New Enterprise Associates

MBX Biosciences, Inc. is a biotechnology company based in Carmel, Indiana, specializing in the development of therapeutics for rare endocrine disorders. Established in 2018, the company focuses on creating peptides aimed at treating genetic diseases that affect glandular hormones, which play a crucial role in the body’s chemical messaging system. By targeting conditions with inadequate treatment options, MBX Biosciences is dedicated to discovering, developing, and commercializing innovative endocrine therapeutics.

SimpleRose Inc. is a technology company based in Saint Louis, Missouri, that specializes in developing a prescriptive analytics platform aimed at enhancing decision-making processes in complex environments. Founded in 2018, the company's solutions focus on optimizing operations through applications such as scheduling, production planning, and portfolio optimization. By leveraging algorithmic innovations for improved numerical accuracy and speed, SimpleRose enables organizations to tackle intricate operational challenges and make informed decisions in real-time.

Relievant Medsystems, Inc. is a medical device company focused on developing minimally invasive treatments for chronic axial low back pain. The company has created the Intracept procedure, which specifically targets the basivertebral nerve to alleviate chronic vertebrogenic low back pain. By delivering targeted energy into the spine, the Intracept System effectively blocks the transmission of pain signals, providing patients with a low-risk therapeutic option. Founded in 2004, Relievant is headquartered in Minneapolis, Minnesota, with additional operations in Sunnyvale, California.

MBX Biosciences, Inc. is a biotechnology company based in Carmel, Indiana, specializing in the development of therapeutics for rare endocrine disorders. Established in 2018, the company focuses on creating peptides aimed at treating genetic diseases that affect glandular hormones, which play a crucial role in the body’s chemical messaging system. By targeting conditions with inadequate treatment options, MBX Biosciences is dedicated to discovering, developing, and commercializing innovative endocrine therapeutics.

Celcuity Inc. is a clinical-stage biotechnology company based in Minneapolis, Minnesota, focused on advancing cancer treatment through innovative diagnostics. The company's CELsignia diagnostic platform utilizes living tumor cells to uncover specific cellular processes that drive cancer in individual patients. This approach enables the identification of new cancer sub-types that traditional molecular diagnostics may overlook, ultimately expanding therapeutic options. Celcuity is developing the CELsignia HSF test to diagnose two new sub-types of HER2-negative breast cancer and the CELsignia MP test for diagnosing 11 sub-types across various cancers, including breast, lung, colon, ovarian, kidney, and bladder. The company is also advancing its lead therapeutic candidate, gedatolisib, a pan-PI3K and mTOR inhibitor, currently being evaluated in a Phase 3 clinical trial for patients with advanced HR+/HER2- breast cancer.

Collective Health is a prominent health benefits platform that streamlines the management of medical, dental, vision, and pharmacy services for employees and their families. By offering an integrated solution through a cloud-based self-insurance platform, the company simplifies the administration of health plans via a single portal. This platform provides users with clear guidance, live concierge support, and digital tools to facilitate the navigation and management of healthcare services. Collective Health aims to reduce the complexities of delivering health benefits, enhance the member experience, and promote healthier outcomes for both employees and organizations. Headquartered in San Francisco, California, the company also has offices in Chicago, Illinois, and Lehi, Utah.

Relievant Medsystems, Inc. is a medical device company focused on developing minimally invasive treatments for chronic axial low back pain. The company has created the Intracept procedure, which specifically targets the basivertebral nerve to alleviate chronic vertebrogenic low back pain. By delivering targeted energy into the spine, the Intracept System effectively blocks the transmission of pain signals, providing patients with a low-risk therapeutic option. Founded in 2004, Relievant is headquartered in Minneapolis, Minnesota, with additional operations in Sunnyvale, California.

Everactive, Inc., also known as Everactive Insights, Inc., specializes in the development of wireless sensing devices and technologies tailored for Industrial Internet of Things (IoT) applications. The company produces ultra-low-power chips that enable battery-less wireless sensors, facilitating data generation and analytics for various industrial operations. Its innovations include PsiKick integrated circuits, which support programmable processing, power management, and RF communication. Everactive's solutions encompass steam trap monitoring, flare system monitoring, and machine health monitoring, allowing for continuous analysis of industrial assets. Founded in 2012 and headquartered in Santa Clara, California, Everactive also has locations in Charlottesville, Virginia, and Ann Arbor, Michigan. The company’s technology is based on energy harvesting, enabling low-cost and long-lived instrumentation that supports sustainable and scalable IoT applications.

MBX Biosciences, Inc. is a biotechnology company based in Carmel, Indiana, specializing in the development of therapeutics for rare endocrine disorders. Established in 2018, the company focuses on creating peptides aimed at treating genetic diseases that affect glandular hormones, which play a crucial role in the body’s chemical messaging system. By targeting conditions with inadequate treatment options, MBX Biosciences is dedicated to discovering, developing, and commercializing innovative endocrine therapeutics.

