Excel Venture Management

Excel Venture Management is a Boston-based venture capital firm established in 2007 that focuses on investing in early to late-stage companies primarily within the healthcare and life sciences sectors. The firm targets a diverse range of industries, including healthcare IT, diagnostics, medical devices, pharmaceuticals, and biotechnology, while also exploring opportunities in adjacent markets such as energy, chemicals, defense, and agriculture. Excel Venture Management aims to build companies that utilize transformative life science technologies to address significant challenges in healthcare and other fields. The firm has a notable investment track record, with many of its prior investments contributing to successful exits that have generated substantial value.

Frederick Blume

Managing Director

Rick Blume

Managing Director

Chris Seitz

Venture Fellow

Caleb Winder

Managing Director

65 past transactions

Ayogo

Series B in 2020
Ayogo Health Inc. is a Vancouver-based company that specializes in developing games and applications aimed at managing chronic health conditions and enhancing patient adherence. Founded in 2008, Ayogo utilizes behavioral psychology and social gaming principles to improve health outcomes. Its flagship product, GoodLife, offers a customizable platform featuring gamification elements, incentives, and social interactions to engage users effectively. Additionally, Ayogo's Alternate Reality Games provide a suite of learning applications that blend online and real-world experiences. The company collaborates closely with patients, end-users, and clients, which include insurers, healthcare providers, and pharmaceutical companies. By focusing on psychosocial factors, Ayogo's platform enhances patient activation, adherence, and persistence in treatment, ultimately aiming to foster healthier patients and better financial outcomes for healthcare organizations.

NeoSensory

Series A in 2019
Neosensory, Inc. is a company that specializes in developing wearable devices aimed at enhancing sensory perception for individuals. Founded in 2015 and based in San Mateo, California, Neosensory offers products such as Buzz, which utilizes vision-to-touch sensory substitution technology to assist blind individuals. The company focuses on transmitting various data streams to the brain through the sense of touch, leveraging the skin's potential for information delivery. Their innovative approach includes building hearing assistive technology that allows users to perceive sound through vibrations on the skin. Neosensory also provides a companion application for its products, enhancing the user experience and accessibility of information.

ClearDATA

Series E in 2018
ClearDATA Networks, Inc. specializes in healthcare cloud computing and information security solutions, catering to healthcare providers, life sciences organizations, and payers. Founded in 2009 and headquartered in Austin, Texas, with additional offices in San Francisco and Scottsdale, the company offers a multi-cloud platform that automates, protects, and manages healthcare applications and data. Key offerings include ClearDATA Comply, which helps organizations ensure cloud compliance with privacy regulations; ClearDATA Assess, designed for conducting mandatory HIPAA Security Risk Assessments; and ClearDATA Locate Mask, which enables healthcare organizations to utilize sensitive data safely by masking personal information. ClearDATA's HITRUST-certified cloud is recognized for its robust security and compliance solutions, providing a comprehensive Business Associate Agreement (BAA) and enabling clients to improve data management while minimizing privacy risks. The company's services extend to process design, solution architecture, custom development, and security risk assessments, empowering the healthcare sector to enhance service delivery through advanced analytics and scalable IT infrastructure.

Openwater

Seed Round in 2018
Openwater designs and develops MRI-resolution wearables that medical diagnoses and treatments, and a new era of fluid and affordable brain-to-computer communications to consumer electronics manufacturing facilities and techniques. The company was founded in 2016 and is based in San Francisco, California.

InfoBionic

Venture Round in 2018
InfoBionic, Inc. is a healthcare technology company based in Massachusetts, founded in 2011. It specializes in remote patient monitoring through its MoMe™ platform, which is a cloud-based service designed to enhance the efficiency of cardiac diagnostic services. The MoMe System focuses on cardiac arrhythmia detection, allowing healthcare providers to monitor patients' heart health continuously by streaming electrocardiogram, respiration, and motion data to the cloud for real-time analysis. This technology aims to improve clinical efficiency and patient care by providing physicians with anytime, anywhere access to critical patient data, ultimately facilitating better detection and treatment of cardiac complications.

Openwater

Seed Round in 2018
Openwater designs and develops MRI-resolution wearables that medical diagnoses and treatments, and a new era of fluid and affordable brain-to-computer communications to consumer electronics manufacturing facilities and techniques. The company was founded in 2016 and is based in San Francisco, California.

ClearDATA

Series D in 2017
ClearDATA Networks, Inc. specializes in healthcare cloud computing and information security solutions, catering to healthcare providers, life sciences organizations, and payers. Founded in 2009 and headquartered in Austin, Texas, with additional offices in San Francisco and Scottsdale, the company offers a multi-cloud platform that automates, protects, and manages healthcare applications and data. Key offerings include ClearDATA Comply, which helps organizations ensure cloud compliance with privacy regulations; ClearDATA Assess, designed for conducting mandatory HIPAA Security Risk Assessments; and ClearDATA Locate Mask, which enables healthcare organizations to utilize sensitive data safely by masking personal information. ClearDATA's HITRUST-certified cloud is recognized for its robust security and compliance solutions, providing a comprehensive Business Associate Agreement (BAA) and enabling clients to improve data management while minimizing privacy risks. The company's services extend to process design, solution architecture, custom development, and security risk assessments, empowering the healthcare sector to enhance service delivery through advanced analytics and scalable IT infrastructure.

