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Avedro, Inc. is a commercial-stage ophthalmic pharmaceutical and medical device company headquartered in Waltham, Massachusetts. The company specializes in developing and commercializing innovative products for treating corneal disorders, primarily focusing on corneal ectatic conditions and refractive issues. Avedro's proprietary Corneal Remodeling Platform includes the KXL and Mosaic systems, which utilize ultraviolet A (UVA) light in conjunction with riboflavin drug formulations for corneal cross-linking. This technology is aimed at strengthening and reshaping the cornea through minimally invasive and non-invasive outpatient procedures. Avedro has also introduced the Keraflex refractive correction procedure, a non-invasive technique for flattening the cornea without tissue removal. While Avedro primarily serves ophthalmologists, hospitals, and ambulatory surgery centers in the United States, it also markets its products internationally through medical device distributors. The company, originally named ThermalVision, Inc., was incorporated in 2002 and rebranded as Avedro in 2005. As of November 2019, Avedro operates as a subsidiary of Glaukos Corporation.

Avedro, Inc. is a commercial-stage ophthalmic pharmaceutical and medical device company headquartered in Waltham, Massachusetts. The company specializes in developing and commercializing innovative products for treating corneal disorders, primarily focusing on corneal ectatic conditions and refractive issues. Avedro's proprietary Corneal Remodeling Platform includes the KXL and Mosaic systems, which utilize ultraviolet A (UVA) light in conjunction with riboflavin drug formulations for corneal cross-linking. This technology is aimed at strengthening and reshaping the cornea through minimally invasive and non-invasive outpatient procedures. Avedro has also introduced the Keraflex refractive correction procedure, a non-invasive technique for flattening the cornea without tissue removal. While Avedro primarily serves ophthalmologists, hospitals, and ambulatory surgery centers in the United States, it also markets its products internationally through medical device distributors. The company, originally named ThermalVision, Inc., was incorporated in 2002 and rebranded as Avedro in 2005. As of November 2019, Avedro operates as a subsidiary of Glaukos Corporation.

TearScience, Inc. is a medical device company based in Morrisville, North Carolina, specializing in the identification, diagnosis, and treatment of meibomian gland disease (MGD), a primary cause of dry eye affecting millions worldwide. Founded in 2005, TearScience has developed innovative devices to address evaporative dry eye, including the LipiFlow Activator, which delivers automated therapeutic energies to treat the meibomian glands, and the LipiScan, an imaging tool that allows eye care professionals to assess gland health. The company's integrated system enables effective management of MGD, which is often underestimated despite being a leading contributor to dry eye symptoms such as irritation, dryness, and visual disturbances. As a subsidiary of Johnson & Johnson Surgical Vision, TearScience continues to advance its mission of improving patient outcomes through early detection and treatment of this chronic condition.

Benvenue Medical, Inc. is a company specializing in the design, manufacture, and marketing of minimally invasive expandable implant systems for the treatment of spinal disorders, specifically vertebral compression fractures and degenerative disc diseases. Its product offerings include the Kiva system, which addresses spinal fractures in the thoracic and lumbar regions, and the Blazer – C system, designed for treating pathological vertebral compression fractures. Additionally, Benvenue Medical has introduced the Luna 3D, an expandable interbody fusion system suitable for various surgical approaches. The company serves a diverse customer base across the United States, Canada, Belgium, France, and Germany. Founded in 2004, Benvenue Medical is headquartered in Santa Clara, California, and is focused on developing innovative surgical solutions that enhance patient outcomes and restore spinal alignment.

Benvenue Medical, Inc. is a company specializing in the design, manufacture, and marketing of minimally invasive expandable implant systems for the treatment of spinal disorders, specifically vertebral compression fractures and degenerative disc diseases. Its product offerings include the Kiva system, which addresses spinal fractures in the thoracic and lumbar regions, and the Blazer – C system, designed for treating pathological vertebral compression fractures. Additionally, Benvenue Medical has introduced the Luna 3D, an expandable interbody fusion system suitable for various surgical approaches. The company serves a diverse customer base across the United States, Canada, Belgium, France, and Germany. Founded in 2004, Benvenue Medical is headquartered in Santa Clara, California, and is focused on developing innovative surgical solutions that enhance patient outcomes and restore spinal alignment.

Spinal Kinetics LLC is a medical device company based in Sunnyvale, California, founded in 2003. The company specializes in the design and development of non-fusion motion preservation systems for treating degenerative diseases of the cervical and lumbar spine. Its flagship products, the M6-C and M6-L artificial discs, offer innovative options for artificial cervical and lumbar disc replacements, respectively. These discs are uniquely engineered to replicate the anatomical and biomechanical properties of natural intervertebral discs by incorporating an artificial nucleus and annulus. Spinal Kinetics collaborates with spine surgeons to enhance the effectiveness of its devices, which are distributed in various countries, including Australia, Germany, Spain, and the United Kingdom. The company operates as a subsidiary of Orthofix Medical Inc.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

MyoScience Inc., founded in 2005 and based in Redwood City, California, focuses on the development and commercialization of innovative dermatological products. The company leverages advanced technology to create solutions aimed at addressing various skin-related issues. Through its efforts, MyoScience aims to provide effective products that enhance skin health and appearance.

TRIA Beauty, Inc. is a developer and marketer of light-based medical devices aimed at the consumer market, specializing in beauty and skincare solutions. Founded in 2003 and headquartered in Dublin, California, the company offers a range of innovative products including a hand-held, cordless diode laser for hair removal, a Skin Perfecting Blue Light device for acne treatment, a Skin Rejuvenating Laser for anti-aging purposes, and an Age-Defying Eye Wrinkle Correcting Laser. These devices utilize advanced light technology, which is preferred by dermatologists for effective skincare treatments, allowing users to achieve professional results at home. TRIA Beauty products are available through its e-commerce platform and various indirect sales channels, including retail outlets, television, and physician offices. The company serves a global market, reaching customers in the United States, Japan, South Korea, Canada, the United Kingdom, Germany, and Spain.

