JobsOhio is a private non-profit economic development agency based in Columbus, Ohio, established in 2011. Its primary mission is to drive job creation and stimulate capital investment across the state. The organization focuses on attracting, retaining, and expanding businesses in strategic industry sectors that leverage Ohio's strengths. With a team of industry experts, JobsOhio provides essential resources and support to meet the needs of growing businesses, ensuring they have the tools necessary for success. Through its efforts, JobsOhio plays a crucial role in enhancing the economic landscape of Ohio.
HealthPlan Data Solutions LLC (HDS), founded in 2010 by a team of experienced pharmacists and business professionals, focuses on enhancing the management of pharmacy benefits to address inefficiencies in healthcare cost containment. The company develops pharmacy distribution software that identifies billing issues, rectifies overpayments, and minimizes future discrepancies. HDS's software provides payers with real-time visibility into prescription drug claims and reconciles these claims with negotiated contracts and plan designs. By leveraging objective data, HDS empowers both commercial and government payers to better optimize their drug spending, ultimately aiming to reduce overspending and improve health outcomes.
REM Electronics
Grant in 2025
REM Electronics is a distributor and manufacturer of electronic parts and components.
Orthobrain
Venture Round in 2025
Orthobrain offers an orthodontic growth system that enables general dentists to incorporate orthodontic services into their practices effectively. By leveraging digital technology, proprietary AI-driven learning systems, and expert mentorship, Orthobrain provides a comprehensive solution that supports dentists from patient acquisition through to treatment. Their offerings include the SimplyClear aligner system, which helps patients achieve straighter smiles while providing extensive clinical support through access to U.S.-based orthodontic experts. The platform also features clinical mentoring, treatment planning, and on-demand support, facilitating the integration of pediatric dentistry, braces, and aligner treatments into dental practices. In recognition of its innovative approach, SimplyClear was awarded the Product of the Year in 2024 by a national dental distributor.
GE Aerospace
Grant in 2025
GE Aerospace is a leading provider of jet and turboprop engines, as well as integrated systems for commercial, military, business, and general aviation aircraft. The company specializes in the design, manufacturing, and servicing of large aircraft engines, and has a significant partnership with Safran in the CFM joint venture. With an extensive global installed base of nearly 70,000 engines, GE Aerospace primarily generates revenue from recurring service contracts that support equipment over decades. The company focuses on developing sustainable products and systems that incorporate next-generation technologies, achieving a 20% reduction in CO2 emissions and enhancing fuel efficiency. As the core business of the organization, which has roots dating back to 1892, GE Aerospace continues to build on its legacy while adapting to the evolving demands of the aerospace industry.
XII Medical
Series B in 2024
XII Medical is a medical device developer focused on creating innovative solutions for obstructive sleep apnea. The company has developed a minimally invasive outpatient technology that includes an implantable neurostimulation device designed to alleviate the condition. This device works by preventing the muscles in the throat from relaxing during sleep, thereby avoiding airway blockage and enabling patients to enhance oropharyngeal airflow. Through its advancements in sleep apnea treatment, XII Medical aims to improve patient outcomes and provide a proactive approach to managing this common sleep disorder.
Metallus
Grant in 2024
Metallus is an American manufacturer specializing in alloy steel, carbon steel, and micro-alloy steel. The company's product portfolio includes special bar quality steel and seamless mechanical tubes, along with value-added solutions such as precision steel components. In addition to manufacturing, Metallus provides machining and thermal treatment services, and it manages raw material recycling programs that support its melting operations. Its products and services cater to a diverse range of sectors, including oil and gas, automotive, industrial equipment, mining, construction, rail, aerospace and defense, heavy truck, agriculture, and power generation.
OnStation
Series A in 2024
OnStation develops an application designed to enhance efficiency at job sites by providing immediate access to location data, project plans, and communication tools for teams. The app features an automatic station finder that allows users to quickly determine their position on the job, even in areas where survey data and project documents may be scarce. By utilizing a statewide milepost network, OnStation's technology supports smaller projects and facilitates improved connectivity among roadway workers and designers. This integration of critical job site information helps minimize worker downtime and errors, ultimately streamlining project management and fostering consistency across various tasks.