Oculus Health

Series A in 2017
Oculus Health, Inc. operates a chronic care management platform that connects healthcare providers with patients and caregivers. Founded in 2014 and based in Irving, Texas, the company offers a range of services including access to personalized care plans, online and phone support from medical assistants, and real-time health data monitoring. Its platform integrates information from various healthcare sources, such as hospitals and laboratories, to facilitate seamless communication among care teams. Oculus Health also provides tools for remote monitoring, health record management, and patient engagement, aimed at improving patient outcomes and care adherence. By empowering individuals to manage their health proactively, the company seeks to enhance the overall experience of both patients and healthcare providers in a rapidly evolving healthcare landscape.

Qstream

Series B in 2016
Qstream, Inc. develops a software as a service based mobile sales acceleration software for managing and measuring the human side of sales acceleration. It serves companies in technology, financial services, and life sciences sectors. Qstream, Inc. was formerly known as Spaced Education, Inc. The company was incorporated in 2008 and is based in Burlington, Massachusetts with engineering facilities in Dublin, Ireland; and Hood River, Oregon. It has a sales headquarters in Maidenhead, United Kingdom and an office in San Francisco.

Zipongo

Series B in 2016
Zipongo is a company focused on promoting healthy eating habits among individuals through personalized food recommendations. Their platform is designed for employers and health plans, providing tools and content that facilitate healthy eating both at home and in the workplace. By offering actionable data and insights on dietary impacts on overall health, Zipongo aims to enhance the well-being of employees and members while contributing to significant reductions in health-related costs. Additionally, the company provides deals on healthy food, recipes, and nutrition tips, further supporting individuals in making better food choices.

InfoBionic

Series B in 2016
InfoBionic, Inc. is a healthcare technology company based in Massachusetts, founded in 2011. It specializes in remote patient monitoring through its MoMe™ platform, which is a cloud-based service designed to enhance the efficiency of cardiac diagnostic services. The MoMe System focuses on cardiac arrhythmia detection, allowing healthcare providers to monitor patients' heart health continuously by streaming electrocardiogram, respiration, and motion data to the cloud for real-time analysis. This technology aims to improve clinical efficiency and patient care by providing physicians with anytime, anywhere access to critical patient data, ultimately facilitating better detection and treatment of cardiac complications.

N-of-One

Series B in 2016
N-of-One, Inc. is a molecular decision support company that specializes in the interpretation of molecular test results for cancer care. It provides clinicians with detailed insights into the biological relevance of diseases, clinical evidence, associated therapies, and references. The company interprets next-generation sequencing (NGS) data from solid and hematological tumors, as well as circulating tumor cells and DNA. N-of-One delivers a clinical interpretation report called PrecisionInsights, which covers 15-20 gene NGS panels, summarizing clinical and scientific evidence for each biomarker relevant to specific cancer subtypes and listing potential therapeutic options. Additionally, it offers TRIALMATCH, a solution for matching patients to suitable clinical trials based on their individual profiles. N-of-One serves various stakeholders, including commercial and hospital laboratories and precision medicine programs. Founded in 2007 and based in Lexington, Massachusetts, N-of-One operates as a subsidiary of QIAGEN N.V. since January 2019.

WellDoc

Series B in 2015
WellDoc, Inc. is a digital health company focused on chronic disease management, particularly diabetes care. Founded in 2005 and headquartered in Baltimore, Maryland, WellDoc offers innovative solutions such as the DiabetesManager platform and BlueStar mobile prescription therapy. The DiabetesManager platform facilitates patient-provider coordination through features like personalized coaching, medication reminders, and real-time alerts, while BlueStar offers patients immediate guidance to enhance self-management of diabetes. WellDoc’s services also include clinical decision support for healthcare professionals and a comprehensive suite of technical services, such as software development and regulatory management. The company aims to improve health outcomes and reduce healthcare costs by integrating behavioral and motivational applications with everyday technology. WellDoc serves a diverse range of clients, including payors, employers, pharmaceutical and medical device companies, and healthcare providers.

ClearDATA

Series C in 2015
ClearDATA Networks, Inc. specializes in healthcare cloud computing and information security solutions, catering to healthcare providers, life sciences organizations, and payers. Founded in 2009 and headquartered in Austin, Texas, with additional offices in San Francisco and Scottsdale, the company offers a multi-cloud platform that automates, protects, and manages healthcare applications and data. Key offerings include ClearDATA Comply, which helps organizations ensure cloud compliance with privacy regulations; ClearDATA Assess, designed for conducting mandatory HIPAA Security Risk Assessments; and ClearDATA Locate Mask, which enables healthcare organizations to utilize sensitive data safely by masking personal information. ClearDATA's HITRUST-certified cloud is recognized for its robust security and compliance solutions, providing a comprehensive Business Associate Agreement (BAA) and enabling clients to improve data management while minimizing privacy risks. The company's services extend to process design, solution architecture, custom development, and security risk assessments, empowering the healthcare sector to enhance service delivery through advanced analytics and scalable IT infrastructure.

