MassVentures

Electrified Thermal Solutions is a Massachusetts-based company founded in 2021 that focuses on decarbonizing industrial processes by replacing fossil fuels with renewable heat. Originating from research at MIT's Department of Nuclear Science and Engineering, the company has developed innovative energy storage technology that converts intermittent renewable electricity into constant heat. This is achieved through the use of low-cost conductive ceramic blocks, allowing various industrial sectors to utilize zero-carbon heat effectively. By providing a sustainable alternative for furnaces, turbines, boilers, and kilns, Electrified Thermal Solutions aims to drive an energy revolution and significantly reduce carbon emissions in industry.

Adden Energy specializes in developing advanced lithium-metal, solid-state battery technologies. With proven rapid charge capabilities (as low as 3 minutes) and exceptional cycle life (over 10,000 cycles), the company aims to accelerate electric vehicle adoption globally, contributing significantly to a cleaner energy future.

AeroShield specializes in the production of super-insulating, nanoporous glass materials designed for energy-efficient windows. Utilizing silica aerogel, AeroShield's products offer optical clarity akin to traditional glass while delivering superior insulation, making them 50% more effective than conventional double-pane windows. This innovative approach not only enhances thermal comfort but also significantly improves energy performance, allowing window manufacturers to meet sustainability and compliance objectives. Additionally, the payback period for AeroShield's materials is up to five times faster than that of similarly performing windows, making them a compelling choice for the modern market.

Theromics Inc., founded in 2016, develops innovative cell therapies. It specializes in HeatSYNC Gel, a biopolymer thermal accelerant that enhances microwave and radiofrequency energy absorption during soft tissue ablation procedures. This gel amplifies heat movement, optimizes ablation zone shape, increases treatment area, and protects critical tissues.

Electrified Thermal Solutions is a Massachusetts-based company founded in 2021 that focuses on decarbonizing industrial processes by replacing fossil fuels with renewable heat. Originating from research at MIT's Department of Nuclear Science and Engineering, the company has developed innovative energy storage technology that converts intermittent renewable electricity into constant heat. This is achieved through the use of low-cost conductive ceramic blocks, allowing various industrial sectors to utilize zero-carbon heat effectively. By providing a sustainable alternative for furnaces, turbines, boilers, and kilns, Electrified Thermal Solutions aims to drive an energy revolution and significantly reduce carbon emissions in industry.

Versatope Therapeutics is a preclinical-stage biotechnology company that specializes in immuno-therapeutics aimed at enhancing vaccine potency and therapeutic delivery. The company has developed a proprietary bacterial factory nanoparticle technology that allows for the display of multiple epitopes. This innovative approach is designed to address challenges associated with strain-specific immunity, enabling the creation of a single vaccine capable of providing protection against multiple strains of influenza. By focusing on these advancements, Versatope aims to support biotechnology companies in their efforts to develop more effective vaccines.

Gel4Med LLC is a Boston-based medical technology company founded in 2015, specializing in the development of innovative biomaterials for tissue treatment and regeneration. The company focuses on creating an antimicrobial tissue-scaffolding matrix that addresses the challenge of antibiotic-resistant bacteria while facilitating tissue regeneration. Utilizing bioinspired and engineering approaches, Gel4Med's technology aims to improve patient outcomes in various therapeutic areas, particularly in wound care and tissue regeneration. Their leading asset features a self-assembling peptide technology that acts as both an antibacterial barrier and a promoter of tissue regeneration, enabling patients to prevent infections during surgical procedures.

Bloomer Tech is a company that designs and manufactures bras embedded with advanced fabric engineering technology to monitor women's cardiovascular health. Founded in 2015 and based in Cambridge, Massachusetts, the company utilizes everyday fabrics and machine learning to collect critical health metrics, including electrocardiograms, pulse rates, respiratory rates, and heart rhythms. By integrating biometric sensors into its products, Bloomer Tech aims to create a reliable data set that enhances understanding of women's heart health and supports personalized healthcare solutions. The company's innovative approach enables real-time access to meaningful health data for users and healthcare professionals, facilitating improved monitoring and treatment of chronic diseases. The founders of Bloomer Tech, Aceil Halaby, Alicia Chong Rodriguez, and Monica Abarca, are committed to addressing global cardiovascular health challenges through their technology.

Osmoses is a company focused on decarbonizing gas separations to significantly reduce carbon emissions, aiming to eliminate one gigaton of carbon emissions annually. It operates a clean membrane technology system designed to lower energy consumption and carbon emissions in industrial processes. The company's molecular filters are specifically engineered for exceptional size selectivity, allowing them to purify hydrogen and natural gas effectively while also enabling large-scale carbon capture. By transforming chemical separations, Osmoses helps industrial clients reduce costs and product loss, ultimately generating value and contributing to climate change mitigation efforts.

