Metaphore Biotechnologies use biomimicry and machine learning to unveil the revolutionary medicinal potential of functional molecular mimics. The MIMiCTM platform, developed by the business, is a computationally driven bio platform for developing novel therapies in which function, specificity, and selectivity may be optimized. Metaphore is dedicated to uncovering previously inaccessible pharmacological targets and achieving breakthroughs that exceed today's medications for maximum patient effect.
Apriori Bio is a health security company, aimed at protecting humanity against viral threats. The company uses a unique technology platform that enables the creation of variant-resilient vaccines and provides real-time insights to prepare for future outbreaks. Apriori Bio focuses on designing new vaccines and antibody drugs to combat existing and potential viral variants. With its innovative approach, the company aims to ensure durable protection against rapidly evolving viruses
Tessera Therapeutics is an early-stage life sciences company pioneering Gene Writing, a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.
Vesalius Therapeutics is focused on redefining the understanding and treatment of the diseases that drive ninety percent of human illness.
Generate Biomedicines is a biotechnological company focusing on creating breakthrough medicines. It pioneers in the field of Generative Biology, a revolutionary approach to drug development that allows them to program protein-based modalities for the first time. Generate Biomedicines has proved that its machine-learning platform can generate new biological molecules with therapeutic value, accelerating the drug discovery process.
Alltrna is the tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. tRNAs play a central role in the translation of mRNA into proteins. tRNA biology modulates the complex code of DNA and RNA across translation and transcription. Altrna platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential.
CIBO applies advanced technologies to deliver a deep understanding of agricultural systems to help mitigate climate change, advance food system resilience, and improve grower outcomes through driving the adoption of sustainable practices. CIBO is a 2021 Fast Company World Changing Ideas Awards finalist and was named 2021 AgTech Breakthrough “AI-based AgTech Company of the Year.”
YourBio Health is developing novel products to optimize the interface of diagnostic medicine and the healthcare consumer by dramatically simplifying blood sampling and testing. By eliminating the barriers to the acquisition of critical diagnostic information, Seventh Sense is contributing to the future of informed, effective healthcare delivery and patient participation in their own well-being. The Seventh Sense On Vivo™ platform will enable diagnostic testing to be performed safely and painlessly by virtually anyone, anywhere. Their proprietary, single-step Touch Activated Phlebotomy™ (TAP™) technology can be combined with a variety of diagnostic assays for rapid results. TAP's revolutionary sampling capabilities may also integrate with analytical systems to vastly improve the patient and clinician experience.
Laronde develops an eRNA-based therapeutic platform that is capable of indicating diverse proteins inside the body. It is persistent, non-immunogenic, allows for repeat dosing, and offers flexibility in formulation and delivery. Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. The company is rapidly scaling to support the parallel development of multiple programs across many disease areas.
Ring Therapeutics is a multi-product platform company focused on discovering and developing Anellovector therapeutics to unlock the full potential of gene therapy. Founded by Flagship Pioneering, Ring is pioneering the first redosable and targetable gene therapy platform by harnessing the biology of the human commensal virome. The company is expanding the applications of gene therapy beyond gene replacement, enabling a much wider array of modalities and mechanisms to treat previously inaccessible diseases.
Invaio Sciences is a technology company that is dedicated to unlocking the potential of our planet’s interdependent natural systems to solve pressing agriculture, nutrition, and environmental challenges. Invaio Sciences is a flagship pioneering company startup in Cambridge. They are at the forefront of developing novel technologies based on groundbreaking science with an intent to positively impact their planet by enabling the application of breakthrough solutions in agriculture, human health, animal nutrition and animal health.
Inari Agriculture, Inc. is a biotechnology company that specializes in developing customized seeds through CRISPR gene editing technology, aimed at optimizing crop growth in diverse environmental conditions. Founded in 2016 and based in Cambridge, Massachusetts, Inari focuses on crops such as wheat, soybean, and corn, addressing significant agricultural challenges like climate change. The company employs advanced multiplex gene editing and predictive design to create efficient and sustainable plant breeding solutions, thereby reducing the time and cost associated with traditional breeding methods. Inari's approach aims to enhance agricultural productivity while respecting environmental sustainability, and it collaborates with a diverse team of scientists and partners globally to drive innovation in the agricultural sector.
Laronde develops an eRNA-based therapeutic platform that is capable of indicating diverse proteins inside the body. It is persistent, non-immunogenic, allows for repeat dosing, and offers flexibility in formulation and delivery. Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. The company is rapidly scaling to support the parallel development of multiple programs across many disease areas.
Repertoire Immune Medicines is a clinical stage biotechnology company working to unleash the human immune system to prevent, treat or cure cancer, autoimmune conditions and infectious diseases. The company is currently conducting experimental medicine clinical trials using autologous T cells primed against cancer antigens and tethered to IL-15.
Omega Therapeutics, Inc. is a development-stage biotechnology company leveraging its proprietary epigenomic programming platform to biologically engineer a new class of programmable epigenetic medicines.
Cellarity is a therapeutics company that uses genomic technologies, data science, and AI to develop a new generation of therapies. Its platform digitizes the molecular information in cells to elucidate how they behave in health and disease. Cellarity is using its platform to design medicines targeting the full cellular and molecular complexity of the disease, enabling a quantum leap in the success rate and speed of drug discovery.
Tessera Therapeutics is an early-stage life sciences company pioneering Gene Writing, a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.
