Invest Michigan

Refraction AI, Inc. is an autonomous delivery robot company based in Ann Arbor, Michigan, founded in 2017. The company specializes in developing and deploying robotic platforms that facilitate last-mile goods delivery in urban environments. Its flagship product, the REV-1, is designed to autonomously navigate through city streets using an array of cameras, radar, and ultrasonic sensors, allowing it to pick up goods from restaurants, pharmacies, and grocery stores and deliver them directly to customers' homes. Refraction AI's technology is engineered to operate in various climates and can be monitored and operated remotely, ensuring efficient and reliable service. By enhancing the delivery process, Refraction AI aims to meet the increasing demand for faster, safer, and more cost-effective delivery solutions.

Shoulder Innovations designs and manufactures medical devices for shoulder replacement surgery, focusing on inset glenoid fixation technology to provide a stable glenoid platform and reliable fixation. Its product portfolio includes InSet Total Shoulder Arthroplasty, InSet Reverse Shoulder Arthroplasty, ProVoyance Shoulder Planning Software, and InSet Tray System, along with associated instrumentation. The company distributes its products through partners in the United States and aims to reduce operative time and overall healthcare costs while improving post-surgical implant stability. Founded in 2009, the company is based in Holland, Michigan.

Ripple Science develops web-based software for health sciences, facilitating participant recruitment and management in clinical, translational, and social science studies. Its platform offers features like study dashboard management, recruitment campaign tracking, potential participant monitoring, enrolled participant tracking, and task management. Serving academic investigators, clinical trial sites, and CROs, Ripple Science has clients including Johns Hopkins University and the University of Michigan.

Orbion Space Technology develops and manufactures plasma propulsion systems for small satellites, focusing on electric propulsion technology and space systems. Founded in 2016 and based in Houghton, Michigan, the company produces plasma thrusters designed for high-rate manufacturing to support the rapid deployment of small satellites. Its propulsion systems enable precise maneuvering, on-orbit life extension, collision avoidance, and end-of-life deorbit, as well as last-mile deployment from the launch vehicle to the destination orbit, with telemetry interfaces that monitor spacecraft status. By delivering efficient propulsion solutions, Orbion aims to reduce operating costs and enhance the value of satellite data for defense and commercial customers.

ONL Therapeutics is a biopharmaceutical company headquartered in Ann Arbor, Michigan, that develops small‑molecule peptide therapeutics to protect photoreceptors and preserve vision. Its pipeline focuses on targeting the FAS apoptotic pathway to prevent photoreceptor loss in retinal diseases such as retinal detachment, aiming to improve surgical outcomes and reduce vision loss. Founded in 2006, the company seeks to bring novel treatments for serious, vision‑threatening retinal conditions.

GreenMark Biomedical Inc. is a minimally invasive healthcare company focused on developing innovative technologies utilizing biopolymer nanoparticles derived from natural starch. Founded in 2016 and based in East Lansing, Michigan, with a laboratory in Ann Arbor, the company specializes in dental and medical applications. Its dental technologies include a mouth rinse product that illuminates cavities and early-stage lesions, allowing dentists to accurately diagnose and treat tooth decay. Additionally, GreenMark's medical technologies are designed for targeted delivery of anti-cancer drugs, enhancing treatment precision. The company aims to provide health benefits through its advanced nanoparticle-based solutions, promoting less invasive and more effective healthcare practices.

SpellBound, established in 2015 and headquartered in Ann Arbor, Michigan, specializes in developing immersive augmented reality tools tailored for hospital care teams. Their platform transforms books, spaces, and printed materials into interactive 3D experiences, aiming to enhance patient engagement during treatment, reduce healthcare costs, and improve overall patient experience. SpellBound's solutions are compatible with widely-used iOS and Android devices, making them easily accessible to therapists and families within hospitals.

Fusion Coolant Systems develops and markets advanced coolant and lubrication systems for metalworking and manufacturing, using supercritical carbon dioxide as a cutting fluid to improve production rates and tool life while reducing health, safety, and environmental risks. Its Pure-Cut 1000 system delivers dry-lubricated supercritical CO2, and LUBE-CUT 1600 combines CO2 with controlled lubrication for various cutting applications; the CHiP Lube system is highlighted as a significant advance in metalworking fluids. The company also provides infrastructure solutions, including carbon dioxide storage tanks, pumps, and related equipment. Its products are used in medical implants and instruments, automotive and heavy equipment, aerospace, defense, and power generation sectors. Fusion Coolant Systems has a strategic partnership with Air Liquide. The business was formerly known as Lean Fluid Systems and was renamed in 2009, and it operates from Canton, Michigan with an additional office in Saint-Priest, France.

Bloomscape is an online retailer specializing in houseplants. Founded in 2017, it offers a wide variety of plants, gift cards, and a unique 'Plant Mom' service for expert advice. The company aims to simplify plant buying and care, delivering fully grown, potted plants directly to customers' doorsteps.

Fifth Eye Inc. is a medical software company based in Ann Arbor, Michigan, specializing in real-time analytics for patient health monitoring. The company develops an innovative clinical decision support system that continuously analyzes a patient's hemodynamic status to predict the risk of instability. Its advanced software utilizes artificial intelligence to process real-time ECG data, enabling minute-to-minute assessments and providing healthcare professionals with early warnings of potential complications hours in advance of traditional methods. By offering continuous patient trajectory forecasts and historical trend analyses without requiring electronic health record inputs, Fifth Eye aims to enhance proactive patient care, improve clinical outcomes, and reduce hospital costs. Formerly known as Trove Analytics, Inc., Fifth Eye was incorporated in 2017 and rebranded in June 2018.

Mi Padrino is an event planning service dedicated to assisting families in organizing and funding celebrations rooted in Hispanic traditions, such as Quinceañeras, weddings, and baptisms. Founded by Kim Gamez, who recognized the complexities involved in coordinating these significant events, Mi Padrino offers a user-friendly platform that allows users to manage and share event details with friends and family worldwide. This innovative service streamlines the planning process by providing an all-in-one solution for event organization, enabling users to easily share their special moments and receive financial contributions from loved ones, regardless of their location. Through Mi Padrino, families can celebrate their traditions with greater ease and efficiency.

Ripple Science develops web-based software for health sciences, facilitating participant recruitment and management in clinical, translational, and social science studies. Its platform offers features like study dashboard management, recruitment campaign tracking, potential participant monitoring, enrolled participant tracking, and task management. Serving academic investigators, clinical trial sites, and CROs, Ripple Science has clients including Johns Hopkins University and the University of Michigan.

Ripple Science develops web-based software for health sciences, facilitating participant recruitment and management in clinical, translational, and social science studies. Its platform offers features like study dashboard management, recruitment campaign tracking, potential participant monitoring, enrolled participant tracking, and task management. Serving academic investigators, clinical trial sites, and CROs, Ripple Science has clients including Johns Hopkins University and the University of Michigan.