Avedro, Inc. is a commercial-stage ophthalmic pharmaceutical and medical device company headquartered in Waltham, Massachusetts. The company specializes in developing and commercializing innovative products for treating corneal disorders, primarily focusing on corneal ectatic conditions and refractive issues. Avedro's proprietary Corneal Remodeling Platform includes the KXL and Mosaic systems, which utilize ultraviolet A (UVA) light in conjunction with riboflavin drug formulations for corneal cross-linking. This technology is aimed at strengthening and reshaping the cornea through minimally invasive and non-invasive outpatient procedures. Avedro has also introduced the Keraflex refractive correction procedure, a non-invasive technique for flattening the cornea without tissue removal. While Avedro primarily serves ophthalmologists, hospitals, and ambulatory surgery centers in the United States, it also markets its products internationally through medical device distributors. The company, originally named ThermalVision, Inc., was incorporated in 2002 and rebranded as Avedro in 2005. As of November 2019, Avedro operates as a subsidiary of Glaukos Corporation.

TRIA Beauty, Inc. is a developer and marketer of light-based medical devices aimed at the consumer market, specializing in beauty and skincare solutions. Founded in 2003 and headquartered in Dublin, California, the company offers a range of innovative products including a hand-held, cordless diode laser for hair removal, a Skin Perfecting Blue Light device for acne treatment, a Skin Rejuvenating Laser for anti-aging purposes, and an Age-Defying Eye Wrinkle Correcting Laser. These devices utilize advanced light technology, which is preferred by dermatologists for effective skincare treatments, allowing users to achieve professional results at home. TRIA Beauty products are available through its e-commerce platform and various indirect sales channels, including retail outlets, television, and physician offices. The company serves a global market, reaching customers in the United States, Japan, South Korea, Canada, the United Kingdom, Germany, and Spain.

Benvenue Medical, Inc. is a company specializing in the design, manufacture, and marketing of minimally invasive expandable implant systems for the treatment of spinal disorders, specifically vertebral compression fractures and degenerative disc diseases. Its product offerings include the Kiva system, which addresses spinal fractures in the thoracic and lumbar regions, and the Blazer – C system, designed for treating pathological vertebral compression fractures. Additionally, Benvenue Medical has introduced the Luna 3D, an expandable interbody fusion system suitable for various surgical approaches. The company serves a diverse customer base across the United States, Canada, Belgium, France, and Germany. Founded in 2004, Benvenue Medical is headquartered in Santa Clara, California, and is focused on developing innovative surgical solutions that enhance patient outcomes and restore spinal alignment.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

Astute Medical, Inc. is a life science tools company focused on improving the diagnosis of high-risk medical conditions through the discovery and development of protein biomarkers. Founded in 2007 and based in San Diego, California, with an additional location in Paris, France, the company specializes in creating novel diagnostic tests that enable rapid diagnosis and risk assessment for conditions such as abdominal pain, acute coronary syndromes, cerebrovascular injury, kidney injury, and sepsis. Astute Medical's flagship product, NephroCheck, is a single-use cartridge designed to detect biomarkers associated with acute kidney injury, while the Astute140 meter converts the test's fluorescent signal into a single numerical result. The company markets its products primarily in the United States and Europe and operates as a subsidiary of bioMérieux S.A.

WaveTec Vision, founded in 1997 and located in Aliso Viejo, California, specializes in advanced wavefront measurement technology for cataract surgery. The company's proprietary intraoperative aberrometer system, ORange, allows surgeons to measure the eye and enhance surgical outcomes in real-time. By facilitating the convergence of refractive and cataract surgery, WaveTec Vision aims to improve the overall efficacy and precision of these procedures, ultimately benefiting patient care and satisfaction.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

MyoScience Inc., founded in 2005 and based in Redwood City, California, focuses on the development and commercialization of innovative dermatological products. The company leverages advanced technology to create solutions aimed at addressing various skin-related issues. Through its efforts, MyoScience aims to provide effective products that enhance skin health and appearance.

Viracta Therapeutics, Inc. is a clinical-stage drug development company based in Cardiff, California, that specializes in precision oncology focused on virus-associated malignancies. The company utilizes a viral activation therapy platform to develop treatments for cancers linked to the Epstein-Barr Virus (EBV) and other virus-related diseases. Its lead investigational drug, nanatinostat, is being evaluated in combination with the antiviral valganciclovir as a potential oral therapy for EBV-positive lymphoma, including post-transplant lymphoproliferative disorder, plasmablastic lymphoma, and angioimmunoblastic T cell lymphoma. Viracta is also exploring the application of this approach to other EBV-associated conditions, such as nasopharyngeal carcinoma and gastric carcinoma. Founded in 2007 and rebranded from HemaQuest Pharmaceuticals in 2015, Viracta Therapeutics is actively conducting multiple clinical trials to advance its therapeutic candidates.

Pulmonx Corporation is a medical technology company specializing in minimally invasive solutions for the diagnosis and treatment of chronic obstructive pulmonary disease (COPD), particularly severe emphysema. Its primary offerings include the Zephyr Endobronchial Valve, designed for patients with hyperinflation due to emphysema, as well as the Chartis Pulmonary Assessment System, which assesses collateral ventilation, and the StratX Lung Analysis Platform, a cloud-based service that analyzes computed tomography data to identify suitable treatment areas. Pulmonx aims to improve the quality of life for patients who remain symptomatic despite medical management and may not be candidates for surgical interventions. The company has received FDA pre-market approval for the Zephyr Valve and has established a global presence, serving markets in the United States, Europe, the Middle East, Africa, and the Asia-Pacific region. Founded in 1995 and headquartered in Redwood City, California, Pulmonx has become a leader in interventional procedures for COPD, supported by extensive clinical evidence demonstrating the effectiveness of its technologies.

iScience Interventional specializes in developing innovative medical technologies for ophthalmic interventions. They focus on creating advanced microcatheters and imaging systems, enabling eye specialists to precisely administer therapies to specific locations within the eye. Additionally, they offer medical devices for canaloplasty procedures.

Simprica Spine is a stabilization system designed to stabilize the spine in flexion and helps patients rehabilitate better.

