MassVentures

Electrified Thermal Solutions is a company focused on decarbonizing industrial processes by replacing fossil fuels with renewable heat. Founded in 2021 and based in Medford, Massachusetts, the company originated from research conducted at MIT's Department of Nuclear Science and Engineering. Its innovative approach involves developing energy storage technology that converts intermittent renewable electricity into constant heat using low-cost conductive ceramic blocks. This technology enables various industrial sectors to utilize zero-carbon heat, contributing to a significant reduction in energy consumption's carbon footprint. Through its efforts, Electrified Thermal Solutions aims to facilitate an energy revolution that promotes sustainability in industrial applications.

Adden Energy is a company focused on the development of lithium-metal, solid-state batteries that offer significant advantages for electric vehicles. Their innovative technology is capable of achieving charge times as short as three minutes and maintaining capacity for over 10,000 cycles in lab-scale cells. By advancing solid-state battery technology, Adden Energy aims to facilitate the widespread adoption of electric vehicles globally, thereby playing a crucial role in promoting a cleaner and more sustainable future.

AeroShield specializes in the production of a super-insulating, nanoporous glass material designed for energy-efficient windows. This innovative material, made from silica aerogel, provides optical clarity akin to traditional glass while delivering insulation performance that is 50% superior to standard windows. By integrating AeroShield's technology between two glass panes, manufacturers can significantly enhance the thermal efficiency of their products. Additionally, the payback period for AeroShield-enhanced windows is up to five times faster than that of comparable high-performance windows, making it an attractive option for both manufacturers and consumers. This focus on sustainability and energy efficiency supports industry compliance goals and improves overall product performance.

Theromics Inc. is a biotechnology company focused on developing innovative cell therapies, particularly in the field of thermal ablation for cancer treatment. Founded in 2016 and based in West Bridgewater, Massachusetts, the company has created HeatSYNC Gel, a biopolymer thermal accelerant designed to enhance the effectiveness of microwave and radiofrequency ablation procedures. This gel improves the delivery and absorption of thermal energy in soft tissue and bone, optimizing the ablation zone's shape and volume. By increasing local tissue electrical conductivity, HeatSYNC Gel helps to prevent heat loss due to blood flow, allowing for more precise targeting of tumors and protecting surrounding healthy tissue. The gel can be administered through various methods, including syringe, laparoscope, and bronchoscope, and is intended to improve the overall efficacy of thermal ablation therapies while enabling personalized treatment approaches.

Electrified Thermal Solutions is a company focused on decarbonizing industrial processes by replacing fossil fuels with renewable heat. Founded in 2021 and based in Medford, Massachusetts, the company originated from research conducted at MIT's Department of Nuclear Science and Engineering. Its innovative approach involves developing energy storage technology that converts intermittent renewable electricity into constant heat using low-cost conductive ceramic blocks. This technology enables various industrial sectors to utilize zero-carbon heat, contributing to a significant reduction in energy consumption's carbon footprint. Through its efforts, Electrified Thermal Solutions aims to facilitate an energy revolution that promotes sustainability in industrial applications.

Versatope Therapeutics is a preclinical-stage biotechnology company specializing in immunotherapy. The company has developed a unique bacterial factory nanoparticle technology that allows for the display of multiple epitopes, addressing the challenges of strain-specific immunity. This innovative approach aims to enhance vaccine potency and improve therapeutic delivery. By enabling the creation of a single vaccine capable of protecting against multiple strains of influenza, Versatope seeks to provide solutions that can significantly advance vaccine development for biotechnology companies.

Gel4Med LLC is a Boston-based medical technology company established in 2015, specializing in the development of innovative biomaterials for tissue treatment and regeneration. The company focuses on creating an antimicrobial tissue-scaffolding matrix designed to eliminate antibiotic-resistant bacteria while promoting tissue regeneration. By utilizing bioinspired and engineered materials, Gel4Med aims to address significant healthcare challenges, particularly in wound care. Their leading technology employs a self-assembling peptide mechanism that acts as both an antibacterial barrier and a promoter of tissue regeneration, thus enhancing patient outcomes and preventing infections during surgical procedures.

Bloomer Tech, founded in 2015 and based in Cambridge, Massachusetts, is focused on enhancing women's health through innovative technology embedded in everyday clothing, specifically bras. The company develops fabric engineering technology that integrates biometric sensors to monitor vital health metrics, including electrocardiograms, pulse rates, respiratory rates, and heart rhythms. By leveraging machine learning and ordinary fabrics, Bloomer Tech creates a platform for personalized detection, monitoring, and treatment of chronic diseases, particularly those related to cardiovascular health. The collected data is analyzed and made accessible to users, healthcare providers, and medical professionals, fostering real-time healthcare solutions. Through its efforts, Bloomer Tech aims to build a comprehensive dataset on women’s heart health and contribute to addressing global cardiovascular health challenges.

Osmoses specializes in clean membrane technology aimed at decarbonizing gas separations, with a goal of eliminating one gigaton of carbon emissions annually. The company has developed advanced molecular filters that offer exceptional size selectivity, enabling the purification of hydrogen and natural gas. Additionally, these filters facilitate large-scale carbon capture, significantly transforming traditional chemical separation processes. By reducing energy consumption and carbon emissions in industrial operations, Osmoses provides a solution that helps businesses lower costs, minimize product loss, and create value for their clients, contributing to broader efforts in combating climate change.

