Innova Memphis is a Tennessee-based venture capital firm established in 2007 by the Memphis Bioworks Foundation. It focuses on biosciences, technology, and agri-tech companies at pre-seed, seed, early-stage, and high-growth stages across the United States. The firm provides funding and hands-on support to help early ideas evolve into viable business units and aims to connect portfolio companies with established corporations for licensing, acquisitions, or follow-on investments. By combining technical know-how, market expertise, and venture capital, Innova Memphis seeks to accelerate product development and help startups reach milestones and scale toward market leadership.

Mountain Group Capital, LLC is a venture capital and private equity firm founded in 2002 and based in Nashville, Tennessee. The firm specializes in seed, early-stage, venture equity, buyouts, growth capital, and later-stage investments, primarily targeting the life sciences, animal health, and technology sectors. Within life sciences, it emphasizes MedTech, medical devices, diagnostics, nutraceuticals, and expedited drug development. In the animal health sector, the firm focuses on technologies that enhance companion animal health and agricultural practices. Mountain Group Capital also invests in disruptive technologies that feature innovative business models with manageable development risk and a swift path to market. The firm seeks investment opportunities in North America, particularly in the Southeastern United States and Tennessee, typically targeting companies with revenues between $1 million and $50 million. It generally prefers to acquire minority interests in venture capital investments while aiming for controlling interests in buyout transactions.

MB Venture Partners is a Memphis, Tennessee-based venture capital firm that provides equity capital and strategic direction to life sciences companies. The firm invests in medical devices and biotechnology at all stages of development and has a particular focus on product solutions for musculoskeletal diseases, leveraging deep experience and relationships in that area. Founded in 2001, MB Venture Partners pursues early-stage investments in medical devices and biotechnology across the United States, with activity in healthcare, life sciences, oncology, digital health, health technology, nanotechnology, and related fields in the Southeast and Midwest.

Founded in 2009 and based in Nashville, Tennessee, Martin Ventures is a venture capital firm primarily focused on healthcare and technology initiatives. The company provides capital, operational support, and mentoring to assist entrepreneurs in scaling their businesses into successful, profitable organizations.

Frist Cressey Ventures is a venture capital firm headquartered in Nashville, Tennessee, focused on early- and growth-stage investments in healthcare and digital health technologies and services. It seeks opportunities that improve quality of care, system integration, patient outcomes, and population health, partnering with entrepreneurs to accelerate growth and translate viable solutions into practical healthcare improvements. The firm targets technology-enabled healthcare enterprises and service businesses with strong potential to advance care delivery and health outcomes, and it emphasizes value-added collaboration with portfolio companies.

Founded in 2009, TriStar Health Partners is a venture capital firm specializing in early-stage investments, primarily focusing on healthcare innovation. It invests in life sciences, diagnostics, medical devices and technologies, IT, and healthcare services companies, with a preference for those based in the Southeast United States, particularly Tennessee.

DC Investment Partners is a venture capital firm headquartered in McLean, Virginia, with an additional office in Nashville. It invests in early and growth-stage companies, targeting teams with strong leadership, proven market acceptance, and a competitive edge. The firm typically makes investments up to $10 million and provides strategic guidance to help portfolio companies scale. Founded in 2019, it operates as a private investment partner focused on helping ambitious companies accelerate growth.

Clayton Associates is a Nashville-based family office that makes seed to early-stage investments in healthcare and technology companies in the United States. Founded in 1996, it concentrates on healthcare technology, digital health, information technology, software, and technology-enabled services, and favors opportunities in the Southeast and Southwest United States. The firm typically makes equity investments ranging from about 0.5 million to 6 million, with enterprise values of 3 million to 15 million, and can participate in seed rounds of up to 0.5 million. It seeks minority stakes of roughly 20% to 40% and also engages in angel investments. Clayton Associates works through affiliates and partnerships, including Bullpen Ventures and Rolling Hills Ventures, via its venture-capital manager FCA Venture Partners. The firm is based in Brentwood and Nashville, Tennessee, with a history of supporting entrepreneurs and building growth in the healthcare and technology sectors.