Valo Health, Inc (Valo) is a technology company focused on utilizing large scale data and AI-driven computation to discover and develop therapeutics. Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an end-to-end drug discovery and development platform with a unified architecture designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs, initially focused on cardiovascular metabolic renal, oncology, and neurodegenerative disease. Founded by Flagship Pioneering and headquartered in Boston, MA, Valo also has offices in Lexington, MA, and New York, NY. To learn more, visit valohealth.com.
Senda Biosciences is a developer of therapeutic applications intended for novel treatments of human disease. The company studies the molecular relationships between bacterial, botanical, and human cells as well as how they define health and disease, providing medical professionals with novel medications and delivery methods. Senda Biosciences was established in 2017 by David Kolesky, Ignacio Martinez, and John Casey in Cambridge, Massachusetts.
Generate Biomedicines is a biotechnological company focusing on creating breakthrough medicines. It pioneers in the field of Generative Biology, a revolutionary approach to drug development that allows them to program protein-based modalities for the first time. Generate Biomedicines has proved that its machine-learning platform can generate new biological molecules with therapeutic value, accelerating the drug discovery process.
Indigo Ag, Inc. operates an online platform that connects farmers with buyers and grain marketing advisors, facilitating the sale of grains. Founded in 2013 and headquartered in Boston, Massachusetts, the company aims to help farmers sustainably enhance their productivity and profitability through the use of beneficial plant microbes. By optimizing crop health and yield, Indigo's offerings enable farmers to implement regenerative agricultural practices while meeting specific buyer requirements for crop quality. The platform also supports growers with year-round partnerships and microbiome treatments tailored to improve farm management. Indigo operates in various locations worldwide, including Memphis, Research Triangle Park, Sydney, Buenos Aires, São Paulo, Basel, and Mumbai, reflecting its commitment to serving the agricultural community globally.
Omega Therapeutics, Inc. is a development-stage biotechnology company leveraging its proprietary epigenomic programming platform to biologically engineer a new class of programmable epigenetic medicines.
Sana Biotechnology focuses on creating and delivering engineered cells as medicine for patients. Recent scientific advances make it possible to reprogram cells in the body or replace damaged cells and tissues, creating a new class of medicines to treat a broad array of diseases. The company is a team of scientists, clinicians and biotechnology veterans focused on creating an enduring company that makes meaningful medicines and will change the approach in treating diseases.
Sigilon Therapeutics is to create immune-protected, engineered human cells that restore normal physiology in a wide range of diseases without generating fibrosis or immune rejection, liberating patients from challenges associated with serious chronic diseases. To address these therapy problems, Sigilon is developing its Shielded Living TherapeuticsTM platform. Sigilon is designing product candidates to provide a wide range of functions or therapeutic molecules that may be missing or deficient in the body, leveraging advances in cell differentiation and engineering, as well as cutting-edge innovations in its proprietary biocompatible materials—potentially resulting in functional cures for patients with a wide range of acute and chronic diseases.
Ohana Biosciences revolutionizes reproductive health to help people have babies, when and how they choose.
Ring Therapeutics is a multi-product platform company focused on discovering and developing Anellovector therapeutics to unlock the full potential of gene therapy. Founded by Flagship Pioneering, Ring is pioneering the first redosable and targetable gene therapy platform by harnessing the biology of the human commensal virome. The company is expanding the applications of gene therapy beyond gene replacement, enabling a much wider array of modalities and mechanisms to treat previously inaccessible diseases.
Invaio Sciences is a technology company that is dedicated to unlocking the potential of our planet’s interdependent natural systems to solve pressing agriculture, nutrition, and environmental challenges. Invaio Sciences is a flagship pioneering company startup in Cambridge. They are at the forefront of developing novel technologies based on groundbreaking science with an intent to positively impact their planet by enabling the application of breakthrough solutions in agriculture, human health, animal nutrition and animal health.
Cellarity is a therapeutics company that uses genomic technologies, data science, and AI to develop a new generation of therapies. Its platform digitizes the molecular information in cells to elucidate how they behave in health and disease. Cellarity is using its platform to design medicines targeting the full cellular and molecular complexity of the disease, enabling a quantum leap in the success rate and speed of drug discovery.
Cygnal Therapeutics is developing drugs to manipulate Exoneural Biology for the treatment of cancer, immunological diseases, and regenerative processes. Powered by a comprehensive, cutting-edge neurotechnology platform, They are discovering new dimensions of neural function. Cygnal was founded by Flagship Pioneering in the VentureLabs innovation foundry.
Inari Agriculture, Inc. is a biotechnology company that specializes in developing customized seeds through CRISPR gene editing technology, aimed at optimizing crop growth in diverse environmental conditions. Founded in 2016 and based in Cambridge, Massachusetts, Inari focuses on crops such as wheat, soybean, and corn, addressing significant agricultural challenges like climate change. The company employs advanced multiplex gene editing and predictive design to create efficient and sustainable plant breeding solutions, thereby reducing the time and cost associated with traditional breeding methods. Inari's approach aims to enhance agricultural productivity while respecting environmental sustainability, and it collaborates with a diverse team of scientists and partners globally to drive innovation in the agricultural sector.
