Innova Memphis is a Tennessee-based venture capital firm founded in 2007 with roots in the Memphis Bioworks Foundation. It focuses on pre-seed, seed, and early-stage investments in high-growth biosciences, technology, and agri-tech companies in Tennessee. The firm supports startups from concept to market by providing capital, strategic guidance, and access to industry networks, including connections with established corporations for licensing, buy-outs, or further investments. By combining experienced management, market expertise, and venture capital, Innova Memphis aims to accelerate product development and create viable business units capable of standing independently and collaborating with mature market leaders when appropriate.

Mountain Group Capital, LLC is a venture capital and private equity firm founded in 2002 and based in Nashville, Tennessee. The firm specializes in seed, early-stage, venture equity, buyouts, growth capital, and later-stage investments, primarily targeting the life sciences, animal health, and technology sectors. Within life sciences, it emphasizes MedTech, medical devices, diagnostics, nutraceuticals, and expedited drug development. In the animal health sector, the firm focuses on technologies that enhance companion animal health and agricultural practices. Mountain Group Capital also invests in disruptive technologies that feature innovative business models with manageable development risk and a swift path to market. The firm seeks investment opportunities in North America, particularly in the Southeastern United States and Tennessee, typically targeting companies with revenues between $1 million and $50 million. It generally prefers to acquire minority interests in venture capital investments while aiming for controlling interests in buyout transactions.

Frist Cressey Ventures is a Nashville-based venture capital firm focused on healthcare and digital health. Founded in the mid-2010s, it makes early- and growth-stage investments in technology and service businesses that offer viable solutions to improve quality of care, system integration, patient outcomes, and population health. The firm emphasizes value-added partnerships to accelerate growth and scale within the healthcare sector.

Founded in 2009, TriStar Health Partners is a venture capital firm specializing in early-stage investments, primarily focusing on healthcare innovation. It invests in life sciences, diagnostics, medical devices and technologies, IT, and healthcare services companies, with a preference for those based in the Southeast United States, particularly Tennessee.

DC Investment Partners is a venture capital firm headquartered in McLean, Virginia, with an additional office in Nashville. It invests in early and growth-stage companies, targeting teams with strong leadership, proven market acceptance, and a competitive edge. The firm typically makes investments up to $10 million and provides strategic guidance to help portfolio companies scale. Founded in 2019, it operates as a private investment partner focused on helping ambitious companies accelerate growth.

Clayton Associates is a Nashville-based family office that makes seed to early-stage investments in healthcare and technology companies in the United States. Founded in 1996, it concentrates on healthcare technology, digital health, information technology, software, and technology-enabled services, and favors opportunities in the Southeast and Southwest United States. The firm typically makes equity investments ranging from about 0.5 million to 6 million, with enterprise values of 3 million to 15 million, and can participate in seed rounds of up to 0.5 million. It seeks minority stakes of roughly 20% to 40% and also engages in angel investments. Clayton Associates works through affiliates and partnerships, including Bullpen Ventures and Rolling Hills Ventures, via its venture-capital manager FCA Venture Partners. The firm is based in Brentwood and Nashville, Tennessee, with a history of supporting entrepreneurs and building growth in the healthcare and technology sectors.

Founded in 2009 and based in Nashville, Tennessee, Martin Ventures is a venture capital firm primarily focused on healthcare and technology initiatives. The company provides capital, operational support, and mentoring to assist entrepreneurs in scaling their businesses into successful, profitable organizations.

Heritage Group, LLC, established in 1986, is a Nashville, Tennessee-based venture capital firm specializing in healthcare investments. It provides early-stage and growth capital, typically investing up to $15 million per company, with a preference for healthcare services, healthcare IT, and technology-enabled services sectors. The firm seeks board participation in its portfolio companies and has a track record of investing in, operating, and advising innovative healthcare businesses.

FCA Venture Partners is a Nashville-based venture capital firm with roots in Clayton Associates and the McWhorter family. Founded in 1996, it has a long history of investing in healthcare entrepreneurs and aims to build sustainable businesses by providing strategic value to portfolio companies. The firm backs seed- to later-stage companies across healthcare, healthcare technology, software, SaaS, and technology-enabled services in the United States, and it operates as a registered investment adviser. By combining capital with hands-on guidance, FCA Venture Partners supports growth-oriented companies seeking to improve care quality and patient experience while expanding market reach.

Dynamo Ventures is a venture capital firm based in Chattanooga, Tennessee, founded in 2016. It concentrates on seed-stage and pre-seed opportunities in the supply chain and mobility sectors, investing in enterprise business models and supporting founding teams as they build market-defining companies.

