National Institutes of Health

CareTaker Medical develops wireless patient monitoring devices. Its flagship product, CareTaker, is a wearable system that measures continuous beat-by-beat blood pressure, heart rate, respiration rate, and other hemodynamic parameters using only a finger cuff. The device securely transmits data over cellular networks or Bluetooth to enable remote patient monitoring within hospitals and during transport.

CardieX is a global health technology company focused on cardiovascular health management, including hypertension and vascular disorders. It designs, manufactures, and markets medical devices and digital health tools that measure cardiovascular risk, monitor arterial stiffness and central blood pressure, and support patient management across hospitals, clinics, research institutions, and pharmaceutical companies in the Americas, Europe, and the Asia-Pacific region. The company offers TeleHealth services with digital, e-commerce, and mobile tools enabling online connections with health coaches. Its products include devices based on patented arterial stiffness and central blood pressure technologies, and wearables with health analytics. CardieX collaborates with external partners to develop wearable sensors and hypertension programs. The company traces its origins to AtCor Medical and rebranded to CardieX in 2018. CardieX was founded in 1994 and is headquartered in Sydney, Australia.

Amissa develops mobile and wearable application solutions aimed at alleviating the challenges of Alzheimer's care. The company’s technology empowers caregivers by allowing them to geo-fence and locate loved ones who may wander, remotely monitor their activity and health, and predict behaviors associated with Alzheimer's. In addition to these features, Amissa offers wearable biosensors integrated with a cloud-based data platform that collects biometric data on activity levels, sleep patterns, and physiological changes. This comprehensive approach not only aids caregivers in monitoring patients but also provides valuable insights for researchers seeking to understand disease progression, ultimately enhancing the quality of life for individuals with dementia and related disorders.

Lasarrus is a medical device company founded in 2013 and headquartered in Baltimore, Maryland. The company specializes in developing wearable devices aimed at enhancing the physical therapy experience for patients, particularly those with chronic obstructive pulmonary disease. Lasarrus's innovative device facilitates remote monitoring and telemedicine by capturing physiological and range-of-motion data from various points on the body. This technology provides patients with an affordable, comfortable, and non-invasive means to track their health routines and accelerate their recovery process.

Behaivior LLC is a digital health company based in Pittsburgh, Pennsylvania, focused on predicting and preventing addiction relapses through innovative technology. Founded in 2017, Behaivior integrates wearable devices with machine learning algorithms to analyze real-time data from various physiological metrics, such as heart rate and skin temperature. The company’s platform, known as Recovery, employs this data to deliver timely interventions tailored to the needs of individuals in recovery. By utilizing a SaaS business model, Behaivior aims to democratize mental health recovery and support, assisting users in maintaining their wellness while enabling care providers to enhance their service delivery. Through its proactive approach, Behaivior seeks to improve mental health outcomes and reduce crisis events associated with addiction.

Rhaeos is a pioneering company that has developed the world's first wearable shunt monitor, designed to enhance the quality of care for patients with hydrocephalus. Utilizing a novel thermal biosensor, Rhaeos addresses a critical clinical need by offering noninvasive, wireless patches that detect fluid flow in various bodily systems, including blood, lymph, and cerebrospinal fluid. This innovative technology enables timely treatment for chronic medical conditions, particularly in the field of neurosurgery. Founded through collaborative efforts at Northwestern University, Rhaeos exemplifies a multidisciplinary approach, integrating expertise from engineering, medicine, and management to advance patient care.

NeuroGeneces develops an artificial intelligence driven brain health assessment platform to detect early signs of neurodegeneration before cognitive symptoms appear. Its Brain Age test analyzes patient EEG data collected via a sleep headband and ML software, benchmarking against a proprietary normative database to provide objective measures of brain function. The platform enables healthcare practitioners to identify at-risk individuals and guide preventive interventions through early behavioral strategies, offering more comprehensive insights than traditional biomarkers.

