National Science Foundation

Eascra Biotech specializes in developing DNA-inspired, nanoparticle-based delivery systems for targeted therapeutic treatment. Their platform, based on Janus base nanomaterials, encapsulates and stabilizes various therapeutic agents like mRNA, siRNA, proteins, and gene-editing tools, enabling precise delivery to hard-to-reach tissues such as cartilage, kidneys, and solid tumors. This approach enhances therapeutic efficacy, reduces systemic exposure, and preserves bioactivity, offering a low-cost, scalable alternative to existing treatments for chronic conditions.

Auxilium Health is creating low-cost, smart biomaterials for difficult-to-heal wounds.

PediaMetrix is a pediatric health technology company that develops AI-powered cranial measurement and monitoring tools to detect and manage head shape abnormalities in newborns. Its SoftSpot platform provides quantitative cranial measurements via a smartphone app, enabling at-home and in-office use, and offers data-driven guidance and repositioning instructions for parents. The system also gives pediatricians access to simplified analysis and data from the app to support clinical decisions, and is supported by FDA-cleared digital tools for pediatric head assessment. Founded in 2018, the company is based in Rockville, Maryland, and leverages computer vision and artificial intelligence to lower healthcare costs and improve outcomes in pediatric head care.

Amphix Bio specializes in the development of therapeutic materials aimed at advancing regenerative medicine. The company focuses on creating nanofiber materials that replicate the structure and dynamic properties of human tissues. By integrating biological signals into these materials, Amphix Bio effectively guides cells to initiate regenerative processes. This innovative approach enables the development of therapies for repairing various tissues, including bone, cartilage, muscle, cardiovascular tissues, and nervous system components such as the brain and spinal cord. With expertise in materials science, stem cell biology, biomolecular design, engineering, medical physics, and informatics, Amphix Bio seeks to translate its promising preclinical and clinical trial results into viable treatment options.

Eradivir is a biotechnology company based in West Lafayette, Indiana. Founded in 2020, it focuses on developing a non-immunological targeting agent to combat the virus causing COVID-19.

The Wake Forest Institute for Regenerative Medicine (WFIRM) is a leader in translating scientific discovery into clinical therapies. Physicians and scientists at WFIRM were the first in the world to engineer laboratory-grown organs that were successfully implanted into humans. Today, this interdisciplinary team is working to engineer more than 30 different replacement tissues and organs and to develop healing cell therapies-all with the goal to cure, rather than merely treat, disease.

LiteraSeed is a digital health company that has created a clinically validated platform aimed at enhancing communication between patients and healthcare providers. This platform is specifically designed to assist low health literate patient populations, which includes individuals who may face language barriers or have difficulty articulating their health concerns. By facilitating accurate and remote self-reporting of symptoms, LiteraSeed's technology seeks to prevent misdiagnoses, adverse health events, and unnecessary emergency room visits. The company's focus on improving access to care is particularly beneficial for public health providers serving diverse communities, ensuring that disadvantaged patients receive the attention and resources they need for effective healthcare management.

Nanopath is a molecular diagnostics company that develops innovative platforms for rapid disease diagnosis. Its technology enables point-of-care testing, eliminating the need for nucleic acid amplification and supporting multiplexed detection. This allows patients and healthcare providers to access accurate diagnostic results within standard office visits, improving healthcare outcomes.

The Wistar Institute is a leading independent biomedical research institution dedicated to advancing medical knowledge through innovative research and training. Established as the first of its kind in the United States, it has grown from an anatomical teaching museum into a prominent center for basic biomedical research. Designated as a National Cancer Institute Cancer Center in 1972, The Wistar Institute focuses on critical areas such as cancer, immunology, and infectious diseases. Its groundbreaking discoveries have contributed to the development of vaccines for diseases like rabies, rubella, and rotavirus, as well as the identification of genes related to breast, lung, and prostate cancer. The Institute promotes a collaborative research environment aimed at addressing some of the most pressing challenges in the biomedical field.

The University of Louisville is a public research university offering a range of undergraduate and graduate programs across various disciplines. It is committed to advancing knowledge through research in fields such as health, engineering, and the humanities. The university actively collaborates with community partners to enhance its academic and research initiatives, thereby contributing to the education, healthcare, and research sectors. Additionally, the University of Louisville School of Dentistry operates as a specialized institute within the university, focusing on dental education and practice.

The University of California San Diego (UC San Diego) is a public research university renowned for its diverse undergraduate and graduate programs across multiple disciplines. It emphasizes research, community engagement, and interdisciplinary collaboration, making it a hub for innovation and education. The university houses the School of Medicine, which prepares students for careers in healthcare by equipping them with the necessary knowledge and skills to become dedicated medical professionals. Additionally, UC San Diego fosters a multidisciplinary approach to complex systems through its human-centered design thinking labs, collaborating with various industrial partners in fields such as automation and healthcare. It actively supports student involvement in leadership and offers resources for studying abroad, enhancing the overall educational experience.

