Innova Memphis is a Tennessee-based venture capital firm established in 2007 by the Memphis Bioworks Foundation. It focuses on biosciences, technology, and agri-tech companies at pre-seed, seed, early-stage, and high-growth stages across the United States. The firm provides funding and hands-on support to help early ideas evolve into viable business units and aims to connect portfolio companies with established corporations for licensing, acquisitions, or follow-on investments. By combining technical know-how, market expertise, and venture capital, Innova Memphis seeks to accelerate product development and help startups reach milestones and scale toward market leadership.

Mountain Group Capital, LLC is a venture capital and private equity firm founded in 2002 and based in Nashville, Tennessee. The firm specializes in seed, early-stage, venture equity, buyouts, growth capital, and later-stage investments, primarily targeting the life sciences, animal health, and technology sectors. Within life sciences, it emphasizes MedTech, medical devices, diagnostics, nutraceuticals, and expedited drug development. In the animal health sector, the firm focuses on technologies that enhance companion animal health and agricultural practices. Mountain Group Capital also invests in disruptive technologies that feature innovative business models with manageable development risk and a swift path to market. The firm seeks investment opportunities in North America, particularly in the Southeastern United States and Tennessee, typically targeting companies with revenues between $1 million and $50 million. It generally prefers to acquire minority interests in venture capital investments while aiming for controlling interests in buyout transactions.

Founded in 2009 and based in Nashville, Tennessee, Martin Ventures is a venture capital firm primarily focused on healthcare and technology initiatives. The company provides capital, operational support, and mentoring to assist entrepreneurs in scaling their businesses into successful, profitable organizations.

MB Venture Partners is a Memphis, Tennessee-based venture capital firm that provides equity capital and strategic direction to life sciences companies. The firm invests in medical devices and biotechnology at all stages of development and has a particular focus on product solutions for musculoskeletal diseases, leveraging deep experience and relationships in that area. Founded in 2001, MB Venture Partners pursues early-stage investments in medical devices and biotechnology across the United States, with activity in healthcare, life sciences, oncology, digital health, health technology, nanotechnology, and related fields in the Southeast and Midwest.

Chattanooga Renaissance Fund is a venture capital firm and angel investment network based in Chattanooga, Tennessee. It focuses on seed and early-stage opportunities in Chattanooga and surrounding markets, including Knoxville, Nashville, and the north corner of Atlanta, providing capital and mentorship to entrepreneurs to fuel growth and innovation in the region. By assembling investors and mentors into a formal network, it seeks to support the next generation of regional startups and strengthen the area's entrepreneurial ecosystem.

Frist Cressey Ventures is a venture capital firm headquartered in Nashville, Tennessee, focused on early- and growth-stage investments in healthcare and digital health technologies and services. It seeks opportunities that improve quality of care, system integration, patient outcomes, and population health, partnering with entrepreneurs to accelerate growth and translate viable solutions into practical healthcare improvements. The firm targets technology-enabled healthcare enterprises and service businesses with strong potential to advance care delivery and health outcomes, and it emphasizes value-added collaboration with portfolio companies.

Founded in 2009, TriStar Health Partners is a venture capital firm specializing in early-stage investments, primarily focusing on healthcare innovation. It invests in life sciences, diagnostics, medical devices and technologies, IT, and healthcare services companies, with a preference for those based in the Southeast United States, particularly Tennessee.

DC Investment Partners is a venture capital firm headquartered in McLean, Virginia, with an additional office in Nashville. It invests in early and growth-stage companies, targeting teams with strong leadership, proven market acceptance, and a competitive edge. The firm typically makes investments up to $10 million and provides strategic guidance to help portfolio companies scale. Founded in 2019, it operates as a private investment partner focused on helping ambitious companies accelerate growth.

