MB Venture Partners

Lineus Medical is a medical device company that develops devices to prevent intravenous (IV) mechanical complications and improve vascular access outcomes. Its SafeBreak Vascular device uses break-away technology to create a controlled separation in IV tubing when excessive tension is applied, helping prevent dislodgement of peripheral IV lines, blood loss, and associated infections. The company designs a break-away IV therapy device compatible with a range of medical tubing, with the goal of enhancing safety and quality of care during IV therapy by reducing tubing-related disruptions and complications.

SweetBio, Inc. is a medical device company focused on the research, development, and manufacturing of innovative wound care solutions. Established in 2015 and headquartered in Memphis, Tennessee, SweetBio specializes in bioengineering membranes that incorporate medical-grade Manuka honey, which aids in healing and combating bacterial infections associated with various types of wounds, including surgical wounds, pressure ulcers, and diabetic ulcers. The company aims to revolutionize wound care by offering absorbable membranes that enhance the efficacy of treatments for both chronic and acute wounds, thereby improving patient outcomes for medical practitioners.

Founded in 2015, Cast21 specializes in developing innovative medical orthopedic products. Its flagship product is a waterproof and breathable cast designed for fracture and joint care, allowing patients to maintain hygiene without compromising healing. The company's unique design also accommodates electronic therapies to potentially reduce recovery time.

Spine Wave, Inc. is a medical device company that specializes in the development and marketing of innovative solutions for spinal disorders. Founded in 2001 and based in Shelton, Connecticut, the company offers a diverse range of products including expandable PEEK spacers, interbody devices for posterior surgery, and lateral stabilization systems. Its offerings also encompass the GraftMag Graft Delivery System for large bone graft delivery, fixation products for treating thoracolumbar spine conditions, and anterior cervical plate systems for spinal fusion. Spine Wave prioritizes a surgeon-driven product development approach, enabling it to create a differentiated portfolio of less invasive and efficient surgical solutions aimed at restoring spinal function and improving patients' quality of life. The company's products are distributed through various channels, ensuring wide accessibility for spine surgeons and their patients.

Lineus Medical is a medical device company that develops devices to prevent intravenous (IV) mechanical complications and improve vascular access outcomes. Its SafeBreak Vascular device uses break-away technology to create a controlled separation in IV tubing when excessive tension is applied, helping prevent dislodgement of peripheral IV lines, blood loss, and associated infections. The company designs a break-away IV therapy device compatible with a range of medical tubing, with the goal of enhancing safety and quality of care during IV therapy by reducing tubing-related disruptions and complications.

SweetBio, Inc. is a medical device company focused on the research, development, and manufacturing of innovative wound care solutions. Established in 2015 and headquartered in Memphis, Tennessee, SweetBio specializes in bioengineering membranes that incorporate medical-grade Manuka honey, which aids in healing and combating bacterial infections associated with various types of wounds, including surgical wounds, pressure ulcers, and diabetic ulcers. The company aims to revolutionize wound care by offering absorbable membranes that enhance the efficacy of treatments for both chronic and acute wounds, thereby improving patient outcomes for medical practitioners.

Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Founded in 2006, the company develops innovative diagnostic technology solutions for assessing spinal health. Its flagship product, the KineGraph Vertebral Motion Analyzer, employs fluoroscopy to capture spine motion and produce detailed patient-specific graphs that assist clinicians in diagnosing spinal instability and related conditions. In addition to its diagnostic devices, Ortho Kinematics offers comprehensive spine diagnostic imaging services through its imaging center in Austin, providing valuable information to healthcare professionals for the effective treatment of back and neck pain.

Restore Medical Solutions, Inc., established in 2012 and based in Memphis, Tennessee, specializes in manufacturing modular sterilization tray systems for hospitals and surgery centers. Their products aim to reduce surgical site infections (SSIs), enhance safety, and improve productivity within the healthcare industry by minimizing the risk of contamination from medical instruments.

Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Founded in 2006, the company develops innovative diagnostic technology solutions for assessing spinal health. Its flagship product, the KineGraph Vertebral Motion Analyzer, employs fluoroscopy to capture spine motion and produce detailed patient-specific graphs that assist clinicians in diagnosing spinal instability and related conditions. In addition to its diagnostic devices, Ortho Kinematics offers comprehensive spine diagnostic imaging services through its imaging center in Austin, providing valuable information to healthcare professionals for the effective treatment of back and neck pain.

Better Walk Inc. is an innovative company based in Atlanta, Georgia, specializing in the design and development of crutches. Founded in 2013, the company aims to enhance the traditional crutch design by alleviating pressure from the underarm area and minimizing direct force on the wrist of users. The organization emphasizes continuous innovation, recognizing the need for advancements in even the most established technologies. Better Walk gained early support through the Zero To 510 accelerator program in Memphis, Tennessee, which facilitated its initial funding. Since relocating to Atlanta in late 2014, the company has focused on refining its flagship product, the Better Walk crutch, and is preparing for its production and launch.

EndoInSight is a company focused on addressing the significant impact of colorectal cancer by offering a disposable insufflation system that enhances the comfort of patients undergoing colonoscopy-based screenings. The system utilizes carbon dioxide to inflate the colon, a method known to alleviate post-procedural pain and discomfort that often follows traditional air insufflation. Despite the recognized benefits of using carbon dioxide, its adoption in clinical settings has been limited due to a lack of awareness and the costs associated with existing CO2 insufflation systems. By providing a cost-effective solution, EndoInSight aims to improve patient outcomes and increase the acceptance of this more comfortable approach to colorectal cancer screening among healthcare professionals.