PhagePro is an early-stage biotechnology company developing bacteriophage-based products to combat global health disparities and antibiotic resistance. Its lead program focuses on treating cholera, with a commitment to affordable and locally adaptable healthcare solutions through collaboration with stakeholders.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Advanced Silicon Group is a nanotechnology company founded in 2015, focused on commercializing innovative silicon nanotechnology developed by its employees. The company specializes in measuring host cell proteins in biomanufacturing, utilizing its advanced technology to enhance various applications, including photovoltaics, lithium-ion batteries, microfluidics, and micro-electromechanical systems (MEMS). Advanced Silicon Group is also engaged in the development of next-generation biosensors, leveraging silicon to enable multiplexed measurements that allow for the simultaneous detection of multiple protein concentrations. This capability aids clients in improving performance and reducing costs by integrating silicon nanowire arrays into their products.

EnVision Endoscopy specializes in developing innovative medical devices aimed at enhancing endoscopic surgical procedures. Their flagship product is an image-guided suturing system designed to be attached to flexible endoscopes, making it accessible to a wide range of gastroenterologists and surgeons. This biodegradable, single-use device facilitates easier completion of procedures by enabling tissue approximation during surgeries. The company's solutions are intended to reduce procedure time and mortality rates in hospitals, addressing critical clinical needs for policymakers, insurers, clinicians, and patients alike.

Transcend Air develops and designs aircraft for private air travel and regional mobility, focusing on high-speed tiltwing VTOL platforms intended to transform VIP transport, defense, and city-to-city travel. The company’s patented aircraft platform leverages proven aerospace technologies, including a certified engine and whole-aircraft parachute, to offer faster, safer operations at lower operating costs compared with conventional options.

Guardion is a technology company specializing in advanced sensor technology, particularly in the development of radiation detectors that utilize the quantum properties of nanomaterials. This innovative approach allows Guardion to create low-cost, highly sensitive, and energy-efficient detectors suitable for large-scale deployment, especially in urban environments. The company focuses on applications that demand high sensitivity and miniaturization, providing analytical instruments and chemical detectors that serve various industries, including aerospace, healthcare, and national security. Guardion has received recognition for its contributions to the field, winning multiple awards such as the MassChallenge Gold Prize and the Technology in Space Prize from CASIS and Boeing. Additionally, the company participated in the inaugural cohort of the Techstars Autonomous Tech Accelerator, which is sponsored by the Air Force.

Notch Inc., located in Cambridge, Massachusetts, specializes in developing advanced metamaterial solutions that enhance antenna technology. The company's innovations enable electronically controlled beamforming, which improves communication ranges and performance. Additionally, Notch Inc. incorporates features that bolster cybersecurity, ensuring that their solutions not only optimize connectivity but also protect against potential threats. Through its cutting-edge technology, Notch Inc. aims to address the evolving needs of modern communication systems.

Emvolon is a technology company focused on creating a platform for distributed chemical production that utilizes wasted resources. The company's innovative approach involves converting wasted natural gas from flare sites into usable chemicals, which can serve a variety of industrial applications or be transformed into carbon-negative fuels. Emvolon reimagines traditional diesel engines as miniature chemical reactors, allowing for efficient and effective production without the need for large refineries or chemical plants. This process facilitates the establishment of economically viable small-scale production facilities by leveraging the advantages of mass production alongside economies of scale, ultimately providing communities with the essential raw materials they require.

BioSens8 is a developer of advanced biosensors designed to facilitate holistic health monitoring and prevent chronic diseases. The company's innovative platform offers novel quantitative and real-time biosensors that cater to various sectors. For individuals, the technology assists women in assessing their fertility health, thereby supporting family planning. In agriculture, BioSens8 provides tools for farmers to manage herd reproduction and monitor animal health. Additionally, the biosensors evaluate environmental health, contributing to the revitalization of fragile ecosystems. By serving the healthcare, agriculture, military, and biomanufacturing sectors, BioSens8 aims to enhance overall health and operational efficiency across diverse applications.

Ortholevo develops joint injectable therapies that helps to cure tight, restrained joints.

Eyebot is an innovator in eye examination technology focused on enhancing access to vision care. The company has developed a freestanding self-serve vision testing terminal that streamlines the eye examination process by delivering accurate eye prescriptions directly at the point of sale through an automated experience. This technology aims to eliminate barriers associated with obtaining vision care, allowing ophthalmologists to adopt a proactive approach to eye health. By improving the efficiency and accessibility of eye exams, Eyebot contributes to enhanced quality of life for patients while also offering potential cost savings in the delivery of vision care services.

Cyvl.ai is a technology company focused on enhancing the management of physical infrastructure assets for civil engineers and government entities. Utilizing advanced 3D mapping technology and proprietary machine learning algorithms, Cyvl.ai provides a web-based software platform that enables users to efficiently gather and analyze data on various infrastructure elements such as roads, sidewalks, signs, and trees. Their vehicle-mounted mapping sensors streamline the process of infrastructure inspections, ultimately saving time and improving safety. The platform's capability for direct integration with other asset management tools further facilitates effective data utilization, making it a valuable resource for managing infrastructure assets more effectively and affordably.