Clayton Associates, LLC, established in 1996, is a family office based in Brentwood, Tennessee, with additional offices in Nashville, Tennessee, and Houston, Texas. The firm specializes in venture capital investments, focusing on seed, early stage, and growth equity rounds. Clayton Associates prefers to invest in healthcare, healthcare-related services, digital media, and information technology sectors, with a particular interest in healthcare technology, digital health, and software-as-a-service companies. The firm typically invests between $0.5 million and $6 million in companies with enterprise values ranging from $3 million to $15 million and revenues between $0.1 million and $2 million. Clayton Associates seeks minority stakes of 20%-40% in its portfolio companies and also makes angel investments through its affiliate funds. The firm's investment strategy is guided by its extensive operating experience and relationships, aiming to partner with entrepreneurs and help build successful businesses. Since its inception, Clayton Associates has invested in over 100 companies, representing over $7 billion in annualized revenue and the creation of more than 20,000 jobs.

Founded in 2010, Jumpstart Foundry is a venture capital firm specializing in seed-stage investments in healthcare IT, consumer health products/services, tech-enabled services, and diagnostic devices. Based in Nashville, Tennessee with an additional office in Atlanta, Georgia, the firm invests up to $0.15 million per company for 7.5 percent equity. It operates a 14-week program and a six-week Micro-Accelerator program for small to medium-sized companies.

XMi High Growth Development Fund, LLC is a venture capital and private equity firm based in Nashville, Tennessee, and serves as the investment arm of XMi Holdings, Inc. The fund specializes in seed, start-up, early-stage, and growth capital investments, as well as buyouts and ownership restructuring. It focuses on investing in sectors such as healthcare, clean energy, automotive, manufacturing, logistics, business services, and technology. The firm does not engage in investments related to professional services such as accounting or law, banking, real estate development, insurance, oil and gas exploration, or gambling activities. XMi High Growth Development Fund is dedicated to supporting woman-owned and minority-owned businesses, providing them with minority equity or convertible debt investments. In addition to capital, the fund offers various support services that help portfolio companies enhance operational efficiency and focus on revenue generation, fostering scalable and sustainable growth.

Rockmont Partners is a venture capital firm located in Nashville, Tennessee, specializing in investments in early-stage technology-enabled services companies, particularly within the healthcare and fintech sectors. The firm focuses on building comprehensive strategies for its portfolio companies by collaborating with experienced entrepreneurs and operators who serve as mentors to the management teams. This approach aims to guide these companies through their growth phases, fostering innovation and operational excellence in their respective fields.

FCA Venture Partners is a venture capital investment firm based in Nashville, Tennessee, established in 1996. It focuses on investing in healthcare and related technology companies at seed to later stages, frequently committing 3 to 6 million dollars per investment. The firm seeks to accelerate growth by funding healthcare products, services, and software that streamline processes, enhance quality of care, and improve the patient experience. It maintains deep ties to the Nashville healthcare community and has historical links with Clayton Associates and the McWhorter family, reflecting its local roots and collaborative approach to building sustainable healthcare businesses.

Heritage Group, LLC, established in 1986, is a Nashville, Tennessee-based venture capital firm specializing in healthcare investments. It provides early-stage and growth capital, typically investing up to $15 million per company, with a preference for healthcare services, healthcare IT, and technology-enabled services sectors. The firm seeks board participation in its portfolio companies and has a track record of investing in, operating, and advising innovative healthcare businesses.

Dynamo Ventures is a venture capital firm based in Chattanooga, Tennessee, founded in 2016. It focuses on seed-stage investing in the supply chain and mobility sectors, supporting founding teams building market-defining, enterprise-focused companies and prioritizing pre-seed and seed opportunities.

Claritas Capital is a Nashville-based private investment firm that provides capital to health care, technology, business services, and real estate companies. It engages in venture capital and private equity, including acquisitions and mezzanine financing, with a focus on seed through growth stages and late-stage opportunities. The firm targets healthcare delivery, payment systems, medical devices, health care technology, information services, software-enabled services, digital media, and other disruptive technologies, emphasizing cost containment and efficiency improvements. It typically invests in the Southeast United States and Texas, with consideration for other regions. Equity investments generally range from 0.25 million to 5 million and mezzanine investments from 1 million to 10 million, often in the form of subordinated debt with warrants. The firm prefers to be the leading institutional investor and seeks a board of directors seat or observation rights for mezzanine financing. Claritas Capital maintains offices in Nashville, Irvine, and Newport Beach, California.