Abre
Series A in 2024
Abre develops an education management platform designed to enhance outcomes within K-12 learning communities. The platform offers a suite of applications that cover learning management, school and classroom management, data analytics, and communication tools. By integrating various software solutions, Abre enables schools to streamline their operations and manage all web-based applications through a single sign-on. This approach helps eliminate data silos and equips stakeholders with the tools necessary for effective decision-making, ultimately supporting the holistic development of students.
Cloverleaf.me
Series A in 2024
Cloverleaf LLC offers a visualization and scenario-planning platform designed to enhance team management and employee development. Founded in 2015 and based in Covington, Kentucky, the platform analyzes employee data to provide insights into team dynamics by cross-mapping personality traits, skills, and organizational culture. This enables users, including agile practitioners, project managers, and human resource professionals, to position team members effectively, improve communication, and identify suitable candidates to boost productivity. Additionally, Cloverleaf's automated coaching features deliver personalized nudges through commonly used tools like Google Workspace, Microsoft Outlook, and Slack, fostering collaboration and performance improvements within teams.
AssetWatch
Venture Round in 2024
AssetWatch specializes in proactive and predictive maintenance solutions aimed at preventing unplanned downtime for global manufacturers. The company offers an extensive remote condition monitoring service that integrates wireless sensors and communication hubs with sophisticated software. These wireless vibration and temperature sensors gather critical machine health data, which is analyzed using machine learning algorithms and the expertise of condition monitoring engineers. This analysis provides actionable insights that go beyond simple pass/fail assessments, enabling manufacturers to transition from a reactive to a proactive maintenance culture. By delivering prescriptive recommendations, AssetWatch supports manufacturers in optimizing their maintenance processes and enhancing operational reliability.
Avation Medical
Series C in 2024
Avation Medical, Inc. is focused on developing a non-invasive closed-loop neuromodulation system designed for the at-home treatment of overactive bladder. Established in 2016 and based in Columbus, Ohio, the company is pioneering wearable nerve stimulation platforms that emphasize patient empowerment and personalized care. By re-imagining neuromodulation through innovative, proven technologies, Avation Medical aims to enhance the management of chronic conditions, offering solutions that prioritize the needs and experiences of patients.
AlensiaXR
Series A in 2024
AlensiaXR is a tech startup spun out of Case Western Reserve University, specializing in an innovative learning platform called HoloAnatomy. This platform leverages advanced mixed-reality technology to project and illuminate the human body in 3D, enhancing students' understanding and retention of anatomical content. By transcending traditional classroom boundaries, AlensiaXR helps universities reduce the need for expensive and time-consuming cadaver procurement and maintenance.
Clarametyx Biosciences
Series A in 2024
Clarametyx Biosciences, Inc. is a biotechnology company based in Columbus, Ohio, focused on developing targeted and immune-enabling biologic therapies to address persistent infections linked to biofilms. Founded in 2020, the company utilizes a novel technology platform designed to penetrate the protective layers surrounding bacteria, facilitating immune responses and enhancing the effectiveness of antibiotic interventions. Among its key developments is CMTX-001, a humanized monoclonal antibody currently in preclinical stages aimed at treating hospital-acquired pneumonia. Clarametyx's innovative approach seeks to combat life-threatening infections while addressing the growing concerns of antibiotic resistance.
Society Brands
Grant in 2023
Society Brands is a tech-enabled consumer products company based in Canton, Ohio, that specializes in acquiring e-commerce native brands. Established in 2020, the company focuses on brands that primarily sell through Amazon and their own direct-to-consumer (DTC) websites. By leveraging technology, Society Brands aims to optimize the growth and performance of the brands in its portfolio, enhancing their market presence and operational efficiency.
Lentechs
Venture Round in 2023
Lentechs is a medical device company based in Columbus, Ohio, specializing in the development of innovative soft bifocal contact lenses. The company focuses on creating a new generation of soft, suspended progressive contact lenses that enhance visual clarity and comfort. These lenses are designed to allow natural eye movement, similar to the experience of wearing bifocal glasses, while minimizing irritation. Lentechs aims to provide a comprehensive range of products that address the needs of patients throughout their visual health journey.