CrossRoads Extremity Systems, LLC is a medical device manufacturing company based in Memphis, Tennessee, specializing in implant systems for foot and ankle surgery. Founded in 2014, the company designs, manufactures, and markets a variety of surgical implants, including the MotoBAND CP Plating System for midfoot and forefoot procedures, the STRoPP implant kit, and the MotoCLIP which provides elastic fixation for healing bones. Additionally, CrossRoads produces the CrossTIE PIP Implant for hammertoe correction, various CrossTIE implant configurations for revision cases, and EcoSMART, an instrument recovery service. The company also develops Allograft wedges for consistent surgical handling, DBM putties, and advanced systems like DynaFORCE and Keel-Lock for enhanced surgical outcomes. CrossRoads Extremity Systems distributes its products through various partners in the United States, aimed at improving the operating room experience and achieving better patient outcomes.

Zyga Technology, Inc. is a medical device company focused on the research, design, development, and commercialization of minimally invasive products aimed at addressing underserved conditions of the lumbar spine. Founded in 2008 and headquartered in Minnetonka, Minnesota, the company offers the SImmetry Sacroiliac Joint Fusion System, which provides a surgical solution for sacroiliac joint fusion in patients with conditions such as sacroiliac joint disruptions and degenerative sacroiliitis. Additionally, Zyga is developing the Glyder Facet Restoration System, an investigational device intended to treat chronic facetogenic pain. The company is supported by a team of experienced engineers, marketing personnel, and management dedicated to advancing medical devices in the spine industry. Zyga Technology operates as a subsidiary of RTI Surgical, Inc.

EcoSurg is a developer of environmentally friendly surgical supplies focused on reducing the carbon footprint of the surgical suite. Its flagship product line comprises disposable foam patient positioners used to safely position patients in various surgical positions, ensuring safety, comfort, and access to the surgical site. These positioners are designed to minimize environmental impact compared with traditional petroleum-based materials, addressing hazardous byproducts and disposal costs associated with disposable medical supplies. The company emphasizes sustainability in its products, with design aimed at delivering a net-zero carbon footprint across the product lifecycle.

Blood Monitoring Solutions, Inc. is a Memphis, Tennessee-based company that specializes in developing innovative blood monitoring systems aimed at reducing blood wastage. The company has created a smart blood transport system that enables blood banks to proactively monitor the temperature and presence of each blood unit. This data-driven technology ensures that blood is maintained within the correct temperature range, thereby preventing spoilage and enhancing patient safety. By improving the management of blood supplies, Blood Monitoring Solutions not only helps hospitals preserve blood for longer periods but also contributes to cost reductions in healthcare settings.

Compression Kinetics, Inc., based in Memphis, Tennessee, specializes in the design and development of innovative medical devices, particularly advanced compression sleeves. These devices utilize shape memory alloy to generate a pressure wave that enhances circulation, reduces peripheral edema, and helps prevent blood clots. The company is at the forefront of wearable technology, transforming clinically proven compression therapy into sleek and affordable solutions. By improving recovery times and athletic performance, Compression Kinetics aims to provide athletes with the tools to enhance their performance, making high-quality compression therapy accessible to a broader audience within the growing athletic compression apparel market.

Innometrix, Inc. is a Memphis, Tennessee-based company focused on developing innovative technologies to address female pelvic floor disorders. By translating the science of biomechanics into clinical applications, Innometrix aims to provide physicians with enhanced diagnostic tools that create a biomechanical snapshot of the pelvic floor. This technology is designed to improve pre-surgical data, ultimately leading to better treatment outcomes and increased patient satisfaction. Female pelvic floor disorders are prevalent, affecting approximately 50% of women who have given birth, and current treatment methods often involve surgical procedures with high complication and revision rates. Innometrix seeks to revolutionize the diagnosis and treatment of these conditions by offering device solutions that alleviate challenges faced by clinicians, thereby contributing to a critical area in women's health that requires significant innovation.

CamPlex is a healthcare-focused company based in Germantown, Tennessee, founded in 2012. The company specializes in the manufacturing of high-quality fiber optic products designed to enhance performance and extend signal transmission infrastructure. CamPlex offers innovative fiber optic-based camera adapter systems and broadcast-grade interface gear, which facilitate easier and more efficient signal delivery for broadcast professionals. By providing these advanced solutions, CamPlex helps reduce operating costs by minimizing the need for additional components and costly replacements, thereby streamlining broadcasting operations.

Tidal Wave Technology manufactures a device to achieve a circumferential ablation of the nerves that surround the renal artery. It allows for renal denervation without placing any ablative elements within the renal artery. The company was founded in 2011 and is based in Memphis, Tennessee.

Hubble Telemedical specializes in the early detection of systemic and debilitating diseases that can be identified through retinal examinations. The company focuses on various eye conditions, including diabetic retinopathy, macular degeneration, and glaucoma, as well as systemic diseases such as cardiovascular and immune disorders. Hubble's proprietary Telemedical Retinal Image Analysis and Diagnosis (TRIAD) technology allows for real-time diagnosis of these conditions using readily available retinal cameras, making the screening process more accessible and convenient for patients. By partnering with healthcare providers, insurance companies, and employers, Hubble aims to improve annual retinal screening compliance, ultimately enhancing patient health outcomes and reducing overall healthcare costs. Their services are designed to be user-friendly, secure, and compliant with privacy regulations, and clinical studies have shown their effectiveness in increasing screening rates.

Restore Medical Solutions, Inc., established in 2012 and based in Memphis, Tennessee, specializes in manufacturing modular sterilization tray systems for hospitals and surgery centers. Their products aim to reduce surgical site infections (SSIs), enhance safety, and improve productivity within the healthcare industry by minimizing the risk of contamination from medical instruments.

Mobilizer Inc. is a company focused on enhancing medical ambulation through its innovative design of a six-wheeled holster for medical equipment. Modeled after a wheeled walker, this holster features shelves and attachments that facilitate the safe and efficient transport of equipment for critical care patients. By streamlining the ambulation process, Mobilizer aims to improve patient well-being and increase operational efficiency within healthcare settings. The company emerged from the ZeroTo510 medical device startup accelerator, reflecting its commitment to advancing medical technology solutions.