Blank Slate Ventures is a Chattanooga-based venture capital firm founded in 2011 that invests in early-stage, pre-revenue startups in the Chattanooga region. It supports entrepreneurial teams with the potential to disrupt industries, and has a history of notable early bets, including an initial investment in Quickcue that led to a sale to OpenTable. The firm has expanded its focus to software, technology, media and related sectors, reflecting its emphasis on high-growth opportunities within the local ecosystem.

Founded in 2012, Altitude Ventures is a venture capital firm based in Nashville, Tennessee. It specializes in early-stage investments, focusing on healthcare services and technology startups that improve healthcare outcomes.

Tennessee Community Ventures is a venture capital firm located in Nashville, Tennessee. Established in 2009, the firm focuses on making seed and early-stage investments throughout the state of Tennessee. By concentrating on emerging companies, Tennessee Community Ventures aims to foster innovation and support the growth of local businesses in various sectors.

Founded in 2013, The JumpFund is a venture capital firm headquartered in Chattanooga, Tennessee. It primarily invests in seed and early-stage female-led ventures across the Southeast U.S., focusing on sectors such as business products/services, consumer products/services, healthcare, edtech, fintech, and mobile.

Solas BioVentures is a venture capital firm based in Chattanooga, Tennessee, that backs early-stage opportunities in biopharmaceuticals, medical devices, diagnostics and digital health. The firm provides capital to early-stage companies developing healthcare products and related technologies in the life sciences and medical technology sectors. Since its founding in 2014, Solas BioVentures has focused on supporting startups at the intersection of medicine and technology, helping teams advance products from concept toward clinical development and market readiness.

Established in 2018 and headquartered in Nashville, Tennessee, Russell Street Ventures is a specialized healthcare company dedicated to launching and growing businesses that cater to some of the nation's most vulnerable and underserved patient populations.

Founded in 2017, IAG Capital Partners is a venture capital firm based in Charleston, South Carolina. It invests in seed to series C rounds across various stages and structures.

The Southern Appalachian Fund is a $12.5 million venture capital firm based in Oak Ridge, Tennessee, with an additional office in London, Kentucky. It invests in early and expansion-stage companies operating in the interactive home entertainment, manufacturing, technology, and software sectors, with a focus on small businesses in southern Appalachia, particularly in Kentucky, Tennessee, and the Appalachian counties of Georgia, Alabama, and Mississippi. The fund typically invests between $200,000 and $600,000 in its portfolio companies, often leading investment syndicates or co-investing with other institutional investors and seasoned angel investors. It seeks to generate market-rate returns for its investors while promoting shared and sustainable business growth and wealth creation in its target region. The fund's mission is to provide not only equity capital but also operational assistance, active board participation, and mentoring to its portfolio companies.

Meritus Ventures is a venture capital firm based in London, Kentucky. It makes equity investments in expansion-stage private companies, with a focus on rural areas of central and southern Appalachia. The firm targets opportunities in information technology, industrials, and technology, media, and telecommunications sectors, and its activity spans across Tennessee, Kentucky, Arkansas, and Appalachian counties in Ohio, West Virginia, Virginia, North Carolina, South Carolina, Georgia, Alabama, and Mississippi. It may provide operational support to portfolio companies.

FINTOP Capital, established in 2016, is a venture capital firm based in Nashville, Tennessee, with additional offices in Hoboken, New Jersey, and St. Louis, Missouri. The firm specializes in investing in early-stage, B2B service-enabled SaaS and software companies operating in the FinTech sector. FINTOP Capital targets companies with a proven product, real revenues, and leadership teams composed of industry veterans.

Crimson Ventures is a global venture capital firm founded in 1993 with offices in Menlo Park, Hong Kong, Taipei, Tokyo and Nashville. It invests in technology and infrastructure companies across sectors including e-Business infrastructure, communications, financial services, real estate, industrial and healthcare.

