Lineus Medical specializes in developing medical devices aimed at preventing intravenous (IV) dislodgement and related mechanical complications. The company's flagship product, the SafeBreak Vascular device, incorporates patented break-away technology that facilitates a separation in the IV tubing when excessive tension is applied. This innovation is designed to enhance patient safety during IV therapy, helping to minimize the risk of dislodgement, blood loss, and potential infections. By focusing on the integration of this technology with various medical tubing, Lineus Medical aims to improve the overall quality of care for patients undergoing IV treatment.
SweetBio, Inc. is a medical device company based in Memphis, Tennessee, that focuses on the research, development, and manufacturing of innovative wound care solutions. Established in 2015, the company specializes in creating membranes that utilize medical-grade Manuka honey to enhance healing and reduce complications associated with various wounds, including surgical and diabetic ulcers. SweetBio’s flagship product, Apis, is a patented wound care patch that incorporates Manuka honey at a molecular level with gelatin and nanoparticles, resulting in a solid and long-lasting application that effectively manages exudate and maintains a moist wound environment. This product received FDA clearance in May 2019. SweetBio has participated in prominent accelerator programs and has gained recognition through media features, demonstrating its commitment to advancing wound care treatments.
Cast21 specializes in developing innovative orthopedic medical products, focusing on a lightweight, waterproof, and breathable cast designed for fracture and joint care. Their unique lattice-structure design addresses several limitations of traditional casts, providing comfort and convenience for patients. The cast's breathable material allows for skin care, enabling wearers to wash and scratch the skin beneath the cast while promoting healing. Additionally, Cast21's design incorporates the potential for electronic therapies, which can further reduce healing time. Overall, the company's products aim to enhance the recovery experience for patients by combining functionality with user comfort.
Spine Wave, Inc. manufactures and markets medical equipment for the treatment of spinal disorders. It offers expandable PEEK spacers and expandable interbody devices for posterior surgery; pivoting spacer systems; lateral spacer systems, XDL expandable devices, and lateral access systems for lateral stabilization; Leva PX, an expandable interbody device for the treatment of spinal disorders; GraftMag Graft Delivery System to deliver large amounts of bone graft; and fixation products, such as spine systems for treating degeneration, deformity, tumor, and trauma of the thoracolumbar spine, as well as adjacent level systems. The company also offers anterior cervical plate systems that provide stabilization as an adjunct to spinal fusion from C2-C7 through anterior screw fixation; and cervical spacer systems to treat degenerative disc disease from C2-T1. It offers its products through distributors. Spine Wave, Inc. was founded in 2001 and is based in Shelton, Connecticut.
Lineus Medical specializes in developing medical devices aimed at preventing intravenous (IV) dislodgement and related mechanical complications. The company's flagship product, the SafeBreak Vascular device, incorporates patented break-away technology that facilitates a separation in the IV tubing when excessive tension is applied. This innovation is designed to enhance patient safety during IV therapy, helping to minimize the risk of dislodgement, blood loss, and potential infections. By focusing on the integration of this technology with various medical tubing, Lineus Medical aims to improve the overall quality of care for patients undergoing IV treatment.
SweetBio, Inc. is a medical device company based in Memphis, Tennessee, that focuses on the research, development, and manufacturing of innovative wound care solutions. Established in 2015, the company specializes in creating membranes that utilize medical-grade Manuka honey to enhance healing and reduce complications associated with various wounds, including surgical and diabetic ulcers. SweetBio’s flagship product, Apis, is a patented wound care patch that incorporates Manuka honey at a molecular level with gelatin and nanoparticles, resulting in a solid and long-lasting application that effectively manages exudate and maintains a moist wound environment. This product received FDA clearance in May 2019. SweetBio has participated in prominent accelerator programs and has gained recognition through media features, demonstrating its commitment to advancing wound care treatments.
Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.
Restore Medical Solutions, Inc. is a medical device company based in Memphis, Tennessee, founded in 2012. The company specializes in manufacturing modular sterilization tray systems designed for use in hospitals and surgery centers. These systems aim to reduce the risk of surgical site infections by minimizing contamination from medical instruments. By enhancing efficiency and safety in healthcare settings, Restore Medical Solutions helps surgical departments improve the quality of care while also lowering costs. The innovative design of its products contributes to better operational productivity and supports the overall goal of delivering high-standard healthcare.
Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.
Better Walk Inc. is a company based in Atlanta, Georgia, that specializes in the design and development of innovative crutches. Established in 2013, Better Walk aims to enhance the user experience by alleviating pressure on the underarm area and minimizing direct force on the wrist, addressing common issues associated with traditional crutches. The company emerged from the idea that even longstanding technologies need modernization, a philosophy that has shaped its culture and growth. Better Walk gained initial support through the Zero To 510 accelerator program in Memphis, where it secured early venture funding. After relocating to Atlanta in late 2014, the company has been focused on finalizing the Better Walk crutch for production and is preparing for a product launch.
International Coding Technologies, Inc. is an inventory control and tracking technology company based in Lynnfield, Massachusetts. Founded in 2006, the firm specializes in developing and implementing radio frequency identification (RFID) and barcode solutions tailored for the construction industry. Its product offerings include Cast-A-Code and Steel-Code, which integrate RFID and barcode technology to be used in concrete and steel structures, and TrackCon, a GPS-enhanced system that aids in managing inventory and quality control for concrete and steel fabricators. Additionally, the company provides CodeGuard, a rugged RFID tag designed for asset tracking in various industries, along with GPS-enabled handheld scanners and wireless access points for operational support. International Coding Technologies also offers custom RFID solutions and consulting services to address the specific needs of its clients.
First launch of Idencia was in Q1 2014
EndoInSight specializes in developing a disposable insufflation system aimed at alleviating the pain and discomfort associated with colonoscopy procedures used for colorectal cancer screening. The company utilizes carbon dioxide for colon inflation, a method that significantly reduces post-procedural discomfort compared to traditional air insufflation. Despite the known advantages of using CO2, its adoption in clinical settings has been limited due to low awareness and the high costs of existing insufflation systems. By offering a cost-effective solution, EndoInSight seeks to enhance patient comfort and improve overall outcomes in colorectal cancer treatment.