Stata DX, headquartered in Cambridge, Massachusetts, specializes in developing innovative disease management technologies. Their core product is an eRapid platform designed for custom biomarker panels, facilitating at-home patient monitoring during clinical studies. This platform employs a low-cost, affinity-based electrochemical sensing method that can simultaneously detect various biomarkers in complex biological fluids like blood, with high sensitivity and selectivity. Notably, it's particularly useful for liquid MRI scans of the brain.

BitEnergy AI is a technology company specializing in the development of advanced AI inference technology. This innovation consumes just one-tenth the energy of existing solutions, making it a more sustainable and cost-effective option for artificial intelligence applications. The company's offerings include novel neural network architectures, neuro-symbolic large models, and first-principle grounded tools. These enable clients to integrate their models with knowledge graphs and reasoning engines, leading to precise data retrieval, transparent decision-making, reduced AI costs, and streamlined processes.

Kytopen, established in 2017 and based in Cambridge, Massachusetts, specializes in the development of a cell therapy platform. This platform facilitates the non-viral delivery of molecules into challenging-to-transfect immune cells, making the process easier, faster, and more cost-effective. The company's proprietary Flowfect™ technology combines microfluidics and automation, enabling researchers to explore new biological discoveries and develop more affordable cell and gene therapies.

Feon develops new-molecule-based liquid electrolytes for lithium-ion and lithium-metal batteries.

River Otter Renewables is a recycling comany that produced biocrude oil from plant and waste as well as sewage and plastic waste.

Active Surfaces, a Massachusetts-based company, specializes in commercializing ultra-thin-film solar technology developed at MIT. Its core business involves creating flexible, lightweight solar panels that can be seamlessly integrated into everyday materials and surfaces, revolutionizing the conventional energy sector. The company's innovative manufacturing approach significantly reduces production costs, making solar power more accessible and affordable. This technology presents a transformational opportunity for semiconductor and electronics manufacturing, driving down costs for both module production and installation. By enabling virtually any surface to generate power, Active Surfaces aims to accelerate the transition to a cleaner, more sustainable future.

Western New England University, located in Springfield, Massachusetts, is a small institution known for its close-knit academic environment, where students can build meaningful relationships with faculty and peers. The university offers a range of undergraduate and graduate programs, with particular strengths in Pharmacy, Engineering, and Law. Its undergraduate offerings include disciplines from the Arts and Sciences, Business, and Engineering departments, along with a Pre-Pharmacy major that leads to its highly regarded graduate Pharmaceutical Sciences program. The campus life is vibrant, featuring a variety of cultural events and activities, such as music festivals and seasonal celebrations, fostering community engagement. Students can participate in performing arts groups, a school newspaper, and literary publications, in addition to enjoying organized campus gatherings and regional trips. Admission to undergraduate programs requires the submission of standardized applications, while graduate program applicants must meet specific departmental criteria. Scholarships and financial aid options are available, contributing to accessibility for prospective students.

Dottir Labs specializes in developing spectroscopy sensor technology tailored for aqueous environments. This technology detects and measures nutrients, metabolic markers, and both organic and non-organic waste products in real-time, empowering clients to achieve sustainability through data-driven insights.

Benchmark Labs is a San Francisco-based company specializing in AI-driven weather forecasting systems tailored for the agricultural sector and other industries. The firm provides asset-specific weather information that enhances operational efficiency and infrastructure reliability amidst changing weather conditions. By utilizing IoT sensor technology, Benchmark Labs delivers accurate forecasts that are essential for optimizing renewable energy generation and managing water resources. Its innovative platform enables clients to navigate weather variability effectively, ensuring smoother operations across various applications.

Adhesion Technologies is a bio-adhesive producer offers an alternative to toxic furniture glues, promoting to reduce chemical exposure.

Blaze Power operates as a lithium-ion battery materials manufacturer. It innovates and commercializes iron-based cathode materials to enable mass-market electrification in transportation and energy storage. The company is driven to industrialize these cathodes in purpose-built inflation reduction act-compliant facilities.

ThermoBionics is a manufacturer specializing in wearable cooling products that leverage innovative technology to enhance cooling efficiency while minimizing weight. The company focuses on developing apparel that utilizes its proprietary, patent-pending technology to artificially regulate the body's thermoregulatory functions. This allows users to reduce perspiration and promote moisture evaporation, ensuring comfort in various outdoor temperature and humidity conditions.

MacroCycle Technologies is a company developing a chemical recycling process to convert polyethylene terephthalate (PET) and polyester-fiber waste into virgin-grade plastics. Their proprietary technology, based on synthesizing cyclic macromolecules, enables the production of recycled PET with lower energy use than traditional methods. This process offers a sustainable, zero-carbon, and cost-competitive solution for plastic upcycling, contributing to a circular economy.

Worcester Polytechnic Institute (WPI), located in Worcester, Massachusetts, is a prestigious technological university founded in 1865. Renowned for its commitment to project-based learning, WPI emphasizes practical application of theoretical knowledge to address real-world challenges. The university boasts a distinguished faculty and state-of-the-art research facilities, fostering an environment rich in innovation and collaboration. WPI attracts ambitious students eager to engage in hands-on experiences that prepare them to make meaningful contributions to society. With a strong focus on developing skills that are crucial in today’s dynamic landscape, WPI positions itself as a leader in education and research, dedicated to empowering its students and faculty to achieve excellence.