Hapten Sciences, Inc. is a biopharmaceutical company based in Memphis, Tennessee, founded in 2010. The company focuses on the identification and development of early-stage medical products aimed at enhancing health and well-being. One of its notable products is PDC-APB, a vaccine designed to prevent contact dermatitis resulting from exposure to urushiol oil found in poison ivy, poison oak, and poison sumac. This innovative approach enables patients to avoid allergic reactions without experiencing side effects, positioning Hapten Sciences as a significant contributor to advancements in dermatological health.

iScreen Vision develops and provides portable pediatric vision screening equipment using photoscreening technology. Its solution helps detect common childhood vision issues early, preventing potential serious problems like amblyopia.

Focal Point Pharmaceuticals is a healthcare company focused on pharmaceutical businesses. It was incorporated in 2013 and is based in Memphis, Tennessee, United States.

BioNanovations is a medical device company based in the United States, specializing in the development of a handheld diagnostic platform that utilizes bionanotechnology to identify bacterial infections, specifically Staphylococcus infections. The company aims to significantly reduce the diagnostic time from the current 3-5 days to under 30 minutes, addressing the urgent need for timely diagnosis due to the potential severity of aggressive strains that can lead to serious health complications. The platform is designed to monitor various biological samples, including blood, sputum, urine, and cerebrospinal fluid, providing healthcare professionals with immediate access to diagnostic information. This innovation not only enhances patient care by improving diagnostic efficiency but also facilitates the transmission of epidemiological data, enabling better tracking of infection trends. BioNanovations targets hospitals, healthcare providers, and government agencies, ultimately striving to improve patient outcomes by reducing morbidity and mortality associated with bacterial infections.

Better Walk Inc. is an innovative company based in Atlanta, Georgia, specializing in the design and development of crutches. Founded in 2013, the company aims to enhance the traditional crutch design by alleviating pressure from the underarm area and minimizing direct force on the wrist of users. The organization emphasizes continuous innovation, recognizing the need for advancements in even the most established technologies. Better Walk gained early support through the Zero To 510 accelerator program in Memphis, Tennessee, which facilitated its initial funding. Since relocating to Atlanta in late 2014, the company has focused on refining its flagship product, the Better Walk crutch, and is preparing for its production and launch.

iScreen Vision develops and provides portable pediatric vision screening equipment using photoscreening technology. Its solution helps detect common childhood vision issues early, preventing potential serious problems like amblyopia.

Mobilizer Inc. is a company focused on enhancing medical ambulation through its innovative design of a six-wheeled holster for medical equipment. Modeled after a wheeled walker, this holster features shelves and attachments that facilitate the safe and efficient transport of equipment for critical care patients. By streamlining the ambulation process, Mobilizer aims to improve patient well-being and increase operational efficiency within healthcare settings. The company emerged from the ZeroTo510 medical device startup accelerator, reflecting its commitment to advancing medical technology solutions.

EcoSurg is a developer of environmentally friendly surgical supplies focused on reducing the carbon footprint of the surgical suite. Its flagship product line comprises disposable foam patient positioners used to safely position patients in various surgical positions, ensuring safety, comfort, and access to the surgical site. These positioners are designed to minimize environmental impact compared with traditional petroleum-based materials, addressing hazardous byproducts and disposal costs associated with disposable medical supplies. The company emphasizes sustainability in its products, with design aimed at delivering a net-zero carbon footprint across the product lifecycle.

Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Founded in 2006, the company develops innovative diagnostic technology solutions for assessing spinal health. Its flagship product, the KineGraph Vertebral Motion Analyzer, employs fluoroscopy to capture spine motion and produce detailed patient-specific graphs that assist clinicians in diagnosing spinal instability and related conditions. In addition to its diagnostic devices, Ortho Kinematics offers comprehensive spine diagnostic imaging services through its imaging center in Austin, providing valuable information to healthcare professionals for the effective treatment of back and neck pain.

Hapten Sciences, Inc. is a biopharmaceutical company based in Memphis, Tennessee, founded in 2010. The company focuses on the identification and development of early-stage medical products aimed at enhancing health and well-being. One of its notable products is PDC-APB, a vaccine designed to prevent contact dermatitis resulting from exposure to urushiol oil found in poison ivy, poison oak, and poison sumac. This innovative approach enables patients to avoid allergic reactions without experiencing side effects, positioning Hapten Sciences as a significant contributor to advancements in dermatological health.

Hubble Telemedical specializes in the early detection of systemic and debilitating diseases that can be identified through retinal examinations. The company focuses on various eye conditions, including diabetic retinopathy, macular degeneration, and glaucoma, as well as systemic diseases such as cardiovascular and immune disorders. Hubble's proprietary Telemedical Retinal Image Analysis and Diagnosis (TRIAD) technology allows for real-time diagnosis of these conditions using readily available retinal cameras, making the screening process more accessible and convenient for patients. By partnering with healthcare providers, insurance companies, and employers, Hubble aims to improve annual retinal screening compliance, ultimately enhancing patient health outcomes and reducing overall healthcare costs. Their services are designed to be user-friendly, secure, and compliant with privacy regulations, and clinical studies have shown their effectiveness in increasing screening rates.

Cuff-Mate skin barriers offer healthcare professionals a cost-effective way to protect their patients, themselves and equipment when taking vital signs.

Although it is still relatively new, AIS, having a relationship with other biology-inspired computing models, and computational biology.

Health & Bliss Inc. is a medical device company based in Memphis, Tennessee, specializing in the design, patenting, and sale of innovative medical products and diagnostic tests. The company has developed Strep Test Anywhere, a point-of-care device that enables testing for multiple infections, including strep throat, influenza A/B, chlamydia, gonorrhea, and several others, directly at the patient's location. This technology aims to eliminate barriers to effective healthcare by providing rapid and affordable testing solutions, ensuring accurate results without the need for a doctor's visit. By addressing key concerns such as time and cost, Health & Bliss seeks to empower patients and healthcare providers alike.

SurgiLight offers a surgical lighting system that provides surgeons with a practical illumination device, enabling them to focus on target areas.