MelliCell is a biotechnology company focused on addressing chronic diseases through innovative tissue engineering technology that targets fat cells. The company’s platform enables the conversion of human stem cells into mature fat cells, facilitating their accelerated growth to sizes that surpass conventional limits. This technology aims to shrink fat cells and improve metabolic health, making it applicable for treating conditions such as obesity, diabetes, aging, oncology, and inflammation. MelliCell’s experienced team is developing oral small molecules that not only decrease fat mass but also reverse disease hallmarks while preserving lean mass. The efficacy of MelliCell’s technology has been recognized through various awards and partnerships with leading biopharmaceutical firms, highlighting its potential to enhance health outcomes and quality of life for individuals worldwide.

The Wake Forest Institute for Regenerative Medicine (WFIRM) is a leader in translating scientific discovery into clinical therapies. Physicians and scientists at WFIRM were the first in the world to engineer laboratory-grown organs that were successfully implanted into humans. Today, this interdisciplinary team is working to engineer more than 30 different replacement tissues and organs and to develop healing cell therapies-all with the goal to cure, rather than merely treat, disease.

New Jersey Institute of Technology (NJIT) is a research-focused university offering over 70 undergraduate and 15 graduate programs in technology, engineering, biological sciences, computer sciences, and related fields. NJIT is renowned for its state-of-the-art campus, highly qualified faculty, and pioneering research collaborations with local industries. The university's competitive admission process ensures high academic standards, with many students receiving financial aid.

Lapovations is a healthcare company founded in 2016 and headquartered in Fayetteville, Arkansas. It specializes in the development and manufacturing of innovative medical devices specifically designed for laparoscopic surgery. The company aims to redefine laparoscopy by creating products that minimize invasiveness, simplify surgical procedures, and enhance patient outcomes. By focusing on improving the safety and efficacy of surgical practices, Lapovations supports medical professionals in delivering high-quality care.

Founded in 1839, the University of Missouri is a comprehensive public university located in Columbia, Missouri. It offers over 280 degree programs across various fields, including medicine and law. With around 30,000 students from diverse backgrounds, Mizzou is known for its competitive admissions process considering factors such as GPA, SAT/ACT scores, and extracurricular involvement. The university provides academic merit scholarships and federal aid to support students financially.

CerFlux develops advanced cancer modeling technology to enhance understanding and treatment of cancer. Its platform uses innovative ex vivo models to evaluate therapeutic efficacy on patient tumor tissue, enabling oncology professionals to improve patient outcomes through tailored therapy approaches.

Remedium Bio is a Boston-based gene therapy company dedicated to developing curative treatments for a variety of debilitating conditions. The company employs a unique approach that combines established technologies in innovative ways to address well-defined disease mechanisms. By modularly applying these proven technologies, Remedium Bio focuses on creating localized and targeted therapies centered on clinically validated molecules and pathways. Its pipeline includes leading gene therapy candidates in multiple fields, such as rheumatology, endocrinology, and neurology, aimed at providing effective treatments for a range of immune, age-related, and metabolic disorders.

Quantivly, Inc., established in 2019 and headquartered in Somerville, Massachusetts, specializes in developing artificial intelligence-based solutions tailored for the field of radiology. The company focuses on enhancing data liquidity and providing analytical tools that enable radiology providers to make informed decisions, thereby increasing access to medical imaging services. Quantivly's platform is designed to manage and analyze MRI imaging workflows by cleaning and harmonizing scanner data, resulting in a vendor-neutral and comprehensive source of operational knowledge. This innovative approach supports radiology departments and imaging centers in utilizing data analytics to improve decision-making, facilitate new research initiatives, and enhance the overall patient experience in healthcare.

Case Western Reserve University (CWRU) is a private research university located in Cleveland's University Circle. Established in 1843, it comprises various schools including Medicine, Law, Engineering, Arts and Sciences, Nursing, Social Sciences, Dental Medicine, Management, and Mandel School of Applied Social Sciences. CWRU is renowned for its biomedical discoveries, medical education, and top-ranked programs such as international law, health law, and intellectual property law. It offers practical experiences like real-client work and full-time practice experiences to students across various disciplines. The university is accredited by several professional associations and holds membership in the Association of American Universities.

University of Minnesota provides baccalaureate, master’s, and doctoral degrees in medicine, business, law, liberal arts, science, engineering, and architecture fields. They also provide education services to communities through science-based knowledge and training.

GENASSIST is a genetics company that provides assisted reproductive technology genetic consultation and testing services.

MALCOVA develops medical imaging devices focused on early detection and diagnosis of breast cancer in women with dense breasts. It leverages proprietary Narrow-Beam Computed Tomography technology and AI-based software to deliver safe, rapid, high-quality imaging.

Lilu develops innovative, tech-enabled devices for new mothers. Its flagship product is a massage bra that mimics a baby's natural motions during breastfeeding, enhancing milk output and reducing associated discomfort. The company aims to empower women by improving lactation outcomes and managing breast milk supply efficiently.

