BioStar Capital

Founded in 1998, REVA Medical is dedicated to developing minimally invasive medical devices that leverage the Company's proprietary biomaterial and stent technologies to improve the treatment of disease. Guided by a management team and scientific advisors with extensive product development and clinical interventional cardiology experience, REVA's initial focus is the development of an innovative drug-eluting bioresorbable coronary stent and the commencement of clinical studies that will advance the treatment of coronary artery disease.

MMI S.r.l. is an Italian company that specializes in the manufacture and development of advanced micro instruments designed for surgical interventions. Founded in 2015 and based in Calci, Italy, MMI focuses on creating wristed micro instruments and their associated fabrication processes. The company also offers a proprietary robotic platform that enhances the capabilities of these instruments, facilitating complex reconstruction procedures following traumatic injuries and tumor removals in areas such as the breast, head, and bones. MMI aims to support surgeons globally by providing innovative tools that improve surgical outcomes while also reducing costs for patients and healthcare systems.

Ablative Solutions, Inc. is a medical device company focused on developing innovative solutions for the treatment of hypertension. Founded in 2011 and headquartered in San Jose, California, with an additional office in Kalamazoo, Michigan, the company specializes in endovascular catheters, particularly the Peregrine System. This catheter allows for the minimally invasive delivery of therapeutic agents into the perivascular space surrounding peripheral blood vessels. Ablative Solutions offers an alternative to surgical renal denervation, providing a safe, effective, and cost-efficient method to address hypertension and related conditions caused by an overactive sympathetic nervous system. The company aims to meet the significant medical need for effective treatments for patients with poorly controlled hypertension.

Foldax, Inc. is a company based in Salt Lake City, Utah, specializing in the design and manufacture of heart valves for individuals suffering from aortic, mitral, or tricuspid valve disease. Founded in 2013, Foldax focuses on developing synthetic heart valves that aim to be non-thrombogenic, providing a cost-effective alternative to existing artificial or tissue valves. The company offers its Tria biopolymer heart valves, which can be implanted either percutaneously or surgically, thereby addressing critical needs in cardiac care.

Aria CV was founded in 2010 by Drs. John Scandurra and Karl Vollmers, formerly Fellows at the University of Minnesota’s Medical Devices Center. Aria has an exclusive license to certain patents from the University of Minnesota. Aria CV’s device has the potential to improve outcomes by reducing the workload on the right side of the heart.

Trice Medical, Inc. specializes in developing orthopedic diagnostic devices that incorporate camera-enabled technologies and needle-based systems. Founded in 2011 and based in Malvern, Pennsylvania, the company aims to enhance orthopedic diagnostics by providing instant and accurate visual insights for patients, physicians, and payors. Trice Medical's innovative products facilitate minimally invasive procedures that can be performed in an office setting, offering painless and cosmetically undetectable solutions for both diagnostic and therapeutic purposes. The company's technology addresses the shortcomings of traditional diagnostic methods, significantly reducing false readings and overall healthcare costs, while optimizing the delivery of patient care.

Ablative Solutions, Inc. is a medical device company focused on developing innovative solutions for the treatment of hypertension. Founded in 2011 and headquartered in San Jose, California, with an additional office in Kalamazoo, Michigan, the company specializes in endovascular catheters, particularly the Peregrine System. This catheter allows for the minimally invasive delivery of therapeutic agents into the perivascular space surrounding peripheral blood vessels. Ablative Solutions offers an alternative to surgical renal denervation, providing a safe, effective, and cost-efficient method to address hypertension and related conditions caused by an overactive sympathetic nervous system. The company aims to meet the significant medical need for effective treatments for patients with poorly controlled hypertension.

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V-Wave Ltd. is a medical technology company based in Caesarea, Israel, with additional offices in the United States. Founded in 2009, it specializes in the development of percutaneous implantable therapeutic devices aimed at treating chronic heart failure (HF) patients, which is a major cause of morbidity and mortality worldwide. The company has created the V-Wave Shunt, a biocompatible inter-atrial unidirectional implant designed for patients with both preserved and reduced ejection fractions, addressing the needs of those who experience disabling symptoms despite optimal medical therapy. V-Wave's innovative approach focuses on relieving symptoms, reducing hospitalizations, enhancing exercise capacity, and improving overall quality of life for HF patients. The organization is backed by a team of experienced engineers and medical scientists who have a proven track record in developing and bringing various implantable cardiovascular devices to market.