PhagePro is an early-stage biotechnology therapeutics company focused on developing bacteriophage-based products aimed at preventing bacterial infections, particularly in vulnerable communities worldwide. By offering innovative alternatives for disease prevention, PhagePro seeks to control outbreaks in both clinical and community settings. Its products play a crucial role in addressing public health challenges, helping to prevent fatal diseases such as cholera and enhancing overall health outcomes.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Advanced Silicon Group is a nanotechnology company established in 2015, focused on commercializing innovative silicon nanotechnology developed by its employees. The company specializes in measuring host cell proteins in biomanufacturing, offering a range of technologies that include photovoltaics, lithium-ion batteries, microfluidics, and micro-electromechanical systems (MEMS). By leveraging silicon nanowire arrays, Advanced Silicon Group aims to enhance the performance of its clients' products while reducing costs, particularly through the development of next-generation biosensors that enable the simultaneous measurement of multiple protein concentrations.

EnVision Endoscopy specializes in developing medical devices for endoscopic surgeries, focusing on enhancing clinical outcomes for patients and efficiency for healthcare providers. The company's flagship product is an image-guided suturing system that attaches to standard flexible endoscopes, facilitating tissue approximation during surgical procedures. This biodegradable, single-use device simplifies various surgical tasks, making it more accessible for gastroenterologists and surgeons. By streamlining procedures, EnVision Endoscopy aims to reduce both procedure times and associated mortality rates, thereby improving overall patient care in the medical field.

Transcend Air is a company focused on the development and design of aircraft aimed at enhancing private air travel experiences. It specializes in vertical takeoff and landing (VTOL) aircraft, catering to commercial, private, and military sectors. In addition to manufacturing aircraft, Transcend Air operates a short-haul scheduled airline service that connects various cities, offering high-speed travel solutions for both passenger and military cargo transportation.

Guardion specializes in advanced sensor technology aimed at enhancing safety and security through innovative detection systems. The company has developed the world's first radiation detector that leverages the unique quantum properties of nanomaterials, resulting in low-cost, sensitive, and energy-efficient devices suitable for widespread deployment. Guardion's products include analytical instruments and portable chemical and radiation detectors, designed for use in challenging environments across various sectors, including aerospace, medical, and national security. Recognized for its contributions to technology and innovation, Guardion received the MassChallenge 2017 Gold Prize and the Technology in Space Prize from the Center for Advancement in Science in Space and Boeing. In early 2018, the company was selected for the inaugural cohort of the Techstars Autonomous Tech Accelerator, sponsored by the Air Force.

Notch Inc., located in Cambridge, Massachusetts, specializes in developing advanced metamaterial solutions that enhance antenna technology. The company's innovations enable electronically controlled beamforming, which improves communication ranges and performance. Additionally, Notch Inc. incorporates features that bolster cybersecurity, ensuring that their solutions not only optimize connectivity but also protect against potential threats. Through its cutting-edge technology, Notch Inc. aims to address the evolving needs of modern communication systems.

Emvolon is a technology company focused on developing a platform that facilitates the distributed production of chemicals from wasted resources, particularly natural gas at flare sites. By converting this wasted gas into usable chemicals, Emvolon addresses a variety of industrial applications and offers carbon-negative fuel alternatives. The company's innovative approach reimagines conventional diesel engines as miniature chemical reactors, allowing for efficient and localized chemical production. This method eliminates the need for large refineries and chemical plants, making it economically viable for smaller production facilities. Emvolon's technology aims to provide communities with the necessary raw materials while promoting sustainability and reducing waste.

BioSens8 is a developer of advanced biosensors designed to enhance health monitoring and prevent chronic diseases. The company's innovative platform offers real-time, quantitative biosensors that serve various applications. In healthcare, these biosensors assist women in assessing their fertility health, providing crucial information for family planning. In agriculture, BioSens8's technology enables farmers to manage herds effectively and optimize animal reproduction. Additionally, the biosensors can evaluate environmental health, contributing to the revitalization of fragile ecosystems. By catering to the healthcare, agriculture, military, and biomanufacturing sectors, BioSens8 aims to provide efficient solutions for holistic health monitoring.

Ortholevo develops joint injectable therapies that helps to cure tight, restrained joints.

Eyebot is a company focused on revolutionizing eye examination technology to enhance access to vision care. They have developed a freestanding self-service vision testing terminal that allows users to receive accurate eye prescriptions directly at the point of sale. This automated experience aims to reduce barriers to obtaining eye care, making it easier and more efficient for individuals to address their vision needs. By providing ophthalmologists with a proactive tool for eye examinations, Eyebot contributes to improved quality of life for patients while also facilitating cost savings within the healthcare system.

Cyvl.ai is a technology company focused on enhancing the management of physical infrastructure assets for civil engineers and government entities. Utilizing advanced 3D mapping technology and proprietary machine learning algorithms, Cyvl.ai provides a web-based software platform that enables users to efficiently gather and analyze data on various infrastructure elements such as roads, sidewalks, signs, and trees. Their vehicle-mounted mapping sensors streamline the process of infrastructure inspections, ultimately saving time and improving safety. The platform's capability for direct integration with other asset management tools further facilitates effective data utilization, making it a valuable resource for managing infrastructure assets more effectively and affordably.

Stata DX is a company based in Cambridge, Massachusetts, specializing in disease management technology. It has developed an innovative eRapid platform that facilitates at-home patient monitoring through custom biomarker panels for clinical studies. This platform employs a low-cost, affinity-based electrochemical sensing method capable of detecting a wide array of biomarkers in complex biological fluids, particularly liquid MRI for the brain. The technology allows for high sensitivity and selectivity, enabling researchers to gather real-time information about the composition of biological systems using just a single drop of blood.