Claritas Capital is a Nashville-based private investment firm that provides capital to health care, technology, business services, and real estate companies. It engages in venture capital and private equity, including acquisitions and mezzanine financing, with a focus on seed through growth stages and late-stage opportunities. The firm targets healthcare delivery, payment systems, medical devices, health care technology, information services, software-enabled services, digital media, and other disruptive technologies, emphasizing cost containment and efficiency improvements. It typically invests in the Southeast United States and Texas, with consideration for other regions. Equity investments generally range from 0.25 million to 5 million and mezzanine investments from 1 million to 10 million, often in the form of subordinated debt with warrants. The firm prefers to be the leading institutional investor and seeks a board of directors seat or observation rights for mezzanine financing. Claritas Capital maintains offices in Nashville, Irvine, and Newport Beach, California.

Blank Slate Ventures is a Chattanooga-based venture capital firm founded in 2011 that invests in early-stage, pre-revenue startups in the Chattanooga region. It supports entrepreneurial teams with the potential to disrupt industries, and has a history of notable early bets, including an initial investment in Quickcue that led to a sale to OpenTable. The firm has expanded its focus to software, technology, media and related sectors, reflecting its emphasis on high-growth opportunities within the local ecosystem.

Altitude Ventures is a Nashville, Tennessee-based venture capital firm focused on early-stage investments in healthcare services and technology startups. Founded in 2012, it supports portfolio companies through value-added partnerships and draws on industry expertise and relationships to help entrepreneurs scale and advance healthcare innovation.

The Chattanooga Renaissance Fund is an angel investment group and venture capital network based in Chattanooga, Tennessee. It pursues seed and early-stage investments in startups located in Chattanooga and surrounding markets, including Knoxville, Nashville, and the northern Atlanta region. Founded in the early 2010s, the organization aims to broaden access to capital and mentorship for local entrepreneurs, helping to fuel growth and sustain a vibrant entrepreneurial ecosystem in the Tennessee Valley and adjacent areas.

Founded in 2017, IAG Capital Partners is a venture capital firm based in Charleston, South Carolina. It invests in seed to series C rounds across various stages and structures.

Founded in 2013, The JumpFund is a venture capital firm headquartered in Chattanooga, Tennessee. It primarily invests in seed and early-stage female-led ventures across the Southeast U.S., focusing on sectors such as business products/services, consumer products/services, healthcare, edtech, fintech, and mobile.

Solas BioVentures is a Chattanooga, Tennessee-based venture capital firm focused on early-stage investments in biotechnology, medical devices, diagnostics and digital health technologies, along with related medical opportunities. Founded in 2014, the firm backs early-stage companies in biotech, devices and diagnostics, aiming to accelerate medical innovation from the Chattanooga region and beyond.

Established in 2018 and headquartered in Nashville, Tennessee, Russell Street Ventures is a specialized healthcare company dedicated to launching and growing businesses that cater to some of the nation's most vulnerable and underserved patient populations.

Crimson Ventures is a global venture capital firm founded in 1993 with offices in Menlo Park, Hong Kong, Taipei, Tokyo and Nashville. It invests in technology and infrastructure companies across sectors including e-Business infrastructure, communications, financial services, real estate, industrial and healthcare.

Founded in 2015, Greater Sum Ventures is an entrepreneurial growth equity firm based in Knoxville, Tennessee. The company specializes in investing in lower-middle market tech-enabled business services companies, with a focus on software and technology-enabled information services.

FINTOP Capital is a venture capital firm based in Nashville, Tennessee, founded in 2016. It targets B2B software-as-a-service companies in the fintech space that have a proven product, real revenues, and leadership with industry experience. The firm maintains additional offices in Hoboken, New Jersey, and St. Louis, Missouri.

Relevance Ventures is an early-stage venture capital firm based in Brentwood, Tennessee, focusing on fintech, enterprise software, health tech, internet of things, and health and wellness solutions. The firm originated from a public-private partnership with the state of Tennessee supporting regional technology investments and now targets opportunities across the United States, deploying capital typically in the range of $250,000 to $2.5 million per financing round depending on stage and potential. It emphasizes entrepreneur-friendly partnerships, supports founders with robust guidance and networking, and seeks to build long-term relationships through a collaborative deal-making approach, often syndicating deals through its extensive network. Two principal general partners are members of the Patawomeck Indian Tribe of Virginia, making Relevance Ventures one of the few Native-owned independent early-stage venture firms in the United States.

River Street Management is a venture capital firm founded in 2008 and based in Memphis, Tennessee, that invests in private companies, supporting both mature operating businesses and later-stage ventures, with a portfolio focus on property, insurance, medical devices, healthcare technology, wireless telecommunications, identity protection, and retail sectors.