Ayogo

Series A in 2015
Ayogo Health Inc. is a Vancouver-based company that specializes in developing games and applications aimed at managing chronic health conditions and enhancing patient adherence. Founded in 2008, Ayogo utilizes behavioral psychology and social gaming principles to improve health outcomes. Its flagship product, GoodLife, offers a customizable platform featuring gamification elements, incentives, and social interactions to engage users effectively. Additionally, Ayogo's Alternate Reality Games provide a suite of learning applications that blend online and real-world experiences. The company collaborates closely with patients, end-users, and clients, which include insurers, healthcare providers, and pharmaceutical companies. By focusing on psychosocial factors, Ayogo's platform enhances patient activation, adherence, and persistence in treatment, ultimately aiming to foster healthier patients and better financial outcomes for healthcare organizations.

Gemphire Therapeutics

Seed Round in 2015
Gemphire Therapeutics Inc. is a clinical-stage biopharmaceutical company that focuses on developing and commercializing therapies for cardiometabolic disorders, particularly dyslipidemia and nonalcoholic fatty liver disease (NAFLD/NASH). The company is advancing gemcabene, an innovative oral medication aimed at lowering LDL cholesterol levels in patients who cannot achieve their lipid-lowering goals, including those on maximally tolerated statin therapy. Gemphire has completed three Phase IIb clinical trials for gemcabene, targeting conditions such as homozygous familial hypercholesterolemia (HoFH), hypercholesterolemia in heterozygous familial cases, and severe hypertriglyceridemia. Founded in 2008 and initially based in Livonia, Michigan, the company underwent a reverse merger with NeuroBo Pharmaceuticals in 2019, which has influenced its strategic direction and operations.

Orionis Biosciences

Seed Round in 2015
Orionis Biosciences operates in the healthcare industry focusing on the biotechnology business and innovation. The company is an early-stage drug discovery and development biotechnology company fueled by a suite of disruptive technologies to advance innovative medicines for the treatment of diseases with high unmet medical needs – with an initial internal focus in oncology and immunotherapies. Orionis Biosciences has research facilities in the Boston area (Headquarters in Waltham, MA, USA) and Ghent (Belgium), and is operated by a world class team of entrepreneurs, scientists and transatlantic network of investors, in concert with strategic research and development collaborations. The latter includes collaborations with VIB (Belgium), Orionis Biosciences co-founding institution.

Aventura Software

Series C in 2015
Aventura intelligently orchestrates assets, people, and systems to deliver the right information at the right time based on location and credentials. It locates and re-assigns the closest online printer and uniquely manages print routing to make it easier to detect and fix printing failures. Aventura was formed in 2007 and headquartered in Denver, Colorado.

Qstream

Series A in 2015
Qstream, Inc. develops a software as a service based mobile sales acceleration software for managing and measuring the human side of sales acceleration. It serves companies in technology, financial services, and life sciences sectors. Qstream, Inc. was formerly known as Spaced Education, Inc. The company was incorporated in 2008 and is based in Burlington, Massachusetts with engineering facilities in Dublin, Ireland; and Hood River, Oregon. It has a sales headquarters in Maidenhead, United Kingdom and an office in San Francisco.

Zipongo

Series A in 2014
Zipongo is a company focused on promoting healthy eating habits among individuals through personalized food recommendations. Their platform is designed for employers and health plans, providing tools and content that facilitate healthy eating both at home and in the workplace. By offering actionable data and insights on dietary impacts on overall health, Zipongo aims to enhance the well-being of employees and members while contributing to significant reductions in health-related costs. Additionally, the company provides deals on healthy food, recipes, and nutrition tips, further supporting individuals in making better food choices.

Aileron Therapeutics

Series E in 2014
Aileron Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing and commercializing a novel class of drugs known as stabilized cell-permeating alpha-helical peptides, particularly in the field of oncology. The company’s lead drug candidate, ALRN-6924, is currently undergoing multiple clinical trials, including Phase 2a studies for advanced solid tumors and peripheral T-cell lymphoma, as well as Phase 1 trials for acute myeloid leukemia and advanced myelodysplastic syndrome. Aileron is also working on a next-generation wild type p53 reactivator. Collaborations with notable institutions, such as Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Pfizer, further enhance its research efforts, particularly in evaluating ALRN-6924 in combination therapies. Aileron Therapeutics was founded in 2001, originally named Renegade Therapeutics, and is headquartered in Watertown, Massachusetts.

Molecular Templates

Venture Round in 2014
Molecular Templates, Inc. is a clinical-stage biopharmaceutical company based in Austin, Texas, dedicated to discovering and developing biologic therapeutics for cancer treatment. The company utilizes a proprietary platform known as engineered toxin bodies to create targeted therapies. Its lead candidate, MT-3724, is currently undergoing Phase II clinical trials for relapsed and refractory diffuse large B-cell lymphoma and non-Hodgkin’s lymphoma. In addition, the company is developing other candidates, including MT-4019, which targets CD38, and has collaborations with Takeda Pharmaceutical Company and Vertex Pharmaceuticals. These partnerships aim to enhance treatment options for conditions like multiple myeloma and improve outcomes in hematopoietic stem cell transplants. Molecular Templates continues to expand its pipeline with additional compounds targeting various cancers.