Enspire DBS Therapy
Series B in 2023
Enspire DBS Therapy, Inc. is dedicated to developing a proprietary deep brain stimulation (DBS) therapy aimed at restoring motor function in stroke survivors with disabilities. Founded in 2010 and based in Cleveland, Ohio, the company is currently conducting a Phase I clinical trial to evaluate the effectiveness of its DBS therapy in stroke recovery. The therapy integrates deep brain stimulation with physical rehabilitation techniques, leveraging natural pathways to enhance the effects of both stimulation and therapy. This innovative approach aims to accelerate recovery for stroke patients, offering them improved access to rehabilitation and the potential for greater restoration of motor function.
Invirsa
Series B in 2023
Invirsa Inc. is a biotechnology company based in Columbus, Ohio, established in 2016. The firm focuses on developing therapeutic agents to enhance immunity and promote wound healing, with its lead compound, INV-102, at the forefront of its research. INV-102 is a naturally occurring small molecule that aims to strengthen the immune response, reduce cellular injury caused by adenovirus, and stimulate DNA repair. The compound is being explored primarily for applications in ophthalmology and pulmonary medicine, targeting conditions such as keratoconjunctivitis and upper respiratory tract infections. Invirsa's approach not only seeks to reduce inflammation and viral infections but also has the potential to serve as a first-line therapy for common infectious diseases, addressing the significant number of viral pulmonary infections and infectious conjunctivitis cases in the United States.
MediView
Venture Round in 2023
MediView, LLC is a medical device company based in Cleveland, Ohio, established in 2017. The company specializes in developing an augmented reality surgical navigation system designed to enhance the surgical process for healthcare providers. Its primary product, MediView, utilizes extended reality technology to offer real-time, fused-holographic visualization, which aids in the ablation and biopsy of cancerous tumors. This innovative approach allows surgeons to navigate procedures with greater accuracy and efficacy compared to conventional two-dimensional displays. Additionally, MediView's technology supports remote collaboration and telehealth, providing healthcare professionals with valuable insights and the ability to examine patients more effectively using three-dimensional holograms.
BIOHM Health
Seed Round in 2023
BIOHM is a pioneering microbiome company focused on enhancing digestive health by addressing the role of fungi alongside bacteria. With over 20 years of research backed by the National Institutes of Health, Dr. Ghannoum has developed a unique understanding of how harmful bacteria and fungi interact to create digestive plaque, a barrier that disrupts gut balance. BIOHM offers a range of whole probiotics and gut microbiome testing kits designed to educate consumers about their gut health. The company’s innovative products utilize dual-action technology to break down digestive plaque and neutralize harmful microorganisms, thereby promoting a balanced microbiome. By providing personalized insights into gut health, BIOHM empowers individuals to make informed choices regarding their diet, lifestyle, and supplements to optimize their digestive well-being.
Genetesis
Series C in 2022
Genetesis LLC is a medical technology company based in Mason, Ohio, that specializes in biomagnetic imaging solutions to improve patient diagnosis and monitoring of cardiac conditions. Founded in 2013, the company has developed the Genetesis CardioFlux, a mapping system designed to enhance the detection and treatment of cardiac rhythm disorders by visualizing the heart's electrical currents in three dimensions. Additionally, Genetesis offers the Faraday Analytical Cloud, a HIPAA-compliant platform that manages the data workflow for the CardioFlux magnetocardiograph. The system is non-invasive and avoids exposing patients to radiation or requiring exercise, enabling clinicians to accurately measure the magnetic signals generated by the heart during its electrical activity.
Guided By Mushrooms
Grant in 2022
Guided By Mushrooms is an urban mushroom farm specializing in gourmet mushrooms, mycology products, mycological landscaping, and more.
Drive My Way
Venture Round in 2022
Drive My Way, Inc. operates an online recruitment platform specifically designed for the trucking industry, connecting commercial truck drivers with employers seeking qualified candidates. Founded in 2014 and headquartered in Chagrin Falls, Ohio, the platform enables employers to post job listings that reflect specific attributes while allowing drivers to create profiles based on their qualifications and lifestyle preferences. Utilizing proprietary matching technology, Drive My Way filters job opportunities based on various factors such as schedule, location, and benefits, ensuring a personalized job match. This approach not only assists drivers in finding positions that align with their needs but also helps employers identify the right candidates efficiently, thereby reducing recruitment costs and turnover rates. Additionally, the platform features a content portal that provides industry news and networking opportunities for its members.