Corindus Vascular Robotics, Inc. specializes in the design, manufacture, and commercialization of robotic-assisted systems for interventional vascular procedures. Based in Waltham, Massachusetts, the company offers the CorPath system, which allows physicians to perform catheterization procedures from a radiation-shielded control console, enhancing precision and safety in coronary and peripheral interventions. The CorPath GRX system further enables the robotic-assisted control of guide catheters, guidewires, and balloon/stent devices. Corindus serves various markets, including vascular, coronary, neurointerventional, and structural heart fields, selling its products through a combination of direct sales and partnerships. Founded in 2002, Corindus is a subsidiary of Siemens Medical Solutions USA, Inc. as of late 2019.

CathWorks Ltd. is a medical technology company based in Kfar-Saba, Israel, with an additional office in the United States. Founded in 2013, CathWorks specializes in developing advanced medical devices for the interventional cardiology market. The company's innovative technology leverages computational science and automatic multi-layered algorithms to enhance the utility of coronary angiography data, transforming visual assessments into objective decision-making tools for physicians. Its flagship product, CathWorks FFRangio, is a non-invasive device that provides objective multi-vessel physiological measurements, aimed at optimizing and confirming intra-procedural decisions for percutaneous coronary interventions (PCI). CathWorks is privately held and benefits from strong partnerships and support from leading venture capital firms in the medical devices sector.

Trice Medical, Inc. specializes in developing orthopedic diagnostic devices that incorporate camera-enabled technologies and needle-based systems. Founded in 2011 and based in Malvern, Pennsylvania, the company aims to enhance orthopedic diagnostics by providing instant and accurate visual insights for patients, physicians, and payors. Trice Medical's innovative products facilitate minimally invasive procedures that can be performed in an office setting, offering painless and cosmetically undetectable solutions for both diagnostic and therapeutic purposes. The company's technology addresses the shortcomings of traditional diagnostic methods, significantly reducing false readings and overall healthcare costs, while optimizing the delivery of patient care.

TransMedics is a medical technology company focused on improving organ transplant therapy for patients with end-stage organ failure. Headquartered in Andover, Massachusetts, it has developed the Organ Care System (OCS), a portable organ perfusion and monitoring device that mimics near-physiologic conditions for donor organs outside the human body. This system includes specialized devices for different organs, such as OCS LUNG, which maintains lungs in a viable state for assessment and optimization, OCS Heart, designed to preserve hearts in a metabolically active state, and OCS Liver, currently under clinical trials. By addressing the limitations of traditional cold storage methods, TransMedics aims to enhance organ preservation and increase the availability of organs for transplantation, thereby improving outcomes for patients in need. Founded in 1998, the company is at the forefront of innovation in organ transplant technology.

TransMedics is a medical technology company focused on improving organ transplant therapy for patients with end-stage organ failure. Headquartered in Andover, Massachusetts, it has developed the Organ Care System (OCS), a portable organ perfusion and monitoring device that mimics near-physiologic conditions for donor organs outside the human body. This system includes specialized devices for different organs, such as OCS LUNG, which maintains lungs in a viable state for assessment and optimization, OCS Heart, designed to preserve hearts in a metabolically active state, and OCS Liver, currently under clinical trials. By addressing the limitations of traditional cold storage methods, TransMedics aims to enhance organ preservation and increase the availability of organs for transplantation, thereby improving outcomes for patients in need. Founded in 1998, the company is at the forefront of innovation in organ transplant technology.

V-Wave Ltd. is a medical technology company based in Caesarea, Israel, with additional offices in the United States. Founded in 2009, it specializes in the development of percutaneous implantable therapeutic devices aimed at treating chronic heart failure (HF) patients, which is a major cause of morbidity and mortality worldwide. The company has created the V-Wave Shunt, a biocompatible inter-atrial unidirectional implant designed for patients with both preserved and reduced ejection fractions, addressing the needs of those who experience disabling symptoms despite optimal medical therapy. V-Wave's innovative approach focuses on relieving symptoms, reducing hospitalizations, enhancing exercise capacity, and improving overall quality of life for HF patients. The organization is backed by a team of experienced engineers and medical scientists who have a proven track record in developing and bringing various implantable cardiovascular devices to market.

