassVentures leverages the state's entrepreneurial spirit and innovation centers to support the Massachusetts innovation economy. The firm also offers accelerator programs to further assist emerging companies in their growth journey.

Founded in Boston in 2004, RA Capital is an investment firm specializing in life sciences and drug development. Its team, with backgrounds in biology, chemistry, medicine, and industry experience, invests in early-stage companies with promising technologies and products across healthcare and life science sectors.

Polaris Partners is a venture capital firm based in Boston, Massachusetts, with offices in San Francisco. Founded in 1996, it targets investments in technology and life science companies across the United States and Europe, supporting startups from early formation to profitable growth. The firm's healthcare and biotechnology focus encompasses digital health, consumer-centric care delivery, patient-provider solutions, data science and analytics, as well as therapeutics, genomics and other life science platforms. It backs companies across business-to-business and business-to-consumer models, software as a service, healthcare information technology and health tech sectors, partnering with repeat entrepreneurs to build durable, scale-ready businesses.

Founded in 2000, General Catalyst is a venture capital firm specializing in early-stage and growth equity investments. It focuses on accelerating ideas, careers, and companies towards success by providing ongoing momentum and mentorship based on deep experience.

Founded in 1980, Atlas Venture is an early-stage venture capital firm based in Cambridge, Massachusetts. It focuses on creating and investing in biotech startup companies led by promising entrepreneurs, with a seed-led venture creation strategy that rigorously selects compelling opportunities to build scalable businesses in life sciences innovation.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, with offices across North America. It provides access to venture investing for individual accredited investors, particularly alumni networks, by offering diversified portfolios of venture opportunities and allowing members to invest alongside fellow alumni in ventures led by peers. The firm backs early-stage and later-stage opportunities across technology, consumer, healthcare, financial services, and other sectors, with a sector- and geography-agnostic approach. It typically invests between $10,000 and $3 million per deal and emphasizes the involvement of alumni connections and an institutional lead investor in opportunities. Alumni Ventures also offers focused funds to broaden participation, enabling accredited investors to access venture portfolios diversified by type, sector, stage, and geography. The model aims to democratize access to venture capital while maintaining rigorous selection standards through alumni networks.

Google is a multinational technology company renowned for its search engine, offering services such as Gmail, Google Drive, Google Docs, and YouTube. It specializes in advertising solutions through Google Ads and mobile operating systems with Android, while actively innovating in artificial intelligence and machine learning.

Bain Capital is a Boston-based private, multi-asset investment firm that manages assets across private equity, public equity, credit, and venture capital. Founded in 1984, it operates multiple units that create value by supporting companies across sectors such as technology, healthcare, life sciences, financial services, consumer, and industrials, through growth equity, buyouts, early-stage venture capital, and other investment approaches.

Founder Collective is a seed and early-stage venture capital firm founded in 2009 with roots in Cambridge, Massachusetts and offices in New York. The firm is built by entrepreneurs who have founded and exited technology companies, and it aims to back founders by providing practical capital and guidance to navigate the risks of venture funding. It concentrates on early investments in technology companies, with an emphasis on software and information technology, and it makes bets across the United States and beyond, though its roots are on the East Coast. The team partners with portfolio companies to help them scale, often supporting startups that seek modest initial financings. Through its network and hands-on approach, Founder Collective seeks to partner with ambitious teams to grow durable, technology-driven businesses.

Established in 2009, the Massachusetts Clean Energy Center is a state agency dedicated to accelerating clean energy development and implementation. It aims to create high-quality jobs and long-term economic growth by facilitating renewable energy generation projects and developing a skilled workforce.

Founded in 1986, Morningside Group is a venture capital firm based in the greater Boston area. It invests in companies with innovative science and technology across life sciences, digital health, AI, materials, and technology sectors.

New Enterprise Associates is a venture capital firm founded in 1977 and based in Menlo Park, California, with offices in the United States, India and China. It makes investments across technology and healthcare startups at multiple stages, from seed to growth, including software, cloud, data, internet services, fintech, AI, e-commerce, and enterprise technology, as well as healthcare information technology, life sciences, medical devices, and biopharma. It also considers energy technology and infrastructure opportunities, such as solar, batteries and smart grids. The firm pursues a global approach, with activity in the United States, Asia and other regions, and supports companies through rounds of financing ranging from small to sizable investments as they scale. NEA focuses on building portfolios in software, IT services, consumer technology, and healthcare technology, backing ambitious entrepreneurs across sectors and geographies.

The U.S. Department of Energy is a government agency established in 1977, located in Washington, D.C. Its primary mission is to ensure the security and prosperity of the nation by tackling energy, environmental, and nuclear challenges. The Department focuses on promoting transformative scientific and technological solutions to address these issues, thereby supporting the country's energy needs and environmental sustainability.

