JumpStart

JumpStart Inc., established in 2003, is a Cleveland, Ohio-based non-profit organization dedicated to fostering economic growth through entrepreneurship. It provides intensive support to early-stage, high-potential companies in Ohio, focusing on minority and women entrepreneurs. Additionally, JumpStart collaborates with regional leaders to strengthen Ohio's entrepreneurial ecosystem and attract resources for entrepreneurs. Its investment arm, Jumpstart Ventures, focuses on early-stage venture capital, primarily in the healthcare device and supply sectors.

Tamika Otis

Director, KeyBank Business Boost and Build NY

165 past transactions

Spokbee

Grant in 2025
Spokbee is a company that specializes in advanced manufacturing technology and software solutions, focusing on a 3D product configuration platform. This platform is designed to facilitate the sale of custom-manufactured products by automating product configurators and streamlining sales processes. By enhancing manufacturing efficiency, Spokbee enables clients to easily obtain personalized gifts, unique home decor, and customized industrial supplies, all from a single source. The company's innovative approach allows for greater customization and convenience in the manufacturing sector.

Asynt Solutions

Seed Round in 2024
Asynt Solutions, founded in 2021 and headquartered in Columbus, Ohio, specializes in developing innovative and efficient solutions for transportation infrastructure and construction. The company focuses on providing advanced traffic barrier systems designed to enhance safety and efficiency in these sectors. Their products are engineered from composite materials that are significantly lighter—approximately eighty percent lighter than traditional concrete barriers—while also being capable of absorbing more energy during impacts. This design not only improves safety but also facilitates faster installation and removal, ultimately reducing maintenance costs for businesses.

NavAgentic

Seed Round in 2023
NavAgentic is all-in-one resource to find jobs and build your skills.

Callisto Terra

Grant in 2023
Callisto Terra is a handmade candle company that provides candle products and candle-making classes to the users.

Lavish Me by Adore

Grant in 2023
Lavish Me by Adore LLC is a day spa that is locally owned and operated and offers a wide range of aesthetic services. Lavish is an IV Hydration and Aesthetics Clinic that specializes in IV drips, waxing, and skincare.

OUCH! Massage Therapy

Grant in 2023
OUCH! Massage Therapy is a one-of-a-kind pain management option that provides individuals suffering from chronic pain with natural relief.

Kid-N-Play Daycare and Learning Center

Grant in 2023
At Kid-N-Play Daycare and Learning Center our mission is to focus on the individual needs of each child, while providing quality, reliable and safe child care. We offer the opportunity for each child to develop physically, socially and cognitively according to their individual learning style.

Cake Library

Grant in 2023
Cake Library focuses in creating baked goods that are dye- and gluten-free as well as other allergy-friendly products. Regardless of dietary requirements, everyone may enjoy the distinctive experience that their collection of cakes and delicacies offers.

BIOHM Health

Seed Round in 2023
BIOHM Health is a pioneering company in the field of microbiome research, focusing on the role of fungi in digestive health. Founded by Dr. Mahmoud Ghannoum, who has conducted over 20 years of NIH-supported research, BIOHM offers whole probiotics and gut microbiome testing kits. The company's innovative approach targets digestive plaque, a destructive film formed by bad bacteria and fungi that disrupts the natural balance of the digestive system. BIOHM's dual-action technology breaks down this plaque and neutralizes harmful microorganisms, promoting optimal digestive health. Their products provide consumers with insights into their gut health and personalized recommendations for diet, lifestyle, and supplements to support overall well-being.

Intus Care

Series A in 2022
Intus Care, Inc. is a healthcare analytics company that specializes in connecting home care providers with patients through its innovative platform. Founded in 2018 and based in North Providence, Rhode Island, the company leverages machine learning and electronic health records to enhance the efficiency of care delivery. Its application enables provider organizations to conduct electronic visit verification and predict hospital readmissions and utilization risks. Additionally, Intus Care's platform facilitates automatic patient risk grouping and tracking, identifies patients at high risk for hospitalization, and sends alerts regarding changes in patient health status to care coordination teams. By synthesizing financial, clinical, and administrative data, Intus Care helps healthcare organizations, including PACE programs and long-term care facilities, visualize trends and implement data-driven interventions aimed at improving patient care and reducing hospitalizations for vulnerable populations.

NavAgentic

Seed Round in 2022
NavAgentic is all-in-one resource to find jobs and build your skills.

SHARE Mobility

Series A in 2022
SHARE Mobility is a provider of transportation solutions aimed at enhancing employee retention and filling open jobs by offering transportation as a benefit. The company has developed a transit planning software that addresses transportation barriers faced by frontline workers. This software includes features such as integrated mobility planning, simulation, on-demand micro-transit, routing, and a mobility data exchange. By delivering comprehensive multi-modal transit and mobility management solutions, SHARE Mobility enables brands and employers to equip their workforces and communities with reliable transportation options, thereby improving access to employment opportunities.

Oko

Seed Round in 2022
Oko helps supply chain managers make better decisions

TonDone

Seed Round in 2022
TonDone is a developer of management software tailored for buildings and facility service organizations. The company's all-in-one application enhances task management by providing notifications, updating tasks, and managing workflows. This functionality aims to boost productivity and efficiency, ultimately helping users retain customers and increase sales. By simplifying enterprise operations, TonDone enables managers to streamline their processes and improve revenue generation.

NeverEnding

Pre Seed Round in 2022
NeverEnding is a content creation platform founded in 2020 and based in Cleveland, Ohio. The company specializes in avatar creation software designed for gaming and social media, providing creators and teams with tools to bring their stories and imagination to life. NeverEnding's platform facilitates the development of characters for various applications, including tabletop gaming, streaming, webcomics, and animated videos. By offering intuitive and convenient tools, the company enables users to create and share their content while connecting with others who share similar interests, thus enhancing the overall storytelling and gaming experience.

Orthobrain

Series A in 2022
Orthobrain is a company that facilitates the integration of orthodontic services into general dental practices through a comprehensive growth system. It utilizes digital technology, proprietary AI-driven learning systems, and expert mentorship to enhance the capabilities of dentists and improve their clinical confidence. Orthobrain provides various orthodontic solutions, including the SimplyClear aligner system, which offers an effective option for patients seeking straighter smiles. The company ensures comprehensive clinical support by granting access to U.S.-based orthodontic experts. In 2024, the SimplyClear aligner system received recognition as the Product of the Year from Benco, a notable national dental distributor. Through its platform, Orthobrain delivers clinical mentoring, treatment planning, and on-demand support, enabling dental professionals to confidently incorporate orthodontic care into their services.

Wizest

Pre Seed Round in 2021
Wizest is an innovative trading platform designed to democratize access to the stock market by allowing users to invest like top financial experts. The company enables individuals to form teams of financial advisors based on their preferences and values. Users can copy the portfolios of these experts, who are selected from performance leaderboards, and learn from their investment strategies through a news feed. Wizest aims to provide an engaging and educational experience by gamifying the investing process, making it accessible for everyone to diversify their investment strategies.

Aware

Series C in 2021
Aware is a cloud intelligence platform that leverages advancements in cognitive computing, artificial intelligence, and behavioral analytics to enhance enterprise value through social graph monitoring. The company provides governance, compliance, and monitoring solutions aimed at improving connectivity, collaboration, and security within organizations. Their platform addresses challenges faced by legal, compliance, information security, and IT departments, offering tools for archiving, monitoring, organizational insights, data loss prevention, eDiscovery, retention, and legal holds. By harnessing insights into human behavior and interactivity, Aware aims to improve employee engagement while minimizing the risk of unsafe behavior in the workplace.