Kona Medical, Inc. is a medical technology company based in Issaquah, Washington, founded in 2009 by Dr. Michael Gertner. The company specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. Its primary product, Surround Sound, is a hypertension therapy system that employs ultrasound imaging to precisely deliver focused ultrasound energy for renal denervation. This innovative approach targets the nerves associated with kidney function, offering a less invasive alternative for patients suffering from drug-resistant hypertension. By leveraging advancements in therapeutic focused ultrasound, Kona Medical seeks to improve treatment efficacy and reduce the health risks associated with high blood pressure.

Aria CV was founded in 2010 by Drs. John Scandurra and Karl Vollmers, formerly Fellows at the University of Minnesota’s Medical Devices Center. Aria has an exclusive license to certain patents from the University of Minnesota. Aria CV’s device has the potential to improve outcomes by reducing the workload on the right side of the heart.

Trice Medical, Inc. specializes in developing orthopedic diagnostic devices that incorporate camera-enabled technologies and needle-based systems. Founded in 2011 and based in Malvern, Pennsylvania, the company aims to enhance orthopedic diagnostics by providing instant and accurate visual insights for patients, physicians, and payors. Trice Medical's innovative products facilitate minimally invasive procedures that can be performed in an office setting, offering painless and cosmetically undetectable solutions for both diagnostic and therapeutic purposes. The company's technology addresses the shortcomings of traditional diagnostic methods, significantly reducing false readings and overall healthcare costs, while optimizing the delivery of patient care.

Conventus Orthopaedics provides a range of orthopedic and sports medicine services. The physicians specialize in orthopedic surgery, reconstructive surgery, spine surgery, joint replacement, sports medicine, physical therapy, and operative care of fractures, arthritis, strains, sprains, and sports-related injuries. Conventus was formed by a team of medical professionals with the sole purpose of creating less invasive ways to treat challenging periarticular fractures. By leveraging advanced nitinol technology, the Conventus team has developed a platform technology that provides robust fixation and creates reliable repairs. The company was incorporated in 2009 and is based in Maple Grove, Minnesota.

VytronUS, Inc. manufactures and markets cardiac medical devices. VytronUS, Inc. was formerly known as CardionUS, Inc. The company was founded in 2006 and is based in Sunnyvale, California.

Trice Medical, Inc. specializes in developing orthopedic diagnostic devices that incorporate camera-enabled technologies and needle-based systems. Founded in 2011 and based in Malvern, Pennsylvania, the company aims to enhance orthopedic diagnostics by providing instant and accurate visual insights for patients, physicians, and payors. Trice Medical's innovative products facilitate minimally invasive procedures that can be performed in an office setting, offering painless and cosmetically undetectable solutions for both diagnostic and therapeutic purposes. The company's technology addresses the shortcomings of traditional diagnostic methods, significantly reducing false readings and overall healthcare costs, while optimizing the delivery of patient care.

Domain Surgical is a medical device company that is creating energy-based surgical products for precise soft tissue cutting and coagulation. It creates energy-based equipment used in specialty surgical procedures. Its patent-pending technology produces surface-only tissue effects with energy that does not pass through the patient designed with the surgical staff in mind, for simple user-interface and training. The company manufactures and markets the FMwand Ferromagnetic Surgical System, a hemostatic dissection device that uses pure thermal energy to cut and coagulate soft tissue, without passing an electrical current through the patient. The FMwand imparts as little as 1/10th the amount of thermal injury compared to traditional electrosurgery devices. The FMwand provides fine dissection with a layer-by-layer precision that is unmatched by existing surgical technology.

Ablative Solutions, Inc. is a medical device company focused on developing innovative solutions for the treatment of hypertension. Founded in 2011 and headquartered in San Jose, California, with an additional office in Kalamazoo, Michigan, the company specializes in endovascular catheters, particularly the Peregrine System. This catheter allows for the minimally invasive delivery of therapeutic agents into the perivascular space surrounding peripheral blood vessels. Ablative Solutions offers an alternative to surgical renal denervation, providing a safe, effective, and cost-efficient method to address hypertension and related conditions caused by an overactive sympathetic nervous system. The company aims to meet the significant medical need for effective treatments for patients with poorly controlled hypertension.

