Telegraph Hill Partners

Telegraph Hill Partners, established in 2001, is a San Francisco-based venture capital firm specializing in investments within the life science, medical devices, and healthcare sectors. The firm, founded by J. Matthew Mackowski, Robert Shepler, Dr. Thomas Raffin, and Deval Lashkari, focuses on backing technology leaders in the United States. Telegraph Hill Partners prefers to invest in companies with revenues ranging between USD 5 million and USD 50 million, targeting sectors such as pharmaceuticals, biotechnology, diagnostics, healthcare information technology, and other related healthcare fields.

Rob Capone

Partner

Gary Curtis

Venture Partner

Alex Efron

Senior Associate

Paul Grossman

Partner

Deval A. Lashkari

Co-Founder and Senior Partner

J. Matthew Mackowski

Chairman, Managing Director

Glenn Novotny

Operating Partner

Thomas A. Raffin

Co-Founder, Senior Partner and Venture Partner

44 past transactions

Argonaut Manufacturing Services

Series A in 2024
Argonaut Manufacturing Services specializes in contract manufacturing for the biopharmaceutical, diagnostics, and life sciences sectors. The company offers a comprehensive suite of services, including high-yield aseptic fill/finish, reagent formulation, filling, kitting, lyophilization, and analytical support. By providing these essential services, Argonaut enables its clients to meet diverse outsourcing needs and efficiently produce a wide range of diagnostics and drug products.

Cell Microsystems

Series B in 2023
Cell Microsystems, Inc. is a biotechnology company based in Research Triangle Park, North Carolina, that focuses on developing, manufacturing, and commercializing innovative tools for single-cell biology. Founded in 2010, the company is known for its proprietary CellRaft™ Technology, which allows for the efficient sorting and isolation of single cells under standard culture conditions, preserving their unperturbed phenotypes and high viability. This technology is complemented by an automated imaging platform, enabling real-time selection and tracking of individual cells throughout imaging, collection, and downstream analysis. By facilitating single-cell isolation from small and valuable samples, Cell Microsystems provides scalable solutions that make advanced cell separation technology accessible to laboratories, enhancing the capabilities of researchers in single-cell research and genomics.

Panome Bio

Venture Round in 2023
Panome Bio is a biomarker discovery platform founded in 2022 and headquartered in Saint Louis, Missouri. The company specializes in metabolomics technologies that facilitate biomarker discovery and metabolite profiling. Panome Bio offers a range of services, including global metabolomics analysis, lipidomics, and proteomics screening solutions, utilizing untargeted analysis and proprietary computational methods. Its comprehensive workflows and personalized data analysis reports provide clients with a global and unbiased view of the metabolome, capturing the diversity of metabolites present in biological systems.

Emerging Therapy Solutions

Venture Round in 2022
Emerging Therapy Solutions, Inc. is a company based in Bloomington, Minnesota, that specializes in the outsourced management of cell and gene therapy treatments for healthcare payers. Founded in 2018, it offers a comprehensive range of services including patient management, data collection, analysis, reporting, and claims administration. The company focuses on developing proprietary algorithms that enable effective targeting and segmentation of rare conditions. By providing a predictive intelligence platform, Emerging Therapy Solutions aims to simplify the management of complex therapy treatments, thereby enhancing the efficiency of healthcare providers in managing these advanced therapies.

Mosaic Biosciences

Venture Round in 2022
Mosaic Biosciences, Inc. is a Colorado-based company focused on developing innovative biomaterials for tissue engineering applications. Founded in 2009, the firm specializes in creating synthetic extracellular materials that facilitate research and development in protein and antibody therapeutics. Its technology platform supports the incorporation of biological factors, such as proteins, peptides, and nucleic acids, enabling biopharma partners to advance therapeutic programs from initial concepts to viable drug candidates. Mosaic Biosciences also collaborates strategically with other entities to enhance its capabilities in drug discovery and development, making substantial contributions to areas like drug delivery, regenerative medicine, and stem cell therapies.

Excellos

Funding Round in 2022
Excellos is a company specializing in the development and manufacture of cell and gene therapies, with a focus on advancing these innovative treatments. They provide development and clinical manufacturing services for various therapies, including CAR-T, tumor-infiltrating lymphocyte therapy, and immunotherapy. Excellos offers cGMP cellular products and services to scientists and physicians working in this field, along with expertise in process development and manufacturing. The company's mission is to accelerate the development of cellular therapies, enabling these powerful medications to reach their full potential and save lives.

