National Science Foundation

Dynocardia, Inc. is a biomedical device company focused on developing innovative healthcare solutions. Founded in 2018 and based in Cambridge, Massachusetts, Dynocardia specializes in manufacturing wireless blood pressure measurement equipment. Its flagship product, the ViTrack, is a wrist-wearable device that provides users with accurate, real-time measurements of blood pressure, heart rate, heart rhythm, and respiration rate. The technology employs a non-invasive optomechanical sensor to deliver continuous and precise blood pressure readings, comparable to traditional intra-arterial methods. By addressing critical unmet needs in health monitoring, Dynocardia aims to enhance patient care and facilitate easier access to vital health metrics.

Worcester Polytechnic Institute (WPI), located in Worcester, Massachusetts, is a prestigious technological university founded in 1865. Renowned for its commitment to project-based learning, WPI emphasizes practical application of theoretical knowledge to address real-world challenges. The university boasts a distinguished faculty and state-of-the-art research facilities, fostering an environment rich in innovation and collaboration. WPI attracts ambitious students eager to engage in hands-on experiences that prepare them to make meaningful contributions to society. With a strong focus on developing skills that are crucial in today’s dynamic landscape, WPI positions itself as a leader in education and research, dedicated to empowering its students and faculty to achieve excellence.

Theromics Inc. is a biotechnology company that specializes in developing innovative cell therapies aimed at improving the effectiveness of thermal ablation techniques for cancer treatment. Founded in 2016 and based in West Bridgewater, Massachusetts, the company has created HeatSYNC Gel, a thermal accelerant designed to enhance the transmission of thermal energy during microwave and radiofrequency ablations of soft tissue tumors. This novel biopolymer gel, derived from a naturally occurring protein, is administered through various medical devices such as syringes, laparoscopes, or bronchoscopes. HeatSYNC Gel increases local tissue electrical conductivity, optimizes the shape of the ablation zone, and protects surrounding critical tissues, thereby enabling physicians to achieve more accurate and effective ablation outcomes. Through its advanced thermal management solutions, Theromics addresses significant medical needs in the field of cancer treatment.

Thiozen is a company based in Belmont, Massachusetts, founded in 2020, that specializes in innovative hydrogen gas production technology aimed at reducing greenhouse gas emissions. The company has developed a unique chemical process that converts hydrogen sulfide into hydrogen gas. This approach allows clients to sidestep the carbon emissions typically associated with hydrogen production from natural gas, as well as the high costs linked to electrolysis methods. By providing a low-cost and low-emission alternative for hydrogen production from sour gases, Thiozen positions itself as a key player in the decarbonization of the energy sector.

The Engine, established by the Massachusetts Institute of Technology (MIT) in 2016, is a venture firm focused on supporting early-stage companies that tackle significant global challenges through innovative science and engineering. The Engine prioritizes transformative ideas over immediate profitability, offering a streamlined system that accelerates the progression from concept to market. It provides a physical workspace for startups, along with essential resources such as business planning, legal assistance, and administrative support. The Engine also connects entrepreneurs with "patient capital" from like-minded investors, allowing startups to maintain greater control over their ventures. With plans to support up to 60 startups simultaneously over a 12-month period, The Engine aims to facilitate rapid development and validation of groundbreaking concepts. Additionally, it offers access to specialized equipment and lab space through the Engine Room, fostering a collaborative environment that nurtures innovation within the MIT community and beyond.

Rapid7, established in 2000, is a cybersecurity company that offers a range of solutions to help organizations proactively manage their security. Initially focusing on vulnerability management, the company has since expanded its portfolio to include detection and response, security information and event management, cloud security, threat intelligence, application security, and security orchestration, automation, and response. Rapid7 empowers businesses with visibility and insights to make informed security decisions, create action plans, and monitor progress. The company, based in Boston, is committed to helping organizations enhance their security posture and is actively involved in the cybersecurity community.

Remedium Bio is a Boston-based gene therapy company dedicated to developing curative treatments for a variety of debilitating conditions. The company employs a unique approach that combines established technologies in innovative ways to address well-defined disease mechanisms. By modularly applying these proven technologies, Remedium Bio focuses on creating localized and targeted therapies centered on clinically validated molecules and pathways. Its pipeline includes leading gene therapy candidates in multiple fields, such as rheumatology, endocrinology, and neurology, aimed at providing effective treatments for a range of immune, age-related, and metabolic disorders.

Quantivly, Inc., established in 2019 and headquartered in Somerville, Massachusetts, specializes in developing artificial intelligence-based solutions tailored for the field of radiology. The company focuses on enhancing data liquidity and providing analytical tools that enable radiology providers to make informed decisions, thereby increasing access to medical imaging services. Quantivly's platform is designed to manage and analyze MRI imaging workflows by cleaning and harmonizing scanner data, resulting in a vendor-neutral and comprehensive source of operational knowledge. This innovative approach supports radiology departments and imaging centers in utilizing data analytics to improve decision-making, facilitate new research initiatives, and enhance the overall patient experience in healthcare.

The University of Massachusetts Amherst is a public research and land-grant university that offers undergraduate, master's, and doctoral programs. It serves as the flagship campus of the University of Massachusetts system. The university has multiple academic departments and research facilities that support a range of disciplines.

QSimulate is a Boston-based company that specializes in developing cloud-based quantitative simulation tools focused on quantum molecular simulations. By leveraging the principles of quantum mechanics, QSimulate aims to address significant industrial-scale challenges primarily within the chemical and pharmaceutical sectors. Its innovative platform automates various workflows, allowing computational scientists to shift their focus from repetitive tasks to more strategic activities, ultimately enhancing productivity. This approach enables clients to accelerate their research and development processes, positioning QSimulate as a key player in advancing scientific inquiry and innovation in these industries.

Singularity Energy, Inc. is a technology company focused on developing a platform for real-time carbon tracking and energy optimization. Founded in 2018 and headquartered in Cambridge, Massachusetts, the company utilizes artificial intelligence to integrate real-time carbon dioxide signals from the energy grid into its solutions. This enables corporate clients, including climate regulators and sustainability directors, to visualize and co-optimize their energy usage and carbon emissions effectively. Singularity Energy's innovative approach combines data analytics with carbon forecasting and optimization algorithms, allowing organizations to minimize their emissions while maximizing economic benefits. The company's mission is to support entities in achieving their sustainability goals with transparency and confidence.

Belmont Scientific is a chemical and battery safety technology company that specializes in process safety and risk management. The company was founded in 2011 and is based in Lowell, Massachusetts.