CVRx, Inc. is a medical device company based in Minneapolis, Minnesota, that specializes in implantable technology for treating high blood pressure and heart failure. The company develops Barostim, a proprietary neuromodulation therapy that activates the body's natural reflexes to regulate blood pressure and address the progression of heart failure. This therapy is delivered through a long-lasting implant system that is tailored to meet individual patient needs. CVRx also manufactures the Rheos implantable pulse generator and associated components, which facilitate the delivery of activation energy to the carotid arteries. Founded in 2000, CVRx primarily serves patients and healthcare professionals in the United States and several European countries, focusing on minimally invasive solutions for cardiovascular diseases.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Collective Health is a prominent health benefits platform that streamlines the management of medical, dental, vision, and pharmacy services for employees and their families. By offering an integrated solution through a cloud-based self-insurance platform, the company simplifies the administration of health plans via a single portal. This platform provides users with clear guidance, live concierge support, and digital tools to facilitate the navigation and management of healthcare services. Collective Health aims to reduce the complexities of delivering health benefits, enhance the member experience, and promote healthier outcomes for both employees and organizations. Headquartered in San Francisco, California, the company also has offices in Chicago, Illinois, and Lehi, Utah.

CVRx, Inc. is a medical device company based in Minneapolis, Minnesota, that specializes in implantable technology for treating high blood pressure and heart failure. The company develops Barostim, a proprietary neuromodulation therapy that activates the body's natural reflexes to regulate blood pressure and address the progression of heart failure. This therapy is delivered through a long-lasting implant system that is tailored to meet individual patient needs. CVRx also manufactures the Rheos implantable pulse generator and associated components, which facilitate the delivery of activation energy to the carotid arteries. Founded in 2000, CVRx primarily serves patients and healthcare professionals in the United States and several European countries, focusing on minimally invasive solutions for cardiovascular diseases.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Mejuri Inc. is a Canadian company that specializes in the manufacture and sale of fine jewelry, including rings, necklaces, earrings, bracelets, and engagement pieces. Founded in 2015 and headquartered in Toronto, Mejuri operates showrooms in New York, Toronto, and Chicago, while also offering its products through a direct-to-consumer e-commerce platform. This model allows Mejuri to provide quality handcrafted jewelry at accessible prices by eliminating middlemen and maintaining a fast supply chain that introduces new designs weekly. Committed to exceptional craftsmanship and ethical practices, Mejuri aims to empower women to incorporate luxury into their everyday lives. The company serves customers not only in Canada and the United States but also internationally.

Catalytic Inc. operates a cloud-based automation platform designed to streamline data processing tasks for businesses. Founded in 2015 and based in Chicago, Illinois, with an additional office in Naperville, the company provides a solution that enables users to build an intelligent automation layer for processing data, documents, emails, and other systems. The platform allows for the automation of various tasks, including document generation, trigger responses, and data collection, while facilitating integration with existing systems through APIs and SFTP. Catalytic empowers business users to create process-driven solutions tailored to their needs, enhancing efficiency and productivity across organizations. Clients such as Bosch, Dentsu Aegis Network, and UL have leveraged Catalytic's capabilities to improve their operational efficiency, deliver better customer experiences, and increase profitability.

SimpleRose Inc. is a technology company based in Saint Louis, Missouri, that specializes in developing a prescriptive analytics platform aimed at enhancing decision-making processes in complex environments. Founded in 2018, the company's solutions focus on optimizing operations through applications such as scheduling, production planning, and portfolio optimization. By leveraging algorithmic innovations for improved numerical accuracy and speed, SimpleRose enables organizations to tackle intricate operational challenges and make informed decisions in real-time.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Relievant Medsystems, Inc. is a medical device company focused on developing minimally invasive treatments for chronic axial low back pain. The company has created the Intracept procedure, which specifically targets the basivertebral nerve to alleviate chronic vertebrogenic low back pain. By delivering targeted energy into the spine, the Intracept System effectively blocks the transmission of pain signals, providing patients with a low-risk therapeutic option. Founded in 2004, Relievant is headquartered in Minneapolis, Minnesota, with additional operations in Sunnyvale, California.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Collective Health is a prominent health benefits platform that streamlines the management of medical, dental, vision, and pharmacy services for employees and their families. By offering an integrated solution through a cloud-based self-insurance platform, the company simplifies the administration of health plans via a single portal. This platform provides users with clear guidance, live concierge support, and digital tools to facilitate the navigation and management of healthcare services. Collective Health aims to reduce the complexities of delivering health benefits, enhance the member experience, and promote healthier outcomes for both employees and organizations. Headquartered in San Francisco, California, the company also has offices in Chicago, Illinois, and Lehi, Utah.

Everactive, Inc., also known as Everactive Insights, Inc., specializes in the development of wireless sensing devices and technologies tailored for Industrial Internet of Things (IoT) applications. The company produces ultra-low-power chips that enable battery-less wireless sensors, facilitating data generation and analytics for various industrial operations. Its innovations include PsiKick integrated circuits, which support programmable processing, power management, and RF communication. Everactive's solutions encompass steam trap monitoring, flare system monitoring, and machine health monitoring, allowing for continuous analysis of industrial assets. Founded in 2012 and headquartered in Santa Clara, California, Everactive also has locations in Charlottesville, Virginia, and Ann Arbor, Michigan. The company’s technology is based on energy harvesting, enabling low-cost and long-lived instrumentation that supports sustainable and scalable IoT applications.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Noonlight, Inc. is a company that specializes in personal safety through its mobile application, which connects various Internet of Things (IoT) devices to enhance user protection. Founded in 2013 and headquartered in Saint Louis, Missouri, Noonlight's platform provides 24/7 professional monitoring and data-driven emergency response capabilities. The application enables users to create accounts and connect multiple devices, allowing for precise location detection in emergencies. In critical situations, it can alert authorities without necessitating a 911 call or verbal communication. Noonlight's technology is operational across the United States, making it a versatile tool for enhancing personal safety and comfort.

