Orthofix International

Neo Medical SA is a medical technology company based in Villette, Switzerland, with additional offices in Germany, France, and the United States. Founded in 2013, the company specializes in developing, manufacturing, and commercializing non-constraint thoraco-lumbar spinal fusion systems for spinal surgery. Its flagship product, the Neo Pedicle Screw System, offers a range of functionalities such as reduction, compression, distraction, and screw augmentation, addressing various pathologies including degenerative conditions, tumors, and trauma. Neo Medical aims to enhance the efficiency of healthcare delivery by providing versatile and high-quality surgical solutions, thereby contributing to the ongoing pursuit of healthcare cost optimization.

Bone Biologics Corporation is a medical device company based in Burlington, Massachusetts, specializing in bone regeneration technologies. The company's primary focus is on developing NELL-1, a recombinant human protein that plays a crucial role in bone development. This proprietary technology is integrated into the NELL-1/DBX Fusion Device, designed for spinal fusion procedures targeting skeletally mature patients suffering from degenerative disc disease, specifically at one level from L4-S1. Bone Biologics aims to enhance surgical outcomes across various specialties, including spinal surgery, orthopedics, neurosurgery, interventional radiology, and sports medicine. The company has established a license agreement with the UCLA Technology Development Group to further develop and commercialize NELL-1 for spinal fusion applications, reflecting its commitment to advancing innovative healthcare solutions since its founding in 2004.

Spinal Kinetics LLC is a medical device company based in Sunnyvale, California, that specializes in the design and development of non-fusion motion preservation systems aimed at treating degenerative diseases of the cervical and lumbar spine. Founded in 2003, the company offers the M6-C artificial cervical disc and the M6-L artificial lumbar disc, both of which replicate the anatomical and biomechanical properties of natural intervertebral discs. This innovative approach allows for the incorporation of an artificial nucleus and annulus, providing surgeons with a practical option for disc replacement. Spinal Kinetics distributes its products through a network of distributors across multiple countries, including Australia, Canada, several European nations, and the United Arab Emirates. The company operates as a subsidiary of Orthofix Medical Inc.

Innovative Spinal Technologies is a company focused on developing advanced solutions for spinal disorders, emphasizing motion preservation and minimally invasive treatments. Founded in 2002 and headquartered in Mansfield, Massachusetts, the company offers a range of products designed to enhance surgical outcomes. Key offerings include the AXIENT Dynamic Fixation system, a pedicle screw-based motion system, and the PARAMOUNT Lumbar Fusion System, which is adaptable for various surgical approaches, including minimally invasive and open procedures. Additionally, the PARAMOUNT MIS Pedicle Screw System caters to both single and multi-level spinal surgeries, while the PARAMOUNT Open Pedicle Screw System is tailored for minimally invasive lumbar fusion needs. The PARAMOUNT VBR system is specifically designed for minimally invasive transforaminal approaches, underscoring the company's commitment to innovative spinal care solutions.