Grand Angels

ONL Therapeutics is a biopharmaceutical company dedicated to protecting vision through the protection of photoreceptors. It was founded in 2011 and is headquartered in Ann Arbor, Michigan.

KitoTech Medical is a medical device company developing and commercializing products for wound closure and wound care. It has developed and introduced a revolutionary proprietary wound closure product, microMend, onto the market. It incorporates tiny Microstaples on an adhesive backing, which is the size and shape of a butterfly bandage. microMend is painless and as easy to apply as a bandage. The Microstaples provide the holding strength of sutures resulting in secure anchoring of the device to the skin. These features make microMend ideal for closing surgical incisions and lacerations currently closed with sutures and staples. Clinical studies have demonstrated its superiority over sutures in terms of clinical outcomes, including cosmetic results. It is much faster than sutures and can be applied by less costly medical personnel (nurses, PAs, and nursing assistants) translating into significant cost savings in wound closure procedures. microMend is being marketed in a broad range of surgical specialties as well as dermatology and emergency medicine. The military represents an additional major market for microMend, where the product is also being commercialized. Its potential market is over $600M and $2B in the US and worldwide, respectively. KitoTech Medical was founded in 2011 and is based in Seattle, Washington.

Ocuphire Pharma is a clinical-stage biopharmaceutical company focuses on the development and commercialization of therapies to treat patients with a variety of ophthalmic disorders. It is currently focused on providing a novel once-daily eye drop treatment option, Nyxol, to treat multiple front-of-the-eye disorders, including night vision disturbances, glaucoma, pharmacologically-induced mydriasis, and presbyopia. Nyxol eye drops are an investigational 505(b)(2) drug candidate in late-stage clinical development with over a decade of safety and efficacy data from Phase 1 and 2 trials. Part of their strategy is to explore opportunities to acquire additional ophthalmic assets for both the front and the back of the eyes and to seek strategic partners for global commercialization. The company was founded in 2018 and is headquartered in Farmington Hills, Michigan.

Ambiq Micro is an early-stage fabless semiconductor company that is developing ultra-low-power mixed-signal solutions for a new generation of wireless electronics. Ambiq Micro was founded in 2010 on the simple yet powerful notion that extremely low-power semiconductors are the key to the future of electronics. Through the use of their pioneering ultra-low-power technology, they help innovative companies around the world develop differentiated solutions that reduce or eliminate the need for batteries, lower overall system power, and maximize industrial design flexibility.

HistoSonics provides the Edison Platform, which uses advanced imaging and proprietary sensing technology to deliver non-invasive, personalized treatments with precision and control, and uses the science of histotripsy and focused sound energy to generate pressures to liquify and completely destroy targeted tissues at sub-cellular levels.

Micro-LAM Technologies offers cutting edge technology through its state-of-the-art retrofittable system that is set to be a game-changer in the advanced manufacturing industry. The hybrid laser-diamond cutting tool system provides profitable solutions for machining hard and brittle materials. It was established in 2012 and is based in Portage, Michigan.

Tetra Discovery Partners provides consulting services in drug discovery and development. They partner with Universities to commercialize intellectual property and conduct proprietary research on diseases affecting the central nervous system. Their research focuses on developing new treatments for depression and schizophrenia. Severe forms of depression affect 2–5% of the US population, while mood disorders impact 7% of the world’s population and rank among the top ten causes of disability.

Tetra Therapeutics is a clinical stage biotechnology company developing a portfolio of therapeutic products that will bring clarity of thought to people suffering from Fragile X syndrome, Alzheimer's disease, traumatic brain injury, and other brain disorders.

Reconstruct’s a platform provides a ‘virtual command center’ of project replicas that enables project executives to more proactively and precisely manage construction progress including detecting current, past, and future performance issues. The platform’s 3D timelines enable near real-time coordination among general contractors, subs, owners, and lenders. The company was founded in 2016 and is based in Menlo Park, California.