Spinal Modulation, Inc., headquartered in Menlo Park, California, specializes in the development of advanced medical devices aimed at treating chronic pain. The company's flagship product, the Axium Neurostimulator System, represents a novel approach to pain management through intraspinal neuromodulation. This system specifically stimulates the dorsal root ganglion (DRG), providing an innovative alternative for patients suffering from chronic intractable leg pain and other challenging pain conditions such as those affecting the back and foot. By effectively targeting the DRG, the Axium system offers the ability to deliver adjustable therapies that can be tailored to address both broad and localized pain areas, while minimizing discomfort associated with traditional spinal cord stimulators. This technology addresses a significant unmet need in pain management, aiming to alleviate the burden on patients and healthcare systems alike.

WaveTec Vision, founded in 1997 and located in Aliso Viejo, California, specializes in advanced wavefront measurement technology for cataract surgery. The company's proprietary intraoperative aberrometer system, ORange, allows surgeons to measure the eye and enhance surgical outcomes in real-time. By facilitating the convergence of refractive and cataract surgery, WaveTec Vision aims to improve the overall efficacy and precision of these procedures, ultimately benefiting patient care and satisfaction.

Benvenue Medical, Inc. is a company specializing in the design, manufacture, and marketing of minimally invasive expandable implant systems for the treatment of spinal disorders, specifically vertebral compression fractures and degenerative disc diseases. Its product offerings include the Kiva system, which addresses spinal fractures in the thoracic and lumbar regions, and the Blazer – C system, designed for treating pathological vertebral compression fractures. Additionally, Benvenue Medical has introduced the Luna 3D, an expandable interbody fusion system suitable for various surgical approaches. The company serves a diverse customer base across the United States, Canada, Belgium, France, and Germany. Founded in 2004, Benvenue Medical is headquartered in Santa Clara, California, and is focused on developing innovative surgical solutions that enhance patient outcomes and restore spinal alignment.

Astute Medical, Inc. is a life science tools company focused on improving the diagnosis of high-risk medical conditions through the discovery and development of protein biomarkers. Founded in 2007 and based in San Diego, California, with an additional location in Paris, France, the company specializes in creating novel diagnostic tests that enable rapid diagnosis and risk assessment for conditions such as abdominal pain, acute coronary syndromes, cerebrovascular injury, kidney injury, and sepsis. Astute Medical's flagship product, NephroCheck, is a single-use cartridge designed to detect biomarkers associated with acute kidney injury, while the Astute140 meter converts the test's fluorescent signal into a single numerical result. The company markets its products primarily in the United States and Europe and operates as a subsidiary of bioMérieux S.A.

TRIA Beauty, Inc. is a developer and marketer of light-based medical devices aimed at the consumer market, specializing in beauty and skincare solutions. Founded in 2003 and headquartered in Dublin, California, the company offers a range of innovative products including a hand-held, cordless diode laser for hair removal, a Skin Perfecting Blue Light device for acne treatment, a Skin Rejuvenating Laser for anti-aging purposes, and an Age-Defying Eye Wrinkle Correcting Laser. These devices utilize advanced light technology, which is preferred by dermatologists for effective skincare treatments, allowing users to achieve professional results at home. TRIA Beauty products are available through its e-commerce platform and various indirect sales channels, including retail outlets, television, and physician offices. The company serves a global market, reaching customers in the United States, Japan, South Korea, Canada, the United Kingdom, Germany, and Spain.

EBR Systems, Inc., established in 2003 and based in Sunnyvale, California, specializes in developing implantable systems for wireless tissue stimulation. The company focuses on treating cardiac arrhythmias by creating devices that improve heart function through wireless cardiac stimulation. Its flagship product is the Wise CRT System, which employs proprietary wireless technology to deliver pacing stimulation directly inside the left ventricle of the heart, enhancing its pumping efficiency and synchronizing rhythms.

Spiracur Inc. is a privately held medical device company established in 2007 through the Stanford Biodesign Innovation Program. The company specializes in creating advanced wound healing technologies, with a focus on enhancing patient care. Its flagship product, the SNaP Wound Care System, was developed to address the limitations of traditional negative pressure wound therapies, which can be cumbersome for both patients and healthcare providers. The SNaP system offers a portable, non-powdered solution for chronic wound therapy, particularly benefiting diabetic patients with challenging wounds that require efficient healing. Spiracur's commitment to patient-centric design aims to improve the overall experience and outcomes in wound care management.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

Astute Medical, Inc. is a life science tools company focused on improving the diagnosis of high-risk medical conditions through the discovery and development of protein biomarkers. Founded in 2007 and based in San Diego, California, with an additional location in Paris, France, the company specializes in creating novel diagnostic tests that enable rapid diagnosis and risk assessment for conditions such as abdominal pain, acute coronary syndromes, cerebrovascular injury, kidney injury, and sepsis. Astute Medical's flagship product, NephroCheck, is a single-use cartridge designed to detect biomarkers associated with acute kidney injury, while the Astute140 meter converts the test's fluorescent signal into a single numerical result. The company markets its products primarily in the United States and Europe and operates as a subsidiary of bioMérieux S.A.

TearScience, Inc. is a medical device company based in Morrisville, North Carolina, specializing in the identification, diagnosis, and treatment of meibomian gland disease (MGD), a primary cause of dry eye affecting millions worldwide. Founded in 2005, TearScience has developed innovative devices to address evaporative dry eye, including the LipiFlow Activator, which delivers automated therapeutic energies to treat the meibomian glands, and the LipiScan, an imaging tool that allows eye care professionals to assess gland health. The company's integrated system enables effective management of MGD, which is often underestimated despite being a leading contributor to dry eye symptoms such as irritation, dryness, and visual disturbances. As a subsidiary of Johnson & Johnson Surgical Vision, TearScience continues to advance its mission of improving patient outcomes through early detection and treatment of this chronic condition.