Mighty AI, Inc. operates a Training Data as a Service platform that assists businesses in acquiring the datasets necessary to train and enhance their computer vision and natural language models. The company's platform features a global community of individuals who perform micro tasks, such as labeling objects in images and conducting sentiment analysis on text. By leveraging its proprietary machine learning technology and a comprehensive suite of annotation software, Mighty AI ensures high accuracy and scalability in the data it provides. Founded in 2014 and headquartered in Seattle, Washington, with an additional office in Detroit, Michigan, Mighty AI serves customers worldwide and specializes in delivering training data for companies developing computer vision models, particularly for autonomous vehicles. The company was previously known as Spare5 Inc. and became a subsidiary of Uber Technologies, Inc. in 2019.

Relievant Medsystems, Inc. is a medical device company focused on developing minimally invasive treatments for chronic axial low back pain. The company has created the Intracept procedure, which specifically targets the basivertebral nerve to alleviate chronic vertebrogenic low back pain. By delivering targeted energy into the spine, the Intracept System effectively blocks the transmission of pain signals, providing patients with a low-risk therapeutic option. Founded in 2004, Relievant is headquartered in Minneapolis, Minnesota, with additional operations in Sunnyvale, California.

Fieldglass, Inc. specializes in providing intelligent solutions for managing human capital, focusing on the procurement and management of contingent workers and services. The company offers a unified technology platform that facilitates the hiring process for managers and human resources personnel. Its primary offerings include InSite Contingent, a software-as-a-service platform that automates the entire lifecycle of contingent labor management, InSite Services for ensuring compliance in project-based engagements, and InSite Recruitment for automating direct hiring processes. Additionally, Fieldglass provides professional services such as implementation, training, and support. The company serves a diverse range of industries, including financial services, healthcare, pharmaceuticals, and telecommunications. Founded in 1999 and headquartered in Chicago, Illinois, Fieldglass has technology development offices in Naperville, Illinois, and Mumbai, India.

Catalytic Inc. operates a cloud-based automation platform designed to streamline data processing tasks for businesses. Founded in 2015 and based in Chicago, Illinois, with an additional office in Naperville, the company provides a solution that enables users to build an intelligent automation layer for processing data, documents, emails, and other systems. The platform allows for the automation of various tasks, including document generation, trigger responses, and data collection, while facilitating integration with existing systems through APIs and SFTP. Catalytic empowers business users to create process-driven solutions tailored to their needs, enhancing efficiency and productivity across organizations. Clients such as Bosch, Dentsu Aegis Network, and UL have leveraged Catalytic's capabilities to improve their operational efficiency, deliver better customer experiences, and increase profitability.

Rotation Medical Inc. is a medical device company based in Plymouth, Minnesota, specializing in the development of a minimally invasive rotator cuff implant system designed for the treatment of rotator cuff diseases. The company's primary product is a collagen scaffold that is affixed to the affected rotator cuff tendon, aimed at managing tendon injuries and providing protection for both small and larger rotator cuff tears. Founded in 2009 and initially known as Denali Medical Inc., the company rebranded to Rotation Medical in March 2010. As of December 2017, Rotation Medical operates as a subsidiary of Smith & Nephew plc.

Everactive, Inc., also known as Everactive Insights, Inc., specializes in the development of wireless sensing devices and technologies tailored for Industrial Internet of Things (IoT) applications. The company produces ultra-low-power chips that enable battery-less wireless sensors, facilitating data generation and analytics for various industrial operations. Its innovations include PsiKick integrated circuits, which support programmable processing, power management, and RF communication. Everactive's solutions encompass steam trap monitoring, flare system monitoring, and machine health monitoring, allowing for continuous analysis of industrial assets. Founded in 2012 and headquartered in Santa Clara, California, Everactive also has locations in Charlottesville, Virginia, and Ann Arbor, Michigan. The company’s technology is based on energy harvesting, enabling low-cost and long-lived instrumentation that supports sustainable and scalable IoT applications.

Uptake Technologies, Inc. is a technology company that specializes in developing a predictive analytics platform designed to enhance operational efficiency across various industries, including healthcare, insurance, locomotives, construction, and manufacturing. Founded in 2014 and headquartered in Chicago, Illinois, Uptake's platform analyzes sensor data to predict and prevent equipment failures, identify hidden profit opportunities, and uncover new growth avenues. By transforming data into actionable insights, the platform facilitates equipment monitoring, diagnostic troubleshooting, event and condition prediction, and task management, ultimately improving uptime and streamlining operations for its clients.

Collective Health is a prominent health benefits platform that streamlines the management of medical, dental, vision, and pharmacy services for employees and their families. By offering an integrated solution through a cloud-based self-insurance platform, the company simplifies the administration of health plans via a single portal. This platform provides users with clear guidance, live concierge support, and digital tools to facilitate the navigation and management of healthcare services. Collective Health aims to reduce the complexities of delivering health benefits, enhance the member experience, and promote healthier outcomes for both employees and organizations. Headquartered in San Francisco, California, the company also has offices in Chicago, Illinois, and Lehi, Utah.