Sensor-Kinesis Corporation develops innovative medical devices focused on pathogen and virus detection. Founded in 2013 and based in Los Angeles, the company is advancing proprietary biosensor technology that integrates flexible micro biosensor chips with computer systems. These chips are designed to detect specific biomolecules and can be printed on various surfaces, enabling widespread application across multiple industries, including healthcare, food safety, and pharmaceuticals. By linking these sensors to smart devices, users can transmit and analyze biological signals in real time, facilitating improved health monitoring. Sensor-Kinesis aims to empower healthcare professionals and individuals with affordable, portable devices that provide enhanced detection capabilities for diseases and health-related risks, promoting better health outcomes and safety.

CardieX is a global health technology company focused on cardiovascular health management, including hypertension and vascular disorders. It designs, manufactures, and markets medical devices and digital health tools that measure cardiovascular risk, monitor arterial stiffness and central blood pressure, and support patient management across hospitals, clinics, research institutions, and pharmaceutical companies in the Americas, Europe, and the Asia-Pacific region. The company offers TeleHealth services with digital, e-commerce, and mobile tools enabling online connections with health coaches. Its products include devices based on patented arterial stiffness and central blood pressure technologies, and wearables with health analytics. CardieX collaborates with external partners to develop wearable sensors and hypertension programs. The company traces its origins to AtCor Medical and rebranded to CardieX in 2018. CardieX was founded in 1994 and is headquartered in Sydney, Australia.

Behaivior LLC is a digital health company based in Pittsburgh, Pennsylvania, focused on predicting and preventing addiction relapses through innovative technology. Founded in 2017, Behaivior integrates wearable devices with machine learning algorithms to analyze real-time data from various physiological metrics, such as heart rate and skin temperature. The company’s platform, known as Recovery, employs this data to deliver timely interventions tailored to the needs of individuals in recovery. By utilizing a SaaS business model, Behaivior aims to democratize mental health recovery and support, assisting users in maintaining their wellness while enabling care providers to enhance their service delivery. Through its proactive approach, Behaivior seeks to improve mental health outcomes and reduce crisis events associated with addiction.

Epicore Biosystems, Inc. is a Cambridge, Massachusetts-based company that develops and commercializes a proprietary wearable microfluidic sensing platform designed for athletes. Founded in 2017, the company focuses on analyzing small droplets of sweat directly from the skin to measure a range of health and performance metrics. Its technology allows for non-invasive monitoring of sweat biomarkers, skin health, and physiological states in real-time, facilitating personalized management of hydration, nutrition, and overall health. Epicore's innovative platform is grounded in extensive research in microfluidics and soft materials, aiming to enhance athletic performance and health management through accessible and cost-effective solutions.

Xtrava Health, established in 2014 and headquartered in Santa Clara, California, specializes in developing contactless bio-sensing technology for health and wellness applications. The company's flagship product, Butterfly, is a wearable child wellness monitor that automatically tracks vital signs, sleep patterns, feeding, diaper changes, and activities, providing parents with comprehensive insights. Xtrava Health also develops and commercializes simple, accurate, and affordable diagnostic products for both professional and at-home use, focusing on respiratory health, employee wellness, and baby monitoring.

Biomotum is a company that specializes in the design and development of wearable robotic exoskeletons aimed at enhancing mobility for individuals facing challenges in walking due to health issues. The company's innovative systems integrate advanced assistive technology with user-friendly therapeutic features, providing real-time training insights and compatibility with tele-rehabilitation. Biomotum's products are particularly beneficial for those affected by neurologic disorders such as stroke and cerebral palsy, offering embedded progress reporting to facilitate effective rehabilitation. Through its focus on empowering mobility, Biomotum addresses the growing need for solutions that support individuals with mobility impairments.

Arcascope develops a health app that uses algorithms tracking circadian rhythms to provide personalized recommendations, helping users reset their internal clocks for improved sleep and overall wellbeing.

Samay specializes in remote respiratory health management. It develops AI-enabled wearable devices that monitor pulmonary volumes, trapped air, heart rates, breathing sounds, and lung temperature. This enables users to analyze their respiratory data and helps prevent respiratory diseases.