Better Walk Inc. is an innovative company based in Atlanta, Georgia, specializing in the design and development of crutches. Founded in 2013, the company aims to enhance the traditional crutch design by alleviating pressure from the underarm area and minimizing direct force on the wrist of users. The organization emphasizes continuous innovation, recognizing the need for advancements in even the most established technologies. Better Walk gained early support through the Zero To 510 accelerator program in Memphis, Tennessee, which facilitated its initial funding. Since relocating to Atlanta in late 2014, the company has focused on refining its flagship product, the Better Walk crutch, and is preparing for its production and launch.

Mobilizer Inc. is a company focused on enhancing medical ambulation through its innovative design of a six-wheeled holster for medical equipment. Modeled after a wheeled walker, this holster features shelves and attachments that facilitate the safe and efficient transport of equipment for critical care patients. By streamlining the ambulation process, Mobilizer aims to improve patient well-being and increase operational efficiency within healthcare settings. The company emerged from the ZeroTo510 medical device startup accelerator, reflecting its commitment to advancing medical technology solutions.

Spinal Restoration, Inc. is a company focused on developing innovative, minimally invasive therapies for chronic low back pain. Established in 2004 and headquartered in New York, it specializes in the Biostat System, a proprietary resorbable biologic compound and delivery system aimed at treating chronic discogenic pain caused by internal disc disruptions. The Biostat System comprises BIOSTAT BIOLOGX Fibrin Sealant, a resorbable biologic tissue sealant, and a proprietary delivery device designed to administer the biologic directly to the intervertebral disc. This targeted approach addresses a significant patient population, as chronic disc pain affects approximately four million adults annually.

Tidal Wave Technology manufactures a device to achieve a circumferential ablation of the nerves that surround the renal artery. It allows for renal denervation without placing any ablative elements within the renal artery. The company was founded in 2011 and is based in Memphis, Tennessee.

AxioMed LLC is a medical device company based in Malden, Massachusetts, specializing in the design and development of disc replacement devices aimed at alleviating neck pain and restoring normal spinal function for patients suffering from degenerative disc disease. Founded in 2001, the company was previously known as AxioMed Spine Corporation and rebranded in November 2014. AxioMed has developed the Freedom® Lumbar Disc and is also working on a project for cervical disc replacement. The company emphasizes advancing the standard of care beyond traditional fusion techniques and first-generation artificial discs. Guided by CEO Patrick McBrayer and COO James Kuras, AxioMed boasts a team with significant expertise in spinal implants, complemented by a Medical Advisory Panel of surgeons from leading spine centers and universities. The company's facilities encompass product development, testing, clinical and regulatory affairs, and manufacturing.

Restore Medical Solutions, Inc., established in 2012 and based in Memphis, Tennessee, specializes in manufacturing modular sterilization tray systems for hospitals and surgery centers. Their products aim to reduce surgical site infections (SSIs), enhance safety, and improve productivity within the healthcare industry by minimizing the risk of contamination from medical instruments.

Hubble Telemedical specializes in the early detection of systemic and debilitating diseases that can be identified through retinal examinations. The company focuses on various eye conditions, including diabetic retinopathy, macular degeneration, and glaucoma, as well as systemic diseases such as cardiovascular and immune disorders. Hubble's proprietary Telemedical Retinal Image Analysis and Diagnosis (TRIAD) technology allows for real-time diagnosis of these conditions using readily available retinal cameras, making the screening process more accessible and convenient for patients. By partnering with healthcare providers, insurance companies, and employers, Hubble aims to improve annual retinal screening compliance, ultimately enhancing patient health outcomes and reducing overall healthcare costs. Their services are designed to be user-friendly, secure, and compliant with privacy regulations, and clinical studies have shown their effectiveness in increasing screening rates.

Spinal Restoration, Inc. is a company focused on developing innovative, minimally invasive therapies for chronic low back pain. Established in 2004 and headquartered in New York, it specializes in the Biostat System, a proprietary resorbable biologic compound and delivery system aimed at treating chronic discogenic pain caused by internal disc disruptions. The Biostat System comprises BIOSTAT BIOLOGX Fibrin Sealant, a resorbable biologic tissue sealant, and a proprietary delivery device designed to administer the biologic directly to the intervertebral disc. This targeted approach addresses a significant patient population, as chronic disc pain affects approximately four million adults annually.

EcoSurg is a developer of environmentally friendly surgical supplies focused on reducing the carbon footprint of the surgical suite. Its flagship product line comprises disposable foam patient positioners used to safely position patients in various surgical positions, ensuring safety, comfort, and access to the surgical site. These positioners are designed to minimize environmental impact compared with traditional petroleum-based materials, addressing hazardous byproducts and disposal costs associated with disposable medical supplies. The company emphasizes sustainability in its products, with design aimed at delivering a net-zero carbon footprint across the product lifecycle.

Tidal Wave Technology manufactures a device to achieve a circumferential ablation of the nerves that surround the renal artery. It allows for renal denervation without placing any ablative elements within the renal artery. The company was founded in 2011 and is based in Memphis, Tennessee.

Urova Medical Inc. is a urological device company based in Memphis, Tennessee, focused on developing innovative solutions to address stress urinary incontinence in women. Founded in 2012, the company emerged from a project by undergraduate biomedical engineers at Johns Hopkins University, where its technology was refined with guidance from leading physicians at one of the top urological centers in the United States. Urova Medical collaborates with urologists, gynecologists, and clinical researchers to create effective and safe treatments for this condition. The company has also participated in the Zeroto510 Accelerator program, which supports health-focused startups in the region.

Nanophthalmics is a company focused on developing innovative surgical devices and techniques aimed at improving treatment outcomes for ophthalmic and other microsurgical diseases. They have created a patent-pending platform technology for microfabricated instruments that interact with tissue in novel ways. Their first commercial product is a disposable corneal micro-punch, which is 510(k) exempt and designed to promote healing for corneal abrasions, recurrent erosions, and various corneal diseases by modifying tissue attachments at the cellular level. Through their advancements, Nanophthalmics seeks to enhance the efficacy of surgical interventions in the eye care sector.