Mighty AI, Inc. operates a Training Data as a Service platform that assists businesses in acquiring the datasets necessary to train and enhance their computer vision and natural language models. The company's platform features a global community of individuals who perform micro tasks, such as labeling objects in images and conducting sentiment analysis on text. By leveraging its proprietary machine learning technology and a comprehensive suite of annotation software, Mighty AI ensures high accuracy and scalability in the data it provides. Founded in 2014 and headquartered in Seattle, Washington, with an additional office in Detroit, Michigan, Mighty AI serves customers worldwide and specializes in delivering training data for companies developing computer vision models, particularly for autonomous vehicles. The company was previously known as Spare5 Inc. and became a subsidiary of Uber Technologies, Inc. in 2019.

Collective Health is a prominent health benefits platform that streamlines the management of medical, dental, vision, and pharmacy services for employees and their families. By offering an integrated solution through a cloud-based self-insurance platform, the company simplifies the administration of health plans via a single portal. This platform provides users with clear guidance, live concierge support, and digital tools to facilitate the navigation and management of healthcare services. Collective Health aims to reduce the complexities of delivering health benefits, enhance the member experience, and promote healthier outcomes for both employees and organizations. Headquartered in San Francisco, California, the company also has offices in Chicago, Illinois, and Lehi, Utah.

Collective Health is a prominent health benefits platform that streamlines the management of medical, dental, vision, and pharmacy services for employees and their families. By offering an integrated solution through a cloud-based self-insurance platform, the company simplifies the administration of health plans via a single portal. This platform provides users with clear guidance, live concierge support, and digital tools to facilitate the navigation and management of healthcare services. Collective Health aims to reduce the complexities of delivering health benefits, enhance the member experience, and promote healthier outcomes for both employees and organizations. Headquartered in San Francisco, California, the company also has offices in Chicago, Illinois, and Lehi, Utah.

Mighty AI, Inc. operates a Training Data as a Service platform that assists businesses in acquiring the datasets necessary to train and enhance their computer vision and natural language models. The company's platform features a global community of individuals who perform micro tasks, such as labeling objects in images and conducting sentiment analysis on text. By leveraging its proprietary machine learning technology and a comprehensive suite of annotation software, Mighty AI ensures high accuracy and scalability in the data it provides. Founded in 2014 and headquartered in Seattle, Washington, with an additional office in Detroit, Michigan, Mighty AI serves customers worldwide and specializes in delivering training data for companies developing computer vision models, particularly for autonomous vehicles. The company was previously known as Spare5 Inc. and became a subsidiary of Uber Technologies, Inc. in 2019.

Everactive, Inc., also known as Everactive Insights, Inc., specializes in the development of wireless sensing devices and technologies tailored for Industrial Internet of Things (IoT) applications. The company produces ultra-low-power chips that enable battery-less wireless sensors, facilitating data generation and analytics for various industrial operations. Its innovations include PsiKick integrated circuits, which support programmable processing, power management, and RF communication. Everactive's solutions encompass steam trap monitoring, flare system monitoring, and machine health monitoring, allowing for continuous analysis of industrial assets. Founded in 2012 and headquartered in Santa Clara, California, Everactive also has locations in Charlottesville, Virginia, and Ann Arbor, Michigan. The company’s technology is based on energy harvesting, enabling low-cost and long-lived instrumentation that supports sustainable and scalable IoT applications.

Rotation Medical Inc. is a medical device company based in Plymouth, Minnesota, specializing in the development of a minimally invasive rotator cuff implant system designed for the treatment of rotator cuff diseases. The company's primary product is a collagen scaffold that is affixed to the affected rotator cuff tendon, aimed at managing tendon injuries and providing protection for both small and larger rotator cuff tears. Founded in 2009 and initially known as Denali Medical Inc., the company rebranded to Rotation Medical in March 2010. As of December 2017, Rotation Medical operates as a subsidiary of Smith & Nephew plc.

Lumos Pharma, Inc. is a clinical-stage biopharmaceutical company based in Austin, Texas, focused on developing and commercializing therapeutics for severe, rare, and genetic diseases. The company's lead product, LUM-201, is an oral small molecule currently undergoing Phase 2 clinical trials for pediatric growth hormone deficiency. In addition to its primary focus, Lumos has a licensing agreement with Ellipses Pharma Limited for the development and commercialization of nanoparticle formulations aimed at oncology indications. Founded in 2011, Lumos Pharma also has a commitment to addressing Creatine Transporter Deficiency, leveraging exclusive licenses for technologies developed at the University of Cincinnati and collaborating with key opinion leaders and the National Institutes of Health. The company engages in both clinical and preclinical research, exploring treatments that may enhance immune responses against cancer, and has partnerships for manufacturing its therapeutics.

Collective Health is a prominent health benefits platform that streamlines the management of medical, dental, vision, and pharmacy services for employees and their families. By offering an integrated solution through a cloud-based self-insurance platform, the company simplifies the administration of health plans via a single portal. This platform provides users with clear guidance, live concierge support, and digital tools to facilitate the navigation and management of healthcare services. Collective Health aims to reduce the complexities of delivering health benefits, enhance the member experience, and promote healthier outcomes for both employees and organizations. Headquartered in San Francisco, California, the company also has offices in Chicago, Illinois, and Lehi, Utah.