Cell Microsystems

Venture Round in 2021
Cell Microsystems, Inc. is a biotechnology company based in Research Triangle Park, North Carolina, that focuses on developing, manufacturing, and commercializing innovative tools for single-cell biology. Founded in 2010, the company is known for its proprietary CellRaft™ Technology, which allows for the efficient sorting and isolation of single cells under standard culture conditions, preserving their unperturbed phenotypes and high viability. This technology is complemented by an automated imaging platform, enabling real-time selection and tracking of individual cells throughout imaging, collection, and downstream analysis. By facilitating single-cell isolation from small and valuable samples, Cell Microsystems provides scalable solutions that make advanced cell separation technology accessible to laboratories, enhancing the capabilities of researchers in single-cell research and genomics.

Carterra

Venture Round in 2020
Carterra, Inc. is a biotechnology company specializing in label-free biomolecular interaction analysis solutions. Founded in 2005 and headquartered in Salt Lake City, Utah, Carterra offers a range of products and services that facilitate multiplexing on planar array surfaces. Its flagship technologies include the MultipleX 96, an array-based surface plasmon resonance (SPR) imaging system, and the Continuous Flow Microspotter (CFM), a microarray printer that employs flow for efficient sample deposition. The company's offerings extend to contract research services, which cover high-throughput epitope binning and mapping, first-pass kinetics, and assay development. Additionally, Carterra provides a variety of supporting solutions, such as maintenance solutions, kits, and running buffers. These products are utilized in various applications, including kinetics software, epitope software, and antibody format development. Carterra also operates additional offices in Dublin, California; Andover, Massachusetts; and Munich, Germany, and sells its products through distributors in China and Japan, as well as online.

Nivagen Pharmaceuticals

Venture Round in 2020
Nivagen Pharmaceuticals, Inc. is a pharmaceutical company focused on the development, acquisition, and sales of generic prescription drugs and over-the-counter products within the North American market. Established in 2009 and headquartered in Sacramento, California, the company aims to deliver high-quality, affordable products by partnering with FDA-approved manufacturing facilities globally. Nivagen markets its offerings through various channels, including chain drug stores, regional wholesalers, mass merchandisers, hospitals, and mail order pharmacies. With a keen interest in the growing generic prescription market, which is projected to expand significantly as numerous products lose patent protection in the coming years, Nivagen is positioned to provide cost-effective solutions while adding value to the entire supply chain.

Carterra

Venture Round in 2020
Carterra, Inc. is a biotechnology company specializing in label-free biomolecular interaction analysis solutions. Founded in 2005 and headquartered in Salt Lake City, Utah, Carterra offers a range of products and services that facilitate multiplexing on planar array surfaces. Its flagship technologies include the MultipleX 96, an array-based surface plasmon resonance (SPR) imaging system, and the Continuous Flow Microspotter (CFM), a microarray printer that employs flow for efficient sample deposition. The company's offerings extend to contract research services, which cover high-throughput epitope binning and mapping, first-pass kinetics, and assay development. Additionally, Carterra provides a variety of supporting solutions, such as maintenance solutions, kits, and running buffers. These products are utilized in various applications, including kinetics software, epitope software, and antibody format development. Carterra also operates additional offices in Dublin, California; Andover, Massachusetts; and Munich, Germany, and sells its products through distributors in China and Japan, as well as online.

Akoya Biosciences

Series D in 2019
Akoya Biosciences is a spatial biology company offering the most comprehensive, end-to-end solutions for high-parameter tissue analysis from discovery through clinical and translational research, enabling the development of more precise therapies for immuno-oncology and other drug development applications. The company has two industry-leading platforms that empower investigators and researchers to gain a deeper understanding of complex diseases such as cancer, and autoimmune or neurological disorders. The CODEX system is the only benchtop platform that can efficiently quantify more than 40 biomarkers and is ideally suited for biomarker discovery. The Phenoptics platform is the only end-to-end multiplexed immunofluorescence solution with the robustness and high throughput necessary for translational research and clinical trials.