BioNanovations is a medical device company based in the United States, specializing in the development of a handheld diagnostic platform that utilizes bionanotechnology to identify bacterial infections, specifically Staphylococcus infections. The company aims to significantly reduce the diagnostic time from the current 3-5 days to under 30 minutes, addressing the urgent need for timely diagnosis due to the potential severity of aggressive strains that can lead to serious health complications. The platform is designed to monitor various biological samples, including blood, sputum, urine, and cerebrospinal fluid, providing healthcare professionals with immediate access to diagnostic information. This innovation not only enhances patient care by improving diagnostic efficiency but also facilitates the transmission of epidemiological data, enabling better tracking of infection trends. BioNanovations targets hospitals, healthcare providers, and government agencies, ultimately striving to improve patient outcomes by reducing morbidity and mortality associated with bacterial infections.

Restore Medical Solutions, Inc., established in 2012 and based in Memphis, Tennessee, specializes in manufacturing modular sterilization tray systems for hospitals and surgery centers. Their products aim to reduce surgical site infections (SSIs), enhance safety, and improve productivity within the healthcare industry by minimizing the risk of contamination from medical instruments.

HandMinder is a company focused on enhancing rehabilitation for stroke survivors suffering from hand dysfunction, a condition affecting approximately 60% of the 7 million stroke survivors in the United States. The company has developed a portable hand rehabilitation device that utilizes patent-pending vibration-guided brain engagement technology. This innovative approach aims to strengthen the neural connections between the hand and brain, resulting in significant improvements in hand function. Unlike traditional rehabilitation methods, which often require a passive role from the patient and can be costly, HandMinder's device promotes active engagement, leading to twice the improvement in hand movement and 2.5 times better quality of movement. The device is designed to be affordable and convenient, making it suitable for use in both clinical and home settings, thereby addressing the growing need for effective rehabilitation solutions for stroke victims.

S2 Interactive, Inc. is a Delaware C corp. founded by Larry Foster, R.N., in September, 2011. After working as a surgical nurse and spending 26 years in leadership roles within sales, marketing and professional education in the orthopedic & spine industry, Larry was convinced there was an opportunity to teach hospital staff to learn and manage surgical instruments more efficiently and safely. Larry spent five years working with technology experts realizing with the current trends in healthcare there was a clear need to increase hospital staff productivity/efficiency while driving cost savings. Larry’s vision combined with the introduction of user-friendly “hand held” technology platforms (tablets) enabled S2 Interactive to develop Virtual Back Table and Tray Touch software platforms. In September, 2011 additional funding was provided by 2 Memphis based venture capital organizations, Innova & MB Ventures. They are proud to be working with market leading companies in Medical Devices and many of the nation’s most prominent hospitals. Their technology has been used by over 1,000 different users in a variety of surgical specialties including cardiology, orthopedics, spine , general surgery and trauma.

Hapten Sciences, Inc. is a biopharmaceutical company based in Memphis, Tennessee, founded in 2010. The company focuses on the identification and development of early-stage medical products aimed at enhancing health and well-being. One of its notable products is PDC-APB, a vaccine designed to prevent contact dermatitis resulting from exposure to urushiol oil found in poison ivy, poison oak, and poison sumac. This innovative approach enables patients to avoid allergic reactions without experiencing side effects, positioning Hapten Sciences as a significant contributor to advancements in dermatological health.

Hubble Telemedical specializes in the early detection of systemic and debilitating diseases that can be identified through retinal examinations. The company focuses on various eye conditions, including diabetic retinopathy, macular degeneration, and glaucoma, as well as systemic diseases such as cardiovascular and immune disorders. Hubble's proprietary Telemedical Retinal Image Analysis and Diagnosis (TRIAD) technology allows for real-time diagnosis of these conditions using readily available retinal cameras, making the screening process more accessible and convenient for patients. By partnering with healthcare providers, insurance companies, and employers, Hubble aims to improve annual retinal screening compliance, ultimately enhancing patient health outcomes and reducing overall healthcare costs. Their services are designed to be user-friendly, secure, and compliant with privacy regulations, and clinical studies have shown their effectiveness in increasing screening rates.

Urova Medical Inc. is a urological device company based in Memphis, Tennessee, focused on developing innovative solutions to address stress urinary incontinence in women. Founded in 2012, the company emerged from a project by undergraduate biomedical engineers at Johns Hopkins University, where its technology was refined with guidance from leading physicians at one of the top urological centers in the United States. Urova Medical collaborates with urologists, gynecologists, and clinical researchers to create effective and safe treatments for this condition. The company has also participated in the Zeroto510 Accelerator program, which supports health-focused startups in the region.

EcoSurg is a developer of environmentally friendly surgical supplies focused on reducing the carbon footprint of the surgical suite. Its flagship product line comprises disposable foam patient positioners used to safely position patients in various surgical positions, ensuring safety, comfort, and access to the surgical site. These positioners are designed to minimize environmental impact compared with traditional petroleum-based materials, addressing hazardous byproducts and disposal costs associated with disposable medical supplies. The company emphasizes sustainability in its products, with design aimed at delivering a net-zero carbon footprint across the product lifecycle.

Zyga Technology, Inc. is a medical device company focused on the research, design, development, and commercialization of minimally invasive products aimed at addressing underserved conditions of the lumbar spine. Founded in 2008 and headquartered in Minnetonka, Minnesota, the company offers the SImmetry Sacroiliac Joint Fusion System, which provides a surgical solution for sacroiliac joint fusion in patients with conditions such as sacroiliac joint disruptions and degenerative sacroiliitis. Additionally, Zyga is developing the Glyder Facet Restoration System, an investigational device intended to treat chronic facetogenic pain. The company is supported by a team of experienced engineers, marketing personnel, and management dedicated to advancing medical devices in the spine industry. Zyga Technology operates as a subsidiary of RTI Surgical, Inc.

