Longevity Vision Fund

Tessera Therapeutics is an early-stage life sciences company focused on pioneering Gene Writing technology, which allows for the permanent modification of the human genome. This innovative approach enables scientists and clinicians to introduce therapeutic messages into the genome, offering a potential cure for diseases at their source. By building on recent advancements in gene therapy and gene editing, Tessera Therapeutics aims to address significant limitations in these areas, enhancing their applicability and effectiveness. Founded by Flagship Pioneering, the company is positioned to transform genetic medicine and improve patient care through its groundbreaking technology.

Biolinq Inc. is a San Diego-based company that specializes in developing skin-applied electronic sensors designed to analyze body fluids for health monitoring. Founded in 2012 and originally known as Electrozyme LLC, Biolinq aims to enhance the experience of individuals with diabetes by providing a more affordable and pain-free alternative to conventional continuous glucose monitoring (CGM) systems. The company's platform features minimally invasive electrochemical biosensors capable of measuring multiple analytes, including glucose, ketones, and lactate. This innovative technology not only facilitates easier blood glucose monitoring but also delivers actionable insights into metabolic health, significantly improving the quality of life for patients managing diabetes.

Laronde is focused on developing innovative therapeutics using its proprietary Endless RNA™ (eRNA) platform, which allows for the modulation of human biology through uniquely engineered RNA. This technology enables the expression of diverse proteins within the body while being persistent, non-immunogenic, and suitable for repeat dosing. Additionally, it provides flexibility in formulation and delivery, making it a promising foundation for new medicines. Founded in 2017 by Flagship Labs, Laronde is rapidly scaling its operations to support the simultaneous development of various programs targeting multiple disease areas, aiming to create more predictable and impactful treatments in the healthcare sector.

Senda Biosciences is pioneering the field of Intersystems Biology to create novel treatments for human disease. Intersystems Biology focuses on how molecular connections between botanical, bacterial, and human cells—coevolved over millennia—define health and disease. Senda's Intersytems Biology discovery platform, built using new techniques in machine learning and computational biology, has been able to generate novel, actionable insights into the trillions of interspecies molecular connections in the human body, and harnesses the power of this "pharmacy within us" with novel pharmacological approaches. The power of the Senda platform is illustrated by six preclinical programs in oncology, neurology, chronic disease, and metabolic disease.

Tessera Therapeutics is an early-stage life sciences company focused on pioneering Gene Writing technology, which allows for the permanent modification of the human genome. This innovative approach enables scientists and clinicians to introduce therapeutic messages into the genome, offering a potential cure for diseases at their source. By building on recent advancements in gene therapy and gene editing, Tessera Therapeutics aims to address significant limitations in these areas, enhancing their applicability and effectiveness. Founded by Flagship Pioneering, the company is positioned to transform genetic medicine and improve patient care through its groundbreaking technology.

Valo Health is a new type of technology company, uniting human and machine intelligence aiming to accelerate the creation of life-changing treatments.

LyGenesis, Inc. is a biotechnology company based in Pittsburgh, Pennsylvania, focused on organ regeneration technology. Founded in 2017, the company develops a platform that utilizes a patient's lymph nodes as bioreactors to regrow ectopic organs. Its primary target is liver regeneration, specifically aimed at aiding patients with end-stage liver disease. The technology enables the transplantation of donor cells through outpatient endoscopic ultrasound, facilitating the growth of functioning organs within the patient's body. In addition to liver regeneration, LyGenesis is exploring therapeutic applications for other organs, including the thymus, pancreas, and kidney.

Eko harnesses the power of smartphones and cloud data for monitoring patients with cardiovascular diseases. It has built a platform of non-invasive cardiovascular monitoring devices, clinical software, and point-of-care decision support algorithms to improve the delivery of cardiovascular care. In 2015, Eko launched the Eko Core Digital Stethoscope, the first FDA-cleared digital stethoscope on the market to wirelessly stream heart and lung sound to HIPAA-compliant software. For the first time in history, patient sounds can be integrated with electronic health records (EHRs) for more seamless referrals, documentation, and monitoring. Eko was established in 2013 and is based in Berkeley, California.

Deep Longevity, Inc. is a biotechnology company focused on advancing the field of aging and longevity through the development of innovative biomarkers and predictive tools. Established in 2016 and headquartered in Hong Kong, the company creates aging clocks and biomarker platforms that utilize various data types, including clinical blood tests, transcriptomic, proteomic, and epigenetic data. Its offerings include Longevity Cloud, which hosts deep aging clocks, and Young.AI, an application designed for tracking biological age and providing recommendations for longevity interventions. Additionally, Deep Longevity produces AgeMetric Reports to help users monitor their biological age over time. By leveraging artificial intelligence, the company aims to enable longevity clinics and healthcare providers to more accurately assess and improve individual health outcomes related to aging.

4D Molecular Therapeutics is a clinical-stage gene therapy company based in Emeryville, California, that specializes in developing targeted gene therapy products using evolved adeno-associated virus vectors. The company has a diverse portfolio focusing on three main therapeutic areas: ophthalmology, cardiology, and pulmonology. Key product candidates include 4D-125, currently in a Phase I/II clinical trial for treating X-linked retinitis pigmentosa; 4D-110, in a Phase I trial for choroideremia; and 4D-310, also in a Phase I/II trial for Fabry disease. Additionally, 4D Molecular Therapeutics is developing investigational new drug candidates such as 4D-150 for wet age-related macular degeneration and 4D-710 for cystic fibrosis lung disease. The company aims to address unmet medical needs through its innovative gene therapies.

