Areteia Therapeutics is a biotechnology company focused on improving the management of eosinophilic asthma through an innovative oral drug treatment. The company, which emerged from Knopp, aims to provide patients with a novel therapeutic option that inhibits the maturation of eosinophils—cells that can cause airway damage in asthma patients. Its drug candidate has demonstrated promising results in a phase 2 clinical trial, which showed a reduction in blood eosinophil counts, indicating enhanced lung function. This approach seeks to empower patients by offering a potentially effective and accessible treatment for a severe form of asthma, thereby improving their quality of life and disease management.
Third Pole, Inc. is a Waltham, Massachusetts-based company that specializes in developing an innovative inhaled nitric oxide therapy delivery system. This system produces pure inhalable nitric oxide from air, offering a tankless and clean alternative for therapeutic use in hospitals, ambulatory settings, and at home. The technology is designed to address critical medical conditions such as hypoxia in newborns, malaria, heart attacks, and strokes. Although nitric oxide has proven efficacy in treating hypoxic newborns, its availability is limited and often inaccessible in many regions. Third Pole aims to make this essential therapy widely available across the globe, thereby improving health outcomes for patients in need. The company was incorporated in 2014 and focuses on advancing the delivery of nitric oxide therapy to enhance patient care.
YieldStreet Management, LLC is a principal investment firm based in New York that focuses on providing access to asset-based investments typically unavailable to most investors. The firm aims to democratize investment opportunities by allowing accredited investors to participate in curated, high-yield investments with low correlation to traditional markets. YieldStreet's digital wealth management platform connects investors with diverse alternative asset classes, including litigation finance and real estate, while also offering borrowers access to affordable capital. Through this innovative approach, YieldStreet seeks to promote prosperity for all participants in the investment landscape.
Trunomi, Inc. operates a consent-based data-sharing platform aimed at enhancing customer verification processes for financial industry clients in the U.S. and internationally. Founded in 2014 and based in Campbell, California, Trunomi enables customers to digitally manage and share their personal data through a secure personal data store, ensuring compliance with data privacy regulations. The platform allows businesses to understand the data they hold, comply with global regulations, and automate data subject request management. Notably, Trunomi's patented technology does not store customer personal data, ensuring a zero-risk solution that operates beyond jurisdictional data boundaries. The platform also supports secure messaging and document sharing, and is designed to improve customer experience by transforming privacy into a positive engagement.
YieldStreet Management, LLC is a principal investment firm based in New York that focuses on providing access to asset-based investments typically unavailable to most investors. The firm aims to democratize investment opportunities by allowing accredited investors to participate in curated, high-yield investments with low correlation to traditional markets. YieldStreet's digital wealth management platform connects investors with diverse alternative asset classes, including litigation finance and real estate, while also offering borrowers access to affordable capital. Through this innovative approach, YieldStreet seeks to promote prosperity for all participants in the investment landscape.
Kaleo Software, Inc. operates online platform that allows users to connect to other knowledge workers in an organization to extract, contribute, and share information. It operates an interactive knowledge network that puts the answers to essential business questions raised by users. Its platform captures and tags information to create an organically growing knowledge base; and enables users to find information based on input from co-workers and topic experts. The company was founded in 2011 and is based in El Segundo, California.
Alignable, Inc., founded in 2012 and based in Boston, Massachusetts, operates a social network tailored for small business owners to connect, collaborate, and thrive within their local communities. With over 3 million members across more than 30,000 local communities, it serves as the largest marketplace for small business networking, where owners can build trusted relationships and generate referrals. The platform facilitates the exchange of industry-specific advice and recommendations, allowing users to connect based on location, industry, and business needs. Through these interactions, members can enhance their visibility, increase word-of-mouth promotion, and ultimately drive revenue growth for their businesses.
Trunomi, Inc. operates a consent-based data-sharing platform aimed at enhancing customer verification processes for financial industry clients in the U.S. and internationally. Founded in 2014 and based in Campbell, California, Trunomi enables customers to digitally manage and share their personal data through a secure personal data store, ensuring compliance with data privacy regulations. The platform allows businesses to understand the data they hold, comply with global regulations, and automate data subject request management. Notably, Trunomi's patented technology does not store customer personal data, ensuring a zero-risk solution that operates beyond jurisdictional data boundaries. The platform also supports secure messaging and document sharing, and is designed to improve customer experience by transforming privacy into a positive engagement.
Omaze, Inc. operates an online fundraising platform that aims to make charitable giving engaging and accessible. Founded in 2011 and based in Culver City, California, the platform enables donors to participate in online auctions for unique prizes, such as experiences with celebrities, luxury vehicles, and exclusive travel packages. Omaze collaborates with influencers, athletes, and nonprofits to create compelling fundraising campaigns, providing the necessary resources for marketing, content creation, technology, and fulfillment. By offering once-in-a-lifetime opportunities, the platform not only raises funds but also increases awareness for various charitable initiatives, ultimately enhancing the impact of digital fundraising efforts.