Viracta Therapeutics, Inc. is a clinical-stage drug development company based in Cardiff, California, that specializes in precision oncology focused on virus-associated malignancies. The company utilizes a viral activation therapy platform to develop treatments for cancers linked to the Epstein-Barr Virus (EBV) and other virus-related diseases. Its lead investigational drug, nanatinostat, is being evaluated in combination with the antiviral valganciclovir as a potential oral therapy for EBV-positive lymphoma, including post-transplant lymphoproliferative disorder, plasmablastic lymphoma, and angioimmunoblastic T cell lymphoma. Viracta is also exploring the application of this approach to other EBV-associated conditions, such as nasopharyngeal carcinoma and gastric carcinoma. Founded in 2007 and rebranded from HemaQuest Pharmaceuticals in 2015, Viracta Therapeutics is actively conducting multiple clinical trials to advance its therapeutic candidates.

Articulinx, Inc. is a medical device company based in Cupertino, California, established in 2007. The company specializes in the development and manufacturing of minimally-invasive implants and devices aimed at treating hand osteoarthritis. Articulinx's products are designed to restore joint mobility and alleviate joint pain, thereby reducing the need for more invasive surgical interventions. The company primarily serves the orthopedic, extremities, and small joints markets in the United States. Through its innovative offerings, Articulinx seeks to enhance patient outcomes and improve the quality of life for individuals suffering from joint pain.

Pulmonx Corporation is a medical technology company specializing in minimally invasive solutions for the diagnosis and treatment of chronic obstructive pulmonary disease (COPD), particularly severe emphysema. Its primary offerings include the Zephyr Endobronchial Valve, designed for patients with hyperinflation due to emphysema, as well as the Chartis Pulmonary Assessment System, which assesses collateral ventilation, and the StratX Lung Analysis Platform, a cloud-based service that analyzes computed tomography data to identify suitable treatment areas. Pulmonx aims to improve the quality of life for patients who remain symptomatic despite medical management and may not be candidates for surgical interventions. The company has received FDA pre-market approval for the Zephyr Valve and has established a global presence, serving markets in the United States, Europe, the Middle East, Africa, and the Asia-Pacific region. Founded in 1995 and headquartered in Redwood City, California, Pulmonx has become a leader in interventional procedures for COPD, supported by extensive clinical evidence demonstrating the effectiveness of its technologies.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

EBR Systems, Inc., established in 2003 and based in Sunnyvale, California, specializes in developing implantable systems for wireless tissue stimulation. The company focuses on treating cardiac arrhythmias by creating devices that improve heart function through wireless cardiac stimulation. Its flagship product is the Wise CRT System, which employs proprietary wireless technology to deliver pacing stimulation directly inside the left ventricle of the heart, enhancing its pumping efficiency and synchronizing rhythms.

Spinal Modulation, Inc., headquartered in Menlo Park, California, specializes in the development of advanced medical devices aimed at treating chronic pain. The company's flagship product, the Axium Neurostimulator System, represents a novel approach to pain management through intraspinal neuromodulation. This system specifically stimulates the dorsal root ganglion (DRG), providing an innovative alternative for patients suffering from chronic intractable leg pain and other challenging pain conditions such as those affecting the back and foot. By effectively targeting the DRG, the Axium system offers the ability to deliver adjustable therapies that can be tailored to address both broad and localized pain areas, while minimizing discomfort associated with traditional spinal cord stimulators. This technology addresses a significant unmet need in pain management, aiming to alleviate the burden on patients and healthcare systems alike.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

Spinal Kinetics LLC is a medical device company based in Sunnyvale, California, founded in 2003. The company specializes in the design and development of non-fusion motion preservation systems for treating degenerative diseases of the cervical and lumbar spine. Its flagship products, the M6-C and M6-L artificial discs, offer innovative options for artificial cervical and lumbar disc replacements, respectively. These discs are uniquely engineered to replicate the anatomical and biomechanical properties of natural intervertebral discs by incorporating an artificial nucleus and annulus. Spinal Kinetics collaborates with spine surgeons to enhance the effectiveness of its devices, which are distributed in various countries, including Australia, Germany, Spain, and the United Kingdom. The company operates as a subsidiary of Orthofix Medical Inc.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

Spiracur Inc. is a privately held medical device company established in 2007 through the Stanford Biodesign Innovation Program. The company specializes in creating advanced wound healing technologies, with a focus on enhancing patient care. Its flagship product, the SNaP Wound Care System, was developed to address the limitations of traditional negative pressure wound therapies, which can be cumbersome for both patients and healthcare providers. The SNaP system offers a portable, non-powdered solution for chronic wound therapy, particularly benefiting diabetic patients with challenging wounds that require efficient healing. Spiracur's commitment to patient-centric design aims to improve the overall experience and outcomes in wound care management.

Facet Solutions, established in 2003 and headquartered in Hopkinton, Massachusetts, specializes in developing surgical devices for treating degenerative spinal disorders. The company's primary product is an anatomic facet joint reconstruction device, designed to provide patients with lumbar spinal stenosis and facet degeneration a motion preservation alternative to lumbar spinal fusion.

PhotoThera is currently hiring for the following positions: Sr. Software Engineer Mechanical Engineer Configuration Management Engineer Sr. Electrical Engineer Send your resume and cover letter to ktitano@photothera.com, or go to www.photothera.com for further information. Specialties laser, medical device, eschemic, stroke, infrared

iScience Interventional specializes in developing innovative medical technologies for ophthalmic interventions. They focus on creating advanced microcatheters and imaging systems, enabling eye specialists to precisely administer therapies to specific locations within the eye. Additionally, they offer medical devices for canaloplasty procedures.

SynergEyes, Inc. is a technology-driven company specializing in the development and manufacturing of hybrid contact lenses designed to enhance vision and improve quality of life for patients. Founded in 2001 and headquartered in Carlsbad, California, SynergEyes offers innovative products that combine the visual acuity of rigid gas permeable lenses with the comfort of soft lenses. Their hybrid lenses cater to a range of eye conditions, including astigmatism, presbyopia, myopia, hyperopia, and keratoconus, utilizing advanced high-Dk materials and vision-optimized designs. The company distributes its products both domestically and internationally, emphasizing a commitment to improving eye health and transforming vision for eye care professionals and their patients.

