Red Cedar Ventures is a venture capital firm founded in 2014 and headquartered in East Lansing, Michigan. It makes early‑stage investments in high‑tech startups commercializing intellectual property created at Michigan State University, supporting the commercialization of MSU research through its connection to the MSU Research Foundation as a wholly‑owned subsidiary. The firm focuses on Michigan-based technology ventures, helping entrepreneurs bring university-origin innovations to market.

Biosciences Research and Commercialization Center is the venture capital investment arm of Western Michigan University, established in 2003 and based in Kalamazoo. It funds early-stage life sciences and medical device ventures in Michigan focusing on commercialization, with emphasis on startups that have a substantial Michigan presence and links to Southwest Michigan. The center leverages Kalamazoo's scientific talent and pharmaceutical commercialization heritage to support entrepreneurs, scientists, university technology transfer offices and corporate clients as they advance products in pharmaceuticals, medical devices and diagnostics. It provides startup and gap funding to promising ventures entering commercialization, typically investing between 25,000 and 250,000 per deal.

Michigan Rise is a venture capital firm headquartered in East Lansing, Michigan. It is a wholly-owned subsidiary of the Michigan State University Foundation and is administered by the Michigan State University Research Foundation. The firm focuses on investing in Michigan technology startups, with emphasis on advanced automotive and mobility, advanced manufacturing and materials, agricultural processing technology, alternative energy, homeland security and defense technology, information technology, life sciences, therapeutics, and medical devices. Through its programs, Michigan Rise provides capital, coaching, and assistance with grant funding to help entrepreneurs commercialize technologies and promote economic development in Michigan.

eLab Ventures is a venture capital firm founded in 2012 with offices in Ann Arbor, Michigan and California. It backs early-stage technology startups across artificial intelligence, big data, IoT, security, and biotechnology, seeking disruptive ideas, strong teams, and capital-efficient business models. The firm aims to connect entrepreneurs to capital and expertise, helping them access markets outside Silicon Valley by leveraging Midwest innovation and Silicon Valley networks for customers, partnerships, and growth.

Tappan Hill Ventures is a venture capital firm founded in 2014 and based in Ann Arbor, Michigan, pursuing seed, early-stage and rare later-stage investments with a focus on software, network connectivity, and the Internet of Things.

Beringea is an international venture capital and private equity firm founded in 1988 and headquartered in Michigan, with offices in the United States and the United Kingdom. It invests in growth-stage companies across the United States and the United Kingdom, providing equity and debt capital and hands-on support to management teams. The firm has a portfolio spanning sectors such as media, health care and life sciences, Internet technologies, advanced manufacturing, clean tech and consumer goods, and leverages its experience to help companies develop strategy, evaluate growth opportunities, and scale operations.

Wakestream Ventures is a Grand Rapids, Michigan-based venture capital firm that funds early-stage technology companies, with a focus on the convergence of hardware and software and internet-enabled physical products such as IoT devices. It invests in seed and early-stage ventures in the United States, particularly those leveraging hardware design, industrial design, and manufacturing. Typical initial investments range in the low hundreds of thousands, with follow-ons up to about $1.5 million cumulatively.

Service Provider Capital is a Colorado-based venture capital firm founded in 2014 that funds seed-stage technology companies across domains such as artificial intelligence, machine learning, blockchain, cybersecurity, fintech, e-commerce, education technology, hardware, robotics, information technology, health tech, and cannabis. The firm also co-invests in Series A rounds led by institutional venture funds, providing capital and guidance to startups in the United States, including the Midwest and Southeast regions.

Arboretum Ventures is a Michigan-based venture capital firm founded in 2002 and headquartered in Ann Arbor. It invests in healthcare companies across the United States, ranging from seed to growth stages, with a focus on services, medical devices, diagnostics, healthcare information technology, therapeutics, technology-enabled healthcare services, and life science tools. The firm typically targets equity investments of five to fifteen million dollars and concentrates its activity in the Midwest, particularly Michigan.

Grand Angels is an angel investment group based in Grand Rapids, Michigan, founded in 2004. It operates as a regional investor serving Michigan’s West region, funding early-stage companies across a broad range of sectors and counties, with a focus on Kent, Ottawa and Muskegon. The group typically invests from 250,000 to 1,000,000 in seed and early rounds and complements capital with mentoring and a patient exit approach. In addition to investments, Grand Angels provides financial consultancy services to startups and entrepreneurs.

