National Science Foundation

PediaMetrix is a pediatric health technology company that develops AI-powered cranial measurement and monitoring tools to detect and manage head shape abnormalities in newborns. Its SoftSpot platform provides quantitative cranial measurements via a smartphone app, enabling at-home and in-office use, and offers data-driven guidance and repositioning instructions for parents. The system also gives pediatricians access to simplified analysis and data from the app to support clinical decisions, and is supported by FDA-cleared digital tools for pediatric head assessment. Founded in 2018, the company is based in Rockville, Maryland, and leverages computer vision and artificial intelligence to lower healthcare costs and improve outcomes in pediatric head care.

LiteraSeed is a digital health company that has created a clinically validated platform aimed at enhancing communication between patients and healthcare providers. This platform is specifically designed to assist low health literate patient populations, which includes individuals who may face language barriers or have difficulty articulating their health concerns. By facilitating accurate and remote self-reporting of symptoms, LiteraSeed's technology seeks to prevent misdiagnoses, adverse health events, and unnecessary emergency room visits. The company's focus on improving access to care is particularly beneficial for public health providers serving diverse communities, ensuring that disadvantaged patients receive the attention and resources they need for effective healthcare management.

Nanopath is a molecular diagnostics company that develops innovative platforms for rapid disease diagnosis. Its technology enables point-of-care testing, eliminating the need for nucleic acid amplification and supporting multiplexed detection. This allows patients and healthcare providers to access accurate diagnostic results within standard office visits, improving healthcare outcomes.

The Wistar Institute is a leading independent biomedical research institution dedicated to advancing medical knowledge through innovative research and training. Established as the first of its kind in the United States, it has grown from an anatomical teaching museum into a prominent center for basic biomedical research. Designated as a National Cancer Institute Cancer Center in 1972, The Wistar Institute focuses on critical areas such as cancer, immunology, and infectious diseases. Its groundbreaking discoveries have contributed to the development of vaccines for diseases like rabies, rubella, and rotavirus, as well as the identification of genes related to breast, lung, and prostate cancer. The Institute promotes a collaborative research environment aimed at addressing some of the most pressing challenges in the biomedical field.

Amplified Sciences is a molecular diagnostics company developing a point-of-care platform that enables early detection of debilitating diseases. Its sensor-based and optical reporter systems, combined with machine learning and multi-analyte assays, target cancers and chronic conditions such as pancreatic cancer and kidney disease. The technology supports detection of low-abundance disease markers in urine and saliva, with scalability to cost-effective point-of-care formats. The company leverages ultra-sensitive sensing and composition-of-matter intellectual property licensed from Purdue University to deliver single-molecule level detection. Its portfolio aims to improve patient outcomes by enabling rapid, minimally invasive testing, reducing unnecessary procedures, and expediting diagnosis across oncology and other disease areas. The platform has demonstrated prototype data and is positioned for broad applicability across multiple disease states.

Astria Biosciences, based in Pittsburgh, specializes in developing innovative diagnostic and therapeutic solutions for cerebrovascular diseases. The company focuses on addressing neurosurgical challenges through molecular biology, advanced analytics, and small-molecule inhibitors, aiming to provide non-surgical alternatives for neurovascular conditions where surgery is currently the primary option.

CenSyn develops a portable brain health assessment platform. It comprises a handheld EEG device for rapid neurological evaluation, a mobile app for real-time data viewing, and machine learning algorithms to detect mental status changes. This enables medical professionals to conduct cognitive assessments across various settings.

Avisi Technologies Inc. is a Philadelphia-based company founded in 2017 that specializes in developing innovative solutions for glaucoma treatment. Its primary product, VisiPlate, is a next-generation, nanotechnology-enabled aqueous shunt designed to prevent blindness caused by glaucoma. Through its advanced technology, Avisi Technologies aims to enhance the effectiveness of glaucoma management and improve patient outcomes.

Samay specializes in remote respiratory health management. It develops AI-enabled wearable devices that monitor pulmonary volumes, trapped air, heart rates, breathing sounds, and lung temperature. This enables users to analyze their respiratory data and helps prevent respiratory diseases.

MALCOVA develops medical imaging devices focused on early detection and diagnosis of breast cancer in women with dense breasts. It leverages proprietary Narrow-Beam Computed Tomography technology and AI-based software to deliver safe, rapid, high-quality imaging.

ProMedix is a medical device startup based in Portland, Oregon, founded in 2019. The company specializes in the development of noninvasive, fingertip patient monitors aimed at enhancing the recognition of circulatory dysfunction. Its innovative devices are designed to assist in the diagnostic evaluation and monitoring of various medical conditions, such as trauma, dehydration, and sepsis. By facilitating effective home patient monitoring, ProMedix aims to simplify both home and critical care, helping physicians to prevent unnecessary acute visits and improve overall emergency and critical care outcomes.

Metfora is a company focused on developing advanced blood test services aimed at the early detection of chronic lung and heart disorders, as well as various cancers. By utilizing artificial intelligence, Metfora analyzes patterns in circulating metabolites within patients' blood samples. This innovative approach enables the identification of diseases at their initial stages, allowing healthcare professionals to diagnose serious conditions even when symptoms are minimal. The company's commitment to enhancing early diagnostic capabilities positions it as a key player in the field of medical testing, ultimately aiming to improve patient outcomes through timely intervention.

BLOCKsyncop is a company focused on developing innovative clinical monitoring devices aimed at enhancing anesthesiology practices. Its primary product is a non-invasive, real-time tool designed to objectively measure and quantify the effectiveness of neural blocks for pain management. This technology assists anesthesiologists in reducing the occurrence of failed neural blocks, minimizing anesthetic toxicity, and optimizing the analgesic requirements for patients. By providing precise data, BLOCKsyncop aims to improve patient outcomes in pain management and support healthcare professionals in delivering safer and more effective anesthesia care.

