North Carolina Biotechnology Center

Atlantic Fish Company is focused on producing cultivated seafood through cellular agriculture, operating from its headquarters in Raleigh-Durham, North Carolina. The company aims to provide sustainable seafood options by cultivating fish in a controlled environment. This innovative approach allows Atlantic Fish Company to offer fresh fish meat that maintains the natural taste while minimizing the environmental impact associated with traditional fishing practices. By leveraging cellular agriculture, the company seeks to meet the growing demand for sustainable protein sources.

QATCH Technologies is a developer of innovative tools aimed at enhancing the biopharmaceutical industry. The company specializes in a proprietary pre-screening tool that utilizes advanced microfluidic sensor technology combined with acoustics. This technology allows for the precise processing of nanoliters of liquid, enabling researchers to assess the injectability and manufacturability of biopharmaceutical formulations at an early stage. By measuring viscosity and identifying potential manufacturing issues related to formulation, QATCH Technologies empowers biopharma researchers to select optimal injectable molecules while minimizing liquid volume requirements.

Phase provides 3D-printing medical devices for microfluidics. Phase’s proprietary platform enables PDMS (Sylgard 184) to be 3D printed at a scale and resolution that was previously unattainable.

Avior Bio is a clinical-stage pharmaceutical company focused on developing innovative therapies for distressed neurological conditions and associated symptoms, including pruritus resulting from liver disease. The company utilizes its proprietary Speedit™ Transmucosal Film Technology, which enhances drug delivery by avoiding first-pass metabolism and significantly reducing glucuronide metabolites excreted by the kidneys. This technology aims to provide effective relief from various conditions, such as insomnia, anxiety, depression, and skin excoriation, thus offering improved efficacy and safety for patients. With a strong management team, an experienced advisory board, and a dedicated group of scientists and clinicians, Avior Bio is well-positioned to advance its mission of delivering high-value therapeutic solutions.

Duke University is a private research university located in Durham, North Carolina. With approximately 15,000 students and a renowned faculty, Duke is dedicated to pushing the boundaries of knowledge and making a positive impact on society. The university's Office of News and Communications, along with Duke Web Services, played a key role in developing the university's web presence, collaborating with Viget Labs to create a cohesive design. Duke offers free tools to help members of the community align their websites with the university's branding, including messaging and style guidelines, color palettes, typefaces, web templates, and information on using the "Duke brand bar." For further details, individuals can refer to the online style guide or reach out to Duke Web Services for assistance.

InSoma Bio integrates biology and materials science to solve problems in tissue engineering and regenerative medicine. It offers genetically engineer protein-based materials that can mimic the naturally found elastin found in extracellular tissues. The company also offers reconstructive plastic surgeries and injectable materials.

Founded in 2020, Amalgent Therapeutics is a biopharmaceutical company based in Chapel Hill, North Carolina. It specializes in developing combination drugs for pain management that significantly reduce required doses and minimize side effects.

IngateyGen is an agricultural biotechnology company focused on developing hypoallergenic and allergen-reduced peanuts and allergen-free peanut butter. Using proprietary technologies in genomics, proteomics, plant tissue culture, and plant propagation, the company aims to create peanut varieties and consumer products that reduce allergens and improve safety for individuals with peanut sensitivities, while pursuing scalable agricultural solutions for the food industry.

Lacuna Medical has created a 3D shape catheter that is more resistant to catheter failure. The 3D shape protection uses memory shape to the protect the proximal holes of the catheter.

Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

The University of North Carolina at Chapel Hill, established in 1789, is the first public university in the United States and operates as a non-profit educational institution. It is dedicated to teaching, research, and public service, serving a diverse community of undergraduate, graduate, and professional students. The university's mission is to foster scholarship and creativity while preparing future leaders to contribute positively to society. With a strong commitment to excellence, it leverages the expertise of its faculty and staff to enhance access to education and promote the success of its students. Additionally, the university manages an endowment fund that supports various initiatives, including scholarships, fellowships, professorships, and research across multiple disciplines. Through its outreach efforts, UNC Chapel Hill aims to improve the quality of life for the citizens of North Carolina and beyond.

North Carolina Central University, founded in 1910 in Durham, North Carolina, is a historically black university that offers more than 100 undergraduate and graduate programs across nearly 30 academic departments. It is known for distinctive degrees such as a master’s in Jazz Studies and a bachelor’s in Apparel Design, as well as joint graduate programs that combine law, business, library science, and information science. The university provides a range of financial aid options, including need‑based government assistance and institutional scholarships, and encourages applications from students of all races and ethnicities. With a focus on academic excellence, research, and cultural awareness, the institution maintains a diverse student body and a commitment to inclusive education.

