IndieBio

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

Founded in 2023, AlkaLi Labs is a biotechnology company based in San Francisco. It specializes in recovering critical minerals like lithium and cobalt from industrial waste streams using bioengineering solutions.

Founded in 2022 and headquartered in Berkeley, California, Laguna Bio develops a drug discovery platform designed to selectively activate and expand the innate immune system against cancer. The company focuses on providing a specific type of T cell for the immune system to fight solid tumors by increasing the response rate of bispecific antibody drugs.

Founded in 2021, Sóliome is a biotechnology company based in San Francisco, California. It specializes in developing protein-based sunscreens that are safe and effective, using molecules naturally produced by the human body to protect against harmful UV rays.

Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on cultivating marine-animal cells to create sustainable fish and seafood alternatives, including bluefin tuna. Finless Foods aims to provide a variety of food options that cater to diverse tastes and dietary preferences while promoting responsible production practices. By offering accessible plant-based and cell-cultured seafood alternatives, the company seeks to contribute to better ocean health and foster a more sustainable future for food consumption.

California Cultured is a food company based in Davis, California, that specializes in creating sustainable, lab-grown cocoa and coffee through advanced cellular agriculture techniques. Founded in 2020, the company focuses on producing cocoa that is less bitter and requires less sugar, while also ensuring its products are healthier for consumers. By stimulating cocoa cell growth using common food ingredients, California Cultured aims to provide high-quality cocoa products that are free from the ethical issues traditionally associated with cocoa production, such as slavery and deforestation. This innovative approach allows customers to enjoy delicious and sustainable cocoa without the environmental and social drawbacks of conventional methods.

Avisa Myko is a biotechnology company based in San Francisco, California. It specializes in the production of melanin, a natural pigment with applications in cosmetics, biomedicine, organic semiconductors, biosensors, and latex products. The company's patented technology enables large-scale production of soluble, affordable melanin, offering protection against ionizing radiation and contributing to better health and environmental sustainability.

Founded in 2013, ZymoChem develops eco-friendly chemical production processes using engineered microbes. These processes convert renewable feedstocks like sugars into industrial chemicals, minimizing carbon loss and enabling cost-competitive bio-based manufacturing.

Chronus Health develops a portable diagnostic device for delivering point-of-care lab results in minutes. Its device enables real-time diagnosis at the point-of-care, improving time to care and patient outcomes.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

Founded in 2014, QuantumCyte develops an automated tissue dissection system that uses digital maps to isolate regions of interest containing informative biomarkers. This platform aims to improve cancer outcomes by enabling precise cellular data analysis for predicting drug efficacy.

Avisa Myko is a biotechnology company based in San Francisco, California. It specializes in the production of melanin, a natural pigment with applications in cosmetics, biomedicine, organic semiconductors, biosensors, and latex products. The company's patented technology enables large-scale production of soluble, affordable melanin, offering protection against ionizing radiation and contributing to better health and environmental sustainability.

California Cultured is a food company based in Davis, California, that specializes in creating sustainable, lab-grown cocoa and coffee through advanced cellular agriculture techniques. Founded in 2020, the company focuses on producing cocoa that is less bitter and requires less sugar, while also ensuring its products are healthier for consumers. By stimulating cocoa cell growth using common food ingredients, California Cultured aims to provide high-quality cocoa products that are free from the ethical issues traditionally associated with cocoa production, such as slavery and deforestation. This innovative approach allows customers to enjoy delicious and sustainable cocoa without the environmental and social drawbacks of conventional methods.

Founded in 2023, AlkaLi Labs is a biotechnology company based in San Francisco. It specializes in recovering critical minerals like lithium and cobalt from industrial waste streams using bioengineering solutions.

Geltor designs and produces animal-free collagen and other bioactive proteins for beauty, wellness, and nutrition applications. Founded in 2015, the company uses proprietary AI to create customized proteins tailored to specific industry needs.

Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative gene therapy treatments for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes advanced oral lipid nanoparticle technology to deliver mRNA and plasmid DNA directly to intestinal stem cells. This approach aims to address the root causes of gastrointestinal diseases, including Familial Adenomatous Polyposis (FAP), a hereditary condition that can lead to colorectal cancer and often necessitates invasive surgical interventions. DNALite's therapies seek to transform protein biologics into oral drugs, allowing for more effective and less invasive treatment options.

