HealthCor Partners Management

Mineralys Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing innovative therapies for hypertension. The company is advancing its lead product candidate, MLS-101, a highly selective and potent aldosterone synthase inhibitor licensed from Mitsubishi Tanabe Pharma Corporation. Mineralys aims to provide a targeted treatment for patients with uncontrolled hypertension, particularly those who do not achieve adequate blood pressure control despite using multiple antihypertensive medications. By addressing the underlying factors associated with elevated aldosterone levels, Mineralys seeks to improve treatment outcomes for individuals suffering from this condition.

DNA Script SAS, founded in 2014 and based in Paris, France, specializes in synthetic biology tools and innovative DNA synthesis technology. The company has developed a groundbreaking enzymatic technology that powers the SYNTAX, the world's first benchtop DNA printer. This device allows laboratories to produce synthetic oligonucleotides on-site, significantly enhancing workflow control and expediting access to results. By employing an efficient biochemical process for nucleic acid synthesis, DNA Script enables researchers to rapidly generate essential genomic materials, such as oligonucleotides, which are crucial for genomics and molecular biology applications. Through its advancements, DNA Script aims to facilitate breakthroughs in life sciences and human health.

Acrivon Therapeutics is a clinical-stage biopharmaceutical company focused on developing oncology medicines tailored to individual patients. The company employs a proteomics-based platform to identify patients whose tumors are likely to respond to specific treatments, thereby enhancing the effectiveness of drug development. Acrivon's lead program is ACR-368, also known as prexasertib, which is currently in Phase 2 trials. Additionally, the pipeline includes preclinical programs that target critical components of the DNA Damage Response and cell cycle regulation pathways, specifically focusing on proteins such as WEE1 and PKMYT1. By leveraging these innovative approaches, Acrivon aims to improve therapeutic outcomes for cancer patients.

Imperative Care, Inc. is dedicated to enhancing the speed and effectiveness of acute stroke treatment through innovative medical technologies. Founded in 2015 and based in Campbell, California, the company has developed a range of solutions aimed at addressing critical needs in stroke care. Among its offerings is the Large Distal Platform, a large diameter catheter designed to reach treatment sites for both ischemic and hemorrhagic strokes. Complementing this is the ZOOM Aspiration System, a comprehensive solution that works in conjunction with the Large Distal Platform and includes various trackable reperfusion catheters for effective clot removal. By advancing stroke treatment technologies, Imperative Care aims to improve patient outcomes and optimize recovery processes for those affected by strokes.

Ikena Oncology is dedicated to bringing next generation oncology therapies to patients suffering from cancer. Ikena Oncology are committed to leveraging our unique understanding of the complex biologic pathways that drive the formation and spread of cancers to discover and develop novel, patient-directed therapies. Selecting patients for treatment in clinical studies with biomarkers we develop is at the core of our strategy.

Paige builds software to advance the diagnosis, treatment, and biomarker discovery for cancer. The Memorial Sloan Kettering spin-out aims to help pathologists and clinicians make faster, more informed diagnostic and treatment decisions and to bring new digital biomarkers to their practice. Paige’s proprietary Machine Learning solutions provide insights from decades of data from the world’s experts in cancer care and were recently published in Nature Medicine. The company’s first product for prostate cancer detection received Breakthrough Designation from the FDA as a novel therapy that stands to improve diagnostic accuracy while reducing costs to health systems.

Paige builds software to advance the diagnosis, treatment, and biomarker discovery for cancer. The Memorial Sloan Kettering spin-out aims to help pathologists and clinicians make faster, more informed diagnostic and treatment decisions and to bring new digital biomarkers to their practice. Paige’s proprietary Machine Learning solutions provide insights from decades of data from the world’s experts in cancer care and were recently published in Nature Medicine. The company’s first product for prostate cancer detection received Breakthrough Designation from the FDA as a novel therapy that stands to improve diagnostic accuracy while reducing costs to health systems.

Claret Medical, Inc. is a cardiovascular medical device company that specializes in developing cerebral vascular protection systems for transcatheter aortic valve implantation and various endovascular procedures. Its flagship product, the Claret Medical Sentinel Cerebral Protection System, is a percutaneously delivered embolic protection device designed to capture and remove debris that may be dislodged during these procedures. Additionally, the company offers small 6 French catheters that are inserted through an artery in the patient's right arm and guided toward the heart, facilitating the protection of the cerebral vascular system from potential embolic material. Founded in 2009 and based in Santa Rosa, California, Claret Medical operates as a subsidiary of Boston Scientific Corporation, focusing on enhancing patient safety during interventional cardiovascular treatments.

PreemaTEX is the developer of an innovative, high value diagnostic tests focused on assessing a woman’s risk for preterm delivery early in pregnancy.