Belhaven Biopharma is a biotechnology company focused on developing innovative treatments for anaphylaxis. The company specializes in the production and scale-up of clinical trial materials, as well as the preparation and filing of Investigational New Drug applications. Belhaven is advancing a portfolio of dry powder intranasal medications designed to offer convenient and rapid administration during emergencies. This approach aims to ensure that patients can receive effective treatment quickly, enhancing the safety and accessibility of life-saving medication in critical situations.

Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

The University of North Carolina at Greensboro, also known as UNCG and UNC Greensboro, is a public coeducational and research university in Greensboro in North Carolina in the United States of America, and it is a constituent institution of the system of the University of North Carolina. However, the University of North Carolina at Greensboro is a stand-alone university and awards its own degrees like all members of the system of the University of North Carolina . The Southern Association of Colleges and Schools Commission on Colleges accredits the University of North Carolina at Greensboro to award baccalaureate, masters, specialist, and doctoral degrees.

The University of North Carolina at Chapel Hill, established in 1789, is the first public university in the United States and operates as a non-profit educational institution. It is dedicated to teaching, research, and public service, serving a diverse community of undergraduate, graduate, and professional students. The university's mission is to foster scholarship and creativity while preparing future leaders to contribute positively to society. With a strong commitment to excellence, it leverages the expertise of its faculty and staff to enhance access to education and promote the success of its students. Additionally, the university manages an endowment fund that supports various initiatives, including scholarships, fellowships, professorships, and research across multiple disciplines. Through its outreach efforts, UNC Chapel Hill aims to improve the quality of life for the citizens of North Carolina and beyond.

The University of North Carolina Wilmington, the state's coastal university, is dedicated to the integration of teaching and mentoring with research and service. University of North Carolina Wilmington, commitment to student engagement, creative inquiry, critical thinking, thoughtful expression and responsible citizenship is expressed in our baccalaureate and master's programs, as well as doctoral programs in areas of expertise that serve state needs. Our culture reflects our values of diversity and globalization, ethics and integrity, and excellence and innovation.

Sigma Xi is an international honor society for scientists and engineers. It also provides grants annually to promising young researchers and sponsors a variety of programs supporting ethics in research, science, and engineering education.

University of North Carolina at Asheville is a co-educational, four year, public liberal arts university.

Coprata is a digital health and technology platform that offers innovative solutions for gut health monitoring through hands-free stool sampling and automated bowel movement analysis. By utilizing artificial intelligence and normal toilet usage, the company enables individuals to track their gut health and understand the impact of lifestyle choices, providing early warnings of potential health changes. Coprata's technology focuses on detecting and managing both acute and chronic gastrointestinal diseases while also offering insights into infectious diseases. With an emphasis on non-invasive methods, the platform allows for discreet health monitoring without significantly altering daily routines. The company aims to enhance personalized wellness and explores future applications in preventative health and remote patient monitoring.

Enzerna Biosciences is a biotechnology company based in Morrisville, North Carolina, specializing in gene therapy solutions. The company focuses on addressing nucleotide expansion disorders by utilizing Artificial Site-Specific RNA Endonucleases (ASREs). These engineered proteins are designed to target and eliminate toxic RNA molecules responsible for these disorders, offering a potential long-term curative approach. Enzerna's innovative RNA editing technology and related products aim to provide effective treatments for genetic diseases.

Oncotect is a biotechnology company based in Raleigh, North Carolina. It specializes in pioneering early screening of cancer risks in dogs using their urine. The company's patent-pending in-vitro scientific test combines proprietary technology with the olfactory receptors of C. elegans to detect cancerous volatile metabolites.

UNC Charlotte is North Carolina's urban research university. It leverages its location in the state's largest city to offer internationally competitive programs of research and creative activity, exemplary undergraduate, graduate and professional programs, and a focused set of community engagement initiatives. UNC Charlotte maintains a particular commitment to addressing the cultural, economic, educational, environmental, health, and social needs of the greater Charlotte region.

Plakous Therapeutics specializes in regenerative healing, developing bio-therapeutics from post-delivery human placentas. Its flagship product, Protego-PD, is an orally delivered acellular biotherapeutic containing cytokines and growth factors to promote healing. Founded in 2016, the company is headquartered in Winston-Salem, North Carolina.