WaveTec Vision, founded in 1997 and located in Aliso Viejo, California, specializes in advanced wavefront measurement technology for cataract surgery. The company's proprietary intraoperative aberrometer system, ORange, allows surgeons to measure the eye and enhance surgical outcomes in real-time. By facilitating the convergence of refractive and cataract surgery, WaveTec Vision aims to improve the overall efficacy and precision of these procedures, ultimately benefiting patient care and satisfaction.

OncoMed Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Redwood City, California, focused on discovering and developing innovative therapeutics targeting the biological mechanisms underlying cancer growth, resistance, recurrence, and metastasis. The company is advancing several therapeutic candidates, including Navicixizumab, a bispecific monoclonal antibody designed to target Delta-like ligand 4 and vascular endothelial growth factor, which has undergone clinical trials for advanced solid tumors, metastatic colorectal cancer, and platinum-resistant ovarian cancer. Additionally, OncoMed is developing Etigilimab, an anti-TIGIT monoclonal antibody that is currently in clinical trials for advanced or metastatic solid tumors. The company aims to provide new treatment alternatives by leveraging its understanding of cancer stem cells, which are critical to tumor initiation. OncoMed has established strategic alliances with leading pharmaceutical companies, including Celgene Corporation and Bayer Pharma AG, to facilitate the discovery and development of novel therapeutics. Founded in 2004, OncoMed Pharmaceuticals operates as a subsidiary of Mereo BioPharma Group plc.

InSound Medical, Inc. is a privately held company located in Newark, California, that specializes in the development and manufacturing of advanced hearing solutions. The company is known for its innovative product, Lyric, which is an invisible extended wear hearing device designed to provide discreet and convenient hearing assistance. InSound Medical is supported by notable investors, including Johnson & Johnson and various venture capital firms, reflecting its commitment to advancing hearing technology and improving the quality of life for individuals with hearing impairments.

Sierra Surgical Technologies develops minimally invasive surgical systems. The company develops female sterilization technology. Sierra Surgical Technologies, Inc. is based in Palo Alto, California.

MyoScience Inc., founded in 2005 and based in Redwood City, California, focuses on the development and commercialization of innovative dermatological products. The company leverages advanced technology to create solutions aimed at addressing various skin-related issues. Through its efforts, MyoScience aims to provide effective products that enhance skin health and appearance.

EBR Systems, Inc., established in 2003 and based in Sunnyvale, California, specializes in developing implantable systems for wireless tissue stimulation. The company focuses on treating cardiac arrhythmias by creating devices that improve heart function through wireless cardiac stimulation. Its flagship product is the Wise CRT System, which employs proprietary wireless technology to deliver pacing stimulation directly inside the left ventricle of the heart, enhancing its pumping efficiency and synchronizing rhythms.

Astute Medical, Inc. is a life science tools company focused on improving the diagnosis of high-risk medical conditions through the discovery and development of protein biomarkers. Founded in 2007 and based in San Diego, California, with an additional location in Paris, France, the company specializes in creating novel diagnostic tests that enable rapid diagnosis and risk assessment for conditions such as abdominal pain, acute coronary syndromes, cerebrovascular injury, kidney injury, and sepsis. Astute Medical's flagship product, NephroCheck, is a single-use cartridge designed to detect biomarkers associated with acute kidney injury, while the Astute140 meter converts the test's fluorescent signal into a single numerical result. The company markets its products primarily in the United States and Europe and operates as a subsidiary of bioMérieux S.A.

CardioMind, Inc. Inc manufactures therapeutic devices for cardiovascular diseases. The company also offers stent delivery systems, which are designed for use in lesion applications, as well as for the treatment of coronary and peripheral artery diseases. In addition, it provides invasive endovascular medical devices for treating neurological and cardiovascular diseases. The company was founded in 2003 and is based in Sunnyvale, California.

InSound Medical, Inc. is a privately held company located in Newark, California, that specializes in the development and manufacturing of advanced hearing solutions. The company is known for its innovative product, Lyric, which is an invisible extended wear hearing device designed to provide discreet and convenient hearing assistance. InSound Medical is supported by notable investors, including Johnson & Johnson and various venture capital firms, reflecting its commitment to advancing hearing technology and improving the quality of life for individuals with hearing impairments.

Avedro, Inc. is a commercial-stage ophthalmic pharmaceutical and medical device company headquartered in Waltham, Massachusetts. The company specializes in developing and commercializing innovative products for treating corneal disorders, primarily focusing on corneal ectatic conditions and refractive issues. Avedro's proprietary Corneal Remodeling Platform includes the KXL and Mosaic systems, which utilize ultraviolet A (UVA) light in conjunction with riboflavin drug formulations for corneal cross-linking. This technology is aimed at strengthening and reshaping the cornea through minimally invasive and non-invasive outpatient procedures. Avedro has also introduced the Keraflex refractive correction procedure, a non-invasive technique for flattening the cornea without tissue removal. While Avedro primarily serves ophthalmologists, hospitals, and ambulatory surgery centers in the United States, it also markets its products internationally through medical device distributors. The company, originally named ThermalVision, Inc., was incorporated in 2002 and rebranded as Avedro in 2005. As of November 2019, Avedro operates as a subsidiary of Glaukos Corporation.

Benvenue Medical, Inc. is a company specializing in the design, manufacture, and marketing of minimally invasive expandable implant systems for the treatment of spinal disorders, specifically vertebral compression fractures and degenerative disc diseases. Its product offerings include the Kiva system, which addresses spinal fractures in the thoracic and lumbar regions, and the Blazer – C system, designed for treating pathological vertebral compression fractures. Additionally, Benvenue Medical has introduced the Luna 3D, an expandable interbody fusion system suitable for various surgical approaches. The company serves a diverse customer base across the United States, Canada, Belgium, France, and Germany. Founded in 2004, Benvenue Medical is headquartered in Santa Clara, California, and is focused on developing innovative surgical solutions that enhance patient outcomes and restore spinal alignment.

