Ann Arbor SPARK

SecuritySnares specializes in providing solutions to combat malware-related business disruptions. Its primary offering, RansomSnare, is an innovative tool designed to detect and prevent ransomware attacks by halting malicious encryption before any files are compromised. This lightweight micro-agent operates silently on endpoints and can function without signatures, learning periods, or updates, making it suitable for offline use and compatible with older operating systems often found in industrial and healthcare settings. In addition to RansomSnare, the company offers WiperSnare, which addresses the emerging threat of wipers—malware that corrupts or erases files irreversibly. SecuritySnares' products are engineered to complement existing security measures, providing immediate protection against sophisticated cyber threats.

360ofme is a new platform that provides consumers with portability, ubiquity and insights from their digital life. From healthcare to financial and insurance to automotive and home, 360ofme provides a simple means of securely sharing critical data with family members, doctors and others that consumers choose. Utilizing cognitive computing from IBM, new insights about people's lives will be surfaced. Consumers will gain control of their digital footprint. Visit 360ofme.com for more information.

GM&T Engineering specialises in the research and development, engineering, and testing of Electrical Distribution Systems (EDS) for the automotive, aerospace, and appliance industries.

Flightpath Biosciences is a biotechnology company based in Berkeley, California, founded in 2019. It specializes in developing innovative therapies aimed at treating rare infectious diseases, particularly those caused by pathogenic bacteria. The company's focus includes antibiotic therapies that target co-infectious bacteria in conditions such as Lyme disease, aiming to reduce microbiome damage and address multiple pathogenic bacteria in both the oral and gut microbiomes. By collaborating with leading scientists and experts in therapeutics and diagnostics across various academic institutions and government agencies, Flightpath Biosciences is committed to exploring diverse fields of biology to create novel and targeted treatment solutions.

Loansense is a debt management platform designed to assist borrowers in reducing their student loan debt and achieving homeownership. The company provides tools for setting financial goals and personalizing debt repayment plans, which help improve borrowers' debt-to-income ratios. By collaborating with networks in mortgage technology and mortgage brokerages, Loansense facilitates quicker mortgage closings for student loan debtors. The platform offers comprehensive financial planning, student loan servicing, and advisory services, enabling users to navigate the complexities of debt management and transition smoothly into homeownership.

Asalyxa Bio, Inc. is a drug development company based in Southfield, Michigan, specializing in novel therapeutics aimed at addressing significant unmet medical needs resulting from the dysregulation of immune signaling. The company has developed a platform technology that facilitates the targeted delivery of both existing and innovative drugs directly into over-reactive immune cells. This approach is particularly focused on combating severe neutrophil-mediated diseases, including conditions such as Covid-19, and has applications across a broad range of disease areas. By leveraging this technology, Asalyxa Bio aims to enhance treatment options and improve patient outcomes in various therapeutic contexts.

Orbion Space Technology, based in Houghton, Michigan, specializes in the development and manufacture of plasma propulsion systems for small satellites. Founded in 2016, the company provides advanced electric propulsion technology that enhances satellite functionality by enabling precise maneuverability in space. Orbion's thrusters facilitate essential tasks such as the last-mile delivery of spacecraft from launch vehicles to their designated orbits, extending the operational life of satellites, and ensuring safe de-orbiting at the end of their missions. By offering a cost-effective solution that can significantly reduce operational expenses for spacecraft operators, Orbion contributes to the growing demand for efficient propulsion systems in the rapidly evolving space industry.

Barracuda Networks specializes in providing online security products and services designed to protect organizations from a range of security threats, both on-site and in the cloud. Founded in 2002 and headquartered in Campbell, California, the company offers a variety of solutions, including email and web security appliances, data backup services, and network performance enhancements. Key products include the Barracuda Spam Firewall, which safeguards email servers from spam and malicious attacks, the Barracuda Web Filter for enforcing internet usage policies, and the Barracuda Backup Service for secure data storage and disaster recovery. Barracuda Networks serves multiple industries, including education, government, healthcare, and finance, with a distribution network that spans the United States and international markets. The company is committed to delivering comprehensive protection against enterprise-level threats, allowing organizations to manage their security needs from a centralized console.

SPLT is an enterprise-first carpooling and car sharing platform that connects employees within organizations to share their commute, saving time and money while reducing traffic congestion and lowering CO2 emissions.

Banza LLC is a food manufacturer based in Detroit, Michigan, that specializes in producing and wholesaling chickpea pasta. Founded in 2014, the company offers a variety of pasta shapes, including penne, rotini, shells, and elbows, aimed at providing nutritious comfort food alternatives. Banza's products are designed to be high in protein and fiber, allowing consumers to enjoy their favorite meals without compromising on health. The pasta is available in approximately 8,000 retail locations across the United States, including major stores such as Target, Kroger, and Whole Foods. Banza has received notable recognition, being featured in prominent publications like The New York Times and Bon Appetit, and has been celebrated as one of TIME Magazine's 25 Best Inventions of the Year.

TurtleCell is a mobile accessories company that specializes in innovative protective cases for popular smartphones. Its flagship product features a unique design that incorporates retractable earbuds stored within the case, allowing users to keep their headphones secure and untangled while providing essential protection for their devices. This proprietary mechanism enables the storage of a full-length headphone cord within a case that is thinner than typical external battery cases, offering both functionality and style. TurtleCell aims to address common issues faced by smartphone users, such as losing or damaging their headphones, while delivering an effective and aesthetically pleasing solution.

Argo Labs' team has designed and developed on the web for small businesses with one employee and large corporations with thousands, learning a lot of do’s and dont’s along the way. The company builds sites from the ground up, shot videos for local businesses and families and designed entire online brands. Not to mention we have a perfect track record of meeting each of them one on one to make whatever they need 100% unique. The company combines backgrounds in computer science, engineering, videography, graphic design, marketing, and entrepreneurship. Everyone at Argo Labs has owned or worked for small businesses and has done freelance work on their own.