Specific Diagnostics

Venture Round in 2019
Specific Diagnostics LLC, established in 2011 and based in West Palm Beach, Florida, specializes in developing innovative solutions for bacterial detection, identification, and antibiotic susceptibility testing. The company's flagship product is the Specific Reveal system, which employs patented small molecule sensor technology to deliver rapid and cost-effective antibiotic susceptibility results, enabling clinics to tailor treatments more efficiently.

Emerging Therapy Solutions

Venture Round in 2019
Emerging Therapy Solutions, Inc. is a company based in Bloomington, Minnesota, that specializes in the outsourced management of cell and gene therapy treatments for healthcare payers. Founded in 2018, it offers a comprehensive range of services including patient management, data collection, analysis, reporting, and claims administration. The company focuses on developing proprietary algorithms that enable effective targeting and segmentation of rare conditions. By providing a predictive intelligence platform, Emerging Therapy Solutions aims to simplify the management of complex therapy treatments, thereby enhancing the efficiency of healthcare providers in managing these advanced therapies.

Nimble Therapeutics

Series A in 2019
Nimble Therapeutics is a biotechnology company focused on advancing drug discovery through its innovative maskless chemical synthesis platform. This technology enables the systematic synthesis and discovery of novel medicines across various therapeutic areas. By leveraging massively parallel chemical synthesis, Nimble Therapeutics aids in the empirical optimization of molecules, enhancing their drug-like properties. The company's approach is designed to transform the way peptide therapeutics are developed, providing medical professionals with the tools necessary for intelligent discovery and development of next-generation therapies.

Invisalert Solutions

Venture Round in 2019
Invisalert Solutions, Inc. is a healthcare technology company that focuses on developing compliance-based patient safety solutions. Founded in 2011 and headquartered in Newtown Square, Pennsylvania, the company is known for its flagship product, ObservSMART. This innovative wristband features a software-based tracker that monitors observation compliance every 15 minutes, significantly reducing the risks of missed or falsified patient information. ObservSMART enhances communication among healthcare staff, provides proactive notifications for supervisory personnel, and offers access to comprehensive reports and analytics. By replacing traditional paper-based documentation, the system aims to improve compliance and patient care, particularly in psychiatric and emergency room settings. Invisalert Solutions specializes in addressing non-compliance issues across various sectors, including acute healthcare, corrections, drug delivery, long-term care, and youth and special education markets.

Teknova

Acquisition in 2019
Teknova is a provider of essential reagents that facilitate the discovery, development, and production of biopharmaceutical products, including drug therapies, vaccines, and molecular diagnostics. The company offers a diverse range of products, such as pre-poured media plates for cell growth, liquid cell culture media and supplements, and molecular biology reagents for sample manipulation and purification. Teknova serves customers across research, clinical, and applied markets, delivering both standard catalog products and custom GMP solutions tailored to specific formulation and packaging needs. Emphasizing agility and customer satisfaction, Teknova also supports the biopharma sector with expertise in product design and guidance on GMP manufacturing processes, covering the entire workflow of cell and gene therapy production. The company's primary revenue is generated from the United States market.

Akoya Biosciences

Venture Round in 2018
Akoya Biosciences is a spatial biology company offering the most comprehensive, end-to-end solutions for high-parameter tissue analysis from discovery through clinical and translational research, enabling the development of more precise therapies for immuno-oncology and other drug development applications. The company has two industry-leading platforms that empower investigators and researchers to gain a deeper understanding of complex diseases such as cancer, and autoimmune or neurological disorders. The CODEX system is the only benchtop platform that can efficiently quantify more than 40 biomarkers and is ideally suited for biomarker discovery. The Phenoptics platform is the only end-to-end multiplexed immunofluorescence solution with the robustness and high throughput necessary for translational research and clinical trials.

Precision NanoSystem

Series B in 2018
Precision Nanosystems specializes in the development of tools and processes for the creation and manufacturing of nanoparticles used in medicine and medical research. The company offers a range of products, including the NanoAssemblr benchtop instrument, which facilitates the prototyping of nanoparticles and the development of nanoparticle-based drugs that deliver RNA, small molecules, and protein therapeutics. Additionally, Precision Nanosystems provides various kits, such as Neuro9Kit for studying gene function in neurons and glial cells, Test9Kit for gene function studies in diverse cell types, and Hepato9Kit for liver gene function analysis. Their microfluidic devices enable the rapid and cost-effective manufacturing of lipid nanoparticles that can encapsulate and deliver bioactive agents, supporting life sciences researchers in developing innovative treatments and therapies for various diseases.

