Invest Michigan

Refraction AI, Inc., an autonomous delivery robot company, builds and deploys robotic platforms to provide goods delivery in urban areas. It offers The REV-1, a delivery robotic vehicle that picks up goods from restaurants, pharmacies, and grocery stores, and bring them directly to the customers’ house. Refraction AI, Inc. was founded in 2017 and is based in Ann Arbor, Michigan.

Shoulder Innovations, Inc. is a medical device company based in Holland, Michigan, specializing in orthopedic solutions for shoulder replacement surgery. Founded in 2009, the company has developed a Total Shoulder Replacement System that features innovative inset glenoid fixation technology, addressing the critical challenge of reliable fixation for glenoid implants. This technology not only enhances post-surgical implant stability, reducing the risk of revision surgeries, but also simplifies surgical instrumentation, which can lead to shorter operative times and lower costs. Shoulder Innovations markets its products through distribution partners across the United States, aiming to improve patient care and reduce overall healthcare costs.

Ripple Science Corporation, founded in 2016 and based in Ann Arbor, Michigan, specializes in developing web-based software aimed at improving the recruitment and management of participants in clinical, translational, and social science studies. The company's flagship product, Ripple SaaS, integrates sales and marketing automation tools specifically for participant recruitment, allowing research investigators to engage more participants efficiently. This software supports various functions, including study dashboard management, recruitment campaign oversight, and participant tracking—both potential and enrolled. Ripple Science's solutions cater to academic investigators, clinical trial sites, and contract research organizations, and the software is currently utilized by over 75 academic and research institutions globally, enhancing communication and collaboration throughout the clinical trial process.

Orbion Space Technology, Inc. specializes in the development and manufacturing of plasma propulsion systems designed for small satellites. Founded in 2016 and headquartered in Houghton, Michigan, the company provides electric propulsion technology that enables the last-mile delivery of spacecraft from launch vehicles to their designated orbits. This technology assists clients in maneuvering satellites in space, avoiding potential collisions, and ensuring safe de-orbiting at the conclusion of their mission lifetimes. Through its innovative propulsion systems, Orbion enhances the operational capabilities and longevity of small satellite missions.

ONL Therapeutics, Inc. is a biopharmaceutical company based in Ann Arbor, Michigan, focused on developing innovative therapies aimed at protecting vision by targeting photoreceptors. Established in 2006, the company specializes in creating photoreceptor protective agents that address the FAS apoptotic pathway, which is critical for preserving photoreceptor cells. With a growing market for retinal drugs exceeding $7 billion, ONL Therapeutics aims to overcome the limitations of existing treatments that do not target the initial neural component of vision loss. The company’s drug programs include small-molecule peptides designed to protect photoreceptors during vision-threatening conditions such as retinal detachment, ultimately enhancing patient outcomes and supporting successful surgical interventions.

GreenMark Biomedical Inc. is a minimally invasive healthcare company founded in 2016 and based in East Lansing, Michigan, with a laboratory in Ann Arbor. The company specializes in developing biopolymer nanoparticles derived from natural starch, which serves as an ideal carrier for various dental and medical applications due to its biodegradability by natural enzymes in the body. GreenMark's dental technologies focus on diagnosing and treating tooth decay through innovative tests and a mouth rinse product that illuminates cavities and early-stage lesions when exposed to standard dental curing lamps. In addition to its dental innovations, the company is also exploring applications for targeted anti-cancer drug delivery, aiming to improve treatment precision and patient comfort.

Fusion Coolant Systems, Inc. specializes in manufacturing and marketing advanced coolant and lubrication systems for the manufacturing industry, utilizing supercritical carbon dioxide technology. The company offers products such as Pure-Cut 1000 and LUBE-CUT 1600, which deliver supercritical CO2 with varying lubrication rates for different cutting applications. These systems enhance production rates and extend tool life while addressing the shortcomings of traditional metalworking fluids, which can pose health and environmental risks. Fusion Coolant's innovative CHiP Lube system significantly outperforms conventional methods, reducing costs and eliminating toxic waste. The company's products find applications in various sectors, including medical implants, aerospace, automotive, and power generation. Fusion Coolant Systems, founded in 2009 and based in Canton, Michigan, also maintains an office in Saint-Priest, France, and has a strategic partnership with Air Liquide.

Bloomscape, Inc. is an online retailer based in Detroit, Michigan, specializing in houseplants and plant care tools. Founded in 2017, the company offers a variety of potted plants, including species such as tradescantia zebriana, pinstripe, hedgehog aloe, and philodendron heartleaf, among others. Bloomscape simplifies the plant purchasing process by delivering ready-to-go plants directly to customers' doors. Additionally, the company provides a Plant Mom service, which allows customers to seek expert advice on plant care. By focusing on enhancing the overall experience of buying and caring for plants, Bloomscape aims to make home gardening accessible and enjoyable for its customers.

Fifth Eye Inc., a medical software company, develops a real time analytics system designed to analyze hemodynamic instability in patients. It offers early warning system that continuously forecasts patient trajectory, giving doctors and nurses a heads up about impending trouble hours in advance of other methods. The company's tool provides first score in five minutes with no baseline needed, minute-to-minute continuous patient assessment, advance warning and real-time treatment feedback, and historical trends without the need for electronic health record inputs. The company was formerly known as Trove Analytics, Inc. and changed its name to Fifth Eye Inc. in June 2018. Fifth Eye Inc. was incorporated in 2017 and is based in Ann Arbor, Michigan.

Mi Padrino is an online event planning service designed to assist families in organizing and funding celebrations rooted in Hispanic traditions, such as Quinceañeras, weddings, and baptisms. Founded by Kim Gamez, who has firsthand experience as a mother of five, the platform addresses the complexities involved in coordinating such significant events, enabling users to share event details with friends and family globally. Mi Padrino streamlines the planning process, making it easier for users to manage all aspects of their celebrations, regardless of the location of their loved ones. The service aims to simplify the organization of cherished cultural traditions, providing a unique solution tailored to the needs of the Hispanic community.

Ripple Science Corporation, founded in 2016 and based in Ann Arbor, Michigan, specializes in developing web-based software aimed at improving the recruitment and management of participants in clinical, translational, and social science studies. The company's flagship product, Ripple SaaS, integrates sales and marketing automation tools specifically for participant recruitment, allowing research investigators to engage more participants efficiently. This software supports various functions, including study dashboard management, recruitment campaign oversight, and participant tracking—both potential and enrolled. Ripple Science's solutions cater to academic investigators, clinical trial sites, and contract research organizations, and the software is currently utilized by over 75 academic and research institutions globally, enhancing communication and collaboration throughout the clinical trial process.

Ripple Science Corporation, founded in 2016 and based in Ann Arbor, Michigan, specializes in developing web-based software aimed at improving the recruitment and management of participants in clinical, translational, and social science studies. The company's flagship product, Ripple SaaS, integrates sales and marketing automation tools specifically for participant recruitment, allowing research investigators to engage more participants efficiently. This software supports various functions, including study dashboard management, recruitment campaign oversight, and participant tracking—both potential and enrolled. Ripple Science's solutions cater to academic investigators, clinical trial sites, and contract research organizations, and the software is currently utilized by over 75 academic and research institutions globally, enhancing communication and collaboration throughout the clinical trial process.