Renalis

Pre Seed Round in 2021
Renalis is a digital health company that specializes in developing innovative platforms aimed at enhancing the management of pelvic health conditions. Its technology addresses issues related to urinary incontinence, overactive bladder, and abnormal uterine bleeding. By focusing on increasing patient engagement and improving adherence to treatment protocols, Renalis seeks to optimize health outcomes for individuals facing these challenges. The company's solutions are designed to minimize the out-migration of patients from care, thereby conserving valuable time and resources for healthcare providers. Through its commitment to improving pelvic health, Renalis aims to support individuals throughout their life course.

OnStation

Seed Round in 2021
OnStation is a technology company that develops a mobile application designed to enhance job site efficiency for construction and roadway projects. The app provides instant access to job site locations, project plans, and a communication platform for teams, facilitating better collaboration among workers. Its key feature, the Station Finder, allows users to quickly identify their location on the job site, utilizing a statewide milepost network for added convenience. By streamlining access to critical data and reducing downtime and potential errors, OnStation aims to improve project management and ensure consistency across various construction tasks, particularly on smaller jobs where traditional survey data may be limited.

Axuall

Series A in 2021
Axuall, Inc. is a workforce intelligence company headquartered in Cleveland, Ohio, that provides a digital network for verifying identity, credentials, and authenticity across various sectors, including healthcare, insurance, and logistics. Established in 2018, Axuall focuses on enhancing workforce analytics through a real-time practitioner data network, enabling healthcare systems, staffing firms, and telehealth organizations to streamline processes such as onboarding, credentialing, and enrollment. The company's integrated platform facilitates smarter decision-making and reduces the time required to onboard healthcare providers. By empowering professionals with control over their career identity, Axuall offers unique insights for network planning and analytics, ultimately driving efficiencies and maximizing revenue for its clients.

Checkpoint Surgical

Venture Round in 2021
Checkpoint Surgical Inc., established in 2009 and headquartered in Cleveland, Ohio, specializes in manufacturing neuro devices for surgeons. Their primary products are CHECKPOINT 9094 and CHECKPOINT 9394, both designed to locate, identify, and evaluate motor nerve tissue and muscle function during complex surgical procedures. These devices cater to various applications such as head and neck surgeries, hand and extremities procedures, targeted muscle re-innervation, orthopedic oncology and trauma, and plastic reconstruction. The company sells its products through a network of distributors in the United States, aiming to enhance patient outcomes by providing surgeons with precise nerve stimulation and monitoring equipment.

S4 Medical

Series A in 2021
S4 Medical Corp is a medical device company specializing in innovations for catheter ablation treatment of atrial fibrillation. Founded in 2017 and based in Cleveland, Ohio, S4 Medical has developed an eSolution device that aims to reduce complications to the esophagus during ablation procedures. This device provides an effective means for electrophysiologists to protect the esophagus and strategically determine when and where to deviate it, thereby minimizing the risk of thermal injury associated with these cardiac interventions. The company's focus on enhancing safety during atrial fibrillation treatments underscores its commitment to improving patient outcomes in the field of cardiology.

Aware

Series B in 2020
Aware is a cloud intelligence platform that leverages advancements in cognitive computing, artificial intelligence, and behavioral analytics to enhance enterprise value through social graph monitoring. The company provides governance, compliance, and monitoring solutions aimed at improving connectivity, collaboration, and security within organizations. Their platform addresses challenges faced by legal, compliance, information security, and IT departments, offering tools for archiving, monitoring, organizational insights, data loss prevention, eDiscovery, retention, and legal holds. By harnessing insights into human behavior and interactivity, Aware aims to improve employee engagement while minimizing the risk of unsafe behavior in the workplace.

7SIGNAL

Series D in 2020
7SIGNAL is an enterprise wireless experience monitoring company that offers a cloud-based platform designed to continuously assess wireless networks and identify performance issues affecting application functionality. By employing an "outside-in" monitoring approach, the platform provides visibility at the edge of both enterprise and home Wi-Fi networks, where user experience is critical. This capability enhances employee productivity, operational efficiency, and network return on investment. Targeted towards innovative organizations, educational institutions, healthcare systems, and government entities, 7SIGNAL's system is utilized by Fortune 500 companies, hospitals, and large venues worldwide. It simplifies the management of business-critical wireless LANs, reduces total ownership costs, and facilitates quicker problem resolution, particularly in remote environments, without the need to add extra wireless access points.

ReadySet Surgical

Series A in 2020
ReadySet Surgical LLC is a company based in Cincinnati, Ohio, that specializes in cloud-based software solutions for managing surgical vendor inventory. The platform enhances coordination and communication among surgical teams, sterilization departments, and medical device vendors, ensuring that every procedure is equipped with the correct contracted inventory and documentation. ReadySet Surgical also offers RS Analyze, a tool for hospitals to evaluate vendor performance and detect off-contract implant purchases through real-time data analytics, allowing for timely corrective actions. The company focuses on providing a user-friendly experience and seamless installation for hospital staff and vendor representatives. Established in 2014, ReadySet Surgical aims to improve the efficiency and transparency of the surgical supply chain, ultimately reducing delays and errors in surgical procedures.

S4 Medical

Venture Round in 2020
S4 Medical Corp is a medical device company specializing in innovations for catheter ablation treatment of atrial fibrillation. Founded in 2017 and based in Cleveland, Ohio, S4 Medical has developed an eSolution device that aims to reduce complications to the esophagus during ablation procedures. This device provides an effective means for electrophysiologists to protect the esophagus and strategically determine when and where to deviate it, thereby minimizing the risk of thermal injury associated with these cardiac interventions. The company's focus on enhancing safety during atrial fibrillation treatments underscores its commitment to improving patient outcomes in the field of cardiology.

Able (formerly EmployStream)

Series B in 2020
EmployStream is a hiring workflow automation software platform for staffing companies and other high-volume employers. It also creates high-quality, user-friendly for high-volume employers that automates the hiring and onboarding process for employers. The platform eliminates costly mistakes and delays allowing companies to hire up to 90% faster and at half the cost. The company provides an online hiring platform which offers different features such as paper onboarding, real-time alerting, online application, background checks, applicant pre & interview screening, and verification. EmployStream was founded in 2014 and is headquartered in Cleveland Ohio, USA.

SoLo

Seed Round in 2019
SoLo Funds, Inc., established in 2015 and headquartered in New York City, operates a mobile platform that facilitates peer-to-peer lending. It connects individuals in need of short-term loans with those willing to lend, fostering a community-driven financial ecosystem. The platform assesses creditworthiness and enables borrowers to access small, interest-free loans on terms they set, processing millions of transactions since its 2018 launch. SoLo aims to provide an equitable and empowering lending alternative, and is expanding its services to include banking, credit building, and premium member offerings.

MedPilot

Seed Round in 2019
MedPilot Inc. is a Cleveland-based company that offers an AI-driven patient relationship management platform, established in 2014. The company specializes in addressing administrative and billing challenges within the healthcare sector. MedPilot provides a payment platform that simplifies the verification process for patients, clearly explaining their financial obligations. Additionally, it enhances the patient experience through post-payment surveys that gather valuable feedback for healthcare providers. The platform includes a network of patient navigators who assist in managing medical payments, offering billing discounts and customizable payment plans. By focusing on advocacy services, MedPilot aims to resolve payment issues and optimize the overall patient experience in the healthcare community.

