Rev1 Ventures is a venture capital firm based in Columbus, Ohio. Established in 2005, it focuses on seed-stage investments across various sectors including enterprise software, digital health, life sciences, food tech, advanced materials, and alternative energy. With over $100 million under management, Rev1 provides strategic services alongside capital to help startups scale and corporates innovate.

CincyTech is a Cincinnati-based organization that identifies and nurtures early-stage health, technology, and life sciences startups in Southwest Ohio. It provides strategic guidance, capital, and operational support to entrepreneurs and researchers seeking to commercialize technology, and connects them with regional investors and institutions. By supporting university and hospital research commercialization and catalyzing local investment, CincyTech helps turn innovative ideas into growth companies. The organization collaborates with major regional partners such as Cincinnati Children’s Hospital Medical Center, the University of Cincinnati, and the Cincinnati USA Regional Chamber, and leverages a broad network of funders to back seed-stage ventures across information technology, healthcare, software, and other tech sectors in Ohio and the Midwest.

North Coast Ventures, established in 2006, is a Cleveland-based investment firm focused on early-stage technology companies in the United States. It operates as a professionally managed angel fund, comprising four contributed capital funds. The firm's membership consists of prominent Ohio investors, entrepreneurs, and business leaders who actively support and mentor portfolio companies. North Coast Ventures aims to enhance the early-stage funding environment for both entrepreneurs and investors in the Northeast Ohio region.

Founded in 2012, Drive Capital is a venture capital firm headquartered in Columbus, Ohio. It invests in innovative technology, healthcare, and consumer companies across the Midwest region.

Service Provider Capital is a venture capital firm established in 2014 and based in Colorado. The firm focuses on early-stage investments, notably seed-stage opportunities, and participates as a co-investor in Series A rounds led by institutional venture funds. Its portfolio interests span a broad range of technology sectors, including artificial intelligence, machine learning, blockchain, cybersecurity, e-commerce, education technology, fintech, hardware, information technology, robotics, health, and cannabis.

Ohio Innovation Fund, established in 2016 and headquartered in Columbus, Ohio, is a venture capital firm focusing on early-stage investments. It partners with visionary founders to support the growth of disruptive companies, primarily in the technology sector. The firm's investment focus spans across medical technology, biopharma, AR/VR, advanced manufacturing, SaaS, AI/ML, cybersecurity, and mobility. Typically investing between $250,000 to $500,000 initially, with follow-on investments up to $1.25 million based on milestones, Ohio Innovation Fund aims to foster innovation and create industries of the future within the United States, with a particular emphasis on Ohio-based startups.

Mutual Capital Partners, established in 2004, is a private equity firm headquartered in Westlake, Ohio. The company specializes in venture capital investments, focusing on medical device and healthcare IT companies across the United States. It typically leads or co-leads investments, providing not only capital but also strategic guidance and operational support to its portfolio companies. The firm works closely with its network of over 100 investors, leveraging their expertise for due diligence, customer introductions, and ongoing executive counsel.

Founded in Columbus, Ohio in 2000, NCT Ventures is a venture capital firm focused on supporting seed and early-stage technology companies across the Midwest. They typically invest between $250k to $1 million initially, with potential follow-on investments of up to $5 million as portfolio companies grow. The firm brings over two decades of entrepreneurial experience and offers hands-on operational support to help visionary entrepreneurs succeed.

Ohio TechAngel Fund III operates as an angel investment network focused on supporting early-stage companies in Ohio, particularly in the sectors of information technology, advanced materials, life sciences, healthcare, and other emerging industries. Managed by Rev1 Ventures and Ohio Tech Angels, the fund draws upon a diverse group of over 340 accredited investors, making it one of the largest angel networks in North America. This organization emphasizes the growth of promising C-Corporations based in Ohio, with investments typically ranging from $100,000 to $500,000. The fund's mission is to transform innovative ideas into successful businesses that contribute to economic growth and entrepreneurial wealth in the region. To date, it has invested significantly in numerous companies, fostering job creation and revenue generation, while also maintaining a network of collaborators to enhance the support available to its investees.