CrossRoads Extremity Systems, LLC is a medical device company based in Memphis, Tennessee, that specializes in the design, manufacture, and marketing of implant systems specifically for foot and ankle surgeries. Founded in 2014, the company offers a range of products, including the MotoBAND CP Plating System for midfoot and forefoot procedures, STRoPP implant kits, and the MotoCLIP, which aids in bone healing through innovative fixation techniques. Additionally, CrossRoads provides implants like the CrossTIE series for hammertoe correction and revision cases, as well as Allograft wedges and DBM putties. Their DynaFORCE hybrid fixation system enhances surgical flexibility and dynamic compression. The company also emphasizes sustainability through its EcoSMART instrument recovery service, which addresses waste in surgical environments. Products are distributed across the United States, aiming to improve surgical outcomes and operational efficiency in healthcare settings.
Zyga Technology, Inc. is a medical device company focused on the research, design, development, and commercialization of minimally invasive solutions for lumbar spine conditions. The company offers the SImmetry Sacroiliac Joint Fusion System, which addresses various issues such as sacroiliac joint disruptions and degenerative sacroiliitis. Additionally, Zyga is developing the Glyder Facet Restoration System, an investigational device aimed at treating chronic facetogenic pain. Founded in 2008 and based in Minnetonka, Minnesota, Zyga Technology combines a skilled team of engineers, marketing professionals, and management with extensive experience in the spine industry. As of December 31, 2017, Zyga operates as a subsidiary of RTI Surgical, Inc.
EcoSurg is a developer of environmentally-friendly surgical supplies aimed at minimizing the carbon footprint in surgical settings. The company’s primary product, the EcoSurg line of patient positioners, consists of disposable foam shapes designed for use in over 20 million surgical procedures annually in the United States. These positioners help ensure patient safety, comfort, and proper access to surgical sites. Traditional disposable positioners are made from petroleum-based materials, which pose environmental hazards and lead to increased disposal costs. EcoSurg's innovative approach seeks to address these concerns by providing sustainable alternatives that reduce environmental impact while maintaining the necessary functionality for surgical procedures.
Blood Monitoring Solutions, Inc. is dedicated to advancing blood transfusion safety by providing innovative monitoring systems designed to prevent blood wastage. Based in Memphis, Tennessee, the company has developed a smart blood transport system that allows blood banks to continuously monitor the temperature and condition of each blood unit. This proactive, data-driven approach not only enhances patient safety but also helps reduce costs for hospitals globally. By ensuring that blood is stored within the appropriate temperature range, Blood Monitoring Solutions enables healthcare facilities to preserve blood for extended periods, thereby improving the efficiency of blood utilization and minimizing waste.
Compression Kinetics, Inc. is a Memphis-based company specializing in the design and development of innovative medical devices, particularly dynamic compression sleeves. These sleeves utilize shape memory alloy technology to generate pressure waves that enhance circulation, reduce peripheral edema, and help prevent blood clots. By translating clinically proven compression therapy into a sleek and mobile format, Compression Kinetics is positioned to make a significant impact in the $11 billion athletic compression apparel market. The company's products aim to improve recovery times and athletic performance for users, making advanced compression therapy accessible to both amateur and professional athletes.
Innometrix, Inc. is a Memphis-based company focused on developing advanced technology to enhance the diagnosis and treatment of female pelvic floor disorders. These conditions are prevalent, affecting approximately 50% of women who have given birth, and they contribute to significant healthcare costs. Innometrix aims to translate biomechanics into clinical solutions by producing a biomechanical snapshot of the female pelvic floor, providing physicians with vital data prior to surgical procedures. The company addresses the limitations of current treatment methods, which often rely on subjective judgment and have high complication rates. By creating innovative device solutions, Innometrix seeks to improve treatment outcomes and increase patient satisfaction in a field that requires significant advancements.
CamPlex, founded in 2012 and headquartered in Germantown, Tennessee, operates in the healthcare sector as a manufacturer of high-quality fiber optic solutions. The company specializes in fiber optic-based camera adapter systems and broadcast-grade interface gear. These products are designed to enhance performance and extend signal transmission capabilities, thereby facilitating easier and more efficient signal delivery for broadcast professionals. By providing these innovative solutions, CamPlex helps reduce operating costs by minimizing the need for additional components and expensive replacements.
Tidal Wave Technology
Seed Round in 2014
Tidal Wave Technology manufactures a device to achieve a circumferential ablation of the nerves that surround the renal artery. It allows for renal denervation without placing any ablative elements within the renal artery. The company was founded in 2011 and is based in Memphis, Tennessee.
Hubble Telemedical focuses on the early detection of systemic and debilitating diseases that can be identified through retinal examination. Their Telemedical Retinal Image Analysis and Diagnosis (TRIAD) technology offers real-time diagnosis of diabetic retinopathy and other retinal conditions, utilizing commonly available retina cameras. This innovative approach addresses the issue of many at-risk individuals not receiving necessary annual retinal exams due to accessibility and convenience challenges. By partnering with healthcare providers, insurance companies, and employers, Hubble Telemedical aims to make retinal screening more accessible, ultimately improving health outcomes and reducing healthcare costs. Their services are fully compliant with HIPAA regulations, ensuring security and ease of use. Clinical studies support the effectiveness of their technology in increasing annual screening compliance, thereby enhancing patient care and facilitating timely treatment for various diseases.
Restore Medical Solutions, Inc. is a medical device company based in Memphis, Tennessee, founded in 2012. The company specializes in manufacturing modular sterilization tray systems designed for use in hospitals and surgery centers. These systems aim to reduce the risk of surgical site infections by minimizing contamination from medical instruments. By enhancing efficiency and safety in healthcare settings, Restore Medical Solutions helps surgical departments improve the quality of care while also lowering costs. The innovative design of its products contributes to better operational productivity and supports the overall goal of delivering high-standard healthcare.