Heritage Group, LLC, established in 1986, is a Nashville, Tennessee-based venture capital firm specializing in healthcare investments. It provides early-stage and growth capital, typically investing up to $15 million per company, with a preference for healthcare services, healthcare IT, and technology-enabled services sectors. The firm seeks board participation in its portfolio companies and has a track record of investing in, operating, and advising innovative healthcare businesses.

FCA Venture Partners is a venture capital investment firm based in Nashville, Tennessee, established in 1996. It focuses on investing in healthcare and related technology companies at seed to later stages, frequently committing 3 to 6 million dollars per investment. The firm seeks to accelerate growth by funding healthcare products, services, and software that streamline processes, enhance quality of care, and improve the patient experience. It maintains deep ties to the Nashville healthcare community and has historical links with Clayton Associates and the McWhorter family, reflecting its local roots and collaborative approach to building sustainable healthcare businesses.

Dynamo Ventures is a venture capital firm based in Chattanooga, Tennessee, founded in 2016. It focuses on seed-stage investing in the supply chain and mobility sectors, supporting founding teams building market-defining, enterprise-focused companies and prioritizing pre-seed and seed opportunities.

Claritas Capital is a Nashville-based private investment firm that provides capital to health care, technology, business services, and real estate companies. It engages in venture capital and private equity, including acquisitions and mezzanine financing, with a focus on seed through growth stages and late-stage opportunities. The firm targets healthcare delivery, payment systems, medical devices, health care technology, information services, software-enabled services, digital media, and other disruptive technologies, emphasizing cost containment and efficiency improvements. It typically invests in the Southeast United States and Texas, with consideration for other regions. Equity investments generally range from 0.25 million to 5 million and mezzanine investments from 1 million to 10 million, often in the form of subordinated debt with warrants. The firm prefers to be the leading institutional investor and seeks a board of directors seat or observation rights for mezzanine financing. Claritas Capital maintains offices in Nashville, Irvine, and Newport Beach, California.

Blank Slate Ventures is a Chattanooga-based venture capital firm founded in 2011 that invests in early-stage, pre-revenue startups in the Chattanooga region. It supports entrepreneurial teams with the potential to disrupt industries, and has a history of notable early bets, including an initial investment in Quickcue that led to a sale to OpenTable. The firm has expanded its focus to software, technology, media and related sectors, reflecting its emphasis on high-growth opportunities within the local ecosystem.

Founded in 2012, Altitude Ventures is a venture capital firm based in Nashville, Tennessee. It specializes in early-stage investments, focusing on healthcare services and technology startups that improve healthcare outcomes.

Chattanooga Renaissance Fund is a venture capital firm and angel investment network based in Chattanooga, Tennessee. It focuses on seed and early-stage opportunities in Chattanooga and surrounding markets, including Knoxville, Nashville, and the north corner of Atlanta, providing capital and mentorship to entrepreneurs to fuel growth and innovation in the region. By assembling investors and mentors into a formal network, it seeks to support the next generation of regional startups and strengthen the area's entrepreneurial ecosystem.

Founded in 2013, The JumpFund is a venture capital firm headquartered in Chattanooga, Tennessee. It primarily invests in seed and early-stage female-led ventures across the Southeast U.S., focusing on sectors such as business products/services, consumer products/services, healthcare, edtech, fintech, and mobile.

Solas BioVentures is a venture capital firm based in Chattanooga, Tennessee, that backs early-stage opportunities in biopharmaceuticals, medical devices, diagnostics and digital health. The firm provides capital to early-stage companies developing healthcare products and related technologies in the life sciences and medical technology sectors. Since its founding in 2014, Solas BioVentures has focused on supporting startups at the intersection of medicine and technology, helping teams advance products from concept toward clinical development and market readiness.

Established in 2018 and headquartered in Nashville, Tennessee, Russell Street Ventures is a specialized healthcare company dedicated to launching and growing businesses that cater to some of the nation's most vulnerable and underserved patient populations.

Founded in 2017, IAG Capital Partners is a venture capital firm based in Charleston, South Carolina. It invests in seed to series C rounds across various stages and structures.