Aileron Therapeutics

Series E in 2013
Aileron Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing and commercializing a novel class of drugs known as stabilized cell-permeating alpha-helical peptides, particularly in the field of oncology. The company’s lead drug candidate, ALRN-6924, is currently undergoing multiple clinical trials, including Phase 2a studies for advanced solid tumors and peripheral T-cell lymphoma, as well as Phase 1 trials for acute myeloid leukemia and advanced myelodysplastic syndrome. Aileron is also working on a next-generation wild type p53 reactivator. Collaborations with notable institutions, such as Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Pfizer, further enhance its research efforts, particularly in evaluating ALRN-6924 in combination therapies. Aileron Therapeutics was founded in 2001, originally named Renegade Therapeutics, and is headquartered in Watertown, Massachusetts.

ShapeUp

Series B in 2013
ShapeUp is the leading provider of clinically-proven social networking-powered corporate wellness solutions. ShapeUp covers more than 2 million lives on its online platform and serves more than 500 employers and health plans in 109 countries. It was founded in 2006 and headquartered in Providence, Rhode Island.

Pathogenetix

Series C in 2013
PathoGenetiX is developing an automated system for the rapid identification of pathogenic bacterial strains using proprietary Genome Sequence Scanning Technology. The company's approach, which employs a single reagent set to generate genomic bar codes based on bacterial DNA, can cost-effectively identify thousands of strains in a single test from complex samples in three hours. PathoGenetiX is developing its GSS platform for use in genomics research, food and product safety testing, and clinical infectious disease diagnostics, with the initial commercial introduction into the research market planned for 2012.

Molecular Templates

Series C in 2013
Molecular Templates, Inc. is a clinical-stage biopharmaceutical company based in Austin, Texas, dedicated to discovering and developing biologic therapeutics for cancer treatment. The company utilizes a proprietary platform known as engineered toxin bodies to create targeted therapies. Its lead candidate, MT-3724, is currently undergoing Phase II clinical trials for relapsed and refractory diffuse large B-cell lymphoma and non-Hodgkin’s lymphoma. In addition, the company is developing other candidates, including MT-4019, which targets CD38, and has collaborations with Takeda Pharmaceutical Company and Vertex Pharmaceuticals. These partnerships aim to enhance treatment options for conditions like multiple myeloma and improve outcomes in hematopoietic stem cell transplants. Molecular Templates continues to expand its pipeline with additional compounds targeting various cancers.

Aventura Software

Series B in 2013
Aventura intelligently orchestrates assets, people, and systems to deliver the right information at the right time based on location and credentials. It locates and re-assigns the closest online printer and uniquely manages print routing to make it easier to detect and fix printing failures. Aventura was formed in 2007 and headquartered in Denver, Colorado.

ClearDATA

Series B in 2013
ClearDATA Networks, Inc. specializes in healthcare cloud computing and information security solutions, catering to healthcare providers, life sciences organizations, and payers. Founded in 2009 and headquartered in Austin, Texas, with additional offices in San Francisco and Scottsdale, the company offers a multi-cloud platform that automates, protects, and manages healthcare applications and data. Key offerings include ClearDATA Comply, which helps organizations ensure cloud compliance with privacy regulations; ClearDATA Assess, designed for conducting mandatory HIPAA Security Risk Assessments; and ClearDATA Locate Mask, which enables healthcare organizations to utilize sensitive data safely by masking personal information. ClearDATA's HITRUST-certified cloud is recognized for its robust security and compliance solutions, providing a comprehensive Business Associate Agreement (BAA) and enabling clients to improve data management while minimizing privacy risks. The company's services extend to process design, solution architecture, custom development, and security risk assessments, empowering the healthcare sector to enhance service delivery through advanced analytics and scalable IT infrastructure.

Aileron Therapeutics

Series D in 2013
Aileron Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing and commercializing a novel class of drugs known as stabilized cell-permeating alpha-helical peptides, particularly in the field of oncology. The company’s lead drug candidate, ALRN-6924, is currently undergoing multiple clinical trials, including Phase 2a studies for advanced solid tumors and peripheral T-cell lymphoma, as well as Phase 1 trials for acute myeloid leukemia and advanced myelodysplastic syndrome. Aileron is also working on a next-generation wild type p53 reactivator. Collaborations with notable institutions, such as Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Pfizer, further enhance its research efforts, particularly in evaluating ALRN-6924 in combination therapies. Aileron Therapeutics was founded in 2001, originally named Renegade Therapeutics, and is headquartered in Watertown, Massachusetts.

Activate Networks

Series B in 2012
Activate Networks, Inc. is a network analytics company focused on identifying and understanding key social connections that influence commercial, organizational, and health outcomes. The company offers a suite of analytics products and software that helps organizations leverage existing data to uncover the commercial value of their customer, prospect, voter, and employee social networks. By mapping and analyzing these networks, Activate Networks serves various industry sectors, including healthcare, technology, political campaigns, and professional services. Its proprietary RealConnect™ platform provides unique, actionable insights that enhance marketing campaigns, health-behavior change initiatives, talent management, and innovation efforts. Through its technology, Activate Networks enables users to recognize connections among customers, employees, and professional communities, thereby driving measurable impact across multiple domains.

Cleveland HeartLab

Series B in 2012
Cleveland HeartLab, Inc. is a clinical reference laboratory dedicated to the prevention of cardiovascular disease (CVD) through innovative biomarker technologies and proprietary diagnostic tests. The company specializes in the early identification of individuals at risk for CVD, emphasizing the management and reduction of inflammation. Cleveland HeartLab provides a range of clinical laboratory services, including an inflammatory panel for CVD, an advanced CVD risk profile, and lipid testing. By focusing on novel molecular biomarkers, the company aims to enhance disease management and improve patient outcomes in cardiovascular health.