Michroma is a biotech company that develops natural, thermostable colorants for fungus-based food and cosmetics by leveraging fermentation of filamentous fungi and synthetic biology. It aims to replace synthetic pigments with natural pigments produced through biotechnological fermentation, delivering pH- and heat-stable colorants at scale for food and cosmetic applications. The company operates in multiple locations, including San Francisco, United States, and Rosario, Argentina, and pursues scalable production in bioreactors using proprietary fungal strains.

Founded in 2020, Prolific Machines is a San Francisco-based biotech company dedicated to revolutionizing cell production for a sustainable future. It combines advanced technologies to enable large-scale cell manufacturing, aiming to improve therapeutic protein production for biotechnology and pharmaceutical companies.

Founded in 2019, Aja Labs is a biotechnology company based in San Francisco. It specializes in producing biodegradable fiber derived from plants, designed to resemble human hair for use in hair extensions. This innovative approach aims to replace plastic-based fibers and reduce the reliance on chemical-heavy synthetics or human hair.

OneSkin is a biotechnology company focused on skin aging and longevity that develops testing platforms and consumer products. It uses animal-free three-dimensional human skin models to evaluate the safety and efficacy of cosmetic ingredients and anti-aging compounds, supporting research and validation for the cosmetic and ingredient supplier industries. The company has developed a proprietary peptide, OS-01, intended to reduce skin biological age by decreasing the accumulation of aged cells, improving cellular repair, and strengthening the epidermal barrier. Its consumer offering includes a vegan topical product based on OS-01 designed for all skin types, marketed through its website. The business combines in vitro testing services with product development to address root causes of skin aging and support proper skin cell function.

Michroma is a biotech company that develops natural, thermostable colorants for fungus-based food and cosmetics by leveraging fermentation of filamentous fungi and synthetic biology. It aims to replace synthetic pigments with natural pigments produced through biotechnological fermentation, delivering pH- and heat-stable colorants at scale for food and cosmetic applications. The company operates in multiple locations, including San Francisco, United States, and Rosario, Argentina, and pursues scalable production in bioreactors using proprietary fungal strains.

Founded in 2022 and headquartered in Berkeley, California, Laguna Bio develops a drug discovery platform designed to selectively activate and expand the innate immune system against cancer. The company focuses on providing a specific type of T cell for the immune system to fight solid tumors by increasing the response rate of bispecific antibody drugs.

Melio is a healthcare company based in Santa Clara, California, specializing in blood testing technology aimed at detecting prevalent infections. The company has developed a comprehensive blood test platform that identifies common pathogens responsible for bloodstream infections. Utilizing a patented melting technique followed by detailed analysis, Melio's technology enables quick and accurate identification of blood-based pathogens. This innovation allows healthcare providers to deliver timely and targeted treatment, addressing the urgent need for effective therapies while also contributing to the fight against antibiotic resistance.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

SyntheX specializes in drug discovery using synthetic biology platforms. It identifies protein interaction modulators and enables functional protein degradation, focusing on unique mechanisms for cancer and rare disease treatments.

BioLumen is a nutritional technology company that develops a patented dietary fiber technology platform that reduces the negative effect of a diet heavy in processed foods. BioLumen's technology is composed of insoluble dietary fiber matrix covered with a blend of food ingredients created from the latest drug delivery system research. The company's product, a nutraceutical, focuses on high risk individuals with prediabetes to help manage blood sugar levels, protect their liver from excess sugar and feed their gut microbiome, delivering health benefits. BioLumen was founded on 2018 and is headquartered in San Francisco, California.

UPSIDE Foods, formerly known as Memphis Meats, is a cultivated meat company founded in 2015 and headquartered in Berkeley, California. The company specializes in producing real meat, poultry, and seafood directly from animal cells, eliminating the need to raise and slaughter animals. This innovative approach significantly reduces the resource consumption associated with traditional meat production, requiring less water, land, and energy. UPSIDE Foods aims to offer consumers clean, humane, and sustainable meat products, such as beef meatballs, chicken, and duck, all grown in controlled environments. The company is led by Dr. Uma Valeti, who is committed to transforming the food industry with healthier and environmentally friendly alternatives to conventional meat.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative gene therapy treatments for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes advanced oral lipid nanoparticle technology to deliver mRNA and plasmid DNA directly to intestinal stem cells. This approach aims to address the root causes of gastrointestinal diseases, including Familial Adenomatous Polyposis (FAP), a hereditary condition that can lead to colorectal cancer and often necessitates invasive surgical interventions. DNALite's therapies seek to transform protein biologics into oral drugs, allowing for more effective and less invasive treatment options.

Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on cultivating marine-animal cells to create sustainable fish and seafood alternatives, including bluefin tuna. Finless Foods aims to provide a variety of food options that cater to diverse tastes and dietary preferences while promoting responsible production practices. By offering accessible plant-based and cell-cultured seafood alternatives, the company seeks to contribute to better ocean health and foster a more sustainable future for food consumption.

Founded in 2014, QuantumCyte develops an automated tissue dissection system that uses digital maps to isolate regions of interest containing informative biomarkers. This platform aims to improve cancer outcomes by enabling precise cellular data analysis for predicting drug efficacy.

Avisa Myko is a biotechnology company based in San Francisco, California. It specializes in the production of melanin, a natural pigment with applications in cosmetics, biomedicine, organic semiconductors, biosensors, and latex products. The company's patented technology enables large-scale production of soluble, affordable melanin, offering protection against ionizing radiation and contributing to better health and environmental sustainability.

Founded in 2021, Sóliome is a biotechnology company based in San Francisco, California. It specializes in developing protein-based sunscreens that are safe and effective, using molecules naturally produced by the human body to protect against harmful UV rays.

Founded in 2021, Sóliome is a biotechnology company based in San Francisco, California. It specializes in developing protein-based sunscreens that are safe and effective, using molecules naturally produced by the human body to protect against harmful UV rays.

Founded in 2013, ZymoChem develops eco-friendly chemical production processes using engineered microbes. These processes convert renewable feedstocks like sugars into industrial chemicals, minimizing carbon loss and enabling cost-competitive bio-based manufacturing.

Founded in 2014, Lingrove specializes in manufacturing eco-friendly bio-composite materials. Utilizing a proprietary process, they produce high-performance natural fiber composites from plant-based fibers and resins, aiming to reduce deforestation and embodied carbon in industries such as commercial interiors, transportation, and construction.

Founded in 2018, New Culture is a food company based in San Francisco, California. It specializes in producing sustainable, animal-free cheese using microflora to create dairy proteins.

Sundial Foods develops plant-based meat alternatives designed to replicate the texture, appearance, and sensory experience of traditional meat using natural, plant-derived ingredients. The company aims to offer affordable, nutritious options for conscious consumers and to reduce meat consumption without relying on synthetic additives or heavily processed ingredients. Based in Berkeley, California, Sundial Foods was founded in 2019.

Prothegen is a biotechnology company located in Palo Alto, California, focused on developing innovative medicines that precisely regulate cell death. The company has created a platform aimed at delivering therapies that can either inhibit or promote ferroptosis, a form of regulated cell death. By targeting this mechanism, Prothegen seeks to provide effective therapeutics that can prevent unwanted cell death, thereby improving treatment options for various diseases.

Prothegen is a biotechnology company located in Palo Alto, California, focused on developing innovative medicines that precisely regulate cell death. The company has created a platform aimed at delivering therapies that can either inhibit or promote ferroptosis, a form of regulated cell death. By targeting this mechanism, Prothegen seeks to provide effective therapeutics that can prevent unwanted cell death, thereby improving treatment options for various diseases.

California Cultured is a food company based in Davis, California, that specializes in creating sustainable, lab-grown cocoa and coffee through advanced cellular agriculture techniques. Founded in 2020, the company focuses on producing cocoa that is less bitter and requires less sugar, while also ensuring its products are healthier for consumers. By stimulating cocoa cell growth using common food ingredients, California Cultured aims to provide high-quality cocoa products that are free from the ethical issues traditionally associated with cocoa production, such as slavery and deforestation. This innovative approach allows customers to enjoy delicious and sustainable cocoa without the environmental and social drawbacks of conventional methods.