Hatch Loyalty Inc. is a provider of a loyalty and rewards platform aimed at small and medium-sized businesses, enabling them to create customized loyalty programs and execute effective marketing campaigns. Founded in 2011 and headquartered in Chicago, Illinois, Hatch offers a suite of tools, including HatchHQ, HatchIQ, and HatchHUB, designed to enhance customer engagement and foster meaningful relationships. The platform also features the industry-leading solution, Belly, which provides off-the-shelf marketing capabilities for businesses. Hatch Loyalty focuses on making customer insights actionable, allowing retailers to tailor experiences and drive loyalty through data-driven decision-making. Previously known as Belly Inc., the company rebranded in September 2017 and operates as a subsidiary of Stuzo Inc.

Cleversafe, Inc. specializes in developing web-scale storage solutions tailored for the demands of hyperscale environments. Founded in 2004 and based in Chicago, Illinois, the company provides a range of services including enterprise storage, content repository, and Storage-as-a-Service. Cleversafe's technology addresses the rapid growth of unstructured data, which is increasing by 60-80 percent annually, by enabling businesses to store, manage, and access data at petabyte scale and beyond. The company's solutions are designed for various industries, including financial services, healthcare, media, oil and gas, and government, ensuring significant improvements in economic efficiency, security, and operational simplicity. As of November 2015, Cleversafe operates as a subsidiary of International Business Machines Corporation.

CVRx, Inc. is a medical device company based in Minneapolis, Minnesota, that specializes in implantable technology for treating high blood pressure and heart failure. The company develops Barostim, a proprietary neuromodulation therapy that activates the body's natural reflexes to regulate blood pressure and address the progression of heart failure. This therapy is delivered through a long-lasting implant system that is tailored to meet individual patient needs. CVRx also manufactures the Rheos implantable pulse generator and associated components, which facilitate the delivery of activation energy to the carotid arteries. Founded in 2000, CVRx primarily serves patients and healthcare professionals in the United States and several European countries, focusing on minimally invasive solutions for cardiovascular diseases.

Apnex Medical, Inc. manufactures and markets medical devices such as implants for the treatment of obstructive sleep apnea. Apnex Medical, Inc. was incorporated in 2006 and is based in Saint Paul, Minnesota.

Upstart is a peer-to-peer online lending platform that utilizes artificial intelligence and machine learning to enhance the lending process. Founded in 2012 and based in San Mateo, California, the company focuses on providing fixed-rate personal loans by employing a proprietary underwriting model that evaluates factors such as education, area of study, and employment history, allowing it to identify borrowers with limited credit backgrounds. Upstart connects consumer loan demand with its network of AI-enabled bank partners, facilitating a streamlined borrowing experience. The platform supports a variety of loan offerings, including personal loans, automotive financing, home equity lines of credit, and small-dollar loans, enabling banks to achieve higher approval rates and reduced loss rates while enhancing customer satisfaction through a digital-first approach.

Say Media, Inc. is a digital publishing company that specializes in creating, distributing, and monetizing digital content. The company operates the Tempest publishing platform, which empowers independent content creators to develop engaged communities across various consumer interest areas, including Style, Living, Food, and Tech. Say Media offers innovative advertising solutions such as AdFrames, an expandable media ad unit designed to enhance reader engagement, and Portable Creative, which allows advertisers to utilize AdFrames on any trading desk. With a global reach exceeding 400 million people, Say Media provides brands with effective and accountable ways to connect with target audiences. Founded in 2004 and originally known as VideoEgg, Say Media is headquartered in San Francisco, with additional offices in New York, Chicago, London, Toronto, and Portland. The company operates as a subsidiary of TheMaven, Inc.

Eventup, Inc. operates an online marketplace that facilitates the booking of diverse event venues across the United States. Founded in 2011 and headquartered in Santa Monica, California, the platform features a wide range of locations, including homes, apartments, lofts, hotels, galleries, and unique spaces suitable for various events such as weddings, corporate gatherings, and parties. By connecting property owners directly with clients, Eventup simplifies the venue selection process, allowing users to discover and book locations quickly and efficiently. Its comprehensive approach addresses the challenges of a fragmented market, enabling venue operators to monetize underutilized spaces while providing customers access to distinctive and previously hard-to-find venues. The company's operations extend to major cities including Los Angeles, New York, San Francisco, and Chicago, and it functions as a subsidiary of Gather Technologies, Inc.

Relievant Medsystems, Inc. is a medical device company focused on developing minimally invasive treatments for chronic axial low back pain. The company has created the Intracept procedure, which specifically targets the basivertebral nerve to alleviate chronic vertebrogenic low back pain. By delivering targeted energy into the spine, the Intracept System effectively blocks the transmission of pain signals, providing patients with a low-risk therapeutic option. Founded in 2004, Relievant is headquartered in Minneapolis, Minnesota, with additional operations in Sunnyvale, California.

Apnex Medical, Inc. manufactures and markets medical devices such as implants for the treatment of obstructive sleep apnea. Apnex Medical, Inc. was incorporated in 2006 and is based in Saint Paul, Minnesota.

BridgePoint Medical, a private company with headquarters in Minneapolis, Minnesota, is focused on developing innovative and proprietary technology in the field of interventional cardiology for access to and treatment of chronic total occlusions.

Groupon, Inc. operates as an online local commerce marketplace that connects consumers with merchants by offering discounts on a wide array of goods and services both in North America and internationally. The company features deals across various categories, including events, health and wellness, food, home goods, automotive services, and travel packages, among others. Groupon enables consumers to access and redeem these offers through its website, mobile applications, emails, and advertising channels. It serves as an intermediary, facilitating transactions between consumers and merchants, earning revenue through commissions on sales and digital coupon redemptions. Founded in 2008 and headquartered in Chicago, Groupon offers a diverse marketplace aimed at enhancing consumer experiences while assisting local businesses in reaching their target audience.