Crimson Ventures is a global venture capital firm founded in 1993 with offices in Menlo Park, Hong Kong, Taipei, Tokyo and Nashville. It invests in technology and infrastructure companies across sectors including e-Business infrastructure, communications, financial services, real estate, industrial and healthcare.

Salix Ventures, established in 1997, was a venture capital firm headquartered in Nashville, Tennessee, with additional offices in San Francisco and Andover. It specialized in investing in healthcare services and healthcare information technology companies, with a focus on provider-based businesses, payors, and pharmaceutical services. The firm was stage-agnostic, investing in early to late-stage companies, typically committing $2.5 to $7 million per company, with half invested initially and similar amounts reserved for follow-on rounds. Salix Ventures preferred to co-invest and sought active involvement in its portfolio companies. It invested in companies based in the United States, with a focus on Tennessee and the Southeast. The firm ceased operations on January 25, 2019.

Founded in 2015, Greater Sum Ventures is an entrepreneurial growth equity firm based in Knoxville, Tennessee. The company specializes in investing in lower-middle market tech-enabled business services companies, with a focus on software and technology-enabled information services.

FINTOP Capital, established in 2016, is a venture capital firm based in Nashville, Tennessee, with additional offices in Hoboken, New Jersey, and St. Louis, Missouri. The firm specializes in investing in early-stage, B2B service-enabled SaaS and software companies operating in the FinTech sector. FINTOP Capital targets companies with a proven product, real revenues, and leadership teams composed of industry veterans.

Founded in 2012, Relevance Ventures is an early-stage venture firm based in Brentwood, Tennessee. It focuses on investing in fintech/enterprise software and health + wellness solutions sectors. With over $115M in assets under management, the firm deploys capital ranging from $250K to $2.5M per round, depending on stage and potential. Relevance is known for its entrepreneur-friendly approach, aiming to create mutually beneficial opportunities and long-lasting partnerships with founding teams.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, with offices across North America. It provides access to venture investing for individual accredited investors, particularly alumni networks, by offering diversified portfolios of venture opportunities and allowing members to invest alongside fellow alumni in ventures led by peers. The firm backs early-stage and later-stage opportunities across technology, consumer, healthcare, financial services, and other sectors, with a sector- and geography-agnostic approach. It typically invests between $10,000 and $3 million per deal and emphasizes the involvement of alumni connections and an institutional lead investor in opportunities. Alumni Ventures also offers focused funds to broaden participation, enabling accredited investors to access venture portfolios diversified by type, sector, stage, and geography. The model aims to democratize access to venture capital while maintaining rigorous selection standards through alumni networks.

River Street Management is a venture capital firm founded in 2008 and based in Memphis, Tennessee, that invests in private companies, supporting both mature operating businesses and later-stage ventures, with a portfolio focus on property, insurance, medical devices, healthcare technology, wireless telecommunications, identity protection, and retail sectors.

Insight Partners is a global private equity and venture capital firm founded in 1995 that acts as a software investor, partnering with growth-stage technology and software companies. The firm concentrates on Fintech, Cybersecurity, AI/ML, DevOps, and Healthcare, providing capital and hands-on support to help management teams scale. Headquartered in New York City with offices in London, Tel Aviv, and Palo Alto, Insight Partners has more than $75 billion in assets under management, has invested in over 750 companies worldwide, and more than 55 portfolio companies have reached an IPO.

Jumpstart Health Investors, founded in 2013 and based in Nashville, Tennessee, is a venture capital firm focused on investing in the healthcare and wellness sectors. The company employs a systematic approach to private equity healthcare investing, aiming to create opportunities for investors while addressing critical factors such as access, risk mitigation, diversification, and portfolio management. By offering a family of funds tailored to various investor profiles and risk appetites, Jumpstart Health Investors seeks to facilitate strategic investments that contribute to advancements in healthcare.

First In is a venture capital firm established in 2020 and located in Nashville, Tennessee. The firm focuses on investing in companies that tackle significant opportunities and challenges faced by commercial and government enterprises due to the exponential growth of data. First In primarily targets firms that specialize in data and security, seeking to support innovative solutions from inception to seed stage. By concentrating on modern security technologies, First In aims to enhance both enterprise operations and societal safety.