Founded in 1986, ARCH Venture Partners is a venture capital firm specializing in investments that bring innovations in life sciences to market. It focuses on companies co-founded by scientists and entrepreneurs, with a strong track record in commercializing technologies from academic research institutions and national laboratories.

Accomplice is a Boston-based venture capital firm, with an additional office in San Francisco, specializing in seed and early-stage investments in technology startups. It primarily invests in companies focused on cybersecurity, eSports, data analytics, SMB class software, emerging hardware platforms, and marketplaces. Accomplice uniquely leverages community platforms like AngelList, Boston Syndicates, and Maiden Lane to empower and fund exceptional founders. With a majority of its investments in Boston and additional investments throughout the U.S., Canada, and the E.U., Accomplice is one of the most active early-stage firms in New England.

Insight Partners is a global software investor that partners with growth-stage technology and software companies. The firm focuses on growth-stage software, internet, and data services, with emphasis on fintech, cybersecurity, artificial intelligence and machine learning, DevOps, and healthcare. Based in New York City with offices in London, Tel Aviv, and Palo Alto, Insight Partners has backed more than 750 companies worldwide and has more than 55 portfolio companies that have achieved an IPO. As of 2022, the firm reports over $75 billion in assets under management. It seeks to fund and work closely with visionary executives, providing practical, hands-on software expertise to support growth from initial investment through to IPO.

Founded in 1999, Perceptive Advisors is a New York-based investment firm focused on the life sciences sector. It invests across various stages of company development, from seed to late-stage ventures and public equities, with a typical investment size ranging from $10 million to $200 million. The firm employs long/short equity strategies and conducts in-house research to identify promising opportunities in biotechnology, pharmaceuticals, life sciences, and healthcare services.

Founded in 1989, OrbiMed is a New York-based healthcare-dedicated investment firm managing approximately $5 billion in assets. It invests across the spectrum of healthcare companies, from private start-ups to large multinational corporations, focusing on biopharmaceuticals, life sciences, digital health, medical devices, and diagnostics sectors globally.

Alexandria Venture Investments is the strategic venture capital arm of Alexandria Real Estate Equities. Based in Pasadena, California, it provides long-term strategic capital to innovative life sciences and technology companies developing breakthrough therapies, diagnostics, and platforms across biopharma, digital health, agrifoodtech, agtech, and related healthcare fields. Established in 1996, the firm invests across seed, early, and growth stages and leverages its deep industry knowledge, extensive investor networks, and scientific advisory resources to support portfolio companies. The unit also pursues opportunities at the intersection of real estate, life sciences, and technology, reflecting its parent company's sector focus and integrated ecosystem approach. It aims to help entities advance human health by partnering with founders to scale transformative technologies.

Mission BioCapital is a life science venture capital firm investing in early-stage companies within the biotechnology sector. Founded in Cambridge, Massachusetts in 2009, the company is known for its experienced leadership team and deep support provided to portfolio companies.

Founded in 1969, F-Prime Capital is a venture capital firm based in Cambridge, Massachusetts. It invests globally in technology and healthcare sectors, supporting entrepreneurs with its extensive domain expertise and relationships.

.406 Ventures, established in 2005 and headquartered in Boston, is a venture capital firm focusing on early-stage investments in the Northeast United States. The company specializes in enterprise IT sectors, with a particular interest in information technology security and infrastructure, cybersecurity, digital health, and next-generation software. They typically invest between $2 million to $5 million initially, with a total commitment of up to $10 million per company, often taking a minority or control stake and seeking board representation. As lead, first institutional investors, they aim to support market-changing companies and apply their industry expertise and networks to create value for entrepreneurs and partners.

Battery Ventures is a technology-focused investment firm founded in 1983 and based in Boston, Massachusetts. It invests through venture capital and private equity, targeting technology companies that can become category-defining leaders in areas including application software, IT infrastructure, consumer internet and mobile services, industrial technologies, and life sciences tools.

Flagship Pioneering is a Cambridge, Massachusetts-based venture creation firm that conceives, creates, resources, and grows first-in-category companies across health technology, biotechnology, medicine, engineering, energy, and related fields. The organization aims to transform human health and sustainability by turning seemingly unreasonable ideas into transformational ventures through an evolutionary, science-driven approach. It combines inventive capacity, entrepreneurial leadership, and capital management within a single enterprise to systematically build new companies that pursue breakthrough advances in biology, engineering, and medicine. Since its founding in 2000, Flagship Pioneering has developed and nurtured a portfolio of ventures by integrating scientific discovery with disciplined entrepreneurship, seeking to accelerate innovations from concept to market.