Valo Health, Inc (Valo) is a technology company focused on utilizing large scale data and AI-driven computation to discover and develop therapeutics. Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an end-to-end drug discovery and development platform with a unified architecture designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs, initially focused on cardiovascular metabolic renal, oncology, and neurodegenerative disease. Founded by Flagship Pioneering and headquartered in Boston, MA, Valo also has offices in Lexington, MA, and New York, NY. To learn more, visit valohealth.com.
Sana Biotechnology focuses on creating and delivering engineered cells as medicine for patients. Recent scientific advances make it possible to reprogram cells in the body or replace damaged cells and tissues, creating a new class of medicines to treat a broad array of diseases. The company is a team of scientists, clinicians and biotechnology veterans focused on creating an enduring company that makes meaningful medicines and will change the approach in treating diseases.
Axcella is a clinical-stage biotechnology company that treats complex diseases using endogenous metabolic modulator (EMM) compositions. They combine biological pathways with developments in systems biology and machine learning. Their proprietary platform is clinically validated across several indication areas, with clinical-stage candidates in muscle, neurodegenerative, and liver conditions.
KSQ Therapeutics is pioneering High-Confidence Drug Development: a fundamentally new approach to R&D where the majority of the de-risking work is done prior to the generation of therapeutic drug candidates. Powered by our proprietary CRISPRomics™ drug discovery engine, their team has elucidated the function that each human gene plays in multiple diseases, providing a unique and more comprehensive understanding of disease biology. The quality of these insights enables their scientists to rapidly identify and validate high-confidence, patient-tailored, novel drug targets and then focus their collective efforts on the development of medicines with the greatest potential to impact the lives of patients. KSQ has initiated a pipeline of preclinical discovery programs and was founded in 2015.
Indigo Ag, Inc. operates an online platform that connects farmers with buyers and grain marketing advisors, facilitating the sale of grains. Founded in 2013 and headquartered in Boston, Massachusetts, the company aims to help farmers sustainably enhance their productivity and profitability through the use of beneficial plant microbes. By optimizing crop health and yield, Indigo's offerings enable farmers to implement regenerative agricultural practices while meeting specific buyer requirements for crop quality. The platform also supports growers with year-round partnerships and microbiome treatments tailored to improve farm management. Indigo operates in various locations worldwide, including Memphis, Research Triangle Park, Sydney, Buenos Aires, São Paulo, Basel, and Mumbai, reflecting its commitment to serving the agricultural community globally.
Kaleido Biosciences is a clinical-stage healthcare company with a differentiated, chemistry-driven approach to leveraging the potential of the microbiome organ to treat disease and improve human health. The Company has built a human-centric proprietary product platform to enable the rapid and cost-efficient discovery and development of novel Microbiome Metabolic Therapies (MMT™). MMTs are designed to modulate the metabolic output and profile of the microbiome by driving the function and distribution of the organ’s existing microbes. Kaleido is advancing a broad pipeline of MMT candidates with the potential to address a variety of diseases and conditions with significant unmet patient needs.
Foghorn Therapeutics is developing therapies based on a system that directs which genes our cells express, and when, where, and in what order.By manipulating this system with our unique Gene Traffic ControlTM platform, Foghorn will change how genes turn “on” and “off.” Unlike approaches that edit genes, this novel way of thinking will alter what our DNA has in store for us—and rewrite destiny for millions of people living with disease.With Gene Traffic ControlTM Foghorn is pioneering a new, major class of drug targets to develop unprecedented therapies for cancer and other serious diseases. We have already validated multiple targets, are in the process of developing drug candidates in multiple types of cancer and are beginning to explore other diseases.
Rubius Therapeutics is creating RCTs™ as a new class of medicines. Leading applications include programs in cancer, enzyme deficiency diseases and the induction of tolerance to treat autoimmune disease. The company was conceived and launched by Flagship VentureLabs®, the innovation foundry where a team of scientific entrepreneurs systematically evolve enterprising ideas based upon previously undiscovered areas of science into real-world inventions and ventures.
Inzen Therapeutics is a early-stage biotechnology company exploring cellular turnover as a surprising and important driver of disease.
TARIS Biomedical develops new therapies designed for the treatment of difficult-to-treat bladder diseases. The company's system is designed to continuously release drugs in the bladder over weeks to months and is deployed and retrieved using minimally-invasive, in-office procedures, enabling drug release to be tailored to match the needs of each disease.
Codiak is a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics, a new class of medicines with the potential to transform the treatment of a wide spectrum of diseases with high unmet medical need. By leveraging the biology of exosomes as natural intercellular transfer mechanisms, Codiak has developed its proprietary engEx Platform to expand upon the innate properties of exosomes to design, engineer and manufacture novel exosome therapeutic candidates. Codiak has utilized its engEx Platform to generate a deep pipeline of engineered exosomes aimed at treating a broad range of disease areas, spanning oncology, neuro-oncology, neurology, neuromuscular disease and infectious disease.
Repertoire Immune Medicines is a clinical stage biotechnology company working to unleash the human immune system to prevent, treat or cure cancer, autoimmune conditions and infectious diseases. The company is currently conducting experimental medicine clinical trials using autologous T cells primed against cancer antigens and tethered to IL-15.
Visterra, Inc. engages in pharmaceutical drug research and development of therapeutic and diagnostic products for infectious diseases. It also provides structure-based design of therapeutics and diagnostic platforms, based on an understanding of glycobiology and glycochemistry. The company was formerly known as Parasol Therapeutics, Inc. and changed its name in May 2010. Visterra, Inc. was founded in 2007 and is based in Cambridge, Massachusetts.