JumpStart Capital, established in 2001 and headquartered in San Francisco, is a venture capital and private equity firm. It specializes in seed, early, and growth stage investments, primarily in new and emerging technologies, digital media, and digital entertainment. The firm also invests in distressed and undervalued real estate opportunities, with a focus on the United States, Australia, and New Zealand. JumpStart Capital aims to align investors with innovative companies that have high growth potential and superior risk-adjusted returns.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, established in 2013. It targets individual accredited investors who previously had limited access to venture capital by enabling alumni from top entrepreneurial schools to invest together in ventures led by fellow alumni. The firm backs companies with an alumni connection and an institutional lead investor with sector expertise. It offers focused funds that provide accredited investors access to a diversified venture portfolio by type, sector, stage, and geography. The organization engages in seed, early-stage, and late-stage pre-IPO investments across technology, consumer, financial services, health care, life sciences, and other sectors.

Insight Partners is a global software investor that partners with growth-stage technology and software companies. Headquartered in New York City with offices in London, Tel Aviv, and Palo Alto, it concentrates on growth-stage software, internet, and data services, with notable focus areas including fintech, cybersecurity, AI/ML, DevOps, and healthcare. Founded in 1995, Insight Partners manages over $75 billion in regulatory assets under management and has invested in more than 750 companies worldwide, with over 55 portfolio companies achieving an IPO. The firm combines capital with hands-on, right-sized software expertise to support portfolio companies on their growth journey from first investment to IPO.

Richland Ventures was a venture capital firm founded in Nashville, Tennessee in 1994. It specialized in providing expansion capital to healthcare service companies, medical devices, technology, and other diversified service companies across the Southeast, Midwest, and Southwest United States.

Rubicon Founders is an entrepreneurial firm established in 2021 and based in Nashville, Tennessee. The company is dedicated to building and growing transformational companies, primarily focusing on the healthcare sector. As a Registered Investment Adviser, Rubicon Founders aims to identify and invest in innovative opportunities within this industry, leveraging its expertise to support the development of impactful businesses.

Founded in 2014, Rugosa Partners is a venture capital firm headquartered in Franklin, Tennessee. The company invests in innovative private market companies across various sectors including healthcare, entertainment, financial services, aviation, manufacturing and distribution, technology, and security.

First In is a venture capital firm established in 2020 and located in Nashville, Tennessee. The firm focuses on investing in companies that tackle significant opportunities and challenges faced by commercial and government enterprises due to the exponential growth of data. First In primarily targets firms that specialize in data and security, seeking to support innovative solutions from inception to seed stage. By concentrating on modern security technologies, First In aims to enhance both enterprise operations and societal safety.

Jumpstart Health Investors, founded in 2013 and based in Nashville, Tennessee, is a venture capital firm focused on investing in the healthcare and wellness sectors. The company employs a systematic approach to private equity healthcare investing, aiming to create opportunities for investors while addressing critical factors such as access, risk mitigation, diversification, and portfolio management. By offering a family of funds tailored to various investor profiles and risk appetites, Jumpstart Health Investors seeks to facilitate strategic investments that contribute to advancements in healthcare.

Mucker Capital is a California-based venture capital firm that funds early-stage technology companies, specializing in Internet software, services and media with a focus on Enterprise, fintech, B2B and consumer products. It targets pre-seed to Series A rounds and seeks opportunities outside Silicon Valley, particularly in Los Angeles and broader Southern California as well as other underfunded ecosystems in the United States and Canada. The firm typically invests between $0.25 million and $1 million per deal and operates MuckerLab, an accelerator program whose duration ranges from three to twenty-four months to help portfolio companies grow. The firm is headquartered in Santa Monica and maintains an additional office in Nashville.

Brickyard is a venture capital firm based in Chattanooga, Tennessee, founded in 2021. It provides early-stage capital and acts as a founder outpost that supports builders creating new technology. The firm targets pre-seed and seed-stage investments, with a focus on healthcare technology, and works with founders from around the world within a collaborative community that helps them pursue product-market fit.

Caduceus Capital Partners is a Nashville-based venture capital firm focused on early-stage digital health investments. Founded in 2020, it backs companies that leverage digitization to enable new care delivery models and drive innovation in health care, supporting ventures that address emerging needs in digital health through technology and services that improve patient outcomes and care efficiency.

Founded in Memphis, Tennessee in 2019, Ridgeline is an early-stage venture capital firm investing in transformative technologies and businesses across software and hardware sectors. The company leverages its expertise and network to support founders navigating the path from product potential to market fit.

Founded in 2023 and headquartered in Nashville, Tennessee, Blue Hour Ventures is a venture capital firm focused on investing in early-stage companies driving innovation within America's healthcare system.

77 Ventures is a principal investment firm located in New York, with an additional office in Nashville, Tennessee. Specializing in venture capital, the firm focuses on identifying and investing in innovative startups and emerging companies. As a boutique team, 77 Ventures aims to provide tailored support and resources to its portfolio companies, fostering growth and development in various industries. The firm is committed to building strong partnerships with entrepreneurs and supporting their visions for success.