BitEnergy AI is a technology company specializing in the development of advanced AI inference technology. This innovation consumes just one-tenth the energy of existing solutions, making it a more sustainable and cost-effective option for artificial intelligence applications. The company's offerings include novel neural network architectures, neuro-symbolic large models, and first-principle grounded tools. These enable clients to integrate their models with knowledge graphs and reasoning engines, leading to precise data retrieval, transparent decision-making, reduced AI costs, and streamlined processes.

Kytopen, established in 2017 and based in Cambridge, Massachusetts, specializes in the development of a cell therapy platform. This platform facilitates the non-viral delivery of molecules into challenging-to-transfect immune cells, making the process easier, faster, and more cost-effective. The company's proprietary Flowfect™ technology combines microfluidics and automation, enabling researchers to explore new biological discoveries and develop more affordable cell and gene therapies.

Feon develops new-molecule-based liquid electrolytes for lithium-ion and lithium-metal batteries.

River Otter Renewables is a recycling comany that produced biocrude oil from plant and waste as well as sewage and plastic waste.

Active Surfaces, a Massachusetts-based company, specializes in commercializing ultra-thin-film solar technology developed at MIT. Its core business involves creating flexible, lightweight solar panels that can be seamlessly integrated into everyday materials and surfaces, revolutionizing the conventional energy sector. The company's innovative manufacturing approach significantly reduces production costs, making solar power more accessible and affordable. This technology has the potential to transform semiconductor and electronics manufacturing, driving down costs for both module production and installation. By enabling virtually any surface to generate power, Active Surfaces aims to accelerate the transition to a cleaner, more sustainable future.

Western New England University, established in 1919, is a private, non-profit institution located in Springfield, Massachusetts. It offers a range of undergraduate and graduate programs, with notable strengths in Pharmacy and Engineering. The university is known for its small size, fostering a close-knit community where students can build relationships with professors and peers. It provides a comprehensive academic experience, with departments in Arts and Sciences, Business, and Engineering, along with a Pre-Pharmacy major leading to a graduate Pharmaceutical Sciences program. Additionally, it offers graduate degrees in Law, Engineering, and Business. The university enriches student life through various on-campus events, performing arts groups, and literary publications, as well as social activities and field trips. Admission requirements vary by program, and financial aid options are available to support tuition costs.

Dottir Labs specializes in developing spectroscopy sensor technology tailored for aqueous environments. This technology detects and measures nutrients, metabolic markers, and both organic and non-organic waste products in real-time, empowering clients to achieve sustainability through data-driven insights.

Benchmark Labs, based in San Francisco, California, specializes in AI-driven weather forecasting tailored for the agricultural sector and other industries. The company delivers precise, asset-specific forecasts that help clients navigate the challenges posed by changing weather patterns. By utilizing Internet of Things (IoT) sensors from various manufacturers, Benchmark Labs provides critical data that enables organizations to optimize renewable energy generation and manage water allocation effectively. The accuracy of their forecasts is essential for maintaining infrastructure and operational efficiency in the face of increasing weather variability.

Adhesion Technologies is a bio-adhesive producer offers an alternative to toxic furniture glues, promoting to reduce chemical exposure.

Blaze Power operates as a lithium-ion battery materials manufacturer. It innovates and commercializes iron-based cathode materials to enable mass-market electrification in transportation and energy storage. The company is driven to industrialize these cathodes in purpose-built inflation reduction act-compliant facilities.

ThermoBionics specializes in the production of wearable cooling goods that leverage innovative technology to enhance cooling efficiency while reducing weight. The company's proprietary, patent-pending technology effectively manages the body's thermoregulatory functions, allowing users to minimize sweating and facilitate moisture evaporation, regardless of external temperature and humidity conditions. This advancement provides a practical solution for individuals seeking comfort in varying environmental conditions.

MacroCycle Technologies is a company developing a chemical recycling process to convert polyethylene terephthalate (PET) and polyester-fiber waste into virgin-grade plastics. Their proprietary technology, based on synthesizing cyclic macromolecules, enables the production of recycled PET with lower energy use than traditional methods. This process offers a sustainable, zero-carbon, and cost-competitive solution for plastic upcycling, contributing to a circular economy.

Worcester Polytechnic Institute (WPI), located in Worcester, Massachusetts, is a prestigious technological university founded in 1865. Renowned for its commitment to project-based learning, WPI emphasizes practical application of theoretical knowledge to address real-world challenges. The university boasts a distinguished faculty and state-of-the-art research facilities, fostering an environment rich in innovation and collaboration. WPI attracts ambitious students eager to engage in hands-on experiences that prepare them to make meaningful contributions to society. With a strong focus on developing skills that are crucial in today’s dynamic landscape, WPI positions itself as a leader in education and research, dedicated to empowering its students and faculty to achieve excellence.

EnVision Endoscopy specializes in developing medical devices for endoscopic surgeries, focusing on enhancing clinical outcomes for patients and efficiency for healthcare providers. The company's flagship product is an image-guided suturing system that attaches to standard flexible endoscopes, facilitating tissue approximation during surgical procedures. This biodegradable, single-use device simplifies various surgical tasks, making it more accessible for gastroenterologists and surgeons. By streamlining procedures, EnVision Endoscopy aims to reduce both procedure times and associated mortality rates, thereby improving overall patient care in the medical field.

Aclarity, LLC is a cleantech startup established in 2017 and based in the United States. The company specializes in manufacturing and marketing advanced water purification devices designed for residential use. Aclarity's systems utilize innovative electrochemical technology to effectively eliminate a wide range of contaminants, including pathogens, metals, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFAS), and ammonia from water. These devices provide customers with cost-effective and low-maintenance solutions for comprehensive water treatment, addressing the pressing need for clean water in homes and contributing to broader environmental sustainability efforts.