RaySecur Inc. is a company based in Cambridge, Massachusetts, focused on developing advanced 3D package scanning and imaging devices for detecting concealed threats in mail and parcels. Founded in 2018, RaySecur's MailSecur systems utilize millimeter-wave technology to provide real-time, three-dimensional imaging, which allows for the detection of powders, solids, liquids, and hazardous materials such as chemical, biological, radiological, and explosive composites. Unlike traditional X-ray systems, RaySecur's solutions are user-friendly, portable, and do not require extensive training for effective operation, making them suitable for various environments, including small mailrooms. The company’s technology is employed by Fortune 500 companies and government organizations worldwide to enhance security and protect personnel and assets from potential threats.

Lura Health is a pioneering company that has developed a non-invasive continuous health monitoring platform utilizing saliva as a diagnostic fluid. Founded in 2017 and headquartered in Cambridge, Massachusetts, the company focuses on chronic disease management, targeting conditions such as heart disease, chronic kidney disease, diabetes, and tooth decay. Lura Health's innovative sensors are designed to be integrated into patient-friendly orthodontic devices, including removable retainers and fixed brackets. These sensors continuously monitor oral acidity and other analytes in saliva, automatically transmitting valuable health data to a mobile application. This approach empowers users to track key diagnostic metrics within their oral environment, facilitating improved personal health management and potentially enhancing clinical outcomes.

Dynocardia, Inc. is a biomedical device company focused on developing innovative healthcare solutions. Founded in 2018 and based in Cambridge, Massachusetts, Dynocardia specializes in manufacturing wireless blood pressure measurement equipment. Its flagship product, the ViTrack, is a wrist-wearable device that provides users with accurate, real-time measurements of blood pressure, heart rate, heart rhythm, and respiration rate. The technology employs a non-invasive optomechanical sensor to deliver continuous and precise blood pressure readings, comparable to traditional intra-arterial methods. By addressing critical unmet needs in health monitoring, Dynocardia aims to enhance patient care and facilitate easier access to vital health metrics.

AM Batteries is a manufacturer of lithium-ion batteries based in Chelmsford, Massachusetts, established in 2016. The company specializes in an innovative solvent-free electrode manufacturing technology that addresses the issues associated with traditional solvent-based methods. By employing dry electrode manufacturing, AM Batteries enhances the efficiency of battery production by eliminating the need for solvent recovery and drying processes. This advancement not only reduces energy consumption during manufacturing but also has the potential to yield batteries that offer faster charging, increased energy output, and lower overall costs.

Boston Geospatial is a developer of a geospatial data platform that specializes in providing ready-to-use insights for operators and risk managers within critical infrastructure sectors. The company's platform facilitates access to satellite data from various providers, offering a searchable and comparable database that can be analyzed in multiple ways. This functionality empowers stakeholders to obtain valuable geospatial insights, aiding in informed decision-making and risk management.

Alloy Enterprises Inc., incorporated in 2020 and located in Somerville, Massachusetts, specializes in developing advanced 3D printing technologies aimed at improving conventional manufacturing processes. The company focuses on addressing inefficiencies in the production of aluminum parts through its innovative aluminum additive technology. This technology enables the creation of dense and cost-effective components without the need for expensive and hazardous powders. By offering solutions that overcome traditional manufacturing limitations, Alloy Enterprises seeks to foster innovation and support advancements in lightweight materials and emissions reduction.

Thiozen is a company based in Belmont, Massachusetts, founded in 2020, that specializes in innovative hydrogen gas production technology aimed at reducing greenhouse gas emissions. The company has developed a unique chemical process that converts hydrogen sulfide into hydrogen gas. This approach allows clients to sidestep the carbon emissions typically associated with hydrogen production from natural gas, as well as the high costs linked to electrolysis methods. By providing a low-cost and low-emission alternative for hydrogen production from sour gases, Thiozen positions itself as a key player in the decarbonization of the energy sector.

Chibitronics is a company that specializes in the creation of circuit stickers, which integrate technology and art through an innovative approach to electronics. Founded from Jie Qi's PhD research at the MIT Media Lab, Chibitronics produces peel-and-stick electronics that allow users to engage in circuit building and programming in a creative manner. The company offers toolkits that combine conductive circuit stickers, coin cell batteries, and adhesive copper tape, enabling artists, crafters, tinkerers, and students to design their own expressive electronics. Through its products, Chibitronics aims to democratize technology creation, making it accessible and enjoyable for individuals interested in exploring the intersection of art and circuitry.

Biko Biolabs is a research company established in 2020 and located in Somerville, Massachusetts. The company focuses on bridging the gap between plastic waste and regenerative agriculture, aiming to promote sustainability and self-sufficiency in traditionally marginalized communities. Biko Biolabs provides a platform for innovators to create new economic opportunities and fosters the development of the next generation of local scientists and engineers. By emphasizing research that is contextually relevant to specific communities, Biko Biolabs enables individuals to customize scientific practices and technologies to address the fundamental needs of their communities effectively.

Skyhaven Systems is a specialty research and development firm based in Steamboat Springs, Colorado, with primary research and development facilities located in Westford, Massachusetts. Founded in 2017 through the merger of Reactive Innovations, LLC, the company focuses on addressing critical needs in the Defense, Energy, Aerospace, and Environmental sectors for various U.S. government agencies, including the Department of Defense and NASA. Skyhaven applies advanced electrochemical engineering and reaction-based chemical processes to tackle complex technical challenges, conducting innovative work in areas such as reactor design, separation systems, and materials development. The firm operates a 4,200 square foot facility for research, development, and light manufacturing, and it pursues government-funded contracts to explore high-risk development areas. By retaining ownership of the technology rights generated from these projects, Skyhaven can commercialize its innovations for non-government applications while providing the government with a royalty-free license to use the technologies developed. This approach positions Skyhaven as a key player in creating sustainable solutions that enhance performance and reduce costs across various industries.

MedChem Partners is a medicinal chemistry CRO that specializes in developing small molecule therapeutics. The company was founded in 2006 and is headquartered in Lexington, Massachusetts.

Theromics Inc. is a biotechnology company that specializes in developing innovative cell therapies aimed at improving the effectiveness of thermal ablation techniques for cancer treatment. Founded in 2016 and based in West Bridgewater, Massachusetts, the company has created HeatSYNC Gel, a thermal accelerant designed to enhance the transmission of thermal energy during microwave and radiofrequency ablations of soft tissue tumors. This novel biopolymer gel, derived from a naturally occurring protein, is administered through various medical devices such as syringes, laparoscopes, or bronchoscopes. HeatSYNC Gel increases local tissue electrical conductivity, optimizes the shape of the ablation zone, and protects surrounding critical tissues, thereby enabling physicians to achieve more accurate and effective ablation outcomes. Through its advanced thermal management solutions, Theromics addresses significant medical needs in the field of cancer treatment.