EnVision Endoscopy specializes in developing innovative medical devices aimed at enhancing endoscopic surgical procedures. Their flagship product is an image-guided suturing system designed to be attached to flexible endoscopes, making it accessible to a wide range of gastroenterologists and surgeons. This biodegradable, single-use device facilitates easier completion of procedures by enabling tissue approximation during surgeries. The company's solutions are intended to reduce procedure time and mortality rates in hospitals, addressing critical clinical needs for policymakers, insurers, clinicians, and patients alike.

Aclarity, LLC is a United States-based manufacturer specializing in innovative water purification devices for residential use. Founded in 2017, the company develops advanced electrochemical water treatment systems that effectively eliminate contaminants such as pathogens, metals, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFAS), and ammonia from water. Aclarity's patented technology aims to provide cost-effective, low-maintenance solutions for comprehensive water treatment, catering to the growing need for clean water and addressing pollution challenges in both water and wastewater systems. As a venture capital-backed cleantech startup, Aclarity is focused on revolutionizing the water treatment industry with its cutting-edge approach.

AeroShield specializes in the production of super-insulating, nanoporous glass materials designed for energy-efficient windows. Utilizing silica aerogel, AeroShield's products offer optical clarity akin to traditional glass while delivering superior insulation, making them 50% more effective than conventional double-pane windows. This innovative approach not only enhances thermal comfort but also significantly improves energy performance, allowing window manufacturers to meet sustainability and compliance objectives. Additionally, the payback period for AeroShield's materials is up to five times faster than that of similarly performing windows, making them a compelling choice for the modern market.

Emvolon is a technology company focused on creating a platform for distributed chemical production that utilizes wasted resources. The company's innovative approach involves converting wasted natural gas from flare sites into usable chemicals, which can serve a variety of industrial applications or be transformed into carbon-negative fuels. Emvolon reimagines traditional diesel engines as miniature chemical reactors, allowing for efficient and effective production without the need for large refineries or chemical plants. This process facilitates the establishment of economically viable small-scale production facilities by leveraging the advantages of mass production alongside economies of scale, ultimately providing communities with the essential raw materials they require.

Florrent develops bio-based materials and high-energy-density supercapacitors derived from agricultural waste streams to address bottlenecks in decarbonization and electrification of transportation and buildings. Its technology aims to improve power quality and reliability while offering lower upfront and lifetime costs than conventional batteries, enabling commercial, industrial, and grid operators to enhance performance and support economic inclusion in underrepresented communities.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Founded in 2017 and headquartered in Boston, Southie Autonomy develops robot software that enables industrial robots to be repurposed and redeployed by users without specialized skills. Its system aims to reduce time, cost, and skill barriers for applications like kitting, palletizing, and simple assembly.

Phoenix Tailings Inc. is a company focused on producing primary metal products from mining tailings, with a commitment to sustainability and economic efficiency. Founded in 2019 and based in Woburn, Massachusetts, the company specializes in the recycling and re-mining of hazardous by-products, particularly Bauxite Residue, from the aluminum industry. By treating mining and refining waste as a new source of ore, Phoenix Tailings aims to extract strategic materials essential for various industries, including aerospace, defense, automotive, biotechnology, and more. The company's innovative approach not only facilitates the recovery of valuable metals but also addresses environmental concerns by reducing hazardous waste and providing carbon-free alternatives for metal sourcing.

Fourier is a thermal management solutions ranging from high power density electronics to renewable energy to space applications.

Rendever offers a virtual reality and shared experiences platform designed to reduce social isolation by fostering personal connections among seniors in living communities and hospitals. The platform enables group sessions where participants can check off bucket list items, revisit meaningful places, share stories, and stay engaged with family, helping improve mental well-being and quality of life. It is used by major senior living operators such as Revera, Benchmark, and SRG, and by healthcare systems including UCHealth and Cleveland Clinic, with NIH and NIA-funded research and partnerships with organizations like AARP and Verizon.

Notch Inc., located in Cambridge, Massachusetts, specializes in developing advanced metamaterial solutions that enhance antenna technology. The company's innovations enable electronically controlled beamforming, which improves communication ranges and performance. Additionally, Notch Inc. incorporates features that bolster cybersecurity, ensuring that their solutions not only optimize connectivity but also protect against potential threats. Through its cutting-edge technology, Notch Inc. aims to address the evolving needs of modern communication systems.

Feon develops new-molecule-based liquid electrolytes for lithium-ion and lithium-metal batteries.

Founded in Boston in 1995, AmberGen specializes in innovative photonic technology for therapeutics and diagnostics. The company's core expertise lies in proteomics and light-based control of biomolecules, aiming to advance medical research and diagnosis through high-resolution, multiplexed analysis of biomarkers.

