Cleveland State University

Enspire DBS Therapy, Inc. is dedicated to developing a proprietary deep brain stimulation (DBS) therapy aimed at restoring motor function in stroke survivors with disabilities. Founded in 2010 and based in Cleveland, Ohio, the company is currently conducting a Phase I clinical trial to evaluate the effectiveness of its DBS therapy in stroke recovery. The therapy integrates deep brain stimulation with physical rehabilitation techniques, leveraging natural pathways to enhance the effects of both stimulation and therapy. This innovative approach aims to accelerate recovery for stroke patients, offering them improved access to rehabilitation and the potential for greater restoration of motor function.

MediView, LLC is a medical device company based in Cleveland, Ohio, established in 2017. The company specializes in developing an augmented reality surgical navigation system designed to enhance the surgical process for healthcare providers. Its primary product, MediView, utilizes extended reality technology to offer real-time, fused-holographic visualization, which aids in the ablation and biopsy of cancerous tumors. This innovative approach allows surgeons to navigate procedures with greater accuracy and efficacy compared to conventional two-dimensional displays. Additionally, MediView's technology supports remote collaboration and telehealth, providing healthcare professionals with valuable insights and the ability to examine patients more effectively using three-dimensional holograms.

Centerline Biomedical, Inc. is a Cleveland-based company founded in 2014, focused on developing advanced navigation systems for interventional vascular procedures. The company specializes in a non-x-ray based, three-dimensional GPS surgical navigation technology that enhances the precision and outcomes of endovascular procedures while significantly reducing radiation exposure for both patients and healthcare providers. This innovative system assists surgeons in accurately navigating catheters and guide wires through the complex three-dimensional anatomy of patients with vascular diseases, ultimately enabling safer and more effective image-guided surgeries. The technology is rooted in research and development from the Cleveland Clinic, highlighting its commitment to improving surgical practices in the medical field.

Cleveland Diagnostics, Inc. is a commercial-stage diagnostics company based in Cleveland, Ohio, founded in 2013. The company specializes in the development and commercialization of non-invasive cancer diagnostic tests, focusing on blood-based assays for prostate, breast, and ovarian cancers, with plans to expand into lung cancer and certain neurological diseases. Cleveland Diagnostics employs proprietary solvent interaction analysis technology to investigate protein biomarkers at the structural level, enhancing the specificity and accuracy of its tests. The company has formed a strategic collaboration with Genomic Health to further its mission of improving cancer diagnostics and screening.

Advanced NanoTherapies, Inc. is a company that specializes in developing medical devices utilizing Sirolimus for the treatment of atherosclerosis and blockages associated with coronary and peripheral artery diseases. Founded in 2018, the company is based in Cleveland, Ohio, and focuses on a unique nanoparticle technology platform aimed at improving drug delivery for cardiovascular and endovascular applications. This innovative technology enhances medication uptake and retention within cells, providing clinicians with safer treatment options for patients suffering from peripheral artery disease. Through its advancements, Advanced NanoTherapies aims to address significant health challenges in the cardiovascular field.