Tidal Wave Technology manufactures a device to achieve a circumferential ablation of the nerves that surround the renal artery. It allows for renal denervation without placing any ablative elements within the renal artery. The company was founded in 2011 and is based in Memphis, Tennessee.

Veracity Medical Solutions, established in 2007 and headquartered in Collierville, Tennessee, is a medical device manufacturing company. It operates as a subsidiary of Arcamed, LLC. Veracity specializes in contract manufacturing, offering a comprehensive range of services from raw material to finished, packaged products. These services include design, development, prototyping, customization, and specials, ensuring clients can efficiently and accurately produce surgical instrumentation and implants.

Cayenne Medical, Inc. is a medical device company based in Scottsdale, Arizona, specializing in soft tissue reconstruction solutions for the knee, shoulder, and extremities. Founded in 2005, the company designs and develops a range of products for arthroscopic surgery, including the AperFix System, which facilitates anterior cruciate ligament (ACL) reconstruction using various grafts. Its offerings also include the AperFix Femoral and Tibial devices for restoring knee kinematics and anatomical reconstruction. Additionally, Cayenne Medical provides the CrossFix II System for meniscal repair, the iFix Interference Screw System for ACL procedures, and a line of shoulder products under the Quattro System for various soft tissue repairs. The company's innovative solutions aim to enhance surgical precision and improve patient outcomes in sports medicine.

MB Innovations, Inc., founded in 2011 and based in Memphis, Tennessee, operates as a medical technology development company. It offers research, design, and development services for established firms on a fee-for-service basis, specializing in the musculoskeletal disease sector due to its strategic location near relevant R&D capabilities. The company's team of experienced engineers and surgeon advisors aims to accelerate product development and time-to-market for clients, providing comprehensive support from concept to first-in-man surgical procedures. Additionally, MB Innovations creates its own technologies and intellectual property to facilitate new venture formation and job creation within the region.

Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Founded in 2006, the company develops innovative diagnostic technology solutions for assessing spinal health. Its flagship product, the KineGraph Vertebral Motion Analyzer, employs fluoroscopy to capture spine motion and produce detailed patient-specific graphs that assist clinicians in diagnosing spinal instability and related conditions. In addition to its diagnostic devices, Ortho Kinematics offers comprehensive spine diagnostic imaging services through its imaging center in Austin, providing valuable information to healthcare professionals for the effective treatment of back and neck pain.

Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Founded in 2006, the company develops innovative diagnostic technology solutions for assessing spinal health. Its flagship product, the KineGraph Vertebral Motion Analyzer, employs fluoroscopy to capture spine motion and produce detailed patient-specific graphs that assist clinicians in diagnosing spinal instability and related conditions. In addition to its diagnostic devices, Ortho Kinematics offers comprehensive spine diagnostic imaging services through its imaging center in Austin, providing valuable information to healthcare professionals for the effective treatment of back and neck pain.

AxioMed LLC is a medical device company based in Malden, Massachusetts, specializing in the design and development of disc replacement devices aimed at alleviating neck pain and restoring normal spinal function for patients suffering from degenerative disc disease. Founded in 2001, the company was previously known as AxioMed Spine Corporation and rebranded in November 2014. AxioMed has developed the Freedom® Lumbar Disc and is also working on a project for cervical disc replacement. The company emphasizes advancing the standard of care beyond traditional fusion techniques and first-generation artificial discs. Guided by CEO Patrick McBrayer and COO James Kuras, AxioMed boasts a team with significant expertise in spinal implants, complemented by a Medical Advisory Panel of surgeons from leading spine centers and universities. The company's facilities encompass product development, testing, clinical and regulatory affairs, and manufacturing.

Anulex Technologies focus on developing proprietary medical technology to repair and seal the soft tissue of the spine (anulus) for patients undergoing a surgical procedure to remove a herniated disc (discectomy).

Calosyn Pharma specializes in developing innovative treatments for osteoarthritis. Its flagship product, CAL-05CR, is a sustained-release injectable therapy combining verapamil with a biodegradable delivery system. This treatment aims to provide long-lasting pain relief and reduce inflammation by targeting the underlying causes of osteoarthritis.

Anulex Technologies focus on developing proprietary medical technology to repair and seal the soft tissue of the spine (anulus) for patients undergoing a surgical procedure to remove a herniated disc (discectomy).

Visioneering Technologies, Inc., established in 2008 and based in Alpharetta, Georgia, is a medical device company specializing in the design, manufacture, and distribution of contact lenses. The company's flagship product, NaturalVue, is a multifocal contact lens designed to address presbyopia in adults and myopia in children. Visioneering Technologies operates in North America, Europe, and the Asia Pacific region, with a mission to enhance practitioner and patient experiences through innovative and differentiated optical solutions. The company holds fourteen issued patents worldwide, reflecting its commitment to advancing eye care.

BrainsGate is a medical device company that develops therapies for central nervous system diseases, focusing on acute ischemic stroke. Its platform uses electrical stimulation of the spheno‑palatine ganglion (SPG) via a miniature electrode implanted in the roof of the mouth. The procedure is minimally invasive, performed at bedside under local anesthesia, and is designed to increase cerebral blood flow. The company has completed several clinical studies, including the ImPACT‑1 pilot, a 300‑patient randomized controlled trial, and is currently conducting the ImpACT‑24b pivotal study. Founded in 2000, BrainsGate is headquartered in Caesarea, Israel.

Protein Discovery is a life sciences company based in Knoxville, Tennessee, focused on developing and commercializing sample preparation technologies for protein and peptide analysis using mass spectrometry. The company offers several key products: the Gelfree 8100 fractionation system, which separates complex protein mixtures into liquid-phase molecular weight fractions; the Passport 1200 sample preparation system, designed to enrich low molecular weight proteins and peptides while removing matrix interferences for high-throughput quantification applications; and PPS Silent Surfactant, a reagent that solubilizes membrane proteins and cleaves to eliminate detergent interference. Additionally, Protein Discovery provides the UPX universal protein extraction kit for detergent extraction of proteins from cells and tissues. These products are marketed through Agilent Technologies and online, serving life science researchers and drug development scientists both domestically and internationally. Founded in 2001 as Qgenics Biosciences, Inc., the company rebranded to Protein Discovery, Inc. in April 2004.