Carterra

Venture Round in 2018
Carterra, Inc. is a biotechnology company specializing in label-free biomolecular interaction analysis solutions. Founded in 2005 and headquartered in Salt Lake City, Utah, Carterra offers a range of products and services that facilitate multiplexing on planar array surfaces. Its flagship technologies include the MultipleX 96, an array-based surface plasmon resonance (SPR) imaging system, and the Continuous Flow Microspotter (CFM), a microarray printer that employs flow for efficient sample deposition. The company's offerings extend to contract research services, which cover high-throughput epitope binning and mapping, first-pass kinetics, and assay development. Additionally, Carterra provides a variety of supporting solutions, such as maintenance solutions, kits, and running buffers. These products are utilized in various applications, including kinetics software, epitope software, and antibody format development. Carterra also operates additional offices in Dublin, California; Andover, Massachusetts; and Munich, Germany, and sells its products through distributors in China and Japan, as well as online.

Aquaro Histology

Series A in 2017
Aquaro Histology, Inc. specializes in the manufacturing of a section mounting system designed to enhance the histology workflow in laboratories. Founded in 2017 and headquartered in Ann Arbor, Michigan, the company offers the Aquaro ASM, an automated solution that streamlines the placement of paraffin-embedded tissue sections onto slides. This compact and user-friendly unit is compatible with existing microtomes, improving workflow efficiency, section quality, and consistency. Aquaro Histology's products aim to support laboratory professionals in delivering better patient diagnoses and care.

RareCyte

Venture Round in 2017
RareCyte, Inc. is a life sciences company based in Seattle, Washington, founded in 2009. The company specializes in developing advanced platforms for liquid and tissue biopsy analysis, focusing on the detection and characterization of rare cells, particularly circulating tumor cells (CTCs) and circulating endothelial cells (CECs) in blood samples. RareCyte's AccuCyte system provides an open platform that facilitates the unbiased discovery and isolation of these rare cells, supporting various applications in cancer research, cardiovascular disease studies, and diagnostic development. The company offers a range of products, including sample preparation systems, staining kits, automated fluorescence microscopy instruments, and slide imaging systems. By enabling precision medicine approaches, RareCyte aims to provide new tools for medical professionals and researchers to address complex questions in the fields of cancer and other therapeutic areas.

Akoya Biosciences

Venture Round in 2017
Akoya Biosciences is a spatial biology company offering the most comprehensive, end-to-end solutions for high-parameter tissue analysis from discovery through clinical and translational research, enabling the development of more precise therapies for immuno-oncology and other drug development applications. The company has two industry-leading platforms that empower investigators and researchers to gain a deeper understanding of complex diseases such as cancer, and autoimmune or neurological disorders. The CODEX system is the only benchtop platform that can efficiently quantify more than 40 biomarkers and is ideally suited for biomarker discovery. The Phenoptics platform is the only end-to-end multiplexed immunofluorescence solution with the robustness and high throughput necessary for translational research and clinical trials.

Dynex Technologies

Acquisition in 2017
Dynex Technologies, Inc. is a designer and manufacturer based in Chantilly, Virginia, specializing in fully automated ELISA microplate workstations, laboratory instruments, and related consumables and accessories. Established in 1952 and formerly known as Dynatech Laboratories, the company focuses on integrating advanced detection methods with automated sample handling to enhance laboratory efficiency. Dynex's products support scientists and clinicians in making significant discoveries and achieving more accurate diagnoses, ultimately contributing to improved health outcomes. The company distributes its offerings through a network of distributors across the United States, Canada, Mexico, South America, Asia, Europe, the Middle East, and Africa, as well as through online channels. In addition to its product range, Dynex Technologies also provides technical support services to its clients, addressing their evolving laboratory needs.