SkySpecs, Inc. specializes in developing unmanned aerial vehicles and associated technologies to automate operations and maintenance within the wind energy sector. Founded in 2012 and headquartered in Ann Arbor, Michigan, with an additional office in Amsterdam, the company offers a range of services including analytics, engineering projects, and wind turbine blade services. Its solutions feature collaborative software for data management and analysis, digitization of data, and comprehensive planning for repair campaigns. SkySpecs also provides Horizon, a reporting and collaboration tool that serves as a central repository for blade operation and maintenance data, facilitating streamlined tasks and communication with third parties. The company's focus is on enhancing productivity, efficiency, and returns for its clients in renewable energy asset management.

CureLauncher is a company focused on enabling users find suitable medical treatments based on their conditions. It carries out its operations from Bloomfield Hills, Michigan.

Axonia Medical's proprietary approach is to repair and restore damaged peripheral or central nervous systems using tissue-engineered nerve grafts. They are expected to bridge lost nervous tissue and jump-start regenerative mechanisms to achieve levels of functional recovery not possible with current technologies.

Algal Scientific Corporation, founded in 2009 and based in Plymouth, Michigan, specializes in developing and selling algae-based products and technologies for the animal health, human nutrition, and wastewater treatment industries. The company produces Algamune, a beta glucan derived from algae, which enhances the immune health of various livestock and aquatic species, and AlgaGLUCAN, a similar product aimed at human nutraceuticals and functional foods. Additionally, Algal Scientific offers the Hypertrophic wastewater treatment system, designed for the food and beverage sector, which effectively treats dissolved organics, nitrogen, and phosphorus while generating a natural fertilizer co-product. With a focus on sustainable practices, Algal Scientific serves both domestic and international markets, contributing to advancements in health and environmental conservation.

TM3 Systems develops smart, mobile microgrid products for remote and off-grid power applications.

TM3 Systems develops smart, mobile microgrid products for remote and off-grid power applications.

Seelio is an online platform that allows college students to create and showcase digital portfolios to potential employers. Founded in 2011 and based in Ann Arbor, Michigan, it focuses on providing custom portfolio networks and galleries tailored for engineering, design, and business programs. This platform empowers students to document their learning experiences and display their projects effectively. Seelio has partnered with several prominent educational institutions, including the Massachusetts Institute of Technology, the University of Michigan, and the University of Texas at Austin, enhancing the visibility of students' work to recruiters and industry professionals. The company has received venture backing and has gained recognition in notable publications such as Forbes and TechCrunch.

AutoBike has developed an automatic shifting technology that it will feature on its own line of bicycles as well as on other bicycle OEM's product lines.

Eloquence Communications is a healthcare IT company that is dedicated to improving the delivery of care through the development of innovative and simple communication solutions. It develops nurse-call systems through a communication technology called Eloquence which provides patients with bi-directional remote communication with their care providers. The company's two products, Eloquence Advanced Communication System (ACS) and Eloquence Language Access Solution (LAS) enable fast, accurate communication between the patient and the provider best qualified to give the care that’s needed.

Quikly Inc., based in Detroit, Michigan, operates a marketing platform designed to assist consumer brands in executing targeted campaigns that reward both new and existing customers. Founded in 2012, Quikly provides a range of marketing solutions, including email, social, mobile, loyalty, and local marketing, aimed at enhancing customer engagement and driving key behaviors such as purchases and store visits. By leveraging insights from consumer psychology, Quikly’s technology enables brands to boost digital activation and engagement effectively, leading to improved return on investment. The platform is particularly beneficial for digital marketers in sectors such as retail, dining, and consumer-packaged goods, facilitating customer acquisition, activation, and retention through innovative strategies that emphasize scarcity, anticipation, and competition.

AlertWatch, LLC is a clinical decision support system provider based in Ann Arbor, Michigan, established in 2011 as a spinoff from the University of Michigan Health System. The company develops software products, specifically AlertWatch:OR and AlertWatch:ICU, designed to enhance patient monitoring in operating rooms and intensive care units. These systems aggregate data from various sources, including physiological monitors, anesthesia records, lab results, and medical histories, to present a real-time overview of a patient’s condition using a color-coded system to indicate normal, marginal, or abnormal states. AlertWatch:ICU functions as a secondary patient monitor and provides additional features like data trends, SOFA and SIRS scores, alerts specific to ICU settings, and nursing reminders. The company's products are currently implemented at the University of Michigan and several other training hospitals across the United States.

Beet provides diagnostic and analytical tools to accelerate problem-solving for complex assembly and automation challenges. It is a smart manufacturing solution provider founded in June 2011 and provides Process Visibility System (PVS) built upon ENVISION, the software created by BEET. PVS is a new way to manage the manufacturing shop floor. It helps to transform the shop floor culture from reactive to proactive and enables predictive maintenance. The solution implemented through PVS will maximize the capacity of existing assets by reducing the unplanned downtime and increasing the production throughput, helping sustain higher throughput by providing pinpoint and accurate information to the right people at the right time. ENVISION takes advantage of its proprietary technology to collect, process, and present data down to the motion of each device of a production line. ENVISION plays a vital role for manufacturers pursuing Industrial IoT, which, in turn, leads to Industry 4.0.

Advanced Battery Concepts, LLC is a company specializing in the design and development of bi-polar lead acid batteries. Founded in 2008 and based in Clare, Michigan, it aims to enhance battery performance across various sectors, including military, industrial, stationary, renewable, automotive, and motive markets. The company focuses on advancing battery electrode technologies to address the challenges associated with bipolar batteries. Its innovative products offer uniform current density, increased active material utilization, and improved energy and power density, which contribute to enhanced performance at lower production costs compared to conventional lead-acid batteries. Advanced Battery Concepts was previously known as Advanced Battery Concepts Michigan before rebranding in March 2011.

3D Biomatrix Inc. specializes in designing and manufacturing three-dimensional cell culture plates and scaffolds, specifically tailored for cellular assays in drug discovery. Founded in 2010 and located in Ann Arbor, Michigan, the company offers its products in 96- and 384-well plate formats, enhancing the ability of researchers to conduct sophisticated experiments. The scaffolds developed by 3D Biomatrix are utilized in various applications, including bone marrow, hepatocytes, and thymus, aiding researchers and drug discovery professionals in their efforts to treat cancer and tumors.