IlluminOss

Series C in 2012
IlluminOss Medical, Inc. is a medical device company specializing in the development of minimally invasive orthopedic systems for fracture repair and stabilization. Founded in 2007 and based in East Providence, Rhode Island, the company offers a unique technology that utilizes a light-curable polymer within an expandable balloon catheter to create patient-specific intramedullary implants. This innovative approach is particularly beneficial for treating osteoporotic and compromised bone, providing a fast and effective method for bone stabilization. The IlluminOss system is CE-marked and FDA-cleared for use in various anatomical sites, with additional indications currently under review. IlluminOss markets its products through distributors in several countries, including Austria, Germany, Israel, and the United Kingdom.

Pathogenetix

Series B in 2011
PathoGenetiX is developing an automated system for the rapid identification of pathogenic bacterial strains using proprietary Genome Sequence Scanning Technology. The company's approach, which employs a single reagent set to generate genomic bar codes based on bacterial DNA, can cost-effectively identify thousands of strains in a single test from complex samples in three hours. PathoGenetiX is developing its GSS platform for use in genomics research, food and product safety testing, and clinical infectious disease diagnostics, with the initial commercial introduction into the research market planned for 2012.

MedVentive

Series D in 2011
MedVentive specializes in technology solutions that enhance the quality and cost-effectiveness of healthcare delivery. Founded by physicians in 1997, the company focuses on providing intervention and information solutions for healthcare delivery networks, payers, and employer coalitions. Its offerings include quality management, registries, pharmacy management, clinical integration, and managed care performance. Additionally, MedVentive provides point-of-care decision support and a pay-for-performance solution that calculates and tracks clinical measures, delivering tailored intervention recommendations for patients. Through these innovative tools, MedVentive aims to facilitate meaningful improvements in healthcare outcomes and reduce overall costs.

Aventura Software

Series A in 2011
Aventura intelligently orchestrates assets, people, and systems to deliver the right information at the right time based on location and credentials. It locates and re-assigns the closest online printer and uniquely manages print routing to make it easier to detect and fix printing failures. Aventura was formed in 2007 and headquartered in Denver, Colorado.

Lantos

Venture Round in 2011
Lantos Technologies, Inc. specializes in 3D digital ear scanning technology that facilitates the creation of personalized in-ear devices. The company offers the AURA 3D ear scanning system, which is utilized for designing in-ear headphones, musicians' monitors, hearing aids, and noise protection solutions. Lantos Technologies is recognized for having the only FDA-cleared 3D ear scanning system, which enhances the quality and efficiency of custom ear products by capturing detailed measurements from the outer ear to the second bend of the ear canal. Founded in 2009 and based in Derry, New Hampshire, the company was formerly known as Lantos 2.0 Inc. before rebranding in December 2020.

Cleveland HeartLab

Series B in 2011
Cleveland HeartLab, Inc. is a clinical reference laboratory dedicated to the prevention of cardiovascular disease (CVD) through innovative biomarker technologies and proprietary diagnostic tests. The company specializes in the early identification of individuals at risk for CVD, emphasizing the management and reduction of inflammation. Cleveland HeartLab provides a range of clinical laboratory services, including an inflammatory panel for CVD, an advanced CVD risk profile, and lipid testing. By focusing on novel molecular biomarkers, the company aims to enhance disease management and improve patient outcomes in cardiovascular health.

Pathogenetix

Series B in 2011
PathoGenetiX is developing an automated system for the rapid identification of pathogenic bacterial strains using proprietary Genome Sequence Scanning Technology. The company's approach, which employs a single reagent set to generate genomic bar codes based on bacterial DNA, can cost-effectively identify thousands of strains in a single test from complex samples in three hours. PathoGenetiX is developing its GSS platform for use in genomics research, food and product safety testing, and clinical infectious disease diagnostics, with the initial commercial introduction into the research market planned for 2012.

NanoMR

Series B in 2011
NanoMR specializes in the development of blood diagnostic devices, focusing on the rapid isolation of rare cells from complex biological samples at concentrations as low as one cell per milliliter. The company's innovative immunomagnetic capture system allows for the simultaneous targeting of multiple cell types, enabling the efficient extraction of bacteria and fungi in cases of bloodstream infections, as well as specific cells such as circulating tumor or fetal cells. This process is completed in under 30 minutes, significantly enhancing the speed and accuracy of diagnostics in clinical settings.

Springleaf Therapeutics

Series B in 2011
SpringLeaf Therapeutics (formerly known as Entra Pharmaceuticals, Inc.) is creating innovative therapeutic modalities to address serious disease and elevate the quality of care for patients. SpringLeaf's technology is based on convergent science and is designed to enable and differentiate therapeutics. SpringLeaf was founded based on breakthrough science at MIT and is backed by leading investors including Flybridge Capital Partners and North Bridge Venture Partners.

Catch.com

Series A in 2011
Catch.com (formerly Snaptic) is a market leader for Android smartphones and tablets. Millions have downloaded our mobile apps, including Catch Notes, AK Notepad and Compass. Our mobile apps also run on iOS and the web, and we are just getting started. Catch.com was founded in 2008 and is on the cusp of a seismic shift driven by growth in smartphone use -- reinventing how people interact, collaborate and discover what’s important to them.