The University of Louisville is a public research university offering a range of undergraduate and graduate programs across various disciplines. It is committed to advancing knowledge through research in fields such as health, engineering, and the humanities. The university actively collaborates with community partners to enhance its academic and research initiatives, thereby contributing to the education, healthcare, and research sectors. Additionally, the University of Louisville School of Dentistry operates as a specialized institute within the university, focusing on dental education and practice.

Metfora develops an innovative blood test utilizing artificial intelligence to identify patterns in metabolites. This enables early detection of chronic lung disorders, heart diseases, and cancers, enhancing treatment outcomes by facilitating timely diagnoses.

ReSuture, founded in 2019, specializes in high-fidelity physical simulations for surgical training, particularly in open vascular procedures. The company develops innovative surgical instruments that address challenges in contemporary medical simulation. These instruments provide physical stimulation, allowing users to acquire vascular surgical skills in a controlled environment. By enabling medical practitioners to replicate the mechanical properties of human vascular tissue, ReSuture enhances the training experience for future surgeons. This approach not only improves psychomotor skills but also reduces training time, ultimately aiming to enhance patient outcomes and minimize surgical complications.

PneumoNIX Medical is focused on creating innovative gel-based technologies aimed at minimizing complications that can arise from percutaneous procedures, particularly soft tissue biopsies. The company's primary objective is to address and reduce the risk of collapsed lung complications during CT-guided lung biopsies. By developing these specialized medical devices, PneumoNIX Medical seeks to enhance patient safety and improve outcomes in interventional procedures.

Vivifi Medical develops a laparoscopic device that enables quick connection of two blood vessels. Headquartered in Houston, Texas.

The University of Louisville is a public research university offering a range of undergraduate and graduate programs across various disciplines. It is committed to advancing knowledge through research in fields such as health, engineering, and the humanities. The university actively collaborates with community partners to enhance its academic and research initiatives, thereby contributing to the education, healthcare, and research sectors. Additionally, the University of Louisville School of Dentistry operates as a specialized institute within the university, focusing on dental education and practice.

Atom Bioworks develops a DNA-antibody mimic platform for early detection and treatment of infectious diseases. Its technology combines computational biology, quantum chemistry, software, and machine learning to create pattern-recognition constructs.

CPR Therapeutics is a medical device company focused on developing an advanced automated cardiopulmonary resuscitation (CPR) system. The company's innovative technology integrates multiple technological advancements into a single system designed for easy application under emergency conditions. This multimodal CPR system enhances blood flow and the efficacy of electrical countershock, capabilities that are beyond human performance. By combining chest compressions with artificial ventilation, the system aims to preserve brain function and restore spontaneous circulation and breathing in cardiac arrest patients, thereby improving survival rates significantly.

Bespoke Biotherapeutics provides an effective natural immune response and overcomes the limitations of currently approved immunotherapies against cancer by inventing novel, customised living drugs called engineered B-cell therapeutics. They offer customised B-cell sourcing, isolation, activation, culture expansion, and non-viral genetic engineering methodologies uniquely suited to optimise commercial B-cell products for infusion.

AngioInsight develops an AI-powered diagnostic tool to enhance cardiovascular disease detection and management. Its platform provides real-time, image-based assessments of anatomical and functional conditions during coronary angiograms, improving patient care efficiency.

Scopi Medical is a mission-driven company focused on advancing medical optical imaging technology for clinics. By developing a sophisticated hardware platform complemented by state-of-the-art artificial intelligence and machine learning software, Scopi Medical aims to enhance the accuracy of point-of-care diagnostics. Their innovative imaging devices enable practitioners to diagnose and monitor chronic nasal conditions, such as rhinosinusitis, with greater precision and at an earlier stage than traditional methods allow. Additionally, their technology facilitates remote collaboration between healthcare providers and specialists, ensuring that areas of concern can be visualized and treated effectively, ultimately improving patient outcomes.

Tiny Cargo specializes in the isolation and application of exosomes derived from bovine milk. Their technology enables industrial-scale production of these exosomes for various purposes, including pharmaceutical drug delivery, skin repair treatments, and nutritional applications.

Claria Medical specializes in developing innovative, minimally invasive surgical tools aimed at enhancing women's healthcare procedures. Their primary focus is improving hysterectomy and myomectomy surgeries by reducing tissue spread risk during laparoscopic procedures. Claria has received notable recognitions such as the 'Safer Technologies Designation' from the FDA and grants from the National Science Foundation and National Institute of Health.

BrilliantMD is a company specializing in claims management services aimed at the healthcare sector. It develops advanced software designed to address issues related to claims denials. Utilizing artificial intelligence, machine learning, blockchain technology, and advanced analytics, BrilliantMD's software enhances transparency in healthcare data and the claims process. This innovative approach enables healthcare providers to improve revenue outcomes and make informed, data-driven decisions. By transforming the claims management landscape, BrilliantMD aims to streamline operations and enhance efficiency within the healthcare industry.