Mobilizer Inc. has developed an innovative six-wheeled holster designed to facilitate medical ambulation for critical care patients. Modeled after a wheeled walker, this holster features shelves and attachments that allow healthcare providers to easily transport necessary medical equipment, thereby enhancing patient well-being and improving operational efficiency within hospitals. The company emerged from the ZeroTo510 medical device startup accelerator, focusing on solutions that streamline the process of moving patients while ensuring that essential tools are readily accessible.
Hapten Sciences, Inc. operates as a biopharmaceutical company. It identifies and develops early-stage products, such as PDC-APB that acts as a vaccine to prevent contact dermatitis caused by exposure to urushiol oil in poison ivy, poison oak, or poison sumac plants. The company was incorporated in 2010 and is based in Memphis, Tennessee.
iScreen Vision, Inc. is a Memphis-based medical device company that specializes in developing vision screening equipment for children. The company employs a patented photoscreening technology, which allows for the rapid and effective detection of various common vision problems in infants, preschool, and school-age children. This non-invasive method screens for issues such as refractive errors, eye alignment problems, and other conditions that could lead to serious vision impairments if not identified early. iScreen Vision's digital photoscreening requires no response from the patient, making it particularly suitable for non-verbal and developmentally challenged children. The company also integrates cloud-based technology to facilitate the storage and analysis of screening images, enabling seamless integration with physicians' electronic medical records. Founded in 2009, iScreen Vision aims to improve early diagnosis and treatment options to prevent irreversible vision loss in children.
Better Walk Inc. is a company based in Atlanta, Georgia, that specializes in the design and development of innovative crutches. Established in 2013, Better Walk aims to enhance the user experience by alleviating pressure on the underarm area and minimizing direct force on the wrist, addressing common issues associated with traditional crutches. The company emerged from the idea that even longstanding technologies need modernization, a philosophy that has shaped its culture and growth. Better Walk gained initial support through the Zero To 510 accelerator program in Memphis, where it secured early venture funding. After relocating to Atlanta in late 2014, the company has been focused on finalizing the Better Walk crutch for production and is preparing for a product launch.
Mobilizer Inc. has developed an innovative six-wheeled holster designed to facilitate medical ambulation for critical care patients. Modeled after a wheeled walker, this holster features shelves and attachments that allow healthcare providers to easily transport necessary medical equipment, thereby enhancing patient well-being and improving operational efficiency within hospitals. The company emerged from the ZeroTo510 medical device startup accelerator, focusing on solutions that streamline the process of moving patients while ensuring that essential tools are readily accessible.
Bell BioNanonostics Corp. focuses on monitoring of bacterial infection. Bell BioNanonostics Corp. is based in the United States.
View Medical, Inc. specializes in surgical lighting solutions aimed at enhancing visibility during deep cavity surgeries. Founded in 2013 and based in Memphis, Tennessee, the company has developed the SurgiLight lighting system, which connects to existing overhead surgical lights. This innovative system features a long, flexible cable that allows surgeons to direct bright, localized LED illumination onto the surgical site from various angles. By addressing the common issue of insufficient lighting in operating rooms, View Medical's product aims to reduce the risks associated with surgical errors, which cost the U.S. healthcare system approximately $1.5 billion annually. The SurgiLight offers a practical alternative to traditional surgical headlights, helping to improve operating conditions and ultimately enhance patient outcomes.
Focal Point Pharmaceuticals
Seed Round in 2013
Focal Point Pharmaceuticals is a healthcare company focused on pharmaceutical businesses. It was incorporated in 2013 and is based in Memphis, Tennessee, United States.
iScreen Vision, Inc. is a Memphis-based medical device company that specializes in developing vision screening equipment for children. The company employs a patented photoscreening technology, which allows for the rapid and effective detection of various common vision problems in infants, preschool, and school-age children. This non-invasive method screens for issues such as refractive errors, eye alignment problems, and other conditions that could lead to serious vision impairments if not identified early. iScreen Vision's digital photoscreening requires no response from the patient, making it particularly suitable for non-verbal and developmentally challenged children. The company also integrates cloud-based technology to facilitate the storage and analysis of screening images, enabling seamless integration with physicians' electronic medical records. Founded in 2009, iScreen Vision aims to improve early diagnosis and treatment options to prevent irreversible vision loss in children.
EcoSurg is a developer of environmentally-friendly surgical supplies aimed at minimizing the carbon footprint in surgical settings. The company’s primary product, the EcoSurg line of patient positioners, consists of disposable foam shapes designed for use in over 20 million surgical procedures annually in the United States. These positioners help ensure patient safety, comfort, and proper access to surgical sites. Traditional disposable positioners are made from petroleum-based materials, which pose environmental hazards and lead to increased disposal costs. EcoSurg's innovative approach seeks to address these concerns by providing sustainable alternatives that reduce environmental impact while maintaining the necessary functionality for surgical procedures.
Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.
Cuff-Protect
Seed Round in 2013
Cuff-Mate skin barriers offer healthcare professionals a cost-effective way to protect their patients, themselves and equipment when taking vital signs.
Hapten Sciences, Inc. operates as a biopharmaceutical company. It identifies and develops early-stage products, such as PDC-APB that acts as a vaccine to prevent contact dermatitis caused by exposure to urushiol oil in poison ivy, poison oak, or poison sumac plants. The company was incorporated in 2010 and is based in Memphis, Tennessee.