Medpricer

Venture Round in 2017
Medpricer develops a purchased services cost management solution tailored for the healthcare industry. The company's flagship platform, mSource, enables healthcare providers to discover, organize, benchmark, and manage their spending on service providers effectively. By offering precision benchmark reports, project management, and advisory services, Medpricer helps healthcare organizations enhance visibility and control over their expenses. This approach can lead to significant improvements in operating margins, with potential savings of up to 5%. Founded in 2004 and headquartered in Guilford, Connecticut, Medpricer also has an office in Walnut Creek, California. As of October 2019, it operates as a subsidiary of Premier, Inc.

TrakCel

Venture Round in 2016
TrakCel Ltd. is a technology company based in Cardiff, United Kingdom, specializing in integrated solutions for the cell therapy supply chain, specifically for autologous and allogeneic therapies. Founded in 2012, TrakCel offers a comprehensive Cell Orchestration Platform, a cloud-based software solution that streamlines the development of cell and gene therapies. This platform enables users to collate, track, and document essential program information, enhancing efficiency and compliance throughout various stages of therapy development. TrakCel's technology supports medical centers, logistics providers, manufacturers, and therapy sponsors by facilitating regulatory audits and addressing the data management, reporting, and analysis needs of clinical trials. By providing a scalable and validated platform, TrakCel aims to modernize and optimize the processes involved in cell and gene therapy, thereby reducing the time, cost, and risks associated with traditional paper-based systems.

Precision NanoSystem

Series A in 2015
Precision Nanosystems specializes in the development of tools and processes for the creation and manufacturing of nanoparticles used in medicine and medical research. The company offers a range of products, including the NanoAssemblr benchtop instrument, which facilitates the prototyping of nanoparticles and the development of nanoparticle-based drugs that deliver RNA, small molecules, and protein therapeutics. Additionally, Precision Nanosystems provides various kits, such as Neuro9Kit for studying gene function in neurons and glial cells, Test9Kit for gene function studies in diverse cell types, and Hepato9Kit for liver gene function analysis. Their microfluidic devices enable the rapid and cost-effective manufacturing of lipid nanoparticles that can encapsulate and deliver bioactive agents, supporting life sciences researchers in developing innovative treatments and therapies for various diseases.

RareCyte

Venture Round in 2012
RareCyte, Inc. is a life sciences company based in Seattle, Washington, founded in 2009. The company specializes in developing advanced platforms for liquid and tissue biopsy analysis, focusing on the detection and characterization of rare cells, particularly circulating tumor cells (CTCs) and circulating endothelial cells (CECs) in blood samples. RareCyte's AccuCyte system provides an open platform that facilitates the unbiased discovery and isolation of these rare cells, supporting various applications in cancer research, cardiovascular disease studies, and diagnostic development. The company offers a range of products, including sample preparation systems, staining kits, automated fluorescence microscopy instruments, and slide imaging systems. By enabling precision medicine approaches, RareCyte aims to provide new tools for medical professionals and researchers to address complex questions in the fields of cancer and other therapeutic areas.

PneumRx

Venture Round in 2011
PneumRx, Inc. is a medical device company focused on developing minimally invasive treatments for patients with emphysema. Established in 2004 and based in Mountain View, California, the company is known for its investigational device, the RePneu Lung Volume Reduction Coil, which aims to improve lung function in individuals suffering from this chronic condition.

Estech

Series D in 2010
Estech, founded in 1996 by Arthur and Raymond Bertolero, is a privately held medical device manufacturing and distribution company based in San Ramon, California. The company specializes in developing and marketing medical devices and disposables for cardiac surgery, with a focus on least invasive products. Estech's global distribution network and commitment to innovation have attracted top professionals in the medical device industry. The company's success is attributed to the extensive experience and dedication of its team, which has enabled it to thrive in the competitive medical device market.

AltheaDx

Series A in 2010
AltheaDx, Inc. is a molecular diagnostics company based in San Diego, California, specializing in pharmacogenetics. The company utilizes an algorithm-based bioinformatics platform and a portfolio of pharmacogenetic testing products to assist healthcare providers in identifying the most suitable medications and dosage guidelines tailored to patients' genetic profiles and existing prescriptions. AltheaDx's IDgenetix test facilitates personalized therapeutic decisions for patients with common clinical conditions, including cardiovascular disease and neuropsychiatric disorders. Additionally, the company offers research and development services that encompass molecular biomarker discovery, assay development, and clinical trial testing, aimed at supporting diagnostic development for pharmaceutical, biotech, and medical device companies. AltheaDx serves a diverse range of clients, including long-term care facilities, government organizations, integrated delivery networks, and physicians. Founded in 1998, AltheaDx has established itself as a key player in the field of personalized medicine.