Indee Labs develops hardware and platform technologies for gene delivery to immune cells, with the aim of enabling the rapid development and scalable manufacture of gene-modified cell therapies, including CAR-T cells. The company focuses on non-viral delivery methods to introduce small molecules, nucleic acids, proteins, and gene-editing complexes into immune cells, supporting biopharmaceutical research and manufacturing while maintaining high cell viability and function. Its technology has progressed with collaboration from national facilities and through participation in biotech incubators and accelerators. Indee Labs maintains an international footprint, with an office in Sydney and lab space in Berkeley, reflecting its cross-regional development and manufacturing focus.

Khepra is a company based in San Francisco, California, that specializes in converting plastics and agricultural waste into renewable fuels and chemicals. Utilizing proprietary technology, Khepra employs ultrasonic methods, including frictive heating, cavitation, and acoustic pressure, to break down waste streams without extraction, thus preserving their integrity. This innovative, electrified process leverages excess renewable electricity, particularly from solar and wind sources, during periods of energy curtailment. By transforming waste into valuable resources, Khepra aims to support industries in adopting clean energy solutions and contribute to a sustainable future.

Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on cultivating marine-animal cells to create sustainable fish and seafood alternatives, including bluefin tuna. Finless Foods aims to provide a variety of food options that cater to diverse tastes and dietary preferences while promoting responsible production practices. By offering accessible plant-based and cell-cultured seafood alternatives, the company seeks to contribute to better ocean health and foster a more sustainable future for food consumption.

Filtricine, Inc., founded in 2017 and based in Santa Clara, California, is a clinical-stage biotechnology company focused on developing innovative therapies for cancer treatment. The company's approach involves targeted nutrient deprivation, which identifies and exploits metabolic vulnerabilities specific to cancer cells. By depleting nutrients critical to cancer growth without using traditional drugs, Filtricine aims to provide effective treatments that minimize harm to healthy cells.

Founded in 2014, QuantumCyte develops an automated tissue dissection system that uses digital maps to isolate regions of interest containing informative biomarkers. This platform aims to improve cancer outcomes by enabling precise cellular data analysis for predicting drug efficacy.

Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.

Sundial Foods develops plant-based meat alternatives designed to replicate the texture, appearance, and sensory experience of traditional meat using natural, plant-derived ingredients. The company aims to offer affordable, nutritious options for conscious consumers and to reduce meat consumption without relying on synthetic additives or heavily processed ingredients. Based in Berkeley, California, Sundial Foods was founded in 2019.

Sundial Foods develops plant-based meat alternatives designed to replicate the texture, appearance, and sensory experience of traditional meat using natural, plant-derived ingredients. The company aims to offer affordable, nutritious options for conscious consumers and to reduce meat consumption without relying on synthetic additives or heavily processed ingredients. Based in Berkeley, California, Sundial Foods was founded in 2019.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative gene therapy treatments for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes advanced oral lipid nanoparticle technology to deliver mRNA and plasmid DNA directly to intestinal stem cells. This approach aims to address the root causes of gastrointestinal diseases, including Familial Adenomatous Polyposis (FAP), a hereditary condition that can lead to colorectal cancer and often necessitates invasive surgical interventions. DNALite's therapies seek to transform protein biologics into oral drugs, allowing for more effective and less invasive treatment options.

Founded in 2020, Prolific Machines is a San Francisco-based biotech company dedicated to revolutionizing cell production for a sustainable future. It combines advanced technologies to enable large-scale cell manufacturing, aiming to improve therapeutic protein production for biotechnology and pharmaceutical companies.

Chronus Health develops a portable diagnostic device for delivering point-of-care lab results in minutes. Its device enables real-time diagnosis at the point-of-care, improving time to care and patient outcomes.

Founded in 2019, Aja Labs is a biotechnology company based in San Francisco. It specializes in producing biodegradable fiber derived from plants, designed to resemble human hair for use in hair extensions. This innovative approach aims to replace plastic-based fibers and reduce the reliance on chemical-heavy synthetics or human hair.

Dalton Bioanalytics is a company that specializes in analytical technology aimed at transforming blood analysis and enhancing preventative healthcare. Founded in 2019 and based in Los Angeles, California, Dalton Bioanalytics addresses the inefficiencies and high costs associated with traditional laboratory testing. Its innovative technology digitizes the biochemical composition of blood, allowing for a comprehensive array of health insights derived from a single assay. This capability enables the monitoring of various plasma analytes, including proteins, lipids, electrolytes, and small molecules. By deciphering the biochemical signatures in blood, Dalton Bioanalytics supports the scientific research community in exploring multi-omic biology, thereby facilitating the discovery, development, and delivery of precision medicine.