Hubble Telemedical focuses on the early detection of systemic and debilitating diseases that can be identified through retinal examination. Their Telemedical Retinal Image Analysis and Diagnosis (TRIAD) technology offers real-time diagnosis of diabetic retinopathy and other retinal conditions, utilizing commonly available retina cameras. This innovative approach addresses the issue of many at-risk individuals not receiving necessary annual retinal exams due to accessibility and convenience challenges. By partnering with healthcare providers, insurance companies, and employers, Hubble Telemedical aims to make retinal screening more accessible, ultimately improving health outcomes and reducing healthcare costs. Their services are fully compliant with HIPAA regulations, ensuring security and ease of use. Clinical studies support the effectiveness of their technology in increasing annual screening compliance, thereby enhancing patient care and facilitating timely treatment for various diseases.
SurgiLight
Seed Round in 2013
SurgiLight offers a surgical lighting system that provides surgeons with a practical illumination device, enabling them to focus on target areas.
Health & Bliss Inc. is a medical device company based in Memphis, Tennessee, specializing in the design, patenting, and sale of medical products and diagnostic tests. The company has developed Strep Test Anywhere, an innovative point-of-care device that enables testing for multiple infections, including strep throat, influenza A/B, chlamydia, gonorrhea, hepatitis B/C, and several other illnesses. By providing a means to obtain accurate test results without the need for a doctor visit, Health & Bliss aims to address significant barriers to effective healthcare, specifically time and cost. Their technology is designed to improve patient access to diagnostic services while benefiting healthcare providers and payers alike.
Mobilizer Inc. has developed an innovative six-wheeled holster designed to facilitate medical ambulation for critical care patients. Modeled after a wheeled walker, this holster features shelves and attachments that allow healthcare providers to easily transport necessary medical equipment, thereby enhancing patient well-being and improving operational efficiency within hospitals. The company emerged from the ZeroTo510 medical device startup accelerator, focusing on solutions that streamline the process of moving patients while ensuring that essential tools are readily accessible.
Better Walk Inc. is a company based in Atlanta, Georgia, that specializes in the design and development of innovative crutches. Established in 2013, Better Walk aims to enhance the user experience by alleviating pressure on the underarm area and minimizing direct force on the wrist, addressing common issues associated with traditional crutches. The company emerged from the idea that even longstanding technologies need modernization, a philosophy that has shaped its culture and growth. Better Walk gained initial support through the Zero To 510 accelerator program in Memphis, where it secured early venture funding. After relocating to Atlanta in late 2014, the company has been focused on finalizing the Better Walk crutch for production and is preparing for a product launch.
Although it is still relatively new, AIS, having a relationship with other biology-inspired computing models, and computational biology.
Spinal Restoration, Inc. focuses on developing innovative therapies for chronic low back pain, emphasizing early intervention and minimally invasive techniques. The company's primary product is the Biostat System, which includes a proprietary resorbable biologic compound and a specialized delivery system designed to treat discogenic low back pain caused by internal disc disruptions. This system features the BIOSTAT BIOLOGX Fibrin Sealant, a resorbable tissue sealant, and the Biostat Delivery Device, which facilitates the targeted application of the biologic to the intervertebral disc. Founded in 2004 and headquartered in New York, Spinal Restoration aims to address the needs of a significant population, with an estimated four million adults affected by chronic low back pain each year.
Tidal Wave Technology
Seed Round in 2013
Tidal Wave Technology manufactures a device to achieve a circumferential ablation of the nerves that surround the renal artery. It allows for renal denervation without placing any ablative elements within the renal artery. The company was founded in 2011 and is based in Memphis, Tennessee.
AxioMed LLC, founded in 2001 and located in Malden, Massachusetts, specializes in designing and developing disc replacement devices aimed at alleviating neck pain and restoring normal spinal functions for patients suffering from degenerative disc disease. The company, previously known as AxioMed Spine Corporation until its name change in 2014, has focused on advancing the standard of care beyond traditional fusion and first-generation artificial discs. AxioMed has developed the Freedom® Lumbar Disc and is currently working on a project for cervical spine applications, having initiated clinical trials for its products. The management team, led by CEO Patrick McBrayer and COO James Kuras, consists of experienced professionals with significant expertise in spinal implants. Additionally, AxioMed collaborates with a Medical Advisory Panel of surgeons from prominent spine centers and universities to enhance its product development and regulatory strategies.
Hubble Telemedical focuses on the early detection of systemic and debilitating diseases that can be identified through retinal examination. Their Telemedical Retinal Image Analysis and Diagnosis (TRIAD) technology offers real-time diagnosis of diabetic retinopathy and other retinal conditions, utilizing commonly available retina cameras. This innovative approach addresses the issue of many at-risk individuals not receiving necessary annual retinal exams due to accessibility and convenience challenges. By partnering with healthcare providers, insurance companies, and employers, Hubble Telemedical aims to make retinal screening more accessible, ultimately improving health outcomes and reducing healthcare costs. Their services are fully compliant with HIPAA regulations, ensuring security and ease of use. Clinical studies support the effectiveness of their technology in increasing annual screening compliance, thereby enhancing patient care and facilitating timely treatment for various diseases.
Spinal Restoration, Inc. focuses on developing innovative therapies for chronic low back pain, emphasizing early intervention and minimally invasive techniques. The company's primary product is the Biostat System, which includes a proprietary resorbable biologic compound and a specialized delivery system designed to treat discogenic low back pain caused by internal disc disruptions. This system features the BIOSTAT BIOLOGX Fibrin Sealant, a resorbable tissue sealant, and the Biostat Delivery Device, which facilitates the targeted application of the biologic to the intervertebral disc. Founded in 2004 and headquartered in New York, Spinal Restoration aims to address the needs of a significant population, with an estimated four million adults affected by chronic low back pain each year.
EcoSurg is a developer of environmentally-friendly surgical supplies aimed at minimizing the carbon footprint in surgical settings. The company’s primary product, the EcoSurg line of patient positioners, consists of disposable foam shapes designed for use in over 20 million surgical procedures annually in the United States. These positioners help ensure patient safety, comfort, and proper access to surgical sites. Traditional disposable positioners are made from petroleum-based materials, which pose environmental hazards and lead to increased disposal costs. EcoSurg's innovative approach seeks to address these concerns by providing sustainable alternatives that reduce environmental impact while maintaining the necessary functionality for surgical procedures.