Oculogenex is a biopharmaceutical company founded in 2020 and based in La Habra, California. It specializes in the development of gene therapies aimed at treating retinal disorders. The company’s innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced cell death, a condition linked to macular degeneration. By focusing on these therapies, Oculogenex seeks to enable researchers to enhance the detection and treatment of retinal-related disorders, contributing significantly to advancements in this critical area of medical research.

Jelikalite develops medical equipment for children with autism spectrum disorders, focusing on non-invasive approaches to support brain health. The company has created a therapeutic wearable device that combines near-infrared light, sensors, and a machine-learning personalization system to deliver non-invasive brain stimulation. Designed for home-based use without a therapist's physical presence, the device seeks to improve communication, responsiveness, and social interaction in children with autism.

Founded in 2018 and based in Baltimore, Maryland, Relavo develops a medical device aimed at preventing infection in peritoneal dialysis. Its flagship product, PeritoneX, is an inline connection device designed to disinfect dialysis tubes at all system connection points, making home dialysis safer and more accessible for kidney failure patients.

Qualia Oto is a biomedical device company based in Dallas, Texas, founded in 2017. The company specializes in advanced cochlear implant technology, utilizing innovative shape-changing polymers and matrix-addressed electrode arrays to create high-quality devices tailored to individual medical and personal needs. Qualia Oto's technology aims to enhance auditory nerve stimulation through higher channel count cochlear implants and auditory brainstem implants, with future plans to incorporate machine learning-based stimulation for more precise outcomes.

Oxalo Therapeutics develops therapies to treat rare kidney diseases and prevent recurrent oxalate-related stones, focusing on primary hyperoxaluria and other oxalate pathologies. It leverages microbiome science, translational research, and early-stage technology to create a gut-derived therapy that safely removes oxalate from the body, reducing stone recurrence and related renal complications.

Creative BioTherapeutics is a biotechnology company dedicated to developing innovative therapies targeting the root causes of cancer affecting immune evasion and drug resistance. Its focus is on recurrent and drug-resistant cancers, aiming to provide effective treatments for adult and childhood cancers.

Simmbion develops a revolutionary system that manufactures therapies within the human body, acting as a 'living pharmacy'. This innovative approach aims to overcome challenges associated with traditional drug delivery methods such as complex manufacturing processes, repeated injections, and high costs. By creating adaptable, reversible cell therapies resistant to supply chain disruptions, Simmbion strives to provide affordable and equitable healthcare solutions globally.

Cryptyx Bioscience is a biopharmaceutical company focused on discovering new therapeutic natural products from bacteria without the use of genetics or cloning. Their innovative platform aims to activate silent biosynthetic gene clusters within bacteria, allowing them to unlock the full potential of culturable microbes. By employing a bioactivity-first approach, Cryptyx seeks to rapidly identify new antibiotics and antiviral drugs, addressing critical needs in combating infectious diseases prioritized by health organizations. The company's technology is designed to provide a broad range of medical services and therapeutic applications, ultimately enhancing treatment options for patients.

Iaso Therapeutics is a therapeutics company established in 2018 and located in East Lansing, Michigan. The company specializes in the development of vaccines aimed at improving human health and addressing infectious diseases. Its platform is designed to create vaccines targeting various deadly infections, including smallpox, yellow fever, and tetanus. By focusing on innovative vaccine technologies, Iaso Therapeutics seeks to equip healthcare professionals with effective tools to combat diseases and enhance overall public health.

Ai-Ris offers automated retinal examinations for primary care. Their retinal imaging system allows general practitioners to screen for diabetic retinopathy without the presence of a specialist. This system consists of a portable headset that uses machine learning algorithms to classify images of the retina of patients without dilating their pupils.

Hypersound Medical is focused on developing non-invasive neuromodulatory devices that utilize neurostimulation techniques to address chronic pain conditions. The company's products employ microwave energy to stimulate nerve cells, offering pain relief for various ailments, including arthritis, back pain, and neuropathic pain. By enhancing pain management, Hypersound Medical aims to improve patient function and reduce reliance on pain medication. Their approach encompasses various stimulation methods, such as peripheral nerve stimulation and spinal cord stimulation, positioning the company as a key player in the field of pain relief technology.

Lura Health develops a non-invasive continuous health monitoring platform that uses saliva as a diagnostic fluid. The company integrates micro-sensors into orthodontic devices such as retainers, aligners, and brackets to continuously measure saliva analytes and securely transmit data to a smartphone app, enabling users to monitor oral health metrics and potentially support broader chronic disease management. Target markets include heart disease, chronic kidney disease, diabetes, and tooth decay. Founded in 2017, the company is based in Cambridge, Massachusetts.

Visicell Medical develops innovative stem cell tracking tools designed to enhance the safety and efficacy of regenerative therapies. Their biodegradable tools enable real-time tracking of injected stem cells in both clinical and pre-clinical settings, aiming to improve treatment outcomes for patients with incurable diseases.