Stellate DNA, founded in 2020 and based in Cambridge, Massachusetts, specializes in proprietary DNA donor technology that enables the synthesis and production of single-strand DNA donors. The company's innovative platform employs clonal synthesis methods instead of traditional chemical synthesis, allowing for the customizable production of gene knock-in payloads. This approach ensures that Stellate DNA can achieve microgram to milligram scale production while maintaining well-controlled costs. Additionally, the technology supports medical professionals by ensuring minimal mutation rates and sequence uniformity, which are critical for various applications in genetic research and therapy.

Simpact is a Boston-based company that specializes in developing analytics and forecasting software designed to aid businesses in making informed, data-driven decisions. The software utilizes computer simulations to model target social systems, allowing clients to evaluate risks related to influencers, trends, and interventions. By doing so, Simpact enables organizations to effectively forecast the outcomes of various allocations of their limited resources, ultimately enhancing their strategic planning and decision-making processes.

Xheme is a technology company founded in 2019 and based in Newton, Massachusetts, that specializes in developing advanced blood bag technology aimed at extending the shelf life of blood and platelets. The company also focuses on creating specialty chemicals designed to enhance product quality, sustainability, and safety across various industrial sectors. Xheme's innovative products are programmable, allowing them to provide multiple protective functions such as resistance to oxidation, ultraviolet light, corrosion, and microbial threats. This versatility enables industries to preserve the aesthetic and functional quality of their products over extended periods.

Heila Technologies, Inc. is a Massachusetts-based company that specializes in the development of a platform designed to integrate and optimize distributed energy resources (DERs) such as solar arrays and batteries. The Heila Platform employs a decentralized optimization system that simplifies the management of these resources, enabling the creation of self-managing microgrids. By transforming individual nodes within the energy system into intelligent agents, the platform facilitates autonomous coordination and optimization of power assets. This approach helps to reduce complexity and costs while enhancing resilience and efficiency in energy operations. Heila Technologies serves a diverse clientele, including partners, utility representatives, developers, energy users, and public officials. Originally founded as Heila Technologies LLC, the company was incorporated in 2015 and has its roots in MIT.

Irradiant Technologies, founded in 2020 and based in Cambridge, Massachusetts, specializes in advanced nanofabrication solutions. The company has developed a unique implosion fabrication lithography platform that facilitates the ultrafast three-dimensional assembly of various materials, including conductors, semiconductors, dielectrics, proteins, and DNA. This innovative technology enables the creation of complex geometries with nanoscale precision and gradient control. By providing these capabilities, Irradiant Technologies aims to empower the development of novel photonic and optical components, offering light-based alternatives for applications in telecommunications, computation, and sensing.

FluidForm Bio is a biotechnology company focused on creating living human tissue to improve disease treatment. Utilizing its patented FRESH technology, the company employs 3D printing to construct tissue using cells, proteins, and no other materials. This innovative platform has been validated through partnerships with leading life science companies, enabling the production of high-quality tissue for various applications. FluidForm Bio's advanced techniques integrate breakthroughs in 3D printing, computational and synthetic biology, artificial intelligence, and materials science to deliver human tissue that closely resembles natural tissue. Established in 2018 and headquartered in Waltham, Massachusetts, FluidForm Bio aims to provide transformative therapies that offer better treatment options for patients in need.

Aliro Technologies, Inc. specializes in developing a cloud-based software-as-a-service platform designed for coding within quantum environments. Founded in 2019 and headquartered in Boston, Massachusetts, the company provides a hardware-independent toolkit aimed at developers of quantum algorithms and applications for quantum computers. Known as AliroNet™, this platform facilitates the emulation, piloting, and deployment of entanglement-based quantum networks, which can support a wide range of applications from secure communications to clustered quantum computing and distributed quantum sensing. With a foundation rooted in research from Harvard University, Aliro Technologies comprises experts in both quantum and classical networking, positioning itself as a leader in quantum network development. Its user base spans utility companies, telecommunications providers, public sector organizations, enterprises, and researchers engaged in building the first entanglement-based quantum networks. The company also collaborates with industry and academic partners through various consortiums and is actively involved in quantum networking standards groups.

Enable Therapeutics is a biotechnology company developing a patented drug delivery platform. The company was founded in 2020 and is headquartered in Hopedale, Massachusetts.

SiTration, founded in Cambridge, Massachusetts in 2020 by Brendan Smith, specializes in developing ultra-durable filtration membrane technology. This technology is designed to efficiently separate substances in harsh and challenging industrial environments while reducing energy consumption compared to conventional methods. The company's membranes combine the advantages of various state-of-the-art commercial membranes, offering users resource-efficient operations even in unpleasant industrial settings.

SilarTek is a technology company established in 2020 and located in Leominster, Massachusetts. The company specializes in developing innovative solar silicon technology aimed at making solar panels more affordable and accessible to a broader audience. SilarTek's unique approach involves utilizing molten salt electrolysis combined with an advanced molten salt composition, which enables the production of low-cost solar-grade silicon. This technology is designed to benefit both consumers and businesses by providing an efficient solution for solar panel manufacturing.

Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, dedicated to developing innovative treatments for multi-drug resistant (MDR) bacterial infections and rare diseases. Founded in 2013, the company is advancing several product candidates, including tebipenem pivoxil hydrobromide, an oral carbapenem-class antibiotic aimed at treating MDR gram-negative infections in adults. Additionally, Spero is developing SPR206, an intravenous agent for MDR gram-negative infections in hospital settings, and SPR720, an oral antibiotic targeting pulmonary non-tuberculous mycobacterial disease. The company collaborates with various partners, including Meiji Seika Pharma to support tebipenem HBr's development and the Bill & Melinda Gates Medical Research Institute for SPR720. Spero Therapeutics employs a focused approach to drug development, emphasizing novel mechanisms to address the urgent need for effective therapeutics against serious bacterial infections.

Quantivly, Inc., established in 2019 and headquartered in Somerville, Massachusetts, specializes in developing artificial intelligence-based solutions tailored for the field of radiology. The company focuses on enhancing data liquidity and providing analytical tools that enable radiology providers to make informed decisions, thereby increasing access to medical imaging services. Quantivly's platform is designed to manage and analyze MRI imaging workflows by cleaning and harmonizing scanner data, resulting in a vendor-neutral and comprehensive source of operational knowledge. This innovative approach supports radiology departments and imaging centers in utilizing data analytics to improve decision-making, facilitate new research initiatives, and enhance the overall patient experience in healthcare.