California Cultured is a food company based in Davis, California, that specializes in creating sustainable, lab-grown cocoa and coffee through advanced cellular agriculture techniques. Founded in 2020, the company focuses on producing cocoa that is less bitter and requires less sugar, while also ensuring its products are healthier for consumers. By stimulating cocoa cell growth using common food ingredients, California Cultured aims to provide high-quality cocoa products that are free from the ethical issues traditionally associated with cocoa production, such as slavery and deforestation. This innovative approach allows customers to enjoy delicious and sustainable cocoa without the environmental and social drawbacks of conventional methods.

Founded in 2014, Lingrove specializes in manufacturing eco-friendly bio-composite materials. Utilizing a proprietary process, they produce high-performance natural fiber composites from plant-based fibers and resins, aiming to reduce deforestation and embodied carbon in industries such as commercial interiors, transportation, and construction.

Microgenesis is a biotechnology company focused on fertility and pregnancy health monitoring. It has developed a platform that provides a non-invasive fertility test and personalized nutritional supplementation aimed at restoring women's fertility potential. The company's innovative diagnostic approach detects subclinical inflammation that negatively impacts ovarian function and implantation, specifically targeting women who have experienced challenges, including multiple failed IVF attempts. Operating out of a CLIA lab in Oakland, Microgenesis offers its solutions through OB-GYNs and direct-to-consumer channels. Additionally, the platform addresses imbalances in vaginal and intestinal microbiota linked to infertility and offers dual testing for immunological issues related to the endometrium, equipping patients with effective treatment options for complex reproductive health cases.

SyntheX specializes in drug discovery using synthetic biology platforms. It identifies protein interaction modulators and enables functional protein degradation, focusing on unique mechanisms for cancer and rare disease treatments.

Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on cultivating marine-animal cells to create sustainable fish and seafood alternatives, including bluefin tuna. Finless Foods aims to provide a variety of food options that cater to diverse tastes and dietary preferences while promoting responsible production practices. By offering accessible plant-based and cell-cultured seafood alternatives, the company seeks to contribute to better ocean health and foster a more sustainable future for food consumption.

OneSkin is a biotechnology company focused on skin aging and longevity that develops testing platforms and consumer products. It uses animal-free three-dimensional human skin models to evaluate the safety and efficacy of cosmetic ingredients and anti-aging compounds, supporting research and validation for the cosmetic and ingredient supplier industries. The company has developed a proprietary peptide, OS-01, intended to reduce skin biological age by decreasing the accumulation of aged cells, improving cellular repair, and strengthening the epidermal barrier. Its consumer offering includes a vegan topical product based on OS-01 designed for all skin types, marketed through its website. The business combines in vitro testing services with product development to address root causes of skin aging and support proper skin cell function.

Founded in 2020, Advanced Microbubbles specializes in developing microbubble technology for targeted drug delivery. Utilizing ultrasound, the company's products temporarily open barriers like the blood-brain barrier to facilitate local drug entry, enhancing precision and reducing side effects.

Founded in 2020, Advanced Microbubbles specializes in developing microbubble technology for targeted drug delivery. Utilizing ultrasound, the company's products temporarily open barriers like the blood-brain barrier to facilitate local drug entry, enhancing precision and reducing side effects.

Khepra is a company based in San Francisco, California, that specializes in converting plastics and agricultural waste into renewable fuels and chemicals. Utilizing proprietary technology, Khepra employs ultrasonic methods, including frictive heating, cavitation, and acoustic pressure, to break down waste streams without extraction, thus preserving their integrity. This innovative, electrified process leverages excess renewable electricity, particularly from solar and wind sources, during periods of energy curtailment. By transforming waste into valuable resources, Khepra aims to support industries in adopting clean energy solutions and contribute to a sustainable future.