Salix Ventures, established in 1997, was a venture capital firm headquartered in Nashville, Tennessee, with additional offices in San Francisco and Andover. It specialized in investing in healthcare services and healthcare information technology companies, with a focus on provider-based businesses, payors, and pharmaceutical services. The firm was stage-agnostic, investing in early to late-stage companies, typically committing $2.5 to $7 million per company, with half invested initially and similar amounts reserved for follow-on rounds. Salix Ventures preferred to co-invest and sought active involvement in its portfolio companies. It invested in companies based in the United States, with a focus on Tennessee and the Southeast. The firm ceased operations on January 25, 2019.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, with offices across North America. It provides access to venture investing for individual accredited investors, particularly alumni networks, by offering diversified portfolios of venture opportunities and allowing members to invest alongside fellow alumni in ventures led by peers. The firm backs early-stage and later-stage opportunities across technology, consumer, healthcare, financial services, and other sectors, with a sector- and geography-agnostic approach. It typically invests between $10,000 and $3 million per deal and emphasizes the involvement of alumni connections and an institutional lead investor in opportunities. Alumni Ventures also offers focused funds to broaden participation, enabling accredited investors to access venture portfolios diversified by type, sector, stage, and geography. The model aims to democratize access to venture capital while maintaining rigorous selection standards through alumni networks.

Founded in 2012, Relevance Ventures is an early-stage venture firm based in Brentwood, Tennessee. It focuses on investing in fintech/enterprise software and health + wellness solutions sectors. With over $115M in assets under management, the firm deploys capital ranging from $250K to $2.5M per round, depending on stage and potential. Relevance is known for its entrepreneur-friendly approach, aiming to create mutually beneficial opportunities and long-lasting partnerships with founding teams.

River Street Management is a venture capital firm founded in 2008 and based in Memphis, Tennessee, that invests in private companies, supporting both mature operating businesses and later-stage ventures, with a portfolio focus on property, insurance, medical devices, healthcare technology, wireless telecommunications, identity protection, and retail sectors.

Insight Partners is a global software investor that partners with growth-stage technology and software companies. The firm focuses on growth-stage software, internet, and data services, with emphasis on fintech, cybersecurity, artificial intelligence and machine learning, DevOps, and healthcare. Based in New York City with offices in London, Tel Aviv, and Palo Alto, Insight Partners has backed more than 750 companies worldwide and has more than 55 portfolio companies that have achieved an IPO. As of 2022, the firm reports over $75 billion in assets under management. It seeks to fund and work closely with visionary executives, providing practical, hands-on software expertise to support growth from initial investment through to IPO.

Oak HC/FT is a venture and growth equity investment firm specializing in healthcare information services and financial technology. It supports portfolio companies with strategic counsel, board-level participation, and access to a broad network of industry leaders to drive transformation in these sectors. The firm, based in Stamford, Connecticut, operates within the Oak Investment Partners family, leveraging sector-specific expertise from Oak's healthcare and fintech teams to build and scale innovative businesses.

Growth Street Partners is a San Francisco-based private equity and venture capital firm that provides early-stage and growth capital to technology-enabled companies, with a focus on software-as-a-service and related SaaS-enabled services. Founded in 2016, the firm invests across the United States and typically targets investments in the range of $3 million to $10 million, often in companies with annual revenues between $1 million and $5 million. The firm emphasizes scalable software and technology-enabled services opportunities and supports growth and expansion initiatives across the U.S.

Founded in Memphis, Tennessee in 2019, Ridgeline is an early-stage venture capital firm investing in transformative technologies and businesses across software and hardware sectors. The company leverages its expertise and network to support founders navigating the path from product potential to market fit.

Richland Ventures was a venture capital firm founded in Nashville, Tennessee in 1994. It specialized in providing expansion capital to healthcare service companies, medical devices, technology, and other diversified service companies across the Southeast, Midwest, and Southwest United States.