Mucker Capital is a California-based venture capital firm that funds early-stage technology companies, specializing in Internet software, services and media with a focus on Enterprise, fintech, B2B and consumer products. It targets pre-seed to Series A rounds and seeks opportunities outside Silicon Valley, particularly in Los Angeles and broader Southern California as well as other underfunded ecosystems in the United States and Canada. The firm typically invests between $0.25 million and $1 million per deal and operates MuckerLab, an accelerator program whose duration ranges from three to twenty-four months to help portfolio companies grow. The firm is headquartered in Santa Monica and maintains an additional office in Nashville.

Richland Ventures was a venture capital firm founded in Nashville, Tennessee in 1994. It specialized in providing expansion capital to healthcare service companies, medical devices, technology, and other diversified service companies across the Southeast, Midwest, and Southwest United States.

Jumpstart Nova is a venture capital investment firm focused on early-stage healthcare startups. Founded in 2020 and headquartered in Nashville, Tennessee, with a regional office in Los Angeles, California, the firm targets seed and Series A companies in health IT, digital health, tech-enabled services, consumer health and wellness, and Medicaid services across the United States. It supports portfolio companies by providing strategic insight drawn from leadership across the healthcare industry to accelerate growth and scale. The firm emphasizes tech-enabled services and digital health solutions that address efficiencies and outcomes in healthcare delivery and patient care.

Founded in 2013, Powered Health is a venture capital firm based in Nashville, Tennessee. It focuses on investing in healthcare technology startups.

Founded in Memphis, Tennessee in 2019, Ridgeline is an early-stage venture capital firm investing in transformative technologies and businesses across software and hardware sectors. The company leverages its expertise and network to support founders navigating the path from product potential to market fit.

Caduceus Capital Partners is a Nashville-based venture capital firm focused on early-stage digital health investments. Founded in 2020, it backs companies that leverage digitization to enable new care delivery models and drive innovation in health care, supporting ventures that address emerging needs in digital health through technology and services that improve patient outcomes and care efficiency.

Brickyard is a venture capital firm based in Chattanooga, Tennessee, founded in 2021. It provides early-stage capital and acts as a founder outpost that supports builders creating new technology. The firm targets pre-seed and seed-stage investments, with a focus on healthcare technology, and works with founders from around the world within a collaborative community that helps them pursue product-market fit.

Rubicon Founders is an entrepreneurial firm established in 2021 and based in Nashville, Tennessee. The company is dedicated to building and growing transformational companies, primarily focusing on the healthcare sector. As a Registered Investment Adviser, Rubicon Founders aims to identify and invest in innovative opportunities within this industry, leveraging its expertise to support the development of impactful businesses.

77 Ventures is a principal investment firm located in New York, with an additional office in Nashville, Tennessee. Specializing in venture capital, the firm focuses on identifying and investing in innovative startups and emerging companies. As a boutique team, 77 Ventures aims to provide tailored support and resources to its portfolio companies, fostering growth and development in various industries. The firm is committed to building strong partnerships with entrepreneurs and supporting their visions for success.

Founded in 2014, Rugosa Partners is a venture capital firm headquartered in Franklin, Tennessee. The company invests in innovative private market companies across various sectors including healthcare, entertainment, financial services, aviation, manufacturing and distribution, technology, and security.

Founded in 2023 and headquartered in Nashville, Tennessee, Blue Hour Ventures is a venture capital firm focused on investing in early-stage companies driving innovation within America's healthcare system.

Oak HC/FT is a venture and growth equity investment firm specializing in healthcare information services and financial technology. It supports portfolio companies with strategic counsel, board-level participation, and access to a broad network of industry leaders to drive transformation in these sectors. The firm, based in Stamford, Connecticut, operates within the Oak Investment Partners family, leveraging sector-specific expertise from Oak's healthcare and fintech teams to build and scale innovative businesses.

Solidus Company is a venture capital firm that focuses on early-stage investments in companies at the growth stage.