Fusion Coolant Systems, Inc. specializes in manufacturing and marketing advanced coolant and lubrication systems for various manufacturing industries. The company offers products such as Pure-Cut 1000 and LUBE-CUT 1600, which utilize supercritical carbon dioxide for dry lubrication and efficient cooling during cutting processes. These systems are designed to enhance production rates and extend tool life while addressing the limitations of traditional metalworking fluids, which often contain harmful chemicals and contribute to environmental pollution. Fusion Coolant's patented CHiP Lube system represents a significant advancement in metalworking technologies, improving operational efficiency and promoting worker safety. The company serves diverse sectors, including medical, aerospace, automotive, and power generation, and also provides infrastructure solutions like carbon dioxide storage tanks and pumps. Founded in 2009 and headquartered in Canton, Michigan, with an office in Saint-Priest, France, Fusion Coolant has established a strategic partnership with Air Liquide to further its innovations in coolant technology.

Larky, Inc. is a marketing and engagement platform that specializes in connecting organizations with their audiences through targeted geo-notifications and relevant communications. The company offers two main products: a nudge mobile platform, which facilitates audience engagement via location-based notifications, and Larky Classic, a mobile engagement solution designed to enhance communication with members, support local businesses, and foster loyalty. Additionally, Larky provides a merchant-funded loyalty platform that enables users to receive instant savings at local merchants. Larky serves a diverse client base, including financial institutions, health insurance providers, universities, and media companies across the United States and Canada. Founded in 2011 and headquartered in Ann Arbor, Michigan, Larky was previously known as PerkPerk, Inc.

Algal Scientific Corporation, founded in 2009 and based in Plymouth, Michigan, specializes in developing and selling algae-based products and technologies for the animal health, human nutrition, and wastewater treatment industries. The company produces Algamune, a beta glucan derived from algae, which enhances the immune health of various livestock and aquatic species, and AlgaGLUCAN, a similar product aimed at human nutraceuticals and functional foods. Additionally, Algal Scientific offers the Hypertrophic wastewater treatment system, designed for the food and beverage sector, which effectively treats dissolved organics, nitrogen, and phosphorus while generating a natural fertilizer co-product. With a focus on sustainable practices, Algal Scientific serves both domestic and international markets, contributing to advancements in health and environmental conservation.

Local Orbit is a business management tool provider that focuses on enhancing the food system within the connected food economy. The company has developed an elegant platform that facilitates multi-channel sales, streamlined purchasing, and efficient business management for various stakeholders in the food supply chain. This includes farmers, food producers, chefs, and independent distributors. By addressing the challenges of disconnected markets and inefficient communication, Local Orbit supports entrepreneurs and local producers in building effective relationships with wholesale buyers, thereby enabling the development of emerging supply chains.

Envy Modular Wall Systems (MWS) came about from a culmination of many, many years of construction and business experience. Founder and CEO Doug Spear saw the need for a modular wall system that could transcend the boundaries of many industries, yet provide the strength and durability to handle the industrial construction barricade service it was originally developed for.

Mitostem, Inc. was founded in 2008 with the goal to drive innovation, and accelerate the scientific breakthroughs that will advance Stem Cell research and the field of Regenerative Medicine. MitoStem focuses on developing and commercializing novel technologies to advance stem cell research and the field of regenerative medicine. Stem cells have the ability to reproduce themselves (self-renew) or differentiate into each of the cell types found in the body. In the future, Pluripotent Stem Cells (PSC) will be able to replace diseased and damaged organs. Until recently, only stem cells derived from embryos were pluripotent. However, controversies are associated with using cells from embryos, and they can only be used for study of diseases that are diagnosed during assisted reproduction procedures (in vitro fertilization).

Millendo Therapeutics is a biopharmaceutical company dedicated to developing innovative treatments for endocrine diseases resulting from hormone dysregulation. The company focuses on addressing significant unmet medical needs by creating distinct therapies that improve clinical care. By leveraging scientific advancements, Millendo aims to develop novel compounds that can effectively treat complex conditions, ultimately enhancing the quality of life for patients, families, and caregivers.

FreeStride Therapeutics, Inc. specializes in developing innovative therapies for companion animals, with a focus on treating conditions such as arthritis and lameness. The company aims to go beyond mere pain relief by addressing the underlying mechanisms that promote healing in horses, dogs, and cats. FreeStride is committed to creating safe and effective treatments that enhance the quality of life for pets, allowing them to lead active lifestyles. The management team brings extensive expertise from biotechnology, research, and drug development, ensuring a strong foundation for their initiatives. Additionally, FreeStride's healthcare platform offers therapeutic services targeting inflammation and bone loss, providing veterinary practitioners with high-quality products to improve animal health outcomes.

Seelio is an online platform that allows college students to create and showcase digital portfolios to potential employers. Founded in 2011 and based in Ann Arbor, Michigan, it focuses on providing custom portfolio networks and galleries tailored for engineering, design, and business programs. This platform empowers students to document their learning experiences and display their projects effectively. Seelio has partnered with several prominent educational institutions, including the Massachusetts Institute of Technology, the University of Michigan, and the University of Texas at Austin, enhancing the visibility of students' work to recruiters and industry professionals. The company has received venture backing and has gained recognition in notable publications such as Forbes and TechCrunch.

Axonia Medical's proprietary approach is to repair and restore damaged peripheral or central nervous systems using tissue-engineered nerve grafts. They are expected to bridge lost nervous tissue and jump-start regenerative mechanisms to achieve levels of functional recovery not possible with current technologies.

Celsee Diagnostics (formerly DeNovo Sciences) mission is to provide an easy to use platform for cancer research and diagnosis. Specifically, the company will sell an instrument system and reagent kit that allows for the separation, detection, and retrieval of circulating tumor cells (CTCs) from peripheral whole blood as an alternative to traditionally painful and invasive biopsies. Their company is developing a proprietary product that will not only allow researchers to identify and capture rare and difficult to harvest cancer cells in a microfluidic chip but also enable them to conduct downstream molecular analysis. This technology allows for the development of personalized therapies as well as the ability to monitor patient prognosis.