Express KCS, Inc. specializes in providing creative outsourcing solutions and back office services tailored for corporations, media companies, FMCG businesses, publishers, retailers, and agencies. Founded in 2005 and headquartered in Pittsburgh, Pennsylvania, the company offers a comprehensive range of media-related back office functions, including creative design, advertising production, multimedia publishing, image editing, and video post-production. With facilities in New Delhi, India, and additional offices in San Jose, California, Milton Keynes, United Kingdom, and Gurugram, India, Express KCS supports clients in efficiently offshoring their media production needs. The company's client roster includes notable names in publishing and media, such as MediaNews and McClatchy, and it is recognized for delivering quality services that enhance cost efficiency without sacrificing standards.
Omaze, Inc. operates an online fundraising platform that aims to make charitable giving engaging and accessible. Founded in 2011 and based in Culver City, California, the platform enables donors to participate in online auctions for unique prizes, such as experiences with celebrities, luxury vehicles, and exclusive travel packages. Omaze collaborates with influencers, athletes, and nonprofits to create compelling fundraising campaigns, providing the necessary resources for marketing, content creation, technology, and fulfillment. By offering once-in-a-lifetime opportunities, the platform not only raises funds but also increases awareness for various charitable initiatives, ultimately enhancing the impact of digital fundraising efforts.
Alignable, Inc., founded in 2012 and based in Boston, Massachusetts, operates a social network tailored for small business owners to connect, collaborate, and thrive within their local communities. With over 3 million members across more than 30,000 local communities, it serves as the largest marketplace for small business networking, where owners can build trusted relationships and generate referrals. The platform facilitates the exchange of industry-specific advice and recommendations, allowing users to connect based on location, industry, and business needs. Through these interactions, members can enhance their visibility, increase word-of-mouth promotion, and ultimately drive revenue growth for their businesses.
Think Through Learning's key product line, Think Through Math, is America's leading online math remediation software. There are almost 3,000,000 students in over 180,000 classrooms who are paid subscribers to Think Through Math. Think Through Math is a unique SaaS system integrating student motivation, instant on-demand interventions from state-certified US math teachers, and award winning adaptive math instruction that teaches students higher order thinking skills. Winner of the 2014 and 2012 CODiE for Best Math Instructional Solution, Think Through Math is proven to raise students understanding of math. Each student starts with an adaptive placement test that moves them right to the math they need to learn. Extensive guided feedback supports them. When they are stuck, a U.S., state-cerfiied, classroom experienced math teacher will pop up within 10 seconds to tutor them in real time. A January, 2015 independent research study commissioned by the Texas Education Agency (TEA) of 755,440 students who used Think Through Math showed that students using the system on a regular basis improved their math scores an average of 23%. The study is available of the TEA website. Numerous other studies have proven Think Through Math significantly improves students understanding of math.
Chirpify, Inc. operates a social media loyalty platform that provides solutions for marketers to enhance consumer engagement and brand loyalty. Founded in 2011 and based in Portland, Oregon, Chirpify enables brands to convert mobile and social media actions into rewards through various initiatives, including consumer engagement loyalty programs and marketing chat bots. The platform facilitates "in-stream" marketing by allowing users to purchase items directly through social media interactions, promoting a seamless transaction process. Additionally, Chirpify's tools support campaign activation, employee advocacy, event marketing, and customer insights, helping brands optimize their marketing strategies and improve customer lifetime value. Formerly known as Sell Simply LLC, the company rebranded to Chirpify in November 2011.
BiOWiSH Technologies Inc. is a biotechnology company that develops, manufactures, and distributes solutions for environmental management, agriculture, and consumer products. Founded in 2007 and headquartered in Cincinnati, Ohio, the company offers a range of products aimed at wastewater treatment, waste management, odor control, soil and water remediation, and animal agriculture. BiOWiSH Technologies is known for its stable microbial formulations, which enhance nutrient management performance across various industries, including agriculture, aquaculture, and industrial cleaning. Its products are designed for consistent performance under diverse operating conditions, generating high concentrations of bioactive metabolites that act as effective agents in their respective applications.
Xpress Natural Gas LLC is a provider of compressed and liquefied natural gas, focusing on customers in the United States who are not connected to existing pipeline infrastructure. Founded in 2011 and headquartered in Boston, Massachusetts, the company operates a production facility and distribution terminal in Manheim, New York. Xpress Natural Gas serves industrial and commercial clients, as well as municipalities, by delivering natural gas solutions that can significantly reduce operational costs compared to traditional fuels. In addition to its delivery services, the company offers emergency support for utilities facing pipeline constraints. By leveraging a network of compression stations and high-capacity trailers, Xpress Natural Gas aims to facilitate the transition to cleaner energy sources for its clients.
Knopp Biosciences LLC is a biotechnology company based in Pittsburgh, Pennsylvania, focused on discovering and developing innovative treatments for inflammatory and neurological diseases. Founded in 2004, the company is engaged in clinical programs targeting inflammation and hematology, including dexpramipexole, an anti-inflammatory therapeutic that modulates white blood cells. Additionally, Knopp has a hematology discovery program aimed at selectively arresting eosinophil maturation with orally available medications. The company also explores a KCNQ2 preclinical program, which seeks to activate a crucial ion channel in nerve cells, addressing conditions such as neonatal encephalopathy, epilepsy, and neuropathic pain. Furthermore, Knopp is developing small molecule modulators to enhance mitochondrial efficiency as part of its mitochondrial discovery program. Through its focused research and development efforts, Knopp Biosciences aims to provide breakthrough treatments that improve patient outcomes and address significant healthcare challenges.