Lantos

Venture Round in 2010
Lantos Technologies, Inc. specializes in 3D digital ear scanning technology that facilitates the creation of personalized in-ear devices. The company offers the AURA 3D ear scanning system, which is utilized for designing in-ear headphones, musicians' monitors, hearing aids, and noise protection solutions. Lantos Technologies is recognized for having the only FDA-cleared 3D ear scanning system, which enhances the quality and efficiency of custom ear products by capturing detailed measurements from the outer ear to the second bend of the ear canal. Founded in 2009 and based in Derry, New Hampshire, the company was formerly known as Lantos 2.0 Inc. before rebranding in December 2020.

ShapeUp

Series A in 2010
ShapeUp is the leading provider of clinically-proven social networking-powered corporate wellness solutions. ShapeUp covers more than 2 million lives on its online platform and serves more than 500 employers and health plans in 109 countries. It was founded in 2006 and headquartered in Providence, Rhode Island.

Viridos

Venture Round in 2010
Viridos is a biotechnology company focused on developing genomic-driven solutions to address global energy and environmental challenges. It utilizes a proprietary RNA replicon platform to stimulate the immune system and deliver targeted therapies produced within the body. The company synthesizes and programs DNA to design and develop microbes for various industrial processes, including bioenergy applications. Its portfolio includes algal-based biodiesel and microbial cultivation technologies that enhance the production and recovery rates of subsurface hydrocarbons. Viridos is also engaged in creating advanced biofuels and harnessing photosynthetic organisms to produce value-added products from sunlight and carbon dioxide. Additionally, it develops biologics such as monoclonal antibodies and therapeutic enzymes, serving clients in the pharmaceutical and biotech sectors, as well as contract manufacturing organizations. Founded in 2005 and based in La Jolla, California, the company aims to improve energy production, chemical synthesis, and pharmaceutical development while contributing to carbon sequestration and environmental remediation efforts.

Catch.com

Seed Round in 2010
Catch.com (formerly Snaptic) is a market leader for Android smartphones and tablets. Millions have downloaded our mobile apps, including Catch Notes, AK Notepad and Compass. Our mobile apps also run on iOS and the web, and we are just getting started. Catch.com was founded in 2008 and is on the cusp of a seismic shift driven by growth in smartphone use -- reinventing how people interact, collaborate and discover what’s important to them.
Tetraphase Pharmaceuticals, Inc. is a biopharmaceutical company focused on developing and commercializing novel antibiotics to combat serious multidrug-resistant infections. Its primary product candidate, Xerava (eravacycline), is a synthetic fluorocycline designed for intravenous use as a first-line treatment for multidrug-resistant infections, particularly those caused by Gram-negative bacteria. The company has conducted Phase III clinical trials, including IGNITE1 and IGNITE4, to evaluate Xerava's safety and efficacy for treating complicated intra-abdominal infections. In addition to Xerava, Tetraphase is advancing other product candidates, such as TP-271, which targets respiratory diseases caused by antibiotic-resistant pathogens, and TP-6076, aimed at treating multidrug-resistant Gram-negative infections. The company holds a licensing agreement with Everest Medicines Limited to develop and commercialize Xerava in various Asian markets. Founded in 2006 and headquartered in Watertown, Massachusetts, Tetraphase Pharmaceuticals is a subsidiary of La Jolla Pharmaceutical Company.

Intrapace

Venture Round in 2010
IntraPace, Inc. specializes in the development and marketing of implantable devices aimed at treating obesity. Founded in 2001 and located in Mountain View, California, the company has created the abiliti system, which stimulates a satiety response to facilitate weight loss. This innovative device is based on technology commonly used in cardiac pacemakers and defibrillators, allowing for implantation through standard laparoscopic methods. Notably, the abiliti system does not alter the digestive system's anatomy and imposes no restrictions on a patient's dietary intake, making it a versatile option for individuals seeking weight management solutions.

Saladax Biomedical

Series C in 2010
Saladax Biomedical, Inc. focuses on developing and commercializing diagnostic blood tests aimed at enhancing personalized medicine in psychiatry and oncology. Established in 2004 and based in Bethlehem, Pennsylvania, the company offers a range of products under its MyCare line, including MyCare Psychiatry for determining appropriate antipsychotic dosages, MyCare Oncology for optimizing chemotherapy exposure, and MyCare Neurology for assessing neurological drug effects. Key products include My5-FU, MyPaclitaxel, MyDocetaxel, and MyImatinib, which assist healthcare professionals in personalizing treatment for various cancers and other conditions. Saladax markets its tests globally through distributors and direct sales in selected regions, striving to provide rapid and cost-effective solutions that allow clinicians to optimize drug dosing based on individual patient needs.

TransMedics

Series E in 2010
TransMedics is a medical technology company focused on improving organ transplant therapy for patients with end-stage organ failure. Headquartered in Andover, Massachusetts, it has developed the Organ Care System (OCS), a portable organ perfusion and monitoring device that mimics near-physiologic conditions for donor organs outside the human body. This system includes specialized devices for different organs, such as OCS LUNG, which maintains lungs in a viable state for assessment and optimization, OCS Heart, designed to preserve hearts in a metabolically active state, and OCS Liver, currently under clinical trials. By addressing the limitations of traditional cold storage methods, TransMedics aims to enhance organ preservation and increase the availability of organs for transplantation, thereby improving outcomes for patients in need. Founded in 1998, the company is at the forefront of innovation in organ transplant technology.