Plakous Therapeutics specializes in regenerative healing, developing bio-therapeutics from post-delivery human placentas. Its flagship product, Protego-PD, is an orally delivered acellular biotherapeutic containing cytokines and growth factors to promote healing. Founded in 2016, the company is headquartered in Winston-Salem, North Carolina.

Renaissance Fiber is a manufacturer specializing in the production of high-quality fiber derived from domestically sourced industrial hemp. Utilizing proprietary methods, the company ensures its processes are environmentally friendly, cost-effective, and scalable. The resulting fiber is versatile, suitable for a broad spectrum of applications in textiles and technical fibers, enabling businesses to adopt sustainable manufacturing practices at a competitive price point.

Coprata is a digital health and technology platform that offers innovative solutions for gut health monitoring through hands-free stool sampling and automated bowel movement analysis. By utilizing artificial intelligence and normal toilet usage, the company enables individuals to track their gut health and understand the impact of lifestyle choices, providing early warnings of potential health changes. Coprata's technology focuses on detecting and managing both acute and chronic gastrointestinal diseases while also offering insights into infectious diseases. With an emphasis on non-invasive methods, the platform allows for discreet health monitoring without significantly altering daily routines. The company aims to enhance personalized wellness and explores future applications in preventative health and remote patient monitoring.

Plakous Therapeutics specializes in regenerative healing, developing bio-therapeutics from post-delivery human placentas. Its flagship product, Protego-PD, is an orally delivered acellular biotherapeutic containing cytokines and growth factors to promote healing. Founded in 2016, the company is headquartered in Winston-Salem, North Carolina.

Kepley BioSystems is a biotechnology company focused on developing innovative solutions to address critical challenges in ocean health and public safety. It specializes in ocean restorative technology aimed at combating the depletion of wild fish populations. Additionally, the company has created a life science platform that offers accurate methods for testing dangerous endotoxins. This platform enables advancements in healthcare by providing rapid and sensitive diagnostics for blood-borne pathogens, assisting physicians in the detection of bloodstream infections. Through its dual focus on environmental restoration and healthcare innovation, Kepley BioSystems aims to contribute significantly to both marine ecosystems and public health.

The Company is focused on the commercialization of its first oncology application: treatment of advanced hepatocellular carcinoma. It has completed a phase II study, which shows effectiveness as well as excellent tolerability, even in previously treated patients with severely impaired liver function. See less

Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

The University of North Carolina Wilmington, the state's coastal university, is dedicated to the integration of teaching and mentoring with research and service. University of North Carolina Wilmington, commitment to student engagement, creative inquiry, critical thinking, thoughtful expression and responsible citizenship is expressed in our baccalaureate and master's programs, as well as doctoral programs in areas of expertise that serve state needs. Our culture reflects our values of diversity and globalization, ethics and integrity, and excellence and innovation.

Appalachian State University, located in Boone, North Carolina, provides a comprehensive educational experience with over 170 undergraduate and graduate degree programs. The university offers diverse majors, including Actuarial Science, Archaeology, Nursing, and Theatre Arts, emphasizing both academic rigor and cultural enrichment. In addition to its academic offerings, Appalachian State hosts a variety of cultural activities such as concerts, literary readings, and theatre productions, along with events like a Summer Arts festival and a performing arts series. The university is selective in its admissions process, with a competitive average GPA of 3.94 and SAT score of 1141 among incoming students. Financial aid is available through institutional scholarships based on academic merit and extracurricular involvement, as well as federal aid options. The Appalachian State University Foundation, a non-profit organization, supports students through scholarships and academic program funding.

Founded in 2015, EncepHeal Therapeutics is a biopharmaceutical company based in Winston-Salem, North Carolina. It specializes in developing non-addictive therapeutic agents to treat substance use disorders and other mental health conditions. The company's primary focus is on creating medications for cocaine and methamphetamine addiction, aiming to provide safe, affordable, and effective treatment options.