Cleversafe, Inc. specializes in developing web-scale storage solutions tailored for the demands of hyperscale environments. Founded in 2004 and based in Chicago, Illinois, the company provides a range of services including enterprise storage, content repository, and Storage-as-a-Service. Cleversafe's technology addresses the rapid growth of unstructured data, which is increasing by 60-80 percent annually, by enabling businesses to store, manage, and access data at petabyte scale and beyond. The company's solutions are designed for various industries, including financial services, healthcare, media, oil and gas, and government, ensuring significant improvements in economic efficiency, security, and operational simplicity. As of November 2015, Cleversafe operates as a subsidiary of International Business Machines Corporation.

Groupon, Inc. operates as an online local commerce marketplace that connects consumers with merchants by offering discounts on a wide array of goods and services both in North America and internationally. The company features deals across various categories, including events, health and wellness, food, home goods, automotive services, and travel packages, among others. Groupon enables consumers to access and redeem these offers through its website, mobile applications, emails, and advertising channels. It serves as an intermediary, facilitating transactions between consumers and merchants, earning revenue through commissions on sales and digital coupon redemptions. Founded in 2008 and headquartered in Chicago, Groupon offers a diverse marketplace aimed at enhancing consumer experiences while assisting local businesses in reaching their target audience.

Apnex Medical, Inc. manufactures and markets medical devices such as implants for the treatment of obstructive sleep apnea. Apnex Medical, Inc. was incorporated in 2006 and is based in Saint Paul, Minnesota.

Groupon, Inc. operates as an online local commerce marketplace that connects consumers with merchants by offering discounts on a wide array of goods and services both in North America and internationally. The company features deals across various categories, including events, health and wellness, food, home goods, automotive services, and travel packages, among others. Groupon enables consumers to access and redeem these offers through its website, mobile applications, emails, and advertising channels. It serves as an intermediary, facilitating transactions between consumers and merchants, earning revenue through commissions on sales and digital coupon redemptions. Founded in 2008 and headquartered in Chicago, Groupon offers a diverse marketplace aimed at enhancing consumer experiences while assisting local businesses in reaching their target audience.

BridgePoint Medical, a private company with headquarters in Minneapolis, Minnesota, is focused on developing innovative and proprietary technology in the field of interventional cardiology for access to and treatment of chronic total occlusions.

CVRx, Inc. is a medical device company based in Minneapolis, Minnesota, that specializes in implantable technology for treating high blood pressure and heart failure. The company develops Barostim, a proprietary neuromodulation therapy that activates the body's natural reflexes to regulate blood pressure and address the progression of heart failure. This therapy is delivered through a long-lasting implant system that is tailored to meet individual patient needs. CVRx also manufactures the Rheos implantable pulse generator and associated components, which facilitate the delivery of activation energy to the carotid arteries. Founded in 2000, CVRx primarily serves patients and healthcare professionals in the United States and several European countries, focusing on minimally invasive solutions for cardiovascular diseases.

Groupon, Inc. operates as an online local commerce marketplace that connects consumers with merchants by offering discounts on a wide array of goods and services both in North America and internationally. The company features deals across various categories, including events, health and wellness, food, home goods, automotive services, and travel packages, among others. Groupon enables consumers to access and redeem these offers through its website, mobile applications, emails, and advertising channels. It serves as an intermediary, facilitating transactions between consumers and merchants, earning revenue through commissions on sales and digital coupon redemptions. Founded in 2008 and headquartered in Chicago, Groupon offers a diverse marketplace aimed at enhancing consumer experiences while assisting local businesses in reaching their target audience.

Cleversafe, Inc. specializes in developing web-scale storage solutions tailored for the demands of hyperscale environments. Founded in 2004 and based in Chicago, Illinois, the company provides a range of services including enterprise storage, content repository, and Storage-as-a-Service. Cleversafe's technology addresses the rapid growth of unstructured data, which is increasing by 60-80 percent annually, by enabling businesses to store, manage, and access data at petabyte scale and beyond. The company's solutions are designed for various industries, including financial services, healthcare, media, oil and gas, and government, ensuring significant improvements in economic efficiency, security, and operational simplicity. As of November 2015, Cleversafe operates as a subsidiary of International Business Machines Corporation.

Jentro Technologies GmbH, founded in 2003 and headquartered in Munich, Germany, specializes in providing GPS-based mobile navigation solutions to mobile communication companies across Europe and internationally. The company offers a comprehensive Mobility Solutions Platform that includes global maps, GPS connectivity, and user management APIs. Their products feature the Activepilot online navigation solution, which encompasses hardware design, client software, and backend services, along with Bluetooth and cable GPS receivers. Jentro's Navigation Suite provides turn-by-turn navigation, integrated traffic updates, and local search applications, while additional offerings include community features, travel information, and emergency services. The company also provides value-added services such as support, billing management, and marketing assistance. Jentro Technologies has established strategic partnerships with key industry players, enhancing its service capabilities and market reach.

Apnex Medical, Inc. manufactures and markets medical devices such as implants for the treatment of obstructive sleep apnea. Apnex Medical, Inc. was incorporated in 2006 and is based in Saint Paul, Minnesota.