Tidal Wave Technology
Seed Round in 2012
Tidal Wave Technology manufactures a device to achieve a circumferential ablation of the nerves that surround the renal artery. It allows for renal denervation without placing any ablative elements within the renal artery. The company was founded in 2011 and is based in Memphis, Tennessee.
Nanophthalmics has developed and is licensing a patent-pending platform technology for microfabricated instruments that engage tissue in entirely new ways. Their focus is on employing novel surgical devices, techniques, and materials to improve current treatment outcomes for ophthalmic and other microsurgical diseases. Their first commercial device is a disposable, 510(k) exempt, corneal micro-punch that enhances healing of abrasions, recurrent erosions, and other corneal diseases by modifying tissue attachments at a cellular level.
Urova Medical was founded in Memphis, TN with the goal of providing a novel solution to cure stress urinary incontinence safely, effectively, and conveniently.
Urova Medical’s technology was developed by an undergraduate team of talented biomedical engineers at Johns Hopkins University. The implant was designed extensively under the mentorship of physicians from the Johns Hopkins Hospital, the number one urological center in the US. Urova Medical has been part of the Zeroto510 Accelerator program sponsored by Innova Fund and MB Ventures, both venture capital firms based in Memphis
Bell BioNanonostics Corp. focuses on monitoring of bacterial infection. Bell BioNanonostics Corp. is based in the United States.
EcoSurg is a developer of environmentally-friendly surgical supplies aimed at minimizing the carbon footprint in surgical settings. The company’s primary product, the EcoSurg line of patient positioners, consists of disposable foam shapes designed for use in over 20 million surgical procedures annually in the United States. These positioners help ensure patient safety, comfort, and proper access to surgical sites. Traditional disposable positioners are made from petroleum-based materials, which pose environmental hazards and lead to increased disposal costs. EcoSurg's innovative approach seeks to address these concerns by providing sustainable alternatives that reduce environmental impact while maintaining the necessary functionality for surgical procedures.
Hapten Sciences, Inc. operates as a biopharmaceutical company. It identifies and develops early-stage products, such as PDC-APB that acts as a vaccine to prevent contact dermatitis caused by exposure to urushiol oil in poison ivy, poison oak, or poison sumac plants. The company was incorporated in 2010 and is based in Memphis, Tennessee.
S2 Interactive, Inc. is a Delaware C corp. founded by Larry Foster, R.N., in September, 2011. After working as a surgical nurse and spending 26 years in leadership roles within sales, marketing and professional education in the orthopedic & spine industry, Larry was convinced there was an opportunity to teach hospital staff to learn and manage surgical instruments more efficiently and safely. Larry spent five years working with technology experts realizing with the current trends in healthcare there was a clear need to increase hospital staff productivity/efficiency while driving cost savings. Larry’s vision combined with the introduction of user-friendly “hand held” technology platforms (tablets) enabled S2 Interactive to develop Virtual Back Table and Tray Touch software platforms. In September, 2011 additional funding was provided by 2 Memphis based venture capital organizations, Innova & MB Ventures. They are proud to be working with market leading companies in Medical Devices and many of the nation’s most prominent hospitals. Their technology has been used by over 1,000 different users in a variety of surgical specialties including cardiology, orthopedics, spine , general surgery and trauma.
Urova Medical was founded in Memphis, TN with the goal of providing a novel solution to cure stress urinary incontinence safely, effectively, and conveniently.
Urova Medical’s technology was developed by an undergraduate team of talented biomedical engineers at Johns Hopkins University. The implant was designed extensively under the mentorship of physicians from the Johns Hopkins Hospital, the number one urological center in the US. Urova Medical has been part of the Zeroto510 Accelerator program sponsored by Innova Fund and MB Ventures, both venture capital firms based in Memphis
Hubble Telemedical focuses on the early detection of systemic and debilitating diseases that can be identified through retinal examination. Their Telemedical Retinal Image Analysis and Diagnosis (TRIAD) technology offers real-time diagnosis of diabetic retinopathy and other retinal conditions, utilizing commonly available retina cameras. This innovative approach addresses the issue of many at-risk individuals not receiving necessary annual retinal exams due to accessibility and convenience challenges. By partnering with healthcare providers, insurance companies, and employers, Hubble Telemedical aims to make retinal screening more accessible, ultimately improving health outcomes and reducing healthcare costs. Their services are fully compliant with HIPAA regulations, ensuring security and ease of use. Clinical studies support the effectiveness of their technology in increasing annual screening compliance, thereby enhancing patient care and facilitating timely treatment for various diseases.
HandMinder is a developer of a portable hand rehabilitation device designed to aid stroke survivors in regaining hand function. With approximately 7 million stroke survivors in the United States and 795,000 new or recurrent cases each year, many face significant hand dysfunction, which affects their quality of life. Current rehabilitation methods primarily focus on muscle rehabilitation, often leaving patients in a passive role, and can be both expensive and inconvenient. Recognizing the need for more effective solutions, HandMinder utilizes patent-pending vibration-guided brain engagement technology that enhances neural connections between the hand and brain. Research indicates that this active engagement can double the amount of hand movement and improve its quality by 2.5 times compared to traditional treatments. The HandMinder device is designed to be affordable and convenient, making it suitable for use in both clinical settings and at home, ultimately aiming to improve rehabilitation outcomes for stroke victims.
Restore Medical Solutions, Inc. is a medical device company based in Memphis, Tennessee, founded in 2012. The company specializes in manufacturing modular sterilization tray systems designed for use in hospitals and surgery centers. These systems aim to reduce the risk of surgical site infections by minimizing contamination from medical instruments. By enhancing efficiency and safety in healthcare settings, Restore Medical Solutions helps surgical departments improve the quality of care while also lowering costs. The innovative design of its products contributes to better operational productivity and supports the overall goal of delivering high-standard healthcare.