North Carolina A&T State University is so many things to so many people, both in our state and around the country. North Carolina A&T State University is an HBCU. We are a top-flight research university, the largest historically black university (HBCU) in the country, the #1 producer of degrees awarded to African Americans in North Carolina and nationally recognized or our excellence in science, technology, mathematics and engineering (STEM) education. We are a diverse community, bound by intense pride and tradition, with fiercely loyal alumni who hold positions of importance and influence in companies and government agencies across the state, the country and the world. We are achievers, driven by a curious, limitless, fearless spirit that fuels discovery and innovation, resulting in 41 patents issued based on our research, as well as numerous spin-off and start-up companies. We are inclusive and welcoming, with students from many backgrounds and cultures, every part of our state, our nation and countries around the globe. We are passionate, driven by a desire to do more, be more and make more of a difference. Since we opened our doors in 1892, we have focused on giving every student the hands-on opportunities, core knowledge and global perspective that will lead them to make real and lasting change in their lives and the lives of others. At N.C. A&T, we have so much to be proud of, and you can learn more about those "Points of Pride" here. You can also use the links below to learn more about what makes N.C. A&T unique, from our leadership and history to our many rankings and recognitions.

RainBIO is a pioneering company specializing in ocular gene therapy aimed at addressing corneal blindness. The company has developed a novel treatment using adeno-associated virus (AAV) vector technology to directly enhance corneal cellular function. This innovative approach is designed to reverse and prevent vision loss in patients at risk of blindness due to various conditions affecting the cornea. By focusing on maintaining and restoring eyesight, RainBIO is positioned to make significant advancements in the field of ophthalmology, offering hope to individuals facing the threat of vision impairment.

The University of North Carolina at Chapel Hill, established in 1789, is the first public university in the United States and operates as a non-profit educational institution. It is dedicated to teaching, research, and public service, serving a diverse community of undergraduate, graduate, and professional students. The university's mission is to foster scholarship and creativity while preparing future leaders to contribute positively to society. With a strong commitment to excellence, it leverages the expertise of its faculty and staff to enhance access to education and promote the success of its students. Additionally, the university manages an endowment fund that supports various initiatives, including scholarships, fellowships, professorships, and research across multiple disciplines. Through its outreach efforts, UNC Chapel Hill aims to improve the quality of life for the citizens of North Carolina and beyond.

Belhaven Biopharma is a biotechnology company focused on developing innovative treatments for anaphylaxis. The company specializes in the production and scale-up of clinical trial materials, as well as the preparation and filing of Investigational New Drug applications. Belhaven is advancing a portfolio of dry powder intranasal medications designed to offer convenient and rapid administration during emergencies. This approach aims to ensure that patients can receive effective treatment quickly, enhancing the safety and accessibility of life-saving medication in critical situations.

Founded in 1907, East Carolina University is a public doctoral/research university based in Greenville, North Carolina. It offers a wide range of undergraduate and graduate programs across various disciplines including business, fine arts, health sciences, nursing, and medicine.

NabGen, Inc. is a biotechnology company based in North Carolina, focused on developing an innovative antibody suppression platform designed to address a critical challenge in gene therapy. The company aims to mitigate the impact of patient-derived anti-drug antibodies, which can obstruct the effectiveness of adeno-associated virus (AAV)-based therapeutics. By employing a novel protein-based approach, NabGen’s technology functions as a universal antibody suppressant, effectively targeting and neutralizing various antibody types, including neutralizing antibodies, without compromising patients' immune systems. This capability not only facilitates the successful administration of gene therapies for patients with pre-existing vector immunity but also opens doors for re-dosing opportunities that are currently limited. Through its advancements, NabGen strives to enhance the accessibility and efficacy of cutting-edge genetic treatments for a wider range of patients.

UNC Charlotte is North Carolina's urban research university. It leverages its location in the state's largest city to offer internationally competitive programs of research and creative activity, exemplary undergraduate, graduate and professional programs, and a focused set of community engagement initiatives. UNC Charlotte maintains a particular commitment to addressing the cultural, economic, educational, environmental, health, and social needs of the greater Charlotte region.

Helixomer is a biotechnology company focused on the design and development of functional nucleic acid nanostructures for applications in human health. The company specializes in creating innovative solutions, including RNA-based anticoagulants and antibody replacements. Notably, Helixomer has developed a thrombin inhibitor along with an antidote, which serves as a specific reversal agent for its anticoagulant products. Through its cutting-edge research and development, Helixomer aims to advance therapeutic options that enhance patient care and improve health outcomes.

Drive Therapeutics is a biotechnology company focused on developing therapies for retinal diseases. It develops treatments for wet age-related macular degeneration and diabetic retinopathy/diabetic macular edema, aiming to improve therapeutic efficacy while reducing dosing frequency to achieve better patient outcomes in retinal care.