Insight Partners is a global private equity and venture capital firm founded in 1995 that acts as a software investor, partnering with growth-stage technology and software companies. The firm concentrates on Fintech, Cybersecurity, AI/ML, DevOps, and Healthcare, providing capital and hands-on support to help management teams scale. Headquartered in New York City with offices in London, Tel Aviv, and Palo Alto, Insight Partners has more than $75 billion in assets under management, has invested in over 750 companies worldwide, and more than 55 portfolio companies have reached an IPO.

Interstate Fusion Ventures is a venture capital firm based in Akron, Ohio, established in 2014. It concentrates on investing in information technology startups, primarily in Northeast Ohio, to strengthen the Midwest startup ecosystem by connecting local, regional, and coastal opportunities. The firm pursues a diversified technology portfolio and supports early-stage companies contributing to regional economic development.

Founded in 2015, Valley Growth Ventures is a venture capital firm based in Youngstown, Ohio. It focuses on investing in early-stage companies across various sectors, including software, information technology, healthcare, energy, additive manufacturing, and advanced materials.

Founded in 2017, Tamarind Hill is a venture capital firm based in Dublin, Ohio. It provides entrepreneurial stage capital to SaaS companies focused on B2B markets such as healthcare IT and enterprise IT, primarily investing throughout the Midwestern U.S.

Advantage Capital Partners is a United States‑based venture capital firm that provides growth equity, debt, and mezzanine financing to small and mid‑market companies, with a focus on underserved communities and state and local economic development. The firm invests across sectors including manufacturing, technology, business services, life sciences, and energy, and also supports real estate development projects with equity and debt. It typically makes initial investments ranging roughly from half a million to ten million in companies with modest sales, and may participate in larger follow‑on rounds or co‑invest with other firms. It uses senior debt, mezzanine debt, subordinated loans, and government‑guaranteed lending, and often pursues equity positions through preferred shares or convertible notes. Advantage Capital operates nationwide in the United States, with roots in New Orleans and offices in multiple states, and has backed thousands of jobs and housing projects as part of its mission to expand inclusive economic growth.

Founded in 2011, Jumpstart Ventures is a venture capital firm based in Cleveland, Ohio. It partners with entrepreneurs to invest in companies that aim to solve complex problems through intelligent innovation and ambitious solutions, focusing on sectors such as enterprise software, data analytics, biomedical tech, devices, insurtech, fintech, and life sciences.

M25 is a Chicago-based venture capital firm established in 2015 by Victor Gutwein and Mike Asem, focused on funding pre-seed and seed-stage technology startups in the Midwest. The firm supports portfolio companies across multiple industries, with a regional footprint spanning 24 Midwest cities in 11 states. Since its inception, M25 has backed more than 90 early-stage tech startups, aiming to accelerate growth and strengthen the Midwest startup ecosystem.

Founded in 2023, Fireroad is a venture capital firm based in Cincinnati, Ohio. It specializes in providing growth investments and venture capital to startups, with a focus on the technology industry.

LaunchHouse is a venture capital firm and business accelerator that invests in early-stage technology startups, with a focus on data, SaaS, healthcare software, and other innovative sectors. It provides not only capital, typically investing $0.03 million, but also incubator services and access to a curated community of founders, engineers, and investors. This community offers coliving residencies, executive coaching, fundraising support, and digital courses, fostering learning, professional development, and authentic relationships. LaunchHouse operates in major cities like Los Angeles and New York, as well as in the metaverse, with a mission to create a hub for entrepreneurial innovation and transform ideas into successful companies.

Refinery Ventures is an early-stage venture capital firm based in Cincinnati, Ohio, founded in 2017. It focuses on investing in information technology, digital health, and human capital technology sectors, with an emphasis on helping post-seed companies bridge the gap to Series A. The firm supports its portfolio through mentorship and strategic guidance, aiming to accelerate growth for technology-enabled startups in healthcare technology systems and software, SaaS, and enterprise software.

NDI Medical LLC, Investment Arm is a venture capital firm specializing in seed and startup stage investments. It seeks to invest in the medical equipment, neurodevices, medical devices, stimulators, leads, surgical equipment and software to treat illnesses of the brain and nervous system sectors. NDI Medical, Investment Arm was founded in 2002 and is based in Cleveland, Ohio with additional offices in Chapel Hill, North Carolina and Minneapolis, Minnesota.