Zyga Technology, Inc. is a medical device company focused on the research, design, development, and commercialization of minimally invasive solutions for lumbar spine conditions. The company offers the SImmetry Sacroiliac Joint Fusion System, which addresses various issues such as sacroiliac joint disruptions and degenerative sacroiliitis. Additionally, Zyga is developing the Glyder Facet Restoration System, an investigational device aimed at treating chronic facetogenic pain. Founded in 2008 and based in Minnetonka, Minnesota, Zyga Technology combines a skilled team of engineers, marketing professionals, and management with extensive experience in the spine industry. As of December 31, 2017, Zyga operates as a subsidiary of RTI Surgical, Inc.
Tidal Wave Technology
Seed Round in 2012
Tidal Wave Technology manufactures a device to achieve a circumferential ablation of the nerves that surround the renal artery. It allows for renal denervation without placing any ablative elements within the renal artery. The company was founded in 2011 and is based in Memphis, Tennessee.
Veracity Medical Solutions, Inc. is a contract manufacturing company based in Collierville, Tennessee, specializing in the medical device industry. Founded in 2007, the company provides comprehensive manufacturing services, ranging from raw materials to finished products, including laser marking and packaging. Veracity Medical offers additional value-added services such as design, development, prototyping, and customization. The company employs a quality analysis system that ensures adherence to strict specifications, enabling clients to efficiently develop surgical instrumentation and implants. As of 2018, Veracity Medical operates as a subsidiary of Arcamed, LLC.
Cayenne Medical, Inc. is a medical device company specializing in soft tissue reconstruction solutions for the knee, shoulder, and extremities. Founded in 2005 and based in Scottsdale, Arizona, the company designs and markets a range of products aimed at improving surgical outcomes in sports medicine. Its offerings include the AperFix System, which facilitates anterior cruciate ligament (ACL) reconstruction using soft tissue grafts, as well as the AperFix II Cannulated Tibial Device and the AperFix Femoral Implant for anatomical soft tissue fixation. Cayenne Medical also provides the CrossFix II System for meniscal repair, the iFix for bone-tendon fixation, and the Cayenne Mirror Partial Knee System for early-stage knee arthritis treatment. In the shoulder category, the Quattro System addresses rotator cuff and labral repairs. Cayenne Medical operates as a subsidiary of Zimmer Biomet Holdings, enhancing its capacity to deliver innovative medical solutions.
Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.
Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.
AxioMed LLC, founded in 2001 and located in Malden, Massachusetts, specializes in designing and developing disc replacement devices aimed at alleviating neck pain and restoring normal spinal functions for patients suffering from degenerative disc disease. The company, previously known as AxioMed Spine Corporation until its name change in 2014, has focused on advancing the standard of care beyond traditional fusion and first-generation artificial discs. AxioMed has developed the Freedom® Lumbar Disc and is currently working on a project for cervical spine applications, having initiated clinical trials for its products. The management team, led by CEO Patrick McBrayer and COO James Kuras, consists of experienced professionals with significant expertise in spinal implants. Additionally, AxioMed collaborates with a Medical Advisory Panel of surgeons from prominent spine centers and universities to enhance its product development and regulatory strategies.
Anulex Technologies focus on developing proprietary medical technology to repair and seal the soft tissue of the spine (anulus) for patients undergoing a surgical procedure to remove a herniated disc (discectomy).
CaloSyn Pharma, Inc. is a biopharmaceutical company focused on developing intra-articular therapeutics specifically for osteoarthritis (OA), a condition affecting over 27 million people in the United States and more than 100 million globally. Founded in 2007 and headquartered in Boston, Massachusetts, with additional offices in Shreveport, Louisiana, and Atlanta, Georgia, the company is advancing a novel approach to OA treatment through the use of calcium channel blockers, drugs traditionally employed in heart and vascular disease management. By leveraging new insights into the mechanisms of these drugs and the processes underlying joint damage and pain in osteoarthritis, CaloSyn Pharma aims to reformulate and repurpose these medications for direct injection into affected joints. The company is currently conducting a Phase II clinical trial in the United States to evaluate the efficacy of its therapeutic approach.
Anulex Technologies focus on developing proprietary medical technology to repair and seal the soft tissue of the spine (anulus) for patients undergoing a surgical procedure to remove a herniated disc (discectomy).
Visioneering Technologies, Inc., based in Alpharetta, Georgia, is a medical device company specializing in the design, manufacture, sale, and distribution of innovative contact lenses. The company’s flagship product, the NaturalVue multifocal contact lens, addresses the vision needs of adults with presbyopia and children with myopia, offering significant improvements in optical design and patient outcomes. Founded in 2008 by Dr. Richard A. Griffin, Visioneering holds multiple patents that focus on enhancing vision correction solutions. The company operates in various international markets, including the United States, Australia, New Zealand, Europe, Hong Kong, and Singapore. Visioneering aims to improve eye care experiences for both practitioners and patients by leveraging advanced technology and design.
BrainsGate, Ltd., a medical device company, develops therapies for patients suffering from central nervous system (CNS) diseases. It offers a technology platform that involves electrical stimulation of the spheno-palatine ganglion (SPG), a nervous center known to increase cerebral blood flow. The company develops an ischemic stroke system that is based on an implantable electrode and is designed to deliver electrical stimulation to the spheno-palatine ganglion (SPG). Its system augments cerebral blood flow by using an external system temporarily attached to the patient’s cheek. BrainsGate, Ltd. was founded in 2000 and is based in Caesarea, Israel.
Protein Discovery, Inc. is a life sciences company specializing in the development and commercialization of innovative sample preparation technologies for protein and peptide analysis via mass spectrometry. The company offers several key products, including the Gelfree 8100 fractionation system, which separates complex protein mixtures into liquid-phase molecular weight fractions, and the Passport 1200 sample preparation system, designed to enrich low molecular weight proteins and peptides while eliminating matrix interferences, facilitating high-throughput quantification. Additionally, Protein Discovery provides the PPS Silent Surfactant, a reagent that solubilizes membrane proteins and reduces detergent interference. The UPX universal protein extraction kit is also available for detergent extraction of proteins from cells and tissues. Catering to life science researchers and drug development scientists, Protein Discovery markets its products both through Agilent Technologies and online, reaching a global audience. Founded in 2001 in Knoxville, Tennessee, the company was originally named Qgenics Biosciences, Inc. before rebranding to its current name in 2004.