APIE Therapeutics is a biotechnology company focused on the development and commercialization of innovative drug therapies that target the Apelin Receptor biased agonist. The company aims to activate the Apelinergic System, which plays a crucial role in the signaling pathways associated with microvascular diseases. By targeting the Apelin/APJ protective and post-injury repair signaling pathways, APIE Therapeutics seeks to pioneer anti-fibrosis therapies that can enhance patient care in pulmonary, cardiovascular, and metabolic diseases. The company's research endeavors are centered on improving the quality of life for patients by providing effective therapies that address significant unmet medical needs.

CasTag Biosciences is a biotechnology company that specializes in cell biology and regenerative medicine, with a focus on enhancing the speed of endogenous protein analysis. The company develops Adeno-associated virus kits that leverage a two-vector, clustered regularly interspaced short palindromic repeats-based gene editing technique known as homology-independent universal genome engineering. This innovative approach enables researchers to modify entire panels of proteins within cells and tissues, facilitating the study of novel genes across various experimental models. By providing advanced tools for protein analysis, CasTag Biosciences aims to accelerate scientific discovery and enhance understanding in the field of genetics.

Avior Bio is a clinical-stage pharmaceutical company focused on developing innovative therapies for distressed neurological conditions and associated symptoms, including pruritus resulting from liver disease. The company utilizes its proprietary Speedit™ Transmucosal Film Technology, which enhances drug delivery by avoiding first-pass metabolism and significantly reducing glucuronide metabolites excreted by the kidneys. This technology aims to provide effective relief from various conditions, such as insomnia, anxiety, depression, and skin excoriation, thus offering improved efficacy and safety for patients. With a strong management team, an experienced advisory board, and a dedicated group of scientists and clinicians, Avior Bio is well-positioned to advance its mission of delivering high-value therapeutic solutions.

Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

Chiesi USA is a pharmaceuticals company that specializes in the research and development of products aimed at addressing respiratory, inflammatory, and critical care diseases. The company is dedicated to the discovery, development, and commercialization of innovative therapies designed to treat conditions such as asthma by regulating the body's inflammatory response. By focusing on these therapeutic areas, Chiesi USA plays a significant role in advancing healthcare solutions within the pharmaceutical industry.

Founded in 2016, Lindy Biosciences specializes in developing protein-based therapeutic formulations using its proprietary Microglassification technology. This process converts proteins into stable, spherical microbeads, enabling high-concentration suspensions, encapsulation for controlled release, and dry powder pulmonary delivery.

Locus Biosciences is a biotechnology company focused on developing a CRISPR-engineered precision antibacterial platform aimed at transforming the treatment of bacterial diseases. The company integrates the antibacterial capabilities of CRISPR-Cas3 technology with the effective and safe delivery of bacteriophages, which are viruses that specifically target bacteria. This innovative approach allows for rapid initiation of treatment by physicians, leading to improved medical outcomes for patients. Through its advanced platform, Locus Biosciences seeks to address the challenges posed by pathogenic bacteria in a precise and targeted manner.

Isolere Bio, established in 2018, is a healthcare company specializing in biotherapeutic purification. Its core business involves simplifying and optimizing the manufacturing process of monoclonal antibodies and Adeno-Associated Viruses (AAVs) using Tangential Flow Filtration (TFF) technology. This streamlined approach aims to enhance global access to these vital drugs and research tools, while facilitating a seamless transition from laboratory-scale production to industrial-level output.

Higgs Boson is a digital health company that empowers individuals undergoing acute interventional or surgical procedures. It develops healthcare applications designed to enhance patient engagement, improve outcomes, and increase practice efficiencies.

PRA Health Sciences, established in 1976 and headquartered in Raleigh, North Carolina, is a leading global contract research organization (CRO). It offers comprehensive outsourced clinical development and data solution services to the biotechnology and pharmaceutical industries worldwide. PRA's extensive services span clinical research, including product registration, early development, and strategic solutions, as well as data solutions such as market intelligence, consulting, and technology-enabled products. With over 17,000 employees across 90 offices in six continents, PRA has supported more than 3,800 clinical trials and contributed to the approval of over 85 products since 2000. The company is known for its commitment to excellence and high-quality global service.

Virokine Therapeutics is a Biotechnology company.

BioAesthetics develops tissue-engineered nipple-areolar complex grafts to support breast reconstruction after mastectomy. The graft is designed as a scaffold for the patient's own cells to populate and regenerate the nipple and areola during reconstruction, aiming to improve cosmetic and reconstructive outcomes. The company originated as a Tulane University spin-out and was founded in 2015.