AeroShield specializes in the production of a super-insulating, nanoporous glass material designed for energy-efficient windows. This innovative material, made from silica aerogel, provides optical clarity akin to traditional glass while delivering insulation performance that is 50% superior to standard windows. By integrating AeroShield's technology between two glass panes, manufacturers can significantly enhance the thermal efficiency of their products. Additionally, the payback period for AeroShield-enhanced windows is up to five times faster than that of comparable high-performance windows, making it an attractive option for both manufacturers and consumers. This focus on sustainability and energy efficiency supports industry compliance goals and improves overall product performance.

Emvolon is a technology company focused on developing a platform that facilitates the distributed production of chemicals from wasted resources, particularly natural gas at flare sites. By converting this wasted gas into usable chemicals, Emvolon addresses a variety of industrial applications and offers carbon-negative fuel alternatives. The company's innovative approach reimagines conventional diesel engines as miniature chemical reactors, allowing for efficient and localized chemical production. This method eliminates the need for large refineries and chemical plants, making it economically viable for smaller production facilities. Emvolon's technology aims to provide communities with the necessary raw materials while promoting sustainability and reducing waste.

Florrent is a bio-based materials and energy storage company focused on addressing key challenges in global decarbonization and the electrification of transportation and buildings. It specializes in the development of energy-density ultracapacitors made from sustainable hemp biomass sourced from a network of BIPOC farmers. These ultracapacitors enhance the stability of electrical grids and facilitate the integration of renewable energy sources, electric vehicles, and net-zero buildings. By enabling communities to locally generate, store, and utilize renewable power, Florrent contributes to the transition towards a resilient, renewable, and equitable energy economy.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Southie Autonomy is a Boston-based company founded in 2017 that specializes in developing robot software allowing industrial robots to be easily re-purposed and re-deployed by individuals without robotics expertise or technical skills. The company's automation system facilitates quick setup and execution of new robotic tasks, making it feasible for businesses to justify the use of automation in a wider range of applications, such as kitting, palletizing, and simple assembly. By lowering the time, cost, and skill barriers associated with robotic automation, Southie Autonomy aims to help businesses achieve a faster return on investment.

Phoenix Tailings Inc. is a Massachusetts-based company that focuses on the recycling and re-mining of mining tailings and hazardous by-products, such as Bauxite Residue, to produce essential metal products. Founded in 2019, the company aims to extract strategic materials critical to various industries, including aerospace, defense, automotive, biotechnology, and electronics. By treating mining and refining waste as new ore, Phoenix Tailings provides an innovative solution to eliminate hazardous environmental waste while creating primary metals sustainably and economically. This approach not only addresses the demand for metals in multiple sectors but also promotes environmentally friendly practices by offering carbon-free alternatives.

Fourier is a thermal management solutions ranging from high power density electronics to renewable energy to space applications.

Rendever is a company focused on addressing social isolation among seniors through virtual reality experiences. Its platform is utilized in senior living communities and healthcare settings to alleviate feelings of depression and loneliness by promoting personal connections. Participants can engage in group sessions to fulfill bucket list items, revisit significant locations, and share stories, thereby enhancing their emotional well-being. Rendever collaborates with notable senior living operators and healthcare systems, and its initiatives are supported by research from organizations such as the NIH and NIA. The company also has commercial partnerships with prominent entities, including AARP and Verizon, to expand its reach and impact.

Notch Inc., located in Cambridge, Massachusetts, specializes in developing advanced metamaterial solutions that enhance antenna technology. The company's innovations enable electronically controlled beamforming, which improves communication ranges and performance. Additionally, Notch Inc. incorporates features that bolster cybersecurity, ensuring that their solutions not only optimize connectivity but also protect against potential threats. Through its cutting-edge technology, Notch Inc. aims to address the evolving needs of modern communication systems.

Feon develops new-molecule-based liquid electrolytes for lithium-ion and lithium-metal batteries.

AmberGen, Inc. is a privately-held company based in the Boston area, established in 1995 to commercialize innovative photonic technology originally developed at Boston University. The company focuses on advancing therapeutics and diagnostics by addressing significant challenges in medicine. AmberGen employs patented techniques in proteomics and utilizes light-based control of biomolecules to create photocleavable linkers and protein engineering reagents. Its services encompass drug discovery, the development of high-throughput multiplex immuno-diagnostic assays, and mass spectrometric imaging for advanced tissue and array scanning. These innovations enable medical practitioners to detect diseases at earlier stages, thereby enhancing diagnostic capabilities and improving patient outcomes.

Reveal Pharmaceuticals focuses on developing innovative MRI contrast agents that provide a gadolinium-free alternative to existing gadolinium-based contrast agents (GBCAs). The company aims to enhance medical imaging safety for all patients, particularly those at risk from gadolinium exposure. Its pipeline includes precision imaging agents designed to assist in the diagnosis and treatment of conditions such as pulmonary embolism and cancer. By integrating its patented gadolinium-free RVP platform with targeted molecular probes, Reveal Pharmaceuticals enables healthcare professionals to conduct safer scans without the need for biopsies, thereby supporting the advancement of targeted therapeutics and personalized medicine.

Kanda Industries designs and manufactures the custom furnitures for homes and Offices.

Irradiant Technologies, founded in 2020 and based in Cambridge, Massachusetts, specializes in advanced nanofabrication utilizing implosion fabrication lithography. The company focuses on developing a platform that facilitates the ultrafast three-dimensional assembly of mixed materials, such as conductors, semiconductors, dielectrics, proteins, and DNA, with nanoscale precision and gradient control. This innovative approach enables the creation of novel photonic and optical components, providing light-based alternatives for applications in telecommunications, computation, and sensing.