Vivifi Medical develops a laparoscopic device that enables quick connection of two blood vessels. Headquartered in Houston, Texas.

Moshion is a technology company specializing in healthcare workflow optimization, specifically targeting the nursing shortage. It employs 3D image sensors, preserving patient privacy, to gather movement data, which is then analyzed using machine learning models. Moshion's primary focus is to prevent pressure injuries in bedridden patients by monitoring and optimizing patient turning protocols. The platform tracks adherence to these protocols, provides personalized turn schedules, sends reminders to nurses, and automates documentation. This data-driven approach aims to enhance patient care, improve nursing efficiency, and reduce the risk of life-threatening events.

OmniVis is a biotechnology company specializing in pathogen detection. It offers an integrated portable platform that rapidly and accurately identifies pathogens in various environments, reducing the need for labor-intensive lab testing.

Atom Bioworks is a biotechnology company that focuses on developing a pattern-recognition-enabled platform for sensing and therapeutic applications targeting infectious diseases and cancer. By utilizing advanced methodologies in computational biology, quantum chemistry, software, and machine learning, the company captures the surface protein patterns associated with diseases. This innovative approach allows for the creation of pattern-matching constructs, providing researchers with enhanced capabilities in nano-pattern recognition. Atom Bioworks aims to facilitate early diagnosis and treatment, thereby contributing to advancements in medical applications.

CPR Therapeutics is a medical device company focused on developing an advanced automated cardiopulmonary resuscitation (CPR) system. The company's innovative technology integrates multiple technological advancements into a single system designed for easy application under emergency conditions. This multimodal CPR system enhances blood flow and the efficacy of electrical countershock, capabilities that are beyond human performance. By combining chest compressions with artificial ventilation, the system aims to preserve brain function and restore spontaneous circulation and breathing in cardiac arrest patients, thereby improving survival rates significantly.

Scopi Medical is a mission-driven company focused on advancing medical optical imaging technology for clinics. By developing a sophisticated hardware platform complemented by state-of-the-art artificial intelligence and machine learning software, Scopi Medical aims to enhance the accuracy of point-of-care diagnostics. Their innovative imaging devices enable practitioners to diagnose and monitor chronic nasal conditions, such as rhinosinusitis, with greater precision and at an earlier stage than traditional methods allow. Additionally, their technology facilitates remote collaboration between healthcare providers and specialists, ensuring that areas of concern can be visualized and treated effectively, ultimately improving patient outcomes.

Claria Medical is a pre-commercial medical device start-up focused on addressing unmet needs in women's healthcare, particularly in gynecologic surgery. The company specializes in the development of minimally invasive surgical tools designed to enhance procedures such as hysterectomy and myomectomy. Claria Medical has achieved early recognition for its innovative approach, receiving a "Safer Technologies Designation" from the U.S. Food and Drug Administration. Additionally, the company has secured funding through private financing, as well as prestigious grants from the National Science Foundation and the National Institutes of Health, to support the advancement of its medical devices aimed at improving surgical outcomes for women.

CardioPhi is an artificial intelligence company developing tools for automatic and reliable interpretation of electrocardiograms to assist clinicians in diagnosing and managing cardiac arrhythmias. By applying AI to heart function data, CardioPhi aims to improve patient outcomes and reduce public spending on cardiovascular diseases through faster, more accurate ECG analysis and clinical decision support.

BrilliantMD is a company specializing in claims management services aimed at the healthcare sector. It develops advanced software designed to address issues related to claims denials. Utilizing artificial intelligence, machine learning, blockchain technology, and advanced analytics, BrilliantMD's software enhances transparency in healthcare data and the claims process. This innovative approach enables healthcare providers to improve revenue outcomes and make informed, data-driven decisions. By transforming the claims management landscape, BrilliantMD aims to streamline operations and enhance efficiency within the healthcare industry.

ControlPoint is an animal diagnostics company dedicated to enhancing animal health and wellness worldwide. The company specializes in developing rapid testing methods for multiple pathogens, particularly in relation to canine respiratory diseases such as kennel cough. By providing veterinarians with fast and accurate test results, ControlPoint enables pet owners to make informed decisions about their pets' health, ultimately improving the quality of care and the everyday lives of animals.

Samay specializes in remote respiratory health management. It develops AI-enabled wearable devices that monitor pulmonary volumes, trapped air, heart rates, breathing sounds, and lung temperature. This enables users to analyze their respiratory data and helps prevent respiratory diseases.

Oculogenex is a biopharmaceutical company founded in 2020 and based in La Habra, California. It specializes in the development of gene therapies aimed at treating retinal disorders. The company’s innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced cell death, a condition linked to macular degeneration. By focusing on these therapies, Oculogenex seeks to enable researchers to enhance the detection and treatment of retinal-related disorders, contributing significantly to advancements in this critical area of medical research.

Qualia Oto is a biomedical device company based in Dallas, Texas, founded in 2017. The company specializes in advanced cochlear implant technology, utilizing innovative shape-changing polymers and matrix-addressed electrode arrays to create high-quality devices tailored to individual medical and personal needs. Qualia Oto's technology aims to enhance auditory nerve stimulation through higher channel count cochlear implants and auditory brainstem implants, with future plans to incorporate machine learning-based stimulation for more precise outcomes.

Aqua Science offers a global platform of technologies and fast and reliable solutions for the testing and treatment of water. They provide research and development, custom reagent and kit manufacture, product assembly, lyophilization services, and contract manufacturing services.