BiomedInnovations is a medical device company that makes precision air and fluid flow devices, including products for lung ventilators and ex-vivo organ and tissue perfusion.

Tellus Therapeutics is a biopharmaceutical company based in Hillsborough, North Carolina, founded in 2018. The company focuses on developing innovative small molecules derived from human maternal breast milk to address unmet medical needs in newborns, specifically targeting perinatal brain injury. Its lead drug candidate promotes the regeneration of myelin-producing oligodendrocytes and aims to reverse white matter injury in premature infants. This therapeutic approach enables healthcare providers to offer treatment to all babies at risk of brain injury, ultimately striving to improve neurodevelopmental outcomes for affected children.

Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

Founded in 1907, East Carolina University is a public doctoral/research university based in Greenville, North Carolina. It offers a wide range of undergraduate and graduate programs across various disciplines including business, fine arts, health sciences, nursing, and medicine.

The University of North Carolina Wilmington, the state's coastal university, is dedicated to the integration of teaching and mentoring with research and service. University of North Carolina Wilmington, commitment to student engagement, creative inquiry, critical thinking, thoughtful expression and responsible citizenship is expressed in our baccalaureate and master's programs, as well as doctoral programs in areas of expertise that serve state needs. Our culture reflects our values of diversity and globalization, ethics and integrity, and excellence and innovation.

UNC Charlotte is North Carolina's urban research university. It leverages its location in the state's largest city to offer internationally competitive programs of research and creative activity, exemplary undergraduate, graduate and professional programs, and a focused set of community engagement initiatives. UNC Charlotte maintains a particular commitment to addressing the cultural, economic, educational, environmental, health, and social needs of the greater Charlotte region.

The University of North Carolina at Chapel Hill, established in 1789, is the first public university in the United States and operates as a non-profit educational institution. It is dedicated to teaching, research, and public service, serving a diverse community of undergraduate, graduate, and professional students. The university's mission is to foster scholarship and creativity while preparing future leaders to contribute positively to society. With a strong commitment to excellence, it leverages the expertise of its faculty and staff to enhance access to education and promote the success of its students. Additionally, the university manages an endowment fund that supports various initiatives, including scholarships, fellowships, professorships, and research across multiple disciplines. Through its outreach efforts, UNC Chapel Hill aims to improve the quality of life for the citizens of North Carolina and beyond.

Cereius, Inc. is a pre-clinical stage biotechnology company based in Durham, North Carolina, focused on developing innovative small-molecule therapies for brain metastasis, particularly in patients with HER2-positive breast cancer. Incorporated in 2017, the company specializes in novel radiolabeling chemistries that enhance the uptake and retention of radionuclides in targeted tumors while reducing the absorption in healthy tissues. This approach significantly improves both the therapeutic index and the diagnostic contrast of targeting agents, enabling medical practitioners to more effectively treat solid tumor brain metastasis and potentially improve patient survival rates.

Duke BioRepository & Precision Pathology Center (BRPC), Duke’s largest human tissue biobank. BRPC stores samples from consented patients for use in research.

IngateyGen is an agricultural biotechnology company focused on developing hypoallergenic and allergen-reduced peanuts and allergen-free peanut butter. Using proprietary technologies in genomics, proteomics, plant tissue culture, and plant propagation, the company aims to create peanut varieties and consumer products that reduce allergens and improve safety for individuals with peanut sensitivities, while pursuing scalable agricultural solutions for the food industry.

Isolere Bio, established in 2018, is a healthcare company specializing in biotherapeutic purification. Its core business involves simplifying and optimizing the manufacturing process of monoclonal antibodies and Adeno-Associated Viruses (AAVs) using Tangential Flow Filtration (TFF) technology. This streamlined approach aims to enhance global access to these vital drugs and research tools, while facilitating a seamless transition from laboratory-scale production to industrial-level output.

Arrevus, Inc. is a clinical-stage biotechnology company based in Raleigh, North Carolina, dedicated to developing innovative therapies for orphan diseases, with a particular emphasis on addressing antibiotic resistance. Founded in 2015, the company’s product pipeline includes several novel treatments: ARV-1801, an oral formulation of fusidic acid aimed at treating pulmonary exacerbations in cystic fibrosis; ARV-1907, an inhaled fusidic acid formulation targeting persistent staphylococcus aureus lung infections in cystic fibrosis patients; ARV-1502, an engineered inhibitor of bacterial DnaK for cancer treatment; and ARV-1802, a leptin receptor antagonist also for cancer treatment. Arrevus focuses on diseases where antibiotic resistance poses significant clinical challenges and is committed to developing Designer Proline-rich Antimicrobial Peptide Chaperone Protein Inhibitors to combat these issues, ultimately enhancing treatment options for serious, life-threatening conditions.