Greycroft is a venture capital firm that concentrates on technology start-ups, with a focus on the internet and mobile markets. It operates from offices in New York and Los Angeles, and uses its media and technology industry connections to help portfolio companies gain visibility, build strategic relationships, bring products to market, and grow successful businesses. Founded in 2006, Greycroft has invested in more than 200 companies across sectors such as consumer internet, financial technology, healthcare, and enterprise software, and manages over $1 billion in capital. The firm emphasizes early-stage investing and collaborates with entrepreneurs to support growth, while pursuing diversity initiatives including a diversity term sheet rider.

Tiger Global Management is a New York based investment firm that manages public and private market strategies to pursue technology-driven growth opportunities worldwide. Founded in 2001 by Charles (Chase) Coleman, the firm invests in leading global companies across various industries, with a particular emphasis on technology-enabled growth. In public markets it employs long/short and growth strategies, while in private markets it targets opportunities from early to late stage. The firm operates globally, including the United States, China, India, Latin America, and Eastern Europe, and works with portfolio companies across their lifecycle to drive long-term value.

EVC Ventures is a private equity and venture capital firm established in 2014, with its headquarters in Miami, Florida, and additional offices in Chicago, Illinois, and Gurgaon, India. The firm focuses on early-stage and mid-stage investments, primarily in sectors such as EdTech, Artificial Intelligence, SaaS, mobile applications, security, augmented and virtual reality, drone technology, robotics, e-commerce, and gaming. EVC Ventures typically invests between $0.1 million and $5 million in its portfolio companies, and it operates two accelerator programs that provide funding ranging from $5,000 to $100,000 in exchange for equity. The firm prefers to back companies built on its I-MADE program, supporting entrepreneurs with both capital and strategic guidance to foster growth and innovation in the tech landscape.

LOUD Capital is a venture capital and alternative investment firm founded in 2015 by Darshan Vyas and Navin Goyal. Based in Ohio, the firm provides capital, education, and advisory services to help grow impactful companies.

Sica Ventures is an early-stage investment company based in Columbus, Ohio, established in 2019. The firm specializes in providing seed capital to innovative technology startups, focusing primarily on the aerospace, defense, and space sectors. Sica Ventures aims to support promising ventures through minority investments during their seed and early stages, contributing to the development of cutting-edge solutions in these critical industries.

CincyTechUSA, Investment Arm is a venture capital firm specializing in seed stage and start-up financing. They primarily invest in a variety of sectors including enterprise software, technology-enabled services, digital marketing, bioscience, and digital health care. The firm focuses on companies located in or willing to relocate to the Southwest Ohio region, specifically in the greater Cincinnati area. With investments ranging from $0.5 million to $3 million, they target companies with revenues under $5 million and fewer than 30 employees, aiming for revenue growth to $30-50 million within five to seven years. CincyTechUSA utilizes convertible debt for investments, with an interest in obtaining observer status on the Board of Directors of their portfolio companies. Founded in 2001, the firm is headquartered in Cincinnati, Ohio.

Nationwide Ventures, LLC is a financial investment firm based in Columbus, Ohio, established in 2016. The company focuses on investing in early, mid, and late-stage startups, particularly in the sectors of fintech, insurtech, and innovative solutions for retirement and financial services. By concentrating on customer-centric platforms that utilize digital, mobile, and analytics technologies, Nationwide Ventures aims to enhance the experiences of its clients. The firm typically invests between $1 million and $5 million, seeking to pilot new technologies and test novel solutions and business models.

Ikove Capital Partners is a venture development company based in Columbus, Ohio, that specializes in early-stage investments, particularly in technology commercialization. Founded in 2014 by Rodolfo Bellesi and Flavio Lobato, the firm collaborates with various U.S. research institutions through its proprietary Startup Nursery, which helps identify and validate high-impact technologies. Ikove provides essential capital and commercialization resources to assist in bridging the gap between research and development and subsequent venture capital funding. The company focuses on supporting concept technology firms by offering both investment and advisory services to facilitate their growth and market entry.