Ludlow Ventures is a Michigan-based venture capital firm founded in 2009 that focuses on seed and early-stage technology companies in the United States, with offices in Detroit and Southfield. The firm backs software and information technology startups and emphasizes a pragmatic, founder-friendly approach, offering hands-on support, product testing, and access to its network to help portfolio companies grow. It advocates a low-ego, straightforward culture and aims to deliver practical, no-nonsense value rather than traditional venture capital puffery.

The Zell Lurie Commercialization Fund (ZLCF) is a pre-seed investment fund focused on identifying and promoting the commercialization of innovative ideas originating from the South-East Michigan region. By providing financial support and resources, the fund aims to facilitate the development of early-stage ventures, helping entrepreneurs transform their concepts into viable businesses. ZLCF plays a crucial role in fostering local economic growth and nurturing the entrepreneurial ecosystem in the area.

Huron River Ventures is a Michigan-based venture capital firm focused on early-stage investments in energy, agriculture, manufacturing, and technology sectors. Based in Ann Arbor, the firm backs startups across cloud and mobile computing, the Internet of Things, artificial intelligence, augmented and virtual reality, automation, clean tech, sustainable energy technologies, climate-related innovation, digital transformation, and robotics.

BioStar Capital is a Michigan-based venture capital firm focused on transformative medical technologies, with a primary emphasis on cardiology and healthcare devices. Founded in 2003 by Louis A. Cannon, the firm combines clinicians, executives, and thought leaders to guide investments and manages several venture funds targeting early and growth-stage opportunities in healthcare, biotech, and life sciences across the United States, Europe, and Israel.

Venture Investors is a Wisconsin-based venture capital firm that concentrates on seed and early-stage investments in healthcare, life sciences, diagnostics, therapeutics, medical devices, digital health, and related technology sectors. Headquartered in Madison with offices in Ann Arbor and Milwaukee, it seeks opportunities linked to university technology transfer and licenses from research institutions, particularly in the Midwest. The firm typically makes seed investments ranging from approximately 0.25 million to 2.5 million and can lead or co-invest, often investing in preferred stock and/or debt with warrant coverage. It targets companies with meaningful market potential and a constructive path to exit within five to seven years, through an initial public offering or strategic sale. While rooted in the Midwest research ecosystem, Venture Investors also evaluates nationwide opportunities aligned with its healthcare and technology portfolio.

Grand Ventures is a Michigan-based venture capital firm founded in 2017 that focuses on seed and early-stage technology startups in the United States and Canada, with a particular emphasis on the Midwest and Great Lakes region. The firm backs B2B software and technology companies across sectors such as automotive and energy, agriculture and manufacturing, fintech, supply chain and logistics, digital health, and developer tools. Beyond capital, Grand Ventures provides strategic support through its advisory network to help entrepreneurs refine strategy, develop talent, and pursue successful exits.

Blue Water Angels is a network of more than 30 high-net-worth individuals and select organizations investing capital in promising companies. While return on investment is their primary goal, they also value supporting the entrepreneurial community for the economic benefit of the mid-Michigan region and the state. In its first year, the group received funding requests from over 100 companies, reviewed nearly 40 in detail, heard presentations from about a dozen, and closed its first investment in a mid-Michigan-based advanced materials company. Available capital for annual investments exceeds $1.4 million and is expected to grow.

Northern Michigan Angels is an angel investor group based in Traverse City, Michigan. Founded in 2012, it consists of local volunteers who invest in Michigan-based businesses to promote private sector economic development.

Mercury Fund is a Houston-based venture capital firm that backs early-stage technology companies across the United States, with additional activity in Ann Arbor. It concentrates on software, SaaS, cloud, data, and artificial intelligence, and emphasizes an operationally oriented approach to accelerate growth. Mercury Fund partners with both first-time entrepreneurs and experienced founders, offering strategic guidance and access to a broad growth-partner network to help startups scale, particularly in Middle America and other midcontinent markets. The firm manages multiple early-stage funds and maintains a focus on technology-driven businesses.