POINT Biomedical is a privately held pharmaceutical company, founded to pursue technologies related to imaging and drug delivery. POINT's core technology is based upon an ultrasonically responsive two-layer, biodegradable microsphere or biSphereâ„¢. One of the most important features of this technology is the ability to noninvasively trigger the biSpheres to release their contents at sites within the body using externally generated pulses of ultrasound. From this basic platform, POINT is developing a pipeline of products that leverage the unique properties of the biSphere technology in the areas of imaging and therapeutics. POINT has initially focused development of this platform on the assessment of tissue specific blood flow. The lead product, CARDIOsphereâ„¢, is a pharmaceutical agent that will enable cardiologists to perform myocardial perfusion imaging studies in the office setting using ultrasound rather than more expensive and cumbersome nuclear (or radioisotope) techniques

AxoGen, Inc. is a company focused on developing and commercializing innovative solutions for the repair and regeneration of peripheral nerve injuries. Based in Alachua, Florida, and founded in 2002, AxoGen offers a range of products designed for effective surgical procedures, including the AVANCE Nerve Graft, Axoguard Nerve Connector, Axoguard Nerve Protector, Axoguard Nerve Cap, and Avive Soft Tissue Membrane. Additionally, it provides the Axotouch Two-Point Discriminator, a device used to assess the innervation density of skin. AxoGen's offerings are aimed at surgeons and healthcare providers, ensuring clinically and economically effective solutions for nerve repair. The company also has a strategic partnership with the American Tissue Services Foundation for tissue recovery and distributes its products across the United States and several international markets, including Canada, Germany, the United Kingdom, Spain, and South Korea.

Viracta Therapeutics, Inc. is a clinical-stage drug development company based in Cardiff, California, that specializes in precision oncology focused on virus-associated malignancies. The company utilizes a viral activation therapy platform to develop treatments for cancers linked to the Epstein-Barr Virus (EBV) and other virus-related diseases. Its lead investigational drug, nanatinostat, is being evaluated in combination with the antiviral valganciclovir as a potential oral therapy for EBV-positive lymphoma, including post-transplant lymphoproliferative disorder, plasmablastic lymphoma, and angioimmunoblastic T cell lymphoma. Viracta is also exploring the application of this approach to other EBV-associated conditions, such as nasopharyngeal carcinoma and gastric carcinoma. Founded in 2007 and rebranded from HemaQuest Pharmaceuticals in 2015, Viracta Therapeutics is actively conducting multiple clinical trials to advance its therapeutic candidates.

Vitreoretinal Technologies, Inc., an ophthalmic biopharmaceutical company, engages in the development and commercialization of therapeutic compounds for the treatment of ophthalmic diseases. The company focuses on vitreoretinal ophthalmic diseases and complications related to ophthalmic surgery. Its products include Vitreosolve, a drug used for the treatment of diabetic retinopathy, as well as to liquefy the vitreous gel prior to vitrectomy surgery; and Neurosolve, a compound used for glaucomatous optic nerve damage progression prevention, dry age related macular degeneration progression, and retinitis pigmentosa treatment.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

Sierra Surgical Technologies develops minimally invasive surgical systems. The company develops female sterilization technology. Sierra Surgical Technologies, Inc. is based in Palo Alto, California.

CardioMind, Inc. Inc manufactures therapeutic devices for cardiovascular diseases. The company also offers stent delivery systems, which are designed for use in lesion applications, as well as for the treatment of coronary and peripheral artery diseases. In addition, it provides invasive endovascular medical devices for treating neurological and cardiovascular diseases. The company was founded in 2003 and is based in Sunnyvale, California.

Paracor Medical is a medical device company established in 1999 that specializes in developing innovative, technology-driven solutions for the treatment of heart failure. The company focuses on creating alternatives to traditional open chest surgery, aiming to alleviate the burden on patients with failing heart muscles. By employing a mechanical approach, Paracor Medical seeks to enhance the effectiveness of heart failure treatment while minimizing the invasiveness of procedures.

WaveTec Vision, founded in 1997 and located in Aliso Viejo, California, specializes in advanced wavefront measurement technology for cataract surgery. The company's proprietary intraoperative aberrometer system, ORange, allows surgeons to measure the eye and enhance surgical outcomes in real-time. By facilitating the convergence of refractive and cataract surgery, WaveTec Vision aims to improve the overall efficacy and precision of these procedures, ultimately benefiting patient care and satisfaction.

Talima Therapeutics is an emerging drug delivery company dedicated to the development of novel products that increase patient choice and improve quality of life. With a unique approach to therapy, we design customized drug-delivery systems that optimize the local therapeutic performance and reduce the undesired systemic side effects enabling us to address unmet needs or underserved markets. We foster a collaborative environment and strive for excellence internally and with our partners. Our lead product is currently in Phase I/II clinical testing for the treatment of onychomycosis, a fungal disease of the nails and we are in the process of planning its pivotal trials.

TRIA Beauty, Inc. is a developer and marketer of light-based medical devices aimed at the consumer market, specializing in beauty and skincare solutions. Founded in 2003 and headquartered in Dublin, California, the company offers a range of innovative products including a hand-held, cordless diode laser for hair removal, a Skin Perfecting Blue Light device for acne treatment, a Skin Rejuvenating Laser for anti-aging purposes, and an Age-Defying Eye Wrinkle Correcting Laser. These devices utilize advanced light technology, which is preferred by dermatologists for effective skincare treatments, allowing users to achieve professional results at home. TRIA Beauty products are available through its e-commerce platform and various indirect sales channels, including retail outlets, television, and physician offices. The company serves a global market, reaching customers in the United States, Japan, South Korea, Canada, the United Kingdom, Germany, and Spain.

Pulmonx Corporation is a medical technology company specializing in minimally invasive solutions for the diagnosis and treatment of chronic obstructive pulmonary disease (COPD), particularly severe emphysema. Its primary offerings include the Zephyr Endobronchial Valve, designed for patients with hyperinflation due to emphysema, as well as the Chartis Pulmonary Assessment System, which assesses collateral ventilation, and the StratX Lung Analysis Platform, a cloud-based service that analyzes computed tomography data to identify suitable treatment areas. Pulmonx aims to improve the quality of life for patients who remain symptomatic despite medical management and may not be candidates for surgical interventions. The company has received FDA pre-market approval for the Zephyr Valve and has established a global presence, serving markets in the United States, Europe, the Middle East, Africa, and the Asia-Pacific region. Founded in 1995 and headquartered in Redwood City, California, Pulmonx has become a leader in interventional procedures for COPD, supported by extensive clinical evidence demonstrating the effectiveness of its technologies.