Sigilon Therapeutics, Inc., a biopharmaceutical company, develops functional cures for patients with chronic diseases. Its lead product candidate is SIG-001, which is in Phase I/II clinical trial to prevent bleeding episodes in patients with moderate-severe to severe Hemophilia A. The company is also developing SIG-005 to treat the non-neurological manifestations of the disease in patients with mucopolysaccharidosis type 1; and SIG-002 designed to replace islet cells for the treatment of type 1 diabetes. The company was formerly known as Sigilon, Inc. and changed its name to Sigilon Therapeutics, Inc. in June 2017. Sigilon Therapeutics, Inc. was founded in 2015 and is headquartered in Cambridge, Massachusetts.

LyGenesis, Inc. is a biotechnology company based in Pittsburgh, Pennsylvania, focused on organ regeneration technology. Founded in 2017, the company develops a platform that utilizes a patient's lymph nodes as bioreactors to regrow ectopic organs. Its primary target is liver regeneration, specifically aimed at aiding patients with end-stage liver disease. The technology enables the transplantation of donor cells through outpatient endoscopic ultrasound, facilitating the growth of functioning organs within the patient's body. In addition to liver regeneration, LyGenesis is exploring therapeutic applications for other organs, including the thymus, pancreas, and kidney.

InSilico Medicine, Inc. is an artificial intelligence company focused on drug discovery, biomarker development, and aging research. Founded in 2014 and headquartered in Baltimore, Maryland, the company employs advanced AI technologies, including deep learning and generative adversarial networks, to create novel molecular structures for diseases with known and unknown targets. Its comprehensive platform covers all stages of drug development, from discovery to clinical trials. Key initiatives include Pharma.AI, which offers machine learning services to various industries, and Young.AI, which predicts biological age. InSilico Medicine also engages in internal drug discovery programs targeting conditions such as cancer, Parkinson's Disease, and age-related disorders. Additionally, the company has partnered with Life Extension to develop nutraceutical products using its bioinformatics and deep learning techniques. Through its innovative solutions, InSilico Medicine aims to enhance personalized healthcare and mitigate the effects of aging.

InSilico Medicine, Inc. is an artificial intelligence company focused on drug discovery, biomarker development, and aging research. Founded in 2014 and headquartered in Baltimore, Maryland, the company employs advanced AI technologies, including deep learning and generative adversarial networks, to create novel molecular structures for diseases with known and unknown targets. Its comprehensive platform covers all stages of drug development, from discovery to clinical trials. Key initiatives include Pharma.AI, which offers machine learning services to various industries, and Young.AI, which predicts biological age. InSilico Medicine also engages in internal drug discovery programs targeting conditions such as cancer, Parkinson's Disease, and age-related disorders. Additionally, the company has partnered with Life Extension to develop nutraceutical products using its bioinformatics and deep learning techniques. Through its innovative solutions, InSilico Medicine aims to enhance personalized healthcare and mitigate the effects of aging.

Juvenescence Limited is a British Virgin Islands-based holding company focused on investing in human aging and longevity. The company has raised substantial capital to establish a comprehensive ecosystem aimed at addressing aging, age-related diseases, and regeneration. Juvenescence aims to leverage recent scientific advancements to develop therapeutics that can significantly extend human healthspan and lifespan. The company's approach involves creating and partnering with new ventures that specialize in longevity-related therapies, in-licensing promising compounds from academic and industry sources, and collaborating with leading scientists and research institutions. Their work is grounded in a modern understanding of the biological mechanisms of aging, allowing them to create evidence-based treatments for age-associated diseases. Ultimately, Juvenescence seeks to enhance both lifespan and healthspan by developing therapies that slow the aging process and promote rejuvenation.

Exo is a medical device startup handheld ultrasound platform and AI for imaging and therapeutic applications. The company is committed to delivering affordable and easy-to-use medical imaging to healthcare professionals around the world. By delivering easy-to-use, high-quality medical imaging. Exo empowers healthcare professionals to make critical, real-time decisions that improve patient outcomes. The Exo ultrasound platform combines advances in nano-materials, novel sensor technologies, advanced signal processing, and computation with the economies of scale of semiconductor manufacturing to dramatically reduce the cost of imaging. It also represents a giant leap in imaging and therapeutics technology one that will drive the development of high-performance products that are accessible, easy-to-use, and available at a price point never before possible.

Freenome, Inc., is an artificial intelligence (AI) genomics biotech company. The company develops and provides a medical arti?cial intelligence platform for early detection of cancer. It develops blood tests for early-cancer screening and treatment selection. The company also provides clinical research services. Freenome, Inc. was founded in 2014 and is based in South San Francisco, California.

Valo Health is a new type of technology company, uniting human and machine intelligence aiming to accelerate the creation of life-changing treatments.

Deciduous Therapeutics is an aging therapeutics company developing a novel class of immune-modulatory therapies that clear senescent cells and promote a healthy lifespan. Deciduous is led by Anil Bhushan, a professor at UCSF, and Robin Mansukhani, a five-time biotech founder.