Trice Medical, Inc. specializes in developing orthopedic diagnostic devices that incorporate camera-enabled technologies and needle-based systems. Founded in 2011 and based in Malvern, Pennsylvania, the company aims to enhance orthopedic diagnostics by providing instant and accurate visual insights for patients, physicians, and payors. Trice Medical's innovative products facilitate minimally invasive procedures that can be performed in an office setting, offering painless and cosmetically undetectable solutions for both diagnostic and therapeutic purposes. The company's technology addresses the shortcomings of traditional diagnostic methods, significantly reducing false readings and overall healthcare costs, while optimizing the delivery of patient care.

Trice Orthopedics, Inc. is based in King of Prussia, Pennsylvania, and specializes in camera-enabled needle technology designed for diagnostic and therapeutic procedures in orthopedics. The company aims to enhance orthopedic diagnostics and treatments by facilitating instant and accurate procedures in office settings. Trice's innovative technologies incorporate miniaturized opto-electronics into clinical solutions, providing immediate and definitive patient care. This approach addresses the limitations of traditional indirect modalities, reducing the risk of false readings while also lowering costs for the healthcare system through the use of existing reimbursement codes. The company's solutions are intended to benefit patients, physicians, and payers alike.

Angioslide, Ltd. is a medical device company established in 2005 and headquartered in Natanya, Israel, with additional subsidiaries in Karlsruhe, Germany, and Edina, Minnesota. The company specializes in developing innovative angioplasty products, notably the Angioslide eXtra balloon catheter, which serves both as a stand-alone balloon for angioplasty and as a device for debris removal. Its proprietary Embolic Capture Angioplasty™ technology allows physicians to capture and eliminate embolic particles, chronic thrombus, and atherosclerotic plaque debris during angioplasty procedures. Angioslide focuses on addressing the needs of various markets, including peripheral artery, lower limb artery, carotid, and coronary artery diseases.

Kona Medical, Inc. is a medical technology company based in Issaquah, Washington, founded in 2009 by Dr. Michael Gertner. The company specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. Its primary product, Surround Sound, is a hypertension therapy system that employs ultrasound imaging to precisely deliver focused ultrasound energy for renal denervation. This innovative approach targets the nerves associated with kidney function, offering a less invasive alternative for patients suffering from drug-resistant hypertension. By leveraging advancements in therapeutic focused ultrasound, Kona Medical seeks to improve treatment efficacy and reduce the health risks associated with high blood pressure.

Ablative Solutions, Inc. is a medical device company focused on developing innovative solutions for the treatment of hypertension. Founded in 2011 and headquartered in San Jose, California, with an additional office in Kalamazoo, Michigan, the company specializes in endovascular catheters, particularly the Peregrine System. This catheter allows for the minimally invasive delivery of therapeutic agents into the perivascular space surrounding peripheral blood vessels. Ablative Solutions offers an alternative to surgical renal denervation, providing a safe, effective, and cost-efficient method to address hypertension and related conditions caused by an overactive sympathetic nervous system. The company aims to meet the significant medical need for effective treatments for patients with poorly controlled hypertension.

Kona Medical, Inc. is a medical technology company based in Issaquah, Washington, founded in 2009 by Dr. Michael Gertner. The company specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. Its primary product, Surround Sound, is a hypertension therapy system that employs ultrasound imaging to precisely deliver focused ultrasound energy for renal denervation. This innovative approach targets the nerves associated with kidney function, offering a less invasive alternative for patients suffering from drug-resistant hypertension. By leveraging advancements in therapeutic focused ultrasound, Kona Medical seeks to improve treatment efficacy and reduce the health risks associated with high blood pressure.

CV Ingenuity, a Palo Alto, CA-based medical device company. CV Ingenuity Corp., a medical device company, develops devices for the treatment of vascular diseases to relieve vascular obstructions, inhibit restenosis, and allow natural vessel healing. It offers Drug Coated Balloon platform for the "Touch-and-Go" treatment of vascular disease. It was incorporated in 2008 and is based in Fremont, California. As of January 10, 2013, CV Ingenuity Corp. operates as a subsidiary of Covidien plc.

Ellipse Technologies is focused on developing its implantable remote control technology platforms to include innovative treatments for a broad spectrum of spinal and orthopedic deformity applications, orthopedic trauma and fracture management. The initial products restore proper anatomic position and alignment of the spine and long-bones. MAGECâ„¢ MAGnetic Expansion Control System utilizes a novel motion-preserving, minimally-invasive technology that, through communication with an external magnetic field, can be non-invasively adjusted in an outpatient setting via remote control by the physician to correct spinal deformities. PRECICE System uses non-invasive adjustable intramedullary rods or bone plates to treat long-bone abnormalities, often the result of acute or chronic fractures. Ellipse is a privately-held medical device company located in California.