North Coast Technology Investors is a Michigan-based venture capital firm founded in 1998 with offices in Ann Arbor and Midland. It concentrates on early-stage technology companies in the United States, with emphasis on healthcare, software, and communications technology. The firm often acts as lead or sole investor and co-invests with other venture capital firms and corporate partners to support portfolio companies through multiple funding stages.

Charter Capital Partners is a Grand Rapids, Michigan-based investment bank and advisory firm serving the lower middle market. The firm offers buy-side and sell-side M&A advisory, capital raises, financial advisory, succession planning, and business valuation services, helping business owners and investors navigate transactions and strategic planning. It serves industries including distribution, furniture, food and beverage, metals manufacturing, industrial services, and technology and digital services.

Lux Capital is a venture capital firm based in New York City and Silicon Valley that funds seed- and early-stage technology and science startups. It concentrates on deep tech across the physical and life sciences, investing in biochemistry, material science, electronics, infrastructure, aerospace, satellites, drones, and space technologies, as well as software, machine learning, and artificial intelligence, genomics and synthetic biology. The firm takes an active role in helping entrepreneurs build high-growth companies and has a track record of launching more than 20 portfolio companies. With a technically engaged approach, Lux supports portfolio progress by leveraging deep domain insight and industry connections to drive leadership and scale.

Based in Ann Arbor, Michigan, Plymouth Growth is a venture capital and growth-investing firm that backs growth-stage technology companies, with a focus on B2B software and technology-enabled services in the United States and Canada, particularly the Midwest and mid-continent region. The firm targets businesses with proven models and strong teams, generally in the software, business services, and related sectors, and aims to partner with entrepreneurs to drive scalable growth. Leveraging operators' and advisors' experience, Plymouth Growth emphasizes a people-centric approach and hands-on support to help portfolio companies scale.

Annox Capital is a venture capital and private equity firm founded in 2013 and based in Birmingham, Michigan. It provides growth capital for startups and late-stage companies, with a focus on manufacturing, logistics, banking, healthcare, and real estate. The firm seeks investments in enterprises that employ disruptive technology or online strategies to improve business processes or human experiences, typically pursuing deals ranging from $100,000 to $30 million.

Fontinalis Partners is a Detroit- and Boston-based venture capital and private equity firm focused on next-generation mobility and related technology sectors. The firm invests across the mobility ecosystem, including connected vehicles, data and analytics, intelligent infrastructure, location-based services, mobility transactions, and new mobility models such as car sharing and ride sharing, as well as software and cloud-based services. It operates on a stage-agnostic basis, backing early to growth-stage companies across the United States, and aims to leverage management experience, strategic relationships, and transportation innovation expertise to scale portfolio companies. The firm often takes board seats and maintains offices in Detroit and Boston; it is not affiliated with Ford Motor Company and was founded in 2009.

Renaissance Venture Capital Management is a venture capital firm based in Ann Arbor, Michigan. It engages in direct investments across early, middle, and late stages and also manages fund-of-funds strategies, investing in venture capital funds across the United States with a focus on Michigan. The firm seeks co-investment opportunities in emerging Michigan companies and supports the regional startup ecosystem by connecting Michigan-based startups with national capital networks. Founded in 2008, it operates from Michigan and aims to foster economic growth through venture investments, typically reserving a range of between $0.5 million and $1 million per portfolio company in its direct investments.

RPM Ventures is a Michigan-based venture capital firm founded in 2000 and headquartered in Ann Arbor. It specializes in seed and early-stage investments across the United States, with an emphasis on technology-enabled sectors such as software, enterprise solutions, marketplaces, mobility and automotive, financial services, insurance, and real estate. The firm often backs business-to-business and software-driven ventures, including university spinouts, and has targeted opportunities tied to the Midwest manufacturing base. Known as a high-tech and information-technology investor, RPM Ventures has supported FinTech, InsurTech, Real Estate Tech, and related markets. It operates as an investment adviser and manages multiple early-stage funds to back scalable startups with strong technology and growth potential.

BELLE Michigan is a venture capital firm based in Michigan that focuses on early-stage investments in women-led companies across Michigan, the Midwest, and beyond. It provides human and financial capital to support capital-efficient, scalable ventures with unique products or services addressing urgent market needs. The organization emphasizes leadership and operational expertise, offering its experience to portfolio companies and to high net worth investors new to early-stage investing. Target sectors include technology-enabled services, life sciences and medical devices, mobile and internet, advanced manufacturing, and CleanTech. BELLE Michigan seeks teams with strong domain expertise and proven commercialization and entrepreneurial track records, and favors companies that have female leadership or commit to increasing female representation in executive and board roles. By aligning capital with strategic guidance, it aims to help high-growth companies scale while promoting diversity and inclusion.