GreenSight Agronomics, Inc., established in 2015 and headquartered in Brookline, Massachusetts, specializes in manufacturing drones tailored for turfgrass and agricultural applications. The company operates a cloud-based platform that integrates automated drone systems, advanced sensors, and data analytics to provide actionable insights for land managers. GreenSight's services include plant health monitoring, irrigation management, crop protection, and labor management, primarily serving the golf course industry with potential savings of over $1 billion annually through water reduction alone. The company aims to expand its services to other agricultural sectors, such as farms and energy infrastructure, using its advanced sensor technology and autonomous drone capabilities.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

Ernest Pharmaceuticals is a biotechnology company founded in 2016 and based in Hadley, Massachusetts. The company specializes in developing innovative bacterial therapeutics aimed at treating cancer. Its unique approach involves the use of programmed bacteria that are engineered with synthetic techniques to deliver intracellular macromolecules. These motile bacteria actively penetrate tumor tissue, which enhances their ability to target metastatic disease and inoperable tumors. By focusing on this novel method of cancer treatment, Ernest Pharmaceuticals seeks to advance therapeutic options for patients facing difficult-to-treat malignancies.

Thinking Robots is a Boston-based company founded in 2010 that specializes in developing software solutions for robotic tasks applicable across various robotic platforms. The company focuses on creating custom software that enhances robotic capabilities, integrating natural language dialogue, sensors, actuators, and high-level planning. This advanced architecture enables robots to interact with humans, transforming them into interactive and teachable entities that can be directly instructed by users. Through its innovative approach, Thinking Robots aims to facilitate the development of more responsive and user-friendly robotic systems.

Millimeter Wave Systems, founded in 2016 and headquartered in Amherst, Massachusetts, specializes in millimeter wave and microwave hardware solutions. The company develops a range of products, including subsystems, modules, components, and antennas, as well as advanced technologies such as cryogenic quantum-limited parametric amplifiers and latching junction ferrite circulators. These innovations are utilized in various applications, including medical scanners, sensors, automobile radars, and high data-rate communications. Millimeter Wave Systems aims to provide consistent quality in production while offering customizable solutions tailored to specific industry needs.

Worcester Polytechnic Institute (WPI), located in Worcester, Massachusetts, is a prestigious technological university founded in 1865. Renowned for its commitment to project-based learning, WPI emphasizes practical application of theoretical knowledge to address real-world challenges. The university boasts a distinguished faculty and state-of-the-art research facilities, fostering an environment rich in innovation and collaboration. WPI attracts ambitious students eager to engage in hands-on experiences that prepare them to make meaningful contributions to society. With a strong focus on developing skills that are crucial in today’s dynamic landscape, WPI positions itself as a leader in education and research, dedicated to empowering its students and faculty to achieve excellence.

Leading Edge Equipment Technologies, Inc. is a manufacturer and supplier of advanced equipment for solar panel production, specializing in single-crystal silicon wafers. Established in 2008 and based in Wilmington, Massachusetts, the company has developed a kerfless method that significantly reduces the costs associated with producing silicon wafers while increasing the efficiency of solar panels. This innovative process eliminates the need for wire-sawing large silicon ingots and utilizes less energy-intensive furnaces, resulting in higher efficiency solar cells and reduced carbon emissions. By offering a solution that integrates seamlessly into existing manufacturing processes, Leading Edge Equipment Technologies enables solar cell and panel manufacturers to enhance their products' power output without requiring substantial changes to their operations. The company, which rebranded from Leading Edge Crystal Technologies in May 2020, continues to advance technologies that support the growth of sustainable energy solutions.

Armada Marine Robotics, headquartered in Falmouth, Massachusetts, specializes in developing asymmetric propulsion technology. This innovation enhances marine maneuverability by providing both thrust and steering from a single motor, enabling customers to create more efficient and agile underwater vehicles.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Travera, LLC is a biotechnology company based in Cambridge, Massachusetts, founded in 2017. It specializes in cancer therapy guidance through its innovative measurement technology, utilizing the Suspended Microchannel Resonator (SMR). This advanced device functions as an extremely sensitive scale that can detect minute changes in the weight of individual cancer cells, specifically measuring the Mass Accumulation Rate (MAR) biomarker. By identifying rapid weight changes in response to cancer drugs, Travera enables oncologists to make informed decisions about which therapies to prescribe, based on the actual responses of patients' tumor cells. The technology is designed to differentiate between natural cell death and drug-induced cell death, providing timely and accurate insights that are critical for effective cancer treatment.

Lura Health is a pioneering company that has developed a non-invasive continuous health monitoring platform utilizing saliva as a diagnostic fluid. Founded in 2017 and headquartered in Cambridge, Massachusetts, the company focuses on chronic disease management, targeting conditions such as heart disease, chronic kidney disease, diabetes, and tooth decay. Lura Health's innovative sensors are designed to be integrated into patient-friendly orthodontic devices, including removable retainers and fixed brackets. These sensors continuously monitor oral acidity and other analytes in saliva, automatically transmitting valuable health data to a mobile application. This approach empowers users to track key diagnostic metrics within their oral environment, facilitating improved personal health management and potentially enhancing clinical outcomes.

Metalmark Innovations, Inc. focuses on developing and delivering advanced 3D nanostructured coatings designed to treat airborne pollutants and toxins, enhancing indoor air quality. The company offers its innovative materials as additive coatings for various applications, including building materials and vehicle interiors, effectively addressing pollutants such as hydrocarbons, carbon monoxide, ozone, PM2.5, volatile organic compounds, odors, and germs. Its air cleaning technology employs catalytic materials that filter air with nanoscale precision, contributing to solutions for air pollution and climate change challenges. Founded in 2017 and headquartered in Boston, Massachusetts, Metalmark Innovations was previously known as Aircrew Technologies, Inc. before rebranding in January 2019.

Infinite Cooling Inc. is a renewable and environmental technology company that specializes in water recovery systems for industrial-scale facilities, particularly power plants. Founded in 2017 and based in Somerville, Massachusetts, the company has developed an innovative technology that utilizes high-voltage electric fields to capture and recycle water that evaporates from cooling towers. This advanced method not only mitigates water scarcity but also significantly reduces water consumption and treatment costs for its clients. By focusing on wastewater management and recycling, Infinite Cooling addresses critical environmental challenges while promoting sustainable practices in industries such as power generation and manufacturing.

Mizar Imaging, founded in 2017 and based in Woods Hole, Massachusetts, specializes in the development of modular light sheet illumination systems aimed at enhancing research and microscopy experiences. The company's innovative systems facilitate high-resolution imaging on most modern inverted microscopes and are compatible with high numerical aperture objectives. This design minimizes photobleaching, allowing researchers to conduct longer imaging sessions of living cells, thereby improving the quality and efficiency of their scientific investigations.