Reveal Pharmaceuticals is a developer of innovative MRI contrast agents that aim to provide a safer, gadolinium-free alternative to traditional Gadolinium-Based Contrast Agents (GBCAs). The company's focus is on creating precision imaging agents that enhance diagnostic capabilities in areas such as pulmonary embolism and cancer. By leveraging its patented RVP platform, Reveal Pharmaceuticals integrates targeted molecular probes into its imaging solutions, allowing for safer scans without the need for biopsies. This approach supports the growing emphasis on personalized medicine and targeted therapeutics, ensuring that patients receive crucial medical imaging with reduced risk.

Kanda Industries designs and manufactures the custom furnitures for homes and Offices.

Founded in 2020, Irradiant Technologies specializes in developing advanced lithography techniques for high-throughput microfabrication. Headquartered in Cambridge, Massachusetts, the company's core technology enables ultrafast three-dimensional assembly of diverse materials with nanoscale precision, facilitating innovation in photonic and optical components for telecommunications, computation, and sensing.

Advanced Silicon Group is a nanotechnology company founded in 2015, focused on commercializing innovative silicon nanotechnology developed by its employees. The company specializes in measuring host cell proteins in biomanufacturing, utilizing its advanced technology to enhance various applications, including photovoltaics, lithium-ion batteries, microfluidics, and micro-electromechanical systems (MEMS). Advanced Silicon Group is also engaged in the development of next-generation biosensors, leveraging silicon to enable multiplexed measurements that allow for the simultaneous detection of multiple protein concentrations. This capability aids clients in improving performance and reducing costs by integrating silicon nanowire arrays into their products.

EnVision Endoscopy specializes in developing innovative medical devices aimed at enhancing endoscopic surgical procedures. Their flagship product is an image-guided suturing system designed to be attached to flexible endoscopes, making it accessible to a wide range of gastroenterologists and surgeons. This biodegradable, single-use device facilitates easier completion of procedures by enabling tissue approximation during surgeries. The company's solutions are intended to reduce procedure time and mortality rates in hospitals, addressing critical clinical needs for policymakers, insurers, clinicians, and patients alike.

Haystack Ag supports growers and global carbon markets with tools for high-accuracy, cost-effective soil carbon measurement.

Seia Bio is a biotechnology company that specializes in the development and production of non-model microbes. These are beneficial microorganisms that are not typically studied in laboratories but play crucial roles in various industries, such as agriculture. Seia Bio's core business involves enhancing the shelf-life and temperature stability of these non-model microbes through a proprietary coating technology. This process protects the microbes from harsh environmental conditions, ensuring their viability and effectiveness. By doing so, Seia Bio aims to improve the yield and sustainability of crops, ultimately benefiting farmers and the agricultural industry.

AI platform producing compostable and biodegradable plastic alternatives

Northeastern University, founded in 1898, is a private, research-intensive university located in Boston, Massachusetts. It offers a wide range of undergraduate and graduate programs, including doctorate degrees, across nine colleges and schools. Additionally, it provides select advanced degrees at graduate campuses in Charlotte, North Carolina, and Seattle. The university is renowned for its experiential learning approach, integrating real-world experience into its academic curriculum.

Aclarity, LLC is a United States-based manufacturer specializing in innovative water purification devices for residential use. Founded in 2017, the company develops advanced electrochemical water treatment systems that effectively eliminate contaminants such as pathogens, metals, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFAS), and ammonia from water. Aclarity's patented technology aims to provide cost-effective, low-maintenance solutions for comprehensive water treatment, catering to the growing need for clean water and addressing pollution challenges in both water and wastewater systems. As a venture capital-backed cleantech startup, Aclarity is focused on revolutionizing the water treatment industry with its cutting-edge approach.

Osmoses is a company focused on decarbonizing gas separations to significantly reduce carbon emissions, aiming to eliminate one gigaton of carbon emissions annually. It operates a clean membrane technology system designed to lower energy consumption and carbon emissions in industrial processes. The company's molecular filters are specifically engineered for exceptional size selectivity, allowing them to purify hydrogen and natural gas effectively while also enabling large-scale carbon capture. By transforming chemical separations, Osmoses helps industrial clients reduce costs and product loss, ultimately generating value and contributing to climate change mitigation efforts.

Stitch3D offers a cloud-based platform for hosting, viewing, analyzing, and sharing complex 3D files. It employs AI and machine learning algorithms to simplify the translation of spatial data into actionable insights.

Gel4Med LLC is a Boston-based medical technology company founded in 2015, specializing in the development of innovative biomaterials for tissue treatment and regeneration. The company focuses on creating an antimicrobial tissue-scaffolding matrix that addresses the challenge of antibiotic-resistant bacteria while facilitating tissue regeneration. Utilizing bioinspired and engineering approaches, Gel4Med's technology aims to improve patient outcomes in various therapeutic areas, particularly in wound care and tissue regeneration. Their leading asset features a self-assembling peptide technology that acts as both an antibacterial barrier and a promoter of tissue regeneration, enabling patients to prevent infections during surgical procedures.

Loop CO2 specializes in transforming carbon dioxide into valuable products like cosmetic oils, adhesives, and thermoplastic elastomers. This innovative process enables clients to minimize their environmental impact by adopting eco-friendly alternatives.