Cayenne Medical, Inc. is a medical device company specializing in soft tissue reconstruction solutions for the knee, shoulder, and extremities. Founded in 2005 and based in Scottsdale, Arizona, the company designs and markets a range of products aimed at improving surgical outcomes in sports medicine. Its offerings include the AperFix System, which facilitates anterior cruciate ligament (ACL) reconstruction using soft tissue grafts, as well as the AperFix II Cannulated Tibial Device and the AperFix Femoral Implant for anatomical soft tissue fixation. Cayenne Medical also provides the CrossFix II System for meniscal repair, the iFix for bone-tendon fixation, and the Cayenne Mirror Partial Knee System for early-stage knee arthritis treatment. In the shoulder category, the Quattro System addresses rotator cuff and labral repairs. Cayenne Medical operates as a subsidiary of Zimmer Biomet Holdings, enhancing its capacity to deliver innovative medical solutions.
Spinal Restoration, Inc. focuses on developing innovative therapies for chronic low back pain, emphasizing early intervention and minimally invasive techniques. The company's primary product is the Biostat System, which includes a proprietary resorbable biologic compound and a specialized delivery system designed to treat discogenic low back pain caused by internal disc disruptions. This system features the BIOSTAT BIOLOGX Fibrin Sealant, a resorbable tissue sealant, and the Biostat Delivery Device, which facilitates the targeted application of the biologic to the intervertebral disc. Founded in 2004 and headquartered in New York, Spinal Restoration aims to address the needs of a significant population, with an estimated four million adults affected by chronic low back pain each year.
KFx Medical specializes in the development and manufacturing of innovative soft tissue fixation implants aimed at orthopedic sports medicine. The company provides a system designed for tissue fixation, offering products that can be directly placed into bones, both with and without sutures. These implants are utilized in various orthopedic surgical procedures, allowing surgeons to effectively reattach tissue in areas such as the shoulder, knee, foot, and ankle. By collaborating with leading orthopedic surgeons, KFx Medical focuses on advancing technology and delivering reliable surgical implants, ultimately aiming to enhance surgical outcomes for patients.
BioSET, Inc., founded in 2001 and based in Rockville, Maryland, specializes in the research and development of synthetic bioactive peptides for medical applications. The company focuses on creating proprietary therapeutic peptides and implantable devices designed to enhance bone and soft tissue repair, particularly in orthobiologics. Its flagship product, Amplex, is an implantable device that combines a peptide with a synthetic ceramic scaffold, serving as a surgical bone graft implant for various spinal and orthopedic surgeries, including lumbar degenerative disc disease and foot and ankle fusion procedures. Additionally, BioSET develops products for sports medicine and offers peptide signaling molecules along with diverse scaffold biomaterials to support musculoskeletal applications, including trauma and fracture repair. As of February 2015, BioSET operates as a subsidiary of Ferring Pharmaceuticals Inc.
Applied Spine Technologies is a company based in Wellesley, Massachusetts, specializing in the design and development of medical devices focused on spine stabilization. The firm offers innovative solutions, including the Stabilimax Dynamic Spine Stabilization System, which functions as a posterior dynamic stabilization device. This system is designed to support patients with injured or degenerated spines while preserving natural motion, distinguishing it from traditional stabilization methods that often restrict movement. Through its specialized products, Applied Spine Technologies aims to improve treatment outcomes for individuals with spinal conditions.
Cayenne Medical, Inc. is a medical device company specializing in soft tissue reconstruction solutions for the knee, shoulder, and extremities. Founded in 2005 and based in Scottsdale, Arizona, the company designs and markets a range of products aimed at improving surgical outcomes in sports medicine. Its offerings include the AperFix System, which facilitates anterior cruciate ligament (ACL) reconstruction using soft tissue grafts, as well as the AperFix II Cannulated Tibial Device and the AperFix Femoral Implant for anatomical soft tissue fixation. Cayenne Medical also provides the CrossFix II System for meniscal repair, the iFix for bone-tendon fixation, and the Cayenne Mirror Partial Knee System for early-stage knee arthritis treatment. In the shoulder category, the Quattro System addresses rotator cuff and labral repairs. Cayenne Medical operates as a subsidiary of Zimmer Biomet Holdings, enhancing its capacity to deliver innovative medical solutions.
Anulex Technologies focus on developing proprietary medical technology to repair and seal the soft tissue of the spine (anulus) for patients undergoing a surgical procedure to remove a herniated disc (discectomy).
Kereos, Inc. is a biopharmaceutical company based in Saint Louis, Missouri, specializing in the development of targeted molecular imaging agents and therapeutics aimed at detecting and treating cancer and cardiovascular diseases. Established in 1999, Kereos utilizes a nanoscale drug delivery technology that enhances the targeting and efficacy of various therapeutic compounds, including existing drugs, new candidates, and those that may be too toxic or fragile for conventional delivery methods. The company's product portfolio includes KER-1001, a cancer therapeutic that combines paclitaxel with a targeted nanodroplet, KER-1002, which integrates a natural anti-tumor agent, and KER-1003, known for its anti-angiogenic properties. Additionally, Kereos offers diagnostic solutions such as KER 0001, designed to detect angiogenesis. The company also collaborates with pharmaceutical and imaging firms to further develop its MRI agents and targeted chemotherapeutics for solid tumors and cardiovascular applications.