Founded in 2019, Narrow Gauge Ventures is a venture capital firm based in Ann Arbor, Michigan. It makes minority investments across seed, early-stage, and later-stage rounds and focuses on healthcare-related sectors, including devices, supplies, services, and technology systems, as well as health tech, lifestyle, and wellness, in the United States.

Assembly Ventures is a Detroit, Michigan-based venture capital firm founded in 2020 that invests in mobility companies across digital and physical mobility, goods, data, and energy. The firm supports entrepreneurs in the mobility ecosystem through early-stage investments and strategic guidance, aiming to accelerate innovations that move people and goods across the Western world.

General Catalyst is a venture capital firm founded in 2000 that provides early-stage and growth equity investments in technology companies. It supports portfolio companies with momentum and mentorship to accelerate growth toward long-term success and typically engages across seed to growth stages, potentially taking minority or majority stakes. The firm targets a broad range of sectors enabled by software and technology, including consumer, enterprise, fintech, crypto, healthcare IT, and related areas, and maintains a multi-region presence with offices in North America and Europe to back companies as they scale globally.

Woodward Angels is an early-stage venture capital provider focused on tech startups in and around Detroit. It offers founder-friendly capital for pre-seed and seed-stage companies and complements funding with active hands-on support to help these startups grow and succeed.

MadDog Ventures is the corporate venture capital arm of MadDog Technology, focused on investing in companies that develop and market cloud-based business applications and software-enabled business models. Based in Birmingham, Michigan, the firm seeks ventures that disrupt existing industry models and monetize underutilized information. It provides capital and operating expertise beyond traditional venture capital support, offering direct help with application development, sales, finance, marketing, and administration to help portfolio companies grow.

Resonant Venture Partners is a venture capital firm based in Ann Arbor, Michigan, founded in 2010. It concentrates on seed and early-stage technology investments across the United States, with emphasis on cloud infrastructure, software and services, security, and the Internet of Things, including industrial IoT. The firm supports portfolio companies through early challenges in product, market, and operations as they scale.

Level Eight Ventures is a venture capital firm founded in 2018 and based in Ann Arbor, Michigan. It invests in companies operating across artificial intelligence, clean energy, mobility, healthcare, materials, chemicals, sensors, inspection, resources and environment sectors in North America and Europe, supporting ventures that apply enabling technologies such as biochemistry, materials science, robotics and AI to deliver cleaner, smarter and more sustainable solutions.

BELLE Capital is an early-stage investment group based in Douglas, Michigan. It makes seed and early-stage investments across the United States in digital/mobile and internet-enabled products and services, life sciences, healthcare, medical devices, health technology, digital health, cleantech, and information technology.

Prelude Ventures is a San Francisco-based venture capital firm founded in 2013 that backs early-stage startups with the potential to mitigate climate change. It focuses on investments across sectors including advanced energy, food and agriculture, transportation and logistics, advanced materials and manufacturing, and computing, supporting the development of category-defining businesses in these areas.

EDF Ventures is a Michigan-based venture capital firm, founded in 1987 and headquartered in Ann Arbor. The firm focuses on early-stage and growth investments in healthcare technologies, pharmaceuticals, medical devices, diagnostics, and information technology, including mobility, security, data management, and IP-based communications and networks. It prefers opportunities originating in the Midwest and Great Lakes region, with an interest in technologies developed at research universities, and pursues co-investments with venture partners nationwide. Typical initial investments range from $0.5 million to $1.5 million, with follow-on financings possible up to several million dollars. The firm is a licensed Small Business Investment Company. Beyond funding, EDF leverages its network to help portfolio companies build management teams, forge strategic partnerships, provide industry and functional expertise, and secure additional funding, guiding young companies through startup and high-growth phases toward profitability.

Ardesta is a private equity and venture capital firm founded in 1999 and based in Ann Arbor, Michigan, with an additional office in Hinsdale, Illinois. It invests in startup or seed, early stage, mid venture and late venture, as well as bridge and mezzanine financing, and seeks to invest in middle market companies. Its technology focus includes micro- and nanotechnology, communications, energy, environmental safety and security, and medical diagnostics and treatment.