Amphix Bio specializes in the development of therapeutic materials aimed at advancing regenerative medicine. The company focuses on creating nanofiber materials that replicate the structure and dynamic properties of human tissues. By integrating biological signals into these materials, Amphix Bio effectively guides cells to initiate regenerative processes. This innovative approach enables the development of therapies for repairing various tissues, including bone, cartilage, muscle, cardiovascular tissues, and nervous system components such as the brain and spinal cord. With expertise in materials science, stem cell biology, biomolecular design, engineering, medical physics, and informatics, Amphix Bio seeks to translate its promising preclinical and clinical trial results into viable treatment options.

UCHU Biosensors develops a platform of tooth mounted sensors to effortlessly track health through saliva.

Levisonics manufactures blood coagulation instruments for non-contact analysis of blood coagulation and fluid quality control. Its technology enables risk assessments for bleeding and thrombosis, and real-time monitoring of liquid goods' quality during production.

Cytocybernetics specializes in cellular electrophysiology. They offer a user-friendly plug-and-play dynamic clamp system called Cybercyte and provide comprehensive contract research organization (CRO) services, including FDA-mandated drug safety screening, custom electrophysiology studies, modeling, and analysis.

InvVax develops innovative vaccines using its proprietary platform. Its flagship product is a universal influenza vaccine designed to provide broad, long-lasting protection against all flu strains.

Intelligent Medicine is a company that specializes in software and simulation services focused on the medical, artificial intelligence, and virtual reality sectors. The company has developed a simulation platform aimed at reducing the probability of infectious spread and user congestion in various environments. This platform enables architects and facility stakeholders to identify risks, optimize building designs, and redesign protocols to enhance safety outcomes. By testing multiple design scenarios and behaviors, Intelligent Medicine provides quick feedback that assists in planning effective safety policies and design actions, ultimately improving facility infrastructure and user experiences.

Taurus Diagnostics is a health-tech company focused on enhancing the diagnostic process for men suspected of having prostate cancer. The company leverages data-centric artificial intelligence to improve the accuracy of magnetic resonance imaging (MRI), minimizing the need for unnecessary biopsies. Its advanced AI algorithm has been trained on a vast array of patient data to reliably identify lesions indicative of prostate cancer. This technology empowers physicians to effectively pinpoint patients who are most in need of a biopsy and provides clear visualizations of lesion locations, thereby streamlining the diagnostic process and improving patient outcomes.

Nostopharma specializes in treating pathologic bone growth to prevent rare bone diseases. Their nanoparticle drug delivery system aids patients in forming new bone following surgeries, burns, injuries, and other traumas, enabling healthcare providers to enhance clinical outcomes.

Juggernaut Life Sciences specializes in developing innovative medical technologies. They focus on four key areas: medicine, image guidance, robotics, and artificial intelligence. Their primary business is designing and developing medical devices and platforms that can perform routine procedures with minimal human intervention, aiming to enhance safety and reduce costs for their clients.

Founded in 2018, Aurie is a medical device company specializing in reusable urinary catheterization systems. Its flagship product is a portable, battery-operated case that washes, dries, and stores catheters, enabling individuals with mobility or neurological conditions to perform safe and independent urinary care.

SafeBVM develops a medical device accessory designed to prevent hyperventilation during manual resuscitation. Its product, Sotair, uses a flow-blocking valve mechanism to regulate airflow and reduce complications such as stomach insufflation and respiratory distress.

PediaMetrix is a pediatric health technology company that develops AI-powered cranial measurement and monitoring tools to detect and manage head shape abnormalities in newborns. Its SoftSpot platform provides quantitative cranial measurements via a smartphone app, enabling at-home and in-office use, and offers data-driven guidance and repositioning instructions for parents. The system also gives pediatricians access to simplified analysis and data from the app to support clinical decisions, and is supported by FDA-cleared digital tools for pediatric head assessment. Founded in 2018, the company is based in Rockville, Maryland, and leverages computer vision and artificial intelligence to lower healthcare costs and improve outcomes in pediatric head care.

Alienbyte specializes in the provision of medical images and their corresponding labels, essential for advanced analysis of human and animal anatomy as well as for training artificial intelligence algorithms. The company has developed a web application that facilitates the labeling of three-dimensional tomographic images. This application includes a user-friendly web interface and tools for creating and managing labels, enhanced by artificial intelligence-assisted labeling techniques. By employing algorithmic methods, Alienbyte aims to streamline the labeling process, thereby increasing the utility of medical images for researchers, healthcare professionals, and patients.

Reselute specializes in designing, developing, and validating innovative medical devices. Their primary focus is on creating orthopaedic spacers that enhance the treatment of implant-related infections, enabling healthcare professionals to accelerate recovery and improve patient care.