CVRx, Inc. is a medical device company based in Minneapolis, Minnesota, that specializes in implantable technology for treating high blood pressure and heart failure. The company develops Barostim, a proprietary neuromodulation therapy that activates the body's natural reflexes to regulate blood pressure and address the progression of heart failure. This therapy is delivered through a long-lasting implant system that is tailored to meet individual patient needs. CVRx also manufactures the Rheos implantable pulse generator and associated components, which facilitate the delivery of activation energy to the carotid arteries. Founded in 2000, CVRx primarily serves patients and healthcare professionals in the United States and several European countries, focusing on minimally invasive solutions for cardiovascular diseases.

BridgePoint Medical, a private company with headquarters in Minneapolis, Minnesota, is focused on developing innovative and proprietary technology in the field of interventional cardiology for access to and treatment of chronic total occlusions.

Cleversafe, Inc. specializes in developing web-scale storage solutions tailored for the demands of hyperscale environments. Founded in 2004 and based in Chicago, Illinois, the company provides a range of services including enterprise storage, content repository, and Storage-as-a-Service. Cleversafe's technology addresses the rapid growth of unstructured data, which is increasing by 60-80 percent annually, by enabling businesses to store, manage, and access data at petabyte scale and beyond. The company's solutions are designed for various industries, including financial services, healthcare, media, oil and gas, and government, ensuring significant improvements in economic efficiency, security, and operational simplicity. As of November 2015, Cleversafe operates as a subsidiary of International Business Machines Corporation.

U4EA Wireless, provides WiFi mobility solutions and networking protocol software for the wired and wireless communications market. It offers GateD, a routing and switching software; and wireless controller switching software, for WPA. The company also provides professional services, such as porting, integration, testing, feature acceleration, and product consultation. NextHop offers its products and services to mobile enterprise and carrier equipment manufacturers. It has locations in Ann Arbor, Michigan; and Bangalore, India. The company was founded in 2000 and is headquartered in Mountain View, California. The company also has sales offices in Acton, Massachusetts; Beijing, China; Oxford, the United Kingdom; and Taipei, Taiwan.

BridgePoint Medical, a private company with headquarters in Minneapolis, Minnesota, is focused on developing innovative and proprietary technology in the field of interventional cardiology for access to and treatment of chronic total occlusions.

Inteliquent is an interconnection provider based in Chicago, Illinois, that specializes in facilitating voice communications for service providers and enterprises. Established in 2003 by Ron Gavillet, the company operates a robust, geo-diverse, carrier-grade tier 1 network, directly connected to all major telecom carriers, and covering 94 percent of the US population. Inteliquent offers two primary service areas: Communications-Platform-as-a-Service (CPaaS), which provides API-based voice calling and phone number services, and more traditional Infrastructure-as-a-Service (IaaS) solutions for telecommunications companies, including off-net call termination. The platform manages over 300 billion minutes of voice calls annually and has registered more than 100 million active phone numbers for its clients. Additionally, Inteliquent delivers a range of voice services such as local transit, long-distance, international voice, and toll-free services, all utilizing an all-IP network.

Scalix is a provider of email, group calendaring, and messaging solutions specifically designed for the Linux platform. The company offers a robust and scalable messaging system that integrates seamlessly with existing messaging clients and infrastructure. Scalix's solutions include ActiveSync, which allows for server-side synchronization with Microsoft Exchange, and the Univention Edition that facilitates the deployment and management of Linux-based server and client solutions for businesses and public organizations. Founded by a team with extensive experience in the messaging sector, Scalix leverages a proven technology foundation from HP OpenMail. The privately held company is headquartered in San Mateo, California, and has additional offices in New York, Chicago, the United Kingdom, and Germany.

U4EA Wireless, provides WiFi mobility solutions and networking protocol software for the wired and wireless communications market. It offers GateD, a routing and switching software; and wireless controller switching software, for WPA. The company also provides professional services, such as porting, integration, testing, feature acceleration, and product consultation. NextHop offers its products and services to mobile enterprise and carrier equipment manufacturers. It has locations in Ann Arbor, Michigan; and Bangalore, India. The company was founded in 2000 and is headquartered in Mountain View, California. The company also has sales offices in Acton, Massachusetts; Beijing, China; Oxford, the United Kingdom; and Taipei, Taiwan.

Prospex Medical was a medical device incubator based in Stillwater, Minnesota, focused on innovating and developing novel medical technologies. The firm specialized in both regulated and quasi-consumer medical products, engaging in market identification, clinical and technical research, and collaboration with physicians. Through its comprehensive approach, Prospex Medical generated intellectual property and established proof of concept for its projects. The incubator successfully created and spun out two companies, BridgePoint Medical and Apnex Medical, contributing to advancements in the healthcare sector. Although currently dormant, Prospex Medical played a significant role in fostering innovation within the medical device industry.

Informance International, Inc. specializes in providing enterprise manufacturing intelligence solutions for manufacturers both in the United States and globally. The company offers a range of products designed to enhance operational efficiency, including the Enterprise Solution, which serves as a strategic decision support system for supply chain and manufacturing executives to identify and act on opportunities within their plant networks. Additionally, the Discrete Manufacturing Module assists plant staff in improving discrete manufacturing processes, while the Process Manufacturing Module focuses on continuous manufacturing operations. Informance also provides the Enterprise Synchronizer, a web services-based platform that facilitates integration across various systems and applications. Founded in 1995 and headquartered in Northbrook, Illinois, Informance International, Inc. operates as a subsidiary of Solarsoft Business Systems Limited since 2010.