Oxalo Therapeutics develops therapies to treat rare kidney diseases and prevent recurrent oxalate-related stones, focusing on primary hyperoxaluria and other oxalate pathologies. It leverages microbiome science, translational research, and early-stage technology to create a gut-derived therapy that safely removes oxalate from the body, reducing stone recurrence and related renal complications.

Uniphage is a biotechnology company specializing in the development of safer and more efficient alternatives to traditional pesticides in plant agriculture. It leverages artificial intelligence and bacteriophages (viruses that infect bacteria) to predict and combat specific bacterial infections. The company's primary focus is on citrus greening, a devastating disease costing the U.S. over $2 billion annually. By employing AI algorithms, Uniphage accelerates the discovery of effective and safe bacterial viruses, aiming to reduce the use of harmful fungicides, bactericides, and antibiotics, thereby minimizing risks to human health and the environment.

AmCyt is a company focused on enhancing pathological analysis through the development of a rapid onsite diagnostic device. This innovative technology streamlines the biopsy process by allowing for the smearing of tissue samples onto glass slides, followed by staining and real-time microscopic evaluation. By improving the efficacy of biopsies, AmCyt addresses labor shortages in clinics and hospitals, ultimately leading to better patient outcomes. The company's solutions aim to reduce the need for additional sampling and minimize the risk of complications associated with procedures, thereby saving time, money, and resources for healthcare providers.

EzraBio is a biotechnology company focused on enhancing ribosome profiling for researchers across various biological samples. The company specializes in RNA adenylation technology, which facilitates efficient and rapid cDNA library construction. By offering streamlined services that encompass sample preparation and deep sequencing, EzraBio aims to simplify the ribosome profiling process. This innovative approach allows medical professionals to uncover hidden coding potential, analyze translational responses, identify tumor-associated antigens, and advance mRNA therapeutics. Through its cutting-edge solutions, EzraBio supports researchers in their quest to deepen understanding of complex biological mechanisms.

AccuBreath specializes in developing innovative respiratory care solutions. Their flagship product is an affordable, high-end, ultraportable ventilator designed for gentle and portable respiratory support during medical procedures.

Strados Labs, LLC is a medical technology company based in Philadelphia, Pennsylvania, specializing in respiratory health management through innovative sensor-based solutions. Founded in 2016, the company has developed a wearable device that provides real-time insights into breathing patterns, sounds, and speed. This device is equipped with clinical-grade biosensors and smart software, allowing for continuous monitoring of respiratory conditions such as asthma and chronic obstructive pulmonary disease. By connecting to a mobile application, Strados enables users and healthcare providers to access and analyze respiratory data, facilitating informed health decisions and remote patient monitoring.

Ai-Ris offers automated retinal examinations for primary care. Their retinal imaging system allows general practitioners to screen for diabetic retinopathy without the presence of a specialist. This system consists of a portable headset that uses machine learning algorithms to classify images of the retina of patients without dilating their pupils.

Secure Food Solutions Inc., established in 2014 and based in Martin, Tennessee, specializes in enhancing global food safety by developing advanced detection technologies for toxins, pathogens, and contaminants. The company's core offering is a patented hyperspectral imaging technology designed to swiftly identify corn contaminated with aflatoxin, aiming to improve food quality and safety worldwide.

RaySecur Inc. is a company based in Cambridge, Massachusetts, focused on developing advanced 3D package scanning and imaging devices for detecting concealed threats in mail and parcels. Founded in 2018, RaySecur's MailSecur systems utilize millimeter-wave technology to provide real-time, three-dimensional imaging, which allows for the detection of powders, solids, liquids, and hazardous materials such as chemical, biological, radiological, and explosive composites. Unlike traditional X-ray systems, RaySecur's solutions are user-friendly, portable, and do not require extensive training for effective operation, making them suitable for various environments, including small mailrooms. The company’s technology is employed by Fortune 500 companies and government organizations worldwide to enhance security and protect personnel and assets from potential threats.

Hypersound Medical is focused on developing non-invasive neuromodulatory devices that utilize neurostimulation techniques to address chronic pain conditions. The company's products employ microwave energy to stimulate nerve cells, offering pain relief for various ailments, including arthritis, back pain, and neuropathic pain. By enhancing pain management, Hypersound Medical aims to improve patient function and reduce reliance on pain medication. Their approach encompasses various stimulation methods, such as peripheral nerve stimulation and spinal cord stimulation, positioning the company as a key player in the field of pain relief technology.

Lura Health develops a non-invasive continuous health monitoring platform that uses saliva as a diagnostic fluid. The company integrates micro-sensors into orthodontic devices such as retainers, aligners, and brackets to continuously measure saliva analytes and securely transmit data to a smartphone app, enabling users to monitor oral health metrics and potentially support broader chronic disease management. Target markets include heart disease, chronic kidney disease, diabetes, and tooth decay. Founded in 2017, the company is based in Cambridge, Massachusetts.

Acrigen Biosciences is focused on advancing gene editing technologies to enhance the safety and efficiency of CRISPR-Cas based systems. Founded in 2019 and headquartered in Berkeley, California, the company develops precision gene editing solutions aimed at producing effective and safe in vivo drug therapies for various diseases. Acrigen's innovations include Acro proteins that regulate the CRISPR-Cas gene editing process, along with a bioinformatics discovery software platform designed to identify suitable CRISPR systems for human therapeutic applications. By improving anti-CRISPR proteins and optimizing genetic therapies, Acrigen aims to contribute significantly to the field of medicine and the treatment of debilitating conditions.