Founded in 2021, Z-Polymers is a clean-tech materials science company based in Lowell, Massachusetts. It specializes in developing thin fiber polymers to address fundamental challenges in critical industries such as 3D printing and the hydrogen economy, aiming to replace toxic substances with sustainable alternatives.

PathMaker Neurosystems is a clinical-stage neurotechnology company that develops neuromodulation therapies for neuromotor disorders, including amyotrophic lateral sclerosis. The company focuses on non-invasive, multi-site direct current stimulation to modulate neural pathways and spinal motor neurons involved in disease processes. Its approach aims to reduce protein aggregation and motor neuron hyperexcitability, with the goal of improving motor function and potentially extending survival for ALS patients.

Electrified Thermal Solutions is a Massachusetts-based company founded in 2021 that focuses on decarbonizing industrial processes by replacing fossil fuels with renewable heat. Originating from research at MIT's Department of Nuclear Science and Engineering, the company has developed innovative energy storage technology that converts intermittent renewable electricity into constant heat. This is achieved through the use of low-cost conductive ceramic blocks, allowing various industrial sectors to utilize zero-carbon heat effectively. By providing a sustainable alternative for furnaces, turbines, boilers, and kilns, Electrified Thermal Solutions aims to drive an energy revolution and significantly reduce carbon emissions in industry.

AeroShield specializes in the production of super-insulating, nanoporous glass materials designed for energy-efficient windows. Utilizing silica aerogel, AeroShield's products offer optical clarity akin to traditional glass while delivering superior insulation, making them 50% more effective than conventional double-pane windows. This innovative approach not only enhances thermal comfort but also significantly improves energy performance, allowing window manufacturers to meet sustainability and compliance objectives. Additionally, the payback period for AeroShield's materials is up to five times faster than that of similarly performing windows, making them a compelling choice for the modern market.

Eden is focused on developing a sustainable platform for natural resource recovery, aiming to create a carbon-neutral future. The company has introduced a novel method known as Pulsed Electrical Well Stimulation (PEWS), which is a patent-pending technology designed to replace traditional hydraulic fracturing. This innovative approach eliminates the need for water injection and addresses the logistical challenges and environmental risks associated with conventional fracking methods. By utilizing high-voltage electricity and proprietary modeling techniques, Eden enhances rock permeability with precision, facilitating effective resource extraction across various geological settings. This technology not only reduces costs but also minimizes the negative impacts typically associated with hydraulic fracturing, positioning Eden as a leader in environmentally responsible resource recovery.

Founded in 2022, Atlantic Quantum specializes in developing scalable quantum computers to address complex computational challenges. The company focuses on creating fault-tolerant quantum hardware as a key step towards advancing quantum computing.

Florrent develops bio-based materials and high-energy-density supercapacitors derived from agricultural waste streams to address bottlenecks in decarbonization and electrification of transportation and buildings. Its technology aims to improve power quality and reliability while offering lower upfront and lifetime costs than conventional batteries, enabling commercial, industrial, and grid operators to enhance performance and support economic inclusion in underrepresented communities.

Talking Heads Wireless is a telecommunication company that helps in energy savings for cellular networks.

The University of Massachusetts Amherst is a public research and land-grant university that offers undergraduate, master's, and doctoral programs. It serves as the flagship campus of the University of Massachusetts system. The university has multiple academic departments and research facilities that support a range of disciplines.

Aloft Systems specializes in maritime transportation through the development of innovative wind propulsion technology. This technology aims to reduce emissions and save fuel on existing vessels by utilizing direct wind propulsion. The company offers self-contained wind propulsion units that can be integrated into various ships, along with software that operates these units autonomously. This enables shipping companies to transport cargo efficiently along point-to-point routes, enhancing delivery reliability while significantly cutting emissions and eliminating fuel costs. Aloft Systems' commitment to zero-emission propulsion makes its solutions accessible to a wide range of vessels, positioning it as a leader in sustainable maritime transportation.

Arrakis Materials converts CO₂ into carbon-negative minerals, enabling carbon storage and utilization.

Prisere LLC specializes in enhancing business resilience against global disasters and disruptions. It offers consulting services that include risk communications, mapping, and software applications, along with training and technical advisory services. The company collaborates with institutions to provide expertise in disaster risk reduction, using technology to improve risk management and facilitate access to affordable insurance. This enables businesses to bolster long-term profitability and stability, particularly in regions underserved by traditional risk mapping and modeling tools.

Stepwise specializes in home electrification services. They offer smart devices that monitor energy consumption, manage electric loads like EV chargers, facilitate heat pump installations, and ensure compliance with safety standards and utility programs.

Lithios is a technology company specializing in advanced lithium extraction through innovative electrochemical processes. The company focuses on capturing and releasing lithium from complex mixtures, addressing the growing demand for lithium in various industries, particularly in the electric vehicle sector. By leveraging breakthroughs in applied electrochemistry, Lithios offers solutions that facilitate low-cost and selective extraction of lithium from untapped brine resources. Their sustainable electrochemical methods aim to enhance the efficiency and effectiveness of lithium extraction, contributing to a more sustainable future in energy and technology.