Vitalxchange

Pre Seed Round in 2019
Vitalxchange, Inc. is a company based in North Royalton, Ohio, that develops a holistic virtual platform designed to support parents of children with autism and developmental disabilities. Incorporated in 2018, the platform combines human expertise with a proprietary expert system to assist families in navigating the complexities of their child's developmental, behavioral, and learning needs. Each family is paired with a team of VitalGuides who offer comprehensive support throughout the parenting journey, helping to identify issues early and facilitating connections with clinical or educational providers for diagnosis and treatment. The platform covers a range of topics, from picky eating to behavior management and disability planning, and is accessible through a subscription model available directly from the Vitalxchange website or via employer benefits programs.

Able (formerly EmployStream)

Series A in 2019
EmployStream is a hiring workflow automation software platform for staffing companies and other high-volume employers. It also creates high-quality, user-friendly for high-volume employers that automates the hiring and onboarding process for employers. The platform eliminates costly mistakes and delays allowing companies to hire up to 90% faster and at half the cost. The company provides an online hiring platform which offers different features such as paper onboarding, real-time alerting, online application, background checks, applicant pre & interview screening, and verification. EmployStream was founded in 2014 and is headquartered in Cleveland Ohio, USA.

enosiX

Series B in 2018
enosiX, Inc. is a technology company that specializes in real-time integration solutions connecting Salesforce with SAP systems. Founded in 2014 and based in Cincinnati, Ohio, enosiX develops a range of products that facilitate seamless data exchange and enhance business processes. Key offerings include Enosix Connect, which integrates SAP/ERP systems with cloud applications, and Enosix Engage, which enables direct access to SAP ERP data within Salesforce without the need for middleware. The company's platform empowers Salesforce users with essential information such as customer data, inventory, and order management, all in real-time. This integration allows organizations to improve productivity, increase sales effectiveness, and enhance customer engagement. Additionally, enosiX provides mobile solutions for various business functions, ensuring that critical SAP data is accessible to an increasingly mobile workforce. With a focus on reducing integration time from months to days, enosiX enhances operational efficiency and drives better business outcomes.

Bezlio

Venture Round in 2018
Bezlio enhances manufacturing shop floor productivity and efficiency. It is a saas product that allows their mobile workforce to visualize their data and analytics from anywhere, on any device.

Mezu

Venture Round in 2018
Mezu, Inc. is a banking technology company based in Cleveland Heights, Ohio, incorporated in 2017. It operates a mobile payment application that enables users to send and receive money privately and securely, without the need to share personal information. The app facilitates cash-like transactions, allowing users to pay, tip, earn, and donate without incurring fees. Available on both iOS and Android platforms in the United States, Mezu prioritizes user privacy, emphasizing that financial activities should remain confidential.

S4 Medical

Seed Round in 2018
S4 Medical Corp is a medical device company specializing in innovations for catheter ablation treatment of atrial fibrillation. Founded in 2017 and based in Cleveland, Ohio, S4 Medical has developed an eSolution device that aims to reduce complications to the esophagus during ablation procedures. This device provides an effective means for electrophysiologists to protect the esophagus and strategically determine when and where to deviate it, thereby minimizing the risk of thermal injury associated with these cardiac interventions. The company's focus on enhancing safety during atrial fibrillation treatments underscores its commitment to improving patient outcomes in the field of cardiology.

7SIGNAL

Series C in 2018
7SIGNAL is an enterprise wireless experience monitoring company that offers a cloud-based platform designed to continuously assess wireless networks and identify performance issues affecting application functionality. By employing an "outside-in" monitoring approach, the platform provides visibility at the edge of both enterprise and home Wi-Fi networks, where user experience is critical. This capability enhances employee productivity, operational efficiency, and network return on investment. Targeted towards innovative organizations, educational institutions, healthcare systems, and government entities, 7SIGNAL's system is utilized by Fortune 500 companies, hospitals, and large venues worldwide. It simplifies the management of business-critical wireless LANs, reduces total ownership costs, and facilitates quicker problem resolution, particularly in remote environments, without the need to add extra wireless access points.

Aware

Series A in 2018
Aware is a cloud intelligence platform that leverages advancements in cognitive computing, artificial intelligence, and behavioral analytics to enhance enterprise value through social graph monitoring. The company provides governance, compliance, and monitoring solutions aimed at improving connectivity, collaboration, and security within organizations. Their platform addresses challenges faced by legal, compliance, information security, and IT departments, offering tools for archiving, monitoring, organizational insights, data loss prevention, eDiscovery, retention, and legal holds. By harnessing insights into human behavior and interactivity, Aware aims to improve employee engagement while minimizing the risk of unsafe behavior in the workplace.

Wisr

Seed Round in 2017
Wisr Inc. operates an online platform that enhances alumni engagement and student outcomes for higher education institutions. Founded in 2016 and based in Rocky River, Ohio, Wisr facilitates digital coaching by connecting current students with alumni, allowing for personalized guidance in career development. Its platform supports career services and alumni relations offices by automating the matching process, scheduling, and follow-up communications. This approach enables students to build a personal board of advisors, fostering meaningful connections that can positively influence their career paths.

CompanionLabs

Seed Round in 2017
CompanionLabs is a software development company focused on creating an advertising platform that empowers brands and agencies worldwide to leverage data-driven marketing strategies. With over 50 years of combined experience, the company specializes in providing tools that enable businesses to advertise effectively on social media and enhance their marketing performance. Its platform offers simple, bite-sized companion applications that assist clients in making informed decisions, analyzing their advertising efforts, and automating performance improvements. Through its innovative solutions, CompanionLabs aims to help clients optimize their advertising strategies and achieve measurable results in a competitive digital landscape.

Komae

Angel Round in 2017
Komae, Inc. is an application-based platform founded in 2015 and headquartered in Akron, Ohio, that facilitates the exchange of babysitting services among parents within their personal networks. The app enables users to create trusted social connections with friends and family to trade babysitting hours using a point system. With over 12,500 accounts created, Komae allows parents to manage child care more flexibly by scheduling playdates and coordinating care without financial transactions. The company operates on the principle that community support is vital for parenting, as reflected in its name, which means "village" in Greek. Komae aims to expand its services beyond child care to include pet sitting, carpooling, and elder care, fostering a broader communal sharing platform.

Able (formerly EmployStream)

Series A in 2017
EmployStream is a hiring workflow automation software platform for staffing companies and other high-volume employers. It also creates high-quality, user-friendly for high-volume employers that automates the hiring and onboarding process for employers. The platform eliminates costly mistakes and delays allowing companies to hire up to 90% faster and at half the cost. The company provides an online hiring platform which offers different features such as paper onboarding, real-time alerting, online application, background checks, applicant pre & interview screening, and verification. EmployStream was founded in 2014 and is headquartered in Cleveland Ohio, USA.

Vlipsy

Seed Round in 2017
Vlipsy, Inc. is a company that operates a platform for sharing short, sound-enabled video clips, allowing users to search, watch, and create clips from a variety of sources, including movies, television shows, and internet memes. Founded in 2017 and based in Canton, Ohio, Vlipsy distinguishes itself by providing conversational video clips that can be easily integrated into online communication, similar to how GIFs are used for looping images. The platform offers users the ability to share personalized clips through a mobile application, enhancing digital conversations. Additionally, Vlipsy supports third-party integrations through its API, enabling seamless use in popular communication tools like Slack, Skype, and Telegram.