Zsense Systems specializes in the development of fluid condition-monitoring systems that provide lab-quality diagnostics in field applications. The company focuses on integrating technology and communications within critical fluid and lubrication systems. Through their engineering services and condition monitoring solutions, Zsense aims to enhance the reliability and performance of these systems, allowing clients to optimize equipment uptime, effectively manage maintenance, repair, and operations costs, and minimize the risk of equipment failure. By leveraging expertise in areas such as inductive pulse technology, oil analysis, and data science, Zsense delivers innovative solutions tailored to the needs of its customers.

UCHU Biosensors develops a platform of tooth mounted sensors to effortlessly track health through saliva.

GeniPhys develops and commercializes standardized tunable collagen polymers and collagen-fibril materials for research and medical applications. It manufactures research-grade collymers and polymerization reagents that enable customization of 3D collagen-fibril matrices for in-vitro tissue systems used in drug discovery, toxicity testing, and basic cell and tissue research, as well as engineered tissue and organ constructs and 3D bioprinting. The product line includes oligomer polymerization kits, polymerization buffers, supplements, and related reagents, which are sold online. Founded in 2014 and based in Zionsville, Indiana, the company focuses on designing collagen materials for site-appropriate tissue generation and potential delivery of pharmaceutical and cell-based therapies.

Taurus Diagnostics is a health-tech company focused on enhancing the diagnostic process for men suspected of having prostate cancer. The company leverages data-centric artificial intelligence to improve the accuracy of magnetic resonance imaging (MRI), minimizing the need for unnecessary biopsies. Its advanced AI algorithm has been trained on a vast array of patient data to reliably identify lesions indicative of prostate cancer. This technology empowers physicians to effectively pinpoint patients who are most in need of a biopsy and provides clear visualizations of lesion locations, thereby streamlining the diagnostic process and improving patient outcomes.

Isolere Bio, established in 2018, is a healthcare company specializing in biotherapeutic purification. Its core business involves simplifying and optimizing the manufacturing process of monoclonal antibodies and Adeno-Associated Viruses (AAVs) using Tangential Flow Filtration (TFF) technology. This streamlined approach aims to enhance global access to these vital drugs and research tools, while facilitating a seamless transition from laboratory-scale production to industrial-level output.

SafeBVM develops a medical device accessory designed to prevent hyperventilation during manual resuscitation. Its product, Sotair, uses a flow-blocking valve mechanism to regulate airflow and reduce complications such as stomach insufflation and respiratory distress.

PediaMetrix is a pediatric health technology company that develops AI-powered cranial measurement and monitoring tools to detect and manage head shape abnormalities in newborns. Its SoftSpot platform provides quantitative cranial measurements via a smartphone app, enabling at-home and in-office use, and offers data-driven guidance and repositioning instructions for parents. The system also gives pediatricians access to simplified analysis and data from the app to support clinical decisions, and is supported by FDA-cleared digital tools for pediatric head assessment. Founded in 2018, the company is based in Rockville, Maryland, and leverages computer vision and artificial intelligence to lower healthcare costs and improve outcomes in pediatric head care.

Alienbyte specializes in the provision of medical images and their corresponding labels, essential for advanced analysis of human and animal anatomy as well as for training artificial intelligence algorithms. The company has developed a web application that facilitates the labeling of three-dimensional tomographic images. This application includes a user-friendly web interface and tools for creating and managing labels, enhanced by artificial intelligence-assisted labeling techniques. By employing algorithmic methods, Alienbyte aims to streamline the labeling process, thereby increasing the utility of medical images for researchers, healthcare professionals, and patients.

Auctus Biologics is a pre-clinical biotechnology company focused on developing innovative antibody mimetics for therapeutic and diagnostic uses. The company is engaged in creating a ribose-binding protein designed to bind clinical targets with a high affinity, similar to monoclonal antibodies, while overcoming the limitations associated with traditional antibodies. These limitations include instability, the need for costly cold-chain management, and challenges with administration in extreme environments such as the gastrointestinal tract. By engineering their mimetic scaffold to withstand repeat boiling cycles, Auctus Biologics aims to facilitate advanced treatment options that reduce costs and improve the accessibility of biologic therapies for patients.

Reselute specializes in designing, developing, and validating innovative medical devices. Their primary focus is on creating orthopaedic spacers that enhance the treatment of implant-related infections, enabling healthcare professionals to accelerate recovery and improve patient care.

BiRed Imaging specializes in advanced medical imaging technology focused on the early detection of breast cancer. The company has developed an innovative platform that combines infrared imaging with a proprietary computerized detection algorithm, enabling accurate identification of the size and location of tumors, particularly in patients with dense breast tissue. This technology serves as an effective adjunct to traditional breast cancer screening methods, helping clinicians to recognize high-risk patients at an early stage. By enhancing the accuracy and cost-effectiveness of breast cancer detection, BiRed Imaging aims to improve patient outcomes in oncology.

PZA Innovation is a biotechnology company focused on improving tuberculosis treatment through the development of a reliable pyrazinamide susceptibility testing method. By employing reverse engineering techniques, the company identifies the specific conditions under which pyrazinamide demonstrates effectiveness in vitro, targeting the living environment of mycobacterium tuberculosis within the host. This innovative approach aims to enable healthcare professionals to deliver next-generation pyrazinamide therapies, ultimately shortening the duration of tuberculosis treatment and enhancing patient outcomes.

CereVu Medical specializes in developing advanced medical devices. Their primary product is a wearable, single-use forehead patch connected to a reusable console, designed to monitor and analyze cerebral hemodynamics in real-time. This system employs proprietary algorithms to provide continuous pain score assessments, enabling healthcare professionals to tailor treatments based on individual patient needs.