VeraMorph is a pharmaceutical company established in 2017 and based in Mansfield, Massachusetts. The company specializes in developing an innovative oral drug delivery technology that utilizes proprietary oral hydrogel tablets. This technology aims to enhance drug stability, achieve a rapid dissolution rate, and maintain prolonged high saturation levels in oral dosage forms. VeraMorph's approach allows for higher drug loading compared to traditional formulations, enabling pharmaceutical companies to improve product performance while also reducing the cost and time required to bring their products to market. Through its focus on contract manufacturing and formulation services, VeraMorph seeks to advance the efficiency of drug delivery systems in the pharmaceutical industry.

Ichosia Biotechnology, founded in 2019 and headquartered in Worcester, Massachusetts, specializes in the development of derived red blood cells. The company leverages natural genetic processes to genetically engineer human stem cells, creating red blood cells that can be provided to healthcare providers and patients as needed. This innovative approach aims to address the demand for blood in medical settings, ensuring that patients at risk have access to necessary transfusions on demand.

Alloy Enterprises Inc., incorporated in 2020 and located in Somerville, Massachusetts, specializes in developing advanced 3D printing technologies aimed at improving conventional manufacturing processes. The company focuses on addressing inefficiencies in the production of aluminum parts through its innovative aluminum additive technology. This technology enables the creation of dense and cost-effective components without the need for expensive and hazardous powders. By offering solutions that overcome traditional manufacturing limitations, Alloy Enterprises seeks to foster innovation and support advancements in lightweight materials and emissions reduction.

InThePendant is a technological platform founded in 2019 and headquartered in Lexington, Massachusetts. The company focuses on delivering meaningful insights through its innovative technology. By leveraging advanced data analysis and user-friendly interfaces, InThePendant aims to enhance decision-making processes for its clients.

GelSight, Inc. is a technology company based in Waltham, Massachusetts, focused on developing advanced sensor solutions for precise surface measurements. Founded in 2011, GelSight specializes in a unique sensor technology that captures the 3D topography of various rigid materials, providing detailed surface geometry and dimensional measurements with precision down to single-digit microns. Its flagship product, the GelSight benchtop scanner, is designed to meet the diverse needs of industries such as aerospace, electronics, ballistics, and metrology, as well as applications in universities and forensics. The company's innovative approach allows for flexible measurements across a wide range of scales, enabling clients to obtain highly accurate and reliable 3D data that reveals intricate surface details not visible to the naked eye.

Boston Materials, Inc. is a manufacturer of advanced composite materials based in Bedford, Massachusetts, founded in 2016. The company specializes in producing 3D reinforced carbon fiber pre-pregs and offers a patented Z-axis Fiber technology that incorporates vertically aligned carbon fibers. This innovative approach enhances the thermal, electrical, and mechanical properties of materials, making them suitable for various high-growth industries, including semiconductors, aerospace, automotive, and renewable energy. Boston Materials' products are designed to improve performance, efficiency, and reliability while addressing challenges related to durability and weight reduction. The company employs a roll-to-roll manufacturing process with in-line quality control, achieving an annual production capacity of one million square meters.

Bitome is a Boston-based connected medical device company focused on developing innovative monitoring solutions. Founded two years ago, it has created a noninvasive tool for assessing hydration status, which has significant applications in various fields, including dialysis, diabetes management, sports performance, and maternal/fetal health. The company's initial application targets patients with congestive heart failure (CHF), allowing for precise monitoring of volume status—an important yet challenging biometric to measure that is closely linked to patient outcomes. Bitome aims to revolutionize hydration monitoring in a manner comparable to the impact glucose monitoring has had on diabetes care.

Root AI, Inc. is a Woburn, Massachusetts-based company that develops artificial intelligence-powered robots specifically designed for indoor farming. Founded in 2018 by Joshua Lessing and Ryan Knopf, Root AI focuses on creating intelligent robotics that assist growers in building advanced agricultural systems. The company’s flagship product, the Virgo 1, is an autonomous robot capable of harvesting tomatoes without causing bruising and is equipped with advanced vision systems to better assess ripeness than human workers. Root AI aims to enhance efficiency in indoor farming, enabling growers to produce high-quality, chemical-free produce while optimizing operational processes.

Quisigamond Community College, located in Worcester, MA, serves over 13,000 students and offers more than 70 associate degree and certificate programs. In addition to the traditional student academic program, Quisigamond offers online classes specifically geared toward working students or professionals who want to enhance their skills or build new ones. Those classes include Business Administration, Fire Science, Criminal Justice, Computer Science and Hospitality Management. Certificates are available in business administration/insurance or medical office options, Hotel and Restaurant Management, Early Childhood Education, and Law Enforcement. Various healthcare certificates are also offered including Surgery Technology, basic Paramedic and Dental Assisting. Associate Degrees are offered in Deaf Studies, Biomedical Engineering, Electromechanical Technology, Telecommunications Technology and Energy Utility. Quisigamond has developed outstanding relationships with potential employers in the central Massachusetts area including Intel, Verizon, Kennedy Diecasting, UPS and Ken-Weld and sponsors regular collaborations for workforce training. The Children’s School is available for enrolled students and members of the community with children between the ages of 2 to 5 years and also operates as a training center for Early Childhood Education students . The Division of Continuing Education hosts non-credit courses, workshops and seminars that are widely attended by the community and students.

JuliaHub is a platform that facilitates modeling, simulation, and the development of user-built applications. Founded by Viral Shah in Cambridge, Massachusetts, in 2015, JuliaHub provides scientists, engineers, and innovators with comprehensive high-performance computing resources. The platform enables users to discover, search for, build, and share packages while offering effortless parallel computing without the challenges of infrastructure management. JuliaHub specializes in open-source language software designed to simplify deployment, usability, and scalability for various applications, including data science, machine learning, and scientific computing. Its offerings support a range of functions such as research, backtesting, trading, and contract modeling, combining intuitive syntax with robust speed and performance to enhance data processing capabilities.

Singularity Energy, Inc. is a technology company focused on developing a platform for real-time carbon tracking and energy optimization. Founded in 2018 and headquartered in Cambridge, Massachusetts, the company utilizes artificial intelligence to integrate real-time carbon dioxide signals from the energy grid into its solutions. This enables corporate clients, including climate regulators and sustainability directors, to visualize and co-optimize their energy usage and carbon emissions effectively. Singularity Energy's innovative approach combines data analytics with carbon forecasting and optimization algorithms, allowing organizations to minimize their emissions while maximizing economic benefits. The company's mission is to support entities in achieving their sustainability goals with transparency and confidence.