Cayenne Medical, Inc. is a medical device company based in Scottsdale, Arizona, specializing in soft tissue reconstruction solutions for the knee, shoulder, and extremities. Founded in 2005, the company designs and develops a range of products for arthroscopic surgery, including the AperFix System, which facilitates anterior cruciate ligament (ACL) reconstruction using various grafts. Its offerings also include the AperFix Femoral and Tibial devices for restoring knee kinematics and anatomical reconstruction. Additionally, Cayenne Medical provides the CrossFix II System for meniscal repair, the iFix Interference Screw System for ACL procedures, and a line of shoulder products under the Quattro System for various soft tissue repairs. The company's innovative solutions aim to enhance surgical precision and improve patient outcomes in sports medicine.

Spinal Restoration, Inc. is a company focused on developing innovative, minimally invasive therapies for chronic low back pain. Established in 2004 and headquartered in New York, it specializes in the Biostat System, a proprietary resorbable biologic compound and delivery system aimed at treating chronic discogenic pain caused by internal disc disruptions. The Biostat System comprises BIOSTAT BIOLOGX Fibrin Sealant, a resorbable biologic tissue sealant, and a proprietary delivery device designed to administer the biologic directly to the intervertebral disc. This targeted approach addresses a significant patient population, as chronic disc pain affects approximately four million adults annually.

KFx Medical specializes in the development and manufacturing of advanced soft tissue fixation implants specifically designed for orthopedic sports medicine. The company creates innovative products that facilitate tissue fixation, allowing for direct placement into bone, with or without sutures. These implants are utilized in various orthopedic surgical procedures, enabling surgeons to effectively reattach tissue in areas such as the shoulder, knee, foot, and ankle. KFx Medical collaborates with leading orthopedic surgeons to refine its technology and enhance surgical outcomes for patients.

BioSET, Inc., founded in 2001 and based in Rockville, Maryland, specializes in the research and development of synthetic bioactive peptides aimed at enhancing bone and soft tissue repair. The company creates proprietary therapeutic peptides utilized as medical devices in orthobiologics applications. Its notable product, Amplex, is an implantable device that combines a peptide with a synthetic ceramic scaffold, designed for use in spinal fusion surgeries and other orthopedic procedures. Additionally, BioSET develops products for sports medicine and creates peptide signaling molecules along with various scaffold biomaterials for applications in trauma, fracture repair, and soft tissue treatments. As of February 2015, BioSET operates as a subsidiary of Ferring Pharmaceuticals Inc.

Applied Spine Technologies is a medical device company based in Wellesley, Massachusetts, specializing in the design and development of spine stabilization systems. The firm focuses on creating innovative solutions for patients with injured or degenerated spines, offering devices that provide support while preserving natural motion. One of its notable products is the Stabilimax Dynamic Spine Stabilization System, a posterior dynamic stabilization device that aims to enhance patient outcomes by maintaining spinal flexibility during treatment.

Cayenne Medical, Inc. is a medical device company based in Scottsdale, Arizona, specializing in soft tissue reconstruction solutions for the knee, shoulder, and extremities. Founded in 2005, the company designs and develops a range of products for arthroscopic surgery, including the AperFix System, which facilitates anterior cruciate ligament (ACL) reconstruction using various grafts. Its offerings also include the AperFix Femoral and Tibial devices for restoring knee kinematics and anatomical reconstruction. Additionally, Cayenne Medical provides the CrossFix II System for meniscal repair, the iFix Interference Screw System for ACL procedures, and a line of shoulder products under the Quattro System for various soft tissue repairs. The company's innovative solutions aim to enhance surgical precision and improve patient outcomes in sports medicine.

Anulex Technologies focus on developing proprietary medical technology to repair and seal the soft tissue of the spine (anulus) for patients undergoing a surgical procedure to remove a herniated disc (discectomy).

Kereos, Inc. is a biopharmaceutical company based in St. Louis, Missouri, specializing in the development of nanoscale drug delivery technologies and molecular imaging agents aimed at the detection and treatment of cancer and cardiovascular diseases. Founded in 1999, Kereos focuses on targeted delivery systems that enhance the effectiveness of therapeutic compounds, including existing drugs and novel candidates, particularly those that are too toxic or fragile for conventional delivery methods. The company's product portfolio includes KER-1001 and KER-1002, both cancer therapeutics utilizing natural products with demonstrated anti-tumor efficacy, and KER-1003, which targets angiogenesis. Additionally, Kereos offers diagnostic applications, such as KER 0001, an imaging platform for detecting angiogenesis. The company is also engaged in developing partnerships with pharmaceutical and imaging firms to advance its molecular imaging systems and cardiovascular disease MRI agents, thereby broadening its impact in the healthcare sector.

KFx Medical specializes in the development and manufacturing of advanced soft tissue fixation implants specifically designed for orthopedic sports medicine. The company creates innovative products that facilitate tissue fixation, allowing for direct placement into bone, with or without sutures. These implants are utilized in various orthopedic surgical procedures, enabling surgeons to effectively reattach tissue in areas such as the shoulder, knee, foot, and ankle. KFx Medical collaborates with leading orthopedic surgeons to refine its technology and enhance surgical outcomes for patients.

BrainsGate is a medical device company that develops therapies for central nervous system diseases, focusing on acute ischemic stroke. Its platform uses electrical stimulation of the spheno‑palatine ganglion (SPG) via a miniature electrode implanted in the roof of the mouth. The procedure is minimally invasive, performed at bedside under local anesthesia, and is designed to increase cerebral blood flow. The company has completed several clinical studies, including the ImPACT‑1 pilot, a 300‑patient randomized controlled trial, and is currently conducting the ImpACT‑24b pivotal study. Founded in 2000, BrainsGate is headquartered in Caesarea, Israel.