Oncurie is a biotechnology company focused on developing targeted radionuclide therapy aimed at treating metastatic cancer. Utilizing innovative molecular radionuclide technology, Oncurie seeks to deliver radionuclides selectively to metastatic tissues, thereby enhancing treatment efficacy and improving patient outcomes. The company's goal is to provide healthcare providers with advanced therapeutic options that may lead to a cure for various forms of metastatic cancer, including breast cancer. Through its research and development efforts, Oncurie is committed to transforming cancer treatment and addressing unmet medical needs in oncology.

Optical Waters specializes in innovative disinfection solutions that enhance the safety and cleanliness of products for various industries. The company has developed patent-pending optical fibers that emit germicidal ultraviolet light along their entire length, effectively inactivating microorganisms in their vicinity. These advanced fibers are designed to be stable in water, allowing for integration into complex geometries and narrow-diameter channels, such as piping and tubing. By providing these unique disinfection systems, Optical Waters enables businesses to ensure that their products meet high safety standards for end users.

PZA Innovation is a biotechnology company focused on improving tuberculosis treatment through the development of a reliable pyrazinamide susceptibility testing method. By employing reverse engineering techniques, the company identifies the specific conditions under which pyrazinamide demonstrates effectiveness in vitro, targeting the living environment of mycobacterium tuberculosis within the host. This innovative approach aims to enable healthcare professionals to deliver next-generation pyrazinamide therapies, ultimately shortening the duration of tuberculosis treatment and enhancing patient outcomes.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative gene therapy treatments for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes advanced oral lipid nanoparticle technology to deliver mRNA and plasmid DNA directly to intestinal stem cells. This approach aims to address the root causes of gastrointestinal diseases, including Familial Adenomatous Polyposis (FAP), a hereditary condition that can lead to colorectal cancer and often necessitates invasive surgical interventions. DNALite's therapies seek to transform protein biologics into oral drugs, allowing for more effective and less invasive treatment options.

BiRed Imaging specializes in advanced medical imaging technology focused on the early detection of breast cancer. The company has developed an innovative platform that combines infrared imaging with a proprietary computerized detection algorithm, enabling accurate identification of the size and location of tumors, particularly in patients with dense breast tissue. This technology serves as an effective adjunct to traditional breast cancer screening methods, helping clinicians to recognize high-risk patients at an early stage. By enhancing the accuracy and cost-effectiveness of breast cancer detection, BiRed Imaging aims to improve patient outcomes in oncology.

IntuiTap Medical is a medical device company that develops a handheld system to guide spinal puncture procedures. The device aims to eliminate guesswork, frustration, and pain associated with spinal taps by integrating spine imaging, needle guidance, and analytics to enable accurate needle placements for lumbar punctures, spinal anesthesia, and epidurals. The system seeks to improve procedure efficiency and reduce costs while enhancing clinician confidence and patient experience. The company was founded in 2016 and is headquartered in Houston, Texas.

Nanopath is a molecular diagnostics company that develops innovative platforms for rapid disease diagnosis. Its technology enables point-of-care testing, eliminating the need for nucleic acid amplification and supporting multiplexed detection. This allows patients and healthcare providers to access accurate diagnostic results within standard office visits, improving healthcare outcomes.

Huxley Medical is a private company focused on developing medical devices. It collaborates with leading clinicians and scientists to create innovative devices and algorithms, enhancing users' access to diverse diagnostic tools and treatment options.

MBF Therapeutics, Inc. is a veterinary oncology company based in Ambler, Pennsylvania, focused on developing and commercializing innovative therapies for cancer treatment in dogs and cats. The company specializes in targeted immunotherapies and small molecule drugs that effectively disrupt tumor cell metabolism while preserving healthy cells and organs. Its product portfolio includes MBFT-101, a combination therapy for sarcomas and lymphoma, featuring a proprietary polyamine transport inhibitor and a potent inhibitor of ornithine decarboxylase, as well as MBFT-102, an immunotherapy based on the tumor suppressor/cytokine mda-7/IL24, which has shown promise in human cancers. Additionally, MBF Therapeutics employs a proprietary DNA vaccine platform and delivery system to develop immunotherapeutic vaccines aimed at enhancing protective immunity against infectious diseases in companion animals and livestock. The company maintains a strategic partnership with the Lankenau Institute for Medical Research to further advance its research and development initiatives.

Vulcan Biologics, established in 2019 and based in Irvine, California, specializes in biotechnology solutions for modulating microbiomes. Its core platform employs bacteriophages, which selectively target and alter specific gut bacteria without affecting the human host, aiming to achieve stable and persistent changes in the microbiome. This approach is primarily focused on treating gluten-related disorders, including gluten sensitivity and celiac disease.

Astek Diagnostics is a healthcare company that develops precision diagnostic technology aimed at improving the diagnosis and treatment of bacterial infections. The company has created a platform that assists physicians in prescribing the correct antibiotics for patients suffering from bacterial sepsis within one hour. Utilizing a single-use cartridge, Astek Diagnostics' device identifies bacterial infections in urine by measuring the oxygen consumption of bacterial species, significantly reducing the turnaround time for results. This innovative approach not only facilitates timely treatment but also helps combat antibiotic resistance through effective susceptibility testing.