KFx Medical specializes in the development and manufacturing of innovative soft tissue fixation implants aimed at orthopedic sports medicine. The company provides a system designed for tissue fixation, offering products that can be directly placed into bones, both with and without sutures. These implants are utilized in various orthopedic surgical procedures, allowing surgeons to effectively reattach tissue in areas such as the shoulder, knee, foot, and ankle. By collaborating with leading orthopedic surgeons, KFx Medical focuses on advancing technology and delivering reliable surgical implants, ultimately aiming to enhance surgical outcomes for patients.
BrainsGate, Ltd., a medical device company, develops therapies for patients suffering from central nervous system (CNS) diseases. It offers a technology platform that involves electrical stimulation of the spheno-palatine ganglion (SPG), a nervous center known to increase cerebral blood flow. The company develops an ischemic stroke system that is based on an implantable electrode and is designed to deliver electrical stimulation to the spheno-palatine ganglion (SPG). Its system augments cerebral blood flow by using an external system temporarily attached to the patient’s cheek. BrainsGate, Ltd. was founded in 2000 and is based in Caesarea, Israel.
BioMimetic Therapeutics is a biotechnology company focused on developing biologically active drug-device combination products that stimulate the body's natural tissue regenerative processes. Founded in 1999 and headquartered in Franklin, Tennessee, the company offers a range of products targeting various orthopedic and sports medicine conditions. These include Augment Injectable and Augment Rotator Cuff, which are designed for applications such as foot and ankle fusions, wrist fracture healing, and rotator cuff tear surgical treatment. Additionally, the Augment Tendinopathy Injection addresses injuries related to tendon overuse. Through its innovative approaches, BioMimetic Therapeutics aims to improve healing outcomes for patients with skeletal and associated tissue injuries.
AxioMed LLC, founded in 2001 and located in Malden, Massachusetts, specializes in designing and developing disc replacement devices aimed at alleviating neck pain and restoring normal spinal functions for patients suffering from degenerative disc disease. The company, previously known as AxioMed Spine Corporation until its name change in 2014, has focused on advancing the standard of care beyond traditional fusion and first-generation artificial discs. AxioMed has developed the Freedom® Lumbar Disc and is currently working on a project for cervical spine applications, having initiated clinical trials for its products. The management team, led by CEO Patrick McBrayer and COO James Kuras, consists of experienced professionals with significant expertise in spinal implants. Additionally, AxioMed collaborates with a Medical Advisory Panel of surgeons from prominent spine centers and universities to enhance its product development and regulatory strategies.
BioMimetic Therapeutics is a biotechnology company focused on developing biologically active drug-device combination products that stimulate the body's natural tissue regenerative processes. Founded in 1999 and headquartered in Franklin, Tennessee, the company offers a range of products targeting various orthopedic and sports medicine conditions. These include Augment Injectable and Augment Rotator Cuff, which are designed for applications such as foot and ankle fusions, wrist fracture healing, and rotator cuff tear surgical treatment. Additionally, the Augment Tendinopathy Injection addresses injuries related to tendon overuse. Through its innovative approaches, BioMimetic Therapeutics aims to improve healing outcomes for patients with skeletal and associated tissue injuries.
BioSET, Inc., founded in 2001 and based in Rockville, Maryland, specializes in the research and development of synthetic bioactive peptides for medical applications. The company focuses on creating proprietary therapeutic peptides and implantable devices designed to enhance bone and soft tissue repair, particularly in orthobiologics. Its flagship product, Amplex, is an implantable device that combines a peptide with a synthetic ceramic scaffold, serving as a surgical bone graft implant for various spinal and orthopedic surgeries, including lumbar degenerative disc disease and foot and ankle fusion procedures. Additionally, BioSET develops products for sports medicine and offers peptide signaling molecules along with diverse scaffold biomaterials to support musculoskeletal applications, including trauma and fracture repair. As of February 2015, BioSET operates as a subsidiary of Ferring Pharmaceuticals Inc.
Alveolus specializes in non-vascular interventional stenting technology aimed at providing innovative solutions for pulmonary and gastrointestinal applications, as well as ancillary products. The company develops advanced stents that create artificial pathways and support structures for hollow organs that have become obstructed due to cancerous lesions or benign conditions. By offering these technologies, Alveolus enhances the capabilities of interventional pulmonologists, gastroenterologists, and radiologists, facilitating improved treatment options for patients facing these medical challenges.
Salient Surgical Technologies, Inc., established in 1999, is a privately held medical technology company that specializes in advanced energy devices for surgical procedures. Initially focusing on monopolar electrosurgical devices for liver cancer treatment, the company has since developed the AQUAMANTYS® System, which features bipolar electrosurgical technology. This system is designed to minimize surgical blood loss through its patented TRANSCOLLATION® technology, which enables the haemostatic sealing of soft tissue and bone. The AQUAMANTYS System is utilized in various surgeries, including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's products are distributed in the United States, Europe, and Asia, benefiting hospitals, healthcare providers, and patients by enhancing clinical outcomes and reducing costs. To date, over 500,000 patients have undergone treatment using TRANSCOLLATION technology.
GTx, Inc. is a company of pioneering and driven individuals who are delivering better medicines with new science through established pathways.
BioMimetic Therapeutics is a biotechnology company focused on developing biologically active drug-device combination products that stimulate the body's natural tissue regenerative processes. Founded in 1999 and headquartered in Franklin, Tennessee, the company offers a range of products targeting various orthopedic and sports medicine conditions. These include Augment Injectable and Augment Rotator Cuff, which are designed for applications such as foot and ankle fusions, wrist fracture healing, and rotator cuff tear surgical treatment. Additionally, the Augment Tendinopathy Injection addresses injuries related to tendon overuse. Through its innovative approaches, BioMimetic Therapeutics aims to improve healing outcomes for patients with skeletal and associated tissue injuries.
TriVirix International is a U.S.-based company that manufactures and designs electro-mechanical, medical, diagnostic, analytical, and life-science devices. The company provides its clients with ribo printers, point-of-care blood testing analyzers, volumetric infusion pumps, and vital sign or conscious sedation monitors. TriVirix International is headquartered in Milaca, Minnesota.