Khepra is a company based in San Francisco, California, that specializes in converting plastics and agricultural waste into renewable fuels and chemicals. Utilizing proprietary technology, Khepra employs ultrasonic methods, including frictive heating, cavitation, and acoustic pressure, to break down waste streams without extraction, thus preserving their integrity. This innovative, electrified process leverages excess renewable electricity, particularly from solar and wind sources, during periods of energy curtailment. By transforming waste into valuable resources, Khepra aims to support industries in adopting clean energy solutions and contribute to a sustainable future.

Convalesce Inc. is a San Francisco-based company that focuses on developing stem cell-based therapies for neurological disorders characterized by neuronal degeneration, such as Parkinson's disease. Founded in 2018, Convalesce specializes in creating implantable biomaterials designed to enhance stem cell therapy effectiveness. These innovative biomaterials address critical challenges related to the survival and differentiation of stem cells into neurons after implantation. By leveraging advanced biomaterials, the company aims to enable medical professionals to regenerate lost neuronal networks in patients suffering from neurodegenerative conditions, ultimately improving treatment outcomes.

Dalton Bioanalytics is a company that specializes in analytical technology aimed at transforming blood analysis and enhancing preventative healthcare. Founded in 2019 and based in Los Angeles, California, Dalton Bioanalytics addresses the inefficiencies and high costs associated with traditional laboratory testing. Its innovative technology digitizes the biochemical composition of blood, allowing for a comprehensive array of health insights derived from a single assay. This capability enables the monitoring of various plasma analytes, including proteins, lipids, electrolytes, and small molecules. By deciphering the biochemical signatures in blood, Dalton Bioanalytics supports the scientific research community in exploring multi-omic biology, thereby facilitating the discovery, development, and delivery of precision medicine.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

Circularis Biotechnologies, Inc. is a biotechnology company founded in 2014 and headquartered in Oakland, California. The company specializes in developing innovative methods to regulate gene expression, which enhances the production yields of biotherapeutics. Circularis offers a range of products, including RACRE Variant Libraries, hCMV Variant Library, Protein expression with CMV promoters, and T7 Variant Library. In addition, it provides various services such as RACRE Enhancement, RACRE Discovery, RACRE Technology Access Program, and Ribozyme Analysis of Cis-Regulatory Elements. Through its advanced technologies and services, Circularis aims to improve the efficiency and effectiveness of biotherapeutic production.

CASPR Biotech is a San Francisco-based company established in 2018 that specializes in the development of a CRISPR-based platform for diagnosing antimicrobial resistances (AMR) and infectious diseases. The company focuses on creating portable diagnostic kits that utilize proprietary CRISPR Cas enzymes to detect specific DNA and RNA sequences, as well as signature amino acid sequences associated with infectious diseases and genetic mutations. These kits are designed to provide clinicians with a simple, fast, and affordable solution for molecular detection, enhancing the efficiency of disease identification in clinical and hospital settings.

CASPR Biotech is a San Francisco-based company established in 2018 that specializes in the development of a CRISPR-based platform for diagnosing antimicrobial resistances (AMR) and infectious diseases. The company focuses on creating portable diagnostic kits that utilize proprietary CRISPR Cas enzymes to detect specific DNA and RNA sequences, as well as signature amino acid sequences associated with infectious diseases and genetic mutations. These kits are designed to provide clinicians with a simple, fast, and affordable solution for molecular detection, enhancing the efficiency of disease identification in clinical and hospital settings.

UPSIDE Foods, formerly known as Memphis Meats, is a cultivated meat company founded in 2015 and headquartered in Berkeley, California. The company specializes in producing real meat, poultry, and seafood directly from animal cells, eliminating the need to raise and slaughter animals. This innovative approach significantly reduces the resource consumption associated with traditional meat production, requiring less water, land, and energy. UPSIDE Foods aims to offer consumers clean, humane, and sustainable meat products, such as beef meatballs, chicken, and duck, all grown in controlled environments. The company is led by Dr. Uma Valeti, who is committed to transforming the food industry with healthier and environmentally friendly alternatives to conventional meat.

Chronus Health develops a portable diagnostic device for delivering point-of-care lab results in minutes. Its device enables real-time diagnosis at the point-of-care, improving time to care and patient outcomes.

BioLumen is a nutritional technology company that develops a patented dietary fiber technology platform that reduces the negative effect of a diet heavy in processed foods. BioLumen's technology is composed of insoluble dietary fiber matrix covered with a blend of food ingredients created from the latest drug delivery system research. The company's product, a nutraceutical, focuses on high risk individuals with prediabetes to help manage blood sugar levels, protect their liver from excess sugar and feed their gut microbiome, delivering health benefits. BioLumen was founded on 2018 and is headquartered in San Francisco, California.