Averto Medical specializes in the manufacture of medical devices designed to improve outcomes for patients with gastrointestinal diseases. Their innovative solutions aim to facilitate minimally invasive colorectal tumor removal and other gastrointestinal surgeries, enabling healthcare professionals to provide optimal care.

Akttyva Therapeutics develops targeted therapeutics to address cell barrier dysfunction across multiple indications.

OPOS specializes in opioid treatment for patients, ensuring regulatory compliance. Its platform reduces administrative burden, minimizes prescribing risks, and optimizes patient outcomes by providing clinical decision support.

EchoWear is a company focused on enhancing healthcare access through its innovative smartwatch-based system. This system facilitates meaningful interactions between patients and care teams, promoting the development of actionable digital health services. By prioritizing age-friendly health technologies, EchoWear aims to improve the overall healthcare experience for users, ensuring that they can effectively engage with their health management through digital solutions.

Synvivia, Inc. is a biotechnology company founded in 2016 and based in Berkeley, California. The company specializes in developing synthetic biology products, particularly ON-OFF switches for genetically engineered organisms. These protein switches are regulated by small molecules, allowing for precise control of biological functions within the organisms. Synvivia's innovations enable the creation of engineered organisms that can be utilized in healthcare, specifically for diagnosing diseases and enhancing treatment options. Additionally, the company is focused on generating biosensors to identify and improve enzymatic activities, thereby facilitating more effective disease management.

Nasus Medical specializes in developing innovative, non-invasive drug-delivery devices aimed at improving the treatment of chronic sinusitis. Their flagship product enables patients to self-administer medication rapidly and conveniently, reducing the need for oral medications with systemic side effects, injections by healthcare professionals, or costly surgical procedures. This approach aims to enhance patient comfort, convenience, and outcomes while lowering overall healthcare costs.

Cision Vision is a biotechnology company focused on developing and supplying innovative imaging medical products specifically designed for the examination of lymph nodes. Its advanced imaging devices enable pathologists to visualize, scan, and record lymph nodes in real-time with high contrast, eliminating the need for injections or radiation. By providing pathologists with tools that enhance the accuracy and consistency of pathology grossing, Cision Vision aims to modernize the field and improve the quality of care delivered to patients.

Pragma Health provides digital healthcare services. They permit users to perform different tests for cardiovascular, hematology, infectious diseases, and others in the privacy of their home and provide accurate, immediate results, enabling them to get a convenient, cost-effective, and accurate healthcare testing process.

Aracari Biosciences develops a vascularized micro-organ platform designed to accelerate drug discovery. This platform enables real-time imaging of vessel morphology, allowing for more authentic pre-clinical testing and enhancing decision-making in drug development.

Koda Health develops an AI-driven video-based platform that guides elderly patients through personalized end-of-life conversations, empowering them to make informed healthcare decisions and ensuring their preferences are respected. This reduces inappropriate care and generates valuable data on patient personas while saving costs for healthcare systems.

ColoWrap, LLC is a medical device company based in Durham, North Carolina, established in 2012. The company specializes in developing a non-invasive device designed to enhance the efficiency and comfort of colonoscopy procedures. ColoWrap's innovative device exerts sustained, adjustable pressure on the patient's lower abdomen, effectively preventing looping in the colon. This minimizes the need for manual pressure and reduces the necessity for patient repositioning during the procedure. Constructed from latex-free material similar to that used in high-performance wetsuits, the device aims to facilitate a more comfortable and less invasive experience for patients while allowing medical practitioners to perform colonoscopies more effectively.

Clairways specializes in smart lung monitoring for pharmaceutical clinical trials. Its wearable device captures key respiratory metrics for individuals with asthma, COPD, CF, or other chronic respiratory diseases.

Green Sun Medical, LLC is a medical device company specializing in the design, development, and manufacturing of orthotic braces for the treatment of Adolescent Idiopathic Scoliosis (AIS) and Kyphosis. Founded in 2013 and based in Fort Collins, Colorado, the company is focused on creating innovative solutions to correct spinal deformities. Its flagship product is a dynamic spinal alignment brace that applies continuous corrective pressure to the spine, facilitating effective treatment for conditions such as scoliosis and kyphosis. This technology-enabled brace not only aids in the physical correction of spinal issues but also allows physicians to remotely monitor its performance in real-time, enhancing patient care and recovery outcomes.

Felix Biotechnology, Inc. is a San Francisco-based company founded in 2019 that specializes in developing biotherapeutics to combat microbial challenges in human health. The company focuses on creating treatments for antibiotic-resistant strains of bacteria and fungi, aiming to address the urgent need for effective management of infectious diseases. By accelerating the deployment of novel biotherapeutics, Felix Biotechnology seeks to provide healthcare professionals with precise and effective tools to tackle these pressing health issues.