Advanced Silicon Group is a nanotechnology company established in 2015, focused on commercializing innovative silicon nanotechnology developed by its employees. The company specializes in measuring host cell proteins in biomanufacturing, offering a range of technologies that include photovoltaics, lithium-ion batteries, microfluidics, and micro-electromechanical systems (MEMS). By leveraging silicon nanowire arrays, Advanced Silicon Group aims to enhance the performance of its clients' products while reducing costs, particularly through the development of next-generation biosensors that enable the simultaneous measurement of multiple protein concentrations.

EnVision Endoscopy specializes in developing medical devices for endoscopic surgeries, focusing on enhancing clinical outcomes for patients and efficiency for healthcare providers. The company's flagship product is an image-guided suturing system that attaches to standard flexible endoscopes, facilitating tissue approximation during surgical procedures. This biodegradable, single-use device simplifies various surgical tasks, making it more accessible for gastroenterologists and surgeons. By streamlining procedures, EnVision Endoscopy aims to reduce both procedure times and associated mortality rates, thereby improving overall patient care in the medical field.

Haystack Ag supports growers and global carbon markets with tools for high-accuracy, cost-effective soil carbon measurement.

Seia Bio is a biotechnology company that specializes in the development and production of non-model microbes. These are beneficial microorganisms that are not typically studied in laboratories but play crucial roles in various industries, such as agriculture. Seia Bio's core business involves enhancing the shelf-life and temperature stability of these non-model microbes through a proprietary coating technology. This process protects the microbes from harsh environmental conditions, ensuring their viability and effectiveness. By doing so, Seia Bio aims to improve the yield and sustainability of crops, ultimately benefiting farmers and the agricultural industry.

AI platform producing compostable and biodegradable plastic alternatives

Northeastern University, founded in 1898, is a private, research-intensive university located in Boston, Massachusetts. It offers a wide range of undergraduate and graduate programs, including doctorate degrees, across nine colleges and schools. Additionally, it provides select advanced degrees at graduate campuses in Charlotte, North Carolina, and Seattle. The university is renowned for its experiential learning approach, integrating real-world experience into its academic curriculum.

Aclarity, LLC is a cleantech startup established in 2017 and based in the United States. The company specializes in manufacturing and marketing advanced water purification devices designed for residential use. Aclarity's systems utilize innovative electrochemical technology to effectively eliminate a wide range of contaminants, including pathogens, metals, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFAS), and ammonia from water. These devices provide customers with cost-effective and low-maintenance solutions for comprehensive water treatment, addressing the pressing need for clean water in homes and contributing to broader environmental sustainability efforts.

Osmoses specializes in clean membrane technology aimed at decarbonizing gas separations, with a goal of eliminating one gigaton of carbon emissions annually. The company has developed advanced molecular filters that offer exceptional size selectivity, enabling the purification of hydrogen and natural gas. Additionally, these filters facilitate large-scale carbon capture, significantly transforming traditional chemical separation processes. By reducing energy consumption and carbon emissions in industrial operations, Osmoses provides a solution that helps businesses lower costs, minimize product loss, and create value for their clients, contributing to broader efforts in combating climate change.

Stitch3D is a cloud platform designed for hosting, viewing, analyzing, and sharing 3D files. The company focuses on streamlining the process of translating complex spatial data into actionable insights, significantly reducing the time required for such tasks. By utilizing artificial intelligence and machine learning algorithms, Stitch3D enables differential analysis, feature extraction, geometric search, and predictive maintenance. This technology allows enterprises to collect, aggregate, and manage 3D data in a more simplified and accessible manner.

Gel4Med LLC is a Boston-based medical technology company established in 2015, specializing in the development of innovative biomaterials for tissue treatment and regeneration. The company focuses on creating an antimicrobial tissue-scaffolding matrix designed to eliminate antibiotic-resistant bacteria while promoting tissue regeneration. By utilizing bioinspired and engineered materials, Gel4Med aims to address significant healthcare challenges, particularly in wound care. Their leading technology employs a self-assembling peptide mechanism that acts as both an antibacterial barrier and a promoter of tissue regeneration, thus enhancing patient outcomes and preventing infections during surgical procedures.

Loop CO2 is a company focused on developing innovative technology that transforms carbon dioxide into essential products, contributing to a sustainable future. By converting CO2 into items such as cosmetic oils, adhesives, and thermoplastic elastomers, Loop CO2 enables its customers to minimize their environmental impact through the use of eco-friendly alternatives. The company's solutions aim to address climate challenges while promoting the utilization of carbon emissions in a productive manner.

Z-Polymers is a clean-tech materials science company based in Lowell, Massachusetts, founded in 2021. It focuses on developing innovative polymer materials, particularly thin fiber polymers, to address fundamental challenges in mission-critical industries. The company's applications span areas such as 3D printing and the hydrogen economy, where it strives to enhance sustainability and environmental safety by replacing toxic substances with eco-friendly alternatives. Through its advanced polymer science, Z-Polymers aims to contribute to the development of sustainable solutions that support various industrial needs.

PathMaker Neurosystems is a neurotechnology company focused on developing non-invasive treatments for serious neurological disorders, particularly neuromotor conditions. The company is advancing a platform that employs neuronal hyperexcitability suppression, utilizing a multi-site, precision-targeted neuromodulatory approach. Initially, PathMaker is applying this innovative technology to address issues related to stroke and amyotrophic lateral sclerosis (ALS). They are in the process of manufacturing a non-invasive device specifically designed to treat post-stroke spasticity. This novel approach enables the regulation of motor neuron excitability, allowing patients to receive effective treatment without the need for drugs or surgery.