Able (formerly EmployStream)

Seed Round in 2017
EmployStream is a hiring workflow automation software platform for staffing companies and other high-volume employers. It also creates high-quality, user-friendly for high-volume employers that automates the hiring and onboarding process for employers. The platform eliminates costly mistakes and delays allowing companies to hire up to 90% faster and at half the cost. The company provides an online hiring platform which offers different features such as paper onboarding, real-time alerting, online application, background checks, applicant pre & interview screening, and verification. EmployStream was founded in 2014 and is headquartered in Cleveland Ohio, USA.

Neuros Medical

Series A in 2017
Neuros Medical, Inc. is a neuromodulation company dedicated to developing innovative therapies to address unmet medical needs for patients globally. Founded in 2008 and headquartered in Willoughby Hills, Ohio, the company specializes in its proprietary platform technology known as Electrical Nerve Block. This technology is designed to eliminate chronic pain across various conditions, including neuroma/residual limb pain, chronic post-surgical pain, and chronic migraine. The Neuros Altius System, one of its key products, includes an implantable generator with an integrated rechargeable battery, a cuff electrode, and external devices, further demonstrating the company's commitment to advancing pain management solutions.

Heureka Software

Seed Round in 2017
Heureka Software is a developer of an enterprise intelligence platform designed to address the challenges of managing unstructured data across various environments. The company's tools facilitate efficient search and management of data stored on network file systems, servers, virtual machines, laptops, and desktops. Heureka's platform provides real-time access to unstructured data, enabling organizations to respond effectively to eDiscovery requests and comply with GDPR and other privacy regulations. Additionally, it supports the automation of information governance policies, helping users classify and manage electronically stored information for litigation and regulatory compliance. Through its innovative solutions, Heureka Software empowers organizations to gain greater control over their data assets.

Aware

Series A in 2017
Aware is a cloud intelligence platform that leverages advancements in cognitive computing, artificial intelligence, and behavioral analytics to enhance enterprise value through social graph monitoring. The company provides governance, compliance, and monitoring solutions aimed at improving connectivity, collaboration, and security within organizations. Their platform addresses challenges faced by legal, compliance, information security, and IT departments, offering tools for archiving, monitoring, organizational insights, data loss prevention, eDiscovery, retention, and legal holds. By harnessing insights into human behavior and interactivity, Aware aims to improve employee engagement while minimizing the risk of unsafe behavior in the workplace.

Wisr

Seed Round in 2017
Wisr Inc. operates an online platform that enhances alumni engagement and student outcomes for higher education institutions. Founded in 2016 and based in Rocky River, Ohio, Wisr facilitates digital coaching by connecting current students with alumni, allowing for personalized guidance in career development. Its platform supports career services and alumni relations offices by automating the matching process, scheduling, and follow-up communications. This approach enables students to build a personal board of advisors, fostering meaningful connections that can positively influence their career paths.

SoLo

Convertible Note in 2017
SoLo Funds, Inc., established in 2015 and headquartered in New York City, operates a mobile platform that facilitates peer-to-peer lending. It connects individuals in need of short-term loans with those willing to lend, fostering a community-driven financial ecosystem. The platform assesses creditworthiness and enables borrowers to access small, interest-free loans on terms they set, processing millions of transactions since its 2018 launch. SoLo aims to provide an equitable and empowering lending alternative, and is expanding its services to include banking, credit building, and premium member offerings.

7SIGNAL

Series B in 2017
7SIGNAL is an enterprise wireless experience monitoring company that offers a cloud-based platform designed to continuously assess wireless networks and identify performance issues affecting application functionality. By employing an "outside-in" monitoring approach, the platform provides visibility at the edge of both enterprise and home Wi-Fi networks, where user experience is critical. This capability enhances employee productivity, operational efficiency, and network return on investment. Targeted towards innovative organizations, educational institutions, healthcare systems, and government entities, 7SIGNAL's system is utilized by Fortune 500 companies, hospitals, and large venues worldwide. It simplifies the management of business-critical wireless LANs, reduces total ownership costs, and facilitates quicker problem resolution, particularly in remote environments, without the need to add extra wireless access points.

Monarch Teaching Technologies

Venture Round in 2017
Monarch Teaching Technologies, Inc. specializes in developing technology-enhanced solutions aimed at supporting educators, clinicians, and parents in the engagement and education of individuals with autism and other communication disorders. The company's flagship product, VizZle, is a web-based educational software that allows educators to create visually-supported curricula tailored to the needs of visual learners. This tool includes access to a peer-reviewed shared library of pre-made lessons as well as the ability to customize lessons using flexible templates, images, audio, and video clips. Additionally, Monarch Teaching Technologies provides training and help desk support to ensure effective use of its resources. Founded in 2005 and based in Shaker Heights, Ohio, the company was previously known as Ladybug, Inc.

Talmetrix

Venture Round in 2017
Talmetrix specializes in enhancing workplace well-being through employee feedback and analytics tools. The company's platform captures a diverse array of employee data, analyzes it to identify trends and concerns, and transforms this information into actionable insights. By focusing on the factors that influence employee experience and organizational performance, Talmetrix helps organizations improve decision-making and outcomes. Its technology and services empower businesses to foster a more positive work environment, ultimately enhancing employee satisfaction, engagement, and retention.

StreamLink Software

Venture Round in 2016
StreamLink Software-is a Software-as-a-Service company that develops grant management software for nonprofits and the public sector. Ther grants management solution, AmpliFund, is designed for managing every stage of the grant lifecycle and is at the forefront of automating grant compliance and data standardization in the public sector. It was founded in 2008 and is headquartered in Cleveland, Ohio.

ExpenseBot

Seed Round in 2016
ExpenseBot Inc. is a developer of an expense management platform that simplifies the process of business expense reporting. Founded in 2013 and headquartered in Shaker Heights, Ohio, the company offers a dashboard that allows users to create, approve, and reimburse expense reports efficiently. The platform leverages artificial intelligence, predictive analytics, and machine learning to automate the expense reporting process, pulling data from various sources such as calendar apps, emails, credit card transactions, and GPS. By analyzing expense data, ExpenseBot identifies reimbursable items and automatically generates expense reports when certain thresholds are met. This integration helps clients save time and reduces the challenges associated with organizing and submitting expenses.

Milo Biotechnology

Venture Round in 2016
Milo Biotechnology LLC, founded in 2011 and based in Cleveland Heights, Ohio, develops innovative therapies aimed at increasing muscle strength and preventing muscle atrophy in patients with neuromuscular diseases. The company's primary focus is its early clinical stage program involving AAV1-FS344, an adeno-associated virus that delivers the follistatin protein transgene. This product is designed to effectively promote muscle growth and enhance strength, specifically targeting multiple muscular dystrophies. Milo Biotechnology's research is exclusively licensed from Nationwide Children's Hospital, which underscores its commitment to advancing treatment options for individuals affected by these challenging conditions.

Unific

Seed Round in 2016
Unific is a company that specializes in e-commerce integration software aimed at enhancing marketing operations for small online retailers. Its platform enables businesses to automate marketing workflows, synchronize order details, and update customer information. By interpreting data effectively, Unific provides valuable analytics that assist companies in marketing their products, engaging with customers, and driving sales growth. The system is designed to help retailers convert website visitors into customers and foster long-term customer relationships.