Bindplane builds cutting-edge observability tools for businesses, private users, and open-source projects. Our mission is to advance observability technology by promoting and contributing to open-source communities. We are a proud partner of the OpenTelemetry project. Docs: https://bindplane.com/docs

Gemphire Therapeutics manufactures and markets Gemcabene, an LDL cholesterol-lowering medication. It is a clinical-stage biopharmaceutical company that is committed to helping patients with cardiometabolic disorders, including dyslipidemia and NASH. The company was founded in 2014 and is based in Northville, Michigan.

HistoSonics provides the Edison Platform, which uses advanced imaging and proprietary sensing technology to deliver non-invasive, personalized treatments with precision and control, and uses the science of histotripsy and focused sound energy to generate pressures to liquify and completely destroy targeted tissues at sub-cellular levels.

Tetra Discovery Partners provides consulting services in drug discovery and development. They partner with Universities to commercialize intellectual property and conduct proprietary research on diseases affecting the central nervous system. Their research focuses on developing new treatments for depression and schizophrenia. Severe forms of depression affect 2–5% of the US population, while mood disorders impact 7% of the world’s population and rank among the top ten causes of disability.

Bindplane builds cutting-edge observability tools for businesses, private users, and open-source projects. Our mission is to advance observability technology by promoting and contributing to open-source communities. We are a proud partner of the OpenTelemetry project. Docs: https://bindplane.com/docs

VNN is the largest and fastest growing high school sports marketing platform in America. As the exclusive web/mobile platform for over 7million passionate fans across 40+ states (adding 8,000 fans daily), VNN is rapidly aggregating the fragmented, multi-billion dollar high school sports market onto an intelligent platform that transforms the consumer experience of high school sports.

Tetra Discovery Partners provides consulting services in drug discovery and development. They partner with Universities to commercialize intellectual property and conduct proprietary research on diseases affecting the central nervous system. Their research focuses on developing new treatments for depression and schizophrenia. Severe forms of depression affect 2–5% of the US population, while mood disorders impact 7% of the world’s population and rank among the top ten causes of disability.

Bindplane builds cutting-edge observability tools for businesses, private users, and open-source projects. Our mission is to advance observability technology by promoting and contributing to open-source communities. We are a proud partner of the OpenTelemetry project. Docs: https://bindplane.com/docs

AzulStar is a privately held provider of 4G wireless Internet and communications services to commercial and government customers. Leveraging open standards wireless technology and an all IP wireless architecture, AzulStar delivers unprecedented levels of broadband performance and reliability. AzulStar has pioneered the market for wireless broadband access and won awards for the company's innovation and service quality. With carrier-class networks in the top markets of Michigan and New Mexico, AzulStar offers a variety of high value services including high-speed Internet Access, managed wireless networking and intelligent transportation.

Tetra Discovery Partners provides consulting services in drug discovery and development. They partner with Universities to commercialize intellectual property and conduct proprietary research on diseases affecting the central nervous system. Their research focuses on developing new treatments for depression and schizophrenia. Severe forms of depression affect 2–5% of the US population, while mood disorders impact 7% of the world’s population and rank among the top ten causes of disability.

TransCorp Spine manufactures medical devices and procedures to restore spinal function and preserve healthy tissue. Its product includes SpinePort, a MIS access system. David Lowry, Des O'Farrell, and Scott Tuinstra founded TransCorp Spine in 2008. It has its headquarters in Byron Center in Michigan.

Janeeva provides the most comprehensive set of software to both users and providers of outsourcing services for Outsourcing Relationship Management (ORM). The Janeeva Assurance family of products provides a one-stop shop for governance activities of outsourced operations. With Janeeva Assurance, governance groups, providers and internal customers know exactly where to go to arrange for additional resources, raise or manage an issue, track SLAs, or compare performance across multiple providers. The transparency that can be achieved with Janeeva Assurance and the institutional memory it creates, increases efficiency of interactions, promotes trust and minimizes missed opportunities. And the wealth of data collected by Janeeva Assurance can be mined to identify trends, process bottlenecks and best practices.

Accuri Cytometers was founded to address a compelling need: life scientists love the rapid cell-by-cell analysis capability of flow cytometers, but too few have a flow cytometer in their lab. The barriers for most researchers include cost of the instrument, complexity of the software, effort required for maintenance, and the large amount of bench space required for the instrument. As a result, the company is looking to develop affordable and robust cytometers.