TearScience, Inc. is a medical device company based in Morrisville, North Carolina, specializing in the identification, diagnosis, and treatment of meibomian gland disease (MGD), a primary cause of dry eye affecting millions worldwide. Founded in 2005, TearScience has developed innovative devices to address evaporative dry eye, including the LipiFlow Activator, which delivers automated therapeutic energies to treat the meibomian glands, and the LipiScan, an imaging tool that allows eye care professionals to assess gland health. The company's integrated system enables effective management of MGD, which is often underestimated despite being a leading contributor to dry eye symptoms such as irritation, dryness, and visual disturbances. As a subsidiary of Johnson & Johnson Surgical Vision, TearScience continues to advance its mission of improving patient outcomes through early detection and treatment of this chronic condition.

Ovalis is a biotechnology company that develops catheter-based medical devices for the repair of cardiovascular defects.The company is based in Mountain View, California.

InSound Medical, Inc. is a privately held company located in Newark, California, that specializes in the development and manufacturing of advanced hearing solutions. The company is known for its innovative product, Lyric, which is an invisible extended wear hearing device designed to provide discreet and convenient hearing assistance. InSound Medical is supported by notable investors, including Johnson & Johnson and various venture capital firms, reflecting its commitment to advancing hearing technology and improving the quality of life for individuals with hearing impairments.

SynergEyes, Inc. is a technology-driven company specializing in the development and manufacturing of hybrid contact lenses designed to enhance vision and improve quality of life for patients. Founded in 2001 and headquartered in Carlsbad, California, SynergEyes offers innovative products that combine the visual acuity of rigid gas permeable lenses with the comfort of soft lenses. Their hybrid lenses cater to a range of eye conditions, including astigmatism, presbyopia, myopia, hyperopia, and keratoconus, utilizing advanced high-Dk materials and vision-optimized designs. The company distributes its products both domestically and internationally, emphasizing a commitment to improving eye health and transforming vision for eye care professionals and their patients.

PhotoThera is currently hiring for the following positions: Sr. Software Engineer Mechanical Engineer Configuration Management Engineer Sr. Electrical Engineer Send your resume and cover letter to ktitano@photothera.com, or go to www.photothera.com for further information. Specialties laser, medical device, eschemic, stroke, infrared

Cartilix develops and commercializes biomaterials to repair damaged tissues in articular joints and other applications. It focuses on a technology for cartilage filling in regenerative medicine. The company was founded in 2004 and is based in Foster City, California.

Spinal Modulation, Inc., headquartered in Menlo Park, California, specializes in the development of advanced medical devices aimed at treating chronic pain. The company's flagship product, the Axium Neurostimulator System, represents a novel approach to pain management through intraspinal neuromodulation. This system specifically stimulates the dorsal root ganglion (DRG), providing an innovative alternative for patients suffering from chronic intractable leg pain and other challenging pain conditions such as those affecting the back and foot. By effectively targeting the DRG, the Axium system offers the ability to deliver adjustable therapies that can be tailored to address both broad and localized pain areas, while minimizing discomfort associated with traditional spinal cord stimulators. This technology addresses a significant unmet need in pain management, aiming to alleviate the burden on patients and healthcare systems alike.

Spinal Kinetics LLC is a medical device company based in Sunnyvale, California, founded in 2003. The company specializes in the design and development of non-fusion motion preservation systems for treating degenerative diseases of the cervical and lumbar spine. Its flagship products, the M6-C and M6-L artificial discs, offer innovative options for artificial cervical and lumbar disc replacements, respectively. These discs are uniquely engineered to replicate the anatomical and biomechanical properties of natural intervertebral discs by incorporating an artificial nucleus and annulus. Spinal Kinetics collaborates with spine surgeons to enhance the effectiveness of its devices, which are distributed in various countries, including Australia, Germany, Spain, and the United Kingdom. The company operates as a subsidiary of Orthofix Medical Inc.

Facet Solutions, established in 2003 and headquartered in Hopkinton, Massachusetts, specializes in developing surgical devices for treating degenerative spinal disorders. The company's primary product is an anatomic facet joint reconstruction device, designed to provide patients with lumbar spinal stenosis and facet degeneration a motion preservation alternative to lumbar spinal fusion.

FlowMedica is a medical device company specializing in intravascular systems for Targeted Renal Therapy. The company develops innovative solutions aimed at addressing kidney dysfunction associated with cardiovascular disease, cancer, and surgical procedures. Its flagship product, the Benephit CV Infusion System, enables physicians to deliver therapeutic agents directly into the renal arteries through an infusion catheter, facilitating simultaneous coronary procedures via a single access point in the femoral artery. Additionally, the Benephit XTMini Infusion System caters to patients with smaller vascular anatomies by allowing bilateral infusion to the kidneys. FlowMedica's devices present a precise alternative to traditional systemic intravenous infusion methods, enabling surgeons to administer treatments directly and accurately.

Ovalis is a biotechnology company that develops catheter-based medical devices for the repair of cardiovascular defects.The company is based in Mountain View, California.

PhotoThera is currently hiring for the following positions: Sr. Software Engineer Mechanical Engineer Configuration Management Engineer Sr. Electrical Engineer Send your resume and cover letter to ktitano@photothera.com, or go to www.photothera.com for further information. Specialties laser, medical device, eschemic, stroke, infrared

EBR Systems, Inc., established in 2003 and based in Sunnyvale, California, specializes in developing implantable systems for wireless tissue stimulation. The company focuses on treating cardiac arrhythmias by creating devices that improve heart function through wireless cardiac stimulation. Its flagship product is the Wise CRT System, which employs proprietary wireless technology to deliver pacing stimulation directly inside the left ventricle of the heart, enhancing its pumping efficiency and synchronizing rhythms.