IntuiTap Medical is a medical device company that develops a handheld system to guide spinal puncture procedures. The device aims to eliminate guesswork, frustration, and pain associated with spinal taps by integrating spine imaging, needle guidance, and analytics to enable accurate needle placements for lumbar punctures, spinal anesthesia, and epidurals. The system seeks to improve procedure efficiency and reduce costs while enhancing clinician confidence and patient experience. The company was founded in 2016 and is headquartered in Houston, Texas.

Nanopath is a molecular diagnostics company that develops innovative platforms for rapid disease diagnosis. Its technology enables point-of-care testing, eliminating the need for nucleic acid amplification and supporting multiplexed detection. This allows patients and healthcare providers to access accurate diagnostic results within standard office visits, improving healthcare outcomes.

QuadraLynx is a company focused on developing wearable biometric devices aimed at enhancing speech and voice for adults with motor speech disorders. Particularly, their technology targets individuals experiencing volume control issues, a common challenge associated with Parkinson's disease and similar neurological conditions. The wearable, battery-operated device provides users with real-time feedback by vibrating when their voice reaches a pathological state, thereby assisting in improving communication and overall quality of life for those affected by these disorders. Through its innovative approach, QuadraLynx seeks to make a meaningful impact on the daily lives of its users.

Astek Diagnostics is a healthcare company that develops precision diagnostic technology aimed at improving the diagnosis and treatment of bacterial infections. The company has created a platform that assists physicians in prescribing the correct antibiotics for patients suffering from bacterial sepsis within one hour. Utilizing a single-use cartridge, Astek Diagnostics' device identifies bacterial infections in urine by measuring the oxygen consumption of bacterial species, significantly reducing the turnaround time for results. This innovative approach not only facilitates timely treatment but also helps combat antibiotic resistance through effective susceptibility testing.

EchoWear is a company focused on enhancing healthcare access through its innovative smartwatch-based system. This system facilitates meaningful interactions between patients and care teams, promoting the development of actionable digital health services. By prioritizing age-friendly health technologies, EchoWear aims to improve the overall healthcare experience for users, ensuring that they can effectively engage with their health management through digital solutions.

ExciPlex specializes in developing advanced diagnostic systems for the detection of mycotoxins in animal feed and feed inputs. The company's innovative technology includes a portable spectrometer that can operate both online and offline, enabling real-time quantification of mycotoxins across various feed types, including grains, finished feeds, silages, and forages. This capability allows farmers to monitor and ensure the safety of their feed products, enhancing traceability throughout the production process. By providing immediate feedback via mobile devices and web platforms, ExciPlex aims to mitigate the adverse effects of mycotoxins on animal health and productivity.

OPOS specializes in opioid treatment for patients, ensuring regulatory compliance. Its platform reduces administrative burden, minimizes prescribing risks, and optimizes patient outcomes by providing clinical decision support.

Pragma Health provides digital healthcare services. They permit users to perform different tests for cardiovascular, hematology, infectious diseases, and others in the privacy of their home and provide accurate, immediate results, enabling them to get a convenient, cost-effective, and accurate healthcare testing process.

The Wrightguard specializes in the development of innovative smart mouthguards tailored for athletes. These mouthguards are equipped with advanced sensors and wireless communication technology that gather real-time biometric data, enabling the monitoring of both health and performance. This technology aims to enhance athlete safety by ensuring consistent placement and uniform thickness of shock-absorbing materials, providing effective protection during sports activities. Wrightguard's products offer an affordable dental solution, making it easier for athletes to prioritize their safety while competing.

Envivo Bio develops a non-invasive device that collects microbiome samples from all regions of the human gastrointestinal tract. The company is based in San Carlos, California.

Clairways is a developer of innovative wearable technology focused on lung health monitoring, specifically designed for use in pharmaceutical clinical trials. The company's digital lung function monitor captures essential respiratory metrics for individuals suffering from chronic respiratory diseases such as asthma, COPD, and cystic fibrosis. This device is equipped with acoustic sensors and machine learning technology, allowing it to detect and characterize various respiratory metrics. By presenting this data in a clear and understandable format, Clairways enables healthcare professionals to monitor patients' respiratory conditions effectively and gain a comprehensive, long-term perspective on their respiratory health.

Felix Biotechnology, Inc. is a San Francisco-based company founded in 2019 that specializes in developing biotherapeutics to combat microbial challenges in human health. The company focuses on creating treatments for antibiotic-resistant strains of bacteria and fungi, aiming to address the urgent need for effective management of infectious diseases. By accelerating the deployment of novel biotherapeutics, Felix Biotechnology seeks to provide healthcare professionals with precise and effective tools to tackle these pressing health issues.

Labby Inc. is a technology company based in Cambridge, Massachusetts, specializing in smartphone-based optical spectrometry for agricultural applications. Founded in 2017, Labby develops an artificial intelligence-driven platform that translates raw optical data into actionable insights, primarily for farmers and dairy processors. Its flagship product allows for rapid and precise testing of milk composition, facilitating early mastitis detection and enabling timely intervention. Additionally, Labby's technology is applicable across various sectors, including the detection of spoilage, adulterants, and contamination in the supply chain, as well as providing analytics for tracking harvest cycles and meteorological data mapping. The company also caters to the beer and wine industries, offering portable testing devices for quality control and counterfeit detection, serving a diverse clientele that ranges from large breweries to homebrewers.

Lelantos develops IoT-compatible gas sensors using MEMS resonator arrays on CMOS silicon microchips. These sensors consume less power and cost less than current technologies, offering superior detection performance for applications such as threat detection, industrial safety, environmental monitoring, and medical diagnostics.