Cionic
Series A in 2022
Cionic, Inc. is a technology company based in San Francisco, California, that specializes in developing wearable solutions aimed at enhancing human performance and quality of life. Founded in 2018, Cionic focuses on creating precision bionics, including neural sleeves, that provide comprehensive analysis and precise augmentation to help individuals overcome physical limitations. Their products integrate advanced hardware, software, and algorithms, emphasizing functional wearability and personalized intelligence. By addressing the adverse effects of physical ailments, Cionic aims to empower users to improve their functionality and overall performance.
OvationCXM
Series C in 2022
OvationCXM is a provider of customer experience management solutions that enables enterprises to enhance their customer journeys across various touchpoints, including digital, back-office, and partner interactions. The platform integrates journey orchestration, knowledge management, generative AI, dynamic chat, and partner connectivity, offering a comprehensive approach to identifying and addressing friction points in real time. This capability helps businesses secure revenue, drive profitable growth, and improve customer loyalty while also supporting staff retention. With features such as pre-built CRM connectors and automation tools, OvationCXM equips clients with the visibility and control needed to deliver exceptional customer experiences efficiently.
Centerline Biomedical
Series B in 2022
Centerline Biomedical, Inc. is a Cleveland-based company founded in 2014, focused on developing advanced navigation systems for interventional vascular procedures. The company specializes in a non-x-ray based, three-dimensional GPS surgical navigation technology that enhances the precision and outcomes of endovascular procedures while significantly reducing radiation exposure for both patients and healthcare providers. This innovative system assists surgeons in accurately navigating catheters and guide wires through the complex three-dimensional anatomy of patients with vascular diseases, ultimately enabling safer and more effective image-guided surgeries. The technology is rooted in research and development from the Cleveland Clinic, highlighting its commitment to improving surgical practices in the medical field.
AssetWatch
Series A in 2022
AssetWatch specializes in proactive and predictive maintenance solutions aimed at preventing unplanned downtime for global manufacturers. The company offers an extensive remote condition monitoring service that integrates wireless sensors and communication hubs with sophisticated software. These wireless vibration and temperature sensors gather critical machine health data, which is analyzed using machine learning algorithms and the expertise of condition monitoring engineers. This analysis provides actionable insights that go beyond simple pass/fail assessments, enabling manufacturers to transition from a reactive to a proactive maintenance culture. By delivering prescriptive recommendations, AssetWatch supports manufacturers in optimizing their maintenance processes and enhancing operational reliability.
SHARE Mobility
Series A in 2022
SHARE Mobility specializes in providing transportation solutions tailored for companies, aimed at addressing the mobility challenges faced by frontline workers. The company offers a comprehensive transit planning software that includes features such as planning, simulation, on-demand micro-transit, and routing. This integrated approach facilitates multi-modal transit and mobility management, enabling enterprises and transit operators to improve employee retention and fill open jobs by offering reliable transportation as a benefit. SHARE Mobility's focus on sustainable and safe transportation solutions empowers brands and employers to support their workforces and communities effectively.
Cloverleaf.me
Series A in 2022
Cloverleaf LLC offers a visualization and scenario-planning platform designed to enhance team management and employee development. Founded in 2015 and based in Covington, Kentucky, the platform analyzes employee data to provide insights into team dynamics by cross-mapping personality traits, skills, and organizational culture. This enables users, including agile practitioners, project managers, and human resource professionals, to position team members effectively, improve communication, and identify suitable candidates to boost productivity. Additionally, Cloverleaf's automated coaching features deliver personalized nudges through commonly used tools like Google Workspace, Microsoft Outlook, and Slack, fostering collaboration and performance improvements within teams.
XII Medical
Series A in 2022
XII Medical is a medical device developer focused on creating innovative solutions for obstructive sleep apnea. The company has developed a minimally invasive outpatient technology that includes an implantable neurostimulation device designed to alleviate the condition. This device works by preventing the muscles in the throat from relaxing during sleep, thereby avoiding airway blockage and enabling patients to enhance oropharyngeal airflow. Through its advancements in sleep apnea treatment, XII Medical aims to improve patient outcomes and provide a proactive approach to managing this common sleep disorder.