Carbix develops weathering technologies that convert CO2 emissions into building materials. It uses a bioreactor to capture CO2 from industrial plant flue gas and combines it with mineral inputs and energy from renewable sources or energy-from-waste to accelerate sequestration and form carbonates that serve as raw materials for construction products and other industrial applications.

InGel Therapeutics is a biotechnology company based in Cambridge, Massachusetts, founded in 2021. The company focuses on developing engineered cell therapies aimed at targeting neuroprotective pathways to address retinal degeneration. Utilizing stem cells and their secretome, InGel Therapeutics aims to provide neuroprotection for blinding diseases such as retinitis pigmentosa and macular degeneration. The company leverages biodegradable polymers to isolate neuroprotective proteins, initially testing these solutions in vitro before advancing to in vivo applications. Through its innovative approach, InGel Therapeutics seeks to enable healthcare professionals to more effectively treat patients suffering from retinal degeneration.

Jetcool Technologies Inc., established in 2019 and headquartered in Littleton, Massachusetts, specializes in the research and development of advanced chip cooling solutions. The company offers a range of cooling products, from bare die to system level, and provides customized solutions. Jetcool's innovative microjet cooling modules, developed at MIT Lincoln Laboratory, are designed to efficiently cool high-power electronics in industries such as defense and aerospace, advanced semiconductors, data centers, and electric vehicle power systems. The company's technology, published in several academic papers, uses small jets of fluid to cool components at the chip or device scale, enabling manufacturers to create more durable, energy-efficient products.

AeroShield specializes in the production of super-insulating, nanoporous glass materials designed for energy-efficient windows. Utilizing silica aerogel, AeroShield's products offer optical clarity akin to traditional glass while delivering superior insulation, making them 50% more effective than conventional double-pane windows. This innovative approach not only enhances thermal comfort but also significantly improves energy performance, allowing window manufacturers to meet sustainability and compliance objectives. Additionally, the payback period for AeroShield's materials is up to five times faster than that of similarly performing windows, making them a compelling choice for the modern market.

AeroShield specializes in the production of super-insulating, nanoporous glass materials designed for energy-efficient windows. Utilizing silica aerogel, AeroShield's products offer optical clarity akin to traditional glass while delivering superior insulation, making them 50% more effective than conventional double-pane windows. This innovative approach not only enhances thermal comfort but also significantly improves energy performance, allowing window manufacturers to meet sustainability and compliance objectives. Additionally, the payback period for AeroShield's materials is up to five times faster than that of similarly performing windows, making them a compelling choice for the modern market.

Harmony is a biotechnology startup that creates human breast milk protein-based infant nutrition designed to help human babies thrive. It is the world’s first dairy-free, allergen-free and environmentally friendly infant nutrition. Harmony Baby Nutrition was established in 2018 and is based in Boston, MA.

Leuko Labs, Inc., established in 2017 and headquartered in Boston, Massachusetts, specializes in the development of healthcare equipment. The company's primary product, PointCheck, is a non-invasive device designed to monitor and count white blood cells. This innovative technology allows for more frequent testing of immunosuppressed patients, such as those undergoing chemotherapy, enhancing their quality of life and clinical outcomes. The device is particularly beneficial as it eliminates the need for invasive blood draws and laboratory infrastructure, making it more accessible and convenient for patients.

Cyvl.ai is a technology company focused on enhancing the management of physical infrastructure assets for civil engineers and government entities. Utilizing advanced 3D mapping technology and proprietary machine learning algorithms, Cyvl.ai provides a web-based software platform that enables users to efficiently gather and analyze data on various infrastructure elements such as roads, sidewalks, signs, and trees. Their vehicle-mounted mapping sensors streamline the process of infrastructure inspections, ultimately saving time and improving safety. The platform's capability for direct integration with other asset management tools further facilitates effective data utilization, making it a valuable resource for managing infrastructure assets more effectively and affordably.

Kinto.Care is an online platform designed to enhance communication and support for caregivers, particularly those caring for loved ones with dementia. The platform offers user-generated content and digital tools that facilitate care team collaboration, medication management, and tracking of health data. By providing practical advice, care planning, and group learning opportunities, Kinto.Care aims to empower family members to effectively coordinate care and manage their loved ones' medical needs through a unified interface.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Pison Technology, Inc., established in 2016 and headquartered in Boston, Massachusetts, specializes in developing and marketing wearable devices. These devices are designed to capture and filter signals sent to the nervous system, primarily serving individuals with amyotrophic lateral sclerosis (ALS). Pison's innovative, non-invasive electroneurography (ENG) algorithms and sensor array technology aim to optimize cognitive and physiological capabilities through gesture control, with applications in cognitive enhancement, disease diagnosis, management, and improving overall quality of life.

Reveal Pharmaceuticals is a developer of innovative MRI contrast agents that aim to provide a safer, gadolinium-free alternative to traditional Gadolinium-Based Contrast Agents (GBCAs). The company's focus is on creating precision imaging agents that enhance diagnostic capabilities in areas such as pulmonary embolism and cancer. By leveraging its patented RVP platform, Reveal Pharmaceuticals integrates targeted molecular probes into its imaging solutions, allowing for safer scans without the need for biopsies. This approach supports the growing emphasis on personalized medicine and targeted therapeutics, ensuring that patients receive crucial medical imaging with reduced risk.