Electrified Thermal Solutions is a company focused on decarbonizing industrial processes by replacing fossil fuels with renewable heat. Founded in 2021 and based in Medford, Massachusetts, the company originated from research conducted at MIT's Department of Nuclear Science and Engineering. Its innovative approach involves developing energy storage technology that converts intermittent renewable electricity into constant heat using low-cost conductive ceramic blocks. This technology enables various industrial sectors to utilize zero-carbon heat, contributing to a significant reduction in energy consumption's carbon footprint. Through its efforts, Electrified Thermal Solutions aims to facilitate an energy revolution that promotes sustainability in industrial applications.

AeroShield specializes in the production of a super-insulating, nanoporous glass material designed for energy-efficient windows. This innovative material, made from silica aerogel, provides optical clarity akin to traditional glass while delivering insulation performance that is 50% superior to standard windows. By integrating AeroShield's technology between two glass panes, manufacturers can significantly enhance the thermal efficiency of their products. Additionally, the payback period for AeroShield-enhanced windows is up to five times faster than that of comparable high-performance windows, making it an attractive option for both manufacturers and consumers. This focus on sustainability and energy efficiency supports industry compliance goals and improves overall product performance.

Eden is focused on developing a sustainable platform for natural resource recovery, aiming to create a carbon-neutral future. The company has introduced a novel method known as Pulsed Electrical Well Stimulation (PEWS), which is a patent-pending technology designed to replace traditional hydraulic fracturing. This innovative approach eliminates the need for water injection and addresses the logistical challenges and environmental risks associated with conventional fracking methods. By utilizing high-voltage electricity and proprietary modeling techniques, Eden enhances rock permeability with precision, facilitating effective resource extraction across various geological settings. This technology not only reduces costs but also minimizes the negative impacts typically associated with hydraulic fracturing, positioning Eden as a leader in environmentally responsible resource recovery.

Atlantic Quantum is a company focused on developing scalable quantum computers to address complex computational challenges. Founded in 2022, the company emphasizes the importance of fault-tolerant quantum hardware as essential for advancing the field of quantum computing. By creating reliable and efficient quantum systems, Atlantic Quantum aims to enable engineers and researchers to make significant strides in solving difficult problems that traditional computing methods struggle to address.

Florrent is a bio-based materials and energy storage company focused on addressing key challenges in global decarbonization and the electrification of transportation and buildings. It specializes in the development of energy-density ultracapacitors made from sustainable hemp biomass sourced from a network of BIPOC farmers. These ultracapacitors enhance the stability of electrical grids and facilitate the integration of renewable energy sources, electric vehicles, and net-zero buildings. By enabling communities to locally generate, store, and utilize renewable power, Florrent contributes to the transition towards a resilient, renewable, and equitable energy economy.

Talking Heads Wireless is a telecommunication company that helps in energy savings for cellular networks.

The University of Massachusetts Amherst is a public research and land-grant university that offers undergraduate, master's, and doctoral programs. It serves as the flagship campus of the University of Massachusetts system. The university has multiple academic departments and research facilities that support a range of disciplines.

Aloft Systems specializes in maritime transportation by developing innovative wind propulsion technology aimed at enhancing the efficiency of existing vessels. The company focuses on creating self-contained wind propulsion units that can be integrated into ships, allowing for autonomous operation. This technology significantly reduces emissions and eliminates fuel costs, making it accessible for a wide range of vessels. By enabling shipping companies to utilize direct wind propulsion, Aloft Systems enhances cargo transportation on point-to-point routes, thereby improving delivery reliability and contributing to a more sustainable maritime industry.

Arrakis Materials converts CO₂ into carbon-negative minerals, enabling carbon storage and utilization.

Prisere LLC is a resilience consulting firm that specializes in helping businesses worldwide navigate and mitigate risks, particularly those related to climate change and disasters. The company offers a range of services, including risk communications, mapping, and software applications, along with training and technical advisory services. By leveraging partnerships with various institutions, Prisere aims to enhance clients' resilience, improve risk management, and facilitate access to affordable insurance, ultimately bolstering their long-term profitability and stability.

Stepwise specializes in home electrification services, focusing on the installation of electric vehicle (EV) chargers and heat pumps. The company has developed a software-defined smart device that connects to an electric panel, acting as an intermediary between the panel and the EV charger. This device monitors energy consumption and manages the charger, ensuring efficient and reliable charging services for clients. By leveraging this technology, Stepwise aims to enhance the accessibility and effectiveness of home electrification solutions.

Lithios is a technology company specializing in advanced lithium extraction through innovative electrochemical methods. The firm focuses on capturing and releasing lithium from complex mixtures, which are traditionally challenging to process. By leveraging breakthroughs in applied electrochemistry, Lithios offers solutions that facilitate low-cost and selective extraction of lithium from previously untapped brine resources. This approach not only enhances the efficiency of lithium recovery but also aligns with sustainable practices, supporting the growing demand for lithium in various industries, particularly in the context of an electric future.

Carbix is a company focused on converting atmospheric carbon dioxide into carbonates, which serve as raw materials for various industrial products. Utilizing innovative bioreactor technology, Carbix captures CO2 from industrial flue gas and rapidly transforms it, along with mineral inputs, into usable raw materials within hours. The company employs advanced weathering techniques powered by renewable energy or energy-from-waste, enhancing the sequestration of CO2 emissions. This process not only helps mitigate climate change by reducing atmospheric carbon but also enables businesses to source industrial materials sustainably.