BioMimetic Therapeutics is a biotechnology company based in Franklin, Tennessee, founded in 1999. The company focuses on the development of biologically active drug-device combination products designed to stimulate the body's natural tissue regenerative processes. Its product portfolio includes Augment Injectable and Augment Rotator Cuff, which target various orthopedic and sports medicine conditions. These products are utilized for treating foot and ankle fusions, facilitating wrist fracture healing, and addressing surgical interventions for rotator cuff tears. Additionally, BioMimetic Therapeutics offers the Augment Tendinopathy Injection, aimed at managing injuries resulting from tendon overuse. The company is dedicated to advancing solutions for the healing of injuries and diseases affecting the skeleton and associated tissues.

AxioMed LLC is a medical device company based in Malden, Massachusetts, specializing in the design and development of disc replacement devices aimed at alleviating neck pain and restoring normal spinal function for patients suffering from degenerative disc disease. Founded in 2001, the company was previously known as AxioMed Spine Corporation and rebranded in November 2014. AxioMed has developed the Freedom® Lumbar Disc and is also working on a project for cervical disc replacement. The company emphasizes advancing the standard of care beyond traditional fusion techniques and first-generation artificial discs. Guided by CEO Patrick McBrayer and COO James Kuras, AxioMed boasts a team with significant expertise in spinal implants, complemented by a Medical Advisory Panel of surgeons from leading spine centers and universities. The company's facilities encompass product development, testing, clinical and regulatory affairs, and manufacturing.

BioMimetic Therapeutics is a biotechnology company based in Franklin, Tennessee, founded in 1999. The company focuses on the development of biologically active drug-device combination products designed to stimulate the body's natural tissue regenerative processes. Its product portfolio includes Augment Injectable and Augment Rotator Cuff, which target various orthopedic and sports medicine conditions. These products are utilized for treating foot and ankle fusions, facilitating wrist fracture healing, and addressing surgical interventions for rotator cuff tears. Additionally, BioMimetic Therapeutics offers the Augment Tendinopathy Injection, aimed at managing injuries resulting from tendon overuse. The company is dedicated to advancing solutions for the healing of injuries and diseases affecting the skeleton and associated tissues.

BioSET, Inc., founded in 2001 and based in Rockville, Maryland, specializes in the research and development of synthetic bioactive peptides aimed at enhancing bone and soft tissue repair. The company creates proprietary therapeutic peptides utilized as medical devices in orthobiologics applications. Its notable product, Amplex, is an implantable device that combines a peptide with a synthetic ceramic scaffold, designed for use in spinal fusion surgeries and other orthopedic procedures. Additionally, BioSET develops products for sports medicine and creates peptide signaling molecules along with various scaffold biomaterials for applications in trauma, fracture repair, and soft tissue treatments. As of February 2015, BioSET operates as a subsidiary of Ferring Pharmaceuticals Inc.

Alveolus is a pioneering company specializing in non-vascular interventional stenting technology, focusing on the development of advanced stents for pulmonary, gastrointestinal, and related medical applications. Its innovative technology aims to create artificial pathways and support structures in hollow lumen organs that have become obstructed or closed due to cancerous lesions or benign diseases. By providing healthcare professionals, such as interventional pulmonologists, gastroenterologists, and radiologists, with effective tools, Alveolus enhances treatment options for patients facing these medical challenges. The company's products address significant needs in interventional medicine, promoting improved patient outcomes through cutting-edge solutions.

Salient Surgical Technologies, Inc. is a privately held medical technology company, established in 1999, that specializes in the development and marketing of advanced energy devices for surgical applications. Initially focused on monopolar electrosurgical devices for treating liver cancers, the company has since expanded its product offerings with the AQUAMANTYS® System. This system employs patented TRANSCOLLATION® technology, which allows for the haemostatic sealing of soft tissue and bone, significantly reducing surgical blood loss. The AQUAMANTYS System, which includes a bipolar electrosurgical generator, pump system, and a range of handheld disposable devices, is utilized in various surgical fields such as orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's innovative products are distributed across the United States, Europe, and Asia, contributing to improved clinical outcomes and economic efficiencies for healthcare providers and patients alike. To date, over 500,000 patients have benefited from the use of TRANSCOLLATION technology.

GTx, Inc. was a biopharmaceutical company focused on the discovery, development, and commercialization of innovative treatments for stress urinary incontinence and prostate cancer. The company specialized in selective androgen receptor modulators (SARMs) and selective androgen receptor degraders. Its notable product candidate, enobosarm (GTx-024), was in Phase II clinical trials aimed at treating various forms of breast cancer and offering solutions for postmenopausal women with stress urinary incontinence. Founded in 1997 and based in Memphis, Tennessee, GTx aimed to improve patient outcomes through its targeted therapeutic approaches. In 2019, GTx was acquired by Oncternal Therapeutics, marking the completion of a reverse merger transaction.

BioMimetic Therapeutics is a biotechnology company based in Franklin, Tennessee, founded in 1999. The company focuses on the development of biologically active drug-device combination products designed to stimulate the body's natural tissue regenerative processes. Its product portfolio includes Augment Injectable and Augment Rotator Cuff, which target various orthopedic and sports medicine conditions. These products are utilized for treating foot and ankle fusions, facilitating wrist fracture healing, and addressing surgical interventions for rotator cuff tears. Additionally, BioMimetic Therapeutics offers the Augment Tendinopathy Injection, aimed at managing injuries resulting from tendon overuse. The company is dedicated to advancing solutions for the healing of injuries and diseases affecting the skeleton and associated tissues.

TriVirix International is a U.S.-based manufacturer specializing in the design and production of electro-mechanical medical devices, diagnostic instruments, and life-science equipment. Headquartered in Milaca, Minnesota, the company offers a range of products including ribo printers, point-of-care blood testing analyzers, volumetric infusion pumps, and monitors for vital signs and conscious sedation. TriVirix International focuses on delivering innovative solutions to meet the needs of healthcare providers and enhance patient care.