StreamLink Software

Venture Round in 2016
StreamLink Software-is a Software-as-a-Service company that develops grant management software for nonprofits and the public sector. Ther grants management solution, AmpliFund, is designed for managing every stage of the grant lifecycle and is at the forefront of automating grant compliance and data standardization in the public sector. It was founded in 2008 and is headquartered in Cleveland, Ohio.

Checkpoint Surgical

Series C in 2015
Checkpoint Surgical Inc., established in 2009 and headquartered in Cleveland, Ohio, specializes in manufacturing neuro devices for surgeons. Their primary products are CHECKPOINT 9094 and CHECKPOINT 9394, both designed to locate, identify, and evaluate motor nerve tissue and muscle function during complex surgical procedures. These devices cater to various applications such as head and neck surgeries, hand and extremities procedures, targeted muscle re-innervation, orthopedic oncology and trauma, and plastic reconstruction. The company sells its products through a network of distributors in the United States, aiming to enhance patient outcomes by providing surgeons with precise nerve stimulation and monitoring equipment.

7SIGNAL

Series A in 2015
7SIGNAL is an enterprise wireless experience monitoring company that offers a cloud-based platform designed to continuously assess wireless networks and identify performance issues affecting application functionality. By employing an "outside-in" monitoring approach, the platform provides visibility at the edge of both enterprise and home Wi-Fi networks, where user experience is critical. This capability enhances employee productivity, operational efficiency, and network return on investment. Targeted towards innovative organizations, educational institutions, healthcare systems, and government entities, 7SIGNAL's system is utilized by Fortune 500 companies, hospitals, and large venues worldwide. It simplifies the management of business-critical wireless LANs, reduces total ownership costs, and facilitates quicker problem resolution, particularly in remote environments, without the need to add extra wireless access points.

O2 RegenTech

Pre Seed Round in 2015
O2 RegenTech specializes in developing and commercializing innovative wound care solutions. Their flagship product, OXAID™, utilizes proprietary, patented biopolymer technology to create an oxygenating, moist, and antimicrobial dressing. This dressing is designed to promote and accelerate the healing of chronic wounds, offering a cost-effective and user-friendly solution for patients. The company's focus is on providing advanced wound care that prevents and cures infections, improving overall patient outcomes.

Let's Gift It

Seed Round in 2013
Lets Gift It is an easy, fun and affordable way for friends, family, and coworkers to contribute towards the purchase of a gift for someone special. If you have ever organized or contributed towards a group gift, you know that collecting money, feeling obligated to give, and dealing with long email threads can be a pain. We experienced this pain and set out to build a better way to give as a group. Gift giving is about making someone's day special. Gift giving is not about how much you are able to spend. These two principals helped shape the product vision for Lets Gift It. We focused our efforts on creating a product that was easy to use, while making it affordable and fun for a folks who all have a connection to the recipient to give as a group. Lets Gift It is built on cutting edge technology to bring together people from a social graph, who for many different reasons, may not have otherwise been compelled to give a gift to a friend. Imagine its your birthday, and you opened the mail to find a new Callaway Driver generously gifted by the contributions of folks who may not know each other, but all know you. The collective buying power of the group can accomplish a lot of gifting.

BoxCast

Seed Round in 2013
BoxCast is a comprehensive video streaming solution that enables users to broadcast live events using a video camera. Its platform supports streaming through various channels, including websites, email, and social media, allowing viewers to access content on any internet-connected device, whether a computer, tablet, or smartphone. BoxCast offers features such as scalable video resolutions, easy-to-manage archives, privacy options, and data integration capabilities. Users can schedule broadcasts in advance, ensuring a seamless and jitter-free streaming experience for their audiences. This versatility makes BoxCast an effective tool for organizations looking to expand their reach through live video content.

Zuga

Seed Round in 2013
Zuga Medical Inc. is a company that specializes in the design, manufacture, and marketing of dental implant systems. Founded in 2009 and headquartered in Beachwood, Ohio, with a satellite office in Beijing, China, Zuga Medical offers a range of products including bone level dental implants, abutments, implant toolkits, and bone grafts. The company's innovative, patent-pending system simplifies the dental implant process, allowing dental professionals to reduce chair time and perform comprehensive services without relying on outsourced patient and laboratory services. Zuga Medical sells its products directly and online in the United States, as well as through distributor partners in China, and also provides training services to enhance the capabilities of dental professionals.

Movable

Seed Round in 2013
Movable is a company that specializes in developing wrist-worn activity monitors aimed at promoting health and wellness. Its flagship product, MOVband, tracks a user's daily activity by measuring all types of movement, not limited to steps. In addition to the MOVband, Movable provides MOVchallenge, a social-activity program that encourages participation through rewards and information sharing. The company's primary focus is on corporate and school-based wellness programs, aiming to engage users in their physical activities and improve overall health outcomes.

eFuneral

Seed Round in 2013
eFuneral is a digital sales and lead generation platform that specializes in online funeral planning services. Launched in 2019, the platform enables families to shop, select, and purchase funeral goods and services from the comfort of their homes, or with assistance from funeral staff. eFuneral has facilitated approximately $32 million in funeral arrangements for its partners, with $20 million attributed to preneed arrangements, as of December 2023. The company has assisted nearly 200,000 families by providing online quotes, helping them to understand the costs associated with personalized funeral arrangements. As a subsidiary of Homesteaders Life Company, eFuneral leverages its affiliation with one of the leading preneed insurance providers in the United States to enhance its offerings and support consumers in making informed decisions about end-of-life plans.

Intellirod Spine

Seed Round in 2013
Intellirod Spine, Inc. is a biomedical company based in Akron, Ohio, focused on the development and commercialization of innovative solutions for spinal surgery. The company's flagship product, the IntelliRod system, is a wireless implantable microelectronic sensor that attaches to spinal fusion implants. This sensor measures the load on the rod, providing surgeons with real-time data to assess the progress of spinal fusion over time. By offering objective insights into rod strain, the IntelliRod system helps spine surgeons evaluate the success of procedures, potentially reducing the need for unnecessary post-operative CT scans and exploratory surgeries. This technology not only aims to improve surgical outcomes but also facilitates quicker patient recovery and return to work after surgery. Intellirod Spine was previously known as OrthoData and was incorporated in 2003.

Casentric

Convertible Note in 2013
Casentric, LLC is a software company based in Shaker Heights, Ohio, founded in 2009. It specializes in developing CaseXpert, a cloud-based claims software designed for the property and casualty insurance sector. CaseXpert facilitates the evaluation and resolution of third-party personal injury and property damage claims, enabling claims handlers to assess liability and damages more accurately and efficiently. The application comprises four key components that streamline the claims process, including tools for evaluating comparative fault, assessing damages, generating reports, and providing negotiation guidance. By offering an intuitive interface, CaseXpert enhances the expertise of claims adjusters, reduces variability in claim outcomes, and helps organizations control expenses associated with claims. The software stands out in a market where many companies still rely on manual processes, contributing to inefficiencies and rising costs. Casentric's innovative approach addresses the industry's challenges, such as a shortage of experienced claims handlers and the need for improved training and evaluation methods, thereby positioning itself as a valuable solution for insurance companies looking to optimize their claims handling processes.