InGel Therapeutics is a Cambridge, Massachusetts-based company founded in 2021 that focuses on developing stem cell therapeutics and biodegradable polymers. The company specializes in engineered cell therapy aimed at addressing neuroprotective pathways to treat retinal degeneration. By utilizing stem cells and their secretome, InGel Therapeutics seeks to provide neuroprotection for blinding diseases such as retinitis pigmentosa and macular degeneration. Their innovative approach involves using biodegradable polymers to isolate proteins of neuroprotective significance, first in vitro and subsequently in vivo, thereby enabling healthcare professionals to effectively treat patients suffering from retinal degeneration.

Jetcool Technologies Inc., established in 2019 and headquartered in Littleton, Massachusetts, specializes in the research and development of advanced cooling solutions for high-power electronics. The company's core product, microjet cooling modules, is designed to efficiently cool components at the chip or device level, serving industries such as defense and aerospace, advanced semiconductors, data centers, and electric vehicle power systems. Jetcool's technology, developed at MIT Lincoln Laboratory, offers customized and stock products, targeting long-lasting, low-heat, and power-efficient devices.

AeroShield specializes in the production of a super-insulating, nanoporous glass material designed for energy-efficient windows. This innovative material, made from silica aerogel, provides optical clarity akin to traditional glass while delivering insulation performance that is 50% superior to standard windows. By integrating AeroShield's technology between two glass panes, manufacturers can significantly enhance the thermal efficiency of their products. Additionally, the payback period for AeroShield-enhanced windows is up to five times faster than that of comparable high-performance windows, making it an attractive option for both manufacturers and consumers. This focus on sustainability and energy efficiency supports industry compliance goals and improves overall product performance.

AeroShield specializes in the production of a super-insulating, nanoporous glass material designed for energy-efficient windows. This innovative material, made from silica aerogel, provides optical clarity akin to traditional glass while delivering insulation performance that is 50% superior to standard windows. By integrating AeroShield's technology between two glass panes, manufacturers can significantly enhance the thermal efficiency of their products. Additionally, the payback period for AeroShield-enhanced windows is up to five times faster than that of comparable high-performance windows, making it an attractive option for both manufacturers and consumers. This focus on sustainability and energy efficiency supports industry compliance goals and improves overall product performance.

Harmony is a biotechnology startup that creates human breast milk protein-based infant nutrition designed to help human babies thrive. It is the world’s first dairy-free, allergen-free and environmentally friendly infant nutrition. Harmony Baby Nutrition was established in 2018 and is based in Boston, MA.

Leuko Labs, Inc., established in 2017 and headquartered in Boston, Massachusetts, specializes in developing healthcare equipment for non-invasive monitoring of white blood cells. Their flagship product, PointCheck, enables frequent testing of immunosuppressed patients, such as those undergoing chemotherapy, without the need for blood draws or laboratory infrastructure. This innovation aims to enhance patients' quality of life and improve clinical outcomes by facilitating early detection of life-threatening infections and personalized chemotherapy management.

Cyvl.ai is a technology company focused on enhancing the management of physical infrastructure assets for civil engineers and government entities. Utilizing advanced 3D mapping technology and proprietary machine learning algorithms, Cyvl.ai provides a web-based software platform that enables users to efficiently gather and analyze data on various infrastructure elements such as roads, sidewalks, signs, and trees. Their vehicle-mounted mapping sensors streamline the process of infrastructure inspections, ultimately saving time and improving safety. The platform's capability for direct integration with other asset management tools further facilitates effective data utilization, making it a valuable resource for managing infrastructure assets more effectively and affordably.

Kinto.Care is an online platform designed to enhance communication and support for caregivers, particularly those caring for loved ones with dementia. The platform offers user-generated content and digital tools that facilitate care team collaboration, medication management, and tracking of health data. By providing practical advice, care planning, and group learning opportunities, Kinto.Care aims to empower family members to effectively coordinate care and manage their loved ones' medical needs through a unified interface.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Pison Technology, Inc., established in 2016 and headquartered in Boston, Massachusetts, specializes in developing and marketing wearable devices. These devices are designed to capture and filter signals sent to the nervous system, primarily serving individuals with amyotrophic lateral sclerosis (ALS). Pison's innovative, non-invasive electroneurography (ENG) algorithms and sensor array technology aim to optimize cognitive and physiological capabilities through gesture control, with applications in cognitive enhancement, disease diagnosis, and improving overall quality of life.

Reveal Pharmaceuticals focuses on developing innovative MRI contrast agents that provide a gadolinium-free alternative to existing gadolinium-based contrast agents (GBCAs). The company aims to enhance medical imaging safety for all patients, particularly those at risk from gadolinium exposure. Its pipeline includes precision imaging agents designed to assist in the diagnosis and treatment of conditions such as pulmonary embolism and cancer. By integrating its patented gadolinium-free RVP platform with targeted molecular probes, Reveal Pharmaceuticals enables healthcare professionals to conduct safer scans without the need for biopsies, thereby supporting the advancement of targeted therapeutics and personalized medicine.

EnVision Endoscopy specializes in developing medical devices for endoscopic surgeries, focusing on enhancing clinical outcomes for patients and efficiency for healthcare providers. The company's flagship product is an image-guided suturing system that attaches to standard flexible endoscopes, facilitating tissue approximation during surgical procedures. This biodegradable, single-use device simplifies various surgical tasks, making it more accessible for gastroenterologists and surgeons. By streamlining procedures, EnVision Endoscopy aims to reduce both procedure times and associated mortality rates, thereby improving overall patient care in the medical field.