Worcester Polytechnic Institute (WPI), located in Worcester, Massachusetts, is a prestigious technological university founded in 1865. Renowned for its commitment to project-based learning, WPI emphasizes practical application of theoretical knowledge to address real-world challenges. The university boasts a distinguished faculty and state-of-the-art research facilities, fostering an environment rich in innovation and collaboration. WPI attracts ambitious students eager to engage in hands-on experiences that prepare them to make meaningful contributions to society. With a strong focus on developing skills that are crucial in today’s dynamic landscape, WPI positions itself as a leader in education and research, dedicated to empowering its students and faculty to achieve excellence.

Belmont Scientific is a chemical and battery safety technology company that specializes in process safety and risk management. The company was founded in 2011 and is based in Lowell, Massachusetts.

RaySecur Inc. is a company based in Cambridge, Massachusetts, focused on developing advanced 3D package scanning and imaging devices for detecting concealed threats in mail and parcels. Founded in 2018, RaySecur's MailSecur systems utilize millimeter-wave technology to provide real-time, three-dimensional imaging, which allows for the detection of powders, solids, liquids, and hazardous materials such as chemical, biological, radiological, and explosive composites. Unlike traditional X-ray systems, RaySecur's solutions are user-friendly, portable, and do not require extensive training for effective operation, making them suitable for various environments, including small mailrooms. The company’s technology is employed by Fortune 500 companies and government organizations worldwide to enhance security and protect personnel and assets from potential threats.

Ras Labs, LLC is a company that specializes in the development and production of Synthetic Muscle, a polymer-based material that mimics natural muscle movement through expansion and contraction in response to electric impulses. Founded in 2003 and headquartered in Quincy, Massachusetts, Ras Labs focuses on enhancing the interface between mechanical devices and humans. Its innovations are particularly beneficial in the fields of prosthetics, rehabilitative robotics, and protective devices. The company also manufactures robotic arm products that incorporate material science and data engineering to achieve precise motion in automation processes. These products feature tactile sensors that enable soft gripping of fragile objects, improving touch detection and location sensing in robotic grippers. Ras Labs aims to facilitate gentle grasping and adaptive responses in robotic applications, promoting more intuitive interactions between humans and machines.

DeepHealth, Inc. is a radiology artificial intelligence and machine learning company based in Cambridge, Massachusetts, founded in 2015. The company specializes in developing solutions for the medical interpretation of mammography exams, leveraging machine learning to translate extensive insights from medical experts into software that supports radiologists. DeepHealth aims to enhance patient care by creating reliable products grounded in rigorous science and clinical integration, ultimately assisting clinicians in making informed decisions.

Boston Children's Museum, founded in 1913 by the Science Teachers' Bureau, is the second oldest and one of the most influential children's museums globally. Located in Boston, Massachusetts, it operates as an independent non-profit organization dedicated to promoting the healthy development of all children. The museum engages young visitors through interactive exhibits and joyful discovery experiences that foster an appreciation for their world, develop essential skills, and inspire a lifelong love of learning. For over a century, it has served as a vital resource for teachers and families, contributing to the collective well-being and future prosperity of the community.

Sober Grid, Inc. is a digital health company that operates a sober social network aimed at supporting individuals in recovery from substance use disorders. Incorporated in 2015 and based in Boston, Massachusetts, the company has developed a mobile application available on both iOS and Android platforms. The app allows users to connect with others who are also navigating sobriety, fostering a community where they can share experiences and challenges. Sober Grid's platform is utilized in over 170 countries and has been accessed more than 20 million times. It integrates features such as GPS locator interfaces, direct messaging, and educational resources, while also offering certified coaching services available 24/7. The app employs a unique community-based approach to chronic disease management, utilizing predictive analytics to anticipate relapse risks and provide timely interventions. Sober Grid's commitment to improving health outcomes is supported by research collaborations with esteemed institutions like Harvard Medical School and the University of Pennsylvania, demonstrating its effectiveness in reducing relapse rates among users.

Infinite Cooling Inc. is a renewable and environmental technology company that specializes in water recovery systems for industrial-scale facilities, particularly power plants. Founded in 2017 and based in Somerville, Massachusetts, the company has developed an innovative technology that utilizes high-voltage electric fields to capture and recycle water that evaporates from cooling towers. This advanced method not only mitigates water scarcity but also significantly reduces water consumption and treatment costs for its clients. By focusing on wastewater management and recycling, Infinite Cooling addresses critical environmental challenges while promoting sustainable practices in industries such as power generation and manufacturing.

Elephant Stem develops a video game platform to assist students in learning statistics. The company is based in Cambridge, Massachusetts.

Heila Technologies, Inc. is a Massachusetts-based company that specializes in the development of a platform designed to integrate and optimize distributed energy resources (DERs) such as solar arrays and batteries. The Heila Platform employs a decentralized optimization system that simplifies the management of these resources, enabling the creation of self-managing microgrids. By transforming individual nodes within the energy system into intelligent agents, the platform facilitates autonomous coordination and optimization of power assets. This approach helps to reduce complexity and costs while enhancing resilience and efficiency in energy operations. Heila Technologies serves a diverse clientele, including partners, utility representatives, developers, energy users, and public officials. Originally founded as Heila Technologies LLC, the company was incorporated in 2015 and has its roots in MIT.

Ecto, established in 2013 at Harvard Innovation Labs by Dmitry Kozachenok and James Webb, specializes in developing advanced technology that intersects data and biology to enhance aquaculture efficiency and sustainability globally. Headquartered in Boston with offices in Atlanta and Stavanger, Norway, the company collaborates with farmers worldwide, offering a farm management platform that integrates operational data with molecular biology. This enables real-time insights, disease detection, and prevention, ultimately streamlining production processes and creating healthier protein servings. To date, Ecto's solutions have facilitated an additional 51.5 million healthy servings of protein. The company has been backed by competitive research grants from the US National Science Foundation, US Department of Agriculture, and Innovation Norway.

AmberWave, Inc. is a research and development company specializing in photovoltaic technology solutions for commercial buildings, as well as semiconductor manufacturing technologies. Founded in 1998, the company has developed a range of advanced materials and technologies, including Strained Silicon, which enhances microchip performance while reducing power consumption, and Aspect Ratio Trapping, used for silicon-based photonics and photovoltaic applications. AmberWave aims to provide high-value products for underrepresented markets and new applications, focusing on substrate engineering for integrated circuits, semiconductor lighting, and photovoltaics. The company is headquartered in Salem, New Hampshire, and was previously known as AmberWave Systems Corporation before changing its name in 2010.