KSQ Therapeutics is pioneering High-Confidence Drug Development: a fundamentally new approach to R&D where the majority of the de-risking work is done prior to the generation of therapeutic drug candidates. Powered by our proprietary CRISPRomics™ drug discovery engine, their team has elucidated the function that each human gene plays in multiple diseases, providing a unique and more comprehensive understanding of disease biology. The quality of these insights enables their scientists to rapidly identify and validate high-confidence, patient-tailored, novel drug targets and then focus their collective efforts on the development of medicines with the greatest potential to impact the lives of patients. KSQ has initiated a pipeline of preclinical discovery programs and was founded in 2015.
Indigo Ag, Inc. operates an online platform that connects farmers with buyers and grain marketing advisors, facilitating the sale of grains. Founded in 2013 and headquartered in Boston, Massachusetts, the company aims to help farmers sustainably enhance their productivity and profitability through the use of beneficial plant microbes. By optimizing crop health and yield, Indigo's offerings enable farmers to implement regenerative agricultural practices while meeting specific buyer requirements for crop quality. The platform also supports growers with year-round partnerships and microbiome treatments tailored to improve farm management. Indigo operates in various locations worldwide, including Memphis, Research Triangle Park, Sydney, Buenos Aires, São Paulo, Basel, and Mumbai, reflecting its commitment to serving the agricultural community globally.
Kaleido Biosciences is a clinical-stage healthcare company with a differentiated, chemistry-driven approach to leveraging the potential of the microbiome organ to treat disease and improve human health. The Company has built a human-centric proprietary product platform to enable the rapid and cost-efficient discovery and development of novel Microbiome Metabolic Therapies (MMT™). MMTs are designed to modulate the metabolic output and profile of the microbiome by driving the function and distribution of the organ’s existing microbes. Kaleido is advancing a broad pipeline of MMT candidates with the potential to address a variety of diseases and conditions with significant unmet patient needs.
Omega Therapeutics, Inc. is a development-stage biotechnology company leveraging its proprietary epigenomic programming platform to biologically engineer a new class of programmable epigenetic medicines.
Evelo Biosciences is dedicated to improving the lives of patients globally through the development of a new modality of medicines – monoclonal microbials. Monoclonal microbials are orally delivered medicines that modulate systemic immunology and biology through direct interactions with human cells in the gut. These new medicines are broadly applicable across many diseases – including autoimmune, immunoinflammatory, metabolic, neurological, neuroinflammatory diseases, and cancer. Monoclonal microbials have the potential to fundamentally change traditional models of drug discovery and development. By finding and selecting naturally occurring monoclonal microbial with defined therapeutic effects, Evelo can improve the speed, cost, and success of drug discovery and development. Evelo’s platform enables pharmacological intervention at all stages of the disease with naturally occurring, safe, and effective monoclonal microbials. Evelo Biosciences was conceived and created within VentureLabs®, Flagship Pioneering’s institutional innovation foundry, and launched by Flagship in 2015.
Rubius Therapeutics is creating RCTs™ as a new class of medicines. Leading applications include programs in cancer, enzyme deficiency diseases and the induction of tolerance to treat autoimmune disease. The company was conceived and launched by Flagship VentureLabs®, the innovation foundry where a team of scientific entrepreneurs systematically evolve enterprising ideas based upon previously undiscovered areas of science into real-world inventions and ventures.
CIBO applies advanced technologies to deliver a deep understanding of agricultural systems to help mitigate climate change, advance food system resilience, and improve grower outcomes through driving the adoption of sustainable practices. CIBO is a 2021 Fast Company World Changing Ideas Awards finalist and was named 2021 AgTech Breakthrough “AI-based AgTech Company of the Year.”
Oasys (Osmotic Application Systems) is a privately held Boston, MA based company developing a suite of proprietary energy and resource recovery products to address the growing, global water crisis. Engineered Osmosisâ„¢ (EOâ„¢) is a platform for reducing cost in the production of clean water, power and energy through more efficient and sustainable utilization of resources.
Boragen develops synthetic chemistry platforms designed to produce next-generation fungicides. The platform supports sustainable farming methods by creating a compound that decreases the probability of fungicide resistance and reduces the amount of chemical applied while maintaining performance and efficacy. The company utilizes boron’s unique properties to design and develop novel solutions targeting needs in crop protection, animal health, and human health. Founded in 2015, Boragen is based in Durham, North Carolina.
Tarveda Therapeutics is a developer of miniature drug conjugates designed for the treatment of patients with a wide range of solid tumors. The company's HSP90 targeted drug conjugate platform with lead drug candidate PEN-866 selectively binds in tumors to the activated form of Heat Shock Protein 90 (HSP90) and releases its potent topoisomerase 1 inhibitor payload, SN38 and it also develops a miniature drug conjugate in clinical evaluation for the treatment of patients with somatostatin receptor 2 (SSTR2) expressing neuroendocrine, small cell lung and other solid tumors, enabling companies to extend the lives of patients with hard to treat cancers while minimizing potential toxicities.
Incredible Foods strives to develop unique, all-inclusive products that are delicious, fun to eat and enhance the lives of those who enjoy them. Through its perfectly free™ brand, the Company is committed to creating delicious "Big 8 Allergy-Friendly™" foods for everyone who desire a fuller, happier, healthier, free-from lifestyle. perfectly free™ contain only natural, premium ingredients that are non-GMO and free from the Big 8 food allergens: dairy, wheat, peanuts, tree nuts, eggs, soy, fish and shellfish. All products are prepared in a dedicated, free-from facility.