AventuSoft specializes in developing innovative biologically inspired solutions aimed at enhancing human efficiency and functionality through advanced engineering. The company focuses on creating cloud-connected wearables designed for cardiopulmonary assessment, particularly in pre-clinical heart failure diagnosis. By utilizing in-depth knowledge of psychoacoustics and novel signal processing techniques, AventuSoft's products aim to simplify medical diagnostics, making cardiac monitoring more accessible and efficient compared to traditional methods. Additionally, the company develops sensors and controls that employ computational auditory scene analysis, which helps in separating and locating sounds in complex auditory environments. This technology not only aids in improving audio-visual aids for hearing-impaired individuals but also democratizes access to high-quality diagnostics, offering significant benefits to patients.

Intake Health develops a non-invasive, continuous health monitoring device that attaches to toilets. It automatically tests urine from flush water to generate lab-quality results for various health and diet indicators. The company aims to predict health conditions and enable personalized prevention by combining AI with thousands of biomarkers collected over time.

Founded in 2013, Recovery Force is a digital health company specializing in wearable medical technology. It manufactures and supplies healthcare apparel, including sleeves and shoes, designed to enhance circulation, reduce post-operative pain, and improve patient mobility.

Founded in 2015, Skelmet specializes in designing and producing custom-fit head-worn products. Utilizing advanced 3D scanning and printing technologies, the company offers bespoke sunglasses tailored to individual facial measurements, ensuring optimal fit and performance for various sports activities.

Arcascope develops a health app that uses algorithms tracking circadian rhythms to provide personalized recommendations, helping users reset their internal clocks for improved sleep and overall wellbeing.

Behaivior LLC is a digital health company based in Pittsburgh, Pennsylvania, focused on predicting and preventing addiction relapses through innovative technology. Founded in 2017, Behaivior integrates wearable devices with machine learning algorithms to analyze real-time data from various physiological metrics, such as heart rate and skin temperature. The company’s platform, known as Recovery, employs this data to deliver timely interventions tailored to the needs of individuals in recovery. By utilizing a SaaS business model, Behaivior aims to democratize mental health recovery and support, assisting users in maintaining their wellness while enabling care providers to enhance their service delivery. Through its proactive approach, Behaivior seeks to improve mental health outcomes and reduce crisis events associated with addiction.

Modulim is a company developing light-based imaging devices based on spatial frequency domain imaging (SFDI) for tissue and vascular assessment. The Clarifi Imaging System helps identify patients at risk of complications such as diabetic foot ulcers and potential limb loss due to compromised circulation, enabling clinicians to intervene earlier and protect limbs. The company's devices support skin assessment and treatment monitoring, providing tools to prevent, diagnose, and monitor medical skin conditions.

Wearable sensors are transforming healthcare by empowering health researchers, care providers, and patients with new insights.Together with their clinical research and enterprise partners, They develop innovative, market driven, wearable sensor solutions that address some of healthcare’s biggest challenges.

Mobile Sense Technologies, Inc. specializes in the development of innovative wearable wireless sensor bands for cardiac monitoring. Its primary product, SensBand, is designed to be worn on the arm or wrist and enables automatic monitoring, detection, and reporting of dangerous heart arrhythmias directly to patients and their healthcare providers. Founded in 2016 and based in Farmington, Connecticut, the company has invested significant resources into creating a platform for differentiated wearables. The technology includes non-adhesive, wireless, and waterproof sensors that provide continuous ECG and PPG recordings, allowing for 24/7 monitoring and classification of heart conditions. Mobile Sense Technologies aims to transform the traditional diagnostic market by utilizing advanced wearables that facilitate long-term management of cardiac health.

ReThink Medical, Inc. is a medical device and digital health company based in San Francisco, California, founded in 2010. The company specializes in the development of wrist-worn monitoring devices designed to predict and prevent hospitalizations due to heart failure. Their flagship product, CorBand™, utilizes advanced algorithms and artificial intelligence to continuously monitor physiological indicators such as heart rate and fluid status. This technology enables early detection of worsening heart conditions, potentially weeks in advance of noticeable symptoms. By focusing on compliance and ease of use, ReThink Medical aims to provide proactive management of heart failure patients, improving their quality of life while reducing healthcare costs associated with emergency interventions. In 2020, ReThink Medical became a subsidiary of Terumo Corporation.