EnVision Endoscopy specializes in developing innovative medical devices aimed at enhancing endoscopic surgical procedures. Their flagship product is an image-guided suturing system designed to be attached to flexible endoscopes, making it accessible to a wide range of gastroenterologists and surgeons. This biodegradable, single-use device facilitates easier completion of procedures by enabling tissue approximation during surgeries. The company's solutions are intended to reduce procedure time and mortality rates in hospitals, addressing critical clinical needs for policymakers, insurers, clinicians, and patients alike.

Eden is focused on developing a sustainable platform for natural resource recovery, aiming to create a carbon-neutral future. The company has introduced a novel method known as Pulsed Electrical Well Stimulation (PEWS), which is a patent-pending technology designed to replace traditional hydraulic fracturing. This innovative approach eliminates the need for water injection and addresses the logistical challenges and environmental risks associated with conventional fracking methods. By utilizing high-voltage electricity and proprietary modeling techniques, Eden enhances rock permeability with precision, facilitating effective resource extraction across various geological settings. This technology not only reduces costs but also minimizes the negative impacts typically associated with hydraulic fracturing, positioning Eden as a leader in environmentally responsible resource recovery.

Founded in 2018, Radical Plastics develops a proprietary catalyst that renders plastic compounds biodegradable in natural environments. Its primary product is soil degradable compounds for agricultural film.

Gradient is a developer of secure software that addresses fundamental issues of trust and authenticity in the digital landscape. The company's solutions focus on redefining identity and data authentication, providing a framework for establishing trust and facilitating the sharing of provable statements while ensuring privacy and security. This enables users to collaborate openly without sacrificing digital security or integrity. Gradient's infrastructure is designed to foster decentralized trust, contributing to safer and more reliable digital interactions.

Jaxon.AI develops an artificial intelligence platform that guides data science teams through the research, design, and build phases. It leverages technologies such as ChatGPT to address domain- and use-case-specific problems and creates blueprints to keep users on the optimal path. The platform features a proprietary reasoning engine that simulates model performance to compare tradeoffs and identify effective approaches for each problem. It also targets reducing AI hallucinations by enabling an automated design cycle with formal methods, helping teams improve reliability and consistency in AI projects.

Leuko Labs, Inc., established in 2017 and headquartered in Boston, Massachusetts, specializes in the development of healthcare equipment. The company's primary product, PointCheck, is a non-invasive device designed to monitor and count white blood cells. This innovative technology allows for more frequent testing of immunosuppressed patients, such as those undergoing chemotherapy, enhancing their quality of life and clinical outcomes. The device is particularly beneficial as it eliminates the need for invasive blood draws and laboratory infrastructure, making it more accessible and convenient for patients.

Extend Biosciences Inc. is an emerging biotechnology company developing a novel drug delivery platform technology that improves the pharmacokinetic properties of peptides and proteins. Peptides have been particularly challenging to bring to market because they are removed from circulation prior to administering therapeutic value. Their proprietary platform technology significantly improves the circulating half-life and bioavailability of peptides and proteins, enabling the scientific community to truly develop potent and specific drugs. Their mission is to revolutionize drug delivery and give patients a better quality of life.

Founded in Boston in 1995, AmberGen specializes in innovative photonic technology for therapeutics and diagnostics. The company's core expertise lies in proteomics and light-based control of biomolecules, aiming to advance medical research and diagnosis through high-resolution, multiplexed analysis of biomarkers.

Founded in 2018 by Drs. Veronika Stelmakh and Walker Chan, Mesodyne is a pioneering engineering and manufacturing company specializing in innovative electricity generation methods. Their patented LightCell technology converts any fuel to electricity via light, providing rugged, long-lasting, portable power for military and commercial users.

Aclarity, LLC is a United States-based manufacturer specializing in innovative water purification devices for residential use. Founded in 2017, the company develops advanced electrochemical water treatment systems that effectively eliminate contaminants such as pathogens, metals, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFAS), and ammonia from water. Aclarity's patented technology aims to provide cost-effective, low-maintenance solutions for comprehensive water treatment, catering to the growing need for clean water and addressing pollution challenges in both water and wastewater systems. As a venture capital-backed cleantech startup, Aclarity is focused on revolutionizing the water treatment industry with its cutting-edge approach.

The principal mission of the Company is to provide technology and technology services to industry and public sector agencies for enhanced productivity, improved safety, and reduced costs.

PathMaker Neurosystems is a clinical-stage neurotechnology company that develops neuromodulation therapies for neuromotor disorders, including amyotrophic lateral sclerosis. The company focuses on non-invasive, multi-site direct current stimulation to modulate neural pathways and spinal motor neurons involved in disease processes. Its approach aims to reduce protein aggregation and motor neuron hyperexcitability, with the goal of improving motor function and potentially extending survival for ALS patients.