ReShape Medical Inc. is a medical device company specializing in non-surgical weight loss solutions for individuals with mild to moderate obesity, specifically those with a Body Mass Index (BMI) of 30-40. The company offers the ReShape procedure, which utilizes a dual intragastric balloon system combined with a personalized one-year weight loss program, aimed at facilitating weight loss through lifestyle changes. This procedure is designed for adult patients who have not achieved success with diet and exercise alone. ReShape Medical operates through medical weight loss centers and is based in San Clemente, California. Originally founded as Abdominis, Inc. in 2005, the company was rebranded and operates as a subsidiary of ReShape Lifesciences Inc. The broader product portfolio of its parent company includes other minimally invasive devices for treating obesity and metabolic diseases.

Natera is a diagnostic and research company specializing in genetic testing services, primarily focused on preconception and prenatal testing. Its flagship product, Panorama, is a non-invasive prenatal test that screens for chromosomal abnormalities in fetuses through a blood draw from the mother, including assessments for twin pregnancies. Other offerings include Vistara, which tests for single-gene disorders, and Horizon carrier screening to identify carrier status for various genetic diseases. Natera also provides the Anora test for analyzing fetal chromosomes in cases of miscarriage and non-invasive paternity testing. Additionally, the company has developed Signatera, a technology that detects circulating tumor DNA to monitor cancer recurrence. Natera utilizes a direct sales force and a network of approximately 100 laboratory and distribution partners for product distribution. The company was founded in 2003, has undergone several name changes, and is headquartered in San Carlos, California. Its collaborations with organizations like BGI Genomics and Foundation Medicine further enhance its capabilities in genetic testing and personalized medicine.

CareView Communications develops a proprietary network system designed for healthcare facilities, utilizing existing coaxial cable infrastructure to enhance patient safety and operational efficiency. The company's offerings include real-time patient monitoring, which features Virtual Bed Rails and Virtual Chair Rails to prevent falls proactively. Additionally, CareView's bed management program provides a real-time dashboard for tracking bed status, aiding in patient placement and preventing overcrowding. The CareView Mobile application allows nursing staff to manage patient care conveniently from mobile devices, facilitating efficient communication through voice, text, and email. The company also enhances patient satisfaction through entertainment features and a patient education portal, providing easy access to informative resources for patients and their families. Overall, CareView Communications aims to improve hospital communications and operations while fostering a safer and more satisfying patient experience.

Sadra Medical is dedicated to creating innovative, minimally invasive alternatives to traditional surgical valve replacement, specifically targeting the treatment of aortic valve disease. The company aims to address the significant clinical need for effective therapies, as aortic valve stenosis affects approximately 3 million individuals in the United States, yet only a small percentage receive treatment through conventional open-heart surgery. By developing new devices that facilitate these advanced procedures, Sadra Medical seeks to enhance patient care and make valve replacement accessible to a broader range of patients. The company's goal is to reduce the risks and complications associated with open surgical procedures, providing a viable therapeutic option for those who currently lack effective treatment.

ApaTech Ltd., an ortho-biologics company, produces synthetic bone repair materials. It offers Actifuse, a synthetic bone graft, which creates a material that promotes the formation of bone and increases the volume of bone formed in the graft/host bone composite structures for small void filling and spinal fusion applications. The company also provides ApaPore, a synthetic and porous hydro-xyapatite grafting for the cemented revision of failed total joint arthroplasties for spinal fusions and fracture fixations, as well as for treating bone defects; and Actifuse MIS Bone Graft Delivery System that offers controlled delivery and precise placement for surgeons performing open and minimally invasive procedures, as well as for use in various spinal and orthopedic procedures, including posterolateral fusion, bone void filling, and acetabular cysts. It offers its products through distributors in the United Kingdom, Ireland, Norway, Sweden, Germany, Austria, Spain, Portugal, Italy, Greece, Turkey, Kuwait, Syria, Australia, and New Zealand. ApaTech Ltd. was founded in 2001 and is based in Elstree, the United Kingdom. It has operations in London, the United Kingdom; Foxborough, Massachusetts; and Berlin, Germany.

Corindus Vascular Robotics, Inc. specializes in the design, manufacture, and commercialization of robotic-assisted systems for interventional vascular procedures. Based in Waltham, Massachusetts, the company offers the CorPath system, which allows physicians to perform catheterization procedures from a radiation-shielded control console, enhancing precision and safety in coronary and peripheral interventions. The CorPath GRX system further enables the robotic-assisted control of guide catheters, guidewires, and balloon/stent devices. Corindus serves various markets, including vascular, coronary, neurointerventional, and structural heart fields, selling its products through a combination of direct sales and partnerships. Founded in 2002, Corindus is a subsidiary of Siemens Medical Solutions USA, Inc. as of late 2019.

HeartFlow is a medical technology company that provides new methods of diagnosis and treatment of cardiovascular disease. It offers HeartFlow Analysis, a non-invasive solution available in the United States, Europe, and Japan that helps a physician evaluate whether a patient has significant coronary artery disease based on anatomy and physiology. The company was started in 2007 and is based in Redwood City, California.