SV Health Investors is a venture capital and growth equity firm focused on healthcare and life sciences. Headquartered in the United States with offices in Boston, San Francisco and London, the firm supports entrepreneurs who develop breakthrough medicines, devices and related technologies. It manages multiple private healthcare funds and has a 20-year track record in the US and Europe, investing across North America and Western Europe to advance innovative treatments and diagnostics. SV Health Investors aims to transform healthcare by backing early-stage and growth opportunities in biotechnology, medical devices and related sectors.

Casdin Capital is a New York‑based investment firm founded in 2012 by Eli Casdin. The firm specializes in fundamental research and long‑short equity strategies focused on the life sciences and healthcare sectors, including oncology, digital health, and agtech. In addition to its public‑market fund, Casdin Capital invests in early‑stage to late‑stage private companies within these industries. It operates as a Registered Investment Adviser and, as of October 2020, managed approximately $2.2 billion in assets.

SoftBank Robotics Europe designs and manufactures humanoid robots for education, research, health, distribution, tourism, and business applications, as well as for family and personal use. The company serves customers worldwide and is based in Paris, France, with additional offices in Japan, the United States, and China.

Founded in 2005, Spark Capital is a venture capital firm that invests across various sectors and stages. Known for embracing risk, the firm supports founders of exceptional products to achieve success on their own terms. Notable investments include Twitter, Discord, Cruise, Niantic, Oculus, Warby Parker, and Tumblr.

Founded in 1971, Schooner Capital is a Boston-based investment firm focusing on growth equity investments. It primarily invests in private companies across various stages and sectors, with a particular interest in alternative energy and clean tech within the United States.

Third Rock Ventures is a Boston-based venture capital firm that specializes in start-up and early-stage investments in life sciences companies, including biotechnology, pharmaceuticals, medical devices, diagnostics, therapeutics, and related information technology and data applications. Founded in 2007, the firm focuses on transformational ventures in the United States and commonly makes substantial initial investments, often leading rounds and pursuing strategic collaborations with larger pharmaceutical and biotechnology companies. It emphasizes active involvement in its portfolio, sometimes taking key management roles to accelerate development, and seeks to support companies through strategic partnerships, milestones, and scale-up efforts. While headquartered in Boston, it maintains a presence in San Francisco to engage with the broader life sciences ecosystem.

Founded in 1983, Accel is a venture capital firm dedicated to helping entrepreneurs build world-class technology-focused companies. It invests in early and growth-stage startups across sectors such as software, cloud technologies, mobile, consumer services, and others.

Matrix Partners is a venture capital firm founded in 1977 and based in San Francisco that backs early-stage and Series A technology companies across sectors such as artificial intelligence, B2B software, consumer technology, fintech, health tech, infrastructure, and semiconductors. The firm emphasizes practical, founder-centered collaboration, often supporting concepts from idea stage through Series A and taking board seats to help portfolio companies scale. It operates globally, including Matrix Partners China, which focuses on long-term relationships with entrepreneurs in China and has a track record of IPOs and strategic exits. The team combines former founders and experienced investors to bring local execution and global perspective. Notable investments span across the technology landscape, reflecting a history of involvement with companies like FedEx, Apple, Oculus, Canva, Zendesk, HubSpot, Postmates, Fivetran, Sila, and GOAT, illustrating the firm’s ability to support companies from early development to scale.

The Massachusetts Life Sciences Center (MLSC) is a quasi-public agency dedicated to fostering innovation within the life sciences sector in Massachusetts. Established under the Massachusetts Life Sciences Act, the Center's mission is to create jobs and enhance scientific research that benefits public health. It provides financial support to both public and private entities engaged in life sciences research, development, and commercialization, focusing on areas such as biopharma, medical devices, diagnostics, and digital health. The MLSC operates an Accelerator Loan Program aimed at offering working capital to early-stage life sciences companies with strong potential for growth and technology commercialization. Through these initiatives, the Center aims to strengthen the ties within the Massachusetts life sciences community and promote economic development driven by innovation.

Pillar VC is a Boston-based venture capital firm founded in 2016 that focuses on partnering with founders from the inception of their ventures. The firm provides initial capital and is dedicated to supporting the growth of both the companies and the founders through connections, coaching, and community engagement. Pillar VC invests across a diverse range of high-potential sectors, including biotechnology, artificial intelligence, hardware, enterprise software, blockchain, digital health, and synthetic biology. By backing both first-time and experienced entrepreneurs, Pillar VC aims to nurture the next generation of impactful companies.

Founded in 1995, SOSV is a global venture capital firm headquartered in New Jersey. It focuses on seed-to-growth stage investments in deep tech innovations, primarily in bio-tech/life sciences and hardware/robotics sectors, with a commitment to human and planetary health.