Biochip Labs is a company based in Cleveland, Ohio, founded in 2019. It specializes in providing laboratory testing services focused on blood disorders, particularly sickle cell disease and thalassemia. The company offers a range of proprietary microfluidic biomarker assays, including tests for blood cell adhesion, red blood cell deformability, whole blood rheology, and endothelialized microfluidics. These assays are designed to evaluate the effectiveness of emerging targeted and curative therapies, allowing clinicians to monitor patients' responses to treatment accurately.

Synopic is focused on developing advanced imaging technology aimed at enhancing visualization and decision-making in medical procedures. The company specializes in creating depth-enabled cameras that provide measurable 3D information, particularly for applications like endoscopy and other minimally invasive procedures where instrument size is critical. By employing a single-camera design, Synopic addresses the limitations of existing imaging solutions, offering a compact, high-resolution camera capable of capturing depth information and color images that were previously unattainable due to space constraints. This innovative approach allows for improved visualization and data quality, ultimately supporting medical professionals in making more informed decisions during complex procedures.

Niche Biomedical is a platform and therapy development firm that specializes in innovative treatments for chronic injuries and disorders that have not responded to conventional pharmacological methods. The company has developed the ExaStim, a non-invasive neuromodulation system designated as an FDA Breakthrough Device, aimed at treating spinal cord injuries. Additionally, Niche Biomedical is working on a gastrointestinal therapeutic device designed to alleviate postoperative ileus and restore gastrointestinal motility. This device leverages bioelectronic medicine to address diseases and injuries that are resistant to pharmaceutical therapies. The firm is also capable of creating miniaturized implantable devices with advanced functionalities, allowing for diverse electrode configurations to enhance treatment options through neuromodulation.

Zeteo Tech LLC is a defense technology company that specializes in researching, developing, and commercializing innovative solutions for national security and biodefense applications. Founded in 2013 and headquartered in Philadelphia, Pennsylvania, Zeteo Tech focuses on countering unconventional threats through advanced technologies in applied chemical and biological sciences, high-performance distributed sensor systems, and biological mass spectrometry. The company develops a range of products, including instruments for assessing toxins, air and water purification systems, and technologies for remote detection and decontamination. Zeteo Tech serves a diverse clientele, including government agencies and private companies in the United States, leveraging a wide network of affiliates to facilitate prototyping and deployment of its solutions. Its innovations aim to enhance the detection and response capabilities in operational environments, particularly in identifying bio-threats and infectious diseases.

Kodikaz Therapeutic Solutions is a biotechnology company focused on developing targeted cancer therapies that aim to provide durable cures while minimizing side effects associated with traditional treatments. The company has created the Zip-Code™ Technology platform, a pioneering cell-specific delivery system designed for a wide range of gene therapy applications. This innovative platform leverages endogenous human mechanisms to avoid the complications associated with viral delivery methods. By translating previously unknown cell-recognition and genomic integration mechanisms, Kodikaz enables the development of cell-specific gene transfer technologies tailored for various cancers, including pancreatic, myeloma, and colorectal. Through its research and development efforts, the company generates both in-vitro and in-vivo data to support the advancement of curative therapies in oncology.

Serinus Labs, Inc. is a manufacturer of nano-scale silicon gas sensors, established in 2017 and based in Berkeley, California. The company specializes in developing integrated chip-scale gas sensors tailored for various industries, including health and safety, automotive, consumer electronics, and healthcare. Serinus Labs offers custom solutions that address both existing and emerging market needs. In particular, the company focuses on providing ultra-low-power trace gas sensors for Li-ion battery state-of-health monitoring, which enhances battery intelligence in electric vehicles. Through its innovative technology, Serinus Labs aims to meet critical demands across strategic markets.

Founded in 2017, NanoSpy specializes in rapid pathogen detection using proprietary biosensors. These sensors can detect live bacteria at low concentrations within 20 minutes, without the need for time-consuming enrichment processes or laboratory requirements.

KovaDx is a healthcare company focused on improving the lives of individuals suffering from Sickle Cell Disease and other hemolytic anemias. It has developed an affordable point-of-care diagnostic and monitoring tool that leverages Quantitative Phase Imaging and deep learning technology. This innovative system aims to bridge gaps in care for blood diseases by enhancing the understanding of blood health, supporting care management, and predicting outcomes to prevent severe complications. By providing accessible and effective monitoring solutions, KovaDx strives to improve the therapeutic pipeline for rare blood diseases and ultimately enhance the overall prognosis and quality of life for affected patients.

Samay specializes in remote respiratory health management. It develops AI-enabled wearable devices that monitor pulmonary volumes, trapped air, heart rates, breathing sounds, and lung temperature. This enables users to analyze their respiratory data and helps prevent respiratory diseases.

Innsightful develops wearable devices that monitor and detect anxiety and stress symptoms using AI and machine learning. Their solution integrates biometrics for early detection and provides access to therapists for personalized recommendations, empowering users to understand and manage their mental health.

HC Simulation, founded in 2011 and based in Canton, Mississippi, focuses on developing advanced products that utilize the HumMod engine to deliver high-quality simulations of human physiology. The company's offerings enable users to explore physiological interactions that may be difficult to observe in traditional settings. By providing a platform for realistic modeling, HC Simulation supports the ideation, development, and prediction processes for innovative medical devices and pharmaceuticals.

Frugi Biotechnology is a synthetic biology company founded in 2020 and located in Ames, Iowa. The company specializes in the development of modular, paper-based diagnostics aimed at managing viral outbreaks. Frugi Biotechnology's innovative approach includes the creation of custom cell-free extracts, facilitating efficient testing and learning cycles for clients engaged in protein biomanufacturing and discovery. By focusing on simplified and cost-effective methods, Frugi enables organizations to detect pathogens effectively, contributing to improved public health responses during viral outbreaks.