Talima Therapeutics is an emerging drug delivery company dedicated to the development of novel products that increase patient choice and improve quality of life. With a unique approach to therapy, we design customized drug-delivery systems that optimize the local therapeutic performance and reduce the undesired systemic side effects enabling us to address unmet needs or underserved markets. We foster a collaborative environment and strive for excellence internally and with our partners. Our lead product is currently in Phase I/II clinical testing for the treatment of onychomycosis, a fungal disease of the nails and we are in the process of planning its pivotal trials.

iScience Surgical, Inc. is a privately-held company founded in 1999. It is developing high resolution imaging systems and microsurgical instruments for the treatment of glaucoma. The Company's products are designed to complement existing glaucoma surgical techniques and serve as a platform for a new generation of minimally invasive procedures. Glaucoma is a sight threatening circulatory disorder of the eye that affects approximately 4.2 million Americans and 69 million people worldwide. More than $2 billion is spent annually on glaucoma medications and treatments worldwide, the majority of which are unable to restore the eye's natural drainage process.

Paracor Medical is a medical device company established in 1999 that specializes in developing innovative, technology-driven solutions for the treatment of heart failure. The company focuses on creating alternatives to traditional open chest surgery, aiming to alleviate the burden on patients with failing heart muscles. By employing a mechanical approach, Paracor Medical seeks to enhance the effectiveness of heart failure treatment while minimizing the invasiveness of procedures.

EBR Systems, Inc., established in 2003 and based in Sunnyvale, California, specializes in developing implantable systems for wireless tissue stimulation. The company focuses on treating cardiac arrhythmias by creating devices that improve heart function through wireless cardiac stimulation. Its flagship product is the Wise CRT System, which employs proprietary wireless technology to deliver pacing stimulation directly inside the left ventricle of the heart, enhancing its pumping efficiency and synchronizing rhythms.

Spinal Kinetics LLC is a medical device company based in Sunnyvale, California, founded in 2003. The company specializes in the design and development of non-fusion motion preservation systems for treating degenerative diseases of the cervical and lumbar spine. Its flagship products, the M6-C and M6-L artificial discs, offer innovative options for artificial cervical and lumbar disc replacements, respectively. These discs are uniquely engineered to replicate the anatomical and biomechanical properties of natural intervertebral discs by incorporating an artificial nucleus and annulus. Spinal Kinetics collaborates with spine surgeons to enhance the effectiveness of its devices, which are distributed in various countries, including Australia, Germany, Spain, and the United Kingdom. The company operates as a subsidiary of Orthofix Medical Inc.

InSound Medical, Inc. is a privately held company located in Newark, California, that specializes in the development and manufacturing of advanced hearing solutions. The company is known for its innovative product, Lyric, which is an invisible extended wear hearing device designed to provide discreet and convenient hearing assistance. InSound Medical is supported by notable investors, including Johnson & Johnson and various venture capital firms, reflecting its commitment to advancing hearing technology and improving the quality of life for individuals with hearing impairments.

Bacchus Vascular, Inc. is a medical device company based in Santa Clara, California, specializing in the treatment of occlusive vascular disease. Founded in 1999, the company develops innovative therapeutic solutions for interventional radiologists and vascular surgeons in the United States. One of its key products is the TRELLIS-8 Peripheral Infusion System, which features an isolated thrombolysis catheter designed for the targeted delivery of clot-dissolving drugs to treat conditions such as deep vein thrombosis and arterial occlusions. Additionally, Bacchus Vascular is involved in procedures for the percutaneous removal of blood clots from both dialysis and peripheral grafts, as well as native arteries and veins, further addressing the needs of patients with vascular complications.

iScience Interventional specializes in developing innovative medical technologies for ophthalmic interventions. They focus on creating advanced microcatheters and imaging systems, enabling eye specialists to precisely administer therapies to specific locations within the eye. Additionally, they offer medical devices for canaloplasty procedures.

iScience Surgical, Inc. is a privately-held company founded in 1999. It is developing high resolution imaging systems and microsurgical instruments for the treatment of glaucoma. The Company's products are designed to complement existing glaucoma surgical techniques and serve as a platform for a new generation of minimally invasive procedures. Glaucoma is a sight threatening circulatory disorder of the eye that affects approximately 4.2 million Americans and 69 million people worldwide. More than $2 billion is spent annually on glaucoma medications and treatments worldwide, the majority of which are unable to restore the eye's natural drainage process.

LuMend Inc. designs, develops, manufactures and markets medical devices intended to enable physicians to safely, predictably and cost effectively cross Chronic Total Occlusions (CTO) in the coronary vasculature, allowing subsequent conventional guide wire placement across target stenotic lesions. The company was founded in 1996 by two pioneering interventional cardiologists, John Simpson, PhD, MD, and Matthew Selmon, MD.

Renovis, Inc. is a biopharmaceutical company focused on developing innovative drugs for neurological diseases and disorders. The company is actively engaged in creating treatments for acute ischemic stroke, neuropathic pain, and acute post-operative pain. Utilizing advanced techniques in molecular biology, medicinal chemistry, and pharmacology, Renovis identifies and selects small molecule drug candidates that adhere to rigorous development standards. Through a combination of in vitro and in vivo studies, drug metabolism and pharmacokinetics assessments, and toxicological evaluations, Renovis aims to deliver effective therapeutic solutions to address significant unmet medical needs in neurology.

MicroVention Terumo is a medical device company headquartered in Tustin, California, specializing in catheter-based and minimally invasive neuroendovascular technologies aimed at treating cerebral aneurysms and other neurovascular diseases. Founded in 1997, it operates as a subsidiary of Terumo Corporation. The company develops a range of products, including delivery and detachment systems, access products, intraluminal devices, occlusion balloons, and flow diverters. Notably, MicroVention Terumo offers advanced embolization solutions such as the HydroCoil Embolic System, which utilizes platinum micro-coil technology, and the MicroPlex Coil System, which features a combination of framing, helical filling, and finishing coils to effectively address various types of aneurysm morphologies. Its products are distributed through a network of specialty distributors across North America, South America, Europe, Africa, the Middle East, and Asia Pacific, contributing to improved patient outcomes in the treatment of vascular conditions.