Eden is focused on developing a sustainable platform for natural resource recovery, aiming to create a carbon-neutral future. The company has introduced a novel method known as Pulsed Electrical Well Stimulation (PEWS), which is a patent-pending technology designed to replace traditional hydraulic fracturing. This innovative approach eliminates the need for water injection and addresses the logistical challenges and environmental risks associated with conventional fracking methods. By utilizing high-voltage electricity and proprietary modeling techniques, Eden enhances rock permeability with precision, facilitating effective resource extraction across various geological settings. This technology not only reduces costs but also minimizes the negative impacts typically associated with hydraulic fracturing, positioning Eden as a leader in environmentally responsible resource recovery.

Radical Plastics, Inc., based in Winchester, Massachusetts, develops biodegradable plastic compounds designed to address plastic pollution. Incorporated in 2018, the company utilizes a proprietary, naturally occurring catalyst to blend with conventional plastics, making them fully biodegradable in the natural environment. Their innovative technology offers soil degradable compounds specifically for agricultural film, providing an economically viable solution for brands seeking drop-in replacements for traditional plastics. Through its commitment to sustainability, Radical Plastics aims to contribute to reducing plastic waste and promoting environmental health.

Gradient is a developer of secure software that addresses fundamental issues of trust and authenticity in the digital landscape. The company's solutions focus on redefining identity and data authentication, providing a framework for establishing trust and facilitating the sharing of provable statements while ensuring privacy and security. This enables users to collaborate openly without sacrificing digital security or integrity. Gradient's infrastructure is designed to foster decentralized trust, contributing to safer and more reliable digital interactions.

Jaxon.AI is an artificial intelligence platform designed to assist data science teams throughout the research, design, and build process. By leveraging technologies such as ChatGPT, Jaxon addresses complex, use case-specific challenges and creates detailed blueprints that guide users in adhering to optimal development paths. Its proprietary reasoning engine simulates model performance to evaluate trade-offs, allowing teams to identify the most effective solutions for their projects. This structured approach enhances the likelihood of success in AI initiatives, streamlining the design cycle and ensuring that users can navigate the complexities of AI development effectively.

Leuko Labs, Inc., established in 2017 and headquartered in Boston, Massachusetts, specializes in developing healthcare equipment for non-invasive monitoring of white blood cells. Their flagship product, PointCheck, enables frequent testing of immunosuppressed patients, such as those undergoing chemotherapy, without the need for blood draws or laboratory infrastructure. This innovation aims to enhance patients' quality of life and improve clinical outcomes by facilitating early detection of life-threatening infections and personalized chemotherapy management.

Extend Biosciences Inc. is an emerging biotechnology company developing a novel drug delivery platform technology that improves the pharmacokinetic properties of peptides and proteins. Peptides have been particularly challenging to bring to market because they are removed from circulation prior to administering therapeutic value. Their proprietary platform technology significantly improves the circulating half-life and bioavailability of peptides and proteins, enabling the scientific community to truly develop potent and specific drugs. Their mission is to revolutionize drug delivery and give patients a better quality of life.

AmberGen, Inc. is a privately-held company based in the Boston area, established in 1995 to commercialize innovative photonic technology originally developed at Boston University. The company focuses on advancing therapeutics and diagnostics by addressing significant challenges in medicine. AmberGen employs patented techniques in proteomics and utilizes light-based control of biomolecules to create photocleavable linkers and protein engineering reagents. Its services encompass drug discovery, the development of high-throughput multiplex immuno-diagnostic assays, and mass spectrometric imaging for advanced tissue and array scanning. These innovations enable medical practitioners to detect diseases at earlier stages, thereby enhancing diagnostic capabilities and improving patient outcomes.

Mesodyne is an engineering and manufacturing company focused on innovative electricity generation solutions, particularly through its patented LightCell technology, which converts various fuels into electricity using light. Founded in 2018 by Drs. Veronika Stelmakh and Walker Chan, the company aims to deliver portable and reliable power generation systems to military and commercial users. Mesodyne's compact power generators enhance the endurance of small autonomous systems, offering efficient and long-lasting energy sources that bridge the gap between traditional batteries and internal combustion engines. This technology is designed to alleviate the burden on dismounted warfighters and emergency responders while extending the operational range of unmanned vehicles, wearables, and other equipment.

Aclarity, LLC is a cleantech startup established in 2017 and based in the United States. The company specializes in manufacturing and marketing advanced water purification devices designed for residential use. Aclarity's systems utilize innovative electrochemical technology to effectively eliminate a wide range of contaminants, including pathogens, metals, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFAS), and ammonia from water. These devices provide customers with cost-effective and low-maintenance solutions for comprehensive water treatment, addressing the pressing need for clean water in homes and contributing to broader environmental sustainability efforts.

The principal mission of the Company is to provide technology and technology services to industry and public sector agencies for enhanced productivity, improved safety, and reduced costs.

PathMaker Neurosystems is a neurotechnology company focused on developing non-invasive treatments for serious neurological disorders, particularly neuromotor conditions. The company is advancing a platform that employs neuronal hyperexcitability suppression, utilizing a multi-site, precision-targeted neuromodulatory approach. Initially, PathMaker is applying this innovative technology to address issues related to stroke and amyotrophic lateral sclerosis (ALS). They are in the process of manufacturing a non-invasive device specifically designed to treat post-stroke spasticity. This novel approach enables the regulation of motor neuron excitability, allowing patients to receive effective treatment without the need for drugs or surgery.