Guided Interventions

Seed Round in 2013
Guided Interventions is a Cleveland-based medical device startup led by CEO Dr. Matthew Pollman. The company specializes in the development of innovative wire-based medical devices, particularly a fractional flow reserve (FFR) guidewire aimed at enhancing coronary catheterization procedures. This guidewire is engineered to improve maneuverability and handling, allowing healthcare professionals to obtain accurate FFR measurements effectively. By focusing on maximizing efficacy while minimizing risks and costs, Guided Interventions seeks to reduce the reliance on stents for opening blocked arteries and to alleviate the painful and potentially dangerous side effects associated with heart surgery. Ultimately, the company aims to empower doctors to better assess the physiological impact of coronary artery blockages, thereby improving patient outcomes.

SoftoSource

Seed Round in 2012
SoftoSource is a software development company that specializes in a range of services, including the development of cloud and web applications, software testing, and database development. The company also focuses on business and requirements analysis, as well as user interface (UI) and user experience (UX) design. In addition to these services, SoftoSource has developed a learning content management system that provides comprehensive e-learning solutions. This system includes features such as an e-learning management platform, live web conferencing, and virtual classroom training, designed to enhance the educational experience for institutions by improving teacher productivity, efficiency, and student engagement.

MedCity News

Seed Round in 2012
MedCity News creates content for people who care about health care. It is a solution for media companies and organizations that need content, stakeholders who need actionable information about the medical industry, and advertisers who want to speak to this valuable niche audience. Founded by veteran journalists with both health care reporting and online editorial experience, MedCity News is poised to build an innovative new-media enterprise capable of taking advantage of these converging forces while building a profitable national business and brand. It operates the MedCity News Service, a type of niche wire service focused on the innovation economies in major "medical cities" and states (it has offices in Minnesota and Ohio, but also covers dealflow in the Midwest and Pittsburgh). It also operates MedCityNews.com and a custom content service that creates made-to-order content for anyone that wants it. Its news content is syndicated throughthe Ohio News Network, Akron Beacon Journal, The Kindle, WKYC, the Boston online journal MassDevice and the Zemanta blog aggregator, among others.

LifeMedix

Seed Round in 2012
LifeMedix, LLC specializes in the development of innovative medical resuscitation devices aimed at enhancing mobile healthcare services. The company's flagship product is a hand-held, ultra-portable infusion pump that operates independently by generating its own electricity through a piezoelectric component and built-in battery, eliminating the need for external power sources or battery recharging. This device is designed for prompt intravenous fluid resuscitation, enabling paramedics to provide faster pre-hospital care and facilitating home infusion treatments. Additionally, LifeMedix offers a cloud-based mobile software that helps identify potential medical issues through measurable metrics, further supporting healthcare providers in their critical decision-making processes.

Enforcer eCoaching

Seed Round in 2012
Enforcer eCoaching, Inc. is an email-based health coaching company based in Lyndhurst, Ohio, that specializes in delivering personalized wellness programs aimed at improving health outcomes, particularly for weight loss and diabetes management. Established in 2010, the company provides interactive and tailored health coaching services that focus on fostering enduring behavioral changes and enhancing the quality of life for its participants. By offering daily personalized advice and guidance, Enforcer eCoaching enables clients to adopt effective health-improvement strategies, including tobacco cessation and weight management, through a structured approach to wellness. The company collaborates with health systems and healthcare plans to reach a broader audience in its mission to promote healthier lifestyles.

Neuros Medical

Series B in 2012
Neuros Medical, Inc. is a neuromodulation company dedicated to developing innovative therapies to address unmet medical needs for patients globally. Founded in 2008 and headquartered in Willoughby Hills, Ohio, the company specializes in its proprietary platform technology known as Electrical Nerve Block. This technology is designed to eliminate chronic pain across various conditions, including neuroma/residual limb pain, chronic post-surgical pain, and chronic migraine. The Neuros Altius System, one of its key products, includes an implantable generator with an integrated rechargeable battery, a cuff electrode, and external devices, further demonstrating the company's commitment to advancing pain management solutions.

GenomOncology

Seed Round in 2012
GenomOncology, LLC is a Cleveland-based genomics technology and services company dedicated to advancing precision medicine. Established in 2012, the company specializes in translating next-generation sequencing (NGS) data into actionable insights for clinicians and researchers. Its flagship product, the GO Clinical Workbench, provides a decision support system that processes raw sequencing data to generate clinical reports based on the molecular profiles of individual tumor genomes. Additionally, GenomOncology offers GenomAnalytics, a platform designed for rapid genome analysis and discovery, and igniteIQ, which extracts clinically relevant data from various report formats to convert it into discrete data elements. The company also supports assay validation, integration with laboratory information systems and electronic medical records, and custom feature development, addressing a comprehensive range of needs within healthcare institutions to enhance cancer care and patient outcomes.

Cryothermic Systems

Seed Round in 2012
Cryothermic Systems, previously known as Life Core Technologies, is an American medical device company focused on developing innovative products to enhance patient outcomes by preventing brain damage. The company’s flagship product, Excel Cryo, is designed to lower brain temperature immediately following neurological injuries. This device operates without the need for electrical power, refrigeration, or external equipment, making it suitable for use in emergency medical services or intensive care units. The Excel Cryo is integrated into a cooling collar that holds a cooling pack in place, effectively extracting heat from the neck's blood vessels. This technology aims to assist healthcare providers in managing patients suffering from ischemic and reperfusion injuries related to conditions such as cardiac arrest, heart attack, stroke, and traumatic brain injury, thereby improving overall patient care and recovery outcomes.

Intelligent Mobile Support

Series A in 2012
Intelligent Mobile Support, Inc. is a technology company based in Solon, Ohio, founded in 2009. It specializes in developing a mobile cloud-computing platform aimed at enhancing the productivity and profitability of field sales and service teams, particularly within the HVAC industry. The company's product suite includes Sales Builder Pro, which automates the point-of-sale experience for clients, and Axon, an app that provides mobile access to essential parts information and technical support. Additionally, HVAC Proposal Builder Pro allows users to create professional proposals that facilitate immediate customer commitments. Intelligent Mobile Support serves a range of partners in the HVAC sector, including original equipment manufacturers, distributors, contractors, as well as providers in other home services such as plumbing and electrical work. The company's innovative solutions are designed to support sales representatives and technicians in the field, ultimately improving sales efficiency and closing rates.

Milo Biotechnology

Pre Seed Round in 2012
Milo Biotechnology LLC, founded in 2011 and based in Cleveland Heights, Ohio, develops innovative therapies aimed at increasing muscle strength and preventing muscle atrophy in patients with neuromuscular diseases. The company's primary focus is its early clinical stage program involving AAV1-FS344, an adeno-associated virus that delivers the follistatin protein transgene. This product is designed to effectively promote muscle growth and enhance strength, specifically targeting multiple muscular dystrophies. Milo Biotechnology's research is exclusively licensed from Nationwide Children's Hospital, which underscores its commitment to advancing treatment options for individuals affected by these challenging conditions.

Intelligent Mobile Support

Seed Round in 2011
Intelligent Mobile Support, Inc. is a technology company based in Solon, Ohio, founded in 2009. It specializes in developing a mobile cloud-computing platform aimed at enhancing the productivity and profitability of field sales and service teams, particularly within the HVAC industry. The company's product suite includes Sales Builder Pro, which automates the point-of-sale experience for clients, and Axon, an app that provides mobile access to essential parts information and technical support. Additionally, HVAC Proposal Builder Pro allows users to create professional proposals that facilitate immediate customer commitments. Intelligent Mobile Support serves a range of partners in the HVAC sector, including original equipment manufacturers, distributors, contractors, as well as providers in other home services such as plumbing and electrical work. The company's innovative solutions are designed to support sales representatives and technicians in the field, ultimately improving sales efficiency and closing rates.