Athenian Venture Partners, established in 1997, is a venture capital firm headquartered in Athens, Ohio. It specializes in early-stage investments, focusing on innovative companies in the Information Technology, Healthcare, and Digital Health sectors across the United States. Athenian takes a hands-on, active approach, collaborating with entrepreneurs to build successful businesses and drive economic growth in its target markets. The firm aims to deliver maximum shareholder value by engaging with company management throughout the business lifecycle.

Triathlon Medical Ventures was a venture capital firm focused on life sciences, including drugs, biomedicine, medical devices, biotechnology, and diagnostics, with activity primarily in the Midwest United States. It invested in seed through expansion stages, typically in the range of 0.5 to 10 million dollars, and sought to lead investments, often taking a board seat for early rounds and a board observer role for later rounds. The firm originated in Ohio, with its base in Cincinnati and additional Midwest offices, and supported companies developing proprietary biomedical technology addressing significant healthcare needs. The firm ceased operations at the end of 2022.

Early Stage Partners is a Cleveland-based venture capital firm that provides early-stage financing to U.S. technology companies. Founded in 2001, the firm targets early-stage investments across the Midwest and the broader United States, with emphasis on healthcare technologies, information technology, advanced manufacturing, and industrial technologies. It partners with entrepreneurial teams to support the growth of early-stage ventures in the technology sectors, helping companies scale from concept to market.

Detroit Venture Partners is a Detroit-based venture capital firm that focuses on seed and early-stage technology investments across the United States, with emphasis on Detroit and Ontario. The firm backs internet, digital media, marketing technology, direct-to-consumer, sports and entertainment, social media, e-commerce, software, B2B software, mobile applications, and related sectors such as Adtech and enterprise software-as-a-service. It typically makes initial investments in the range of USD 0.25 to 0.75 million, with follow-on rounds between 2 and 3 million, and can participate up to about 3 million per investment. Founded in 2010, it aims to support entrepreneurial ventures that help rebuild the Detroit area and foster growth in technology-driven businesses.

Reservoir Venture Partners, established in 2001, is a private equity firm headquartered in Ohio. It specializes in early-stage investments, focusing primarily on information technology and healthcare technology companies. The firm, founded by Chris Selland, aims to support innovative startups in these sectors, fostering their growth and success.

Founded in 2018, Break Trail Ventures is a venture capital firm headquartered in Columbus, Ohio with an additional office in Boulder, Colorado. The firm specializes in early-stage and growth capital investments across sectors such as consumer products, advanced manufacturing, big data, digital health, e-commerce, mobile & SaaS.

Vine Street Ventures is a venture capital firm based in Cincinnati, Ohio, focused on growth capital investments in internet and mobile businesses, including software and technology, media and telecommunications sectors.

Comeback Capital is a Cleveland, Ohio-based venture capital firm that backs early-stage startups, with a focus on the Midwest. It pursues pre-seed and seed investments across technology, supply chain and logistics, health tech, mobility, and the industrial Internet of Things. The firm supports portfolio companies to accelerate execution and leverages a broad network, including connections to advisors from established startup markets, to help companies scale.

Vora Ventures is a venture capital firm founded in 2005 and headquartered in Cincinnati, Ohio. It specializes in building and supporting information technology companies in software, services, and infrastructure solutions worldwide. The firm engages in venture investments and, in addition to investing, serves on the advisory board of seed-stage funds, including those focused on internet and mobile businesses.

Blue Chip Venture Company is a private equity and venture capital firm established in 1990 and headquartered in Cincinnati, Ohio, with an active national footprint. It targets technology-enabled companies in digital media and big data, serving consumer advertising, and extends its investments to media, marketing, digital marketing, healthcare, education services, diversified support services, and telecommunications. The firm typically invests in privately held US companies across early to growth stages, financing rounds ranging from a few hundred thousand to several million dollars, often via convertible preferred stock, and may include bridge loans or equity components. It aims to be the lead investor, seeks a seat on the board, and targets exits within about two years through sale, recapitalization, or an IPO. The firm collaborates with existing venture syndicates and pursues opportunities nationwide, including the Midwest and Northeast regions.