Oxus is a technology company that designs and manufactures oxygen concentrator products for several markets. Oxus has been in business for over 13 years. Oxus is proud to manufacture the Oxus Portable Oxygen Concentrator in the USA.

Blaze Medical Devices, LLC, founded in 2006 and based in Ann Arbor, Michigan, specializes in developing biomedical equipment for assessing the properties of stored blood, particularly focusing on red blood cells. The company offers advanced technologies, including the RBC Mechanical Fragilimeter™ and RBC Hemolysis Tester systems, which measure the mechanical fragility of red blood cells. These products cater to a range of industrial research and development needs, as well as future medical applications. By providing standardized assessments of blood cell damage, Blaze Medical Devices supports product developers and clinical researchers in understanding and mitigating quality loss during blood storage.

First Sense Medical specializes in developing non-invasive medical devices aimed at enhancing breast cancer screening. The company's primary product, the Breast Exam, utilizes advanced thermal profiling technology to detect abnormal heat patterns in breast tissue. This non-invasive test identifies physiological changes that may indicate an increased risk of breast cancer, providing healthcare professionals with valuable information for risk assessment in women of all ages. The Breast Exam system integrates patient biopsy data, compares it against national databases, and continuously updates its algorithms to improve accuracy and effectiveness, ensuring that the device remains at the forefront of medical technology in the fight against breast cancer.

FlockTAG is a universal loyalty card network that brings advantages to independent neighborhood businesses. FlockTAG is changing the way local businesses reward loyalty by making it easier for them, and more meaningful for their customers. Stop by your favorite participating FlockTAG business, grab a card and register to start earning rewards and deals! Earn points and rewards with FlockTAG at the following venues!

Ventech, LLC specializes in providing mobile heating solutions, primarily through its flagship product, the Liquid Heat Generator (LHG). This innovative system is designed for portable applications, generating heat quickly and efficiently by utilizing proprietary technology. Ventech's product offerings include various components such as vehicle harnesses, control modules, mounting brackets, dashboard switches, and other essential parts tailored for school buses, mass transit, and bus original equipment manufacturers (OEMs). The company serves clients in the transportation sector, including diesel generators, pickup trucks, and emergency vehicles, focusing on reducing fuel consumption, lowering emissions, and enhancing overall comfort and engine longevity. Ventech operates through a network of dealers across the United States and Canada and is headquartered in Wixom, Michigan. Founded in 2003, the company continues to pursue opportunities in transportation and commercial vehicle markets.

Empirical Bioscience LLC designs and manufactures high-grade molecular biology products used in polymerase chain reactions (PCR) of human, animal and plant DNA. Empirical Bioscience reagents have been optimized for use in next generation sequencing, translational research, agricultural applications, clinical diagnostics and education. The company recently introduced its rEVAlution qPCR Master Mix, an environmentally safe, ready-to-use hot-start qPCR mixture, to round out its line of offerings that includes the Taq 2x MeanGreen Master Mix, a ready-to-use 2x mixture of Taq DNA Polymerase, dNTPs, buffers and magnesium for efficient PCR amplification.

VNN, Inc. operates a leading high school sports marketing and networking platform that enables athletes to share videos, pictures, stories, and scores via various digital devices. The platform also allows coaches to report game results to media outlets, enhancing the visibility of high school sports. Serving schools across more than 40 states, VNN has established itself as the largest and fastest-growing entity in the high school sports marketing sector, connecting over seven million fans and adding thousands of new users daily. Founded in 2010 and based in Grand Rapids, Michigan, VNN is dedicated to transforming the consumer experience in the multi-billion dollar high school sports market.

ePaySelect restructures monthly payments into smaller, more affordable payments that are much less than the customer expects. These automated payments are collected on paydays, held and paid to the lender on the due date. This eliminates late fees and protects credit ratings. Retailers benefit because smaller payments are inherently easier to sell. Customers include retailers like auto dealerships or anyone who needs help making monthly payments

Coliant Corporation manufactures and distributes rugged electrical devices and cables for the cold, wet, and high vibration powersport environment. It offers powersport connectors, tire inflaters, and battery charging products; heated clothing products, such as heated jacket liners, heated gloves, controllers, and cables; Luggage Electrix products, which include tankbag bulkheads, internal and external cables, and cable pass-thrus; mounting systems; power and adapter cables; and power distribution products, which include plugs, sockets, fuse blocks, terminal connections, tools, and starter motor wire kits for specific make and model vehicles. The company also provides socket kits, handlebar outlet with gadget mounting hole, cigarette handlebar outlet with gadget mounting hole, standard handlebar outlets, cigarette handlebar outlets, outlet kits that bolt-on to passenger footpegs, outlet kits for plastic panels, cigarette outlet panel kits, jumper cables, cable mounted powerlet outlets, cable mounted cigarette outlets, model specific bracket kits, and model specific panel kits. In addition, it offers direct power cables for Apple iPod, mini-USB devices, Garmin GPS units, radar detectors, and other appliances. Its products are installed on motorcycles, scooters, snowmobiles, all-terrain vehicles, utility vehicles, and personal watercrafts. The company offers its products to powersport vehicle manufacturers. The company provides its products through dealers and distribution outlets; and online in the United States, the United Kingdom, Europe, Asia, Australia, and internationally. Coliant Corporation was founded in 2001 and is based in Warren, Michigan.

Clean Emission Fluids, Inc. manufactures fueling and fluid dispensing solutions for the transportation industry. It also resells biofuels, clean diesel, and emission related fluids. The company’s product enables fleet operators, truck stops, gas stations, and municipal fleets to store and dispense fluids and fuels. Clean Emission Fluids, Inc. was incorporated in 2007 and is based in Grosse Pointe, Michigan.

Ix Innovations is dedicated to enhancing the usability of electrical test and measurement instrumentation.

Estrakon is a fabrication company who specializes in designing and creating eye-catching electronic signage and custom marketing media in a wide range of materials. With state-of-the art facilities in USA, UK and China, they are the company to choose when it comes to getting your brand seen. Just view their extensive portfolio to see some of the clients they have worked with. Estrakon is dedicated to staying ahead of the competition by performing extensive research and development and they are constantly improving the products and services they can offer your business. You can be assured that whatever you need, it will be crafted to your exact specifications, using only the highest-quality materials. They employ the very latest construction techniques to make your product durable, yet cost-effective enough to produce in large quantities. To complete a project successfully, Estrakon believes communication is key. You will be in close contact with their design and production teams from start to finish to ensure you receive product that meets your exact requirements.