YourBio Health is developing novel products to optimize the interface of diagnostic medicine and the healthcare consumer by dramatically simplifying blood sampling and testing. By eliminating the barriers to the acquisition of critical diagnostic information, Seventh Sense is contributing to the future of informed, effective healthcare delivery and patient participation in their own well-being. The Seventh Sense On Vivo™ platform will enable diagnostic testing to be performed safely and painlessly by virtually anyone, anywhere. Their proprietary, single-step Touch Activated Phlebotomy™ (TAP™) technology can be combined with a variety of diagnostic assays for rapid results. TAP's revolutionary sampling capabilities may also integrate with analytical systems to vastly improve the patient and clinician experience.
Denali Therapeutics is a biotechnology company focused on the discovery and development of therapies for patients with neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, ALS and others. Denali was founded by scientists, industry experts and investors who share the vision that recent scientific insights into the genetic causes and biological processes underlying neurodegenerative disease, together with new translational medicine tools, offer an unprecedented opportunity to discover and develop effective medicines. Denali is rigorously pursuing a science-driven approach to translational medicine and clinical development.
Indigo Ag, Inc. operates an online platform that connects farmers with buyers and grain marketing advisors, facilitating the sale of grains. Founded in 2013 and headquartered in Boston, Massachusetts, the company aims to help farmers sustainably enhance their productivity and profitability through the use of beneficial plant microbes. By optimizing crop health and yield, Indigo's offerings enable farmers to implement regenerative agricultural practices while meeting specific buyer requirements for crop quality. The platform also supports growers with year-round partnerships and microbiome treatments tailored to improve farm management. Indigo operates in various locations worldwide, including Memphis, Research Triangle Park, Sydney, Buenos Aires, São Paulo, Basel, and Mumbai, reflecting its commitment to serving the agricultural community globally.
Private Equity Round in 2016
TransMedics provides technology and clinical service solutions, service for heart and lung transplant volume, clinical outcomes, and reduce learning curves.
Visterra, Inc. engages in pharmaceutical drug research and development of therapeutic and diagnostic products for infectious diseases. It also provides structure-based design of therapeutics and diagnostic platforms, based on an understanding of glycobiology and glycochemistry. The company was formerly known as Parasol Therapeutics, Inc. and changed its name in May 2010. Visterra, Inc. was founded in 2007 and is based in Cambridge, Massachusetts.
TransMedics provides technology and clinical service solutions, service for heart and lung transplant volume, clinical outcomes, and reduce learning curves.
Indigo Ag, Inc. operates an online platform that connects farmers with buyers and grain marketing advisors, facilitating the sale of grains. Founded in 2013 and headquartered in Boston, Massachusetts, the company aims to help farmers sustainably enhance their productivity and profitability through the use of beneficial plant microbes. By optimizing crop health and yield, Indigo's offerings enable farmers to implement regenerative agricultural practices while meeting specific buyer requirements for crop quality. The platform also supports growers with year-round partnerships and microbiome treatments tailored to improve farm management. Indigo operates in various locations worldwide, including Memphis, Research Triangle Park, Sydney, Buenos Aires, São Paulo, Basel, and Mumbai, reflecting its commitment to serving the agricultural community globally.
Codiak is a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics, a new class of medicines with the potential to transform the treatment of a wide spectrum of diseases with high unmet medical need. By leveraging the biology of exosomes as natural intercellular transfer mechanisms, Codiak has developed its proprietary engEx Platform to expand upon the innate properties of exosomes to design, engineer and manufacture novel exosome therapeutic candidates. Codiak has utilized its engEx Platform to generate a deep pipeline of engineered exosomes aimed at treating a broad range of disease areas, spanning oncology, neuro-oncology, neurology, neuromuscular disease and infectious disease.
Rubius Therapeutics is creating RCTs™ as a new class of medicines. Leading applications include programs in cancer, enzyme deficiency diseases and the induction of tolerance to treat autoimmune disease. The company was conceived and launched by Flagship VentureLabs®, the innovation foundry where a team of scientific entrepreneurs systematically evolve enterprising ideas based upon previously undiscovered areas of science into real-world inventions and ventures.
Codiak is a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics, a new class of medicines with the potential to transform the treatment of a wide spectrum of diseases with high unmet medical need. By leveraging the biology of exosomes as natural intercellular transfer mechanisms, Codiak has developed its proprietary engEx Platform to expand upon the innate properties of exosomes to design, engineer and manufacture novel exosome therapeutic candidates. Codiak has utilized its engEx Platform to generate a deep pipeline of engineered exosomes aimed at treating a broad range of disease areas, spanning oncology, neuro-oncology, neurology, neuromuscular disease and infectious disease.
Evelo Biosciences is dedicated to improving the lives of patients globally through the development of a new modality of medicines – monoclonal microbials. Monoclonal microbials are orally delivered medicines that modulate systemic immunology and biology through direct interactions with human cells in the gut. These new medicines are broadly applicable across many diseases – including autoimmune, immunoinflammatory, metabolic, neurological, neuroinflammatory diseases, and cancer. Monoclonal microbials have the potential to fundamentally change traditional models of drug discovery and development. By finding and selecting naturally occurring monoclonal microbial with defined therapeutic effects, Evelo can improve the speed, cost, and success of drug discovery and development. Evelo’s platform enables pharmacological intervention at all stages of the disease with naturally occurring, safe, and effective monoclonal microbials. Evelo Biosciences was conceived and created within VentureLabs®, Flagship Pioneering’s institutional innovation foundry, and launched by Flagship in 2015.