Founded in 2004, Khosla Ventures is a venture capital firm based in Menlo Park, California. The firm invests in early-stage technology companies across various sectors including AI, climate, enterprise, consumer, fintech, digital health, medtech, therapeutics, and frontier technology.

Beacon Angels is a Boston-based angel group founded in 2006 that specializes in investing in early-stage and fast-growing companies in New England. The firm focuses on making investments ranging from $100,000 to $300,000, targeting businesses with high growth potential. Through its investment strategy, Beacon Angels aims to support and foster the development of small companies, contributing to the entrepreneurial landscape in the region.

Founded in 1851, MassMutual is a mutual life insurance company headquartered in Springfield, Massachusetts. It offers a range of financial services including investment management, trust services, life insurance, disability income insurance, long-term care insurance, annuities, mutual funds, and retirement products.

The Engine is an incubator and venture platform founded by MIT in Cambridge, Massachusetts, launched in 2016. It provides startups with space, streamlined legalities, access to lab space and equipment, and connects to patient capital from investors who share a long-term vision. The Engine offers business planning guidance, enabling startups to move from concept to market quickly. It supports up to 60 locally based startups concurrently through a 12-month accelerator, taking less equity than typical programs to help founders retain control. It connects to MIT resources via the Engine Room, providing resources and expertise. It targets Tough Tech areas such as artificial intelligence, climate and energy, autonomous systems, robotics, biotech and life sciences, and advanced manufacturing, combining science, engineering, and leadership to accelerate path to market and impact.

Bessemer Venture Partners is a historic venture capital firm founded in 1911 and based in Redwood City, California. It invests globally across stages in technology-enabled companies, including software, cybersecurity, fintech, healthcare, AI and machine learning, biotech, cloud, and consumer platforms. The firm supports entrepreneurs from seed to growth and maintains a diversified portfolio that includes notable consumer, enterprise, and fintech companies such as Pinterest, Shopify, Twilio, Yelp, LinkedIn, DocuSign, Wix, Fiverr, and Toast.

Founded in 2002, FlyBridge is a seed-stage venture capital firm based in Boston, Massachusetts. It invests primarily in computer hardware, software, SaaS, and big data sectors, aiming to leverage the power of community with entrepreneurs.

Founded in 2015, Underscore.VC is a Boston-based venture capital firm focusing on seed to series A investments. It primarily invests in technology companies with an emphasis on sensor-related technologies, software for factories and home automation, healthcare infrastructure, data storage databases, and cloud-based marketing/commerce software.

Morningside is a venture capital firm based in the greater Boston area, specializing in investments in companies that focus on innovative science and technology. Established in 1986 as a family office for the Chan family, Morningside emphasizes a long-term approach to company-building and maintains a strong commitment to ethical practices. The firm is staffed by a team of experienced investment professionals with expertise in various sectors, including life sciences, digital health, artificial intelligence, materials, and technology. In addition to its investment activities, Morningside is dedicated to philanthropic efforts, supporting education, research, and healthcare initiatives such as the Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.

Invus Financial Advisors, LLC is an employee-owned investment firm based in New York, founded in 2006. The firm specializes in private equity investments and manages pooled investment vehicles, including hedge funds and funds of funds. Invus focuses on making direct and indirect investments in special situations, venture capital, and growth equity stages, with an emphasis on smaller companies and opportunistic co-investments. The firm adopts a flexible approach, recognizing the uniqueness of each company and the complexities of business transformation. Invus maintains a long-term commitment to its investments, aligning its incentives with those of its partners. With a history of empowering owner-managers since 1985 and a strong backing from a group of European families, Invus Financial Advisors manages over $4 billion in an evergreen fund and operates additional offices in London, Paris, and Hong Kong.

Founded in 2010 and headquartered in Boston, Massachusetts, Boston Seed Capital is a venture capital firm specializing in seed-stage funding for internet-enabled businesses. The firm focuses on consumer goods, business services, technology-related companies, and supporting services marketplaces across the United States.

Samsara BioCapital is a venture capital firm based in Palo Alto, California, that focuses on biotechnology and life sciences companies in the United States. The firm seeks to invest in pharmaceutical and biotechnology ventures, including oncology and other healthcare technologies, with a goal of supporting entrepreneurs in turning ideas into developed therapies. It emphasizes collaboration with ambitious partners and aims to advance biotech innovation and important new therapies by providing capital and advisory support. The organization also operates as a registered investment adviser, offering investment advisory services to guide portfolio companies through growth and development.

Founded in 2010, Longwood Fund is a Boston-based venture capital firm that creates and invests in science-based companies developing innovative solutions for significant medical challenges. The firm typically sources technology from top-tier academic institutions like Harvard and MIT.