Established in 2023, InvestTN is a venture capital firm headquartered in Nashville, Tennessee. It focuses on investing equity into early-stage startups (Pre-Seed to Series B) and venture capital funds located within Tennessee.

Jumpstart Nova is a venture capital investment firm focused on early-stage healthcare startups. Founded in 2020 and headquartered in Nashville, Tennessee, with a regional office in Los Angeles, California, the firm targets seed and Series A companies in health IT, digital health, tech-enabled services, consumer health and wellness, and Medicaid services across the United States. It supports portfolio companies by providing strategic insight drawn from leadership across the healthcare industry to accelerate growth and scale. The firm emphasizes tech-enabled services and digital health solutions that address efficiencies and outcomes in healthcare delivery and patient care.

First In is a venture capital firm established in 2020 and located in Nashville, Tennessee. The firm focuses on investing in companies that tackle significant opportunities and challenges faced by commercial and government enterprises due to the exponential growth of data. First In primarily targets firms that specialize in data and security, seeking to support innovative solutions from inception to seed stage. By concentrating on modern security technologies, First In aims to enhance both enterprise operations and societal safety.

Rubicon Founders is an entrepreneurial firm established in 2021 and based in Nashville, Tennessee. The company is dedicated to building and growing transformational companies, primarily focusing on the healthcare sector. As a Registered Investment Adviser, Rubicon Founders aims to identify and invest in innovative opportunities within this industry, leveraging its expertise to support the development of impactful businesses.

Brickyard is a venture capital firm based in Chattanooga, Tennessee, founded in 2021. It provides early-stage capital and acts as a founder outpost that supports builders creating new technology. The firm targets pre-seed and seed-stage investments, with a focus on healthcare technology, and works with founders from around the world within a collaborative community that helps them pursue product-market fit.

Project Voice Capital Partners is a venture capital firm founded in 2022 and based in Nashville, Tennessee. It focuses on investing in early-stage artificial intelligence and voice technology startups, seeking to back top-tier entrepreneurs and building companies at the forefront of AI-enabled voice applications.

Founded in 2023 and headquartered in Nashville, Tennessee, Blue Hour Ventures is a venture capital firm focused on investing in early-stage companies driving innovation within America's healthcare system.

Elsewhere Partners is a venture capital firm investing in growth-stage B2B software companies headquartered outside traditional VC hubs, focusing on cities like Austin, Atlanta, and Toronto. They typically invest in companies generating at least $4 million in run rate revenue with at least 40% growth, having raised less than $10 million previously.

Jumpstart Health Investors, founded in 2013 and based in Nashville, Tennessee, is a venture capital firm focused on investing in the healthcare and wellness sectors. The company employs a systematic approach to private equity healthcare investing, aiming to create opportunities for investors while addressing critical factors such as access, risk mitigation, diversification, and portfolio management. By offering a family of funds tailored to various investor profiles and risk appetites, Jumpstart Health Investors seeks to facilitate strategic investments that contribute to advancements in healthcare.

Founded in 2013, Powered Health is a venture capital firm based in Nashville, Tennessee. It focuses on investing in healthcare technology startups.

Caduceus Capital Partners is a Nashville-based venture capital firm focused on early-stage digital health investments. Founded in 2020, it backs companies that leverage digitization to enable new care delivery models and drive innovation in health care, supporting ventures that address emerging needs in digital health through technology and services that improve patient outcomes and care efficiency.

77 Ventures is a principal investment firm located in New York, with an additional office in Nashville, Tennessee. Specializing in venture capital, the firm focuses on identifying and investing in innovative startups and emerging companies. As a boutique team, 77 Ventures aims to provide tailored support and resources to its portfolio companies, fostering growth and development in various industries. The firm is committed to building strong partnerships with entrepreneurs and supporting their visions for success.

Founded in 2021, Mark Two Ventures is a venture studio based in Nashville, Tennessee. It invests in early-stage technology startups operating in sectors such as SaaS and artificial intelligence across the Southeast region.

Solidus Company is an early-stage venture capital firm that invests in growth-stage companies.