TARIS Biomedical develops new therapies designed for the treatment of difficult-to-treat bladder diseases. The company's system is designed to continuously release drugs in the bladder over weeks to months and is deployed and retrieved using minimally-invasive, in-office procedures, enabling drug release to be tailored to match the needs of each disease.
Editas Medicine is engaged in discovering and developing a novel class of genome editing therapeutics. The company has generated substantial patent filings and has access to intellectual property covering foundational genome editing technologies, as well as essential advancements and enablements that will uniquely allow the company to translate early findings into viable human therapeutic products. Editas Medicine's mission is to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level. It was founded in 2013 and is headquartered in Cambridge, Massachusetts, the United States with a growing site in Boulder, Colorado.
Axcella is a clinical-stage biotechnology company that treats complex diseases using endogenous metabolic modulator (EMM) compositions. They combine biological pathways with developments in systems biology and machine learning. Their proprietary platform is clinically validated across several indication areas, with clinical-stage candidates in muscle, neurodegenerative, and liver conditions.
Denali Therapeutics is a biotechnology company focused on the discovery and development of therapies for patients with neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, ALS and others. Denali was founded by scientists, industry experts and investors who share the vision that recent scientific insights into the genetic causes and biological processes underlying neurodegenerative disease, together with new translational medicine tools, offer an unprecedented opportunity to discover and develop effective medicines. Denali is rigorously pursuing a science-driven approach to translational medicine and clinical development.
Private Equity Round in 2015
Joule Unlimited, Inc. produces infrastructure-compatible fuels directly from sunlight and waste carbon dioxide. It captures sunlight to produce energy in liquid forms, such as diesel and ethanol, as well as uses waste carbon dioxide as a sole feedstock to produce liquid fuels. Joule Unlimited, Inc. was formerly known as Joule Biotechnologies, Inc. and changed its name to Joule Unlimited, Inc. in 2010. The company was founded in 2007 and is headquartered in Cambridge, Massachusetts with an additional office in Los Angeles, California.
Red Rock Biofuels (RRB) develops processing plants to convert woody biomass into renewable, drop-in diesel and jet fuels. Each refinery is designed to utilize 175,000 dry tons of woody biomass feedstock to produce 16 million gallons per year of finished products. RRB’s technology platform converts woody biomass to jet, diesel, and naphtha fuels. The process begins with the gasification of woody biomass to produce synthesis gas. This synthesis gas is cleaned and sent to a Fischer-Tropsch unit where it is converted to liquid hydrocarbons. Hydroprocessing refines the liquid hydrocarbons to produce jet, diesel, and naptha fuels. Red Rock Biofuels was founded by Jeff Manternach and Terry Kulesa and is based in Colorado, United States.
Tarveda Therapeutics is a developer of miniature drug conjugates designed for the treatment of patients with a wide range of solid tumors. The company's HSP90 targeted drug conjugate platform with lead drug candidate PEN-866 selectively binds in tumors to the activated form of Heat Shock Protein 90 (HSP90) and releases its potent topoisomerase 1 inhibitor payload, SN38 and it also develops a miniature drug conjugate in clinical evaluation for the treatment of patients with somatostatin receptor 2 (SSTR2) expressing neuroendocrine, small cell lung and other solid tumors, enabling companies to extend the lives of patients with hard to treat cancers while minimizing potential toxicities.
EcoSense Lighting is a team of LED lighting pioneers with over 100 years of experience and a genuine passion for delivering advanced solid-state lighting solutions. EcoSense delivers a broad line of high-quality, cutting-edge LED lighting solutions for architectural and commercial applications. EcoSense has a compelling technology portfolio including the new industry-leading breakthrough dimming technology. EcoSense has offices in the United States, the United Kingdom, and Hong Kong with headquarters in Los Angeles.
Seres Therapeutics is a clinical-stage biotherapeutic company that develops ecobiotic therapeutic products. They engaged in developing biological drugs which are referred to as ecobiotic microbiome therapeutics. The company is a group of experts in microbiome research and drug development. Its executive team, board of directors, and scientific advisory board have a wealth of experience in the development, regulatory approval, and profitable commercialization of a wide range of therapeutic products.
Indigo Ag, Inc. operates an online platform that connects farmers with buyers and grain marketing advisors, facilitating the sale of grains. Founded in 2013 and headquartered in Boston, Massachusetts, the company aims to help farmers sustainably enhance their productivity and profitability through the use of beneficial plant microbes. By optimizing crop health and yield, Indigo's offerings enable farmers to implement regenerative agricultural practices while meeting specific buyer requirements for crop quality. The platform also supports growers with year-round partnerships and microbiome treatments tailored to improve farm management. Indigo operates in various locations worldwide, including Memphis, Research Triangle Park, Sydney, Buenos Aires, São Paulo, Basel, and Mumbai, reflecting its commitment to serving the agricultural community globally.