APT has been formed to develop, manufacture, market, sell and service specialty additives and associated delivery systems, for the plastic resin industry.

Law Enforcement Intelligent Devices (LEID), LLC was originally founded to assist police departments in securing their assets (guns, weapons and radios) through an electronic tracking and fingerprinting system. LEID's products since have been utilized to track many other type of business assets such as radios at amusement parks; books, tapes and magazines within a library system; and even the securing of business documents to selected personnel.

RetroSense Therapeutics is a biotechnology company developing life-enhancing gene therapies designed to restore vision in patients suffering from blindness due to retinitis pigmentosa (RP) and advanced dry age-related macular degeneration (advanced dry-AMD). There are currently no FDA approved drugs to improve or restore vision in patients with these retinal degenerative conditions. The company's approach to using optogenetics in vision restoration is based on pioneering, proprietary research conducted at Wayne State University and Massachusetts General Hospital. Founded in 2009, RetroSense Therapeutics is headquartered in Ann Arbor, Michigan.

Practical EHR Solutions, Pehr for short (pronounced “pear”), is a company that specializes in implementing and supporting electronic health records in physician groups. Pehr's mission is to improve patient outcomes. As healthcare professionals, the Pehr founders understand just how important a physician’s individuality is and have developed a unique and practical electronic health record implementation methodology to preserve that individuality. Pehr focuses on enhancing the physician experience by improving the physician’s work day, increasing the practice’s profitability and improving quality and safety. This results in quick acceptance and full functionality use of the EHR. It is this use of full feature functionality that patient outcomes can, and will, improve.

Empirical Bioscience LLC designs and manufactures high-grade molecular biology products used in polymerase chain reactions (PCR) of human, animal and plant DNA. Empirical Bioscience reagents have been optimized for use in next generation sequencing, translational research, agricultural applications, clinical diagnostics and education. The company recently introduced its rEVAlution qPCR Master Mix, an environmentally safe, ready-to-use hot-start qPCR mixture, to round out its line of offerings that includes the Taq 2x MeanGreen Master Mix, a ready-to-use 2x mixture of Taq DNA Polymerase, dNTPs, buffers and magnesium for efficient PCR amplification.

ArborWind LLC is a green energy company based in Ann Arbor, Michigan, that specializes in the manufacturing and installation of vertical axis wind turbines. Founded in 2010, ArborWind focuses on providing economical and efficient energy solutions, particularly to rural areas. Its turbines are designed to meet the energy needs of various applications, including agricultural, industrial, commercial, and residential settings. By harnessing wind energy, ArborWind aims to minimize costly expenses, transmission losses, and logistical challenges often associated with traditional energy sources, thereby promoting sustainable energy generation.

Reveal Design Automation is an Electronic Design Automation (EDA) start-up developing software tools to address a critical challenge in the semiconductor chip design process: formal verification of complex chip designs. With fully automated solutions enabling highly scalable Architecture Validation, formal verification runs that take days with competing solutions can now be completed in hours with Reveal. Where a typical verification cycle for a new chip design requires dozens to hundreds of such verification runs, Reveal can save chip designers millions of dollars in verification expense, reduce time-to-market by months, and significantly improve confidence in chip design correctness.

Zipments is a local logistics platform that offers same-day delivery services to businesses and individuals. Customers can request local deliveries through its website, mobile app, or by utilizing an API integrated into various online retailers' shopping carts. The service caters to multiple sectors, including retail, professional services, and restaurants, providing an efficient solution for businesses seeking reliable delivery options. Additionally, Zipments serves consumers who require assistance with personal deliveries, making it a versatile choice for local logistics needs. The platform allows users to track packages and receive instant notifications, enhancing the delivery experience.

RetroSense Therapeutics is a biotechnology company developing life-enhancing gene therapies designed to restore vision in patients suffering from blindness due to retinitis pigmentosa (RP) and advanced dry age-related macular degeneration (advanced dry-AMD). There are currently no FDA approved drugs to improve or restore vision in patients with these retinal degenerative conditions. The company's approach to using optogenetics in vision restoration is based on pioneering, proprietary research conducted at Wayne State University and Massachusetts General Hospital. Founded in 2009, RetroSense Therapeutics is headquartered in Ann Arbor, Michigan.

NextCAT specializes in the commercialization of innovative catalysts designed for biodiesel production. Developed at the National Biofuels Energy Lab at Wayne State University, these catalysts enable producers to reduce overall production costs by optimizing feedstock usage and streamlining processing steps, resulting in higher efficiency. The company is backed by a team of experts in catalysis and an experienced management group, positioning it to significantly impact the biodiesel industry. By enhancing production methods, NextCAT aims to support a transition towards more sustainable energy sources, contributing to reduced dependence on foreign oil and a healthier environment.

Tangent Medical Technologies, a development stage medical device company, was founded in Ann Arbor in 2009 based on technology exclusively licensed from the University of Michigan's Medical Innovation Center. The Company's mission is to improve infusion therapy for patients and healthcare workers with its proprietary, intravenous catheters and associated products. Tangent is led by an experienced, successful management team and the original inventors of the technology. The Company expects to begin generating commercial revenues from its lead product, the NovaCath™ Closed IV Catheter System, in 2012.

Fulcrum Composites Inc is a Michigan based company dedicated to developing new products and bringing them to market. Although their product portfolio is diverse, they are linked by common themes of structural efficiency obtained by synergistic and often unconventional combinations of materials and manufacturing processes.

Armune BioScience, Inc. will develop and commercialize molecular diagnostic and prognostic tests for prostate, lung and breast cancers that will allow physicians and patients to make more personalized treatment decisions. The company was founded by members of the Apjohn Group, LLC, a business accelerator that brings together valuable resources of management talent and angel/seed financing. Armune's technology is based on research performed at the University of Michigan under Dr. Arul Chinnaiyan's direction and published in the New England Journal of Medicine (NEJM 2005; 353:1224-1235), and the work done and published by Dr. David Beer, also at the University of Michigan (Cancer Res 2007;67(7):3461–7). Armune has secured an exclusive license from the University of Michigan for this technology.