Founded in 2018, University Hospitals Ventures is the corporate venture arm of University Hospitals, based in Cleveland, Ohio. It invests across healthcare IT, medical devices, diagnostics, digital therapeutics, wellness, and enterprise operations.

Angel Physicians Fund, founded in 2020 and based in Powell, Ohio, operates as a venture capital firm specializing in seed-stage investments. Comprised of physicians and medical pioneers, the firm is dedicated to supporting companies in the life sciences and healthcare sectors. With a unique focus on bioscience and health-related ventures, Angel Physicians Fund seeks to leverage the expertise of its members to identify and nurture innovative healthcare solutions.

RiverVest Venture Partners is a venture capital firm focused on early-stage life science investments in the United States. Headquartered in St. Louis, Missouri, it maintains offices in Cleveland and San Diego and pursues opportunities in biopharma and medical device sectors. The firm operates as a registered investment adviser.

Link-age Ventures is a venture capital firm based in Mason, Ohio. It focuses on investing in early to emerging-growth companies that provide products, services, and technology for the aging population, with emphasis on healthcare and information technology. The firm targets opportunities in the United States and leverages deep knowledge of the aging demographic to identify high-potential investments. It aims to support startups addressing aging-related needs in the market.

JWI Capital, LLC is a private equity and venture capital firm based in Twinsburg, Ohio, founded in 2009. The firm specializes in acquiring and managing microcap companies, focusing on sectors such as manufacturing, defense, aerospace, energy, infrastructure, and transportation. JWI Capital seeks investments in companies generating revenue between $5 million and $50 million, with a preference for EBITDA of $1 to $3 million. The firm typically targets investments within a 300-mile radius of Northeast Ohio and is interested in both minority stakes—acquiring appropriate rights and protections—and control investments. JWI Capital also invests in related outsourced business services or distribution companies that support its targeted sectors, leveraging the expertise of its experienced management team to foster growth in the businesses it acquires.

WillowWorks, LLC is a venture capital firm based in Columbus, Ohio, specializing in early-stage investments. Established in 2016, the firm focuses on identifying innovative opportunities and forming strategic partnerships to drive growth across various markets. WillowWorks aims to support entrepreneurs and emerging companies by providing the necessary resources to foster innovation and development.

Adena Ventures is a venture capital firm based in Athens, Ohio, that provides equity capital and operational support to high-growth companies, with a focus on the Appalachian region. The firm backs growth-oriented ventures across multiple stages and industries, including information technology, healthcare, life sciences, manufacturing, food products, and sporting and recreational sectors. Its principals bring decades of experience in venture capital, financial services, strategy, and company operations to help portfolio companies accelerate growth and scale.

State Auto Labs is the venture capital arm of Rev1 Ventures, based in Columbus, Ohio, focused on seed investments in insurance, technology, data, and product and operational solutions. It combines investment and insurance expertise to support startups by providing capital, access to technologists, and guidance from industry professionals, with the aim of identifying transformative technologies and acting as an early adopter.

Founded in 2021, Overlooked Ventures is a venture capital firm based in Columbus, Ohio. It focuses on investing in early-stage companies with historically overlooked founders, primarily in the technology sector.

Founded in 1997, Redhawk Ventures is a venture capital firm based in Oxford, Ohio. It invests primarily in seed-stage startups led by Miami University students or alumni, focusing on sectors such as fintech, consumer packaged goods, technology, and e-commerce.

Bruckner Ventures is an early-stage investment firm established in 2021 and located in Columbus, Ohio. The firm operates as an angel syndicate, focusing on investments in a diverse range of sectors, including business-to-business software as a service (B2B SaaS), deep technology, artificial intelligence and machine learning (AI/ML), robotics, space, electric vehicles, financial technology (fintech), cybersecurity, and transportation. Bruckner Ventures primarily targets startups based in North America, seeking to support innovative companies that are poised for growth in these dynamic industries.

Driven Capital Partners is a venture capital firm established in 2020 and located in Strongsville, Ohio. The firm focuses on consulting with and investing in technology companies, primarily within the automotive, insurance, and finance sectors. With a team of experienced executives, Driven Capital Partners aims to support innovation and growth in these industries through strategic investments and guidance.