Boston Microtechnology is a semiconductor company that specializes in the development of CMOS-integrated isolated AC/DC conversion. The company was founded in 2014 and is based in Burlington, Massachusetts.

University of Massachusetts Lowell is a high-ranking university, with several nationally recognized academic departments. Located about 30 minutes from Boston in Lowell, Massachusetts, UMass Lowell offers more than 100 degree programs at the undergraduate and graduate levels. UMass Lowell has several nationally recognized, research-oriented programs, including science and engineering. These programs undertake groundbreaking research and also provide exceptional work opportunities for its students and graduates. Other programs at UMass Lowell include liberal and fine arts, humanities, health-related programs, teacher education and social sciences. UMass Lowell also offers a range of internship opportunities for students who wish to gain experience in their field of study. Student life options at UMass Lowell include more than 100 diverse student organizations, leadership programs and community service opportunities. Lowell’s admissions policies are moderately competitive. Financial aid is available to eligible students through loans, academic scholarships and other sources to help cover tuition.

Metalmark Innovations, Inc. focuses on developing and delivering advanced 3D nanostructured coatings designed to treat airborne pollutants and toxins, enhancing indoor air quality. The company offers its innovative materials as additive coatings for various applications, including building materials and vehicle interiors, effectively addressing pollutants such as hydrocarbons, carbon monoxide, ozone, PM2.5, volatile organic compounds, odors, and germs. Its air cleaning technology employs catalytic materials that filter air with nanoscale precision, contributing to solutions for air pollution and climate change challenges. Founded in 2017 and headquartered in Boston, Massachusetts, Metalmark Innovations was previously known as Aircrew Technologies, Inc. before rebranding in January 2019.

Travera, LLC is a biotechnology company based in Cambridge, Massachusetts, founded in 2017. It specializes in cancer therapy guidance through its innovative measurement technology, utilizing the Suspended Microchannel Resonator (SMR). This advanced device functions as an extremely sensitive scale that can detect minute changes in the weight of individual cancer cells, specifically measuring the Mass Accumulation Rate (MAR) biomarker. By identifying rapid weight changes in response to cancer drugs, Travera enables oncologists to make informed decisions about which therapies to prescribe, based on the actual responses of patients' tumor cells. The technology is designed to differentiate between natural cell death and drug-induced cell death, providing timely and accurate insights that are critical for effective cancer treatment.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Helios Applied Science develops ultra-portable innovations for first-response rescue and humanitarian relief. The company is based in Hyde Park, Massachusetts.

3Derm Systems, Inc., based in Boston, Massachusetts, is a pioneering company in 3D dermatology that provides a specialized handheld skin imager and cloud-based software designed for capturing, storing, and transmitting high-resolution 3D images of the skin. Established in 2011, the company enables non-dermatologists to take clinical-quality skin images remotely, facilitating efficient monitoring of skin lesions by dermatologists. This innovative approach reduces healthcare costs, shortens wait times, and enhances access to dermatological care, particularly for the two million Americans diagnosed with skin cancer annually. By allowing patients to capture images from the comfort of their homes and upload them for review, 3Derm helps prioritize in-office appointments for those with more concerning conditions. The company's technology aims to transform teledermatology, offering a cost-effective solution that maintains the continuity of care with local dermatologists while ensuring high diagnostic quality. As of August 2020, 3Derm operates as a subsidiary of Digital Diagnostics, Inc.

Millimeter Wave Systems, founded in 2016 and headquartered in Amherst, Massachusetts, specializes in millimeter wave and microwave hardware solutions. The company develops a range of products, including subsystems, modules, components, and antennas, as well as advanced technologies such as cryogenic quantum-limited parametric amplifiers and latching junction ferrite circulators. These innovations are utilized in various applications, including medical scanners, sensors, automobile radars, and high data-rate communications. Millimeter Wave Systems aims to provide consistent quality in production while offering customizable solutions tailored to specific industry needs.

Gel4Med LLC is a Boston-based medical technology company founded in 2015, specializing in the development of innovative biomaterials for tissue treatment and regeneration. The company focuses on creating an antimicrobial tissue-scaffolding matrix that addresses the challenge of antibiotic-resistant bacteria while facilitating tissue regeneration. Utilizing bioinspired and engineering approaches, Gel4Med's technology aims to improve patient outcomes in various therapeutic areas, particularly in wound care and tissue regeneration. Their leading asset features a self-assembling peptide technology that acts as both an antibacterial barrier and a promoter of tissue regeneration, enabling patients to prevent infections during surgical procedures.

Root AI, Inc. is a Woburn, Massachusetts-based company that develops artificial intelligence-powered robots specifically designed for indoor farming. Founded in 2018 by Joshua Lessing and Ryan Knopf, Root AI focuses on creating intelligent robotics that assist growers in building advanced agricultural systems. The company’s flagship product, the Virgo 1, is an autonomous robot capable of harvesting tomatoes without causing bruising and is equipped with advanced vision systems to better assess ripeness than human workers. Root AI aims to enhance efficiency in indoor farming, enabling growers to produce high-quality, chemical-free produce while optimizing operational processes.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

NanoView Biosciences is a medical technology company focused on the detection and characterization of extracellular vesicles, particularly exosomes, through its proprietary ExoView technology. Founded in 2015 and headquartered in Boston, Massachusetts, the company offers a range of products, including the ExoView R100 and ExoView Tetraspanin, as well as related kits and custom assays. NanoView's high-throughput, cost-effective analysis solutions provide life science researchers with critical insights into the biological roles of exosomes, enhancing the understanding of their potential as biomarkers for disease diagnosis, treatment, and monitoring. The company's platform is capable of analyzing nanoparticles from complex biological samples such as whole blood, serum, plasma, and urine, thereby supporting advancements in precision medicine.

Embr Labs Inc. is a thermal wellness technology company based in Somerville, Massachusetts, that specializes in developing and selling wearable devices designed to adjust body temperature for enhanced comfort. Originally founded as Wristify Inc. in 2014, the company rebranded in 2015. Embr Labs leverages patented technology to utilize thermal sensations as a means to influence the autonomic nervous system, aiding individuals in managing conditions such as hot flashes, sleep disturbances, and anxiety. The company's innovative approach combines thermal stimulation with digital interventions through a mobile app and cloud infrastructure, creating a comprehensive platform for users. With tens of thousands of customers across 170 countries, Embr Labs has recorded over 100 million minutes of thermal interventions. The technology was conceived by its founders while they were engineering students at MIT, and the company has received significant backing from various investors and grants.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Elektrofi is a preclinical-stage company based in Boston, Massachusetts, focused on revolutionizing drug delivery to enhance patient experiences. Founded in 2016, Elektrofi specializes in a formulation system capable of processing a broad spectrum of therapeutic molecules, including large and complex proteins such as monoclonal antibodies, bispecifics, and fusion proteins. The company's technology aims to improve subcutaneous administration, enabling drug manufacturers to create innovative therapies that offer patients greater control over how they receive life-changing medicines.