Inventure Enterprises Inc. provides management consulting and technology services. The company offers application development and modernization, and business intelligence services; composite application and portal services that enable users to make business decisions by leveraging an enterprise’s applications, information, processes, and communities of interest; and mobile applications services for mobile employees to access a range of corporate services and information. It also offers idView, a background check suite that manages background processes from initial requests to delivery of results and final dispositions of applicants. The company provides its solutions to customers in federal and state government, defense, security, manufacturing, financial, energy, transportation, and healthcare industries in the United States and internationally. Inventure Enterprises is based in East Lansing, Michigan.

Current Motor fills the unmet need for fast, fun, affordable, zero-emission, electric vehicles (EVs). Current Motor develops and manufactures all-electric maxi-scooters for the Americas, made in Michigan. The company’s EVs use no gas, produce no emissions and create no maintenance hassles. Their maxi-scooters offer speeds up to 70 MPH and a range of up to 50 miles. They charge from a standard 110V household outlet in 5 hours. Backed by BELLE Capital, the State of Michigan and other private equity investors, please visit www.currentmotor.com for more information. They are shipping Test Pilot (beta) bikes with full production maxi-scooters scheduled to ship at the end of the 2011.

NextCAT specializes in the commercialization of innovative catalysts designed for biodiesel production. Developed at the National Biofuels Energy Lab at Wayne State University, these catalysts enable producers to reduce overall production costs by optimizing feedstock usage and streamlining processing steps, resulting in higher efficiency. The company is backed by a team of experts in catalysis and an experienced management group, positioning it to significantly impact the biodiesel industry. By enhancing production methods, NextCAT aims to support a transition towards more sustainable energy sources, contributing to reduced dependence on foreign oil and a healthier environment.

InfoReady Corporation specializes in developing web-based software solutions tailored for higher education institutions, focusing on streamlining workflow and grant application processes. The company's primary offerings include InfoReady Review, which connects researchers to relevant research grants, and InfoReady Thrive, a platform that consolidates scholarships, fellowships, internships, and study-abroad programs. InfoReady's applications enhance user productivity by facilitating information discovery, collaboration, and activity tracking. The company serves various academic entities, including research offices and student services, helping to manage selection and approval processes effectively. With a client base of over 200 institutions globally and a retention rate exceeding 90%, InfoReady is recognized for its commitment to operational efficiency and strong customer support. Established in 2010 and headquartered in Ann Arbor, Michigan, InfoReady addresses the unique needs of the academic sector, fostering better communication and engagement within educational communities.

Sentio MMG® is a surgical access tool. It is intended to locate and map motor nerve roots and their peripheral extensions originating from spinal levels C3-T1 and L2-S2. Sentio MMG® smart-sensors are different from all other forms of neuromonitoring electrodes. In contrast to electromyography, or EMG, which relies on needles to detect subtle changes in electrical signals in muscle, Sentio MMG® smart-sensors employ proprietary accelerometer technology. These non-invasive accelerometer-based sensors measure MMG (mechanomyography) activity, or the mechanical “twitch” associated with muscle contraction. When MMG activity is detected, the surgeon is provided with a ‘STOP’ alert indicating a nerve has been identified. The result is an intuitive, surgeon-directed tool for establishing safe access in a variety of surgical applications. Sentio MMG® was specifically designed to facilitate safe lateral transpsoas surgery. Sentio believed there was a better way to identify and map nerves during lateral surgery that did not require EMG. Design objectives included:

Trapelo Health is a healthcare technology company based in Cambridge, Massachusetts, that specializes in precision oncology. Founded in 2009, it has developed a collaborative decision support platform that provides evidence-based reports in molecular oncology. This platform aids physicians, payers, and laboratories by aligning molecular test results with corresponding therapies based on the latest medical evidence. By facilitating real-time access to crucial information, Trapelo Health supports oncologists in the analysis of cancerous tissues and the generation of genomic profiles, enabling them to identify appropriate treatments and make informed decisions regarding molecular diagnostics and targeted therapeutics. The company also maintains a strategic partnership with Concert Genetics to enhance its services.

Mandy & Pandy teaches kids Chinese in a fun and easy way through books, CDs, DVDs, toys, fashion, and television. Similarly, Mandy & Pandy teaches English to Chinese-speaking children.

RealBio Technology, Inc. is a life science product development company based in Kalamazoo, Michigan, founded in 2009. The company specializes in advanced cell and tissue culture technologies that enhance the growth and differentiation of human and non-human cells. Its flagship product, the Nth Degree System, is a disposable, single-use 3D perfusion bioreactor designed to create in vitro cultures that closely mimic natural in vivo environments. This innovative technology supports researchers in regenerative medicine, in-vitro modeling, and bio-production by allowing for controlled nutrient and gas gradients within the culture chamber. RealBio Technology serves scientists and healthcare professionals by providing tools that facilitate more realistic and effective research outcomes.

Algal Scientific Corporation, founded in 2009 and based in Plymouth, Michigan, specializes in developing and selling algae-based products and technologies for the animal health, human nutrition, and wastewater treatment industries. The company produces Algamune, a beta glucan derived from algae, which enhances the immune health of various livestock and aquatic species, and AlgaGLUCAN, a similar product aimed at human nutraceuticals and functional foods. Additionally, Algal Scientific offers the Hypertrophic wastewater treatment system, designed for the food and beverage sector, which effectively treats dissolved organics, nitrogen, and phosphorus while generating a natural fertilizer co-product. With a focus on sustainable practices, Algal Scientific serves both domestic and international markets, contributing to advancements in health and environmental conservation.

Azenic is a dental device company focusing on unmet market needs in the dental profession with emphasis on novel disposable instruments. Axenic Dental was founded in 2008 and is based in Kalamazoo, Michigan.