Syros Pharmaceuticals is a life sciences company that is focused on treating disease by mapping gene regulatory circuits and modulating the factors that regulate gene expression. Syros has pioneered world-leading gene control research and drug discovery capabilities with a proven ability to integrate disease biology and genomic data--a proficiency that is not well represented in pharmaceutical R&D. Central to the Syros approach is a proprietary platform of carefully integrated assay technologies, bioinformatics, and biologic insights developed by members of Syros' senior leadership. While this scientific approach has applications in many therapeutic areas, Syros has demonstrated success initially in oncology, where it may help address numerous unmet medical needs.
Private Equity Round in 2014
Selecta Biosciences is a biopharmaceutical company developing the first generation of nanoparticle immunomodulatory drugs for the treatment and prevention of human diseases. Their proprietary product platform technology combines recent advances in immunobiology with cutting-edge nanotechnology to develop targeted immunomodulatory nanoparticles. It was founded in 2008 and is headquartered in Watertown, Massachusetts.
Visterra, Inc. engages in pharmaceutical drug research and development of therapeutic and diagnostic products for infectious diseases. It also provides structure-based design of therapeutics and diagnostic platforms, based on an understanding of glycobiology and glycochemistry. The company was formerly known as Parasol Therapeutics, Inc. and changed its name in May 2010. Visterra, Inc. was founded in 2007 and is based in Cambridge, Massachusetts.
Black Duck secures and manages open source software worldwide, eliminating open source security vulnerabilities and license compliance pain. With the rapid, widespread adoption of open-source software, Black Duck is a key component of Synopsys’ Software Integrity Platform, the most comprehensive solution for integrating security into the SDLC and software supply chain. Black Duck was established in 2002 and is based in Burlington, Massachusetts, United States.
YourBio Health is developing novel products to optimize the interface of diagnostic medicine and the healthcare consumer by dramatically simplifying blood sampling and testing. By eliminating the barriers to the acquisition of critical diagnostic information, Seventh Sense is contributing to the future of informed, effective healthcare delivery and patient participation in their own well-being. The Seventh Sense On Vivo™ platform will enable diagnostic testing to be performed safely and painlessly by virtually anyone, anywhere. Their proprietary, single-step Touch Activated Phlebotomy™ (TAP™) technology can be combined with a variety of diagnostic assays for rapid results. TAP's revolutionary sampling capabilities may also integrate with analytical systems to vastly improve the patient and clinician experience.
Seres Therapeutics is a clinical-stage biotherapeutic company that develops ecobiotic therapeutic products. They engaged in developing biological drugs which are referred to as ecobiotic microbiome therapeutics. The company is a group of experts in microbiome research and drug development. Its executive team, board of directors, and scientific advisory board have a wealth of experience in the development, regulatory approval, and profitable commercialization of a wide range of therapeutic products.
Tarveda Therapeutics is a developer of miniature drug conjugates designed for the treatment of patients with a wide range of solid tumors. The company's HSP90 targeted drug conjugate platform with lead drug candidate PEN-866 selectively binds in tumors to the activated form of Heat Shock Protein 90 (HSP90) and releases its potent topoisomerase 1 inhibitor payload, SN38 and it also develops a miniature drug conjugate in clinical evaluation for the treatment of patients with somatostatin receptor 2 (SSTR2) expressing neuroendocrine, small cell lung and other solid tumors, enabling companies to extend the lives of patients with hard to treat cancers while minimizing potential toxicities.
Axcella is a clinical-stage biotechnology company that treats complex diseases using endogenous metabolic modulator (EMM) compositions. They combine biological pathways with developments in systems biology and machine learning. Their proprietary platform is clinically validated across several indication areas, with clinical-stage candidates in muscle, neurodegenerative, and liver conditions.
Visterra, Inc. engages in pharmaceutical drug research and development of therapeutic and diagnostic products for infectious diseases. It also provides structure-based design of therapeutics and diagnostic platforms, based on an understanding of glycobiology and glycochemistry. The company was formerly known as Parasol Therapeutics, Inc. and changed its name in May 2010. Visterra, Inc. was founded in 2007 and is based in Cambridge, Massachusetts.
Editas Medicine is engaged in discovering and developing a novel class of genome editing therapeutics. The company has generated substantial patent filings and has access to intellectual property covering foundational genome editing technologies, as well as essential advancements and enablements that will uniquely allow the company to translate early findings into viable human therapeutic products. Editas Medicine's mission is to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level. It was founded in 2013 and is headquartered in Cambridge, Massachusetts, the United States with a growing site in Boulder, Colorado.
Moderna Therapeutics is a biotechnology company that develops messenger RNA therapeutics. Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. It provides in vivo drug modality that produces human proteins or antibodies inside patient cells. Moderna Therapeutics also develops various patent applications with various claims ranging from novel nucleotide chemistries to specific drug compositions. It focuses on disease areas, such as inherited genetic disorders, hemophilia, and blood factors, and oncology. Moderna Therapeutics in 2010 and is headquartered in Cambridge in Massachusetts. It has strategic option agreements with AstraZeneca and Alexion Pharmaceuticals and strategic collaborations with Karolinska Institutet, Institut Pasteur, Karolinska University Hospital, and Merck.
EcoSense Lighting is a team of LED lighting pioneers with over 100 years of experience and a genuine passion for delivering advanced solid-state lighting solutions. EcoSense delivers a broad line of high-quality, cutting-edge LED lighting solutions for architectural and commercial applications. EcoSense has a compelling technology portfolio including the new industry-leading breakthrough dimming technology. EcoSense has offices in the United States, the United Kingdom, and Hong Kong with headquarters in Los Angeles.