SpearFysh

Pre Seed Round in 2011
SpearFysh, Inc., based in Twinsburg, Ohio, develops sales force automation tools designed to enhance business effectiveness and efficiency. The company's flagship product, SpearFysh, is a web-based application that enables executives, sales managers, and salespeople to manage, share, coach, and search conversations that have been machine analyzed. SpearFysh also offers a tablet device that captures field sales interactions in real-time, allowing organizations to share, search, and analyze customer and prospect interactions. Founded by Marc Miller, the company leverages proprietary software to translate captured sales interactions into valuable business intelligence, aiming to increase sales, accelerate selling cycles, and improve win rates. SpearFysh's technology supports various industries, including sales, consulting, healthcare, financial services, training, human resources, and hospitality.

Anderson Aerospace

Seed Round in 2011
Anderson Aerospace is a Kent, Ohio-based company specializing in the design and manufacture of advanced satellite antenna systems for the aviation industry. Founded to explore new opportunities in aerospace, advanced manufacturing, and satellite communications, the company boasts a team with over 140 years of collective experience, including 82 years specifically in the design, manufacture, and sale of aircraft satellite antenna systems. Their products are engineered to comply with the latest ARINC antenna specifications for large fuselage-mounted designs, allowing clients to achieve reductions in weight and power consumption while minimizing operational and installation costs.

Cureo

Pre Seed Round in 2011
Cureo is a web-based collaboration platform specifically designed for nonprofit organizations and community groups. The platform facilitates seamless communication and collaboration among internal team members, as well as external stakeholders such as board members, committee members, donors, volunteers, and community partners. Recognizing the complexities of collaboration in the nonprofit sector, Cureo enables users to interact without the need to log into cumbersome portal software, allowing for integration with multiple communication channels, including email. The platform features tools for team chat, event and task management, and content sharing, all while ensuring security and ease of use. Mobile-friendly and accessible from anywhere, Cureo is utilized by prominent global nonprofit entities to enhance organizational efficiency and foster collaborative success.

Cervilenz

Venture Round in 2011
CerviLenz is a new, disposable device that measure vaginal cervical length during a speculum exam. Cervical length is a powerful predictor of preterm birth risk and influences patient management decisions. CerviLenz gives clinicians an immediate, reliable method for measuring the cervix at the point of care. CerviLenz is manufactured and distributed by Cervilenz Inc. headquartered in Chagrin Falls, Ohio.

SironRX Therapeutics

Series A in 2011
SironRX is developing novel therapies exclusively licensed from Juventas Therapeutics and Cleveland Clinic that promote dermal wound repair and reduce scarring. Our lead product is a clinically tested biopharmaceutical that encodes Stromal cell-Derived Factor-1 (SDF-1). SDF-1 is key molecule responsible for activating natural repair processes after tissue injury through prevention of cell death and recruitment of stem cells to the damaged organ. Studies from several laboratories suggest the therapeutic potential of SDF-1 for treatment of a range of wounds such as post-surgical incisions, chronic diabetic ulcers and burns. Development of a cost-effective interactive wound therapy that can be topically administered at the site-of-injury or in chronic wound care settings with the potential to significantly improve function of the damaged tissue will have a major impact on the multi-billion dollar advanced wound management market.

Segmint

Venture Round in 2011
Segmint, Inc. is a data-driven technology company based in Cuyahoga Falls, Ohio, that specializes in providing customer insights through advanced data tagging, categorization, and contextualization. Founded in 2007, Segmint empowers financial institutions and fintech providers to effectively leverage customer data, enabling them to enhance customer interactions and measure marketing outcomes. The company's product suite includes Merchant Payment Cleansing, Transaction Analytics, and a Data-Driven Marketing Platform, along with solutions for competitor analysis, customer onboarding, and personalized marketing. Segmint's platform delivers targeted messages across various channels while adhering to privacy and security standards. With insights derived from billions of transactions, the company serves a diverse range of industries, including banking, retail, media, and insurance, helping organizations inform their strategies in competitive analysis, risk management, and product innovation.

Securus Medical Group

Series A in 2011
Securus Medical Group engages in the development of clinical tools to improve the safety and efficacy of ablation therapy by providing real-time, non-contact, high-resolution tissue temperature monitoring, and mapping products. The company engages in developing real-time, noncontact, thermal mapping systems to determine intrabody tissue temperatures.

CoverMyMeds

Seed Round in 2011
CoverMyMeds, LLC is a company that specializes in electronic prior authorization solutions for healthcare providers. Founded in 2008 and headquartered in Highland Hills, Ohio, with an additional office in Columbus, the company offers a platform that enables electronic health records, payers, pharmacies, and life sciences to complete prior authorization requests efficiently. This process is crucial for insurance companies to approve or deny prescriptions based on formulary status. CoverMyMeds provides a suite of integrated workflow tools designed to simplify the completion of prior authorization and insurance coverage determination forms for physicians and pharmacists at no cost. The company partners with pharmaceutical manufacturers to enhance patient access to branded medications, thereby streamlining the medication approval process and ensuring that patients receive the necessary treatments promptly. In 2017, CoverMyMeds became a subsidiary of McKesson Corporation.

CardioInsight Technologies

Series B in 2011
CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology called Electrocardiographic Mapping (ECM), which generates three-dimensional images of the heart's electrical activity by integrating body surface electrical data with anatomical data obtained from CT scans. The CardioInsight system employs a single-use disposable multi-sensor vest to capture electrical signals from the body surface, enabling the creation of detailed epicardial 3D electroanatomic maps and virtual electrograms. This innovative approach allows physicians to visualize real-time cardiac electrical activity and enhances the accuracy of diagnosing and treating conditions such as arrhythmias and congestive heart failure. CardioInsight's technology has been validated through over 260 patient studies, demonstrating its effectiveness in guiding therapeutic interventions. Founded in 2006, the company operates as a subsidiary of Medtronic plc.

Caralon Global

Seed Round in 2011
Caralon Global is developing and commercializing an ultra-thin, highly efficient insulation product. The patent-pending technology used to create its Nanotheca® insulation is a uniquely-manufactured vacuum insulated panel that reduces heat transfer better than traditional fiberglass or polyurethane products.

SPR Therapeutics

Seed Round in 2011
SPR Therapeutics, LLC is a medical device company based in Cleveland, Ohio, specializing in the development and commercialization of interventional pain management therapies. The company focuses on peripheral nerve stimulation (PNS) systems, with its flagship product being the Smartpatch, a minimally invasive device designed to deliver short-term therapy for pain relief. This system is effective for various types of pain, including post-surgical discomfort following procedures like knee replacements and thoracotomies, as well as neuropathic and musculoskeletal pain. In addition to the Smartpatch, SPR Therapeutics offers the Micropulse, an implantable PNS system for long-term therapy, and the Smartpatch MicroLead, which promotes rapid tissue ingrowth. By providing non-narcotic alternatives for pain management, SPR Therapeutics aims to offer safe and effective treatments that reduce reliance on opioid medications and invasive surgeries. The company was founded in 2009 and has additional facilities in the Carolina’s Research Triangle and Minneapolis, Minnesota.