Aniluxx Biotechnology, Inc. is a biopharmaceutical company focused on developing innovative topical therapeutics for companion animals affected by skin diseases. Founded in 2019 and based in Chapel Hill, North Carolina, the company aims to enhance the health and well-being of pets by creating treatments for conditions such as atopic dermatitis and osteoarthritis. Aniluxx Biotechnology’s approach leverages a pipeline of topically formulated therapeutics based on compounds that have demonstrated safety and efficacy in humans. These therapeutics are designed to be easy to apply and virtually unnoticeable, minimizing the harsh side effects often associated with systemic medicines. Through its commitment to improving animal care, Aniluxx Biotechnology seeks to provide pet owners with effective solutions for managing their pets' health issues.

IMMvention Therapeutix is a biotechnology company developing novel small molecule pan-inflammasome inhibitors for treating inflammatory diseases. Its platform technology harnesses the immune system via biodegradable biopolymeric nano/micro-particles, targeting auto-inflammatory ailments such as rheumatoid arthritis and osteoarthritis.

Founded in 2016, Emergo Therapeutics is a pharmaceutical company based in Durham, North Carolina. It specializes in developing drugs that modulate inflammatory cytokines to improve immune system functioning, with a focus on treating uncomplicated influenza and other infectious diseases.

AveXis, operating as Novartis Gene Therapies, Inc., is a biotechnology company focused on developing and commercializing gene therapies for rare and life-threatening neurological genetic diseases. Acquired by Novartis in 2018, the company specializes in innovative treatments such as motor neuron cell-targeted gene replacement therapy aimed at conditions like spinal muscular atrophy, Rett syndrome, and amyotrophic lateral sclerosis. These therapies are designed to assist healthcare institutions in addressing diseases that cause progressive muscle weakness, paralysis, and ultimately, death. Through its advancements in gene therapy, AveXis is dedicated to improving the lives of patients and families impacted by these severe genetic disorders.

Founded in 2010, Redbud Labs specializes in developing and manufacturing Micro-Electro-Mechanical Systems (MEMS) and microfluidics technologies for the life science industry. The company offers actuated surface-attached posts films for fluid manipulation and microfluidic technologies for biosensing, enabling small-volume sample collection, processing, and analysis.

TregTherapeutics is a preclinical stage company based in North Carolina that focuses on developing treatments for multiple sclerosis. The company is dedicated to creating a tolerogenic vaccine aimed at inducing immune tolerance and potentially curing the disease. TregTherapeutics utilizes a proprietary technology platform, based on an exclusive license from East Carolina University, which harnesses the power of T-regulator cells (Tregs) to modulate immune responses. This innovative approach seeks to reverse the inflammatory attacks on demyelinating lesions in multiple sclerosis patients while promoting an anti-inflammatory response. The company's goal is to significantly improve patient outcomes in the management of autoimmune and neurodegenerative diseases.

Dualogics is a biotechnology company based at the University of North Carolina at Chapel Hill, focused on the research and development of bispecific antibodies targeting oncology and autoimmune diseases. Utilizing a proprietary bispecific antibody technology, the company engineers new antibody therapeutics, diagnostics, and research tools that aim to offer enhanced properties compared to traditional methods. Dualogics collaborates with academic and industrial partners to develop and test a range of multifunctional therapies and reagents, striving to transform the treatment landscape for patients affected by autoimmune conditions and various types of cancers.

InnAVasc Medical, Inc., established in 2013 and headquartered in Durham, North Carolina, specializes in the design and development of medical devices for vascular access in hemodialysis. The company's primary product, the Bullet Proof Vascular Access Graft, is an arteriovenous graft featuring two multilayer cannulation chambers, engineered to resist posterior and sidewall needle penetration and injury, thereby enhancing the safety and longevity of vascular access for hemodialysis patients.