Biocius Life Sciences

Seed Round in 2010
Biocius Life Sciences, Inc. is a company specializing in drug discovery research, established in 2009 and located in Woburn, Massachusetts. As a subsidiary of BioTrove, Inc., Biocius develops advanced technologies, including high-throughput mass spectrometry systems, to facilitate the drug discovery process. The company's innovative approach aims to enhance efficiency and accuracy in identifying potential therapeutic compounds, contributing to advancements in pharmaceutical research and development.

Virgin Pulse

Venture Round in 2010
Virgin Pulse, part of Sir Richard Branson’s Virgin Group, designs technology that cultivates good lifestyle habits for your employees. Configured to complement your culture, our technology, and the overall well-being experience we deliver, drives superior outcomes for your people and your business. Virgin – one of the world’s most recognized and respected brands – is known for creating unrivaled consumer experiences. Conceived in 1970 by Branson, the brand believes in insatiable curiosity, smart disruption, heartfelt service, and delightful experiences.

MedVentive

Series C in 2009
MedVentive specializes in technology solutions that enhance the quality and cost-effectiveness of healthcare delivery. Founded by physicians in 1997, the company focuses on providing intervention and information solutions for healthcare delivery networks, payers, and employer coalitions. Its offerings include quality management, registries, pharmacy management, clinical integration, and managed care performance. Additionally, MedVentive provides point-of-care decision support and a pay-for-performance solution that calculates and tracks clinical measures, delivering tailored intervention recommendations for patients. Through these innovative tools, MedVentive aims to facilitate meaningful improvements in healthcare outcomes and reduce overall costs.

Exact Sciences

Post in 2009
Exact Sciences Corporation is a molecular diagnostics company based in Madison, Wisconsin, specializing in cancer screening and diagnostic tests both in the United States and internationally. The company is best known for Cologuard, a non-invasive stool-based DNA test designed to detect colorectal cancer and pre-cancer. Additionally, Exact Sciences offers Oncotype DX, a suite of gene expression tests that assess recurrence risk and potential chemotherapy benefits for breast, prostate, and colon cancers. The company is also engaged in developing liquid biopsy tests for various applications, including the detection of molecular residual disease and enhanced colorectal cancer screening. Exact Sciences holds exclusive intellectual property for its screening technologies, which are recognized in the colorectal cancer screening guidelines established by the American Cancer Society and other medical organizations.

Aileron Therapeutics

Series D in 2009
Aileron Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing and commercializing a novel class of drugs known as stabilized cell-permeating alpha-helical peptides, particularly in the field of oncology. The company’s lead drug candidate, ALRN-6924, is currently undergoing multiple clinical trials, including Phase 2a studies for advanced solid tumors and peripheral T-cell lymphoma, as well as Phase 1 trials for acute myeloid leukemia and advanced myelodysplastic syndrome. Aileron is also working on a next-generation wild type p53 reactivator. Collaborations with notable institutions, such as Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Pfizer, further enhance its research efforts, particularly in evaluating ALRN-6924 in combination therapies. Aileron Therapeutics was founded in 2001, originally named Renegade Therapeutics, and is headquartered in Watertown, Massachusetts.

BioTrove

Series C in 2009
BioTrove, Inc. specializes in micro and nano-scale technology platforms aimed at advancing life science and drug discovery research. The company has developed innovative systems that include the OpenArray platform, which facilitates relative gene expression analysis to support genomic research across various fields such as agriculture, disease research, and public health. Additionally, BioTrove offers the RapidFire platform, designed for screening difficult drug targets through mass spectrometry-based assay development, alongside its RapidFire mass spectrometry hardware system that serves as a native detection technology for drug screening and in vitro absorption, distribution, metabolism, and excretion (ADME) applications. These technologies enable rapid and efficient analysis, enhancing the research process and fostering development in molecular diagnostics and high-throughput screening.

Xcellerex

Venture Round in 2009
Xcellerex is a supplier of manufacturing technologies, developing and producing biomanufacturing systems and production-scale bioreactors. The biomanufacturing solutions transform the speed and economics of producing therapeutic proteins, including biosimilars and vaccines. Its proprietary products offer significant advantages such as faster installation, lower capital investment, reduced risk of cross-contamination, and significantly increased flexibility compared with traditional manufacturing technologies. The company’s FlexFactory® is a completely modular and portable production train based on single-use technologies, advanced process automation, and compact cleanroom architecture. In 2002, the company was founded by Parrish M. Galliher inMarlborough, Massachusetts.

Carefx

Venture Round in 2009
Carefx is a provider of information technology solutions specifically designed for healthcare organizations in North America and Europe. The company's primary offering, Fusionfx, is an interoperable workflow and analytics solution that addresses information gaps between healthcare executives and IT departments. By synthesizing disparate data into clinically relevant, user-centric workflows, Fusionfx connects care providers with essential information, enhancing both clinical and business operations. Additionally, the solution includes business intelligence dashboards that promote accountability and transparency within healthcare organizations, thereby improving the overall efficiency and effectiveness of patient care.