Banana Capital is a venture capital firm based in Ann Arbor, Michigan, founded in 2021. It focuses on early-stage investments in startups, providing capital to help companies grow.

CourtsideVC is a New York-based private equity firm, founded in 2015, that specializes in seed and Series B investments in sports and technology-related industries across the United States.

Arbor Partners is a venture capital firm based in Ann Arbor, Michigan, that invests in information technology, next-generation enterprise software, semiconductors, advanced materials, and SaaS. The firm focuses on Midwest-based companies and may co-invest in other regions, supporting growth in software, hardware, and related technologies in the TMT sector.

Capital Midwest Fund is a venture capital firm based in Mequon, Wisconsin, that backs early-stage companies in the Midwest across sectors such as advanced manufacturing, life sciences, healthcare, B2B and business services, software and SaaS, information technology and IoT, and energy. The firm concentrates on Midwest investments, with Wisconsin as a primary focus, and targets initial investments typically in the low to mid single-digit millions per company. It also pursues ESG and diversity-inclusion related investments as part of its strategy.

Breakthrough Energy Ventures is an investor-led venture capital firm based in Kirkland, Washington, providing patient capital to climate and energy technology companies across seed, early, and later stages. It concentrates on environmental services, climate change, climate technology, and cleantech, investing minority stakes to back technologies that deliver reliable, affordable power while reducing emissions and advancing zero-emission energy solutions.

MK Capital is a United States-based venture capital and private equity firm founded in 2003. It concentrates on early and growth-stage technology companies, focusing on software and other technology-enabled sectors and primarily targets opportunities in the U.S. market. The firm provides strategic capital, deep operating expertise, and hands-on collaboration, including active board participation to help portfolio companies scale. MK Capital operates from multiple offices in the Chicago area and on the West Coast, including Northbrook, Deerfield, Ann Arbor, and Santa Monica, reflecting a broad regional footprint. By partnering with management teams on strategy, operations, and technology, the firm aims to accelerate growth for disruptive B2B software and related technology businesses.

TGap Ventures is a Kalamazoo, Michigan-based venture capital firm founded in 2002 that concentrates on early-stage investments across software, life sciences, medical devices, healthcare services, manufacturing, plastics, data and communications technologies, internet infrastructure, and related industries. The firm focuses on opportunities in the Midwest and across the United States, typically backing early rounds and often taking a board seat, with a preference for equity instruments such as preferred stock. It aims for exits of $50 million plus and typically holds investments for about five to seven years.

Camelot Venture Group is a private investment firm that pursues growth and expansion opportunities in direct-to-consumer, online, catalog and retail businesses, as well as technology-enabled companies across e-commerce, health and fitness, technology, healthcare, financial services and sports management. Founded in 2008, the firm combines hands-on operating support with marketing and operational expertise to help portfolio companies achieve scalable growth.

Entrepreneur Ventures is the corporate venture arm of Entrepreneur Media, founded in 2023 and based in Los Angeles. It invests across life sciences, consumer, enterprise, crypto, climate, and frontier technology, supporting startups from Day 1. Backed by Entrepreneur Media as a General Partner, it provides operating partners who assist with finance, operations, strategy, equity, talent, and engineering, and it helps startups access Entrepreneur Media's audience to accelerate traction. The firm maintains offices in Los Angeles, New York, Michigan, and Toronto and has a growing portfolio of companies with plans to invest broadly from its initial fund.

RTA Ventures, founded in 2011, is a venture capital firm with a focus on early-stage investments in online businesses, particularly in the healthcare sector. The firm is headquartered in New Hudson, Michigan, and has additional presence in Berlin, Germany, and Warsaw, Poland. RTA Ventures specializes in a range of sectors including healthcare, information technology, software as a service (SaaS), and mobile technologies. The firm aims to identify and support innovative companies that demonstrate potential for growth, particularly those with business models centered around digital solutions and marketplaces.

Muditā Venture Partners is a venture capital investment firm based in Bingham Farms, Michigan, founded in 2022, that backs early-stage technology companies. The firm targets software, educational technology, financial technology, property technology, and AI-based sectors, seeking to support innovative startups from seed to early growth.