Avior Bio is a clinical-stage pharmaceutical company focused on developing innovative therapies for distressed neurological conditions and associated symptoms, including pruritus resulting from liver disease. The company utilizes its proprietary Speedit™ Transmucosal Film Technology, which enhances drug delivery by avoiding first-pass metabolism and significantly reducing glucuronide metabolites excreted by the kidneys. This technology aims to provide effective relief from various conditions, such as insomnia, anxiety, depression, and skin excoriation, thus offering improved efficacy and safety for patients. With a strong management team, an experienced advisory board, and a dedicated group of scientists and clinicians, Avior Bio is well-positioned to advance its mission of delivering high-value therapeutic solutions.

Cereius, Inc. is a pre-clinical stage biotechnology company based in Durham, North Carolina, focused on developing innovative small-molecule therapies for brain metastasis, particularly in patients with HER2-positive breast cancer. Incorporated in 2017, the company specializes in novel radiolabeling chemistries that enhance the uptake and retention of radionuclides in targeted tumors while reducing the absorption in healthy tissues. This approach significantly improves both the therapeutic index and the diagnostic contrast of targeting agents, enabling medical practitioners to more effectively treat solid tumor brain metastasis and potentially improve patient survival rates.

Locus Biosciences is a biotechnology company focused on developing a CRISPR-engineered precision antibacterial platform aimed at transforming the treatment of bacterial diseases. The company integrates the antibacterial capabilities of CRISPR-Cas3 technology with the effective and safe delivery of bacteriophages, which are viruses that specifically target bacteria. This innovative approach allows for rapid initiation of treatment by physicians, leading to improved medical outcomes for patients. Through its advanced platform, Locus Biosciences seeks to address the challenges posed by pathogenic bacteria in a precise and targeted manner.

Locus Biosciences is a biotechnology company focused on developing a CRISPR-engineered precision antibacterial platform aimed at transforming the treatment of bacterial diseases. The company integrates the antibacterial capabilities of CRISPR-Cas3 technology with the effective and safe delivery of bacteriophages, which are viruses that specifically target bacteria. This innovative approach allows for rapid initiation of treatment by physicians, leading to improved medical outcomes for patients. Through its advanced platform, Locus Biosciences seeks to address the challenges posed by pathogenic bacteria in a precise and targeted manner.

Baebies develops and manufactures innovative screening equipment for newborn babies. Its flagship product, SEEKER, is an FDA-authorized laboratory solution that simultaneously performs multiple assays using a single dried blood spot specimen. FINDER, another key product, enables near-patient testing in pediatric care. Baebies serves hospitals and public health labs worldwide.

Advanced Chemotherapy Technologies is a healthcare company that is developing breakthrough combination drug-device technologies for treating pancreatic cancer.

Baebies develops and manufactures innovative screening equipment for newborn babies. Its flagship product, SEEKER, is an FDA-authorized laboratory solution that simultaneously performs multiple assays using a single dried blood spot specimen. FINDER, another key product, enables near-patient testing in pediatric care. Baebies serves hospitals and public health labs worldwide.

Dignify Therapeutics is a drug development company based in Raleigh, North Carolina. Founded in 2013, it focuses on restoring voluntary control of bladder and bowel functions for patients with spinal cord injury, spina bifida, multiple sclerosis, and other neurological conditions through novel pharmaceutical agents.

OneFul Health is an e-pharmacy for personalized therapies, combining 3-7 prescription drugs into one small capsule or gel packet. Provide telemedicine physician network connections and home tests for biomarkers and genomic poly-scores to formulate combination treatments with reduced adverse side effects and improved adherence. Founded in 2013 as Panacea BioMatx Inc as a healthcare technology development company. It spun-off Panaceutics.com in 2021, then renamed to OneFul Health to commercialize D2C and B2B personlized pharmaceutical products. Owns accredited pharmacy facilities as its regulatory platform in nine states.

Jenken Biosciences is a specialty pharmaceutical company focused on the development and commercialization of innovative small molecules targeting TLR4 antagonism. TLR4 plays a crucial role in mediating inflammatory responses and has garnered significant clinical interest due to its association with various conditions, including chronic liver disease, inflammatory bowel disease, cancer, diabetes, and organ damage in the kidneys and lungs. The company's strategy emphasizes reducing time-to-market and development costs by repurposing approved drugs, while also advancing a robust pipeline of novel chemical entities aimed at treating chronic liver disease, inflammatory bowel disease, rheumatoid arthritis, and diabetes. Additionally, Jenken Biosciences utilizes proprietary technology for cytokine modulation to address fatty liver diseases and aims to restore kidney function, regardless of the underlying cause.