Think Through Learning's key product line, Think Through Math, is America's leading online math remediation software. There are almost 3,000,000 students in over 180,000 classrooms who are paid subscribers to Think Through Math. Think Through Math is a unique SaaS system integrating student motivation, instant on-demand interventions from state-certified US math teachers, and award winning adaptive math instruction that teaches students higher order thinking skills. Winner of the 2014 and 2012 CODiE for Best Math Instructional Solution, Think Through Math is proven to raise students understanding of math. Each student starts with an adaptive placement test that moves them right to the math they need to learn. Extensive guided feedback supports them. When they are stuck, a U.S., state-cerfiied, classroom experienced math teacher will pop up within 10 seconds to tutor them in real time. A January, 2015 independent research study commissioned by the Texas Education Agency (TEA) of 755,440 students who used Think Through Math showed that students using the system on a regular basis improved their math scores an average of 23%. The study is available of the TEA website. Numerous other studies have proven Think Through Math significantly improves students understanding of math.
Panopto, Inc. is a developer of a comprehensive video software platform aimed at the corporate and education sectors. Founded in 2007 and headquartered in Seattle, the company specializes in creating searchable video libraries that facilitate the management and dissemination of institutional knowledge. Its platform includes functionalities for video content management, live streaming, video analytics, and video recording, as well as tools for online editing and remote recording. Panopto's solutions support a range of applications, such as lecture capture, employee training, and live events, enhancing active learning and knowledge sharing. The company has received recognition for its innovation and rapid growth, with additional offices in locations including Pittsburgh, London, Sydney, and Hong Kong.
Knopp Biosciences LLC is a biotechnology company based in Pittsburgh, Pennsylvania, focused on discovering and developing innovative treatments for inflammatory and neurological diseases. Founded in 2004, the company is engaged in clinical programs targeting inflammation and hematology, including dexpramipexole, an anti-inflammatory therapeutic that modulates white blood cells. Additionally, Knopp has a hematology discovery program aimed at selectively arresting eosinophil maturation with orally available medications. The company also explores a KCNQ2 preclinical program, which seeks to activate a crucial ion channel in nerve cells, addressing conditions such as neonatal encephalopathy, epilepsy, and neuropathic pain. Furthermore, Knopp is developing small molecule modulators to enhance mitochondrial efficiency as part of its mitochondrial discovery program. Through its focused research and development efforts, Knopp Biosciences aims to provide breakthrough treatments that improve patient outcomes and address significant healthcare challenges.
Knopp Biosciences LLC is a biotechnology company based in Pittsburgh, Pennsylvania, focused on discovering and developing innovative treatments for inflammatory and neurological diseases. Founded in 2004, the company is engaged in clinical programs targeting inflammation and hematology, including dexpramipexole, an anti-inflammatory therapeutic that modulates white blood cells. Additionally, Knopp has a hematology discovery program aimed at selectively arresting eosinophil maturation with orally available medications. The company also explores a KCNQ2 preclinical program, which seeks to activate a crucial ion channel in nerve cells, addressing conditions such as neonatal encephalopathy, epilepsy, and neuropathic pain. Furthermore, Knopp is developing small molecule modulators to enhance mitochondrial efficiency as part of its mitochondrial discovery program. Through its focused research and development efforts, Knopp Biosciences aims to provide breakthrough treatments that improve patient outcomes and address significant healthcare challenges.
ReefEdge, Inc. specializes in wireless local area network systems tailored for multi-site enterprises, enabling them to deploy, manage, and secure their wireless networks effectively. Founded in 2000, the company develops advanced technologies for in-building wireless networks, facilitating the integration of mobile devices into corporate environments. ReefEdge's products ensure secure and reliable connectivity for mobile devices utilizing short-range wireless capabilities, such as Bluetooth. This connectivity supports the deployment of innovative mobile applications that offer personalized, location-aware, and collaborative services. The company's leadership team comprises experienced professionals from notable organizations, bringing a wealth of expertise in delivering solutions to enterprise customers.
BodyMedia, founded in 1999 and based in Pittsburgh, PA, specializes in wearable body monitoring devices that gather physiological data to enhance health, wellness, and fitness. The company offers a range of continuous on-body monitors that utilize proprietary technology validated for clinical accuracy. These devices serve both consumers and health professionals, facilitating behavioral adjustments aimed at weight management and active living—critical factors in addressing serious health issues. BodyMedia's products include a calorie management system that tracks calories burned against those consumed, alongside body monitoring systems that record various physiological metrics analyzed through its SenseWear software. The company has contributed significantly to health research, participating in over 100 clinical studies related to obesity, diabetes, and other medical conditions, thereby creating one of the largest databases of human physiological information.