Epitel is a digital health company developing a wearable, wireless EEG monitoring platform that enables accessible, reliable seizure detection. The system combines a cloud-based wearable sensor network with artificial intelligence to identify electrographic seizures, providing brain health insights for physicians, caregivers, and patients with neurological disorders to improve quality of life and care.

SpeechVive Inc. is a medical device company developing a wearable speech device to assist people with Parkinson's disease by improving speech and communication. Founded in 2011 and based in Lafayette, Indiana, the company aims to enhance speech volume and clarity for daily life. The device is designed to suppress ambient background sound, which helps users hear themselves more clearly and speak more effectively, addressing communication challenges associated with Parkinson's disease.

Shade is a New York-based company that specializes in the design and development of wearable ultraviolet measuring technology. Its primary focus is on creating ultra-accurate and ultra-sensitive UV sensors, specifically aimed at assisting patients with lupus, skin cancer, and diabetes. The company's innovative devices provide real-time and precise measurements of UV exposure, based on clinical evidence. By determining daily UV exposure thresholds, Shade's sensors enable patients to receive timely notifications, helping them make informed decisions about sun exposure. This technology is particularly beneficial in the field of dermatology for managing photosensitive diseases and enhancing patient care.

Chrono Therapeutics Inc. is a pharmaceutical company based in Hayward, California, focused on revolutionizing drug delivery and addiction management. Founded in 2003, the company specializes in the development of SmartStop, a digital nicotine replacement therapy that employs a wearable device to deliver programmable, transdermal drug therapy. This innovative system is designed to tailor the timing and dosage of nicotine while providing real-time behavioral support to help users manage addiction and smoking cessation effectively. Chrono Therapeutics aims to address the challenges associated with smoking addiction through its advanced technology, which seeks to achieve optimal clinical outcomes and improve the overall quality of life for users. The company's leadership team brings extensive experience in product development, research and development, and navigating regulatory pathways, positioning Chrono Therapeutics as a key player in the smoking cessation market.

UroDev Medical is a company focused on developing innovative medical devices aimed at enhancing the quality of life for individuals with spinal cord injuries and diseases. Its flagship product, The Connected Catheter, introduces a semi-permanent, minimally-invasive smart catheter system. This device measures bladder pressure and wirelessly transmits data to a smartphone, streamlining bladder management for users. By eliminating the need for intermittent catheters and drainage bags, UroDev Medical enables both users and clinicians to effectively control the valve that facilitates urine drainage from the bladder.

Epitel is a digital health company developing a wearable, wireless EEG monitoring platform that enables accessible, reliable seizure detection. The system combines a cloud-based wearable sensor network with artificial intelligence to identify electrographic seizures, providing brain health insights for physicians, caregivers, and patients with neurological disorders to improve quality of life and care.

ReThink Medical, Inc. is a medical device and digital health company based in San Francisco, California, founded in 2010. The company specializes in the development of wrist-worn monitoring devices designed to predict and prevent hospitalizations due to heart failure. Their flagship product, CorBand™, utilizes advanced algorithms and artificial intelligence to continuously monitor physiological indicators such as heart rate and fluid status. This technology enables early detection of worsening heart conditions, potentially weeks in advance of noticeable symptoms. By focusing on compliance and ease of use, ReThink Medical aims to provide proactive management of heart failure patients, improving their quality of life while reducing healthcare costs associated with emergency interventions. In 2020, ReThink Medical became a subsidiary of Terumo Corporation.

Xhale is a company based in Gainesville, Florida, founded in 2005, that specializes in developing advanced patient monitoring technologies. The company is known for its innovative SMART medication adherence monitoring technology and a propofol monitor, both aimed at enhancing patient care in clinical settings. Xhale's devices are designed to improve conventional pulse oximetry by enabling the monitoring of critical patient parameters through a simple, effective single-point-of-contact sensor. In 2010, Xhale successfully commercialized its HyGreen hand hygiene monitoring system, which later became a separate entity with its own management team. The company's focus on expanding the capabilities of patient monitoring is intended to improve health outcomes in hospitals and other clinical environments.