LumenAstra, established in 2020 and headquartered in Longmont, Colorado, specializes in the development of non-invasive, wearable deep-tissue temperature sensors. These devices are designed to accurately measure internal temperatures from external locations, serving diverse applications such as cancer hyperthermia therapy, hypothermia for aortic dissection repair, brain temperature monitoring for newborns, and heat stress monitoring in high-risk environments like military operations or hazardous workplaces. The company's innovative sensor technology enables medical professionals to better protect patients from potential harm caused by extreme temperatures.

SingletO2 Therapeutics, established in 2015 and based in New Providence, New Jersey, focuses on developing innovative treatments for periodontal disease. The company leverages the potent bacteria-killing properties of singlet oxygen to create therapies that can address advanced stages of the disease without the need for surgical intervention.

NeuroTechR3 is a biomedical device and digital health start-up focused on developing affordable rehabilitation technologies aimed at enhancing upper extremity function in individuals affected by brain injuries, such as stroke and cerebral palsy. The company's flagship innovation, R3THATM, leverages machine learning-driven cloud technology and exergames tailored to promote neuroplasticity, incorporating motion tracking, analytics, and real-time biofeedback. Founded in 2020 by four women as a spinout from the New Jersey Institute of Technology and Rutgers School of Health Professions, NeuroTechR3 is committed to transforming the rehabilitation industry into a proactive, patient-centered process. The company operates from locations in Newark, NJ, and Philadelphia, PA, and has established partnerships with rehabilitation hospitals, outpatient centers, and therapists. With its expertise in biomedical engineering and computer science, the team is equipped to adapt swiftly to industry needs, aiming to provide sustainable and accessible rehabilitation solutions for individuals with various impairments. Through the advancement of rehabilitation devices and machine learning technology, NeuroTechR3 seeks to make a significant positive impact on global health outcomes.

Kinetica Labs is a technology company based in Ann Arbor, Michigan, specializing in motion capture technology that transforms video footage into precise posture data. This innovative approach allows for the assessment of ergonomic risks in the workplace without relying on markers, suits, or sensors. In addition to its core technology, Kinetica Labs provides a range of services including insurance consultancy, safety audits, ergonomic assessments, and physical therapy. By integrating advanced sensing and simulation technologies, the company aims to enhance workplace safety and improve overall employee well-being.

QAS.AI focuses on developing and commercializing advanced software that enhances the functionality of image-guided surgical equipment. The company specializes in image analysis and treatment management, creating tools that accurately assess tissue perfusion status and identify vessel occlusion. This software is designed for use during surgical procedures, enabling clinicians to detect areas of inadequate blood flow in the brain and to evaluate the effectiveness of aneurysm correction six months post-embolization. By providing real-time assistance during endovascular surgeries, QAS.AI aims to improve patient outcomes and support healthcare professionals in delivering precise interventions. The multidisciplinary team at QAS.AI includes specialists in biomedical engineering, neurosurgery, and pathology, ensuring a comprehensive approach to surgical technology.

Cordance Medical is a medical device company focused on innovative therapies for central nervous system (CNS) conditions, including primary and metastatic cancers, Alzheimer's disease, and Parkinson's disease. The company has developed a non-invasive ultrasound system specifically designed to open the blood-brain barrier. This low-power ultrasound technology allows for precise and reversible openings of the blood-brain barrier, facilitating targeted delivery of systemically administered medications to specific brain regions. By enhancing access to the brain for therapeutic agents, Cordance Medical aims to create new diagnostic and treatment options for patients suffering from various CNS pathologies.

LiteraSeed is a digital health company that has created a clinically validated platform aimed at enhancing communication between patients and healthcare providers. This platform is specifically designed to assist low health literate patient populations, which includes individuals who may face language barriers or have difficulty articulating their health concerns. By facilitating accurate and remote self-reporting of symptoms, LiteraSeed's technology seeks to prevent misdiagnoses, adverse health events, and unnecessary emergency room visits. The company's focus on improving access to care is particularly beneficial for public health providers serving diverse communities, ensuring that disadvantaged patients receive the attention and resources they need for effective healthcare management.

Synaptek is a digital platform designed to enhance concussion management for clinicians and clinical service providers. It offers a user-friendly, HIPAA-compliant mobile application that simplifies the assessment, tracking, and reporting of concussions. By integrating testing, documentation, and analytics into a single platform, Synaptek helps athletic trainers and healthcare professionals save time and improve communication. This comprehensive solution supports athlete health, recovery, and performance, enabling informed clinical decisions and optimizing the overall management of concussions.

Access Airways is a company that specializes in the development of innovative intubation-delivering devices designed to improve the safety and efficiency of intubation procedures. Their flagship product is a minimally invasive articulating intubation stylet that enhances access to difficult airways, thereby aiming to upscale the standard of care during patient intubation. The device features intuitive capabilities that allow clinicians to perform quicker and less harmful procedures, significantly reducing the time required for intubation and minimizing the risk of failed attempts. Its design enables effortless control and articulation of the tip, allowing for enhanced navigation in challenging airway situations, ultimately benefiting both caregivers and patients.

EndoShunt Medical is a Nashville, Tennessee-based company founded in 2022 that specializes in developing medical devices for targeted hemorrhage control in emergency situations. The company has created a device designed to shunt blood past hemorrhaging vessels endovascularly, allowing surgeons to perform definitive repairs while maintaining blood flow. This innovative approach aims to enhance patient outcomes during critical medical emergencies by providing effective hemorrhage management.