Axcella is a clinical-stage biotechnology company that treats complex diseases using endogenous metabolic modulator (EMM) compositions. They combine biological pathways with developments in systems biology and machine learning. Their proprietary platform is clinically validated across several indication areas, with clinical-stage candidates in muscle, neurodegenerative, and liver conditions.
Syros Pharmaceuticals is a life sciences company that is focused on treating disease by mapping gene regulatory circuits and modulating the factors that regulate gene expression. Syros has pioneered world-leading gene control research and drug discovery capabilities with a proven ability to integrate disease biology and genomic data--a proficiency that is not well represented in pharmaceutical R&D. Central to the Syros approach is a proprietary platform of carefully integrated assay technologies, bioinformatics, and biologic insights developed by members of Syros' senior leadership. While this scientific approach has applications in many therapeutic areas, Syros has demonstrated success initially in oncology, where it may help address numerous unmet medical needs.
T2 Biosystems is a private company developing a next-generation medical diagnostic platform that enables rapid and accurate diagnostic tests of all types on a single, easy-to-use instrument. The company's proprietary technology combines nanotechnology and miniaturized magnetic resonance (MR) technology and eliminates the need for costly and time-consuming sample preparation.
Receptos is a privately-held drug discovery and development company which utilizes pioneering G protein-coupled receptor (GPCR) technology to facilitate information-driven drug design for developing best- and first-in-class drugs.
TARIS Biomedical develops new therapies designed for the treatment of difficult-to-treat bladder diseases. The company's system is designed to continuously release drugs in the bladder over weeks to months and is deployed and retrieved using minimally-invasive, in-office procedures, enabling drug release to be tailored to match the needs of each disease.
Avedro is a privately held medical device and pharmaceutical company advancing the science and technology of corneal cross-linking. Avedro recently completed its US‐based, multi-centered, Phase III studies of corneal cross-linking for the treatment of progressive keratoconus and corneal ectasia following refractive surgery. Outside the United States, Avedro has commercialized both VibeX and its KXL System for performing Lasik Xtra and accelerated cross-linking. Additionally, Avedro is developing the science of Thermo‐biomechanics for therapeutic medical applications. The Keraflex® refractive correction procedure is the first technology developed from the Thermo‐biomechanics platform and is a non‐invasive, incision‐less ophthalmic procedure for flattening the cornea without the removal of tissue. Keraflex offers the unique ability to induce refractive change without weakening the cornea’s biomechanical integrity, as happens with Lasik and other refractive correction procedures. Keraflex is commercially available outside of the United States.
Moderna Therapeutics is a biotechnology company that develops messenger RNA therapeutics. Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. It provides in vivo drug modality that produces human proteins or antibodies inside patient cells. Moderna Therapeutics also develops various patent applications with various claims ranging from novel nucleotide chemistries to specific drug compositions. It focuses on disease areas, such as inherited genetic disorders, hemophilia, and blood factors, and oncology. Moderna Therapeutics in 2010 and is headquartered in Cambridge in Massachusetts. It has strategic option agreements with AstraZeneca and Alexion Pharmaceuticals and strategic collaborations with Karolinska Institutet, Institut Pasteur, Karolinska University Hospital, and Merck.
Seres Therapeutics is a clinical-stage biotherapeutic company that develops ecobiotic therapeutic products. They engaged in developing biological drugs which are referred to as ecobiotic microbiome therapeutics. The company is a group of experts in microbiome research and drug development. Its executive team, board of directors, and scientific advisory board have a wealth of experience in the development, regulatory approval, and profitable commercialization of a wide range of therapeutic products.
TransMedics provides technology and clinical service solutions, service for heart and lung transplant volume, clinical outcomes, and reduce learning curves.
Quanterix Corporation is developing a novel platform for single-molecule analysis that will bring an unprecedented level of sensitivity, precision, and assay robustness to clinical diagnostics, drug development, and life science research. Their unique approach permits rapid quantification and analysis of individual proteins and small molecules within complex biological samples, enabling us to address a variety of unmet medical needs. The company’s ultra-sensitive detection solution, Simoa, has the potential to change the way in which healthcare is provided today by giving researchers the ability to closely examine the role of biomarkers in the continuum of health to disease. Quanterix’s technology is designed to enable much earlier disease detection, better prognosis, and precise treatment methods to improve the quality of life and longevity of the population for generations to come.
Tangent Medical Technologies, a development stage medical device company, was founded in Ann Arbor in 2009 based on technology exclusively licensed from the University of Michigan's Medical Innovation Center. The Company's mission is to improve infusion therapy for patients and healthcare workers with its proprietary, intravenous catheters and associated products. Tangent is led by an experienced, successful management team and the original inventors of the technology. The Company expects to begin generating commercial revenues from its lead product, the NovaCath⢠Closed IV Catheter System, in 2012.
Visterra, Inc. engages in pharmaceutical drug research and development of therapeutic and diagnostic products for infectious diseases. It also provides structure-based design of therapeutics and diagnostic platforms, based on an understanding of glycobiology and glycochemistry. The company was formerly known as Parasol Therapeutics, Inc. and changed its name in May 2010. Visterra, Inc. was founded in 2007 and is based in Cambridge, Massachusetts.