Primitives is a San Francisco-based company engineering advanced biomaterials to reduce food waste and plastics pollution.

Primitives is a San Francisco-based company engineering advanced biomaterials to reduce food waste and plastics pollution.

Blue Planet Ecosystems develops and operates modular closed-loop photoprotein reactors for sustainable food production in extreme environments. The company designs self-sustaining aquaculture systems powered by renewable energy that convert carbon dioxide and sunlight into sugars, amino and fatty acids, making nutrients available for zooplankton and fish. Its technology enables organic seafood production close to consumers on nontraditional farming sites, helping farmers and agricultural businesses diversify production in response to climate change. Founded in 2018 and based in San Francisco, Blue Planet Ecosystems focuses on pollutant-free, high-quality aquaculture with minimal environmental impact by turning sunlight into feed and enabling new farming methods.

Michroma is a biotech company that develops natural, thermostable colorants for fungus-based food and cosmetics by leveraging fermentation of filamentous fungi and synthetic biology. It aims to replace synthetic pigments with natural pigments produced through biotechnological fermentation, delivering pH- and heat-stable colorants at scale for food and cosmetic applications. The company operates in multiple locations, including San Francisco, United States, and Rosario, Argentina, and pursues scalable production in bioreactors using proprietary fungal strains.

Avisa Myko is a biotechnology company based in San Francisco, California. It specializes in the production of melanin, a natural pigment with applications in cosmetics, biomedicine, organic semiconductors, biosensors, and latex products. The company's patented technology enables large-scale production of soluble, affordable melanin, offering protection against ionizing radiation and contributing to better health and environmental sustainability.

Dalton Bioanalytics is a company that specializes in analytical technology aimed at transforming blood analysis and enhancing preventative healthcare. Founded in 2019 and based in Los Angeles, California, Dalton Bioanalytics addresses the inefficiencies and high costs associated with traditional laboratory testing. Its innovative technology digitizes the biochemical composition of blood, allowing for a comprehensive array of health insights derived from a single assay. This capability enables the monitoring of various plasma analytes, including proteins, lipids, electrolytes, and small molecules. By deciphering the biochemical signatures in blood, Dalton Bioanalytics supports the scientific research community in exploring multi-omic biology, thereby facilitating the discovery, development, and delivery of precision medicine.

Pando Nutrition, Inc., founded in 2017 and headquartered in San Francisco, California, is an animal microbiome company focused on developing probiotics to promote livestock health and performance without relying on medically significant drugs. The company's primary goal is to address the antibiotic resistance crisis by engineering genetically modified probiotics that enhance feed efficiency, profitability, and methane emission control. Pando Nutrition offers Panbiotics, a platform designed to identify and manage methane emissions, thereby improving feed efficiency and livestock growth. Additionally, the company develops solutions for poultry pathogens like Coccidiosis and operates in the sustainable protein sector using yeast-based systems for animal feed.

Founded in 2011, Dahlia Biosciences is a biotechnology company specializing in single-cell RNA analysis tools for research and diagnostic applications. It uses CRISPR-Cas9 technology to detect multiple DNA and RNA biomarkers directly in cells and tissues.

Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative gene therapy treatments for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes advanced oral lipid nanoparticle technology to deliver mRNA and plasmid DNA directly to intestinal stem cells. This approach aims to address the root causes of gastrointestinal diseases, including Familial Adenomatous Polyposis (FAP), a hereditary condition that can lead to colorectal cancer and often necessitates invasive surgical interventions. DNALite's therapies seek to transform protein biologics into oral drugs, allowing for more effective and less invasive treatment options.

Founded in 2014, QuantumCyte develops an automated tissue dissection system that uses digital maps to isolate regions of interest containing informative biomarkers. This platform aims to improve cancer outcomes by enabling precise cellular data analysis for predicting drug efficacy.

Chronus Health develops a portable diagnostic device for delivering point-of-care lab results in minutes. Its device enables real-time diagnosis at the point-of-care, improving time to care and patient outcomes.