Michelle's Miracle, Inc. Aka. Cherry Works produces and sells Supplements based on a core ingredient of Montmorency tart cherry concentrate. We add value to the consumer seeking support for sleep, joint pain, and exercise recovery. Our label's can be found in retail specialists across North America. Our products promote healthy joint and cartilage function, the immune system, and cardiovascular function, cognitive function; DOMs for endurance athletes, and sleep hygiene. We sell our house labeled products online, as well as through health food stores and grocery stores. We also pack private label and are seeking more partnerships in custom formulated supplements. Michelle's Miracle, Inc. was formerly known as Leland Cherry Company, Inc. and changed its name in September, 2008. The company was founded in 2001 and is based in Traverse City, Michigan.

White Pine Systems, LLC (dba SPINN) is dedicated to delivering a complete solution for consumer-engaged healthcare that compliments existing health information technology investments. Their Internet-based patient engagement systems are at the core of the rapidly emerging “connected health” movement. Connected health uses technology to provide access to critical personal health information, improve communication between healthcare providers, patients and their families, and better manage chronic conditions to facilitate living normal lives.

Epsilon Imaging, Inc. specializes in the design and development of software and algorithms for cardiac ultrasound medical imaging. Based in Ann Arbor, Michigan, the company provides a vendor-neutral suite of applications that enhance workflow in echocardiography, including EchoInsight Pro for larger clinical practices, EchoInsight Stand-alone for smaller programs, and various EchoInsight Applications for managing echocardiography indications. These solutions incorporate innovative visualization and analysis technologies, such as clinical strain imaging, aimed at improving the quality and efficiency of cardiac diagnostics. Epsilon Imaging also offers robust customer support, with a team of technical and clinical specialists who provide training and consultation services to optimize the use of their products. Founded in 2008 and originally known as Ultrasound Medical Devices, Inc., Epsilon Imaging is committed to transforming cardiovascular patient management through streamlined and standardized echocardiography processes.

Base4 Biotechnology is focused on advancing RNA-targeted therapeutics through innovative small molecule modulation aimed at addressing previously untreatable diseases. Utilizing a proprietary structure-based discovery platform, the company integrates advanced computational technologies with experimental validation to explore and unlock the potential of RNA targets. This approach allows Base4 to tackle complex diseases across various therapeutic areas, including neurology, oncology, and rare diseases. By bridging the gap between computational discovery and practical application, Base4 aims to contribute significantly to the development of transformative medicines in the healthcare industry.

OcuSciences is a medical diagnostic device company that specializes in developing a non-invasive ocular imaging technique known as flavoprotein fluorescence (FPF). This innovative technology is designed to assess retinal metabolic activity, allowing for the detection and monitoring of retinal mitochondrial dysfunction and various retinal diseases, including diabetic retinopathy, macular degeneration, and glaucoma. By focusing on the ocular manifestations of diabetes, OcuSciences aims to provide ophthalmologists with a valuable tool to identify early signs of disease through indicators observed in the eye, ultimately enhancing patient care and treatment options.

Arbor Photonics, LLC, located in Ann Arbor, Michigan, specializes in the development of optical-fiber technology, focusing on advanced fiber laser systems. The company is dedicated to creating high-performance laser solutions that combine exceptional beam quality with significant optical power. Its innovations serve various sectors, including laser materials processing and defense applications, positioning Arbor Photonics as a notable player in the fiber laser market.

Biotectix, LLC develops and commercializes bioactive conductive polymer electrodes and coatings for electrodes used in medical devices. Its products are used in various medical devices, including pacemakers, cortical probes, cochlear implants, glucose sensors, and deep brain stimulators. The company offers its products to medical device manufacturers. Biotectix, LLC was founded in 2007 and is based in Quincy, Massachusetts.

Creative Byline, Inc. provides an online service that enables writers and editors to connect according to their interests and qualifications. Its Website brings together editors from various publishers and enables them to indicate their interests, as well as make a direct connection between the writer and interested editors. The company was founded in 2007 and is based in Holland, Michigan.

Armune BioScience, Inc. will develop and commercialize molecular diagnostic and prognostic tests for prostate, lung and breast cancers that will allow physicians and patients to make more personalized treatment decisions. The company was founded by members of the Apjohn Group, LLC, a business accelerator that brings together valuable resources of management talent and angel/seed financing. Armune's technology is based on research performed at the University of Michigan under Dr. Arul Chinnaiyan's direction and published in the New England Journal of Medicine (NEJM 2005; 353:1224-1235), and the work done and published by Dr. David Beer, also at the University of Michigan (Cancer Res 2007;67(7):3461–7). Armune has secured an exclusive license from the University of Michigan for this technology.

Fulcrum Composites Inc is a Michigan based company dedicated to developing new products and bringing them to market. Although their product portfolio is diverse, they are linked by common themes of structural efficiency obtained by synergistic and often unconventional combinations of materials and manufacturing processes.

ERT Systems, founded in 2005 by John Ellis, a veteran firefighter and incident commander, and Dennis Carmichael, an IT services entrepreneur, specializes in automated resource tracking systems for emergency responders. The company's technology offers a wireless solution that enables real-time tracking and locating of personnel and equipment during emergency situations. By automating this process, ERT Systems enhances the safety of both first responders and the public, addressing one of the key challenges faced by incident commanders in chaotic environments. The company developed a beta version of its product, which was first deployed at the Macomb College Firefighter Training Facility in 2006, marking the beginning of its commitment to improving emergency response operations through innovative technology.

The 3IS navigation structure is configured specifically for the automotive electronics industry. Linked to the navigation are a multitude of public and private domain industry specific databases. This combination produces the most accurate, comprehensive and relevant search results for technical or commercial data in the global automotive electronics industry.

Aursos, Inc., a biotechnology company, develops drugs for the treatment of bone loss. It develops black bear PTH (BB-PTH) 1-34 for the prevention and treatment of osteoporosis, as well as for patients suffering from disuse osteoporosis due to chronic immobilization. The company was founded in 2007 and is based in Kalamazoo, Michigan with an additional office in Houghton, Michigan.