The University of Massachusetts Amherst is a public research and land-grant university that offers undergraduate, master's, and doctoral programs. It serves as the flagship campus of the University of Massachusetts system. The university has multiple academic departments and research facilities that support a range of disciplines.

KnipBio Inc., established in 2013 and headquartered in Lowell, Massachusetts, specializes in developing sustainable biotechnology solutions for animal nutrition, particularly within the aquaculture industry. The company's flagship product is KnipBio Meal (KBM), a single-cell protein derived from microbe strains that convert abundant, low-cost feedstocks into nutritious alternatives to traditional fishmeal. This innovative approach aims to address real-world challenges in aquaculture feed while promoting responsible and sustainable practices.

AI Strike provides big data and AI technology solutions and decision support systems that improve the bottom line of clients. The company's headquarters are in Shrewsbury, Massachusetts.

Leading Edge Equipment Technologies, Inc. is a manufacturer and supplier of advanced equipment for solar panel production, specializing in single-crystal silicon wafers. Established in 2008 and based in Wilmington, Massachusetts, the company has developed a kerfless method that significantly reduces the costs associated with producing silicon wafers while increasing the efficiency of solar panels. This innovative process eliminates the need for wire-sawing large silicon ingots and utilizes less energy-intensive furnaces, resulting in higher efficiency solar cells and reduced carbon emissions. By offering a solution that integrates seamlessly into existing manufacturing processes, Leading Edge Equipment Technologies enables solar cell and panel manufacturers to enhance their products' power output without requiring substantial changes to their operations. The company, which rebranded from Leading Edge Crystal Technologies in May 2020, continues to advance technologies that support the growth of sustainable energy solutions.

Realtime Robotics, Inc. is a Boston-based company founded in 2016 that specializes in developing motion planning and control technologies for robots and autonomous vehicles. The company offers a collision-free motion planning platform that allows robots to react instantaneously to their surroundings, enabling safe operation in unstructured environments. Their RapidPlan processor integrates advanced software and hardware, allowing for the generation of safe motion plans in milliseconds, effectively eliminating the trade-off between speed and safety in automation. By facilitating seamless interaction with both static and dynamic objects, Realtime Robotics enhances the capabilities of robots in various applications, including industrial automation and autonomous vehicles, thereby promoting broader adoption and integration of robotics technology in everyday operations.

Articulate Biosciences is a preclinical stage medical device company founded in 2016 as a spinout from Boston University. The company focuses on developing injectable viscoelastic gels aimed at treating arthritis and other soft tissue diseases. These gels are formulated with tissue-protecting and function-restoring biomedical polymers, which are designed to alleviate chronic joint pain and enhance mobility for patients suffering from osteoarthritis. Through its innovative approach, Articulate Biosciences seeks to provide effective pain relief and improve the quality of life for individuals affected by these conditions.

Boston Materials, Inc. is a manufacturer of advanced composite materials based in Bedford, Massachusetts, founded in 2016. The company specializes in producing 3D reinforced carbon fiber pre-pregs and offers a patented Z-axis Fiber technology that incorporates vertically aligned carbon fibers. This innovative approach enhances the thermal, electrical, and mechanical properties of materials, making them suitable for various high-growth industries, including semiconductors, aerospace, automotive, and renewable energy. Boston Materials' products are designed to improve performance, efficiency, and reliability while addressing challenges related to durability and weight reduction. The company employs a roll-to-roll manufacturing process with in-line quality control, achieving an annual production capacity of one million square meters.

Ernest Pharmaceuticals is a biotechnology company founded in 2016 and based in Hadley, Massachusetts. The company specializes in developing innovative bacterial therapeutics aimed at treating cancer. Its unique approach involves the use of programmed bacteria that are engineered with synthetic techniques to deliver intracellular macromolecules. These motile bacteria actively penetrate tumor tissue, which enhances their ability to target metastatic disease and inoperable tumors. By focusing on this novel method of cancer treatment, Ernest Pharmaceuticals seeks to advance therapeutic options for patients facing difficult-to-treat malignancies.

KnipBio Inc., established in 2013 and headquartered in Lowell, Massachusetts, specializes in developing sustainable biotechnology solutions for animal nutrition, particularly within the aquaculture industry. The company's flagship product is KnipBio Meal (KBM), a single-cell protein derived from microbe strains that convert abundant, low-cost feedstocks into nutritious alternatives to traditional fishmeal. This innovative approach aims to address real-world challenges in aquaculture feed while promoting responsible and sustainable practices.

Anfiro, Inc. is a water technology start-up based in Cambridge, Massachusetts, founded in 2014. The company specializes in developing advanced reverse osmosis membranes using self-assembling polymers that are both chlorine resistant and exhibit ultra-high permeability. These innovative membranes significantly enhance the efficiency of water purification and desalination processes, allowing for reduced energy requirements and lower operating costs. By addressing the critical issue of global freshwater scarcity, Anfiro aims to provide clean and affordable water solutions, thereby contributing to a more sustainable future.

GelSight, Inc. is a technology company based in Waltham, Massachusetts, focused on developing advanced sensor solutions for precise surface measurements. Founded in 2011, GelSight specializes in a unique sensor technology that captures the 3D topography of various rigid materials, providing detailed surface geometry and dimensional measurements with precision down to single-digit microns. Its flagship product, the GelSight benchtop scanner, is designed to meet the diverse needs of industries such as aerospace, electronics, ballistics, and metrology, as well as applications in universities and forensics. The company's innovative approach allows for flexible measurements across a wide range of scales, enabling clients to obtain highly accurate and reliable 3D data that reveals intricate surface details not visible to the naked eye.

Neurable Inc. is a neurotechnology company based in Cambridge, Massachusetts, established in 2016. The company specializes in developing artificial intelligence software that allows users to control software and devices using their brain activity. By leveraging patented signal processing techniques and a multidisciplinary approach that combines neuroscience, biology, statistics, and machine learning, Neurable creates high-performance brain-computer interfaces. These interfaces enable users to interact with various applications, such as playing games, operating toys, and even driving vehicles, through their brain signals. Neurable's technology is also applicable in virtual and augmented reality environments, offering innovative solutions for enhancing user experience and interaction.