The EVERY Company, formerly known as Clara Foods, specializes in producing animal-free proteins for the food and beverage industry. Founded in 2014 and based in South San Francisco, California, the company utilizes advanced fermentation technology to create functional and nutritional proteins derived from microorganisms. Its product line includes baking ingredients, nutritional supplements, and egg white alternatives that are free from pathogens and suitable for various culinary applications, such as cakes and meringues. The EVERY Company aims to provide a sustainable, healthier, and kinder alternative to traditional animal agriculture by decoupling protein production from animals, thereby offering consumers healthy and affordable protein options without added sugars.

Founded in 2018, New Culture is a food company based in San Francisco, California. It specializes in producing sustainable, animal-free cheese using microflora to create dairy proteins.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

CASPR Biotech is a San Francisco-based company established in 2018 that specializes in the development of a CRISPR-based platform for diagnosing antimicrobial resistances (AMR) and infectious diseases. The company focuses on creating portable diagnostic kits that utilize proprietary CRISPR Cas enzymes to detect specific DNA and RNA sequences, as well as signature amino acid sequences associated with infectious diseases and genetic mutations. These kits are designed to provide clinicians with a simple, fast, and affordable solution for molecular detection, enhancing the efficiency of disease identification in clinical and hospital settings.

Guided Clarity, Inc., established in 2018 and headquartered in San Francisco, California, specializes in the development and manufacturing of bioactive peptides designed to enhance mitochondrial health. The company focuses on creating medical food products that isolate specific bioactive proteins known for their mitochondrial renewing properties, targeting the aging population.

Filtricine, Inc., founded in 2017 and based in Santa Clara, California, is a clinical-stage biotechnology company focused on developing innovative therapies for cancer treatment. The company's approach involves targeted nutrient deprivation, which identifies and exploits metabolic vulnerabilities specific to cancer cells. By depleting nutrients critical to cancer growth without using traditional drugs, Filtricine aims to provide effective treatments that minimize harm to healthy cells.

Geltor designs and produces animal-free collagen and other bioactive proteins for beauty, wellness, and nutrition applications. Founded in 2015, the company uses proprietary AI to create customized proteins tailored to specific industry needs.

Founded in 2011, Dahlia Biosciences is a biotechnology company specializing in single-cell RNA analysis tools for research and diagnostic applications. It uses CRISPR-Cas9 technology to detect multiple DNA and RNA biomarkers directly in cells and tissues.

Prime Roots is a San Francisco-based company founded in 2017 that specializes in producing plant-based food products as alternatives to meat and seafood. The company utilizes natural koji proteins derived from fungi to create vegetarian-based super protein foods, such as salmon burgers, which mimic the taste, texture, and nutritional value of animal-derived products. By offering these alternatives, Prime Roots aims to reduce carbon-intensive reliance on animals and provide both meat-eaters and vegans with access to protein-rich food options. The company also organizes food events for its members and serves the broader food sector.

Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.

Convalesce Inc. is a San Francisco-based company that focuses on developing stem cell-based therapies for neurological disorders characterized by neuronal degeneration, such as Parkinson's disease. Founded in 2018, Convalesce specializes in creating implantable biomaterials designed to enhance stem cell therapy effectiveness. These innovative biomaterials address critical challenges related to the survival and differentiation of stem cells into neurons after implantation. By leveraging advanced biomaterials, the company aims to enable medical professionals to regenerate lost neuronal networks in patients suffering from neurodegenerative conditions, ultimately improving treatment outcomes.

Chronus Health develops a portable diagnostic device for delivering point-of-care lab results in minutes. Its device enables real-time diagnosis at the point-of-care, improving time to care and patient outcomes.

Filtricine, Inc., founded in 2017 and based in Santa Clara, California, is a clinical-stage biotechnology company focused on developing innovative therapies for cancer treatment. The company's approach involves targeted nutrient deprivation, which identifies and exploits metabolic vulnerabilities specific to cancer cells. By depleting nutrients critical to cancer growth without using traditional drugs, Filtricine aims to provide effective treatments that minimize harm to healthy cells.

Founded in 2014, QuantumCyte develops an automated tissue dissection system that uses digital maps to isolate regions of interest containing informative biomarkers. This platform aims to improve cancer outcomes by enabling precise cellular data analysis for predicting drug efficacy.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.