Founded in 2009, Ludlow Ventures is a Michigan-based venture capital firm specializing in early-stage investments. It focuses on technology companies across the United States, typically investing between $25,000 and $150,000 per company. Known for its straightforward approach, it aims to build trust and friendship with invested teams.

Founded in 2013, Annox Capital is a venture capital firm based in Birmingham, Michigan. It invests in companies that employ disruptive technology or online strategies to significantly improve business processes or human experiences across various sectors such as manufacturing, logistics, banking, healthcare, and real estate.

Detroit Venture Partners is a Detroit-based venture capital firm that focuses on seed and early-stage technology investments across the United States, with emphasis on Detroit and Ontario. The firm backs internet, digital media, marketing technology, direct-to-consumer, sports and entertainment, social media, e-commerce, software, B2B software, mobile applications, and related sectors such as Adtech and enterprise software-as-a-service. It typically makes initial investments in the range of USD 0.25 to 0.75 million, with follow-on rounds between 2 and 3 million, and can participate up to about 3 million per investment. Founded in 2010, it aims to support entrepreneurial ventures that help rebuild the Detroit area and foster growth in technology-driven businesses.

Service Provider Capital is a venture capital firm established in 2014 and based in Colorado. The firm focuses on early-stage investments, notably seed-stage opportunities, and participates as a co-investor in Series A rounds led by institutional venture funds. Its portfolio interests span a broad range of technology sectors, including artificial intelligence, machine learning, blockchain, cybersecurity, e-commerce, education technology, fintech, hardware, information technology, robotics, health, and cannabis.

Liquid 2 Ventures is a San Francisco-based venture capital firm founded in 2015 that provides seed- and early-stage capital to technology startups. The firm supports founders across technology sectors and seeks to partner with ambitious teams developing innovative software and related technologies.

Norwest Venture Partners is a venture capital and growth equity firm founded in 1961 and headquartered in California, with a presence in Menlo Park and Palo Alto. It backs technology-driven companies across stages, from seed to growth, primarily in the United States, with extensions into India and Israel. The firm invests in sectors including software, information services, business services, financial services, healthcare, enterprise technology, and consumer products and services. Norwest emphasizes a proactive, partnership-based approach, leveraging its extensive network, operating experience, and a broad range of resources to help CEOs and founders scale their businesses. Across its portfolio, Norwest has supported hundreds of companies through multiple rounds of financing, aiming to partner with teams that demonstrate strong market position, revenue traction, and durable growth potential. The firm seeks to combine capital with strategic guidance, enabling portfolio companies to accelerate product development, go-to-market execution, and international expansion where appropriate.

Citi Ventures is the corporate venture capital arm of Citigroup that leverages the bank’s resources to identify, incubate, and invest in innovative ideas at the intersection of finance and technology. Headquartered in San Francisco with offices in New York, London, Palo Alto, Tel Aviv, and Singapore, Citi Ventures collaborates with Citi colleagues, clients, and the broader innovation community to discover new value and accelerate the development of transformative technologies. The firm focuses on fintech, data analytics and machine learning, the future of commerce, security and enterprise IT, marketing, property technology, distributed ledger technology, and digital assets, pursuing strategic investments that complement Citi’s business lines and risk management capabilities. Since its founding, Citi Ventures has sought to build partnerships and portfolios that support entrepreneurship and technological progress, helping individuals, businesses, and communities adapt to rapid digital change while expanding Citi’s ecosystem and capabilities.

Foundation Capital is a United States–based venture capital firm founded in 1995 that invests in early- to growth-stage information technology and software-enabled companies. The firm backs startups across sectors including enterprise software, IT infrastructure and services, cloud and website infrastructure, data platforms, cybersecurity and privacy, fintech, consumer technology, digital energy, marketing technology, and telecommunications, with an emphasis on enterprise applications, on-demand services, and data networks. It pursues opportunities primarily in the United States and India, typically making initial commitments in the range of one to ten million dollars and often acting as lead investor with board representation. The team comprises former entrepreneurs who aim to support founders from idea to scale, and its portfolio has included high-growth ventures across consumer, software, digital energy and fintech sectors.