AFID Therapeutics, Inc. specializes in developing chemical and biochemical technologies aimed at the design, discovery, delivery, and development of new pharmaceutical drugs. The company produces a diverse array of compounds, including lactones, esters, hydroxy cyclopentane carboxylic acids, amino acids, and advanced diamines, among others. AFID is also engaged in creating chiral chemical entities that mimic the structural and reactive characteristics of biomolecules, thereby influencing essential life processes. Its extensive screening collections feature various ring systems and functionalities, including piperazines, oxazolines, morpholines, and carbohydrate derivatives. The company leverages the structural complexity of carbohydrates to develop therapeutic interventions across a wide range of diseases, such as bacterial and viral infections, cancer, autoimmune disorders, cardiovascular diseases, diabetes, and neurological conditions like Alzheimer's. Its drug targets encompass a variety of enzymes and cellular components, including kinases, nucleases, and cell membranes. Established in 2003, AFID Therapeutics is located in Lansing, Michigan.

Global Energy Innovations Inc. provides alternate energy services. The Company manufactures fuel cell energy systems. Global Energy Innovations serves customers worldwide.

Emiliem, Inc is a private biotechnology company focused on understanding the molecular determinants of target modulation as it relates to the efficacy of therapeutics and to potential adverse drug reactions. The company is particularly interested in diagnostic markers for rare diseases and the computational aspects of predicting both positive and negative patient outcomes.

Vestaron Corporation specializes in the development, manufacture, and sale of peptide-based biologic crop protection products. Founded in 2005 and headquartered in Durham, North Carolina, with a research and development center in Kalamazoo, Michigan, Vestaron offers a range of bioinsecticides including Spear-T, Spear-Lep, and Leprotec, which target various pests in vegetables, fruits, and field crops. The company aims to enhance crop safety, efficacy, and sustainability by providing biopesticides that address resistance issues while ensuring safety for workers and the environment. Vestaron has received notable accolades for its innovative solutions, including the Bernard Blum Award and the Green Chemistry Challenge Award, recognizing its commitment to environmental stewardship and effective crop protection.

ITrack LLC has successfully completed its search for an investor/commercialization partner. They strongly believe that having an established and successful Michigan based engineering/ manufacturing company (Royal Oak Industries/ Grindstone Capital LLC) as an investor/business development collaborator will be very important to the commercialization their Department of Defense (DOD) funded ($4,500,000) navigation/ tracking technology. They plan to move their company operations from its Oakland University Business INCubator facilities to Royal Oak Industries U.S. headquarters in Lake Orion, Michigan in early 2010. This new home will provide iTrack LLC with the necessary office and engineering space along with the administrative, financial and overall commercialization support from Royal Oak Industries personnel.

Compendia Bioscience focuses on leveraging a comprehensive collection of cancer genomic data to enhance patient treatment options. The company specializes in providing genomic data and analytical tools designed for researchers involved in oncology drug discovery. By enabling the validation of biomarker and gene target discoveries, Compendia aims to facilitate the development of more effective cancer diagnostics and treatments.

RazorThreat, Inc. specializes in developing cybersecurity software aimed at protecting organizations from targeted cyber attacks that threaten intellectual capital and personally identifiable information. Founded in 2005 and based in Pontiac, Michigan, the company offers a comprehensive suite of tools, including the Threat Analysis Console (TAC), which manages and remediates network threats from various sources. Key components of TAC include the Inter-domain Communication Engine, which identifies communication violations against security policies, the Threat Intelligence Engine that transforms disparate data into actionable insights, and the Risk Intelligence Engine, which correlates vulnerability data with threat intelligence to create a detailed risk assessment. RazorThreat also provides integration and training services, focusing on personalized defense strategies that leverage existing security investments to enhance network security and respond to both internal and external threats in real time.

Vestaron Corporation specializes in the development, manufacture, and sale of peptide-based biologic crop protection products. Founded in 2005 and headquartered in Durham, North Carolina, with a research and development center in Kalamazoo, Michigan, Vestaron offers a range of bioinsecticides including Spear-T, Spear-Lep, and Leprotec, which target various pests in vegetables, fruits, and field crops. The company aims to enhance crop safety, efficacy, and sustainability by providing biopesticides that address resistance issues while ensuring safety for workers and the environment. Vestaron has received notable accolades for its innovative solutions, including the Bernard Blum Award and the Green Chemistry Challenge Award, recognizing its commitment to environmental stewardship and effective crop protection.

- NRGE is a Michigan based company providing advanced hydraulic solutions including hydraulic hybrids, piston accumulators, pressure vessels and engineering services to the off highway, marine, alternative fuel and energy storage markets and in the future to traditional industries that utilize the same. • NRG Enterprises predecessor company formed in 2004 and became venture backed in 2009 to focus on the On Highway Alternative Energy Marketplace and to specifically; • Design, Build, Test & Launch Hydraulic Hybrid Utilizing Compressed Gas for Energy Storage and Fuel Efficiency for On Highway Vehicles. • Company developed, applied for and patented numerous HH and piston accumulator patents that are still in effect today. • Additional information about NRG’s Hydraulic Hybrid History is found in the 'Archive History' section of the 'About Us' tab.

XG Sciences, Inc. is a privately held corporation with headquarters in Lansing, MI serving customers around the world. They manufacture xGnP brand Graphene Nanoplatelets, a new type of carbon nanoparticle, as well as conductive inks and coatings, electrodes, and specialty sheet products based on their materials. They ship products around the world from their 80-ton/year manufacturing plant in Lansing, and they also offer worldwide production capabilities through their licensees, POSCO and Cabot Corporation. Graphene nanoplatelets are particles consisting of short stacks of graphene sheets that are available in various thicknesses (2 to 20 nanometers) and various diameters (1 to 50 microns) for applications in automotive, aerospace, medical, electronics, and energy storage markets. They work with development partners ranging from national laboratories to universities and customers in 32 countries.

Phrixus Pharmaceuticals, Inc. is focused on developing and commercializing pharmaceuticals and therapies for heart failure, particularly in patients with Duchenne muscular dystrophy. The company's primary product, Carmeseal, is designed to treat heart failure by repairing muscle damage. Incorporated in 2006 and based in Ann Arbor, Michigan, Phrixus aims to provide cost-effective and efficient therapeutic solutions that support quick recovery for healthcare institutions and their patients.