Thermalin

Series A in 2011
Thermalin, Inc. is a biotechnology company based in Cleveland, Ohio, founded in 2010, that focuses on developing innovative insulin therapies for individuals with Type 1 and Type 2 diabetes. The company aims to transform the insulin and insulin delivery market, valued at $30 billion, through its cutting-edge, highly concentrated, ultra-rapid acting insulin and a novel glucose management system that is the size of a postage stamp. This insulin can also be utilized in existing insulin pumps, enhancing their efficiency. In addition to its lead program, Thermalin is exploring partnerships to create no-cold-chain basal and mix insulins, as well as glucose-responsive insulins. Its products are designed to be rapidly absorbing and do not require refrigeration, thereby reducing the burden of insulin therapy and improving patient adherence and health outcomes.

OrthoHelix Surgical Designs

Series D in 2011
OrthoHelix Surgical Designs is a specialized medical device company focused on developing innovative implants and instruments for small bone reconstructive surgeries, particularly in the areas of foot, ankle, hand, and wrist. The company is committed to enhancing surgical outcomes by providing state-of-the-art extremity fixation products that prioritize reliability and ease of use. Among its offerings is the DRLock Volar Plate and Screw System, designed for the repair of distal radius fractures and osteotomies. OrthoHelix emphasizes a responsive approach to product development, actively listening to surgeons to ensure that their needs are met, resulting in safer, faster, and more efficient surgical procedures. The company prides itself on its core values of integrity, compliance, dedication, focus, and speed.

SironRX Therapeutics

Venture Round in 2011
SironRX is developing novel therapies exclusively licensed from Juventas Therapeutics and Cleveland Clinic that promote dermal wound repair and reduce scarring. Our lead product is a clinically tested biopharmaceutical that encodes Stromal cell-Derived Factor-1 (SDF-1). SDF-1 is key molecule responsible for activating natural repair processes after tissue injury through prevention of cell death and recruitment of stem cells to the damaged organ. Studies from several laboratories suggest the therapeutic potential of SDF-1 for treatment of a range of wounds such as post-surgical incisions, chronic diabetic ulcers and burns. Development of a cost-effective interactive wound therapy that can be topically administered at the site-of-injury or in chronic wound care settings with the potential to significantly improve function of the damaged tissue will have a major impact on the multi-billion dollar advanced wound management market.

MedCity News

Seed Round in 2010
MedCity News creates content for people who care about health care. It is a solution for media companies and organizations that need content, stakeholders who need actionable information about the medical industry, and advertisers who want to speak to this valuable niche audience. Founded by veteran journalists with both health care reporting and online editorial experience, MedCity News is poised to build an innovative new-media enterprise capable of taking advantage of these converging forces while building a profitable national business and brand. It operates the MedCity News Service, a type of niche wire service focused on the innovation economies in major "medical cities" and states (it has offices in Minnesota and Ohio, but also covers dealflow in the Midwest and Pittsburgh). It also operates MedCityNews.com and a custom content service that creates made-to-order content for anyone that wants it. Its news content is syndicated throughthe Ohio News Network, Akron Beacon Journal, The Kindle, WKYC, the Boston online journal MassDevice and the Zemanta blog aggregator, among others.

Tursiop Technologies

Seed Round in 2010
Tursiop Technologies is developing revolutionary MRI coil devices utilizing proprietary nanotechnology, which will produce higher image quality and faster scan times resulting in a significant boost of the functional capabilities of any installed MRI system. Tursiop-generated imaging enhancements will apply across the entire range of MRI system field strengths, from low-field to high-field systems. Increased diagnostic competency will lead to improved patient outcomes and open the doors to new therapeutic opportunities within the areas of interventional, intra-operative and functional MRI and molecular imaging.

OnShift

Series A in 2010
OnShift is a provider of cloud-based human capital management software specifically designed to address workforce challenges in post-acute and long-term care facilities. The company's platform includes a comprehensive suite of tools for hiring, scheduling, employee engagement, and talent acquisition, aimed at enhancing productivity and profitability for healthcare organizations. With features such as predictive analytics and intuitive design, OnShift empowers clients to maintain a consistent and engaged workforce, ultimately driving quality care and reducing operational costs. Thousands of senior living and post-acute care organizations rely on OnShift's solutions to effectively manage their staffing needs and improve overall performance.

Ayalogic

Venture Round in 2010
Ayalogic, founded in 2002, specializes in providing integrated voice services primarily for indie game developers. The company has developed imVOX, a platform aimed at enhancing communication within the gaming industry. Since 2008, Ayalogic has been dedicated to supporting game developers with innovative solutions that facilitate better interaction among players. Additionally, Ayalogic operates the Green-Ear network, further expanding its reach and services in the gaming sector. The company is supported by several investment firms, including Draper Triangle Ventures, Early Stage Partners, and JumpStart, Inc.

CoverMyMeds

Seed Round in 2010
CoverMyMeds, LLC is a company that specializes in electronic prior authorization solutions for healthcare providers. Founded in 2008 and headquartered in Highland Hills, Ohio, with an additional office in Columbus, the company offers a platform that enables electronic health records, payers, pharmacies, and life sciences to complete prior authorization requests efficiently. This process is crucial for insurance companies to approve or deny prescriptions based on formulary status. CoverMyMeds provides a suite of integrated workflow tools designed to simplify the completion of prior authorization and insurance coverage determination forms for physicians and pharmacists at no cost. The company partners with pharmaceutical manufacturers to enhance patient access to branded medications, thereby streamlining the medication approval process and ensuring that patients receive the necessary treatments promptly. In 2017, CoverMyMeds became a subsidiary of McKesson Corporation.

Max Endoscopy

Seed Round in 2010
MAX Endoscopy designs and manufactures innovative endoscopic accessory devices that fill unmet needs in the field of Gastrointestinal (GI) endoscopy. We develop devices and instruments that are novel and yet practical and cost effective, providing opportunities for physicians in gastroenterology and related medical specialties to provide better treatment.

Thermalin

Venture Round in 2010
Thermalin, Inc. is a biotechnology company based in Cleveland, Ohio, founded in 2010, that focuses on developing innovative insulin therapies for individuals with Type 1 and Type 2 diabetes. The company aims to transform the insulin and insulin delivery market, valued at $30 billion, through its cutting-edge, highly concentrated, ultra-rapid acting insulin and a novel glucose management system that is the size of a postage stamp. This insulin can also be utilized in existing insulin pumps, enhancing their efficiency. In addition to its lead program, Thermalin is exploring partnerships to create no-cold-chain basal and mix insulins, as well as glucose-responsive insulins. Its products are designed to be rapidly absorbing and do not require refrigeration, thereby reducing the burden of insulin therapy and improving patient adherence and health outcomes.

Endotronix

Seed Round in 2010
Endotronix Inc. is a medical technology company based in Lisle, Illinois, founded in 2007. It specializes in the development of advanced hemodynamic monitoring solutions aimed at improving the management of heart failure. The company’s flagship product is a miniaturized, wireless implantable pressure sensor that is designed to be used during interventional cardiovascular procedures. This sensor interfaces with an external measurement device and is part of a broader platform that includes a cloud-based disease management system. Through its innovative technology, Endotronix enables healthcare professionals to detect worsening heart failure earlier, facilitating proactive patient management and enhancing clinical outcomes. The company's approach connects patients, clinicians, and reimbursement teams, providing a comprehensive solution for outpatient hemodynamic management.
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