Eloxx
Eloxx Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Waltham, Massachusetts, specializing in the development of novel drugs targeting rare and ultra-rare genetic diseases caused by nonsense mutations. Founded in 2013, the company is focused on discovering and commercializing ribonucleic acid modulating drug candidates. Its lead investigational product, ELX-02, is currently undergoing Phase 2 clinical trials aimed at treating cystic fibrosis and nephropathic cystinosis in patients with specific nonsense mutations. Eloxx utilizes its advanced technology platform to create oral small molecules that can induce ribosomal readthrough, thereby enabling the production of full-length functional proteins. The company is building a robust pipeline of therapeutic candidates designed to address various genetic disorders, including Duchenne Muscular Dystrophy and Tay-Sachs syndrome, by overcoming the limitations posed by premature stop codons.
Zikani Therapeutics
Acquisition in 2021
Zikani Therapeutics, Inc. is focused on developing and commercializing innovative therapeutics for patients facing limited treatment options. The company utilizes its TURBO-ZM platform to create novel ribosome modulating agents (RMAs) aimed at addressing a variety of conditions, including cystic fibrosis, familial adenomatous polyposis, APC mutant colon cancer, recessive dystrophic epidermolysis bullosa, rare cancers, and other rare genetic diseases. Additionally, Zikani is developing antibiotic compounds that target serious, multi-drug resistant gram-negative infections, an area where existing treatments are often inadequate. Founded in 2014 and initially known as Macrolide Pharmaceuticals, the company is headquartered in Watertown, Massachusetts. Through its advancements in synthetic chemistry and microbiology, Zikani Therapeutics seeks to enhance patient recovery and improve outcomes in challenging medical scenarios.
Sevion Therapeutics
Acquisition in 2017
Sevion Therapeutics is a biopharmaceutical company focused on discovering, developing, and acquiring innovative therapies for cancer and immunological diseases. The company advances a pipeline of proprietary and partnered product candidates utilizing its unique antibody technology platforms. This pipeline aims to create biologic therapies targeting previously inaccessible areas, including multispanning membrane proteins and ion channels involved in various diseases. Additionally, Sevion has developed a pioneering protein nanocage system designed for the targeted delivery of nucleic acids and other therapeutic payloads to specific cells. Through its research and development efforts, Sevion is dedicated to addressing critical therapeutic needs in the treatment of cancer and inflammatory diseases.
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