Biochip Labs is a company based in Cleveland, Ohio, founded in 2019. It specializes in providing laboratory testing services focused on blood disorders, particularly sickle cell disease and thalassemia. The company offers a range of proprietary microfluidic biomarker assays, including tests for blood cell adhesion, red blood cell deformability, whole blood rheology, and endothelialized microfluidics. These assays are designed to evaluate the effectiveness of emerging targeted and curative therapies, allowing clinicians to monitor patients' responses to treatment accurately.

CollaMedix is a company focused on the development of innovative medical devices for soft tissue repair and augmentation, particularly addressing stress urinary incontinence in women. Utilizing proprietary collagen-based materials, CollaMedix offers a bio-inductive scaffold made from pure collagen that provides structural support to human tissue. This advanced collagen fabric is designed to withstand significant loads while promoting rapid cell integration. By facilitating the development of new treatments for female pelvic health, CollaMedix aims to deliver safe and effective solutions for conditions related to urine leakage that occur during activities such as laughing, coughing, sneezing, lifting, and exercise.

Synopic develops advanced imaging technology for minimally invasive medical procedures. Utilizing a single camera implementation, they capture measurable 3D information and high-resolution color images, enhancing visualization and decision-making during surgeries.

Frontier Bio Corporation is a biotechnology company based in Oakland, California, focused on developing and manufacturing advanced bioprinting technologies. Founded in 2018, the company specializes in creating lab-grown human tissues as an ethical alternative to animal studies. Its flagship product, the FLUX-1, is a 3D bioprinter that integrates conventional bioprinting methods with electro-hydrodynamic printing capabilities. This device enables the bioprinting of complex tissues such as skin, cartilage, and bone, and allows for applications in drug toxicity testing, tissue implants, drug screening, disease modeling, and prosthetics. By providing a means to produce human tissues with complete cell survivability, Frontier Bio aims to enhance the healthcare industry's ability to replace animal testing and address the organ transplant waitlist.

Kodikaz Therapeutic Solutions develops a genomic transfer delivery platform for RNA and DNA delivery vectors, aiming to move beyond conventional cancer therapies toward durable cures through targeted gene transfer. Its Zip-Code technology is a cell-specific delivery system derived from an endogenous human mechanism, designed to avoid the challenges of viral delivery and to be applicable across multiple cell types. The company translates cell-recognition and genomic integration mechanisms identified in human cancers into practical therapies, generating both in vitro and in vivo data in oncology to support the development of cell-targeted gene transfer technologies into curative treatments. Applications include cancers such as pancreatic cancer, multiple myeloma, and colorectal cancer, and the platform supports collaborations to help clients develop cell-specific gene transfer approaches.

TRGel is a biotechnology company founded in 2010 and based in Irvine, California, specializing in the development of glucose-based biopolymers that serve as alternatives to calcium alginate for encapsulation purposes. The company's biopolymers are crafted from biocompatible materials and include thermoresponsive hydrogels with adjustable gelation temperatures. This innovative approach allows researchers to effectively use TRGel's biopolymers as vehicles for drug delivery, enhancing the potential for various therapeutic applications.

MileMarker is a real-time assessment software designed for medical training, developed by leaders from the Johns Hopkins University School of Medicine. The platform addresses the evolving needs of residency programs by facilitating competency-based learning while simultaneously reducing training costs and enhancing communication. By offering an accessible solution that works on any mobile device or computer, MileMarker enables residents to log operative cases and conduct self-assessments, which are then reviewed by attending surgeons who provide additional feedback. This process is designed to be efficient, taking less than one minute to complete within existing workflows. The software captures real-time data on resident performance, allowing for ongoing monitoring and comparison against peers, thus promoting accountability and transparency in training. MileMarker not only helps residency programs meet regulatory requirements but also has the potential to increase revenue and decrease training time significantly.

Founded in 2017, NanoSpy specializes in rapid pathogen detection using proprietary biosensors. These sensors can detect live bacteria at low concentrations within 20 minutes, without the need for time-consuming enrichment processes or laboratory requirements.

TheraCea Pharma is a biotechnology company specializing in precision medicine for neurological disorders. Based in Tucson, Arizona, it develops and licenses radiochemistry technology enabling high-efficiency fluorine-18 radiolabeling of biomolecules for clinical and research applications.

KovaDx is a healthcare company focused on improving the lives of individuals suffering from Sickle Cell Disease and other hemolytic anemias. It has developed an affordable point-of-care diagnostic and monitoring tool that leverages Quantitative Phase Imaging and deep learning technology. This innovative system aims to bridge gaps in care for blood diseases by enhancing the understanding of blood health, supporting care management, and predicting outcomes to prevent severe complications. By providing accessible and effective monitoring solutions, KovaDx strives to improve the therapeutic pipeline for rare blood diseases and ultimately enhance the overall prognosis and quality of life for affected patients.