BioVentrix

Debt Financing in 2009
BioVentrix, Inc. is a medical device company based in San Ramon, California, that specializes in innovative treatments for congestive heart failure (CHF), particularly in patients with ischemic cardiomyopathy. Founded in 2003, the company has developed the Revivent Myocardial Anchoring System, which utilizes a hybrid closed-chest transcatheter procedure to enhance cardiac function. This device operates by restoring the size and volume of the left ventricle through the implantation of micro-anchoring pairs that effectively exclude scarred myocardium from healthy tissue. BioVentrix aims to provide less invasive, catheter-based solutions to improve patient outcomes and slow the progression of CHF, addressing a critical need in cardiac care.

Estech

Venture Round in 2009
Estech, founded in 1996 by Arthur and Raymond Bertolero, is a privately held medical device manufacturing and distribution company based in San Ramon, California. The company specializes in developing and marketing medical devices and disposables for cardiac surgery, with a focus on least invasive products. Estech's global distribution network and commitment to innovation have attracted top professionals in the medical device industry. The company's success is attributed to the extensive experience and dedication of its team, which has enabled it to thrive in the competitive medical device market.

Estech

Venture Round in 2008
Estech, founded in 1996 by Arthur and Raymond Bertolero, is a privately held medical device manufacturing and distribution company based in San Ramon, California. The company specializes in developing and marketing medical devices and disposables for cardiac surgery, with a focus on least invasive products. Estech's global distribution network and commitment to innovation have attracted top professionals in the medical device industry. The company's success is attributed to the extensive experience and dedication of its team, which has enabled it to thrive in the competitive medical device market.

Freedom Innovations LLC.

Funding Round in 2008
Freedom Innovations LLC specializes in the design and manufacture of prosthetic devices, focusing on lower limb solutions tailored for users with varying mobility levels, from low to high. The company offers a diverse range of prosthetic feet suitable for everyday walking and extreme sports, ensuring users can engage in a wide array of activities. Freedom Innovations collaborates closely with prosthetists and amputees to develop products that enhance the quality of life for individuals with disabilities, enabling them to lead more active and fulfilling lives.

Confirma

Series C in 2008
Confirma is the only company that develops and markets an MRI-CAD system, CADstream, revolutionizing MRI study analysis and reporting through automated and standardized processing. CADstream automates the analysis and interventional guidance of MRI studies, providing higher quality imaging studies, lower costs for radiology practices and improved communication tools for physicians and patients. CADstream can be integrated into any workflow scenario and is compatible with all MRI scanners and PACS.

Asuragen

Series B in 2007
Asuragen, Inc. is a molecular diagnostics company based in Austin, Texas, specializing in oncology and genetic disorders. Founded in 2005, the company develops and commercializes a diverse array of diagnostic products and services aimed at improving patient management. Its offerings include various AmplideX reagents for detecting genetic markers, as well as comprehensive cancer diagnostic kits, such as QUANTIDEX and Signature assays that target specific mutations and gene fusions. Asuragen employs its patented Armored RNA technology in its diagnostics portfolio, which encompasses genetic and oncology testing products alongside industry-leading controls. The company also provides GLP testing services and operates a cGMP manufacturing facility, ensuring a seamless process from discovery to commercialization. With a focus on enhancing treatment outcomes through precise data, Asuragen plays a critical role in the medical community's efforts to improve patient care in oncology and genetics.

AngioScore

Series E in 2007
AngioScore Inc. is a medical device company that specializes in the development, manufacturing, and marketing of innovative angioplasty catheters aimed at treating cardiovascular and vascular diseases. The company's flagship product, the AngioSculpt Scoring Balloon Catheter, is designed for use in both coronary and peripheral interventional markets. This device addresses the limitations of traditional angioplasty balloon catheters by integrating a semi-compliant balloon with a unique nitinol scoring element, enhancing the effectiveness of vascular interventions. AngioScore's focus on advancing endovascular therapy tools positions it as a key player in the medical device industry dedicated to improving patient outcomes in vascular treatments.