Orthobrain
Series A in 2022
Orthobrain offers an orthodontic growth system that enables general dentists to incorporate orthodontic services into their practices effectively. By leveraging digital technology, proprietary AI-driven learning systems, and expert mentorship, Orthobrain provides a comprehensive solution that supports dentists from patient acquisition through to treatment. Their offerings include the SimplyClear aligner system, which helps patients achieve straighter smiles while providing extensive clinical support through access to U.S.-based orthodontic experts. The platform also features clinical mentoring, treatment planning, and on-demand support, facilitating the integration of pediatric dentistry, braces, and aligner treatments into dental practices. In recognition of its innovative approach, SimplyClear was awarded the Product of the Year in 2024 by a national dental distributor.
Rhyme
Venture Round in 2022
PriorAuthNow, Inc. is a software company based in Columbus, Ohio, established in 2014. The company specializes in developing solutions that facilitate the submission, monitoring, and completion of insurance prior authorization requests for medical providers. Its flagship product, PriorAuthNow, integrates with electronic health record systems and connects directly with insurance carriers, streamlining the prior authorization process. By serving a diverse range of clients, including hospitals, surgery centers, drug manufacturers, and other healthcare organizations, PriorAuthNow aims to enhance patient care access and improve the overall healthcare experience. The company focuses on creating a seamless workflow that empowers medical providers and their staff, ultimately driving patient satisfaction and transforming healthcare delivery.
Prevedere
Venture Round in 2022
Prevedere, Inc. is a predictive analytics company that specializes in business performance forecasting software. Founded in 2012 and headquartered in Columbus, Ohio, with an additional office in Sunnyvale, California, Prevedere provides a range of services including industry outlook reports, consumer behavior data, and predictive insights. The company's platform helps businesses monitor economic, environmental, and consumer behavior data to identify leading indicators for revenue and profit, thereby aiding in informed decision-making. Prevedere's offerings include predictive marketing analytics, financial forecasting intelligence, and demand planning solutions. The company also develops proprietary systems and APIs that integrate diverse data sources to ensure data accuracy and relevance. With a team comprising industry experts, data scientists, and economists, Prevedere supports organizations in navigating an ever-evolving market landscape.
Valley Foods
Debt Financing in 2021
Valley Foods is a family-owned food-service company based in Annville, Pennsylvania. The company specializes in providing grocery products and has developed an innovative zero-waste A-Rations program, specifically serving The National Guard. This program reflects Valley Foods' commitment to sustainability and efficiency in food service. Through its operations, the company aims to meet the needs of its clients while minimizing environmental impact.
Aware
Series C in 2021
Aware is a cloud intelligence platform that leverages advancements in cognitive computing, artificial intelligence, and behavioral analytics to enhance enterprise value through social graph monitoring. The company provides governance, compliance, and monitoring solutions aimed at improving connectivity, collaboration, and security within organizations. Their platform addresses challenges faced by legal, compliance, information security, and IT departments, offering tools for archiving, monitoring, organizational insights, data loss prevention, eDiscovery, retention, and legal holds. By harnessing insights into human behavior and interactivity, Aware aims to improve employee engagement while minimizing the risk of unsafe behavior in the workplace.
Eikonoklastes Therapeutics
Series A in 2021
Eikonoklastes Therapeutics, Inc. is a biopharmaceutical company based in Cincinnati, Ohio, focused on developing innovative immunotherapies for diseases with significant unmet clinical needs. Since its incorporation in 2019, the company has established a pipeline of new therapies aimed at advancing from preclinical stages to clinical proof-of-concept efficiently and affordably. Its lead product, ET-101, is a gene therapy engineered to enhance the expression of Caveolin-1, which plays a critical role in neuromuscular signaling and aims to treat various neurodegenerative diseases. Additionally, Eikonoklastes is developing ET-201, a novel tissue factor therapy designed to target proteins prevalent in solid tumors, including triple-negative breast cancer and metastatic melanoma, while sparing normal cells. By addressing conditions such as ALS and cancers with high mortality, Eikonoklastes seeks to provide effective treatment solutions where current options are lacking. The company plans to expand its pipeline to include further indications with inadequate treatment alternatives, such as Alzheimer’s and Parkinson’s diseases.