Reverse Medical is a commercial-stage medical device company focused on revascularizing patients experiencing Acute Ischemic Stroke.

Embrella Cardiovascular, Inc. is a company based in Malvern, Pennsylvania, specializing in the development of a system designed to improve embolic cerebral protection. This innovative system aims to assist interventionalists in minimizing the occurrence of embolic strokes during cardiovascular procedures. By focusing on enhancing patient safety, Embrella Cardiovascular addresses a critical need in the healthcare sector, particularly in the realm of cardiovascular interventions.

Revascular Therapeutics is a medical device company that develops solutions for the intravascular treatment of complex lesions and total occlusions. Revascular develops percutaneous medical devices to reopen occluded vessels.

SynergEyes, Inc. is a technology-driven company specializing in the manufacture and sale of contact lenses for eye care professionals. Founded in 2001 and based in Carlsbad, California, SynergEyes focuses on hybrid contact lenses that combine the clarity of rigid gas permeable lenses with the comfort of soft lenses. Their product offerings cater to various eye conditions, including astigmatism, presbyopia, myopia, hyperopia, and keratoconus. By utilizing advanced high-Dk materials and vision-optimized designs, SynergEyes aims to enhance vision and quality of life for its patients. The company's products are distributed in the United States and internationally, addressing a recognized need for innovative lens solutions in the eye care industry.

AorTx, Inc. develops device solutions for percutaneous replacement of the aortic valve in the United States. Its devices cover the procedural solution for heart valve therapy from the implant to delivery and deployment of the valve. AorTx, Inc. was formerly known as CardiacMD, Inc. The company is based in Redwood City, California. As of November 15, 2007, AorTx, Inc. operates as a subsidiary of Hansen Medical, Inc.

Avantis Medical Systems, Inc. is a medical device company based in Sunnyvale, California, focused on developing catheter-based endoscopic devices aimed at detecting and treating cancers and other abnormalities in the gastrointestinal (GI) tract. The company leverages advanced technologies, including micro-chips and reinforced catheters, to create innovative solutions that enhance healthcare visualization and improve patient outcomes. With a team possessing extensive experience in the medical device industry, Avantis is dedicated to providing safe, cost-effective services that facilitate faster recovery for patients.

MiCardia is a privately held medical device company currently preparing for the commercialization of its first series of products, enCor™, in the European Union. enCor is a unique device that surgically treats mitral valve regurgitation. enCor utilizes the company's patented technology, Dynaplasty™, to provide a "second chance" to the patient who develops recurrent regurgitation. enCor can be activated to physiologically adjust the mitral valve leaflets to resolve regurgitation, minimally invasively, weeks to years later, without the need for the risk and cost of redo surgery.

Broncus Medical develops innovative diagnostic and therapeutic navigation technologies aimed at treating lung diseases. The company offers a range of products, including the Archimedes System, which features bronchoscopic trans-parenchymal needle access for virtual bronchoscopic planning and navigation, and the Lungpoint Virtual Bronchoscopic Navigation system that enables real-time navigation within the lungs for biopsy procedures. Additionally, Broncus is advancing its Exhale product line, which includes the Airway Bypass procedure, a minimally-invasive treatment for homogeneous emphysema, a prevalent form of the disease. The company is currently conducting the pivotal EASE Trial to evaluate this treatment. Founded in 1997 and originally named Broncus Technologies, the company is headquartered in San Jose, California, with additional operations in Shanghai, China, and Mountain View, California. Broncus Medical focuses on addressing the unmet medical needs in interventional pulmonology, improving the diagnosis and treatment of lung cancer and chronic obstructive pulmonary disease (COPD).

Avantis Medical Systems, Inc. is a medical device company based in Sunnyvale, California, focused on developing catheter-based endoscopic devices aimed at detecting and treating cancers and other abnormalities in the gastrointestinal (GI) tract. The company leverages advanced technologies, including micro-chips and reinforced catheters, to create innovative solutions that enhance healthcare visualization and improve patient outcomes. With a team possessing extensive experience in the medical device industry, Avantis is dedicated to providing safe, cost-effective services that facilitate faster recovery for patients.