LDR Holding

Series C in 2007
LDR Holding Corporation is a medical device company specializing in the development and marketing of innovative implantable spine systems and instrumentation for surgical use. Founded in 2004 and headquartered in Austin, Texas, the company offers a diverse range of spinal surgery solutions, including cervical and lumbar artificial disc systems, pedicle screw systems, cervical cages, and synthetic bone substitutes, among others. LDR Holding's products are designed to address various spine disorders and are distributed through collaborations with surgeons and distributors in multiple countries, including Australia, Japan, and the United Kingdom. The company has expanded its global presence with additional offices in France, China, Brazil, and Germany, and it was formerly known as LDR Spine USA, Inc. prior to acquiring LDR Médical. LDR Holding is committed to advancing surgical technologies that enhance patient outcomes and support the surgeon community.

PneumRx

Series B in 2007
PneumRx, Inc. is a medical device company focused on developing minimally invasive treatments for patients with emphysema. Established in 2004 and based in Mountain View, California, the company is known for its investigational device, the RePneu Lung Volume Reduction Coil, which aims to improve lung function in individuals suffering from this chronic condition.

Althea Technologies

Series C in 2007
Althea Technologies is a provider of contract manufacturing services specifically tailored for the pharmaceutical and biotechnology industries. The company specializes in gene expression analysis utilizing eXpress Profiling technology, alongside quantitative PCR testing services. In addition to these analytical services, Althea Technologies offers cGMP drug product filling in both vials and syringes. The company also engages in the production of microbial-derived recombinant proteins and plasmid DNA, supporting the development and manufacturing needs of its clients.

Asuragen

Series A in 2006
Asuragen, Inc. is a molecular diagnostics company based in Austin, Texas, specializing in oncology and genetic disorders. Founded in 2005, the company develops and commercializes a diverse array of diagnostic products and services aimed at improving patient management. Its offerings include various AmplideX reagents for detecting genetic markers, as well as comprehensive cancer diagnostic kits, such as QUANTIDEX and Signature assays that target specific mutations and gene fusions. Asuragen employs its patented Armored RNA technology in its diagnostics portfolio, which encompasses genetic and oncology testing products alongside industry-leading controls. The company also provides GLP testing services and operates a cGMP manufacturing facility, ensuring a seamless process from discovery to commercialization. With a focus on enhancing treatment outcomes through precise data, Asuragen plays a critical role in the medical community's efforts to improve patient care in oncology and genetics.

AngioScore

Series D in 2006
AngioScore Inc. is a medical device company that specializes in the development, manufacturing, and marketing of innovative angioplasty catheters aimed at treating cardiovascular and vascular diseases. The company's flagship product, the AngioSculpt Scoring Balloon Catheter, is designed for use in both coronary and peripheral interventional markets. This device addresses the limitations of traditional angioplasty balloon catheters by integrating a semi-compliant balloon with a unique nitinol scoring element, enhancing the effectiveness of vascular interventions. AngioScore's focus on advancing endovascular therapy tools positions it as a key player in the medical device industry dedicated to improving patient outcomes in vascular treatments.

Accumetrics

Series B in 2004
Accumetrics is a privately-held company based in San Diego, California, that specializes in the development, manufacturing, and marketing of the VerifyNow System, a suite of assays designed to assess platelet function. Founded in 1996, Accumetrics initially sold to Radiometer in 2000, but was repurchased by its management and investors in 2003. The VerifyNow System allows for the measurement of individual responses to various antiplatelet agents, providing critical diagnostic instrumentation and test kits that support clinicians in personalizing antiplatelet therapy for improved patient outcomes.

Estech

Series B in 2003
Estech, founded in 1996 by Arthur and Raymond Bertolero, is a privately held medical device manufacturing and distribution company based in San Ramon, California. The company specializes in developing and marketing medical devices and disposables for cardiac surgery, with a focus on least invasive products. Estech's global distribution network and commitment to innovation have attracted top professionals in the medical device industry. The company's success is attributed to the extensive experience and dedication of its team, which has enabled it to thrive in the competitive medical device market.
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