InnerWorkings, Inc. is a prominent provider of global print management and promotional solutions for corporate clients across various industries. The company specializes in marketing supply-chain services, offering a range of products including advertising materials, branded merchandise, product packaging, and retail displays. With its proprietary technology and extensive supplier network, InnerWorkings efficiently procures, manages, and delivers printed materials as part of an outsourced enterprise solution. The company generates most of its revenue from its North America segment and operates in three geographical areas: North America, EMEA, and LATAM. Additionally, InnerWorkings runs an online business printing platform called Inkchaser.com and utilizes a software platform named VALO, which assists customers in sourcing, producing, monitoring, and analyzing their marketing plans. Headquartered in Chicago, Illinois, InnerWorkings maintains 35 offices across North America, South America, and Europe.

U4EA Wireless, provides WiFi mobility solutions and networking protocol software for the wired and wireless communications market. It offers GateD, a routing and switching software; and wireless controller switching software, for WPA. The company also provides professional services, such as porting, integration, testing, feature acceleration, and product consultation. NextHop offers its products and services to mobile enterprise and carrier equipment manufacturers. It has locations in Ann Arbor, Michigan; and Bangalore, India. The company was founded in 2000 and is headquartered in Mountain View, California. The company also has sales offices in Acton, Massachusetts; Beijing, China; Oxford, the United Kingdom; and Taipei, Taiwan.

MusicNow is an online digital music service that enables users to browse, discover, and download tracks through a subscription-based model. Founded by Chris Gladwin in 1999 and headquartered in Chicago, Illinois, MusicNow focuses on providing a personalized music experience, allowing customers to access a customized library. In November 2005, the company was acquired by AOL, which subsequently rebranded it as the AOLMusicNow product.

Scalix is a provider of email, group calendaring, and messaging solutions specifically designed for the Linux platform. The company offers a robust and scalable messaging system that integrates seamlessly with existing messaging clients and infrastructure. Scalix's solutions include ActiveSync, which allows for server-side synchronization with Microsoft Exchange, and the Univention Edition that facilitates the deployment and management of Linux-based server and client solutions for businesses and public organizations. Founded by a team with extensive experience in the messaging sector, Scalix leverages a proven technology foundation from HP OpenMail. The privately held company is headquartered in San Mateo, California, and has additional offices in New York, Chicago, the United Kingdom, and Germany.

MusicNow is an online digital music service that enables users to browse, discover, and download tracks through a subscription-based model. Founded by Chris Gladwin in 1999 and headquartered in Chicago, Illinois, MusicNow focuses on providing a personalized music experience, allowing customers to access a customized library. In November 2005, the company was acquired by AOL, which subsequently rebranded it as the AOLMusicNow product.

U4EA Wireless, provides WiFi mobility solutions and networking protocol software for the wired and wireless communications market. It offers GateD, a routing and switching software; and wireless controller switching software, for WPA. The company also provides professional services, such as porting, integration, testing, feature acceleration, and product consultation. NextHop offers its products and services to mobile enterprise and carrier equipment manufacturers. It has locations in Ann Arbor, Michigan; and Bangalore, India. The company was founded in 2000 and is headquartered in Mountain View, California. The company also has sales offices in Acton, Massachusetts; Beijing, China; Oxford, the United Kingdom; and Taipei, Taiwan.

MusicNow is an online digital music service that enables users to browse, discover, and download tracks through a subscription-based model. Founded by Chris Gladwin in 1999 and headquartered in Chicago, Illinois, MusicNow focuses on providing a personalized music experience, allowing customers to access a customized library. In November 2005, the company was acquired by AOL, which subsequently rebranded it as the AOLMusicNow product.

MusicNow is an online digital music service that enables users to browse, discover, and download tracks through a subscription-based model. Founded by Chris Gladwin in 1999 and headquartered in Chicago, Illinois, MusicNow focuses on providing a personalized music experience, allowing customers to access a customized library. In November 2005, the company was acquired by AOL, which subsequently rebranded it as the AOLMusicNow product.

MusicNow is an online digital music service that enables users to browse, discover, and download tracks through a subscription-based model. Founded by Chris Gladwin in 1999 and headquartered in Chicago, Illinois, MusicNow focuses on providing a personalized music experience, allowing customers to access a customized library. In November 2005, the company was acquired by AOL, which subsequently rebranded it as the AOLMusicNow product.

PPONEXT is a PPO services company that provides healthcare management and network services. PPONEXT offers access to a network of medical care providers, hospitals, and ancillary facilities to group health, workers' compensation, and other insurance payers in the Midwest, Texas, California, Florida, New Jersey, and Pennsylvania.

Broadwing Communications, founded in 1962, provides telecommunication services to enterprises, carriers, and government entities. The company operates two divisions: Broadwing Communications, LLC, offering data, internet, voice, and broadband transport services to carrier and enterprise customers across 137 cities, and Corvis Equipment Corporation, designing and selling high-performance optical and electrical/optical communications systems. In response to industry changes, Broadwing shifted its focus to primarily providing communication services, which now make up 99% of its revenue. In 2006, Broadwing Corporation was acquired by Level 3 Communications, marking a significant event in the company's history.