DAtAnchor
Convertible Note in 2021
Traditional IT controls focus on locking down networks, devices, and people. All of this is done in the name of protecting data. But, once files are moved, shared, or stolen, the data is no longer protected. Even worse, these controls get in the way and frustrate business users to the point they intentionally work around them. Anchor inverts the equation by baking protection into the data, invisible to the business users (like antivirus), so that files are free to travel and security is out of the way. Simply put, wherever the data goes, it is protected. Anchor is a SaaS platform, with an endpoint component, that bakes protection into your files with a unique transparent combination of encryption, continuous multi-factor access controls, and a digital chain of custody. And when you do share or collaborate, Anchor protection stays with your data, even when it leaves your organization. Anchor empowers you to maintain control of your files while collaborating on premise or in the cloud, including forensic logging and revoking access. In under 90 minutes, Anchor is fully deployed and empowers your business users to securely work and collaborate without complicated security products or rules in the way. All without requiring you to change existing IT controls or how your users and applications work today. DAtAnchor is a result of a multi-year research activity, developed at Ohio State University. The development team currently has 6 members, 4 of which are full-time. We have seed level funding for >1M and an advisory board with members at the senior vice president level in Fortune 500 companies.
S4 Medical
Series A in 2021
S4 Medical, established in 2017 and headquartered in Cleveland, Ohio, specializes in manufacturing medical devices for catheter ablation treatment of atrial fibrillation. Its primary product, the eSolution device, is designed to minimize complications to the esophagus during these procedures.
Aware
Series B in 2020
Aware is a cloud intelligence platform that leverages advancements in cognitive computing, artificial intelligence, and behavioral analytics to enhance enterprise value through social graph monitoring. The company provides governance, compliance, and monitoring solutions aimed at improving connectivity, collaboration, and security within organizations. Their platform addresses challenges faced by legal, compliance, information security, and IT departments, offering tools for archiving, monitoring, organizational insights, data loss prevention, eDiscovery, retention, and legal holds. By harnessing insights into human behavior and interactivity, Aware aims to improve employee engagement while minimizing the risk of unsafe behavior in the workplace.
Abre
Seed Round in 2020
Abre develops an education management platform designed to enhance outcomes within K-12 learning communities. The platform offers a suite of applications that cover learning management, school and classroom management, data analytics, and communication tools. By integrating various software solutions, Abre enables schools to streamline their operations and manage all web-based applications through a single sign-on. This approach helps eliminate data silos and equips stakeholders with the tools necessary for effective decision-making, ultimately supporting the holistic development of students.
Ohio Valley Bank
Grant in 2019
Ohio Valley Bank is a full-service financial institution headquartered in Southeastern Ohio, also serving western West Virginia. It offers a comprehensive range of banking services, including checking and savings accounts, trust services, and various types of loans such as personal, commercial, and real estate loans. The bank also provides specialized services like VA loans, vehicle loans, and student loans, as well as home loan options. In addition to traditional banking products, Ohio Valley Bank offers individual retirement accounts, safe deposit boxes, and wire transfers, ensuring a wide array of financial solutions for both individual and business clients.
Transportation Research Center
Grant in 2017
Transportation Research Center (TRC Inc.) specializes in research and development testing services. Brakes, crashworthiness, emissions, durability, fuel economy, handling, driver training classes, and performance testing is conducted at the independent automotive proving ground. Facilities include a 7.5 mile (12.1 km) test track, 50-acre (20 hectare) vehicle dynamics area, 9,000 ft. x 84 ft. (2723 x 25 m) skid pad, wet basalt and tile surfaces, emissions lab, dynamic handling courses, off-highway area, and crash test barrier and simulator sled.
Ahalogy
Series B in 2015
Ahalogy, now part of Quotient, operates as a digital marketing platform focused on connecting brands with consumers through their interests. It provides services that include category trend data, authentic influencer content, and social optimization technology. This enables brands and agencies to enhance user engagement and drive sales by leveraging proven return on investment strategies. Ahalogy is recognized as an official Pinterest Marketing Partner and collaborates with other major social networks to optimize marketing efforts. Headquartered in Cincinnati, Ohio, Ahalogy also maintains offices in New York, Chicago, Los Angeles, and San Francisco, positioning itself in key markets for brand marketing.
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