NeuroLogic Solutions is a pre-revenue company based in Baltimore, Maryland, founded in 2016. The company specializes in developing smart electroencephalography (EEG) analytic software designed to enhance the diagnosis and treatment of epilepsy. Its platform analyzes EEG data to identify the regions of the brain affected by epilepsy, which aids clinicians in making accurate diagnoses and optimizing treatment plans. By focusing on neuroimaging analytics, NeuroLogic Solutions aims to improve patient outcomes, potentially leading to seizure freedom for individuals with epilepsy.

PolyLux is an advanced materials company founded in 2016 and headquartered in Akron, Ohio. It specializes in the development of innovative light-switchable adhesive platforms, including a unique non-stick bandage designed to accelerate wound healing. The bandage utilizes a photo-responsive adhesive that adheres more effectively than traditional options while allowing for easy removal upon demand. This technology facilitates hassle-free dressing changes for medical professionals, enhancing the overall efficiency of wound care.

SpheroFill is a drug delivery platform that specializes in creating innovative injectable tissue fillers, specifically designed to address age-related atrophy in the larynx. Utilizing a unique combination of solid, hollow, and porous-wall hollow glass microspheres along with biocompatible and bioactive matrices, SpheroFill enhances drug delivery for healthcare professionals. Its technology enables improved patient compliance by reducing dosing frequency and allows for oral formulations that current technologies cannot achieve. By focusing on the protection, delivery, and controlled release of active pharmaceutical ingredients, SpheroFill represents a significant advancement in the field of drug administration.

Alva Health is a company specializing in the development of healthcare wearables designed for remote stroke monitoring. Its patented devices operate continuously to detect stroke signatures, specifically targeting the early detection of hemiparesis, which is paralysis affecting one side of the body. These wearables are aimed at older individuals at high risk of stroke, enabling them to prevent disability and maintain independence while providing reassurance to their families. By connecting users with emergency services, Alva Health seeks to transform stroke treatment and advance the creation and validation of innovative neurotechnologies.

Notus Labs develops wearable devices that enable remote and non-invasive monitoring of health and performance. Their technology provides users, including both individuals and healthcare professionals, with a comprehensive and continuous overview of vital signs. This information is crucial for optimizing triaging in situations of sudden physiological deterioration. The devices aim to reduce the risk of overexertion injuries and heat-related illnesses, facilitating safer physical activity. Additionally, the products offer training suggestions to help users maximize their physical performance growth while ensuring their well-being.

Dasion is a machine learning software company focused on enhancing healthcare through advanced technologies. It specializes in applying geometric unified machine learning and artificial intelligence to medical diagnostics, including EEG and x-ray technologies. By developing innovative solutions, Dasion aims to improve the quality of medical diagnosis, enabling healthcare providers to utilize effective machine learning tools in their practices. The company is committed to advancing the influence of these technologies in the medical field, facilitating better healthcare outcomes.

The Natural Nipple specializes in the development of innovative feeding bottles that aim to enhance the breastfeeding experience for both mothers and babies. Their products are designed to closely mimic the shape and flow rate of the natural breast, thereby minimizing nipple confusion and facilitating a smooth transition between bottle feeding and breastfeeding. By prioritizing a biotechnological approach, The Natural Nipple supports neurological development and promotes a healthy microbiome, which is essential for the long-term health of infants. Their focus on improving mother-baby bonding and overall health positions them as a significant player in the maternal and infant wellness market.

IngateyGen is an agricultural biotechnology company focused on developing hypoallergenic and allergen-reduced peanuts and allergen-free peanut butter. Using proprietary technologies in genomics, proteomics, plant tissue culture, and plant propagation, the company aims to create peanut varieties and consumer products that reduce allergens and improve safety for individuals with peanut sensitivities, while pursuing scalable agricultural solutions for the food industry.

Precision Theranostics is a biotechnology company established in 2019 and headquartered in Baltimore, Maryland. The company focuses on developing prognosis-based intervention strategies aimed at the early detection and treatment of fatal diseases. Its innovative platform estimates disease progression for respiratory diseases and age-related disorders, facilitating the creation of novel diagnostics, therapeutics, and prognosis-based therapies. By enabling healthcare professionals to provide timely diagnoses and interventions, Precision Theranostics seeks to enhance patient survival rates and prevent the development of chronic and life-threatening conditions.

CellDrop Biosciences is a biotechnology company founded in 2017 and based in Laramie, Wyoming. It specializes in hydrogel-based technologies that facilitate point-of-care diagnostics and targeted biomaterial delivery. The company aims to enhance the healing process for equine musculoskeletal injuries, enabling more efficient recovery and minimizing the risk of re-injury. By leveraging its innovative hydrogel platforms, CellDrop Biosciences provides precise control over chemical and biological systems, ultimately benefiting both patients and the broader medical community.

Radiosight is a company founded in 2020 and headquartered in Hoboken, New Jersey, specializing in ultra-wide imaging technology aimed at improving the diagnosis of skin cancer and informing surgical decisions. The company's innovative technology enhances image resolutions through a proprietary technique and includes a handheld 3D imaging device that reveals the underlying shape and profile of suspicious tissue. This capability allows dermatologists to visualize the margins of lesions prior to biopsy, thereby increasing the accuracy of skin lesion excisions.

Oculogenex is a biopharmaceutical company founded in 2020 and based in La Habra, California. It specializes in the development of gene therapies aimed at treating retinal disorders. The company’s innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced cell death, a condition linked to macular degeneration. By focusing on these therapies, Oculogenex seeks to enable researchers to enhance the detection and treatment of retinal-related disorders, contributing significantly to advancements in this critical area of medical research.