Zonare Medical Systems

Venture Round in 2008
Zonare Medical Systems, Inc. specializes in the development and manufacturing of compact ultrasound systems utilized for diagnostic imaging across various clinical applications. Central to its offerings is the z.one ultrasound system, which incorporates the proprietary Zone Sonography technology, allowing for enhanced data acquisition and image formation. This technology enables clients to maintain their ultrasound systems while also integrating new clinical applications and advanced imaging capabilities. Zonare Medical markets its products through a direct sales force in the United States and a mix of distributors and direct sales personnel in around 40 international markets. Founded in 1999 and headquartered in Mountain View, California, the company aims to provide innovative and accessible medical technologies tailored to the needs of healthcare professionals.

Skylight

Series C in 2008
Skylight Tools, Inc. operates a digital platform that simplifies the process of home renovations by connecting users with general contractors. Founded in 2016 and based in San Francisco, the company offers a comprehensive renovation management tool that assists clients in selecting contractors, managing budgets, and tracking project progress. Their application facilitates payment processing, invoice reconciliation, and real-time updates on project status. Skylight also provides a financial guarantee, covering half of any budget overruns exceeding 10%. The company aims to enhance the renovation experience through a fully integrated digital process that encompasses planning, material selection, permitting, and construction, specifically targeting the challenges associated with traditional renovation methods.

Passport Health Communications

Venture Round in 2008
Passport Health Communications, Inc., a software-as-a-service company, provides revenue cycle management solutions and platforms. The company offers eCare Patient Access Suite, including solutions for patient demographic and insurance verification, compliance, and managing patient payments; OrderChecker that validates outpatient diagnosis and procedure codes; and IntelliSource, an integrated patient access system. It also provides OneSource, a Web-based user interface, which enables to verify patient demographic and insurance information, identify coverages, maintain payer compliance, and estimate and collect patient payments; BatchSource that allows for automation to upload, process, and download files for various transactions across the revenue cycle; and Registration Quality Assurance, a Web-based integrated solution, which automatically launches insurance eligibility real-time. In addition, the company offers Patient Payment Estimator that calculates estimates based on price information; eCashiering, a solution for processing patient payments prior to or at the point of service; Claims Management Suite, which provides solutions and services for claims submission, editing, denials, and reimbursements; Payment Navigator, an automated financial screening tool; and OrderRite, a single-user interface to submit, validate, and manage pre-certifications. Further, it provides patient verification, compliance, and payment management services. The company serves health care organizations, including hospitals, physician offices, surgery centers, durable medical equipment facilities, and skilled nursing facilities. Passport Health Communications was formerly known as InterMed, LLC and changed its name to Passport Health Communications, Inc. in 1998. The company was founded in 1996 and is headquartered in Franklin, Tennessee. Passport Health Communications, Inc. operates as a subsidiary of Passport Holding, Corp.

IPC-The Hospitalist Company

Venture Round in 2008
IPC is the nation's leading national physician group practice focused on the delivery of hospital medicine and related facility-based services. IPC providers manage the care of patients in coordination with primary care physicians and specialists in over 1,100 facilities in 28 states across the U.S. We provide care to over 1 million patients annually while maintaining high standards of quality care, aligning with the mission and objectives of the facilities where we serve.

Emageon

Post in 2008
Emageon provides an enterprise-level information technology solution for the clinical analysis and management of digital medical images within health care provider organizations.

ForHealth Technologies

Venture Round in 2008
ForHealth Technologies specializes in developing automation technology solutions specifically for intravenous drug preparation. Founded in 1998 and based in Daytona Beach, Florida, the company aims to enhance the efficiency and safety of medication preparation processes. In March 2009, ForHealth Technologies was acquired by Baxa Corporation, further integrating its innovative solutions into the healthcare sector.

Virscio

Venture Round in 2008
RxGen, Inc. is a biotechnology company that develops therapeutics for central nervous system disorders such as neurodegeneration, memory loss, and obesity. The company utilizes PrimaTox, which is a predictive toxicogenomics platform that enables pharmaceutical candidate selection and pre-clinical validation. RxGen is based in Hamden, Connecticut.

CareMedic Systems

Venture Round in 2008
CareMedic Systems, Inc. provides revenue cycle management solutions to hospitals and healthcare providers in the United States and Puerto Rico. It offers electronic Financial Record, a healthcare financial management system that provides activity tracking capabilities, and recording descriptions and dates for various events that occur inside or outside the patient accounting system; and VerifyAR, a solution for front-end document management, eligibility verification, compliance checking, and medical necessity review. The company also provides AccelerateAR, a Medicare review and editing solution with document management, all-payer claims formatting and submission, and print and mail service capabilities; and OptimizeAR, a solution that offers tools for managing payments through remittance management, denial management, and paper EOB to electronic 835 conversions. In addition, it offers ImageAR, a document management system with integrated front and back-end scanning, indexing, and storage solutions that enable and streamline various revenue cycle functions; and ResolveAR, a suite of service offerings, including accounts receivables outsourcing, Medicare accounts receivables cleanup, and credit balance resolution. The company provides its solutions in application service provider (ASP) model. CareMedic Systems, Inc. was founded in 1996 and is based in St. Petersburg, Florida with additional offices in Alpharetta and Decatur, Georgia.
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