Founded in 2013, Powered Health is a venture capital firm based in Nashville, Tennessee. It focuses on investing in healthcare technology startups.

Oak HC/FT is a venture and growth equity investment firm specializing in healthcare information services and financial technology. It supports portfolio companies with strategic counsel, board-level participation, and access to a broad network of industry leaders to drive transformation in these sectors. The firm, based in Stamford, Connecticut, operates within the Oak Investment Partners family, leveraging sector-specific expertise from Oak's healthcare and fintech teams to build and scale innovative businesses.

Solidus Company is a venture capital firm that focuses on early-stage investments in companies at the growth stage.

Citi Ventures is the corporate venture capital arm of Citigroup that leverages the bank’s resources to identify, incubate, and invest in innovative ideas at the intersection of finance and technology. Headquartered in San Francisco with offices in New York, London, Palo Alto, Tel Aviv, and Singapore, Citi Ventures collaborates with Citi colleagues, clients, and the broader innovation community to discover new value and accelerate the development of transformative technologies. The firm focuses on fintech, data analytics and machine learning, the future of commerce, security and enterprise IT, marketing, property technology, distributed ledger technology, and digital assets, pursuing strategic investments that complement Citi’s business lines and risk management capabilities. Since its founding, Citi Ventures has sought to build partnerships and portfolios that support entrepreneurship and technological progress, helping individuals, businesses, and communities adapt to rapid digital change while expanding Citi’s ecosystem and capabilities.

Service Provider Capital is a venture capital firm established in 2014 and based in Colorado. The firm focuses on early-stage investments, notably seed-stage opportunities, and participates as a co-investor in Series A rounds led by institutional venture funds. Its portfolio interests span a broad range of technology sectors, including artificial intelligence, machine learning, blockchain, cybersecurity, e-commerce, education technology, fintech, hardware, information technology, robotics, health, and cannabis.

Liquid 2 Ventures is a San Francisco-based venture capital firm founded in 2015 that provides seed- and early-stage capital to technology startups. The firm supports founders across technology sectors and seeks to partner with ambitious teams developing innovative software and related technologies.

Norwest Venture Partners is a venture capital and growth equity firm founded in 1961 and headquartered in California, with a presence in Menlo Park and Palo Alto. It backs technology-driven companies across stages, from seed to growth, primarily in the United States, with extensions into India and Israel. The firm invests in sectors including software, information services, business services, financial services, healthcare, enterprise technology, and consumer products and services. Norwest emphasizes a proactive, partnership-based approach, leveraging its extensive network, operating experience, and a broad range of resources to help CEOs and founders scale their businesses. Across its portfolio, Norwest has supported hundreds of companies through multiple rounds of financing, aiming to partner with teams that demonstrate strong market position, revenue traction, and durable growth potential. The firm seeks to combine capital with strategic guidance, enabling portfolio companies to accelerate product development, go-to-market execution, and international expansion where appropriate.

Foundation Capital is a United States-based venture capital firm founded in 1995 and headquartered in Palo Alto, California. It backs startups across sectors including software, enterprise IT, data, security and privacy, fintech, consumer technology, and digital energy, with investments ranging from early-stage to growth-stage opportunities. The firm states a hands-on approach, often serving as the lead investor and taking board seats to help portfolio companies scale. Its portfolio has included notable technology companies such as Netflix, LendingClub, Sunrun, AdRoll, and ForgeRock, among others, and several exits through IPOs and acquisitions. Foundation Capital emphasizes founder support and practical operational guidance, aiming to support entrepreneurs who can transform markets through software, data-enabled services, and digital infrastructure.

Jaws Ventures provides growth capital to companies, focusing on those operating in the consumer and technology sectors.

Founded in 2022, Balerion Space Ventures is a Dallas-based venture capital firm focused on investing in early to mid-stage private space companies.

Hanaco Ventures is a venture capital firm founded in 2017 and based in Tel Aviv, Israel. It backs early-stage technology startups led by Israeli entrepreneurs worldwide and seeks opportunities in the United States and Israel. The firm focuses on consumer products and services, food and agricultural technology, digital healthcare, financial technology, and information technology.

Founded in 2024, Beyond Earth is a venture capital firm based in Wilmington, Delaware. It invests in early-stage companies developing innovative technologies at the intersection of space tech and advanced terrestrial deep tech.

RiverPark Ventures is a New York-based venture capital firm founded in 2006 that backs early-stage technology companies. The firm focuses on sectors including fintech, edtech, ecommerce, software as a service, and hospitality, and emphasizes enterprise technology and shifts in consumer behavior. It operates as a registered investment adviser and aims to support startups through capital and guidance as they scale.